THE JOURNAL OF IMMUNOLOGY

Vol. XXVI FEBRUARY, 1934 No. 2

PUBLISHED MONTHLY BY THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS

ADVISORY BOARD SIMON FLEXNER ROBERT MUIR THEOBALD SMITH New York, N. Y. Glasgow, Scotland Princeton, N. J. LUDVIG HEKTOEN G. H. F. NUTTALL F. G. Novr Chicago,Ill. Cambridge, England Ann Arbor, Mich. KARL LANDSTEINER WILLIAM H. PARK WILLIAM H. WELCH New York, N. Y. New York, N. Y. Baltimore, Md. A. E. WRIGHT London, England

CONTENTS

AUGUSTUS WADSWORTH. The Action of Bacterial Toxins ...... 81 E. W. SCHULTZ AND L. P. GEBHARDT. Immune Serum Production in Poliomyelitis Refractory Animals ...... 93 E. W. SCHULTZ, C. E. CLIFTON, L. P. GEBHARDT AND J. V. CHAM- BERS. IS the Eberson Colloidal Gold Test Specific for Polio- myelitis Antibodies? ...... 119 NEWELL S. FERRY. Meningococeus Toxin and Antitoxin. III. Further Tests on Monkeys ...... 133 NEWELL S. FERRY AND PHILIP J. SCHORNACK. Meningococcus Toxin and Antitoxin. IV. Further Tests on Guinea Pigs and Rabbits ...... 143

wl tootl M THE WILLIAMS & WILKINS COMPANY BALTIMORE, U. S. A. Made in United States of America THE JOURNAL OF IMMUNOLOGY

EDITED BY ARTHUR F. COCA AND JOHN C. TORREY

BOARD OF EDITORS J. F. ANDERSON DENNIS EMBLETON W. H. MANWARING New Brunswick, N. J° London, England Leland Stanford Jr. Univ. JOHN AUER St; Louis L.W. FAMULENER Jo MC][NTOSH A. BREINL St. Luke's Hoepital, N. Y. London, England Townsville, Queensland, J.G. FITZGERALD C. J. MARTIN Australia University of Toronto London, England J, BRONFENBRENNER St. Louis WILLIAM W. FORD M. J. ROSENAU Harvard University C. H. B~OWNING Johns Hopkins University Glasgow, Scotland F. P. GAY J. HENDERSON SMITH WILLIAM BULLOCH Coil. of Phys. & Surg., N. Y. London, England London, England J. W. JOBLING R. P. STRONG RuFus I. COLE Harvard Univers|ty Rockefeller Institute Coll. of Phys. & Surg., N. Y, H. R. DEAN JOHN A. KOLMER F. H. T~.ALE University of Cambridge, University of Pennsylvania London, England Cambridge, England GEORGES DREYER PRESTON KYES H, G° WELLS Oxford, England University of Chicago University of Chicago WILLIAM J. ELSER J. C. G. LEDINGHAM HANS ZINSSER Cornel] University London, England Harvard University

THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS OFFICERS AND COUNCIL PAST PRESIDENTS Dr. Thomas M. Rivers, Presiden$ Rockefeller Institute, Dr. James W. Jobling 66th Street and York Avenue, Dr. John A. Kolmer New York City Dr. William H. Park Dr. Arthur F. Coca, See'y-Treas. Dr. G. W. McCoy Pearl River Dr. Rufus I. Cole New York Dr. Hans Zinsser Dr. Richard Weft Dr. A. B. Wadsworth Dr. Frederick P. Gay Dr. A. R. Dochez Dr. F. G. Novy Dr. Arthur F. Coca Dr. H. Gideon Wells Dr. Stanhope Bayne-Jones Dr. W.H. Manwaring Dr. Oswald T. Avery Dr. Ludvig Hektoen Dr. Eugene L. Opie Dr. Karl Landsteiner

Entered a~ second-class matter February 21, I916, at the Post Office at Baltimore, Maryland, under the ~t of March 3, 1879. Copyright, 1934, by The Williams & Wilkins Comnsny