MOLECULAR PHARMACOLOGY, 18, 611-615

AUTHOR INDEX FOR VOLUME 18

A Chang, Larry. See Pang, Braswell, Sommer, and Miller, 84 Changuex, Jean-Pierre. See Waksman and Roques, 20 Adler, A. See Scheibel, 320 Chao, Haiyen. See Chung, 543 Agrawal, Krishna C. See Preidecker, Sartorelli, and Moore, 507 Charnock, J. S., Gibson, R. A., McMurchie, E. J., and Raison, J. Agresti, Aleasandro, Bu.ffoni, Franca, Kaufman, Joyce J., and K. Changes in the Fluidity of Myocardial Membranes during Petrongolo, Carlo. Strudure-Activity Relationships of Eser- Hibernation: Relationship to Myocardial Adenosinetriphospha- oline and Morphine: Ab Initio Quantum-Chemical Study of the tase Activity, 476 Electrostatic Potential of the Interaction Energy with Water, Chello, Paul L, Sirotnak, Francis M., and Dorick, Diane M. 461 Alterations in the Kinetics of Methotrexate Transport during Aitio, Antero. See Felton, Ketley, Jakoby, Bend, and Nebert, 559 Growth of L1210 Murine Leukemia Cells in Culture, 274 Anjaneyulu, Kowluru. See Couturier, Sener, and Malaisse, 243 Chen, Beatrice P. See Wei and Rice, 497 Albuquerque, Edson X., Teal, Ming-Cheng, Aronstam, Robert Chuang, De-Maw, Kin.nier, William J., Farber, Len, and Costa, S., Eldefrawi, Amira T., and Eldefrawi, Mohyee E. Sites of Ermino. A Biochemical Study of Receptor Internalization dur- Action of Phencyclidine. II. Interaction with the Ionic Channel ing $-Adrenergic Receptor Desensitization in Frog Erythrocytes, of the Nicotinic Receptor, 167; See also Tsai, Aronstam, Elde. 348 frawi, Eldefrawi and Triggle, 159; Aronstam, Eldefrawi, Elde- Chuang, Linda F. See Kawahata, Holmberg, Osburn, and Chuang, frawi, Jim, and Triggle, 179; Spivak, 384 503 Armstrong, Joyce A, Marks, Gerald S., and Armstrong, Paul W. Chuang, Ronald Y. See Kawahata, Holmberg, Osburn, and Chuang, Absence of Metabolite Formation during Nitroglycerin-Induced 503 Relaxation of Isolated Blood Vessels, 112 Cheng, Yung-Chi. See Caradonna, 573 Armstrong, Paul W. See Annstrong and Marks, 112 Chrystal, Ewan J. T., Koch, Ronald L, and Goldman, Peter. Aronstam, Robert S., Eldefrawi, Mohyee E., Eldefrawi, Amira Metabolites from the Reduction of Metronidazole by Xanthine T., Albuquerque, Edson X., Jim, Kam F., and Triggle, Oxidase, 105 David J. Sites of Action of Phencycidine. III. Interactions with Chung, Leland W. K. and Chao, Haiyen. Neonatal Imprinting and Muscarinic Receptors, 179; See aLso Tsai, Albuquerque, Elde- Hepatic Cytochrome P.450 I. Comparison of Testosterone Hy- frawi, Eldefrawi, and Trile, 15fr, Albuquerque, Tsai, Elde- droxylation in a Reconstituted System between Neonatally Im- frawi, and Eldefrawi, 167 printed and Nonimprinted Rats, 543 Asakura, Mikio. See Shi,na, Kawashima, Hirai, and Kouyama, 45 Cooper, Dermot M. F., Londos, Constantine, and Rodbell, Mar- Askari, Amir. See Huang, 53 tin. Adenosine Receptor-Mediated Inhibition of Rat Cerebral Aten, Raymond R. See Dickson and Eisenfeld, 215 Cortical Adenylate Cyclase by a GTP-Dependent Process, 598 Attie, M. F. See Brown, Reen, Gardner, Kebabian, and Aurbach, 335 Corcoran, G. B., Mitchell, J. R., Vaislmav, Y. N., and Horning, E. Aurbach, G. D. See Brown, Attie, Reen, Gardner, and Kebabian, 335 C. Evidence That Acetaminophen and N-Hydroxyacetamino- B phen Form a Common Arylating Intermediate, N-Acetyl-p-Ben- zoquinoneimine, 536 Baldwin, Sheryl, Kier, Lemont B., and Shillady, Donald. Approx- Costa, Erminio. See Chuang, Kinnier, and Farber, 348 imate Molecular Potentials of Mescaline Analogues in a Study Couturier, Etienne, Sener, AbdUllah, Anjaneyulu, Kowluru, and of Similarities to 5-Hydroxytryptamine, 455 Malaisse, Willy J. Inhibition by Quinine of Insulin Release and Barbin, G., Palacios, J. M., Rodergas, E., Schwartz, J. and C., Calcium lonophoresis, 243 Garbarg, M. Characterization of the High-Affinity Binding Dahlig, Ewa. See Paterson, Lau, and Cass, 40 Sites of [3H]Histamine in Rat Brain, 1 Danenberg, Peter V. See Sarrif, Tone, and Heidelberger, 148 Baron, Jeffrey. See Taira, Greenspan, Kapke, and Redick, 304 Davis, James N., Olender, Edward, Maury, Wendy, and Mc- Barone, Vincenzo, Lelj, Francesco, and Russo, Nino. Conforma- Daniel, Robert. a-Adrenergic Regulation of Cholinergic Re- of N-($-Actoxyethyl)Pyridinium Ion: Compari- tional Analysis sponses in Rat Parotid Acinar Cells, 356 sions with Acetylcholine, 331 Dickson, Robert B., Aten, Raymond R., and Eisenfeld, Arnold J. Beerman, Terry A. See Woynarowski, 491 Receptor-Bound Estrogens and Their Metabolites in the Nu- Bend, John R. See Felton, Ketley, Jakoby, Aitio, and Nebert, 559 cleus of Isolated Rat Liver Parenchymal Cell, 215 Boatman, Rodney J. See Poland, Mak, Glover, Ebetino, and Kende, DiStefano, Victor. See Ducis, 438; 447 571 Dorick, Diane M. See Chello and Sirotnak, 274 Braswell, Leon M. See Pang, Chang, Sommer, and Miller, 84 Duch, David S., Edeistein, Mark P., and Nichol, Charles A. Bresnick, Edward, Hassuk, Bruce, Liberator, Paul, Levin, Inhibition of Histamine-Metabolizing Enzymes and Elevation of Wayne, and Thomas, Paul E. Nucleolar Cytochrome P-450, Histamine Levels in Tissues by Lipid-Soluble Anticancer Folate 550 Antagonists, 100 Browing, Edward T. See Groppi, 427 Ducis, tize, and DiStefano, Victor. Evidence for a Serotonin Uptake Brown, E. M., Attie, M. F., Reen, S., Gardner, D. G., Kebabian, System in Isolated Bovine Pinealocyte Suspensions, 438 J., and Aurbach, G. D. Characterization of Dopaminergic Ducis, llze, and DiStefano, Victor. Characterization of Serotonin Receptors in Dispersed Bovine Parathyroid Cells, 335 Uptake in Isolated Bovine Pinealocyte Suspensions, 447 Buffoni, Franca. See Agresti, Kaufman, and Petrongolo, 461 Duell, Elizabeth A. Adenosine-Induced Alterations in the Adenosine Butcher, Reginald W. See Nemecek and Wells, 57 3’:S’-Monophosphate Levels in Mammalian Epidermis, 49 Dybmg, Erik. See Wirth, von Ba/cr, and Thorgeirsson, 117 C

Caradonna, Salvatore J. and Cheng, Yung-Chi. The Role of Deox- E yuridine Triphosphate Nucleotidohydrolase, Uracil-DNA Gly- cosylase, and DNA Polymerase a in the Metabolism of FUdR in Ebetino, Frank H. See Poland, Mak, Glover, Boatman, and Kende, Human Tumor Cells, 573 571 Case, Carol E. See Paterson, Lau, and Dah!ig, 40 Edelstein, Mark P. See Duch and Nichol, 100

Copyright © 1980 by The American Society for Pharmacology and Experimental Therapeutics 611 All rights of reproduction in any form reserved. 612 AUTHOR INDEX

Eleenfeld, Arnold J. See Dickson and Aten, 215 Harrelson, Wifiard G. Jr., See Wolf, Nastainczyk, Phi4x,t, Kaly- Eldefrawi, Amira T. See T8ai, Albuquerque, Aronstam, Eldefrawi, anaraman, and Mason, 553 and Trggle, 159; Albuquerque, Tsai, Aronstam, and Eldefrawi, Hartman, Kathleen D. See Glazer, 483 167; Aronstam, Eldefrawi, Albuquerque, Jim, and 7-igg1e, 179 Hassuk, Bruce. See Bresnick, Liberator, Levin, and Thomas, 550 Eldefrawi, Mohyee E. See T8ai, Albuquerque, Aronstam, Eldefrawi, Heidelberger, Charles. See Sarrif, Tone, and Danenberg, 148 and Thggle, 159; Albuquerque, Tsai, Aronstam, and Eldefrawi, Herz, Albert. See Schulz, Wuster, and Krenss, 395 167; Aronstam, Eldefrawi, Albuquerque, Jim, and Triggle, 179 Hirai, Masanao. See Shima, Kawashima, Asahura, and Kouyama, Erdos, Joseph J. and Maguire, Michael E. Independent Desensiti- 45 zation of fI-Adrenergic Receptor-Regulated Magnesium Trans- Holmberg, Charles A. SeeKawahata, Osburn, Chuang, and Chuang, port and Cyclic AMP Accumulation, 379 503 Holz, Ronald W. Correlation of the Effects of Bretylium, Guanethi- F dine, and N,N-Diisopropyl-N’-Isoamyl-N’-Diethyla.minoethylu-

Fain, John N. See Gdrcia-Sdinz, 72 rea (P-286) on the W Electrochemical Gradient across the FairChild, Edward H. See Tracy, Lucas, and Webster, 313 Chromaffin Granule Membrane and on ChrOmaffin Granule Farber, Len. See Chuang, Kinnier, and Costa, 348 Function, 606 Faulkner, Robert. See Huang, 267 Horning, E. C. See Corcoran, Mitchell, and Vaishnav, 536 Felton, James S., Ketley, Jeanne N., Jakoby, William B., Aitio, Huang, Rose H. and Faulkner, RObert. Lipid-Protein Interactions Antero, Bend, John R., and Nebert, Daniel W. Hepatic in the Multiple Forms of Monoamine Oxidases: Lipases as Glutathione Transferase Activity Induced by Polycycic Aro- Probes Using Purified Intact Rat Brain Mitochondria, 267 matic Compounds. Lack of Correlation with the Murine Ah Huang, Wu-Hsiung and Askari, Amir. Ouabain-Induced Changes Locus, 559 in the Tertiary and the Quaternary Conformations of (Na + Freychet, Pierre. See Kitabgi, Poustis, Granier, Van Rietschoten, K)-Activated Adenosine Triphosphatase, 53 Rivier, and Morgat, 11 J

G Jackson, RObert C. Modulation of Methotrexate Toxicity by Thy- Garbarg, M. See Barbin, Palacios, Rodergas, and Schwartz, 1 midine: Sequence-Dependent Biochemical Effects, 281 Garcia-Suinz, J. Adolfo and Fain, John N. Effect of Adrenergic Jakoby, William B. See Felton, Ketley, Aitio, Bend, and Nebert, 559 Amines on Phosphatidylinositol Labeling and Glycogen Syn- Jergil, Bengt. See Schelin, Tunek, and Jerstrom, 529 these Activity in Fat Cells from Euthyroid and Hypothyroid Jerstrom, Bengt. See Schelin, Tunek, and Jergil, 529 Rats, 72 Jim, Kam F. See Aronstarn, Eldefrawi, Eldefrawi, Albuquerque, and Gardner, D. G. See Brown, Attic, Reen, Kebabian, and Aurbach, 335 Triggle, 179 Gibson, R. A. See Charnock, McMurchie, and Raison, 476 Johnson, Eric F. See Liem and Muller-Eberhard, 565 Glazer, RObert I. and Hartman, Kathleen D. Evidence That the Jones, Lynne M. See Hanky, Lee, and Michell, 78 Inhibitory Effect of Adenosine, but Not Cordyceptm, on the Methylation of Nuclear RNA is Mediated by S-Adenosylhomo- K cystein Hydrolase, 483 Kalyanaraman, B. See Wolf, Harrelson, Nastainczyk, Philpot, and Glover, Edward. See Poland, Mak, Boatman, Ebetino, and Kende, Mason, 553 571 Kapke, Gordon F. See Taira, Greenspan, Redick, and Baron, 304 Goldman, Peter, See C/crystal and Koch, 105 Katzenellenbogen, Benita S. See Pavlik, 406 Gordon, Paul B. See Seglen, 468 Kaufnian, Joyce J. See Agresti, Buffoni, and Petrongolo, 461 Graham, Doyle G. See Patton, Rosen, Rauckman, Small, and Ziegler, Kawahata, Russell T., Holmberg, Charles A., Osburn, Bennie L, 151 Chuang, Linda F., and Chuang, Ronald Y. Effect of 6-Mer- Granier, Claude. See Kitabgi, Poustis, Van Rietschoten, Rivier, captopurine Ribonucleotides on DNA-Dependent RNA Polym- Morgat, and Freychet, 11 erase Activity, 503 Greco, William IL and Hakala, Marie T. Biochemical Pharmacology Kawashima, Yoshiko. See Shima, Hirai, Asakura, and Kouyama, of Lipophilic Diaminopyrimidine Antifolates in Mouse and Hu- 45 521 man Cells in Vitro, Kebabian, J. See Brown, Attie, Reen, Gardner, and Aurbach, 335 Greenspan, Phillip. See Taira, Kapke, Redick, and Baron, 304 Kende, Andrew S. See Poland, Mak, Glover, Boatman, and Ebetino, Groppi, Vincent E. Jr., and Browing, Edward T. Norepinephrine- 571 Dependent Protein Phosphorylation in Intact C-6 Glioma Cells. Ketley, Jeanne N. See Felton, Jakoby, Aitio, Bend, and Nebert, 559 Analysis by Two-Dimensional Gel Electrophoresis, 427 Kier, Lemont B. See Baldwin and Shillady, 455 Gupta, Radhey S., Krepinsky, Jiri J., and Siminovitch, Louis. Kim, Ryung-soon (Song), LaBella, Frank S., Zunza, Hilda, Structural Determinants Responsible for the Biological Activity Zunka, Federika, and Templeton, John F. Progesterone of (-)-Emetine, (-)-Cryptopleurine, and (-)-Tylocrebrine: Derivatives that Bind to the Digitalis Receptor: Structure-Ac- Structure-Activity Relationship among Related Compounds, tivity Relationships, 402 136 Kinnier, William J. See Chuang, Farber, and Costa, 348 Gurtoo, Hira L Genetic Expressions of Aflatoxin B Metabolism: Kitabgi, Patrick, Poustis, Claudine, Granier, Claude, Van Riet- Effects of 3-Methylcholanthrene and 2,3,7,8-Tetrachlorodi- schoten, Jurphaas, Rivier, Jean, Morgat, Jean-Louis, and benzo-p-dioxin on the Metabolism ofAflatoxins by B1 and B2 by Freychet, Pierre. Neurotensin Binding to Extraneural and Various Inbred Strains of Mice, 296 Neural Receptors: Comparison with Biological Activity and Structure-Activity Relationships, 11 H Kober, Anita, Olsson, Ylva, and Sj#{246}holm, Ingvar. Binding of Hakala, Marie T. See Greco, 521 Drugs to Human Serum Albumin. XIV. The Theoretical Basis Hanin, Israel. See Mantione, 28 for the Interaction between Phenytoin and Valproate, 237 Hanley, Michael R., Lee, C. M., Jones, Lynne M., and Michell, Kober, Anita and Sj#{246}holm, Ingvar. The Binding Sites on Human Robert H. Similar Effects of Substance P and Related Peptides Serum Albumin for Some Nonsteroidal Antiinflammatory on Salivation and on Phosphatidylinositol Turnover in Rat Drugs, 421 Salivary Glands, 78 Koch, Ronald L See Ch,ystal and Goldman, 105 AUTHOR INDEX 613

