M.Sc Ist Yr MICROBIOLOGY a Bottle of Wine Contains More Philosophy Than All the Books in the World
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Bedford Stem Cell Research Foundation
bedford stem cell research foundation ||| The Potential for Miracles ||| Recent advances in stem cell research have raised the hope Founded in 1996, the Bedford Stem Cell of curing diseases once believed to be incurable: heart failure, spinal cord injury, diabetes, Alzheimer’s, Parkinson’s, Research Foundation is a biomedical AIDS. These diseases are the result of the death of specifi c types of cells, such as nerves and the cells in the pancreas institute that exists to conduct stem that produce insulin. For reasons that are not understood, cell and related research for diseases new cells do not automatically replace defective cells in some tissues such as spinal cord, brain and pancreas. and conditions that currently have no Other tissues, such as skin and blood, routinely replace effective methods of treatment or cure. dying cells with new cells recruited from reserve supplies that maintain the potential to become active and multiply when needed. [fi g 1] Such cells are called stem cells. Skin stem cells are examples of adult stem cells, so-called ||| The Foundation ||| because they can become only one type of tissue, e.g. skin. In contrast, cells from early embryos are pluripotent, that Bedford Stem Cell Research Foundation is at the forefront is, they have the potential to become all types of tissues. of stem cell and related research. Founded in 1996, the Experiments with laboratory mice have demonstrated that Foundation has an established community of scientists pluripotent stem cells can replace dead cells in all organs investigating stem cell therapies. Committed to conduct- including the heart, which does not have its own supply of ing ethical research, the Foundation relies on its Ethics stem cells. -
And the Winner Should Be
EDITORIAL And the winner should be… It is time that the tremendous contribution made by Carl Woese to microbiology, medicine and biology as a whole is rewarded by the Nobel committee. Among microbiologists, Carl Woese’s achievements are isolates can allow rapid disease diagnosis. As culturing is well known. His most lauded accomplishments include the not required, sequence analysis can be used to diagnose recognition of an entirely new domain of organisms, many different infectious diseases and is now common in the Archaea1, and the subsequent introduction of the clinical diagnostic laboratories. In the case of Whipple’s three-domain phylogeny2 that is now widely recognized as disease, it even led to the identification of a previously the most accurate reflection of the relatedness of all organ- unknown bacterium (Tropheryma whipplei) as the cause4. isms. We are so used to using neatly organized taxonomic Second, using 16S rRNA-based phylogeny, it is possible to trees to demonstrate the relationships between different study the human microbiota at a detailed level. In recent microorganisms that it is easy to forget that not so long ago years, we have begun to obtain a comprehensive picture the classification of bacteria was considered hopeless. In of the composition of the human-associated microbiota 1963 Roger Stanier, then one of the foremost researchers in various niches, including the gut, skin and oral cavity. in the field of bacterial classification, proclaimed that “The This has led to the insight that shifts in the gut-associated ultimate scientific goal of biological classification cannot microbiota are associated with diseases such as Crohn’s be achieved in the case of bacteria” (REF. -
Cambridge's 92 Nobel Prize Winners Part 2 - 1951 to 1974: from Crick and Watson to Dorothy Hodgkin
