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Amgalan et al

of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and crosis factor are conveyed through tumor necrosis factor receptor-associ- interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation. J Biol ated factor 2 in the heart. Circ Heart Fail. 2010;3:157–164. doi: 10.1161/ Chem. 2010;285:5347–5360. doi: 10.1074/jbc.M109.076976. CIRCHEARTFAILURE.109.899732. 7. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, 10. Luedde M, Lutz M, Carter N, Sosna J, Jacoby C, Vucur M, Gautheron J, Harper JW. Landscape of the PARKIN-dependent ubiquitylome in re- Roderburg C, Borg N, Reisinger F, Hippe HJ, Linkermann A, Wolf MJ, Rose- sponse to mitochondrial depolarization. Nature. 2013;496:372–376. doi: John S, Lüllmann-Rauch R, Adam D, Flögel U, Heikenwalder M, Luedde T, 10.1038/nature12043. Frey N. RIP3, a kinase promoting necroptotic cell death, mediates adverse 8. Yang KC, Ma X, Liu H, Murphy J, Barger PM, Mann DL, Diwan A. Tumor remodelling after myocardial infarction. Cardiovasc Res. 2014;103:206– necrosis factor receptor-associated factor 2 mediates mitochondrial au- 216. doi: 10.1093/cvr/cvu146. tophagy. Circ Heart Fail. 2015;8:175–187. doi: 10.1161/CIRCHEARTFAIL- 11. Lee P, Sata M, Lefer DJ, Factor SM, Walsh K, Kitsis RN. Fas pathway is a URE.114.001635. critical mediator of cardiac myocyte death and MI during ischemia-reper- 9. Burchfield JS, Dong JW, Sakata Y, Gao F, Tzeng HP, Topkara VK, Entman fusion in vivo. Am J Physiol Heart Circ Physiol. 2003;284:H456–H463. doi: ML, Sivasubramanian N, Mann DL. The cytoprotective effects of tumor ne- 10.1152/ajpheart.00777.2002.

Pennsylvania , In 1751, and Dr Thomas Bond founded Pennsylvania Hospital, the nation’s first. The hospital has been an ­innovator in patient care, education, and research. Pennsylvania hospital is home to America’s first medical library and surgical amphitheater. Distinguished alumni of its residency program include John Gibbon, Jr, the developer of the heart-lung machine, a breakthrough that ushered in the era of modern cardiac surgery. The 534-bed hospital is located in the historic Society Hill section of Philadelphia and is a major of the Perelman School of Medicine at the University of Pennsylvania. It has a national reputation in internal medicine, orthopedics, cardiovascular diseases, neurosurgery, otorhinolaryngology, , and /gynecology. Visitors may take advantage of guided tours and view ’s historic painting, “Christ Healing the Sick in the Temple,” as well as the historic library and surgical amphitheater. Syed Yaseen Naqvi, MD, MSc Department of Internal Medicine Pennsylvania Hospital University of Pennsylvania Philadelphia Sheldon Goldberg, MD Department of Cardiology Pennsylvania Hospital University of Pennsylvania Philadelphia

746 August 22, 2017 Circulation. 2017;136:743–746. DOI: 10.1161/CIRCULATIONAHA.117.029566