N Koontz, John N. and Wicks, Wesley D. Cytotoxic Effects of Two Novel 8-Substituted Cyclic Nucleotide Derivatives in Cultured Nandli, Dhirendra L and Okita, George T. Effects ofSodium Iodide, Rat Hepatoma Cells, 65 Lithium Bromide, and Deoxycholate on Dissociation of [3H]- Kouyama, Hiroshi. See Shima, Kawashima, Hirai, and Asakura, 45 Ouabain-Na,K-ATPase Complex during Enzyme Isolation, 259 Krenss, Heinz See Schulz, Wisster, and Herz, 395 Nastainczyk, Wolfgang M. See Wolf, Harrelson, Philpot, Kalyanar- Krepinsky, Jiri L See Gupta and Siminovitch, 136 aman, and Mason, 553 Kunze, Kent L See Ortiz de Montellano and Mico, 602 Nathanson, James A. $-Adrenergic-Sensitive Adenylate Cyclase in Kwok, Y. C. and Moore, G. J. Affinity Labeling of Angiotensin II Choroid Plexus: Properties and Cellular Localization, 199 Receptors in the Isolated Rat Uterus with Photolabile Antago- Nebert, Daniel W. See Felton, Ketley, Jakoby, AitiO, and Bend, 559 mit, 210 Neet, Kenneth. See Meisner and Stair, 230 L Neilson, I. R., Singer, M. A., and Marks, G. S. Association between the Membrane-Fluidizing Properties of Porphyrin-Inducing Ac- Labella, Frank S. See Kim, Zunza, Zunka, and Templeton, 402 tivity of Al.faxolone and Related Steroids, 144 Lan, Christopher and Slotkin, Theodore A. Regulation of Ornithine Nemecek, Georgina M., Wells, Jack N., and Butcher, Reginald Decarboxylase Activity in the Developing Heart of Euthyroid or W. Inhibition of Fibroblast Cyclic AMP Escape and Cyclic Hyperthyroid Rats, 247 Nucleotide Phosphothesterase Activities by Xanthines, 57 Lau, Eda Y. See Paterson, Dahlig, and Cass, 40 Nichol, Charles A. See Duch and Edelstein, 100 Lee, C. M. See Hanky, Jones, and Michell, 78 Leighton, H. J. See Waggoner and McDermed, 91 0 Lelj, Francesco. See Barone and Russo, 331 Okita, George T. See Nandi, 259 Levin, Wayne. See Bresnick, Hassuk, Liberator and Thomas, 550 Olender, Edward. See Davis, Maury, and McDaniel, 356 Liberator, Paul. See Bresnick, Hassuk, Levin, and Thomas, 550 Olsson, Ylva. See Kober and Sj#{246}holm, 237 Liem, Heng H., Muller-Eberhard, Ursula, and Johnson, Eric F. Ortiz de Montellano, Paul R. and Mico, Bruce A. Destruction of Differential Induction by 2,3,7,8-Tetrachlorodibenzo-p-dioxin of Multiple Forms of Rabbit Microsomal Cytochrome P-450: Evi- Cytochrome P-450 by Ethylene and Other Olefins, 128 dence for Tissue Specificity, 565 Ortiz de Montellano, Paul R., Kunze, Kent L, and Mico, Bruce Londos, Constantine. See Cooper and Rodbell, 598 A. Destruction of Cytochrome P-450 by Olefms: N-Alkylation of Lucas, Samuel V. See Tracy, Fairchild, and Webster, 313 Prosthetic Heme, 602 Osburn, Bennie I. See Kawahata, Holmberg, Chuang, and Chuang, M 503

Maguire, Michael E See Vaugulin, 362; Erdos, 379 P Mak, Ivan. See Poland, Glover, Boatman, Ebetino, and Kende, 571 Malaisse, Wffly J. See Couturier, Sener, and Anjaneyulu, 243 Palacios, J. M. See Barbin, Rodergas, Schwartz, and Garbarg, 1 Malbon, Craig C. The Effects of Thyroid Status on the Modulation Pang, Kam-Yee Y., Braswell, Leon M., Chang, Larry, Sommer, of Fat Cell f-Adrenergic Receptor Agonist Affinity by Guanine Toby J., and Miller, Keith W. The Perturbation of Lipid Nucleotides, 193 Bilayers by General Anesthetics: A Quantitative Test of the Mantione, Charles R. and Hanin, Israel. Further Characterization Disordered Lipid Hypothesis, 84 of Human Red Blood Cell Membrane Cholinergic Receptors, 28 Paterson, Alan R. P., Lau, Eda Y., Dahlig, Ewa, and Cass, Carol Marks, Gerald S. See Armstrong and Armstrong, 112; Neilson and E. A Common Basis for Inhibition of Nucleoside Transport by Singer, 144 Dipyridamole and Nitrobenzylthioinosine?, 40 Mason, Ronald P. See Wolf, Harrelson, Nastainczyk, Philpot, and Patton, Suzanne E., Rosen, Gerald M., Rauckman, Elmer J., Kalyanaraman, 553; Perez-Reyes, 594 Graham, Doyle G., Small, Barbara, and Ziegler, Daniel M. Maury, Wendy. See Davis, Olender, and McDaniel, 356 Hamster Hepatic Nuclear Mixed-Function Amine Oxidase: Lo- McDaniel, Robert. See Davis, Olender, and Mau,y, 356 cation and Specific Activity, 151 McDermed, John. See Waggoner and Leighton, 91 Patton, Suzanne E., Rosen, Gerald M., and Rauckman, Elmer J. McLennan, Ian. See Tomlinson and Mutus, 33 Superoxide Production by Purified Hamster Hepatic Nuclei, 588 McMurchie, E. J. See Charnock, Gibson, and Raison, 476 Pavlik, Edward J. and Katzenellenbogen, Bemta S. The Stability Meisner, Herman. Binding of Anionic Uganda to Peptic Fragments of the Uterine Estrogen Receptor When Complexed with Estro- of Bovine Serum Albumin, 224 gens or Antiestrogens, 406 Meisner, Herman, Stair, James, and Neet, Kenneth. Quantitative Perez-Reyes, Edward and Mason, Ronald P. Electron Spin Reso- Assessment of the Competitive Binding of Anionic Uganda to nance Study of the Autoxidation of 6-Aminodopamine, 594 Albumin, 230 Petrongolo, Carlo. See Agresti, Buffoni, and Kaufman, 461 Michell, Robert H. See Hanky, Lee, and Jones, 78 Philpot, Richard M. See Wolf, Harrelson, Nastainczyk, Kalayanar. Mico, Bruce A. See Ortiz de Montellano, 128; Ortiz de Montellano aman, and Mason, 553 and Kunze, 602 Poirier, M. C., Williams, G. M., and Yuspa, S. H. Effect of Culture Miller, Keith W. See Pang, Braswell, C/cong. and Sommer, 84 Conditions, Cell Type, and Species of Origin on the Distribution Mitchell, J. R. See Corcoran, Vaishnav, and Horning, 536 of Acetylated and Deacetylated Deoxyguanosine C-8 Adducts of Minneman, Kenneth P. See Weiland and Molinoff, 341 N-Acetoxy-2-acetylaminofluorene, 581 Molinoff, Perry B. See Weiland and Minneman, 341 Poland, Alan, Mak, Ivan, Glover, Edward, Boatman, Rodney, J., Moore, E. Colleen. See Preidecker, Agrawal, and Sartorelli, 507 Ebetino, Frank H., and Kende, Andrew S. 1,4-Bis [2-(3,5- Moore, G. J. See Kwok, 210 Dichloropyridyloxy)] benzene, a Potent Phenobarbital-like In- Morgat, Jean-Louis. See Kitabgi, Poustis, Granier, Van Rietschoten, ducer of Microsomal Monooxygenase Activity, 571 Rivier, and Freychet, 11 Poustis, Claudine. See Kitabgi, Granier, Van Rietschoten, Rivier, Morishima, Isao, Thompson, W. Joseph, Robison, G. Alan, and Morgat, and Freychet, 11 Strada, Samuel J. Loss and Restoration of Sensitivity to Preidecker, Paul J., Agrawal, Krishna C., Sartorelli, Alan C., Epinephrine in Cultured BHK Cells: Effect of Inhibitors of RNA and Moore, E. Colleen. Effects of the Ferrous Chelate and Protein Synthesis, 370 of 4-Methyl-5-amino-1-formylisoquinoline Thiosemicarbazone Muller-Eberhard, Ursula. See Liem and Johnson, 565 (MAIQ-1) on the Kinetics of Reduction of CDP by Ribonucleo- Mutus, Bulent. See Tomlinson and McLennan, 33 tide Reductase of the Novikoff Tumor, 507 614 AUTHOR INDEX

R T

Raess, Beat U. and Vincenzi, Frank F. Calmodulin Activation of Taira, Yoshitsugi, Greenspan, Philip, Kapke, Gordon F., Re- Red Blood Cell (Ca2 + Mg)-ATPase and Its Antagonism by dick, Jan A., and Baron, Jeffrey. Effects of Phenobarbital, Phenothiazines, 253 Pregnenolone-16 a-Carbonitrile, and 3-Methylcholanthrene Pro- Raison, J. K. See Charnock, Gibson, and McMurchie, 476 treatments on the Distribution of NADPH-Cytochrome c (P. Rauckman, Elmer J. See Patton, Rosen, Graham, Small, and Zie- 450) Reductase within the Liver Lobule, 304 gler, 151; Patton and Rosen, 588 Taylor, Dermot B. See Spivak, 413 Redick, Jan A. See Taira, Greenspan, Kapke, and Baron, 304 Templeton, John F. See Kim, LaBella, Zunza, and Zunka, 402 Reen, S. See Brown, Attie, Gardner, Kebabian, and Aurbach, 335 Thomas, Paul E. See Bresnick, Hassuk, Liberator, and Levin, 550 Rice, Jerry M. See Wei and Chen, 497 Thompson, W. Joseph. See Morishima, Robison, and Strada, 370 Rivier, Jean. See Kitabgi, Poustis, Granier, Van Rietschoten, Mor- Thorgeirsson, Snorri S. See Wirth, Dybing, and von Ba/cr, 117 gat, and Freychet, 11 Tomlinson, George, Mutus, Bulent, and McLennan, Ian. Modu- Robins, Roland K. See Willis and Seegmiller, 287 lation of Acetylcholinesterase Activity by Peripheral Site Lig- Robison, G. Alan. See Morishima, Thompson, and Strada, 370 ands,33 Rodbell, Martin. See Cooper and Londos, 598 Tone, Hiroshi. See Sarrif, Danenberg, and Heidelberger, 148 Rodergas, E. See Barbin, Palacios, Schwartz, and Garbarg, 1 Tracy, James W., Fairchild, Edward H., Lucas, Samuel V., and Roeske, William IL See Ywnada and Yamamura, 185 Webster, Leslie T. Jr., Isolation, Characterization, and Syn- Roques, Bernard P. See Waksman and Changeux, 20 thesis ofan Immunoregulatory Metabolite ofNiridazole: 1-Thio- Rosen, Gerald M. See Patton, Rauckman, Graham, Small, and catbomoyl-2-imidazolidinone, 313 Ziegler, 151; Patton and Rauckman, 558 Triggle, David J. See Tsai, Albuquerque, Aronstam, Eldefrawi, and Russo, Nmo. See Barone and Lelj, 331 Eldefrawi, 159; Aronstam, Eldefrawi, Eldefrawi, Albuquerque, andJim, 179 Tsai, Ming-Chen, Albuquerque, Edson X., Aronstam, RObert S., S Eldefrawi, Amira T., Eldefrawi, Mohyee E., and Triggle, Sart’if, Awni M., Tone, Hiroshi, Dandenberg, Peter V., and Hei- David J., Sites of Action of Phencycidine. I. Effects on the delberger, Charles. The Incorporation of Trifluorothymidine Electrical Excitability and Chemosensitive Properties of the into Calf Thymus DNA in a Cell-Free System Does Not Lead to Neuromuscular Junction of Skeletal Muscle, 159; See aLso Al- Chain Termination, 148 buquerque, Aronstam, Eldefrawi, and Eldefrawi, 167 Sartorelli, Alan C. See Preidecker, Agrawal, and Moore, 507 Tunek, Andres. See Schelin, Jerstr#{244}m, and Jergil, 529 Sato, Paul H. Synthesis of Ascorbic Acid in Guinea Pigs by an Implanted Dialysis Bag Containing L-GulonolactOne Oxidase, 326 V Scheibel, L W. and Adler, A. Antimalarial Activity of Selected Vaishnav, Y. N. See Corcoran, Mitchell, and Horning, 536 Aromatic Chelators, 320 Van Rietschoten, Jurphaas. See Kitabgi, Poustis, Granier, Rivier, Schelin, Cecifia, Tunek, Andres, Jerstr#{246}m, Bengt, and Jergil, Morgat, and Freychet, 11 Bengt. Irreversible Binding of Isolated Benzo[a]pyrene Metab- Vauguelin, Georges and Maguire, Michael E. Inactivation of 6- olites to Specific Rat Liver Microsomal Proteins, 529 Adrenergic Receptors by N-Ethyhnaleimide in 849 Lymphoma Schulz, Rudiger, W#{252}ster, Michael, Krenss, Heinz, and Hera, Cells. Agonist Induction of Functional Receptor Heterogeneity, Albert. Lack of Cross-Tolerance on Multiple Opiate Receptors 362 in the Mouse Vas Deferens, 395 Vincenzi, Frank F. See Raess, 253 Schwartz, J. C. See Barbin, Palacios, Rodergas, and Garbarg, 1 von Bahr, Christer. See Wirth, Dybing, and Thorgeirsson, 117 Seegmiller, J. Edwin. See Willis and Robins, 287 Seglen, Per 0. and Gordon, Paul B. Effects of Lysosomotropic W Monoamines, Diamines, Amino Alcohols, and Other Amino Compounds on Protein Degradation and Protein Synthesis in Waggoner, W. G., McDermed, John, and Leighton, H. J. Presyn- Isolated Rat Hepatocytes, 468 aptic Regulation of Tyrosine Hydroxylase Activity in Rat Stria- Sener, AbdUllah. See Couturier, Anjaneyulu, and Malaisse, 243 ta.l Synaptosomes by Dopamine Analogs, 91 Shillady, Donald. See Baldwin and Kier, 455 Waksman, Gifies, Changeux, Jean-Pierre, and Roques, Bernard Shima, Sumio, Kawashima, Yoshiko, Hirai, Masanao, Asakura, P. Structural Requirements for Agonist and Noncompetitive Mikio, and Kouyama, Hiroshi. Effects of Androgens on Iso- Blocking Action of Acylcholine Derivatives on Electrophorus proterenol-Sensitive Adenylate Cyclase System of the Rat Pros- electricus Electroplaque 20 tate, 45 Webster, Leslie T. Jr., See Tracy, Fairchild, and Lucas, 313 Siminovitch, Louis. See Gupta and Krepinsky, 136 Wei, Shu-Jing, C., Chen, Beatrice P., and Rice, Jerry M. Compar- Singer, M. A. See Neilson and Marks, 144 ative Effects ofMethyl- and Ethylnitrosourea on DNA Directing Sirotnak, Francis M. See Chello and Dorick, 274 Cell-Free DNA-Dependent Synthesis of $-Galactosidase, 497 Sj#{246}holm, Ingvar. See Kober and Olsson, 237; Kober, 421 Weiland, Gregory A., Minneman, Kenneth P., and Molinoff, Slotkin, Theodore A. See Lau, 247 Perry B. Thermodynamics of Agonist and Antagonist Interac- Small, Barbara. See Patton, Rosen, Rauckman, Graham, and Zie- tions with Mammalian fl-Adrenergic Receptors, 341 gler, 151 Wells, Jack N. See Nemecek and Butcher, 57 Som.mer, Toby J. See Pang, Braswell, Chang, and Miller, 84 Wicks, Wesley D. See Koontz, 65 Spivak, Charles E. and Albuquerque, E. X. Anatoxin-a: A Novel, Williams, G. M. See Poirier and Yuspa, 581 Potent Agonist at the Nicotinic Receptor, 384 Willis, Randall C., Robins, Roland K., and Seegmiller, J. Edwin. Spivak, Charles E. and Taylor, Dermot B. Ion Exchange between An in Vivo and in Vitro Evaluation of 1-$-D-Ribofuranosyl-1,2,4- Agonist and Inorganic Ions at the Acetylcholine Receptor of triazole-3-carboxamicline: An Inhibitor of Human Lymphoblast Torpedo californica, 413 Purine Nucleoside Phosphorylase, 287 Stair, James. See Meisner and Neet, 230 Wirth, PeterJ., Eybing, Erik, von Bahr, Christer, and Thorgeirs- Strada, Samuel J. See Morishima, Thompson, and Robison, 370 son, Snorri S. Mechanism of N-Hydroxylacetylarylamine Mu- AUTHOR INDEX 615

