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Home , Reticular cell, Reticular fiber

Tissues Classification Notes / Description / Size Picture / Illustration Tissue or Source 1 Picture / Illustration Tissue or Source 2 Picture / Illustration Tissue or Source 3 Picture / Illustration Tissue or Source 4 Picture / Illustration Tissue or Source 5 Picture / Illustration Tissue or Source 6

Label MAIN Sub Type Sub Type Sub Type Sub Type Sub Type source / reference

1. attatched to is composed of thick, closely packed bundles of fibrils oriented parallel to the long axis of the tendons. 2.The thick bands are the protein collagen while the thin dark threads are the protein elastic. 3. The fibers of areolar are arranged in no Connective Fibrous Loose Areolar NA particular pattern but run in all directions and form a loose network in the intercellular material. 4.It consist of , collagen fiber, and 5. This image is labeled with fibroblast, collagen fiber, macrophage and elastic fiber

Label FIBROUS LOOSE AREOLAR FIBROUS LOOSE http://www.astrographics.com/GalleryPrints/Display/GP2085.jp http://media-2.web.britannica.com/eb-media/35/60135-004- http://science.tjc.edu/images/histology/15_combined.jpg http://www.cvm.tamu.edu/acvp/Cholelithiasis/5.JPG http://faculty.une.edu/com/abell/histo/LooseCT.jpg source / reference g DC3C7D26.jpg

1. Adipose taken from the umbilical cord. 2. The edge of the have nucleus which is dark purple, adipose cell is white and around the lined light purple is cytoplasmic membrane. 3. This image shows anterior of the belly. 4. This is a histological section of mammary tissue from a Adipose NA nonpregnant woman: Label A = ; C = connective tissue sheaths running through the adipose tissue; D - ducts growing. 5. This image shows the arrow pointing to macrophage (blue), nucleus (purple), annd the large pointer in adipocyteup through the connective tissue sheaths.

UMBILICAL CORD 400X BELLY MAMMARY TISSUE http://www.udel.edu/biology/Wags/histopage/empage/eat/ima http://www.deltagen.com/target/histologyatlas/atlas_files/musc http://classes.ansci.illinois.edu/ansc438/Mamdevelop/ducts_C http://medinfo.ufl.edu/year1/histo/images/d14.jpg http://faculty.une.edu/com/abell/histo/adipostisw.jpg ge35U.JPG uloskeletal/adipose_tissue_white_40x.jpg T_adipose.jpg

1. A network of interlacing in dark purple and in light purple. 2. This consists of reticular fibers and reticular cells interlaced to form a lose network that helps give structure to organs. The black reticular fibers located between reticular cells. 3. The cells that make the reticular fibers are called reticular cells. 4. The reticular fibers are attached Reticular NA NA to the reticular cells, so the two components of reticular connective tissue are "fixed", they cannot move around. The other cells and tissue fluid can move around in the spaces between the reticular fibers. 5. The red arrows point to individual reticular fibers. The dark-colored dots scattered among the fibers are mostly reticular cells and lymphocytes.

STOMA LYMPH NODE http://virtual.yosemite.cc.ca.us/randerson/lynn%27s%20bioslid http://www89.homepage.villanova.edu/angelo.milicia/Anato http://www4.napavalley.edu/Projects/1799/04_Reticular_Lym http://washington.uwc.edu/about/faculty/schaefer_w/TISSUES http://www.austincc.edu/histologyhelp/tissues/images/tk400.jp es/115.jpg my//retic.jpg phNode_100x.jpg /reticular_connective_tissue.jpg g 1. The dark spots are nuclei of the fibroblasts that make the collagen fibers. 2. The bundles of collagen are all parallel to each other. The bar in this image shows you the width of this piece of dense regular connective tissue, which comes from a . 3. Dense regular connective tissue is stained light that makes up the tendon and . The cell bodies are darkly Dense Regular NA NA stained and elongated. 4. The fibroblast nuclei (stained purple) are quite flat. Arrows indicate three fibroblast nuclei. Fibroblast nucleus (fb nuc) is labeled, but you can see other nuclei. The collagen fibers (cf) are parallel to the arrow bar. The "art" label indicates an artifact--a place where the collagen fibers pulled apart slightly during processing.

