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Welcometo the 2013 Annual Report of the Abramson Cancer Center

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Welcometo the 2013 Annual Report of the Abramson Cancer Center welcome to the 2013 Annual Report of the Abramson Cancer Center. Every researcher, every physician who cares for cancer patients, appreciates the complexity of cancer. We know now that we are confronting hundreds or even thousands of diseases, that every cancer is in some ways unique. We know too that the causes of cancer, the intricate changes that occur when a cell is transformed from normal to malignant, are connected in fundamental ways to what make us living organisms—human beings. At the Abramson Cancer Center, we are using this rapidly emerging understanding of the amazing world within each of us to seek new ways to diagnose, treat and ultimately prevent cancer. Today, cancer research and treatment require teams of experts, working together, sharing ideas about how to use our knowledge of genetics, of the immune system, of cellular biology, to develop new approaches to treating cancer. Each new discovery opens new doors, and leads us to ask new questions about why things work the way they do and what we can today we can achieve better do as individuals, and as a team, to improve the care we offer every single one of our patients. outcomes both in treating many We know that the cures for cancer will come from within—from understanding the biology and genetics of these diseases, from being able to use our defenses to fight them, from the expertise cancers and in assuring a better and commitment of our researchers and clinicians, and from the extraordinary courage and determination of our patients and their families. quality of life for our patients using In this year’s Annual Report, we are highlighting several of the people and programs at the Abramson Cancer Center who are leading the way as we explore this world within us and apply new technologies that allow us that knowledge to developing precision medicine—personalized treatment plans for every patient that represent the best care available today and tomorrow. to do more with less. these new You may also view this report on the Web. To see and hear the remarkable stories of the doctors, approaches are precise and scientists, patients—and about the generous, visionary donors who are helping to make this work possible, visit PennMedicine.org/Abramson/AnnualReport. targeted and are built on our new understanding of the biology and Chi V. Dang MD, PhD behavior of cancer. Director, Abramson Cancer Center John H. Glick, MD Abramson Cancer Center Director’s Professor Pennsylvania New Jersey History Penn medicine’s Abramson Cancer Center was established in 1973 when a small group Doylestown Hospital Monmouth Medical Center of dedicated cancer specialists founded Penn’s Cancer Center. building on our rich Penn Medicine Valley Forge Lancaster General Hospital history of cancer research, including pioneering discoveries such as the Philadelphia Community Medical Holy Redeemer Hospital Center (Toms River) Abramson Cancer Center chromosome, this small group has grown to include highly respected medical, surgical Chestnut Hill Hospital Phoenixville Hospital Penn Presbyterian Medical Center and radiation oncologists, scientists, specialized nurses and many other dedicated Chester County Hospital Kennedy Health System (Cherry Hill) cancer care providers offering patients new and innovative treatments in an integrated, Abramson Cancer Center Pennsylvania Hospital Hospital of the University of Pennsylvania compassionate environment. Kennedy Health System (Stratford) Kennedy Health System (Washington Township) table of contents About the Abramson Cancer Center coalesces the cancer care and research efforts of Penn 4 Finding the Answer Within medicine, including: Perelman Center for Advancedm edicine, smilow Center for translational research, roberts Proton therapy Center, Hospital of the University of Pennsylvania, Penn 8 Fighting Cancer from the Inside Out Presbyterian medical Center, Pennsylvania Hospital, and Chester County Hospital. the Bayhealth Medical Center (Dover) Shore Memorial Hospital 14 Prevention to Prognosis Abramson Cancer Center has been continuously designated as a Comprehensive Cancer Center by the national Cancer Institute (nCI) since 1973. one of only 41 such Centers in Bayhealth Medical Cape Regional Medical Center 20 More with Less the country, the Abramson Cancer Center was rated “eXCePtIonAL” by the nCI at our Center (Milford) last competitive review—the highest possible rating a Center can receive. Delaware 28 A Cause for Collaboration The Abramson Cancer Center is the cornerstone of the Penn Cancer 32 Community Outreach Misson Network, a select group of regional hospitals with whom the Abramson Penn’s Abramson Cancer Center is dedicated to the eradication