tagenicity in the Salmonella Test System: Metabolic Activation Y of N-Hydroxyphenacetin by Liver and Kidney Fractions from Yamada, Shizuo, Yamamura, I., and Roeske, William R. Alters- Rat, Mouse, Hamster, and Man, 117 tions in Cardiac Autonomic Receptors following 6-Hydroxydo- Wolf, C. Roland, Harrelson, Wifiard G., Jr., Nastainczyk, Wolf- pamine Treatment in Rats, 185 gang M., Philpot, Richard M., Kalyanarainan, B., and Ma- Yamamura, Henry I. See Yamada, and Roeske, 185 son, Ronald P. Metabolism ofCarbon Tetrachloride in Hepatic Yuspa, R. H. See Poirier and Williams, 581 Microsomes and Reconstituted Monooxygenase Systems and Its Relationship to Lipid Peroxidation, 553 Z Woynarowski, Jan M. and Beerman, Terry A. Inhibition of DNA Ziegler, Daniel M. See Patton, Rosen, Rauckman, Graham, and Replication of HeLa S3 Cells by Macromomycin-I, an Antitumor Small, 151 Protein Antibiotic, 491 Zunka, Federika. See Kim, LaBella, Zunza, and Templeton, 402 W#{252}ster, Michael. See Schulz, Krenss, and Herz, 395 Zunza, Hilda. See Kim, LaBella, Zunka, and Templeton, 402 MOLECULAR PHARMACOLOGY, 18, 616-630

CUMULATIVE SUBJECT INDEX’ FOR VOLUMES 17 AND 18

A inhibition of methylation of nuclear RNA, mechanism (cell culture), 18, 483 Acetamide Adenosine kinase metabolite, from reduction of metronidazole by xanthine oxidase, 18, deficiency, human lymphoblast line, 18, 287 105 Adenosine 3’,5’-monophosphate Acetaminophen accumulation, ,8-adrenergic receptor-regulated: desensitization (lym- adduct formation, inhibition by ascorbate, 18, 536 phoma cells), 18, 379 arylating intermediate from, 18, 536 escape from fibroblasts, inhibition by xanthines (cell culture), 18, 57 covalent binding, inhibition by ascorbate, 18, 536 formation, prostate: effects of androgens (rat), 18, 45 N-Acetoxy-2-acetylaminofluorene in DNA adducts (cultured cells), 18, 581 generation, linked to $-adrenergic receptors, 17, 8 levels in N-($-Acetoxyethyl)pyridinium ion, conformational analysis: comparisons with acetylcholine, 18, 331 diaphragm (rat), 17, 73 2-Acetylaminofluorene-DNA epidermal strips, adenosine-induced alterations (human, mouse), 18, 49 binding, inhibition by paraoxon cell culture), 18, 581 rat N-Acetylarylamines mutagemcity, mechanism (bacteria), 18, 117 heart: cells, 17, 8; left atrium, 17, 180 lung cells, 17, 8 N-Acetylation arylamine drugs, 17, 367 relation to secretion in parathyroid cells (bovine), 18, 335 N-Acetyl-p-benzoquinoneimine from both acetaminophen and N-hydroxyacetaminophen, 18, 536 activity, myocardium: relationship to membrane fluidity during hi- bernation (ground squirrel), 18, 476 Acetylcholine chicken gizzard smooth muscle, 17, 66 comparison with conformational analysis of N-($-acetoxyethyl)- pyridinium ion, 18, 331 inhibition by modulator interacting agents, 17, 66 derivatives, agonist and blocking properties on electroplaque (electric Adenosinetriphosnhatase (Ca2 + Mg) human erythrocyte membranes, 18, 253 eel), 18, 20 phenothiazine inhibition, 18, 253 release, effects of 9-tetrahydrocaunabinol (frog), 17, 344 Acetylcholine receptor Adenosinetrisphosphatase (Na + K) dog kidney,18, 53 blockade by nereistoxin, 17, 127 rat brain, 17, 43 electric ray electric organ membranes, 17, 127, 283; 18, 167 ion exchange between agonists and inorganic ions at, 18, 413 subunit crosslinking, effects of ouabain, 18, 53 ionic channel, 17, 283; 18, 167; complex, 18, 384 Adenosinetriphosphatase (Na + Ki-[3H]ouabain complex, dissociation during enzyme isolation, heart (rabbit), 18, 259 mcotinic electric ray electroplax tissue, 18, 413 Adenosine triphosphate rat brain, 17, 149 cellular pools, labeling with 32P (glioma cells), 18, 427 Acetylcholinesterase S-Adenosylhomocysteine activity, modulation by peripheral site ligands (electric eel), 18, 33 inhibition of methylation of nuclear RNA (cell culture), 18, 483 inhibition by phenacycidine, 18, 159 S-Adenosylhomocysteine hydrolase N-Acetyltransferases in adenosine inhibition of methylation of nuclear RNA (cell culture), immunochemical studies (rabbit), 17, 367 18, 483 a1-Acid glycoprotein S-Adenosyl-L-methionine propranolol binding (human), 17, 187 in adenosine inhibition of methylation of nuclear RNA (cell culture), Actinomycin D 18, 483 effect on response of BHK cells to epinephrine, 18, 370 nuclear ribosomal RNA and poly(A) RNA synthesis, effect of 5- and spin-labeled derivatives, superoxide formation, 17, 432 azacytidine and dihydro-5-azacytidine (leukemia cells), 17, 111 Action potential Adenylate cyclase prolongation by phencyclidine, 18, 159 activation, and high and low affinity states of $-adrenergic receptor, Activator protein, see Protein 17, 14 Actodigin adenosine receptor-mediated inhibition by GTP-dependent process, crystal structure, 17, 43 18, 598 inhibition of Na,K-adenosinetriphosphatase, 17, 43 /1-adrenergic sensitive, choroid plexus (cat), 18, 199 Actodigin genin cat heart ventricular membranes, 17, 328 inhibition of Na,K-adenosinetriphosphatase, 17, 43 desensitization, 18, 379 Acylcholine frog erythrocytes, 18, 348 analogs, agonist and blocking properties on electroplaque (electric interaction with $-adrenergic receptors, 18, 362 eel), 18, 20 and internalization of$-adrenergic receptor recognition sites, 18,348 Adenosine rat analogs cerebral cortex, 18, 598 inhibition of adenylate cyclase (rat), 18, 598 heart, 17, 180 puromycin aminonucleoside, 17, 262 pancreas plasma membranes, 17, 268 -induced alterations in adenosine 3’,5’-monophosphate levels in epi- prostate, 18, 45 dermal strips, effects of psoriasis (human), 18,49 responsiveness

I Boldface numbers indicate appropriate volume; lightface numbers indicate pagination.

Copyright © 1980 by Academic Press, Inc. All right of reproduction in any form reserved. 616 SUBJECT INDEX 617

to catecholamines (BHK cells), 18, 370 Alfaxolone effect of hypothyroidism, 17, 180 association between membrane-fluidizing properties and porphyrin- S49 lymphoma cells, 18, 362, 379 inducing activity, embryo liver cells (chicken), 18, 144 system, isoproterenol sensitive: effects of androgens, 18,45 Algae turkey erythrocytes, 17, 163 blue-green, Anabaena flosaquae: anatoxin-a from, 18, 384 Adenylyl cyclase, see Adenylate cyclase Alkaline phosphatase Adipocyte, see Fat cells activity, vascular smooth muscle plasma membrane: effect of hyper- Adrenal tension (rat), 17, 137 medulla, localization of semidehvdroascorbate reductase (bovine), Amines 17, 421 lysosomotropic, effects on protein degradation and synthesis in hep- /1-Adrenergic drugs atocytes (rat), 18, 468 crystallographic and theoretical results: PCILO method. 17, 339 Amino acids key features, 17, 339 from protein degradation, 18,468 a-Adrenergic receptor 8-Aminoadenosine 3’,5’-monophosphate desensitization, 18, 356 cytotoxic effects in cultured hepatoma cells (rat), 18,65 rat parotid acinar cells, 18, 356 -y-Aminobutyric acid receptor ai-Adrenergic receptor binding, in cultured brain cells (mouse), 17, 285 effect on 6-Aminodopamine glycogen synthase activity in hypothyroidism (rat), 18, 72 autoxidation, 18, 594 phosphatidylinositol labeling in hypothyroidism (rat), 18, 72 &-Aminolevulinic acid 8-Adrenergic receptor incorporation into cytochrome P-450 heme (rat), 17, 395 agonist-induced transconformation, 17, 163 Amylase binding, prostate: effects of androgens (rat), 18,45 secretion, pancreas fragments: effect of guanyl nucleotides (rat), 17, cat heart: right and left atria and papillary muscles, 17, 328 268 effects of agonist interaction (BIlK cells), 18, 370 Anatoxin-a frog erythrocytes, 18, 348 nicotinic agonist, 18, 384 inactivation by N-ethylmaleimide, 18, 362 Androgen internalization during receptor desensitization, 18, 348 and castration, effects on isoproterenol-sensitive adenylate cyclase iodohydroxybenzylpindolol binding, 18, 341 system of prostate (rat), 18, 45 quantitative analysis, 17, 14 Androgen receptor rat inhibition by metal ions, 17, 156 cerebral cortex, cerebellum, heart, and lung, 18, 341 mouse prostate gland, 17, 156 fat cell membranes, 18, 193 Anesthetics -regulated magnesium transport and cyclic AMP accumulation, in- general dependent desensitization of, 18, 379 disordered lipid hypothesis of, 18, 84 S49 lymphoma cells, 18, 362, 379 perturbation of lipid bilayers by, 18,84 turkey erythrocyte, 17, 1; membranes, 17, 163 Angiotensin II receptors

P1 and / Adrenergic receptors photoaffinity labeling, 18, 210 criteria for classification, 17,8 rat uterus, 18, 210 mammal tissues, 17, 1 Antagonist rat heart and lung cells, 17, 8 binding, entropy increases of, 18, 341 $2Atheneic receptors folate, effect on histamine metabolism, 18, 100 adenylate cyclase, choroid plexus (cat), 18, 199 Anthracycline Adrenoceptor, see Adrenergic receptor antibiotics, interactions with xanthine oxidase (bovine), 17, 95 Affinity labeling free radicals, formation (bovine), 17, 95 angiotensin II receptors, with photolabile antagonist, 18, 210 interaction with covalently closed circular DNA (phage), 17, 100 Affinity states mechanism of action, 17, 100 /3-adrenergic receptor, resolution by computer modeling, 17, 14 Antiandrogen Aflatoxin effects on nuclear kinases (rat), 17, 212 B1 and B2, metabolism: genetic expression (mouse, inbred strains), Antibiotic 18, 296 antitumor protein, macromycin-I: inhibition of DNA replication Agonist (HeLa cells), 18, 491 acyl analogs of acetylcholine action as, structural requirements, 18, Anticancer 20 folate antagonists, effect on histamine metabolism, 18, 100 binding, entropy and enthalpy decreases of, 18, 341 Anticonvulsants induction of functional receptor heterogeneity, 18, 362 in metaphase arrest and microtubular polymerization, 17, 275 and inorganic ion exchange at acetylcholine receptor, 18, 413 Antiestrogens partial interaction with estrogen receptor, 18, 406 iodohydroxybenzylpindolol, cardiac tissues (cat), 17, 328 Antifolates nereistoxin, acetylcholine receptor, 17, 172 alteration of histamine metabolism, 18, 100 Albumin diaminopyrimidine, lipophilic: biochemical pharmacology in vitro ligand binding to, Scatchard analysis (bovine), 18, 230 (human, mouse), 18, 521 serum Anti-inflammatory drugs binding sites for nonsteroidal anti-inflammatory drugs, 18, 421 nonsteroidal, binding sites on serum albumin (human), 18, 421 drug binding, interaction between phenytoin and valproate (hu- Antimalarial man), 18, 237 activity, aromatic chelators, 18, 320 peptic fragments, anionic ligand binding (bovine), 18, 224 Antirheumatic drugs propranolol binding (human), 17, 187 binding sites on serum albumin (human), 18, 421 specificity of drug binding sites (human), 18, 157 Antitumor 618 SUBJECT INDEX