TENDON LIGAMENTS TENDON/LIGAMENTS TENDON http://www.sacs.ucsf.edu/home/cooper/Anat118/ConnTiss/tend http://a- http://www.austincc.edu/histologyhelp/tissues/images/tm400.j http://faculty.une.edu/com/abell/histo/DenseRegCT2.jpg on.jpg s.clayton.edu/Biology/BIOL1151L/lab03/new_images/densere pg 1.The connective tissue below the epithelium lining the surface of the . Beneath the skin forming the mammae, dense connective tissue areas are very extensive. This tissue surrounds the resting mammary gland. 2. The characterized of tissue by the presence of densely packed, interwoven bundles of pink-stained fibers of various sizes. 3. This is Irregular NA NA typical dense irregular connective tissue, characterized by the interwoven network of various sized bundles of type I collagen fibers. The clear spaces are occupied by carbohydrate-rich that does not stain with iron hematoxylin. 4. This image shows the outer later of the heart. 5. The main component of dense irregular connective tissue. The fibroblasts that make the collagen fibers cannot be seen.

NON LACTATING MAMMARY DERMIS SKIN PERICARDIUM SKIN http://www.ucc.ie/bluehist/CorePages/Connective/Images/nip0 http://casweb.ou.edu/pbell/Histology/Images/Slides/Connectiv http://casweb.ou.edu/pbell/Histology/Images/Slides/Connectiv http://www.pc.ctc.edu/hart/ctprop/ctprimag/dirr.jpg http://faculty.une.edu/com/abell/histo/DenseirregCT.jpg 21he.jpg e/63.dense.irreg.20.jpg e/pl.dense.irreg.ct.IH.100.jpg

1. This image of a cross section through an artery shows the sinuous bundles of elastic fibers that are present in the muscular walls of these blood vessels. 2. Elastic fibers are visible because they stain purple. 3. Consists of freely branching elastic fibers, fibroblasts are present in spaces betweek Elastic NA NA fibers. 4. This image of a cross section through a portion of the wall of a large artery shows the sinuous bundles of elastic fibers that are present in the muscular walls of these blood vessels. The elastic fibers are dark because of special staining.

BLOOD VESSEL ARTERTY LUNG TISSUE LARGE ARTERY http://casweb.ou.edu/pbell/Histology/Images/Slides/Connectiv http://legacy.owensboro.kctcs.edu/gcaplan/anat/Histology/elas http://casweb.ou.edu/pbell/Histology/Images/Slides/Connectiv http://faculty.une.edu/com/abell/histo/elasticfibersw.jpg e/45.elast.c.t.40.JPEG tic2.jpg e/46.elastic.JPEG

1. Consist of bluish/white, shiny ground substance with fine collagen fibers and many chondrocytes. 2. Lacunae contain the chondrocytes, which are embedded in a smooth matrix. , which secrete the matrix, can be seen at the top of the micrograph. 3. Hyaline contains cells Supportive Cartilge Hyaline NA NA called chondrocytes embedded in a unique matrix that gives the tissue both strength and flexibility. Thechondrocytes housed in their spaces called lacunae. 4. Developing of fetal ribs and several chondrocytes. 5. The different layer are layered from connective tissue, perichondrium, chondrocytes and matrix.

LARYNX TRACHEA PERICHONDRIUM RIBS LONG BONE http://a- http://www.technion.ac.il/~mdcourse/274203/slides/Skeletal% http://microanatomy.net/bone/cartilage1.jpg http://microanatomy.net/bone/cartilage2.jpg http://www.med.mun.ca/anatomyts/msk/Bone18.gif s.clayton.edu/Biology/BIOL1151L/lab03/new_images/hyaline 20Tissues/1-Hyaline%20Cartilage%20-%20Trachea.jpg 1. Consists of chondrocytes located in a threadlike network of elastic fibers within the . 2. Elastic cartilage Lacunae containing the chondrocytes, which are characteristic of cartilage, are embedded in a matrix with elastic fibers. The fibers are dark pink. 3. The stain for that brings out the dense bundles. 4. Elastic cartilage is Elastic NA NA flexible. It is found in the epiglottis, pinna of the ear, auditory tube and eustachian tube. It is organized in a similar way to hyaline cartilage with a perichondrium and chondroblasts and chondrocytes embedded in a matrix. The major difference is in the matrix where branched elastin fibres are present in addition to collagen