Cambridge's 92 Nobel Prize winners part 2 - 1951 to 1974: from Crick and Watson to Dorothy Hodgkin By Cambridge News | Posted: January 18, 2016 By Adam Care The News has been rounding up all of Cambridge's 92 Nobel Laureates, celebrating over 100 years of scientific and social innovation. ADVERTISING In this installment we move from 1951 to 1974, a period which saw a host of dramatic breakthroughs, in biology, atomic science, the discovery of pulsars and theories of global trade. It's also a period which saw The Eagle pub come to national prominence and the appearance of the first female name in Cambridge University's long Nobel history. The Gender Pay Gap Sale! Shop Online to get 13.9% off From 8 - 11 March, get 13.9% off 1,000s of items, it highlights the pay gap between men & women in the UK. Shop the Gender Pay Gap Sale – now. Promoted by Oxfam 1. 1951 Ernest Walton, Trinity College: Nobel Prize in Physics, for using accelerated particles to study atomic nuclei 2. 1951 John Cockcroft, St John's / Churchill Colleges: Nobel Prize in Physics, for using accelerated particles to study atomic nuclei Walton and Cockcroft shared the 1951 physics prize after they famously 'split the atom' in Cambridge 1932, ushering in the nuclear age with their particle accelerator, the Cockcroft-Walton generator. In later years Walton returned to his native Ireland, as a fellow of Trinity College Dublin, while in 1951 Cockcroft became the first master of Churchill College, where he died 16 years later. 3. 1952 Archer Martin, Peterhouse: Nobel Prize in Chemistry, for developing partition chromatography 4. -
PRESS RELEASE National Academies and the Law Collaborate
The Royal Society of Edinburgh, Scotland's National Academy, is Scottish Charity No. SC000470 PRESS RELEASE For Immediate Release: 11 April 2016 National academies and the law collaborate to provide better understanding of science to the courts The Lord Chief Justice, The Royal Society and Royal Society of Edinburgh today (11 April 2016) announce the launch of a project to develop a series of guides or ‘primers’ on scientific topics which is designed to assist the judiciary, legal teams and juries when handling scientific evidence in the courtroom. The first primer document to be developed will cover DNA analysis. The purpose of the primer documents is to present, in plain English, an easily understood and accurate position on the scientific topic in question. The primers will also cover the limitations of the science, challenges associated with its application and an explanation of how the scientific area is used within the judicial system. An editorial board, drawn from the judicial and scientific communities, will develop each individual primer. Before publication, the primers will be peer reviewed by practitioners, including forensic scientists and the judiciary, as well as the public. Lord Thomas, Lord Chief Justice for England and Wales says, “The launch of this project is the realisation of an idea the judiciary has been seeking to achieve. The involvement of the Royal Society and Royal Society of Edinburgh will ensure scientific rigour and I look forward to watching primers develop under the stewardship of leading experts in the fields of law and science.” Dr Julie Maxton, Executive Director of the Royal Society, says, “This project had its beginnings in our 2011 Brain Waves report on Neuroscience and the Law, which highlighted the lack of a forum in the UK for scientists, lawyers and judges to explore areas of mutual interest. -
Before the Scientific and Medical Accountability
BEFORE THE SCIENTIFIC AND MEDICAL ACCOUNTABILITY STANDARDS WORKING GROUP OF THE INDEPENDENT CITIZENS' OVERSIGHT COMMITTEE TO THE CALIFORNIA INSTITUTE FOR REGENERATIVE MEDICINE ORGANIZED PURSUANT TO THE CALIFORNIA STEM CELL RESEARCH AND CURES ACT REGULAR MEETING LOCATION: AS INDICATED ON THE AGENDA DATE: JULY 24, 2013 10 A.M. REPORTER: BETH C. DRAIN, CSR CSR. NO. 7152 BRS FILE NO.: 94597 BARRISTERS' REPORTING SERVICE I N D E X ITEM DESCRIPTION PAGE NO. CALL TO ORDER 3 ROLL CALL 3 CONSIDERATION OF IMTERIM REGULATION REGARDING USE OF STEM CELL LINES PUBLIC COMMENT 2 160 S. OLD SPRINGS ROAD, SUITE 270, ANAHEIM, CALIFORNIA 92808 1-800-622-6092 1-714-444-4100 EMAIL: [email protected] BARRISTERS' REPORTING SERVICE 1 SAN FRANCISCO, CALIFORNIA; JULY 24, 2013 2 12 P.M. 3 4 DR. LOMAX: WHY DON'T WE START WITH ROLL. 5 IT'S ONLY ONE PERSON WHO'S RESPONDED THAT I KNOW IS 6 NOT HERE ON-SITE, BUT HOPEFULLY TED PETERS WILL BE 7 ARRIVING SHORTLY. 8 SHERRY LANSING. 9 MS. LANSING: HERE. 10 DR. LOMAX: BERNARD LO. 11 CHAIRMAN LO: HERE. 12 DR. LOMAX: JEFF BODKIN. 13 DR. BODKIN: HERE. 14 DR. LOMAX: MARCY FEIT. TIM KAMP. 15 DR. KAMP: YES. 16 DR. LOMAX: ANN KIESSLING. KEN OLDEN. 17 FRANCISCO PRIETO. 18 DR. PRIETO: HERE. 19 DR. LOMAX: TED PETERS. 20 DR. PETERS: TED PETERS IS HERE, YES, ON 21 THE PHONE. 22 DR. LOMAX: OH, TERRIFIC. DOROTHY 23 ROBERTS. 24 DR. ROBERTS: YES. I'M HERE ON THE PHONE. 25 DR. LOMAX: TERRIFIC. 3 160 S. OLD SPRINGS ROAD, SUITE 270, ANAHEIM, CALIFORNIA 92808 1-800-622-6092 1-714-444-4100 EMAIL: [email protected] BARRISTERS' REPORTING SERVICE 1 JEFF SHEEHY. -