drugs, DNA damage after treatment with (virus), 17, 388 sites, high affinity: [H]histamine in brain (rat), 18, 1 protein antibiotic, macromycin-I: inhibition of DNA replication specific, to /3-adrenergic receptors in heart and lung (rat), 17, 8 (HeLa cells), 18, 491 Binding constants Aorta and antimalarial activity of aromatic chelators, 18, 320 strips: norepinephrine uptake, effect of phthalane and thiophthalane Bioassay inhibitors (rabbit), 17, 321 in vitro, intestinal smooth muscle (guinea pig), 18, 11 AR-L 57, see 6-(2,4-Dimethoxyphenyl)-imidazo-(4,5-fl)-pyridine 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene Aromatic chelators induction of monooxygenase activity in microsomes (mouse), 18, 571 antimalarial activity, 18, 320 Bleomycin Artery DNA damage after treatment with (virus), 17, 388 mesenteric, smooth muscle plasma membrane: effect of hypertension Blood on biochemistry (rat), 17, 137 platelets: serotonin secretion, effect of extracellular pH (rat), 17, 356 Aryl hydrocarbon hydroxylase, see Benzopyrene 3-monooxygenase Blood vessels 5-Aryltetrahydro-y-carboline helical strips, dorsal pedal arteries and medial saphenous veins: neuroleptic activity, conformational requirements for (rat), 17, 38 effects of nitroglycerin (dog), 18, 112 Ascorbic acid Bone inhibition of mutagenicity, N-hydroxyphenacetin and p-nitrosophe- calcium mobilization, effect of 1,24(R),25-trihydroxycholecalciferol netole (bacteria), 18, 117 (rat), 17, 362 synthesis in vivo, by implanted dialysis bag containing L-gulonolac- Brain tone oxidase (guinea pig), 18, 326 a-bungarotoxin receptor (rat), 17, 149 Atrium cells, cultured: -y-aminobutyric acid receptor binding (mouse), 17,285 adenylate cyclase system, effect of hypothyroidism (rat), 17, 180 cerebrum, cortex Autonomic receptors adenylate cyclase: adenosine receptor-mediated inhibition by heart, alterations after 6-hydroxydopamine (rat), 18, 185 GTP-dependent process, 18, 598 Autoxidation cyclic nucleotide phosphodiesterase activation by gangliosides 6-aminodopamine, 18, 594 (rat), 17, 206 Axon dopamine receptors, conformational requirements for interaction sodium pump, inhibition by AR-L 57 (squid), 17, 350 with (rat), 17, 38 Axoplasm high-affinity binding sites of [3H]histamine (rat), 18, 1 transport, fast: inhibition by delayed neurotoxic organophosphorus lipid bilayers, chronic ethanol effect (mouse), 17, 52 esters (rat), 17, 56 membranes, physical state: effect on phosphatidylserine requirement AY-22,241, see Actodigin for opiate binding (rat), 17, 290 5-Azacytidine mitochondria effects on nuclear RNA (leukemia cells), 17, 250 lipid-protein interactions in monoamine oxidase in situ (rat), 17, Azapropazone 192 binding sites on serum albumin (human), 18, 421 monoamine oxidases A and B (rat), 18, 267 monooxygenase activities, heme-mediated stimulation (rabbit), 17, B 225 nicotinic receptor, affinity reagents for (rat), 17, 149 Bacteria striatum Escherichia coli: RNA polymerase, effect of 6-mercaptopurine n- muscarinic receptor, [3H]quinuclidinyl benzilate binding (rat), 17, bonucleotides, 18, 503 24 Salmonella typhimurium, mutagenicity of N-hydroxyacetylarylam- synaptosomes: presynaptic regulation of tyrosine hydroxylase ac- ine, 18, 117 tivity by dopamine analogs (rat), 18, 91 Bacteriophage synaptic membranes, neurotensin binding (rat), 18, 11 covalently closed circular DNA, 17, 100 PM-2, Bretylium Benzo[a]pyrene effects on chromaffin granule function, 18, 606 metabolism (rabbit), 17, 225 Bromoacetylcholine metabolites, binding to liver microsome proteins (rat), 18, 529 receptor alkylation with (rat), 17, 149 Benzopyrene 3-monooxygenase a-Bungarotoxin in glutathione transferase not associated with Ah locus (mouse), 18, binding 559 to acetylcholine receptors, inhibition by nereistoxin (electric ray), Benzo[a]pyrene 4,5-oxide 17, 172 substrate for liver glutathione transferase (mouse), 18, 559 inhibition, 18, 159 BHK cells, see Fibroblasts; Kidney receptor (acetylcholine) saturation, 18, 413 Bicycic inhibitors a-Bungarotoxin receptor of norepinephrine uptake, 17, 321 rat brain, 17, 149 Binding anionic ligands to serum albumin fragments (bovine), 18, 224 C competitive, anionic ligands to albumin, 18, 230 Calcium drugs, to serum albumin: interaction between phenytoin and val- accumulation, vascular smooth muscle plasma membrane: effect of proate (human), 18, 237 hypertension (rat), 17, 137 irreversible, benzp[a)pyrene metabolites to liver microsome proteins -binding protein synthesis, effect of 1,24(R),25-trihydroxycholecalci- (rat), 18, 529 ferol (rat), 17, 362 neurotensin Ca2 to brain synaptic membranes (rat), 18, 11 peripheral site ligand activation of acetylcholinesterase activity to colon carcinoma cell line (HT 29) (human), 18, 11 (electric eel), 18, 33 to extraneural and neural receptors (human, rat), 18, 11 -regulated modulator protein interacting agents (chicken), 17, 66 opiate, phosphatidylserine and (rat), 17, 290 -stimulated protein kinase and ATPase (chicken), 17, 66 SUBJECT INDEX 619

-dependent activator protein, 17, 206 Chromaffin effect on opiate binding to brain membranes (rat), 17, 290 cells, cultured: secretion from (bovine), 18, 606 fluxes in sarcoplasmic reticulum vesicles, effect of dibucaine (rabbit), granules 17, 61 function, chemiosmotic mechanisms: effects of bretylium, guaneth- in histamine-induced glycogenolysis in brain (mouse), 17, 301 idine and N,N-diisopropyl-N’-isoamyl-N’-diethylaminoethylu- homeost,asis, alteration by taurine (rat), 17, 295 rea (P-286), 18, 606 mobilization, bone: effect of 1,24(R),25-trihydroxycholecalciferol membrane, W electrochemical gradient across, 18, 606 (rat), 17, 362 Cleavage potassium release mediated by, 18, 356 reductive glycosidic, anthracycline antibiotics, 17, 95 uptake, islet cells: effect of quinine and ionophores (rat), 18, 243 Computer CaIInOdUIin modeling, ligand binding to $-adrenergic receptor, 17, 14 activation of erythrocyte (Ca2 + Mgi-adenosinetriphosphatase, PROPHET studies, digitalis analogs, 17, 43 18, 253 Conformation interacting agents, myosin phosphorylation inhibition (chicken), 17, analysis, PCILO method: N-(fl-acetoxyethyl)pyridinium ion, corn- 66 parisons with acetylcholine, 18, 331 Calorimetry behavior by NMR, acyicholine analogs, 18, 20 differential scanning, myocardial membranes (ground squirrel), 18, change, agonist induced, 18, 362 476 requirements for interaction with central dopamine receptor, 17, 38 Carbon tetrachloride tertiary and quaternary, (Na + K)-activated adenosinetriphospha- -initiated lipid peroxidation (rat), 17, 408 tase: ouabain-induced changes, 18, 53 metabolism, liver microsomes and reconstituted monooxygenase sys- Cordycepin tems: relationship to lipid peroxidation (rabbit, rat), 18, 553 and rnethylation of nuclear RNA (cell culture), 18, 483 Carcinogen Crosslinking N-hydroxy-2-acetyla.minofluorene, activation by cumene hydroper- adenosinetriphosphatase (Na + Ki, effects of ouabain, 18, 53 oxide-hematin, 17, 233 Cross-tolerance Carcinogen-DNA lack of, on multiple opiate receptors in vas deferens (mouse), 18, 395 adducts, radioimmunoassay, 18, 581 Cryptopleurine Carcinoma cross-resistance studies, 18, 136 colon, cell line (H 29): neurotensin binding (human), 18, 11 Crystallography Cardiac glycosides /3-adrenergic drugs, 17, 339 radioreceptor assay, and progesterone derivatives, 18, 402 Cumene hydroperoxide-hematin Cardioactive drug activation of N-hydroxy-2-acetylaminofluorene, 17, 233 AR-L 57 [6-(2,4-dimethoxyphenyl)-imidazo-(4,5-$)-pyridine], inhibi- Cumene hydroperoxyl radical tion of sodium pump in axons (squid), 17, 350 spin trapping, 17, 233 Carrier Currents allosteric, for transport: serotonin, low concentrations, 18, 447 end-plate, see End-plate sites, specific: pinealocyte membranes (bovine), 18, 438 time- and voltage-dependent: effects of piperocaine on ion channel of Catecholamine acetylcholine receptor (electric ray), 17, 283 secretion, effects of N,N-diisopropyl-N’-isoamyl-N’-diethylamino- Cyanofenphos ethylurea (P-286), 18, 606 effect on fast axoplasmic transport (rat), 17, 56 tachyphylaxis to (BHK cells), 18, 370 Cyclic AMP, see Adenosine 3’,5’-monophosphate Cell Cyclic GMP, see Guanosine 3’,S’-monophosphate -free system, trifluorothymidine incorporation into thymus DNA: no Cyclic nucleotide chain termination (bovine), 18, 148 derivatives, cytotoxic effects in hepatoma cells (rat), 18, 65 Central nervous system Cyclic nucleotide phosphodiesterase muscarinic sites, effect of temperature (frog), 17, 141 activation by gangliosides, 17, 206 Cerebrospinal fluid activity, fibroblast: inhibition by xanthines (cell culture), 18, 57 choroid plexus, receptors (cat), 18, 199 rat Cerebrum, see Brain cerebral cortex, 17, 206 Chemotherapy diaphragm, 17, 73 carrier-bound methotrexate, interaction with L1210 cells (mouse), Cycloheximide 17, 382 effect on response of BHK cells to epinephrine, 18, 370 Chloramphemcol Cyproterone acetate inactivation of cytochrome P-450 (rat), 17, 427 effects on nuclear protein phosphokinases and phosphatases of yen- Chlorinated aromatic hydrocarbon tral prostate (rat), 17, 212 toxicity, and Ah locus (mouse), 17, 86 Cytidine 5’-diphosphate Chiormadinone acetate reduction by ribonucleotide reductase, kinetics, 18, 507 and digitalis receptor binding, 18, 402 Cytochrome P.450 1-Chloro-2,4-dinitrobenzene -dependent monooxygenase system, carbon tetrachloride metabolism substrate for liver glutathione transferase (mouse), 18, 559 in (rabbit), 18, 553 Cholinergic receptor destruction by olefins, 18, 602 human erythrocyte membrane, 18, 28 development, neonatal imprinting and (rat), 18, 543 muscarinic, desensitization, 18, 356 interaction with epoxides, 18, 128 rat parotid acinar cells, 18, 356 liver Cholinesterase heme turnover (rat), 17, 395 inhibition with diisopropylfluorophosphate (rat), 17, 24 inactivation by chloramphenicol (rat), 17, 427 Choroid plexus microsomes, destruction by olefins (rat), 18, 128 8-adrenergic-sensitive adenylate cyclase, properties and cellular lo- microsomes, kidney and lung: induction by 2,3,7,8-tetrachlorodi- calization (cat), 18, 199 benzo-p-dioxin (rabbit), 18, 565 620 SUBJECT INDEX

nucleolus, liver: location (rat), 18, 550 K, values, for lipophilic diaminopyrimidine antifolates in vitro (hu- nucleus, liver (hamster), 18, 151 man, mouse), 18, 521 transpiacental induction (rabbit), 17, 218 target enzyme, methotrexate (hepatoma cells), 17, 105 two forms in lung microsomes quantitation by substrate specificity 1,25-Dihydroxycholecalciferol (rabbit), 17, 415 comparison with 24(R),25-dihydroxycholecalciferol (rat), 17, 362 Cytosol 24(R),25-Dihydroxycholecalciferol prostate gland, inhibition of androgen receptors by divalent metal comparison with 1,25-dihydroxycholecalciferol (rat), 17, 362 ions (mouse), 17, 156 Diisopropylfluorophosphate Cytotoxicity cholinesterase inhibition (rat), 17, 24 methotrexate (hepatoma cells), 17, 105 N,N-Diisopropyl-N’-isoamyl-N’-diethylaminoethylurea (P.286) 8-substituted cyclic nucleotide derivatives, in hepatoma cells (rat), effects on chromaffin granule function 18, 606 18,65 6-(2,4-Dimethoxyphenyl)-imidazo-(4,5-$)-pyridine inhibition of sodium pump in axons (squid), 17,350 7,12.Dimethylbenz[aanthracene D metabolism (rabbit), 17, 225 Decamethonium Dinitrate receptor saturation, 18, 413 absence offormation during nitroglycerin-induced relaxation of blood 2’-Deoxyadenosine vessels (dog), 18, 112 and methylation of nuclear RNA (cell culture), 18, 483 2,3-Dinitrofluorobenzene 3’-Deoxyadenosine, see Cordycepin delayed hypersensitivity, suppression by 1-thiocarbamoyl-2-imida- Deoxycholate zolidinone (mouse), 18, 313 dissociation of[H]ouabain-Na,K-adenosinetriphosphatase complex, Diphenylhydantoin, see Phenytoin 18, 259 Dipyridamole Deoxyguanosine C-8 inhibition of mtrobenzylthioinosine binding and uridine transport, acetylated and deacetylated, adducts of N-acetoxy-2-acetylaminoflu- 18,40 orene, 18, 581 DNA Deoxyuridine triphosphate nucleotidohydrolase covalently closed circular, interaction with anthracyclines (phage), role in 5-fluorodeoxyuridine metabolism in tumor cells (human), 18, 17, 100 513 damage, from antitumor drugs (virus), 17, 388 Deoxyuridylate -dependent RNA polymerase, effect of6-mercaptopurine ribonucleo- pool size, effects of methotrexate and thymidine (cell culture), 18, tides, 18, 503 281 -directed cell-free synthesis of ,6-galactosidase, 18, 497 Dependence repair, effect of macromomycin-I (HeLa cells), 18, 491 lack of, multiple opiate receptors in vas deferens (mouse), 18, 395 replication, inhibition by macromycin-I (HeLa cells), 18, 491 Desbromoleptophos thymus, incorporation of trifluorothymidine in a cell-free system: no effect on fast axoplasmic transport (rat), 17, 56 chain termination (bovine), 18, 148 Desensitization DNA glycosylase ,8-adrenergic receptor, 18, 348 5-fluorouracil-containing DNA, tumor cells (human), 18, 513 effect on antagonism of histamine response by phenoxybenzamine DNA polymerase-a (guinea pig), 17, 309 5-fluorodeoxyuridine triphosphate and deoxyuridine triphosphate in- independent, -adrenergic receptor-regulated events, 18, 379 corporation, tumor cells (human), 18, 513 Desipramine inhibition by deoxyribonucleoside triphosphates (bovine), 17, 256 inhibition of norepinephrine uptake, comparison with bicycic inhib- regulation (bovine), 17, 256 itors, 17, 321 role in 5-fluorodeoxyuridine metabolism in tumor cells (human), 18, Diaminopyrimidine antifolates 513 lipophilic, biochemical pharmacology in vitro (human, mouse), 18, Dopamine 521 agonists, inhibition of tyrosine hydroxylase activity in striatal syn- Diaphragm aptosomes (rat), 18, 91 contraction, enhancement by xanthines (rat), 17, 73 antagonists, conformational requirements for activity, 17, 38 phosphodiesterase from (rat), 17, 73 enzymic conversion to norepinephrine, production of semidehydroas- Dibucaine corbate, 17, 421 effect on calcium fluxes (rabbit), 17, 61 Dopamine /1-hydroxylase, see Dopamine $-monooxygenase Dibutyryl cyclic GMP Dopamine fJ-monooxygenase interaction with pancreozymin (rat), 17, 268 coupling of semidehydroascorbate reductase to, 17, 421 Dopamine receptor analogs, structure-activity studies, 17, 43 bovine parathyroid cell, 18, 335 Digitalis receptor plasma membrane, presynaptic: regulation of tyrosine hydroxylase binding by progesterone derivatives, 18, 402 activity, 18, 91 dog heart, 18, 402 rat striatum, 18, 91 Digitoxigenin glucoside Dose-response inhibition of Na,K-adenosinetriphosphatase, 17,43 curve to histamine produced by phenoxybenzamine (guinea pig), 17, Dihydro-5-azacytidine 309 effects on nuclear RNA (leukemia cells), 17, 250 Drug Dihydrofolate binding to pool size, effects of methotrexate and thymidine (cell culture), 18, albumin fragments, 18, 224 281 serum albumin (human), 18, 157, 237, 421 Dihydrofolate reductase inhibition of iodohydroxybenzylpindolol binding (rat), 18,341 effect of lipophilic diaminopyrimidine antifolates in vitro (human, interacting, moduIator myosin phosphorylation inhibition (chicken), mouse), 18, 521 17, 66 SUBJECT INDEX 621