AUDITORY TUBE EXTERNAL EAR EXTERNAL EAR EPIGLOTTIS http://a- http://www.technion.ac.il/~mdcourse/274203/slides/Skeletal% http://microanatomy.net/bone/ecartilage.jpg http://www.med.mun.ca/anatomyts/msk/Bone16.gif s.clayton.edu/Biology/BIOL1151L/lab03/new_images/elastic_ 20Tissues/2-Elastic%20Cartilage%20- 1. The lacunae are not as numerous in this cartilage and they are smaller. the nuclei of the chondrocytes is a red-purple color. 2. This image shows the fibrocartilage from an intervertebral disk. It is distinguished by very scattered, infrequent chondrocytes in dark cuclei collagen fibers running in the matrix. 3. In fibrocartilage the structure is intermediate between that of Fibro NA NA hyaline cartilage and dense connective tissue. It is found where are bound together such as at the pubic symphysis and as part of intervertebral discs. The cells are squeezed into rows by thick bundles of collagen fibres in the matrix. The collagen is orientated in the direction of stress. The gel component of the matrix is reduced compared to hyaline cartilage. 4. Here is tighter fibrocartilage from a pubic symphysis.

INTERVERTEBRAL DISK INTERVERTEBRAL DISK PUBIC SYMPHYSIS PUBIC SYMPHYSIS http://a- http://microanatomy.net/bone/fcartilage.jpg http://www.med.mun.ca/anatomyts/msk/Bone13.gif http://www.mhhe.com/biosci/ap/histology_mh/fibroc1.jpg s.clayton.edu/Biology/BIOL1151L/lab03/new_images/fibrous_ 1. There are two osteons in this micrograph. The dark and light ovals are the central canals or Haversian canals through which blood vessels and nerves project. Surrounding central canals are the lamellae with the osteocytes embedded in the solid calcium and phosphate matrix. The fine lines radiating out from the center are canaliculi. 2. This shows the architecture of Bone Compact NA NA compact bone which is designed to nourish and regulate osteocytes and bone matrix. 3. The osteon is labaled from inner to outer of haversion canal, lamella, canaliculi and lacuna. 4. The concentric layers of mineralized matrix called lamellae (Lm), surround the Haversian canal (Hc). Concentric arrays of almond-shaped lacunae (Lc) containing osteocytes are visible. Radiating from the Haversian canal in all directions are spaces or fine tubes called canaliculi (Cl). HUMERUS FEMUR TIBIA FIBULA http://a- http://kcfac.kilgore.cc.tx.us/kcap1/images/compact%20bone% http://www.bioimagingllc.com/images/13%20Compact%20Bo http://www.cytochemistry.net/microanatomy/bone/bone1.jpg s.clayton.edu/Biology/BIOL1151L/lab03/new_images/bone1.j 202%20fireworks%20b.jpg ne-Osteon%20400X.jpg

Sponge is made of bone or Trabeculae -{1} and the air is made of red -{3}; the marrow produces red blood cells, cancellous cavities which contain Osteoblasts -{2}, The trabeculae are surrounded by a layer called the Periosteum marked as {4}. 2. An electron micrograph scan of spongy bone in an osteoporosis patient. Osteoporosis occurs when a body's blood Spongy NA NA calcium level is low and calcium from bones is dissolved into the blood to maintain a proper balance. 3. Cancellous bone showing its bony trabeculae (pink) and marrow tissue (blue). 4. It contains large marrow spaces defined by shelves and spicules of bone. The inner space is lined by osteoblasts and osteoclasts.

LONG BONE OSTEOPEROSIS LONG BONE RIBS http://upload.wikimedia.org/wikipedia/commons/thumb/b/bc/S http://www.microscopy-uk.org.uk/schools/images/sbone.gif http://www.faqs.org/health/images/uchr_02_img0194.jpg http://www.cytochemistry.net/microanatomy/bone/spbone.jpg pongy_bone_-_trabecules.jpg/350px-Spongy_bone_-

1. Human red blood cells in red from a leg wound. 2. Red Blood cell(RBC) also referred to as erythrocytes are the most common type of blood cell. This scanning electron micrograph that have been magnified a little over 11,000 times. Being biconcave in shape allow RBCs to have a greater Fluid Blood Cells Erythrocytes NA surface area and carry more oxygen through your body. 3. Red blood cells (erythrocytes) trapped in a mesh of fibrin threads. Fibrin, a tough, insoluble protein formed after injury to the blood vessels, is an essential component of blood clots. 4. Ideal blood smear with neutrophil, lymphocyte and platelets.