Jeffreys Alec
Alec Jeffreys Personal Details Name Alec Jeffreys Dates 09/01/1950 Place of Birth UK (Oxford) Main work places Leicester Principal field of work Human Molecular Genetics Short biography To follow Interview Recorded interview made Yes Interviewer Peter Harper Date of Interview 16/02/2010 Edited transcript available See below Personal Scientific Records Significant Record sets exists Records catalogued Permanent place of archive Summary of archive Interview with Professor Alec Jeffreys, Tuesday 16 th February, 2010 PSH. It’s Tuesday 16 th February, 2010 and I am talking with Professor Alec Jeffreys at the Genetics Department in Leicester. Alec, can I start at the beginning and ask when you were born and where? AJ. I was born on the 9 th January 1950, in Oxford, in the Radcliffe Infirmary and spent the first six years of my life in a council house in Headington estate in Oxford. PSH. Were you schooled in Oxford then? AJ. Up until infant’s school and then my father, who worked at the time in the car industry, he got a job at Vauxhall’s in Luton so then we moved off to Luton. So that was my true formative years, from 6 to 18, spent in Luton. PSH. Can I ask in terms of your family and your parents in particular, was there anything in the way of a scientific background, had either of them or any other people in the family been to university before. Or were you the first? AJ. I was the first to University, so we had no tradition whatsoever of going to University. -
Science in Court
www.nature.com/nature Vol 464 | Issue no. 7287 | 18 March 2010 Science in court Academics are too often at loggerheads with forensic scientists. A new framework for certification, accreditation and research could help to heal the breach. o the millions of people who watch television dramas such as face more legal challenges to their results as the academic critiques CSI: Crime Scene Investigation, forensic science is an unerring mount. And judges will increasingly find themselves refereeing Tguide to ferreting out the guilty and exonerating the inno- arguments over arcane new technologies and trying to rule on the cent. It is a robust, high-tech methodology that has all the preci- admissibility of the evidence they produce — a struggle that can sion, rigour and, yes, glamour of science at its best. lead to a body of inconsistent and sometimes ill-advised case law, The reality is rather different. Forensics has developed largely which muddies the picture further. in isolation from academic science, and has been shaped more A welcome approach to mend- by the practical needs of the criminal-justice system than by the ing this rift between communities is “National leadership canons of peer-reviewed research. This difference in perspective offered in a report last year from the is particularly has sometimes led to misunderstanding and even rancour. For US National Academy of Sciences important example, many academics look at techniques such as fingerprint (see go.nature.com/WkDBmY). Its given the highly analysis or hair- and fibre-matching and see a disturbing degree central recommendation is that the interdisciplinary of methodological sloppiness. -
Watson's Way with Words