E membrane Ca2 pump adenosinetriphosphatase, effects of calmodulin and Electric eel phenothiazines (human), 18, 253 Electrophorus electricus cholinergic receptors (human), 18,28 acetylcholinesterase from, modulation ofactivity by peripheral site Erythromycin ligands, 18,33 inhibition of propranolol binding, 17, 187 electroplaque, pharmacological properties of acyl analogs of ace- Eseroline tyicholine, 18, 20 and morphine, quantum chemical study, 18, 461 Electric organ, see Electric ray Estrogen Electric potential interaction with estrogen receptor, 18, 406 eseroline and morphine, 18, 461 and metabolites, receptor bound in nucleus ofisolated liver cell (rat), Electric ray 18, 215 Torpedo californica: electroplax, ion exchange at acetylcholine re- Estrogen receptor ceptor, 18, 413 nuclear translocation in vitro, male, 17, 31 Torpedo ocellata, electric organ rat effect of piperocaine, 17, 283 liver parenchymal cell, male, 17, 31 membranes, effect of phencycidine, 18, 159 uterus, 18, 406 membranes, nereistoxin interaction with acetylcholine receptor, thermal stability when complexed with estrogens or antiestrogens, 17, 172 18, 406 receptors, effect of phencycidine, 18, 167 trypsin proteolysis, 18, 406 Electron paramagnetic resonance Ethanol autoxidation of 6-aminodopamine, 18,594 -induced fluidization of brain lipid bilayers (mouse), 17, 52 lipid-protein interactions in monoamine oxidase, 17, 192 tolerance, reversibility, and cross-tolerance (mouse), 17, 52 total lipid extract from myocardial membranes (ground squirrel), 18, Ethanolamine 476 derivatives, metabolites: from reduction ofmetronidazole by xanthine Electron spin resonance, see Electron paramagnetic resonance oxidase, 18, 105 Electrophoresis metabolite, from reduction of metronidazole by xanthine oxidase, 18, gel, two-dimensional: phosphoproteins (glioma cells), 18, 427 105 polyacrylamide gel, monoamine oxidases A and B (human, rat), 17, Ethoxycoumarin 199 metabolism, cytochrome P-450 isozymes (rabbit), 17, 218 Electroplaque, see Electric eel Ethylene Electrostatic potential, see Electric potential destruction of cytochrome P450, 18, 128, 602 Electrovalence 4-Ethyl-1-hexene changes of acetylcholine receptor, 18, 413 destruction of cytochrome P450, 18, 602 Emetine N-Ethylmaleimide cross-resistance studies, 18, 136 inactivation of $-adrenergic receptors, 17, 163 End-plate Ethylnitrosourea current inhibition of DNA function, 18, 497 acceleration of decay time by phencycidine, 18, 167 miniature, production in response to anatoxin-a, 18, 384 F peak amplitude depressed, 17, 172 Energy Fat cells interaction, with water eseroline and morphine, 18, 461 glycogen synthase activity and phosphatidylinositol labeling, modu- Enzyme lation ofeffect ofadrenergic amines by hypothyroidism (rat), 18, deficiency disease: L-gulonolactone oxidase in scurvy (guinea pig), 72 18, 326 membranes, $-adrenergic receptors: effects of thyroid status, 18, 193 histamine metabolizing, inhibition by lipid-soluble anticancer folate metabolism, effect of adrenergic action in hypothyroidism (rat), 18, antagonists, 18, 100 72 replacement therapy, 18, 326 Fibroblasts EPBP cyclic AMP escape and cyclic nucleotide phosphodiesterase activities, effect on fast axoplasmic transport (rat), 17, 56 inhibition by xanthines (cell culture), 18, 57 Epidermal growth factor receptor kidney, baby (BHK cells), loss and restoration of sensitivity to action of derivatives, 17, 314 epinephrine (hamster), 18, 370 Epidermis transformed, lung: puromycin aminonucleoside inhibition of RNA strips, adenosine-induced alterations in adenosine 3’,5’-monophos- synthesis (human), 17, 262 phate: effect of psoriasis (human, mouse), 18,49 Field desorption mass spectrometry Epinephrine green porphyrins, liver (rat), 18, 602 loss and restoration of sensitivity to (BHK cells), 18, 370 Flavin-adenine dinucleotide monooxygenase EPN hamster liver nucleus, 18, 588 effect on fast axoplasmic transport (rat), 17, 56 Fluorescent antibody staining Epoxide liver nuclei, location of mixed function amine oxidase (hamster), 18, interaction with cytochrome P450,18,128 151 Epoxide hydrolase 5-Fluorodeoxyuridine liver nucleoli (rat), 18, 550 metabolism in tumor cells (human), 18, 513 Erythrocytes 5-Fluorouracil f-adrenergic receptor effect on inactivation by N-ethylmaleimide (turkey), 17, 163 nuclear RNA synthesis and methylation (leukemia cells), 17, 245 internalization and receptor subsensitivity (frog), 18, 348 RNA synthesis, 17, 279 (turkey), comparison with $, and $2 receptors (mammal), 17, 1 incorporation into 5 S and 4 S RNA (leukemia cells), 17, 245 622 SUBJECT INDEX

5-Fluorouridine 5’-triphosphate myocardial membranes, changes in fluidity during hibernation effect on RNA transcribed in nuclei in vitro, 17, 279 (ground squirrel), 18, 476 Flurbiprofen [3H]ouabain-Na,K-adenosinetriphosphatase complex, dissociation binding sites on serum albumin (human), 18, 421 during enzyme isolation (rabbit), 18, 259 Flutamide particulate fraction, digitalis receptor: progesterone derivatives that effects on nuclear protein phosphokinases and phosphatases of yen- bind to (dog), 18, 402 tral prostate (rat), 17, 212 sarcolemma, taurine binding to (rat), 17, 295 Folate HeLa S3 cells antagonists, effect on histamine metabolism, 18, 100 DNA replication, inhibition by macromomycin-I, 18, 491 -independent site of action, lipophilic diaminopyrimidine antifolates Heme in vitro (human, mouse), 18, 521 prosthetic, N-alkylation of, 18, 602 Formycin B Hepatocytes, see Liver evaluation, 18, 287 Hepatoma cells cytotoxic effects of 8-substituted cyclic nucleotide derivatives (rat), G 18, 65 $-Galactosidase methotrexate toxicity, 17, 105 DNA-directed cell-free synthesis in vitro (phage), 18, 497 monoamine oxidases A and B, electrophoresis (rat), 17, 199 Gallamine treatment with methotrexate, modulation of toxicity by thymidine, peripheral site ligand, modulation of acetylcholinesterase activity 18, 281 (electric eel), 18, 33 Hibernation Gangliosides changes in fluidity ofmyocardial membrane during (ground squirrel), brain, activation of cyclic nucleotide phosphodiesterase, 17, 206 18, 476 Gastric acid High pressure liquid chromatography secretion, inhibition by urogastrone derivatives, 17, 314 separation of metabolites of N-methylcarbazole, 17, 128 Genetics Histamine aflatoxins B, and B2, metabolism (mouse, inbred strains), 18, 296 3H labeled, high-affinity binding sites in brain (rat), 18, 1 Glioma cells metabolism, alteration by antifolates, 18, 100 C-6, intact: norepinephrine-dependent protein phosphorylation, 18, response, antagonism by phenoxybenzamine: effect of desensitization 427 (guinea pig), 17, 309 monoamine oxidases, electrophoresis (rat), 17, 199 Histamine receptor Glutathione transferase H,, mouse brain slices, 17, 301 activity, liver: induction by polycyclic aromatic compounds, not Human associated with Ah locus (mouse), 18, 559 cells in vitro, biochemical pharmacology of lipophilic diaminopy- Glycine rimidine antifolates, 18, 521 incorporation into cytochrome P-450 heme (rat), 17, 395 erythrocyte membrane cholinergic receptors, characterization, 18,28 3H-Glycogen lymphoblasts, purine nucleoside phosphorylase, 18, 287 hydrolysis, elicited by histamine (mouse), 17, 301 serum albumin Glycogen synthase binding sites for nonsteroidal anti-inflammatory drugs, 18, 421 activity, fat cells: modulation of effect of adrenergic amines in hypo- drug binding, interaction between phenytoin and valproate, 18, thyroidism (rat), 18, 72 237 Guanethidine specificity of drug binding sites, 18, 157 effects on chromaffin granule function, 18, 606 tumor cells, metabolism of 5-fluorodeoxyuridine, 18, 513 Guanine nucleotides Hydantoins and high and low affinity states of $-adrenergic receptor, 17, 14 and metabolites, in metaphase arrest and microtubular polymeriza- and receptor affinity, 18, 193 tion, 17, 275 Guanosine 3’,5’-monophosphate N-Hydroxyacetaminophen levels in diaphragm (rat), 17, 73 arylating intermediate from, 18, 536 Guanosine 5’-triphosphate mutagemcity (bacteria), 18, 117 -dependent process, adenylate cyclase inhibition, 18, 598 N-Hydroxy-2-acetylaminofluorene effects on thermodynamics of agonist binding, 18, 341 activation by cumene hydroperoxide-hematin, 17, 233 and receptor affinity, 18, 193 N-Hydroxyacetylarylamine Guanyl-5’-yl-imidodiphosphate mutagenicity, mechanism (bacteria), 18, 117 and receptor affinity, 18, 193 6-Hydroxydopamine L-Gulonolactone oxidase autoxidation, 18, 594 implantation in dialysis bag, in ascorbic acid synthesis (guinea pig), treatment, effect on heart autonomic receptors (rat), 18, 185 18, 326 8-Hydroxyethylaminoadenosine 3’,S’-monophosphate H cytotoxic effects in cultured hepatoma cells (rat), 18, 65 N-Hydroxymethylcarbazole Heart atrium: adenylate cyclase system, effect of hypothyroidism (rat), 17, formation in liver microsomes (rabbit), 17, 128 180 1-Hydroxy-N-methylcarbazole autonomic receptors, alterations after 6-hydroxydopamine treatment formation in liver microsomes (rabbit), 17, 128 (rat), 18, 185 2-Hydroxy-N-methylcarbazole cells, fi’ and $2 adhenergic receptors responsible for cyclic AMP formation in liver microsomes (rabbit), 17, 128 accumulation (rat), 17, 8 3-Hydroxy-N-methylcarbazole developing, regulation of omithine decarboxylase activity: effect of formation in liver microsomes (rabbit), 17, 128 hyperthyroidism (rat), 18, 247 N-Hydroxyphenacetin effect of iodohydroxyben.zylpindolol (cat), 17, 328 metabolic activation by liver and kidney fractions (hamster, human, I-iodohydroxybenzylpindolol binding (rat), 17, 1 mouse, rat), 18, 117 SUBJECT INDEX 623

