Spinal Cord, Spinal Nerves, and the Autonomic Nervous System
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NS201C Anatomy 1: Sensory and Motor Systems
NS201C Anatomy 1: Sensory and Motor Systems 25th January 2017 Peter Ohara Department of Anatomy [email protected] The Subdivisions and Components of the Central Nervous System Axes and Anatomical Planes of Sections of the Human and Rat Brain Development of the neural tube 1 Dorsal and ventral cell groups Dermatomes and myotomes Neural crest derivatives: 1 Neural crest derivatives: 2 Development of the neural tube 2 Timing of development of the neural tube and its derivatives Timing of development of the neural tube and its derivatives Gestational Crown-rump Structure(s) age (Weeks) length (mm) 3 3 cerebral vesicles 4 4 Optic cup, otic placode (future internal ear) 5 6 cerebral vesicles, cranial nerve nuclei 6 12 Cranial and cervical flexures, rhombic lips (future cerebellum) 7 17 Thalamus, hypothalamus, internal capsule, basal ganglia Hippocampus, fornix, olfactory bulb, longitudinal fissure that 8 30 separates the hemispheres 10 53 First callosal fibers cross the midline, early cerebellum 12 80 Major expansion of the cerebral cortex 16 134 Olfactory connections established 20 185 Gyral and sulcul patterns of the cerebral cortex established Clinical case A 68 year old woman with hypertension and diabetes develops abrupt onset numbness and tingling on the right half of the face and head and the entire right hemitrunk, right arm and right leg. She does not experience any weakness or incoordination. Physical Examination: Vitals: T 37.0° C; BP 168/87; P 86; RR 16 Cardiovascular, pulmonary, and abdominal exam are within normal limits. Neurological Examination: Mental Status: Alert and oriented x 3, 3/3 recall in 3 minutes, language fluent. -
Distance Learning Program Anatomy of the Human Brain/Sheep Brain Dissection
Distance Learning Program Anatomy of the Human Brain/Sheep Brain Dissection This guide is for middle and high school students participating in AIMS Anatomy of the Human Brain and Sheep Brain Dissections. Programs will be presented by an AIMS Anatomy Specialist. In this activity students will become more familiar with the anatomical structures of the human brain by observing, studying, and examining human specimens. The primary focus is on the anatomy, function, and pathology. Those students participating in Sheep Brain Dissections will have the opportunity to dissect and compare anatomical structures. At the end of this document, you will find anatomical diagrams, vocabulary review, and pre/post tests for your students. The following topics will be covered: 1. The neurons and supporting cells of the nervous system 2. Organization of the nervous system (the central and peripheral nervous systems) 4. Protective coverings of the brain 5. Brain Anatomy, including cerebral hemispheres, cerebellum and brain stem 6. Spinal Cord Anatomy 7. Cranial and spinal nerves Objectives: The student will be able to: 1. Define the selected terms associated with the human brain and spinal cord; 2. Identify the protective structures of the brain; 3. Identify the four lobes of the brain; 4. Explain the correlation between brain surface area, structure and brain function. 5. Discuss common neurological disorders and treatments. 6. Describe the effects of drug and alcohol on the brain. 7. Correctly label a diagram of the human brain National Science Education -
Split Spinal Cord Malformations in Children
Split spinal cord malformations in children Yusuf Ersahin, M.D., Saffet Mutluer, M.D., Sevgül Kocaman, R.N., and Eren Demirtas, M.D. Division of Pediatric Neurosurgery, Department of Neurosurgery, and Department of Pathology, Ege University Faculty of Medicine, Izmir, Turkey The authors reviewed and analyzed information on 74 patients with split spinal cord malformations (SSCMs) treated between January 1, 1980 and December 31, 1996 at their institution with the aim of defining and classifying the malformations according to the method of Pang, et al. Computerized tomography myelography was superior to other radiological tools in defining the type of SSCM. There were 46 girls (62%) and 28 boys (38%) ranging in age from less than 1 day to 12 years (mean 33.08 months). The mean age (43.2 months) of the patients who exhibited neurological deficits and orthopedic deformities was significantly older than those (8.2 months) without deficits (p = 0.003). Fifty-two patients had a single Type I and 18 patients a single Type II SSCM; four patients had composite SSCMs. Sixty-two patients had at least one associated spinal lesion that could lead to spinal cord tethering. After surgery, the majority of the patients remained stable and clinical improvement was observed in 18 patients. The classification of SSCMs proposed by Pang, et al., will eliminate the current chaos in terminology. In all SSCMs, either a rigid or a fibrous septum was found to transfix the spinal cord. There was at least one unrelated lesion that caused tethering of the spinal cord in 85% of the patients. -