books and arts My teeth were set on edge by reference to “the stable form of uranium”,a violation of Kepler’s second law in a description of how the Earth’s orbit would change under various circumstances, and by “the rest mass of the neutrino is 4 eV”. Collins has been well served by his editor and publisher, but not perfectly. There are un-sort-out-able mismatches between text and index, references and figures; acronyms D.WRITING LIFE OF JAMES THE WATSON in the second half of the alphabet go un- decoded; several well-known names are misspelled. And readers are informed that Weber’s death occurred “on September 31, E. C. FRIEDBERG, 2000”. Well, Joe always said he could do things that other people couldn’t, but there are limits. Incidentally, my adviser was partly right: I should not have agreed to review this book. It is very much harder to hear harsh, some- times false, things said about one’s spouse after he can no longer defend himself. I am not alone in this feeling. Carvel Gold, widow of Thomas Gold, whose work was also far from universally accepted (see Nature 430, 415;2004),says the same thing. ■ Virginia Trimble is at the University of California, Irvine, California 92697-4575, USA. She and Joe The write idea? In The Double Helix,James Watson gave Weber were married from 16 March 1972 until his a personal account of the quest for the structure of DNA. death on 30 September 2000. Watson set out to produce a good story that the public would enjoy as much as The Great Gatsby.He started writing in 1962 with the working title “Honest Jim”,which is illumi- Watson’s way nating in itself. -
René Dubos, Tuberculosis, and the “Ecological Facets of Virulence”
HPLS (2017) 39:15 DOI 10.1007/s40656-017-0142-5 ORIGINAL PAPER René Dubos, tuberculosis, and the “ecological facets of virulence” Mark Honigsbaum1 Received: 15 January 2017 / Accepted: 23 June 2017 / Published online: 4 July 2017 © The Author(s) 2017. This article is an open access publication Abstract Reflecting on his scientific career toward the end of his life, the French- educated medical researcher Rene´ Dubos presented his flowering as an ecological thinker as a story of linear progression—the inevitable product of the intellectual seeds planted in his youth. But how much store should we set by Dubos’s account of his ecological journey? Resisting retrospective biographical readings, this paper seeks to relate the development of Dubos’s ecological ideas to his experimental practices and his career as a laboratory researcher. In particular, I focus on Dubos’s studies of tuberculosis at the Rockefeller Institute in the period 1944–1956—studies which began with an inquiry into the tubercle bacillus and the physiochemical determinants of virulence, but which soon encompassed a wider investigation of the influence of environmental forces and host–parasite interactions on susceptibility and resistance to infection in animal models. At the same time, through a close reading of Dubos’s scientific papers and correspondence, I show how he both drew on and distinguished his ecological ideas from those of other medical researchers such as Theobald Smith, Frank Macfarlane Burnet, and Frank Fenner. However, whereas Burnet and Fenner tended to view ecological interactions at the level of populations, Dubos focused on the interface of hosts and parasites in the physio- logical environments of individuals. -
Milestones and Personalities in Science and Technology
History of Science Stories and anecdotes about famous – and not-so-famous – milestones and personalities in science and technology BUILDING BETTER SCIENCE AGILENT AND YOU For teaching purpose only December 19, 2016 © Agilent Technologies, Inc. 2016 1 Agilent Technologies is committed to the educational community and is willing to provide access to company-owned material contained herein. This slide set is created by Agilent Technologies. The usage of the slides is limited to teaching purpose only. These materials and the information contained herein are accepted “as is” and Agilent makes no representations or warranties of any kind with respect to the materials and disclaims any responsibility for them as may be used or reproduced by you. Agilent will not be liable for any damages resulting from or in connection with your use, copying or disclosure of the materials contained herein. You agree to indemnify and hold Agilent harmless for any claims incurred by Agilent as a result of your use or reproduction of these materials. In case pictures, sketches or drawings should be used for any other purpose please contact Agilent Technologies a priori. For teaching purpose only December 19, 2016 © Agilent Technologies, Inc. 2016 2 Table of Contents The Father of Modern Chemistry The Man Who Discovered Vitamin C Tags: Antoine-Laurent de Lavoisier, chemical nomenclature Tags: Albert Szent-Györgyi, L-ascorbic acid He Discovered an Entire Area of the Periodic Table The Discovery of Insulin Tags: Sir William Ramsay, noble gas Tags: Frederick Banting, -