8-Hydroxyquinoline Ion aromatic chelator, antimalarial activity, 18, 320 exchange between agonists and inorganic ions at acetylcholine recep- 5-Hydroxytryptamine, see Serotonin tor, 18, 413 Hypertension transport, magnesium, 18, 379 effect on biochemistry of vascular smooth muscle plasma membrane Ionic channel (rat), 17, 137 agonist activation Hyperthyroidism by anatoxin-a, 18, 384 effects on inhibition by phencycidine, 18, 159 fat cell $-adrenergic receptors (rat), 18, 193 inhibition, 17, 283 ornithine decarboxylase activity in developing heart (rat), 18, 247 reaction with open and closed, 18, 167 Hypothalamus time course unchanged, 17, 172 synaptosomes: norepinephrine uptake, effect of phthalane and lonophore thiophthalane inhibitors (rat), 17, 321 X537A, and quinine: effect on calcium uptake in islet cells (rat), 18, Hypothyroidism 243 effects on Iron cardiac adenylate cyclase system (rat), 17, 180 -initiated lipid peroxidation (rat), 17, 400 fat cell fl-adrenergic receptors (rat), 18, 193 Isoprenaline modulation of effect of adrenergic amines on phosphatidylinositol effect on cardiac cAMP in hypothyroidism (rat), 17, 180 labeling and glycogen synthase activity of fat cells (rat), 18, 72 Isoproterenol -sensitive adenylate cyclase in prostate, effects of androgens (rat), I 18, 45 Ibuprofen J binding sites on serum albumin (human), 18, 421 Junction, see Neuromuscular junction Imidazopyridine derivative, inhibition of sodium pump in axons (squid), 17, 350 K Imidazo-(4,5-$)-pyridine 6-(2,4-dimethoxyphenyl)-, sodium pump inhibition by (squid), 17, Kidney 350 fibrobasts (BHK cells), loss and restoration of sensitivity to epineph- Immunochemistry tine (hamster), 18, 370 N-acetyltransferases (rabbit), 17, 367 fractions, metabolic activation of N-hydroxyphenacetin (hamster, Immunohistochemistry human, mouse, rat), 18, 117 localization and distribution of NADPH-cytochrome c (P-450) re- microsomes, cytochrome P450: induction by 2,3,7,8-tetrachiorodi- ductase in liver (rat), 17, 374 benzo-p-dioxin (rabbit), 18, 565 Immunological properties L pancreozymin-gastrmn family of peptides, interference by dibutyryl cyclic GMP (rat), 17,268 Leptophos Imprinting effect on fast axoplasmic transport (rat), 17, 56 neonatal, and development of cytochrome P450 (rat), 18, 543 Leukemia cells Inhibition L1210 adenylate cyclase, by GTP-dependent process, 18, 598 adenosine and RNA methylation, 18, 483 cholinesterase, with diisopropylfluorophosphate (rat), 17, 24 growth in culture, alterations in methotrexate transport during [3H]Inositol (mouse), 18, 274 incorporation into salivary gland lipids, effects of substance P (rat), interaction of carrier-bound rnethotrexate with (mouse), 17, 382 18, 78 nuclear ribosomal RNA and poly(A) RNA synthesis, effect of 5- Insulin azacytidine and dihydro-5-azacytidine, 17, 111 release, islet cells: effect of quinine (rat), 18, 243 nuclear RNA, comparative effects of 5-azacytidine and dihydro-5- Interaction energy azacytidine, 17, 250 with water, eseroline and morphine, 18, 461 nuclear RNA synthesis and methylation in vitro, effect of 5-fluo- Interferon rouracil, 17, 245 -inducing agents Lidoflazine effect on cytochrome P-450 heme turnover (rat), 17, 395 inhibition of mtrobenzylthioinosine binding and uridine transport, polyriboinosinic acid.polyribocytidylic acid and tiorone, 17, 395 18, 40 Internalization Ligand $-adrenergic receptor recognition sites, 18, 348 anionic Intestine binding to albumin fragments, 18, 224 calcium-binding protein synthesis, effect of 1,24(R),25-trihydroxy- competitive binding to albumin, quantitative aspects, 18, 230 cholecalciferol (rat), 17, 362 binding to fl-adrenergic receptor, computer modeling, 17, 14 colon, carcinoma cell line (H 29): neurotensin binding (human), 18, peripheral site, modulation of acetylcholinesterase activity by (elec- 11 tric eel), 18, 33 ileum Ligand-metal muscarinic receptors (guinea pig), 18, 179 complex, association with antimalarial activity of aromatic chelators, smooth muscle: blockade of histamine response by phenoxybenz- 18,320 amine, effect of desensitization (guinea pig), 17, 309 Lipases as probes, monoamine oxidases A and B in intact brain mitochondria i25j binding (rat), 18, 267 rat heart, 17, 1 Lipid turkey erythrocyte, 17, 1 bilayers partial agonist, cardiac tissues (cat), 17, 328 brain, chronic ethanol effect (mouse), 17, 52 preparation, purification, and localization of iodine (cat), 17, 328 perturbation by general anesthetics, 18, 84 624 SUBJECT INDEX

peroxidation, microsomes Lymphoma carbon tetrachloride metabolism and (rabbit, rat), 18, 553 S49 cells initiation by carbon tetrachioride (rat), 17, 408 inactivation of $-adrenergic receptors by N-ethyhnaleimide, 18, initiation by iron (rat), 17, 400 362 -soluble anticancer folate antagonists, effect on histamine met,abo- independent desensitization offl-receptor-regulated events, 18, 379 lism, 18, 100 Lysolecithin Lipid-protein activation of cyclic nucleotide phosphodiesterase, 17, 206 interactions in monoamine oxidases in brain (rat), 17, 192; 18, 267 Lysosomes Lithium bromide hepatocytes, effects of amines on protein degradation (rat), 18, 468 dissociation of[3H]ouabain-Na,K-adenosinetriphosphatase complex, Lysosomotropism 18, 259 arnines, in hepatocytes (rat), 18,468 Liver M N-acetyltransferases, immunochemical studies (rabbit), 17, 367 cells, embryo: porphyrin-inducing and membrane fluidizing actions Macromomycin of steroids (chicken), 18, 144 DNA damage after treatment with (virus), 17, 388 cytochrome P450 Macromomycin-I heme turnover, effect of interferon inducing agents (rat), 17,395 inhibition of DNA replication (HeLa cells), 18, 491 inactivation by chioramphenicol (rat), 17, 427 Magnesium fractions, metabolic activation of N-hydroxyphenacetin (hamster, agonist exchange at receptor, 18, 413 human, mouse, rat), 18, 117 ion transport (lymphoma cells), 18, 379 green porphyrins (rat), 18, 602 Me+, peripheral site ligand activation ofacetylcholinesterase activity hepatocytes, isolated: protein degradation and synthesis, effects of (electric eel), 18, 33 lysosomotropic amines (rat), 18,468 MAIQ.1, see 4-Methyl-5-amino-1-formylisoquinoline thiosemicarba- hepatoma, see Hepatoma cells zone isOlated nuclei, effect of 5-fluorouridine 5’-triphosphate on RNA Malaria transcribed in vitro (rat), 17, 279 parasite glycolysis, inhibition by 8-hydroxyquinoline, 18, 320 lobule, distribution of NADPH-cytochrome c (P450) reductase: ef- Maleimidobenzyltrimethylammonium fects of phenobarbital, pregnenolone-16a-carbomtrile, and 3- receptor alkylation with (rat), 17, 149 methylcholanthrene pretreatments (rat), 18, 304 Marine worm microsomes Lumbriconereis heteropoda: nereistoxin from, interaction with ace- aerobic, reductive metabolism of metronidazole and romdazole tyicholine receptor-ionic channel complex, 17, 172 (rat), 17, 239 Membrane carbon tetrachloride metabolism and lipid peroxidation (rabbit, cholinergic receptors, erythrocyte (human), 18,28 rat), 18, 553 excitable, effects of 9-tetrahydrocannabinol (frog), 17, 344 cytochrome P450, destruction by olefins in vitro (rat), 18, 128 fluidity cytochrome P450, effect of neonatal imprinting (rat), 18, 543 adaptation to ethanol, 17, 52 cytochrome P450 forms induced by phenobarbital (rabbit), 17, changes during hibernation (ground squirrel), 18, 476 218 fluidization, embryo liver cells: association with porphyrin induction lipid peroxidation, role of iron and NADPH (rat), 17, 400 (chicken), 18, 144 lipid peroxidation, stimulation by carbon tetrachioride (rat), 17, neural, muscarinic receptor effect of temperature (frog), 17, 141 408 physical state, effect on phosphatidylserine requirement for opiate N-methylcarbazole metabolism (mouse, rabbit, rat), 17, 118; (rab- binding (rat), 17, 290 bit), 17, 128 pinealocyte, measurement of serotonin binding (bovine), 18, 438 proteins, binding of benzo[a]pyrene metabolites (rat), 18,529 plasma, vascular smooth muscle: effect of hypertension on biochem- NADPH-cytochrome c (P450) reductase distribution (rat), 17, 374 istry (rat), 17, 137 nuclei, superoxide production (hamster), 18, 588 3H-Mepyramine nucleolus, cytochrome P-450 location (rat), 18, 550 binding, brain (mouse), 17,301 parenchymal cell 6-Mercaptopurine ribonucleoside 5’-triphosphate male, in vitro nuclear translocation of estrogen receptor (rat), 17, inhibition of RNA polymerase, 18, 503 31 6-Mercaptopurine ribonucleotides nucleus, receptor-bound estrogens and metabolites (rat), 18, 215 effect on DNA-dependent RNA polymerase activity, 18, 503 Locus 2-Mercaptopyridine-N-oxide Ah aromatic chelator, antimalarial activity, 18, 320 glutathione transferase not associated with (mouse), 18, 559 Mescaline and toxicity of 2,3,7,8-tetrahydrodibenzo-p-dioxin (mouse), 17,86 analogs Lung molecular potentials, similar to 5-hydroxytryptamine, 18, 455 cells, f1 and $2 adrenergic receptors responsible for cyclic AMP 3 and 4 ring positions, 18, 455 accumulation (rat), 17, 8 Metabolic activation fibroblasts, transformed: puromycin aminonucleoside inhibition of N-hydroxyphenacetin, by liver and kidney fractions (hamster, hu- RNA synthesis (human), 17, 262 man, mouse, rat), 18, 117 microsomes Metabolism cytochrome P450: induction by 2,3,7,8-tetrachlorodibenzo-p- 5-fluorodeoxyuridine, in tumor cells (human), 18, 513 dioxin (rabbit), 18, 565 Metabolites two forms ofcytochrome P450: quantitation by substrate specific- benzo[a]pyrene, binding to liver microsome proteins (rat), 18, 529 ity (rabbit), 17, 415 Metal Lymphoblasts ions, divalent: actions in prostate gland (mouse), 17, 156 purine nucleoside phosphorylase deficiency (human), 18,287 Metalloprotein oxidases Lymphocytes inhibition, and antimalarial activity of aromatic chelators, 18, 320 culture, potency of hydantoins in metaphase arrest (human), 17, 275 Metaphilic effect SUBJECT INDEX 625

in desensitization effect on blockade of histamine response by phe- N-methylcarbazole metabolism, 17, 118, 128 noxybenzamine (guinea pig), 17, 309 Molecular mechanics S-Methionine digitalis conformation, 17, 43 labeling, proteins (glioma cells), 18, 427 Molecular potentials Methotrexate phenethylamines, 18,455 carrier bound, interactions with L1210 cells (mouse), 17, 382 Monoamine oxidase comparison with lipophilic diaminopyrimidine antifolates in vitro A and B (human, mouse), 18, 521 human platelets, 17, 199 cytotoxicity (hepatoma cells), 17, 105 3H-pargylene labeled, electrophoresis, 17, 199 polyglutamate forms, cytotoxicity (hepatoma cells), 17, 105 rat glioma cells and hepatoma cells, 17, 199 toxicity, modulation by thymidine (cell culture), 18, 281 lipid-protein interactions, 17, 192; 18, 267 transport, growth phase dependence (leukemia cell culture), 18, 274 rat brain mitochondria in situ, 17, 192; 18, 267 4-Methyl-5-amino-1-formylisoquinoline thiosemicarbazone Monooxygenase ferrous chelate, effects on ribonucleotide reductase (rat), 18, 507 activity, microsomes: induction by 1,4-bis[2-(3,5-dichloropyridyl- N-Methylcarbazole oxy)]benzene (mouse), 18, 571 metabolism, in liver microsomes (mouse, rabbit, rat), 17, 118; (rabbit), brain, heme-mediated stimulation (rabbit), 17, 225 17, 128 systems, reconstituted: carbon tetrachloride metabolism, 18, 553 3-Methyicholanthrene Morphine effects on metabolism ofaflatoxins B, and B (mouse, inbred strains), and eseroline, quantum chemical study, 18, 461 18, 296 Mouse induction of glutathione transferase (mouse), 18, 559 inbred strains, genetics of aflatOxins B, and B metabolism, 18, 296 pretreatment, effect on NADPH-cytochrome c (P.450) reductase Muscarinic cholinergic receptor distribution in liver lobule (rat), 18, 304 frog central nervous system neural membranes, 17, 141 1-Methyl-3-isobutylxanthine Muscarinic receptor and analogs, inhibition of fibroblast cyclic AMP escape and cyclic guinea pig ileum, 18, 179 nucleotide phosphodiesterase activities (cell culture), 18, 57 inhibition by phencycidine, 18, 179 Methylnitrosourea rat brain, 17, 24; 18, 179 alkylation and carbamoylation of DNA by, 18, 497 Muscarone inhibition of DNA function, 18, 497 receptor saturation, 18, 413 N-Methyl protoporphyrin IX Muscle dimethyl ester, in destruction ofcytochrome P450 by olefins, 18,602 sartorius, effect of piperocaine on endplate current (frog), 17, 283 Metronidazole skeletal metabolites from reduction by xanthine oxidase (rat), 18, 105 diaphragm, effect of xanthines: lack of relationship between phos- reductive metabolism (rat), 17, 239 phodiesterase inhibition and increased twitch tension (rat), 17, Microsomes 73 incubation, inhibition ofcovalent binding ofacetaminophen by ascor- fast, effect ofdibucaine on calcium fluxes in sarcoplasmic reticulum bate, 18, 536 vesicles (rabbit), 17, 61 induction of monooxygenase activity by 1,4-bis[2-(3,5-dichloropyri- neuromuscular junction, effects of phencycidine on electrical ex- dyloxy)]benzene (mouse), 18, 571 citability and chemosensitive properties (electric ray, frog, rat), liver 18, 159 aerobic, reductive metabolism of metronidazole and ronidazole synapses, effect of nereistoxin (frog, rat), 17, 172 (rat), 17, 239 smooth carbon tetrachioride metabolism and lipid peroxidation (rabbit, artery and vein, nitroglycerin-induced relaxation, mechanism rat), 18, 553 (dog), 18, 112 cytochrome P450 forms induced by phenobarbital (rabbit), 17, artery, plasma membrane: effect of hypertension on biochemistry 218 (rat), 17, 137 cytochrome P450, neonatal imprinting and testosterose hydrox- gizzard, myosin phosphorylation inhibition by modulator interact- ylation in reconstituted system (rat), 18,543 ing agents (chicken), 17, 66 lipid peroxidation, role of iron and4ADPH (rat), 17, 400 ileum, blockade of histamine response by phenoxybenzamine, ef- lipid peroxidation, stimulation by carbon tetrachloride (rat), 17, fect of desensitization (guinea pig), 17, 309 408 ileum, contraction: comparison of effects of phencycidine and N-methylcarbazole metabolism (mouse, rabbit, rat), 17, 118; (rab- phencycidine methiodide (guinea pig), 18, 179 bit), 17, 128 isolated, uterus: photoaffinity labeling of angiotensin II receptors proteins: binding of benzo[a]pyrene metabolites (rat), 18, 529 (rat), 18, 210 lung, two forms of cytochrome P.450: quantitation by substrate twitch, potentiation by phencycidine (frog), 18, 159 specificity (rabbit), 17, 415 Myeloblastosis Microtubules cells, RNA polymerase: effect of 6-mercaptopurmne ribonucleotides, polymerization, inhibition by hydantoins, 17, 275 18, 503 Mitochondria Myocardium brain, lipid-protein interactions in monoamine oxidases in situ (rat), adenosinetriphosphatase activity (ground squirrel), 18, 476 17, 192; 18, 267 membranes, changes in fluidity during hibernation (ground squirrel), Mitosis 18, 476 metaphase arrest, potency of hydantoins in, 17, 275 Myosin Mixed function oxidases smooth muscle, phosphorylation: inhibition by modulator interacting induction, inhibition, and species differences, 17, 118 agents (chicken), 17,66 liver microsomes (mouse, rabbit, rat), 17, 118; (rabbit), 17, 128 N nucleoli (rat), 18, 550 NADPH nucleus, location and specific activity (hamster), 18, 151 and iron, role in microsomal lipid peroxidation (rat), 17, 400 626 SUBJECT INDEX

