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CNS , Cerebral Spinal Fluid and Supply Contents:

❑Meninges

❑CSF and Ventricles

❑Blood supply of the MENINGES • The meninges functions to support, protect and nourishe CNS tissue. • the production of helps by acting as a shock absorber, by circulating nutrients, and by getting rid of waste products • three layers: , and . • Between these two layers are DURA meter the . • the outermost layer of the • drain blood from the brain to the meninges, It is thick, tough and internal jugular , where it is inextensible. returned to the heart. • has two sheets: Periosteal layer – lines the inner surface of the cranium. Meningeal layer – deep to the periosteal layer inside the cranial cavity. It is the only layer present in the . structure purpose the largest, sickle-shaped; separates the cerebral hemispheres. Starts from the frontal crest of and the running to the internal occipital protuberance. Inervated: ophthalmic division of Falx cerebri trigeminal (V1) Tentorium Tentorium the second largest, crescent-shaped; cerebelli cerebelli separates the occipital Falx lobes from . The falx cerebri cerebelli attaches to it giving a tentlike appearance. Diaphragm Inervation: V1 a sellae vertical infolding; lies inferior to the tentorium cerebelli, separating the cerebellar hemispheres.

Diaphragma smallest infolding; covers the pituitary sellae gland and . Clinical correlation Extradural and Subdural Haematomas • A haematoma is a collection of blood. Which cause a rapid increase in intra- cranial pressure • The dura mater receives its own vasculature; primarily from the middle meningeal and . • Extradural – arterial blood collects between the and periosteal layer of the dura. The causative vessel is usually the , a consequence of brain trauma. • Subdural – venous blood collects between the dura and the arachnoid mater. It results from damage to cerebral veins as they empty into the dural venous sinuses. Arachnoid space • The arachnoid mater is the middle layer of the meninges • is avascular, and does not receive any innervation. • Underneath the arachnoid is a space known as the sub-arachnoid space • Small projections of arachnoid mater into the dura (known as arachnoid granulations) allow CSF to re-enter the circulation via the dural venous sinuses. Pia mater • underneath the sub-arachnoid • : a network space. It is very thin, and tightly of and adhered to the surface of the (specialized ciliated epithelial brain and . tissue) that produce • follow the contours of the brain: cerebrospinal fluid. the gyri and fissures. • outer layer consisting of collagen • highly vascularized fibers and an inner layer that encases the entire spinal cord. Meningeal layers and levels in the spinal cord

Contents:

✓Meninges

❑CSF and Ventricles

❑Blood supply of the brain The Ventricles NAME FROM TO interventricular foramina (Monro) lateral ventricles (Sylvius) third ventricle median subarachnoid aperture (Magendie) space via fourth ventricle the right and left lateral aperture (Luschka) subarachnoid space via fourth ventricle the cistern of great cerebral vein CSF and the Ventricles

• The ventricles are filled with cerebrospinal fluid (CSF) which cushions the brain and spinal cord • CSF is produced by modified ependymal cells of the choroid plexus found in all components of the EXCEPT for the cerebral aqueduct and the posterior and anterior horns of the . • fluid then flows around the to be reabsorbed via the arachnoid granulations into the venous sinuses, where it passes through the and major venous system.

Clinical correlations

As cerebrospinal fluid is continually produced by the choroid plexus within the ventricles, a blockage of outflow leads to increasingly high pressure in the lateral ventricles. Which can commonly lead to . Contents:

✓Meninges

✓CSF and Ventricles

❑Blood supply of the brain Blood supply

Circle of willis Basilary a. Formed by the: Branches of the Basilar Artery: 1. Internal carotid 1. Pontine 2. Anterior cerebral 2. Labyrinthine 3. Anterior communicating 3. Anterior-Inferior Cerebellar 4. Posterior cerebral 4. Superior Cerebellar 5. Posterior communicating 5. Posterior Cerebral “PLAISP” Remember NOT the middle cerebral

An easy to follow guide for the blood supply https://www.youtube.com/watch?v=uMMMqkVZAhk

The anterior cerebral artery

• extends upward and forward from the . It supplies the frontal lobes • logical thought, • personality, • voluntary movement of the legs. • in the anterior cerebral artery results in opposite leg weakness The middle cerebral artery • is the largest branch of the internal carotid. • supplies a portion of the frontal lobe and the lateral surface of the temporal and parietal lobes • the primary motor and sensory areas of: • the face • throat • hand and arm • the dominant hemisphere, the areas for speech. The posterior cerebral

• from the basilar artery. • supply the temporal and occipital lobes

• Clinical symptoms associated with occlusion depend on the location of the occlusion. may include: thalamic syndrome, thalamic perforate syndrome, Weber’s syndrome, contralateral hemplegia, hemianopsia and a variety of other symptoms, including including color blindness, failure to see to-and-fro movements, verbal dyslexia, and hallucinations. Ant. Cerebral a.

Ant. Communicating a. Opthalmic a.

Internal carotid a. Middle cerebral a. with branch of Ant. Chorodial a. Post. Communicating a.

Post. Cerebral a.

Sup. Cerebellar a. Basillary a. with pontine branches Labyrinthine a. Ant. Inf. Cerebellar a. Post. Inf. Cerebellar a. with branches of Post. Spinal a. Vertebral a. Ant. Spinal a.