Microbiology Immunology Cent
years This booklet was created by Ashley T. Haase, MD, Regents Professor and Head of the Department of Microbiology and Immunology, with invaluable input from current and former faculty, students, and staff. Acknowledgements to Colleen O’Neill, Department Administrator, for editorial and research assistance; the ASM Center for the History of Microbiology and Erik Moore, University Archivist, for historical documents and photos; and Ryan Kueser and the Medical School Office of Communications & Marketing, for design and production assistance. UMN Microbiology & Immunology 2019 Centennial Introduction CELEBRATING A CENTURY OF MICROBIOLOGY & IMMUNOLOGY This brief history captures the last half century from the last history and features foundational ideas and individuals who played prominent roles through their scientific contributions and leadership in microbiology and immunology at the University of Minnesota since the founding of the University in 1851. 1. UMN Microbiology & Immunology 2019 Centennial Microbiology at Minnesota MICROBIOLOGY AT MINNESOTA Microbiology at Minnesota has been From the beginning, faculty have studied distinguished from the beginning by the bacteria, viruses, and fungi relevant to breadth of the microorganisms studied important infectious diseases, from and by the disciplines and sub-disciplines early studies of diphtheria and rabies, represented in the research and teaching of through poliomyelitis, streptococcal and the faculty. The Microbiology Department staphylococcal infection to the present itself, as an integral part of the Medical day, HIV/AIDS and co-morbidities, TB and School since the department’s inception cryptococcal infections, and influenza. in 1918-1919, has been distinguished Beyond medical microbiology, veterinary too by its breadth, serving historically microbiology, microbial physiology, as the organizational center for all industrial microbiology, environmental microbiological teaching and research microbiology and ecology, microbial for the whole University. -
Infectious Disease in Philadelphia, 1690- 1807
ABSTRACT Title of Dissertation: INFECTIOUS DISEASE IN PHILADELPHIA, 1690- 1807: AN ECOLOGICAL PERSPECTIVE Gilda Marie Anroman, Doctor of Philosophy, 2006 Dissertation directed by: Professor Mary Corbin Sies Department of American Studies This dissertation examines the multiple factors that influenced the pattern and distribution of infectious disease in Philadelphia between the years 1690 and 1807, and explores the possible reasons for the astonishingly high level of death from disease throughout the city at this time . What emerges from this study is a complex picture of a city undergoing rapid cultural and epidemiological changes . Large -scale immigration supplied a susceptible population group, as international trade, densely packed street s, unsanitary living conditions, and a stagnant and contaminated water supply combined to create ideal circumstances for the proliferation of both pathogen s and vectors, set ting the stage for the many public health crises that plagued Philadelphia for more than one hundred years. This study uses an ecological perspective to understand how disease worked in Philadelphia . The idea that disease is virtually always a result of the interplay of the environment, the genetic and physical make -up of the individual , and the agent of disease is one of the most importan t cause and effect ideas underpinned by epidemiology. This dissertation integrates me thods from the health sciences, humanities, and social sciences to demonstrate how disease “emergence” in Philadelphia was a dynamic feature of the interrelationships between people and their socio -cultural and physical environments. Classic epidemiological theory , informed by ecological thinking, is used to rev isit the city’s reconstructed demographic data, bills of mortality, selected diaries (notably that of Elizabeth Drinker ), personal letters, contemporary observations and medical literature .