NADPH-cytochrome c (P-450) reductase ‘H Fourier transform, structural identification of metabolites of N- immunohistochemical localization and distribution in liver (rat), 17, methylcarbazole, 17, 128 374; 18, 304 Nucleolus 18-Naphthoflavone liver, cytochrome P-450 location (rat), 18, 550 induction of glutathione transferase (mouse), 18, 559 mixed function oxidases (rat), 18, 550 Naproxen Nucleoside binding sites on serum albumin (human), 18, 421 transport, inhibition by dipyridamole and nitrobenzylthioinosine Neocarzinostatin (HeLa cells), 18, 40 DNA damage after treatment with (virus), 17, 388 Nucleus Nereistoxin liver from marine worm, effect on acetylcholine receptor-ionic channel, parenchymal cell, isolated: receptor-bound estrogens and metabo- 17, 172 lites (rat), 18, 215 Nerve superoxide production (hamster), 18, 588 axon, sodium pump, inhibition by AR-L 57 (squid), 17, 350 mixed function amine oxidase, liver: location and specific activity optic, effect of delayed neurotoxic organophosphorus esters (rat), 17, (hamster), 18, 151 56 translocation, in vitro: estrogen receptor in male (rat), 17, 31 Neuroleptic drugs conformational requirements for activity, 17, 38 0 effect on (Ca2 + Ma21-adenosinetriphosphatase activity, 18, 253 Neuromuscular junction Olefins activation by anatoxin-a (frog), 18, 384 destruction of cytochrome P-450 by, 18, 602 effects of i9-tetrahydrocannabinol (frog), 17, 344 Opiate skeletal muscle, effects of phencycidine on electrical excitability and binding, phosphatidylserine requirement for (rat), 17, 290 chemosensitive properties (electric ray, frog, rat), 18, 159 Opiate receptor Neuromuscular transmission mouse vas deferens, 18, 395 effects of i9-tetrahydrocannabinol (frog), 17, 344 multiple, lack of cross-tolerance, 18, 395 inhibition by phencycidine, 18, 159, 167 Optic nerve Neurotensin effect of delayed neurotoxic organophosphorus esters (rat), 17, 56 and analogs, binding to extraneural and neural receptors (human, Organophosphorus esters rat), 18, 11 effect on fast axoplasmic transport (rat), 17, 56 3H labeled: binding to brain synaptic membranes (rat), and colon Ornithine decarboxylase carcinoma cell line (HT 29) (human), 18, 11 activity, regulation in developing heart: effect of hyperthyroidism Neurotoxicity (rat), 18, 247 delayed, organophosphorus esters: inhibition of fast axoplasmic Ouabain transport (rat), 17, 56 -induced changes in tertiary and quaternary conformations of (Na Nicotinic receptor + K)-activated adenosinetriphosphatase, 18, 53 affinity reagents for, 17, 149 radioreceptor binding assay, 18, 402 desensitization by anatoxin-a, 18, 384 [3H]Ouabain-Na,K-adenosinetriphosphatase disulfides and sulfhydryls of, 17, 149 complex, dissociation during enzyme isolation, heart (rabbit), 18, 259 electric ray electric organ, 18, 167 frog neuromuscular junction, 18, 384 P rat brain, 17, 149 Niridazole P-286, see N,N-Diisopropyl-N’-isoamyl-N’-diethylaminoethylurea immunoregulatory metabolite: 1-thiocarbamoyl-2-imidazolidinone, Palmitic acid 18, 313 inhibition of propranolol binding, 17, 187 Nitrobenzylthioinosine Pancreas binding, inhibition by dipyridamole and lidoflazine, 18, 40 exocrine, plasma membranes: pancreozymin, interaction with dibu- inhibition of uridine transport (HeLa cells), 18, 40 tyryl cyclic GMP (rat), 17, 268 Nitroglycerin islets, isolated: effect ofquinine on insulin release and calcium uptake -induced relaxation of smooth muscle in blood vessels, mechanism (rat), 18, 243 (dog), 18, 112 Pancreozymin lack of metabolism by smooth muscle (dog), 18, 112 interaction with dibutyryl cyclic GMP (rat), 17, 268 and metabolites, smooth muscle of blood vessels (dog), 18, 112 Paraoxon Nitro group inhibition of mutagenicity, N-hydroxyphenacetin (bacteria), 18, 117 reduction, relation to biological actions of metronidazole, 18, 105 Parathion Nitroimidazole effect on fast axoplasmic transport (rat), 17, 56 anion free radical phantom intermediates (rat), 17, 239 Parathyroid Nitrosophenol cells, dispersed: characterization of dopamine receptors (bovine), 18, from N-hydroxyacetaminophen, 18, 536 335 Norepinephrine Parathyroid hormone concentration, 5 heart regions: effect of 6-hydroxydopamine treat- release, regulation (bovine), 18, 335 ment (rat), 18, 185 3H-Pargyline -dependent protein phosphorylation (glioma cells), 18, 427 -labeled monoamine oxidases A and B, electrophoresis, 17, 199 from enzymic conversion of dopamine, production of semidehydroas- Parotid corbate, 17, 421 acinar cells uptake: inhibition by phthalane and thiophthalane, comparison with a-adrenergic regulation of cholinergic responses (rat), 18, 356 desipramine, 17, 321 potassium release (rat), 18, 356 Nuclear magnetic resonance glands, lipids: incorporation of [3H]inositol, effects of substance P conformational behavior by, acylcholine analogs, 18, 20 (rat), 18, 78 SUBJECT INDEX 627

Partition coefficients Phthalane lipid/water, and antimalarial activity of aromatic chelators, 18, 320 inhibitors of norepinephrine uptake, 17, 321 PCILO Phytohemagglutin method, conformational analysis of N-(fl-acetoxyethyl)pyridinium stimulation of lymphocytes, potency of hydantoins in metaphase ion, 18, 331 arrest (human), 17, 275 perturbative configuration interaction usinglocalized orbital method, Pigments 17, 339 hepatic green, formation after olefin administration (rat), 18, 128, PCP, see Phencycidine 602 Pentobarbital Pinealocytes cross-tolerance with ethanol (mouse), 17, 52 isolation (bovine), 18, 438, 447 Perhydrohistrionicotoxin Piperocaine binding effects on to electric organ membranes (electric ray), 17, 283 acetylcholine receptor ion channel complex (electric ray), 17, 283 to electroplax membranes, effect of nereistoxin, 17, 172 endplate current, muscle (frog), 17, 283 inhibition by phencycidine, 18, 167 Platelets Persantine, see Dipyridamole blood: serotonin secretion, effect of extracellular pH (rat), 17, 356 pH monoamine oxidases, electrophoresis (human), 17, 199 extracellular, effect on control of blood platelet serotonin secretion Polyadenylic acid (rat), 17, 356 in RNA: synthesis, effect of 5-azacytidine and dihydro-5-azacytidine Phage, see Bacteriophage (leukemia cells), 17, 111 Phencycidine Polymerization effects on electrical excitability and chemosensitive properties of microtubules, inhibition by hydantoins, 17, 275 neuromuscular junction of skeletal muscle (electric ray, frog, Polyriboinosinic acid. polyribocytidylic acid rat), 18, 159 effect on cytochrome P-450 heme turnover (rat), 17, 395 inhibition of peak amplitude end-plate current, 18, 167 Porphyrin and phencycidine methiodide, comparison of interactions with mus- N-alkylated, 18, 602 carinic receptors, 18, 179 induction, association with membrane fluidization, 18, 144 Phencycidine methiodide Potassium and phencycidine, comparison ofinteractions with muscarmnic recep- channel blockade by phencycidine, 18, 159 tore, 18, 179 Potential Phenethylamines action, prolongation by phencyclidine, 18, 159 hallucinogenic potency, 18,455 molecular, phenethylamines, 18, 455 Phenobarbital Pregnenolone-16a-carbonitrile induction of cytochrome P.450 forms (rabbit), 17, 218 pretreatment, effect on NADPH-cytochrome c (P-450) reductase -like inducer of microsomal monooxygenase activity: 1,4-bis[2-(3,5- distribution in liver lobule (rat), 18, 304 dichloropyridyloxy)]benzene (mouse), 18, 571 Presynaptic regulation pretreatment, effect on NADPH-cytochrome c (P450) reductase tyrosine hydroxylase activity in striatal synaptosomes by dopamine distribution in liver lobule (rat), 18, 304 analogs (rat), 18, 91 Phenothiazines Progesterone inhibition of (Ca2 + Mgi-adenosinetriphosphatase, 18, 253 derivatives, and digitalis receptor binding: structure-activity relation- Phenoxybenzamine ships, 18,402 antagonism ofhistamine response by, effect ofdesensitization (guinea Progestins pig), 17, 309 digitalis receptor binding, 18,402 Phenylephrine PROPHET, see Computer effect on cardiac cAMP in hypothyroidism (rat), 17, 180 Propidium Phenytoin peripheral site ligand, modulation of acetylcholinesterase activity interaction with vaiproate, binding to serum albumin (human), 18, (electric eel), 18, 33 237 in metaphase arrest and microtubular polymerization, 17, 275 Propranolol perturbation of lipid bilayers, 18,84 binding, distribution between serum proteins (human), 17, 187 Pheochromocytoma Prostate clonal cell line, tyrosine hydroxylase (rat), 17, 79 gland, inhibition of androgen receptors by divalent metal ions Phosphatidylinositol (mouse), 17, 156 labeling, effect of adrenergic amines: modulation in hypothyroidism isoproterenol-sensitive adenylate cyclase system, effects of androgens (rat), 18, 72 (rat), 18, 45 turnover in salivary glands, effects of substance P (rat), 18, 78 ventral Phosphatidylserine nuclear protein phosphokinases and phosphatases, effects of an- requirement for opiate binding (rat), 17, 290 tiandrogens (rat), 17, 212 Phosphodiesterase phosphorylation of chromatin proteins, effects of antiandrogens cyclic nucleotide, see Cyclic nucleotide phosphodiesterase (rat), 17, 212 inhibition by xanthines (cell culture), 18, 57 Protein Phospholipase A2 activator, calcium-dependent, 17, 206 effect on opiate binding to brain membranes (rat), 17, 290 antitumor, antibiotic: macromycin-I, inhibition of DNA replication Phospholipids (HeLa cells), 18, 491 brain membranes, in opiate binding (rat), 17, 290 calcium Phosphorylation -binding, intestine: effect of 1,24(R),25-trihydroxycholecalciferol myosin, inhibition by modulator interacting agents (chicken), 17,66 (rat), 17, 362 Photoaffinity labeling -regulated modulator, interacting agents: myosin phosphorylation angiotensin H receptors, 18, 210 inhibition (chicken), 17, 66 628 SUBJECT INDEX

degradation in hepatocyte lysosomes, inhibition by amines (rat), 18, Regulation 468 presynaptic, tyrosine hydroxylase activity in striatal synaptosomes intermediate filament, phosphorylation of (glioma cells), 18, 427 by dopamine analogs (rat), 18, 91 microsomes, liver: binding of benzo[a]pyrene metabolites (rat), 18, Relaxation 529 nitroglycerin induced, isolated blood vessels: absence of metabolite phosphorylation formation (dog), 18, 112 in blood platelets, effect of extracellular pH (rat), 17, 356 1-$-D-Ribofuranosyl-1,2,4-trlazole-3-carboxalmdlne norepinephrine-dependent (glioma cells), 18, 427 inhibition of human lymphoblast purine nucleoside phosphorylase, serum, propranolol binding (human), 17, 187 18,287 synthesis Ribonucleoside-diphosphate reductase in hepatocytes, effects of amines (rat), 18, 468 from Novikoff tumor, effects of ferrous chelate of 4-methyl-S-amino- inhibitors, 18, 136 1-formylisoquinoline thiosemicarbazone (rat), 18, 507 Protein kinase Ribonucleotide reductase, see Ribonucbeoside-diphosphate reductase calcium stimulated, smooth muscle (chicken), 17, 66 RNA Protein phosphatase liver, transcribed in nuclei in vitro (rat), 17, 279 nucleus, ventral prostate: effects of antiandrogens (rat), 17, 212 methylation, effects of Protein phosphokinase 5-azacytidine and dihydro-5-azacytidine (leukemia cells), 17, 250 nucleus, ventral prostate: effects of antiandrogens (rat), 17, 212 5-fluorouracil (leukemia cells), 17, 245 Psoriasis nuclear epidermal stripe, effects on adenosine-induced alterations in adeno- comparative effects of 5-azacytidine and dihydro-5-azacytidine sine 3’,5’-monophosphate (human), 18, 49 (leukemia cells), 17, 250 Purine nucleoside phosphorylase methylation, effect of adenosine and cordycepin (cell culture), 18, inhibition, 18, 287 483 Puromycin aminonucleoside methylation, effect of5-azacytidine and dihydro-5-azacytidine (leu. inhibition of RNA synthesis, mechanism, 17, 262 kemia cells), 17, 111 metabolism (fibroblasts), 17, 262 polyadenylic acid-containing: synthesis in vitro, effect of 5-azacyti- dine and dihydro-5-azacytidine (leukemia cells), 17, 111 ribosomal: synthesis in vitro, effect of 5-azacytidine and dihydro-5- Q azacytidine (leukemia cells), 17, 111 QNB, see [3H]Quinucidinyl benzilate synthesis Quantal release effect of 5-fluorouracil (leukemia cells), 17, 245 effects of 9-tetrahydrocannabinol (frog), 17, 344 inhibition by puromycin aminonucleoside, mechanism of action Quantum chemistry (human), 17, 262 eseroline and morphine, 18, 461 RNA polymerase Quinine DNA dependent, inhibition by 6-mercaptopurine ribonucleotides effect on insulin release and calcium ionophoresis in islet cells (rat), (bacteria, chicken), 18, 503 18, 243 liver, isOlated nuclei (rat), 17, 279 [3H]Quinucidinyl benzilate Ronidazole binding to muscarinic receptors (rat), 17, 24 reductive metabolism (rat), 17, 239 dl-[3H]Quinucidinyl benzilate Rubidium binding ouabain-sensitive Rb influx into axon, inhibition by AR-L 57 erythrocyte membranes (human), 18,28 (squid), 17, 350 inhibition by phencycidine, 18, 179 S