of cancer as a cause of 36 Ensuring Quality Cancer Care Cancer Center collaborates to provide human disease and suffering. Its mission is achieved through the following objectives: excellence in patient care, research 37 Funding & Volume Statistics Development and support of cancer- R ecruitment and support of new faculty and education in the community. focused research programs that are with a commitment to cancer research 38 Partners in Hope interdisciplinary and interdepartmental Facilitation of investigator collaboration Abramson Cancer Center in nature within and among research Programs Director’s Leadership Council | 40 E xpansion and integration of Development and management of Young Friends of the cancer-related patient services and shared resources Abramson Cancer Center | 41 interdisciplinary clinical programs Acquisition and allocation of laboratory Honor Roll & Lasting Tribute | 42 Development and support of inter- space for active cancer researchers Abramson Cancer Center at Valley Forge Gift of Hope | 60 departmental educational programs In 2012, we saw the opening of the Abramson Cancer Center at this mission was strengthened in 1998 when the Abramson family made a $100 million Penn Medicine Valley Forge, bringing the expertise and prominence of one of the nation’s leading cancer centers to Chester County— commitment to support compassionate, comprehensive cancer research and care at The Abramson Cancer Center of the University of Pennsylvania is one of Penn. today, due to the ongoing philanthropic support of the Abramson family and including the most advanced treatments, groundbreaking research a select group of cancer centers in the country awarded the prestigious many other dedicated grateful families, Penn medicine’s Abramson Cancer Center is and the compassionate care of leading experts. designation of Comprehensive Cancer Center by the National Cancer an internationally renowned cancer center. Institute. This status reflects our outstanding research, clinical services, education and information services and community outreach. 2 3 FINDING THE ANSWER WITHIN Penn’s Center for Personalized Diagnostics Charts New Course for Cancer Treatment not that long ago, the idea of analyzing someone’s DnA was futuristic. the future is today at the Abramson Cancer Center. our Center for Personalized Diagnostics uses the latest DnA sequencing technology to analyze patients’ tumors at their most basic genetic level. this level of analysis results in a genetic map that guides us in our treatment journey. this map is extraordinary because it is tailored to each individual. Why is this Important? more information leads to more successful treatments and better overall health outcomes. better outcomes include both those that extend life and those that improve quality of life. even when prognosis is good, chemotherapy can be brutal. through molecular analysis, we match patients with the most effective treatments. We are better able to select the best therapeutics, determine the right dosage, and avoid treatments that are known to have little impact on cancers with a certain genetic profile, thereby sparing patients a harmful experience with minimal chance of success. Judith Matthews 4 melanoma survivor, Abramson Cancer Center 5 FINDING THE ANSWER WITHIN Why Personalized Diagnostics? Today Every cancer is unique. The lesson of the past twenty years of cancer research is that Chi V. Dang, MD, PhD Today, advanced pathologic approaches, like those used by Penn‘s cancer is not one disease. It is many diseases. We seek to understand each patient’s Director, Abramson Cancer Center Center for Personalized Diagnostics (CPD), are transforming tumor, not just by how it appears on an x-ray but by what we can learn about its cancer care. This state-of-the-art center provides clinicians with “The question now is do different cancers actually cellular and genetic make-up. detailed genetic analysis of individual patient tumors. For the first have their own molecular characteristics. Can we time, scientists can sequence large panels of genes for multiple exploit these different personalities and treat them The answer is within: this basic biological information provides valuable clues to targets at the same time. The result is an astounding level of in an individual way for individual patients?“ determine the best course of treatment. Personalized diagnostics is only possible information about a patient’s tumor that can be used by clinicians because physicians and laboratory scientists work together. to determine the best treatment plan. Looking Back For David Roth, MD, PhD, who directs the Center, this work David Roth, MD, PhD represents the merging of basic science expertise and a Judith’s Story: “I Can Talk With My Doctors” Clues to the origin of cancer eluded physicians for centuries before the mid-19th Simon Flexner
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