BLOOD BLOOD RBC with FIBRIN BLOOD SMEAR http://www.astrographics.com/GalleryPrints/Display/GP2091.jp http://lh6.ggpht.com/_9F9_RUESS2E/SqpDdiLBcII/AAAAAAA http://media-2.web.britannica.com/eb-media/28/98328-004- http://www.fortunecity.com/greenfield/rattler/46/images/IDEAL g ABEE/ZNVbA8UwO1k/s800/Looking-at-the-World-through-a- 5514AFAC.jpg .JPG

1. This type of WBC secrete heparin and histamine. Heparin keeps from clotting and histamine stimulates inflammation. 2. Bluish lack granules of Leukocytes Basophil univorm size within the cytoplasm and typically a bilobate nucleus. 3. and basophil labeled. 4. Basophils constitue .5 to 3% of peripheral blood that release histamine and serotonin.

BASOPHILS HUMAN BLOOD HUMAN BLOOd BLOOD SMEAR http://www.worsleyschool.net/science/files/blood/whitebloodce http://upload.wikimedia.org/wikipedia/commons/f/f2/PBBasop http://farm4.static.flickr.com/3186/3069600235_0b80c9e8ac.j http://www.vghks.gov.tw/glab/images/Wbasophil.jpg ll.JPG hil.jpg pg

1. Eosinophils, platelets and RBC is labeled on this image. 2. Eosinophils-- 10 to 15 um diameter and constitute 2.0 to 4.0% of leukocytes. 3. These cells usually contain a bilobate (two lobes) nucleus and a cytoplasm full of brightly stained eosinophilic (orange-red) specific granules. 4. Eosinophils Eosiniphil function specifically as phagocytes to destroy larvae of parasites that have invaded tissues in trichinosis, schistosomiasis, and appear to play a role in allergic responses. Other functions of eosinophils include phagocytosis of antigen antibody complexes.

HUMAN BLOOD HUMAN BLOOD HUMAN BLOOD HUMAN BLOOD http://eosinophilicesophagitis.files.wordpress.com/2009/03/eo http://www.spjc.edu/clw/math_science/Nicotera/pnic/Nicotera/ http://faculty.une.edu/com/abell/histo/eosinophil2.jpg http://www.vghks.gov.tw/glab/images/Weosinophil.jpg sinophil4.jpg?w=196&h=139 eosinophil1.jpg

1. The size of Neutrophil are 10 to 15 u diameter. 2. These cells constitute 70% of leukocytes and usually have 2 to 5 nuclear lobes connected by fine filaments of chromatin. Neutrophils are the most numerous of all leukocytes, 3. The cytoplasm is pink to grey because of the neutral staining of specific Neutrophil granules (i.e. they don't stain). 4. Neutrophils function as scavengers within extravascular tissue, destroying bacteria or other infectious organisms that invade the body. Neutrophils are also called Polymorphonuclear Leukocytes (PMNs) in some laboratories even though the following two cell types also have multi-lobed nuclei.

HUMAN BLOOD HUMAN BLOOD HUMAN BLOOD HUMAN BLOOD http://www.spjc.edu/clw/math_science/Nicotera/pnic/Nicotera/ http://www4.napavalley.edu/Projects/1799/13_Neutrophils_40 http://faculty.une.edu/com/abell/histo/neutrophil.jpg http://www.vghks.gov.tw/glab/images/Wnetrophil.jpg neutrophil1.jpg 0X.jpg 1. T lymphocytes in green are involved in the specific immune response and are composed mainly of precursor T cells and B cells. 2. Subsets of lymphocytes that originated in the red bone marrow from hematopoietic stem cells 3. Lymphocytes - 9 to 14 um diameter Lymphocytes constitute 20 • 25% of agranulocytes and may be small, Lymphocyte medium or large in size. 4. The nucleus is rounded or oval, and usually the same size as an erythrocyte. The chromatin is densely packed with no apparent nucleoli. When compared with nuclei of other cells, the lymphocyte nucleus almost always appears smudged. 5. Stained blood smears you are using. Some lymphocytes migrate into the connective tissues and become Plasma Cells.