Salivary glands R salivation and phosphatidylinositol turnover, effect of substance P Radical (rat), 18, 78 free, formation: in reductive glycosidic cleavage of anthracycline Sarcolemma antibiotics, 17, 95 heart, taurine binding to (rat), 17,29S Receptor Sarcoplasmic reticulum activation by agonist, 18, 413 vesicles, effect of dibucaine on calcium fluxes (rabbit), 17, 61 agonist-affinity shift, 18, 193 Scatchard binding, estimates of epidermal growth factor and ligand affinities, model 17, 314 computer analysis: ligand competitive binding to albumin, 18, 230 -bound estrogens and metabolites in nucleus of isolated liver cell ligand binding to albumin fragments, 18,224 (rat), 18, 215 Scurvy central dopamine antagonists, active conformation, 17, 38 prevention by implantation of dialysis bag containing L-gulonolac- extraneural and neural, neurotensin binding: biological activity and tone oxidase (guinea pig), 18, 326 structure-activity relationships, 18, 11 Semidehydroascorbate heterogeneity, functional, 18, 362 product of enzymic conversion of dopamine to norepinephrine, 17, -mediated GTP-dependent process, adenylate cyclase inhibition 421 (rat), 18, 598 Semidehydroascorbate reductase physical state, effect on opiate binding (rat), 17, 290 coupling to dopamine /3-hydroxylase, 17, 421 saturation by decamethonium, muscarone, and a-bungarotoxin, 18, Semiquinone 413 free radical, 18,94 Red blood cells, see Erythrocytes Semiquinone-imine Reduction free radical, 6-aminodopamine, 18,S94 cytidine 5’-diphosphate by ribonucleotide reductase, kinetics, 18,507 Serotonin metromdazole, by xanthine oxidase: metabolites from, 18, 105 mescaline analogs, similar to, 18, 455 SUBJECT INDEX 629

secretion, blood platelets: effect of pH (rat), 17, 356 Taurine uptake binding sites of cardiac sarcolemma, role in calcium regulation (rat), characterization and kinetics, 18, 447 17, 295 effects of temperature, ions, and drugs, 18,447 TCDD, see 2,3,7,8-Tetrachiorodibeum-p-dioxin system, evidence for pinealocyte suspensions (bovine), 18,438 Temperature Serum acclimation, neural membrane muscarinic sites (frog), 17, 141 albumin, see Albumin, serum effects on binding, 18,341 proteins, propranolol binding (human), 17, 187 Testosterone Site hydroxylation, reconstituted system: by cytochrome P.450 from neo- responsible for binding, ,8-adrenergic drugs, 17, 339 natally imprinted rats, 18, 543 Skin 2,3,7,8-Tetrachlorodibenzo-p-dioxin epidermal strips, adenosine-induced alterations in adenosine 3’,5’- effects on metabolism ofaflatoxins B, and B2 (mouse, inbred strains), monophosphate (human, mouse), 18,49 18, 296 Sodium induction of Na-Na exchange in axon (squid), 17, 350 cytochrome P450 in kidney and lung microsomes (rabbit), 18, 565 ouabain-sensitive Na efflux from axon, inhibition by AR-L 57 glutathione transferase (mouse), 18, 559 (squid), 17, 350 toxicity, segregation with Ah locus (mouse), 17,86 pump, inhibition by cardioactive drug (squid), 17, 350 Tetragastrmn Sodium iodide interaction with dibutyryl cyclic GMP (rat), 17,268 dissociation of[3H]ouabain-Na,K-adenosinetriphosphatase complex, i9-Tetrahydrocannabinol 18,259 effects on excitable membranes and neuromuscular transmission Spin trapping (frog), 17, 344 cumene hydroperoxyl radical, 17, 233 Theophylline superoxide, 17, 239 inhibition of adenosine-induced increase in cyclic AMP levels in Stability epidermal strips (human, mouse), 18,49 thermal, ligand-mediated: estrogen receptor when complexed with Thermodynamics estrogens or antiestrogens, 18, 406 of binding, agonist and antagonist interactions with f-adrenergic Steroids receptors, 18,341 porphyrin-inducing and membrane fluidizing actions, in embryo liver nI.iodohydroxybenzylpindolol binding in erythrocyte (turkey) and cells (chicken), 18, 144 heart (rat), 17, 1 Structure-activity relationships 1-Thiocarbamoyl-2-imidazolidinone acylcholine derivatives, 18, 20 immunoregulation, 18, 313 digitalis analogs, 17, 43 immunosuppres8ion, 18, 313 emetine, cryptopleurine, and tylocrebrine, 18, 136 isolation, characterization, and synthesis, 18, 313 eseroline and morphine, 18,461 Thiophthalane mescaline analogs, 18, 455 inhibitors of norepinephrine uptake, 17, 321 neuroleptic drugs, 5-aryltetrahydro-y-carboline series, 17,38 Thioredoxin neurotensin and analogs, 18, 11 in cytidine 5’-diphosphate reduction by ribonucleotide reductase, phthalane and thiophthalane inhibitors of norepinephrine uptake, kinetics, 18, 507 17,321 Thymidine progesterone derivatives, and digitalis receptor binding, 18, 402 modulation of methotrexate toxicity (cell culture), 18, 281 Styrene, 7,8-oxide Thymus substrate for liver glutathione tranaferase (mouse), 18, 559 DNA, incorporation of trifluorothymidine in a cell-free system: no Subcellular fractionation chain termination (bovine), 18, 148 phosphopolypeptides (glioma cells), 18, 427 DNA polymerase-a, regulation (bovine), 17, 256 Substance P Thyroid and related peptides, effects on salivation and phosphatidylinositol effect on ornithine decarboxylase activity in developing heart (rat), turnover in salivary glands (rat), 18, 78 18, 247 Substance P receptor status, effects on fat cell ,8-adrenergic receptors (rat), 18, 193 assay for activity, screening procedure for potential agonists and Tilorone antagonists (rat), 18, 78 effect on cytochrome P450 heme turnover (rat), 17, 395 rat salivary glands, 18, 78 Tissue Superoxide histamine levels, effect of lipid-soluble anticancer folate antagonists, formation 18, 100 by actinomycin D and spin-labeled derivatives, 17, 432 Tolerance in metromdazole reductive metabolism (rat), 17, 239 ethanol, reversibility and cross-tolerance (mouse), 17, 52 production by liver nuclei (hamster), 18, 588 lack ofdependence, multiple opiate receptors in vas deferens (mouse), Superoxide dismutase 18,39 hamster liver nucleus, 18, 588 Transglutaminase Synaptosomes role in internalization of fl-adrenergic receptor recognition sites, 18, hypothalamus: norepinephrine uptake, effect of phthalane and 348 thiophthalane inhibitors (rat), 17, 321 Translocation striatum, presynaptic regulation of tyrosine hydroxylase activity by nucleus, in vitro: estrogen receptor in male (rat), 17, 31 dopamine analogs (rat), 18,91 Transport alterations, methotrexate: growth phase dependence (leukemia cell culture), 18, 274 T axoplasm, fast: inhibition by delayed neurotoxic organophosphorus Tachyphylaxis esters (rat), 17, 56 to epinephrine (BHK cells), 18, 370 ion, magnesium, 18, 379 630 SUBJECT INDEX

nucleoside, inhibition by dipyridamole and ni V (HeLa cells), 18, 40 Valproate Tri-o-cresyl phosphate interaction with phenytoin, binding to serum albumin (human), 18, effect on fast axoplasmic transport (rat), 17, 56 237 Tricycic inhibitors Vas deferens of norepinephrine uptake, 17, 321 multiple opiate receptors, lack of cross-tolerance on (mouse), 18,39 Trifluoperazine Verapamil effect on (Ca2 + Mg1-adenosinetriphosphatase activity, 18, 253 taurine antagonist (rat), 17, 295 Trifluorothymidine Vesicles incorporation into thymus DNA in a cell-free system: no chain sarcoplasmic reticulum, effect ofdibucaine on calcium fluxes (rabbit), termination (bovine), 18, 148 17, 61 1,24(R),25-Trihydroxycholecalciferol Viruses effect on intestinal calcium-binding protein (rat), 17, 362 simian virus 40, treatment with antitumor drugs: DNA damage, 17, d-Tubocurarine 388 peripheral site ligand, modulation of acetylcholinesterase activity Vitamin C, see Ascorbic acid (electric eel), 18, 33 Tumor Novikoff, ribonucleotide reductase from (rat), 18, 507 W Tylocrebrine Water cross-resistance studies, 18, 136 interaction energy with: eseroline and morphine, 18, 461 Tyrosine hydroxylase, see Tyrosine 3-monooxygenase Tyrosine 3-monooxygenase pheochromocytoma cells, purification and characterization (rat), 17, X 79 Xanthine presynaptic regulation, by dopamine analogs, 18, 91 derivatives rat strmatal synaptosomes, 18,91 enhancement of diaphragm contraction (rat), 17, 73 U phosphodiesterase inhibition by (rat), 17, 73 Uracil-DNA glycosylase inhibition of fibroblast cyclic AMP escape and cyclic nucleotide role in 5-fluorodeoxyuridine metabolism in tumor cells (human), 18, phosphodiesterase activities (cell culture), 18, 57 513 Xanthine oxidase Uridine bovine milk, 17, 95 transport, inhibition by nitrobenzylthioinosine, dipyridamole, and interactions with anthracycline antibiotics, 17, 95 idoflazine (HeLa cells), 18,40 milk, metabolites from reduction of metromdazole by, 18, 105 Urogastrone receptor action of derivatives, 17, 314 Z Uterus estrogen receptor, thermal stability when complexed with estrogens Zinc or antiestrogens (rat), 18, 406 ions, actions in prostate gland (mouse), 17, 156 isolated smooth muscle, photoaffinity labeling of angiotensin II re- Zn2, peripheral site ligand modulation of acetylcholinesterase activ- ceptors (rat), 18, 210 ity (electric eel), 18, 33

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Specific areas of interest include: tereochemical, electronic, and other parameters of drug architecture; conformational analysis of receptors and their function; drug-enzyme and other interactions between drugs and macromolecules; drug effects upon gene replication and transcription and on protein 8ynthesis mechanism of action of antibiotics and other growth-inhibitory drugs induction by drugs of changes in macromolecular structure or allosteric transitions drug-induced alterations in metabolic pathways effects of hormones and other drugs on cellular regulatory mechanisms chemical mutagenesis, carcinogenesis, and teratogenesis; pharmacogenetics, idiosyncrasies, and drug allergies selective toxicity in a single organism or in different 8pecies; drug actions on properties and functions of membranea mechanisms of drug metabolism; distribution and transport of dnig molecules between biological compartments

“Short Communications” will be considered for rapid publication if their subject matter lies within the scope of the Journal, if they are concise, and if they are considered to be of sufficiently immediate importance to the work of other investigators to justify accelerated publication. They may contain experimental observations, theoretical material, or significant comment upon published investigations.

Page Charge8. Authors will be billed at the rate of $30.00 per is to allow authors maximum freedom in organizing and presenting page after the paper has been published. It is expected that the page their material, and in expressing their ideas, provided only that charge will be paid if funds are available for that purpose from the clarity and conciseness are achieved. author’s institution or from the sponsor of this research. Payment Certain conventions must be observed. Chemical and mathemat. of the charge is not a condition for publication. Neither the editors ical formulas and abbreviations should follow the Instructions to nor the reviewers will have knowledge as to who has paid the Authors oldie Journal ofBiological Chemistry (VoL 246, pp. 1-8, charge, and this payment will always be considered entirely volun- January 10, 1971). Drugs must be referred to by their genetic or ty. chemical names throughout the text, but may be identified by trade Submission ofmanuscrpt. Manuscripts are published in English name in parenthesis or a footnote. The systematic name and number only and should be sent to the Editor, Dr. Norman Kirshner, given by the commission on Enzymes of the International Union of Department ofPharmacology, Duke University MediCal Cen- Biochemistry should be included for each enzyme of importance in ter, Durham, North Carolina 27710, U.S.A. Manuscripts should a paper, at the point in the Summary or Introduction where the be typewritten double spaced with ample margins on one side of the enzyme is first mentioned. The use of abbreviations should be paper, 8#{189}x 11 inches (ca. 215 x 280 mm). Submit three complete minimized and abbreviations avoided in the Summary. All essential copies of the manuscript and three copies of each figure, plus one abbreviations should be defined in a single footnote when first original drawing or photograph of each figure. All pages should be introduced. Abbreviations of journal names should conform to the numbered consecutively beginning with the title page. Limit your style of Biological Abstracts. References to papers that have been reference listings to the minimal number required to adequately accepted for publication, but have not appeared, should be cited like document the manuscript. In most instances 30 references or less other references with the abbreviated name of the journal followed should suffice. by the words “in press.” Copies of such papers should be sent It is understood that the manuscripts and the results they contain whenever the findings described in them have a direct bearing on will not have been published previously and are not being submitted the paper being submitted for publication. “Personal Communica- elsewhere. Manuscripts are accepted for review with the under- tions” and “Unpublished Observations” should be cited in footnotes standing that all persons listed as authors have given their approval to the text and should not be included in the reference list. for the submission of the paper, further, that any person cited as a A manuscript should include the following, in the order listed: (1) source of personal communications has approved such citation. Title. Numbered footnotes to the title should be avoided; acknowl- Written authorization may be required at the Editor’s discretion. edgment of financial support should be given in an unnumbered Articles and any other material published in Molecular Pharma- footnote to the title. (2) Names of authors, their laboratory and cology represent the opinions of the author(s) and should not be institution. (3) A running title, not exceeding 60 characters and construed to reflect the opinions of the Editor(s) and the Publisher. spaces. (4) Summary preceded by authors’ names and title of article. If and when a manuscript is published, it will become the sole For example:’ property of the Journal. SUMMARY Authors submitting a manuscript do so on the understanding that if it is accepted for publication, copyright in the article, including DAIRMAN, W., AND S. UDENFRIEND. Studies on the mechanism of the right to reproduce the article in all forms and media, shall be the L-3,4-dihydroxyphenylalanine-induced decrease in tyrosine hy- assigned exclusively to the Society for Pharmacology and Experi- droxylase activity. MoL Pharmacol. 8: 293-299 (1972). mental Therapeutics. No reasonable request by the author for (5) Text. Footnotes should be referred to by superscript numbers permission to reproduce any of his or her contributions to the and references by numbers in parentheses. (6) References, num- journal will be refused. bered according to order of citation in the text, including title and Organization and style ofmanuscript8. The policy ofthe Journal complete pagination. Examples: 1. Goren, J. H., L G. Bauce and W. Vale. Forces and structural limitations of binding of thyrotropin- These should be unmounted glossy photographs (or original India. releasing receptor the pyroglutamic acid moiety. MoL Pharmacol. ink drawings). Usually figures will be reduced to one column width 13: 606-614 (1977). 2. SandIer, M. Variations in monoamine oxidase (3.5 in. or 89 mm) and all numbers after such reduction should be activity in some human disease states in Monoamine Oxidase and at least 1.5 mm high. The figures must be ready, in all respects, for Its Inhibition. Ciba Foundation Symposium 39. Elsevier, Amater- direct reproduction: no lettering or other art work will be done by dam, 327-340 (1976). (7). Footnotes, numbered according to order the publisher. 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The Editors are very section, or under another table or figure). Footnotes to tables should much interested in having accepted contributions appear in the appear beneath the tables themselves and should be designated by earliest possible issue of the Journal, and therefore request that lower-case italic superscript letters, a, b, c, etc. galley proof be returned within 24 hours after its receipt. In excep- tional cases, a “Note added in proof’ may be attached and will be Figures. These should be numbered with arabic numerals. Each published if the Editor approves. Authors receive 25 reprints free; of the three manuscript copies should contain all the figures, but information about ordering additional reprints will be mailed with only the original set need be of quality suitable for reproduction. galley proof.