Clinical Presentations of Lumbar Disc Degeneration and Lumbosacral Nerve Lesions
Hindawi International Journal of Rheumatology Volume 2020, Article ID 2919625, 13 pages https://doi.org/10.1155/2020/2919625 Review Article Clinical Presentations of Lumbar Disc Degeneration and Lumbosacral Nerve Lesions Worku Abie Liyew Biomedical Science Department, School of Medicine, Debre Markos University, Debre Markos, Ethiopia Correspondence should be addressed to Worku Abie Liyew; [email protected] Received 25 April 2020; Revised 26 June 2020; Accepted 13 July 2020; Published 29 August 2020 Academic Editor: Bruce M. Rothschild Copyright © 2020 Worku Abie Liyew. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Lumbar disc degeneration is defined as the wear and tear of lumbar intervertebral disc, and it is mainly occurring at L3-L4 and L4-S1 vertebrae. Lumbar disc degeneration may lead to disc bulging, osteophytes, loss of disc space, and compression and irritation of the adjacent nerve root. Clinical presentations associated with lumbar disc degeneration and lumbosacral nerve lesion are discogenic pain, radical pain, muscular weakness, and cutaneous. Discogenic pain is usually felt in the lumbar region, or sometimes, it may feel in the buttocks, down to the upper thighs, and it is typically presented with sudden forced flexion and/or rotational moment. Radical pain, muscular weakness, and sensory defects associated with lumbosacral nerve lesions are distributed on -
Bone Grafts and Implants in Spine Surgery
CHAPTER 39 BONE GRAFTS AND IMPLANTS IN SPINE SURGERY Ken Hsu James F. Zucherman Arthur H. White Recent advances in both fusion tech of scaffolds, bridges, spacers, fillers of J • niques and instrumentation have defects, and replacements of bone lost. markedly facilitated the treatment of Immobilization of multiple motion seg spinaldisorders. Yet asignificantnumber ments is frequently necessary in the spine; of patients exist who continue to have great demands arc made on bone grafts. pseudarthroses. Despite the surgical ad In the lumbosacral spine, body weight vances the essentials ofa successful spinal and muscular forcesimpart loads equal to fusion still appear to be the effective ap three or four times body weight. It is plication of sound bone grafting princi not surprising that the highest rate of ples. These principles, along with the bone graft failure is seen in the lumbo techniques, problems, and complications sacral spine. Hence, the following is a associated with bone grafting, arc re discussion of technical problems, bio- viewed in this chapter. mechanical and physiologic character The loss ofbone in the spine often pre istics of bone grafts, and implants. sents serious difficulties not seen in other areas. The most favorable replacement THE AUTOGRAFT would still be a bone graft that fills the Autograft, or bone graft transplanted defect and becomes incorporated into the from one site to another in the same indi spine. However, the availability of ap vidual, is considered to be the most bio propriate bone to replace the loss is a logically suitable. Its advantages include: significant problem. Alternatives to bone 1. -
What to Expect After Having a Subarachnoid Hemorrhage (SAH) Information for Patients and Families Table of Contents
What to expect after having a subarachnoid hemorrhage (SAH) Information for patients and families Table of contents What is a subarachnoid hemorrhage (SAH)? .......................................... 3 What are the signs that I may have had an SAH? .................................. 4 How did I get this aneurysm? ..................................................................... 4 Why do aneurysms need to be treated?.................................................... 4 What is an angiogram? .................................................................................. 5 How are aneurysms repaired? ..................................................................... 6 What are common complications after having an SAH? ..................... 8 What is vasospasm? ...................................................................................... 8 What is hydrocephalus? ............................................................................... 10 What is hyponatremia? ................................................................................ 12 What happens as I begin to get better? .................................................... 13 What can I expect after I leave the hospital? .......................................... 13 How will the SAH change my health? ........................................................ 14 Will the SAH cause any long-term effects? ............................................. 14 How will my emotions be affected? .......................................................... 15 When should -
A Cellular Atlas of the Developing Meninges Reveals Meningeal Fibroblast Diversity and Function
