Drug Formulary Commission DRAFT: List of Non-Opioid Pain Medications June 2, 2016

Acetaminophen (various Tylenol® products)

Acetaminophen/aspirin (Excedrin® Back and Body)

Acetaminophen/aspirin/caffeine (various Excedrin® products)

Angiotensin-Converting Enzyme Inhibitors (ACE-I): (migraine prophylaxis- off-label)  Enalapril (Vasotec®)  Lisinopril (Prinivil®, Zestril®)

Anticonvulsants:  Carbamazepine (Carbatrol®, Epitol®, Tegretol®, Tegretol XR®)  Divalproex sodium (Depakote®, Depakote ER®)  Gabapentin (Gralise®, Horizant®, Neurontin®)  Lacosamide (Vimpat®)- off-label  Lamotrigine (Lamictal®, Lamictal ODT®, Lamictal XR®)- off-label  Levetiracetam (Keppra®, Keppra XR®)- off-label  Oxcarbazepine (Trileptal®)- off-label  Phenytoin (Dilantin®)  Pregabalin (Lyrica®)  Topiramate (Topamax®, Trokendi XR®)  Valproic acid (Depakene®)  Zonisamide (Zonegran®)- off-label

Antidepressants:  Amitriptyline  Bupropion hydrochloride (Wellbutrin®, Wellbutrin XL®, Wellbutrin SR® Forfivo XL®, Zyban®)- off-label  Bupropion hydrobromide (Aplenzin®)- off-label  Clomipramine (Anafranil®)  Desipramine (Norpramin®)  Doxepin- off-label  Duloxetine (Cymbalta®)  Fluoxetine (Prozac®, Prozac Weekly®, Sarafem®)  Fluvoxamine- off-label  Imipramine (Tofranil®, Tofranil-PM®)- off-label  Maprotiline- off-label  Milnacipran (Savella®)  Mirtazapine (Remeron®)- off-label  Nortriptyline (Pamelor®)- off-label  Paroxetine (Paxil®, Paxil CR®)- off-label  Sertraline (Zoloft®)- off-label  Venlafaxine (Effexor XR®)- off-label

Beta Blockers (migraine prophylaxis):  Atenolol (Tenormin®)  Bisoprolol (Zebeta®)- off-label  Metoprolol (Lopressor®)  Nadolol (Corgard®)- off-label  Nebivolol (Bystolic®)

Drug Formulary Commission DRAFT: List of Non-Opioid Pain Medications June 2, 2016

 Pindolol- off-label  Propranolol (Innopran XL®, Inderal LA®)  Timolol

Calcium Channel Blockers:  Nicardipine (migraine- off-label)  Nimodipine (cluster headache- off-label)  Verapamil (Calan®, Calan SR®, Verelan®, Verelan PM®): (migraine prophylaxis)

Ergot Alkaloid  Dihydroergotamine (Migranal®)- nasal spray

Nonsteroidal Anti-inflammatory Drugs (NSAIDs):  Aspirin  Celecoxib (Celebrex®)  Diclofenac (Voltaren®)- gel  Diclofenac (Dyloject®)- injection  Diclofenac (Cambia®, Voltaren XR®, Zipsor®, Zorvolex®)- oral  Diclofenac (Pennsaid®)- topical solution  Diclofenac (Flector®)- transdermal patch  Diclofenac/misoprostol (Arthrotec®)  Diflunisal  Etodolac  Fenoprofen (Nalfon®)  Flurbiprofen  Ibuprofen  Ibuprofen/famotidine (Duexis®)  Indomethacin (Indocin®, Tivorbex®)  Ketoprofen  Ketorolac- oral, injection  Ketorolac (Sprix®)- nasal spray  Meclofenamate  Mefenamic acid (Ponstel®)  Meloxicam (Mobic®, Vivlodex®)  Nabumetone  Naproxen (Naprosyn®, Naprelan CR®)  Naproxen/esomeprazole (Vimovo®)  Oxaprozin (Daypro®)  Piroxicam (Feldene®)  Salsalate  Sulindac  Tolmetin

Neuromuscular Blockers  onabotulinumtoxinA (Botox®)  abobotulinumtoxinA (Dysport®)  rimabotulinumtoxinB (Myobloc®)  incobotulinumtoxinA (Xeomin®)

Serotonin 5 HT-1 agonist (Triptans)  Almotriptan (Axert®)- oral

Drug Formulary Commission DRAFT: List of Non-Opioid Pain Medications June 2, 2016

 Eletriptan (Relpax®)- oral  Frovatriptan (Frova®)- oral  Naratriptan (Amerge®)- oral  Rizatriptan (Maxalt®, Maxalt MLT®)- oral  Sumatriptan (Alsuma®, Imitrex®, Onzetra Xsail®, Sumavel Dosepro®, Zecuity®, Zembrace Symtouch®, Zomig®, Zomig ZMT®)- injection, nasal powder, nasal spray, oral, transdermal  Sumatriptan/naproxen (Treximet®)- oral  Zolmitriptan (Zomig®, Zomig ZMT®)- nasal spray, oral

Skeletal Muscle Relaxants:  Chlorzoxazone (Lorzone®)  Cyclobenzaprine (Flexeril®)  Metaxalone (Skelaxin®)  Methocarbamol (Robaxin®)  Orphenadrine (Norflex®)

Topical Anesthetics:  Capsaicin cream, gel, lotion, jelly  Capsaicin (Qutenza®)- transdermal patch  Lidocaine jelly, ointment  Lidocaine (Lidoderm®)- transdermal patch  Lidocaine/prilocaine gel