LEG WOUND BONE MARROW HUMAN BLOOD HUMAN BLOOD LARGE GRANULE http://www.astrographics.com/GalleryPrints/Display/GP2091.jp http://www.astrographics.com/GalleryPrints/Display/GP2145.jp http://faculty.une.edu/com/abell/histo/lymphocyte.jpg http://www.vghks.gov.tw/glab/images/Wlym.jpg http://www.vghks.gov.tw/glab/images/Wlargelym.jpg g g

1. Monocytes - 12 to 20 um diameter, and comprise 3 • 8% of agranulocytes. 2. This large cell has a lightly stained nucleus that often Monocyte appears horseshoe or kidney shaped. 3. The chromatin appears lacy and nucleoli are usually not apparent. 4. The abundant cytoplasm stain quite often contains vacuoles small, clear areas.

HUMAN BLOOD HUMAN BLOOD HUMAN BLOOD HUMAN BLOOD http://www4.napavalley.edu/Projects/1799/13_Monocyte_400 http://www.spjc.edu/clw/math_science/Nicotera/pnic/Nicotera/ http://faculty.une.edu/com/abell/histo/monocyte.jpg http://www.vghks.gov.tw/glab/images/Wmonocyte.jpg X.jpg monocyte1.jpg

1. Tissue in purple/pink is a mature phagocyte that can ingest invading microbes, foreign particle and cellular debris. 2. Cell is seeking foreign bacteria(Escherichia coli) with specialized cell extensions called filopodia 3. This image is labeled with the ferritin particles in phagocytic vacuoles. 4. Macrophage This low magnification image from the human umbilical cord shows the characteristic appearance of mucous connective tissue: sparsely scattered cells; sinuous collagen fibers; and lots of ground substance, which is unstained. About half of the nuclei seen belong to fibroblasts and the other half to , although it is usually not possible to tell them apart.

LEG WOUND LUNG ALVEOLAR HUMAN BLOOD UMBILICAL CORD http://www.astrographics.com/GalleryPrints/Display/GP2091.jp http://www.astrographics.com/GalleryPrints/Display/GP2008.jp http://www.sacs.ucsf.edu/home/cooper/Anat118/ConnTiss/ferri http://casweb.ou.edu/pbell/Histology/Images/Slides/Connectiv g g macro.jpg e/4.mucous.ct.20.JPEG

1. This image are comparason of the size of RBC, plateles and WBC. 2. They are irregular shaped, colourless bodies that are within our blood. The surface is sticky and with other substances, form clots to stop bleeding. The platelets gather at the wound and attempt to block the flow of blood.3. Platelets Human Red Blood Cells, Platelets and T-lymphocyte(erythocytes = red; platelets = yellow; T-lymphocyte = light green) 4. The average lifespan of a platelet is between 8 and 12 days. Platelets play a fundamental role in hemostasis and are a natural source of growth factors

HUMAN BLOOD HUMAN BLOOD YELLOW HUMAN BLOOD http://2.bp.blogspot.com/_C- http://home.comcast.net/~itpaware/images/bloodcells.jpg http://www.uic.edu/classes/bios/bios100/lectf03am/09032c.jpg http://www.marvistavet.com/assets/images/canine_platelets.gif kqNjYlVIo/SfN75UDbBsI/AAAAAAAAABU/j4fd9XE_RSM/s320/

1. Blood is a connective tissue consisting of cells suspended in an intercellular fluid (the blood plasma). 2.Blood functions to transport oxygen, carbon dioxide, nutrients, wastes, hormones, etc. to and from the body's Plasma cells. Blood cells consist of erythrocytes (red blood cells), leukocytes (white blood cells) and thrombocytes (platelets). 3.The above picture is a smear of human peripheral blood. 4. Final histological examination showed diffuse infiltration of mature and immature plasma cells in thyroid