bioRxiv preprint doi: https://doi.org/10.1101/648642; this version posted May 24, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. 1 2 3 4 Title: A cellular atlas of the developing meninges reveals meningeal fibroblast diversity and function 5 6 Authors: John DeSisto1,2,3,, Rebecca O’Rourke2, Stephanie Bonney1,3, Hannah E. Jones1,3, Fabien 7 Guimiot4, Kenneth L. Jones2 and Julie A. Siegenthaler1,3,5 8 9 1Department of Pediatrics Section of Developmental Biology, 2Department of Pediatrics Section of 10 Section of Hematology, Oncology, Bone Marrow Transplant, 3Cell Biology, Stem Cells and Development 11 Graduate Program, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045 USA, 12 4INSERM UMR 1141, Hôpital Robert Debré, 75019 Paris, France. 13 14 5Corresponding Author: 15 Julie A. Siegenthaler, PhD 16 University of Colorado, School of Medicine 17 Department of Pediatrics 18 12800 East 19th Ave MS-8313 19 Aurora, CO 80045 USA 20 Telephone #: 303-724-3123 21 E-mail: [email protected] 22 23 Key words (3-6 words): brain development, meninges, pial basement membrane, retinoic acid, human 24 meninges bioRxiv preprint doi: https://doi.org/10.1101/648642; this version posted May 24, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. 25 Abstract 26 The meninges, a multilayered structure that encases the CNS, is composed mostly of fibroblasts, 27 along with vascular and immune cells. -
The Blood Supply of the Lumbar and Sacral Plexuses in the Human Foetus* by M
J. Anat., Lond. (1964), 98, 1, 105-116 105 With 4 plates and 3 text-figures Printed in Great Britain The blood supply of the lumbar and sacral plexuses in the human foetus* BY M. H. DAYt Department of Anatomy, Royal Free Hospital School of Medicine INTRODUCTION The existence of a blood supply to peripheral nerve is well established. Recently, a number of authors have reviewed the literature of the field, among them Blunt (1956) and Abdullah (1958), who from their own observations have confirmed that peripheral nerves are supplied by regional vessels reinforcing longitudinally arranged channels which freely anastomose with each other. There is also evidence that posterior root ganglia are particularly well supplied with blood vessels (Abdullah, 1958), but the precise distribution and arrangement of arteries to some individual nerve trunks and plexuses is still in need of investigation. The literature reveals few references to the blood supply of the lumbar and sacral plexuses. The distribution of arteries to the roots and ganglia of the sacral nerves was noted by Haller (1756), but the most important contributions in this field were those of Bartholdy (1897) and Tonkoff (1898), whose observations on the lumbar and sacral plexuses form part of a general survey of the blood supply of peripheral nerve in man. They cited the lumbar, ilio-lumbar, median and lateral sacral arteries as well as the gluteal and pudendal vessels as sources of supply, but gave no indication of the frequency of these contributions. Subsequent authors including Hovelacque (1927), dealt briefly with the distribution of the lateral sacral, median sacral, gluteal and pudendal arteries to the sacral plexus, but treated more fully the blood supply of the sciatic nerve. -
Meninges,Cerebrospinal Fluid, and the Spinal Cord
The Nervous System SPINAL CORD Spinal Cord Continuation of CNS inferior to foramen magnum (medulla) Simpler Conducts impulses to and from brain Two way conduction pathway Reflex actions Spinal Cord Passes through vertebral canal Foramen magnum L2 Conus medullaris Filum terminale Cauda equina Cervical Cervical spinal nerves enlargement Dura and arachnoid Thoracic mater spinal nerves Lumbar enlargement Conus medullaris Lumbar Cauda spinal nerves equina Filum (a) The spinal cord and its nerve terminale Sacral roots, with the bony vertebral spinal nerves arches removed. The dura mater and arachnoid mater are cut open and reflected laterally. Figure 12.29a Spinal Cord Spinal nerves 31 pairs Cervical and lumbar enlargements The nerves serving the upper and lower limbs emerge here Cervical Cervical spinal nerves enlargement Dura and arachnoid Thoracic mater spinal nerves Lumbar enlargement Conus medullaris Lumbar Cauda spinal nerves equina Filum (a) The spinal cord and its nerve terminale Sacral roots, with the bony vertebral spinal nerves arches removed. The dura mater and arachnoid mater are cut open and reflected laterally. Figure 12.29a Spinal Cord Protection Bone, meninges, and CSF Spinal tap-inferior to second lumbar vertebra T12 Ligamentum flavum L5 Lumbar puncture needle entering subarachnoid space L4 Supra- spinous ligament L5 Filum terminale S1 Inter- Cauda equina vertebral Arachnoid Dura in subarachnoid disc matter mater space Figure 12.30 Spinal Cord Cross section Central gray matter Cortex of white matter Epidural -
Meninges Ventricles And
Meninges ,ventricles & CSF Dr.Sanaa Al-Shaarawy Dr. Essam Eldin Salama OBJECTIVES • By the end of the lecture the student should be able to: • Describe the cerebral meninges & list the main dural folds. • Describe the spinal meninges & locate the level of the termination of each of them. • Describe the importance of the subarachnoid space. • List the Ventricular system of the CNS and locate the site of each of them. • Describe the formation, circulation, drainage, and functions of the CSF. • Know some clinical point about the CSF MENINGES • The brain and spinal cord are invested by three concentric membranes ; • The outermost layer is the dura matter. • The middle layer is the arachnoid matter. • The innermost layer is the pia matter. DURA MATER ▪The cranial dura is a two layered tough, fibrous thick membrane that surrounds the brain. ▪It is formed of two layers; periosteal and meningeal. ▪The periosteal layer is attached to the skull. ▪The meningeal layer is folded forming the dural folds : falx cerebri, and tentorium cerebelli. ▪Sensory innervation of the dura is mostly from : meningeal branches of the trigeminal and vagus nerves & C1 to C3(upper cervical Ns.). DURA MATER Folds Two large reflection of dura extend into the cranial cavity : 1.The falx cerebri, In the midline, ▪It is a vertical sickle-shaped sheet of dura, extends from the cranial roof into the great longitudinal fissure between the two cerebral hemispheres. ▪It has an attached border adherent to the skull. ▪And a free border lies above the corpus callosum. DURA MATER Folds 2. A horizontal shelf of dura, The tentorium cerebelli, ▪ It lies between the posterior part of the cerebral hemispheres and the cerebellum. -
Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers
International Journal of Molecular Sciences Review Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers Mariana Castro Dias *, Josephine A. Mapunda, Mykhailo Vladymyrov and Britta Engelhardt * Theodor Kocher Institute, University of Bern, 3012 Bern, Switzerland; [email protected] (J.A.M.); [email protected] (M.V.) * Correspondence: [email protected] (M.C.D.); [email protected] (B.E.) Received: 14 October 2019; Accepted: 26 October 2019; Published: 29 October 2019 Abstract: The homeostasis of the central nervous system (CNS) is ensured by the endothelial, epithelial, mesothelial and glial brain barriers, which strictly control the passage of molecules, solutes and immune cells. While the endothelial blood-brain barrier (BBB) and the epithelial blood-cerebrospinal fluid barrier (BCSFB) have been extensively investigated, less is known about the epithelial and mesothelial arachnoid barrier and the glia limitans. Here, we summarize current knowledge of the cellular composition of the brain barriers with a specific focus on describing the molecular constituents of their junctional complexes. We propose that the brain barriers maintain CNS immune privilege by dividing the CNS into compartments that differ with regard to their role in immune surveillance of the CNS. We close by providing a brief overview on experimental tools allowing for reliable in vivo visualization of the brain barriers and their junctional complexes and thus the respective CNS compartments. Keywords: brain barriers; blood-brain barrier; neurovascular unit; blood-cerebrospinal fluid barrier; arachnoid barrier; glia limitans; tight junctions; adherens junctions 1. Introduction The brain barriers established by the endothelial blood-brain barrier (BBB), the epithelial blood-cerebrospinal fluid barrier (BCSFB), the meningeal brain barriers and the blood spinal cord barrier are essential for maintaining central nervous system (CNS) homeostasis [1]. -
Lecture 4: the Meninges And
1/1/2016 Introduction • Protection of the brain – Bone (skull) The Nervous System – Membranes (meninges) – Watery cushion (cerebrospinal fluid) – Blood-brain barrier (astrocytes) Meninges CSF The Meninges The Meninges • Series of membranes • Three layers • Cover and protect the CNS – Dura mater • Anchor and cushion the brain – Arachnoid mater – • Contain cerebrospinal fluid (CSF) Pia mater The Meninges • Dura mater – “Tough mother” Skin of scalp Periosteum – Strongest meninx Bone of skull Periosteal Dura – Fibrous connective tissue Meningeal mater Superior Arachnoid mater – sagittal sinus Pia mater Limit excessive movement of the brain Subdural Arachnoid villus – space Blood vessel Forms partitions in the skull Subarachnoid Falx cerebri space (in longitudinal fissure only) Figure 12.24 1 1/1/2016 Superior The Meninges sagittal sinus Falx cerebri • Arachnoid mater – “Spider mother” Straight sinus – Middle layer with weblike extensions Crista galli – Separated from the dura mater by the subdural space of the Tentorium ethmoid cerebelli – Subarachnoid space contains CSF and blood vessels bone Falx Pituitary cerebelli gland (a) Dural septa Figure 12.25a The Meninges • Pia mater – “Gentle mother” – Connected to the dura mater by projections from the arachnoid mater – Layer of delicate vascularized connective tissue – Clings tightly to the brain T Meningitis TT121212 Ligamentum flavumflavumflavum L • LL555 Lumbar puncture Inflammation of meninges needle entering subarachnoid • May be bacterial or viral spacespacespace LLL444 • Diagnosed by