BLOOD SMEAR HUMAN BLOOD TONSIL THYROID http://www.uoguelph.ca/zoology/devobio/miller/013633fig6- http://www.uni- http://www.uoguelph.ca/zoology/devobio/miller/013633fig6- http://www.nzma.org.nz/journal/119-1235/2005/content03.jpg 14.gif mainz.de/FB/Medizin/Anatomie/workshop/EM/eigeneEM/Tph 14.gif 1. Lymph nodules are unencapsulated lymphoid tissue located in several organs of the digestive and respiratory tracts, and all organs of the . They are composer of densely packed lymphocytes (mainly B- lymphocytes) that differentiate into plasma cells after appropriate antigenic stimulation. Secondary lymph nodules exhibit a pale staining germinal Lymph Lymph center, indicating that an antibody response to an antigen is occurring. Primary lymph nodules have not been activated, therefore, lack germinal centers. Peyer's patches are aggregates of unencapsulated nodules found in the lamina propria of the ileum. 2. Lymph nodes are spherical or kidney- shaped organs that are distributed throughout the body. The node is enclosed by a connective tissue capsule from which large connective tissue trabeculae arise and subdivide the underlying parenchyma. Each lymph ESOPHAGUS KIDNEY SPLEEN THYMUS http://www.bios.niu.edu/hubbard/kimhisto/lymphnode1%20co http://www.bios.niu.edu/hubbard/kimhisto/spleen2%20copy.jp http://www.bios.niu.edu/hubbard/kimhisto/thymus1%20copy.jp http://www.bios.niu.edu/hubbard/kimhisto/lymphnodule1.jpg py.jpg g g 1. This skeletal muscle cross section is preserved with a collagen stain to bring out the perimysium between the fascicles. Each muscle is composed of thousands of fibers (E), each with a covering of —endomysium (B). The fibers are organized in parallel bundles called fascicles (D). Each fascicle is surrounded by a perimysium sheath (A); the presence of collagen bundles suggests dense connective tissue. Multiple Muscle Skeletal fascicles are encased in a dense connective tissue—epimysium, which covers the entire muscle organ. Blood vessels, like the one shown at (C), and nerve fibers penetrate to the endomysium to supply the muscle fibers. 3. Longitudinal section of skeletal muscle: The individual muscle fiber (C) originates from a fused series (syncytium) of myoblasts surrounded by a common sarcolemma. Because of this, multiple nuclei (B) are found within CROSS SECTION CROSS SECTION LONGITUDINAL SECTION CROSS SECTION http://www4.napavalley.edu/Projects/1799/2_SkeletalMuscle_ http://srufaculty.sru.edu/timothy.smith/images/Mus1-skelmm- http://srufaculty.sru.edu/timothy.smith/images/Mus1-skelmm- http://washington.uwc.edu/about/faculty/schaefer_w/TISSUES 400X.jpg CS%202%20final%20copy.jpg LS%20final%20copy.jpg /skeletal_muscle2.jpg

1. Spindle shaped, thickest in the middle and tapering at both ends, non striated fibers with one nucleus. 2. Long, slender central nuclei, lying within narrow, fusiform cells that lie parallel to each other in a smooth arrangement. 3. Cells more separated so as to see their extent and shape better, and the Smooth central position of their nuclei. A loose, irregular connective tissue (endomysium) lies between the cells. Nuclei seen in this picture belong to fibroblasts mainly. 4. Smooth muscle with wrinkled nuclei due to contraction of cells.

STOMACH LUNGS GALLBLADDER UTERUS http://www.cas.vanderbilt.edu/bsci111b/muscle/smooth- http://www.francesdevoe.com/muscle9.jpg http://www.francesdevoe.com/muscle10.jpg http://www.francesdevoe.com/muscle11.jpg stained3953-small.jpg

1. Stem cells placed in the heart have morphed into cardiac muscle cells. 2. Heart muscle with purkinje fibers(green) on the surface, which originated Cardiac from the atrioventricular node and spread into the two ventricles. 3. Branched striated fibers with one or more centrally located nuclei containing intercalated discs. 4. The nucleus and the intercated disc are labeled.

STEM CELL HEART MUSCLE FIBER HEART MUSCLE CARDIAC MUSCLE http://media.collegepublisher.com/media/paper932/stills/425 http://2.bp.blogspot.com/_TJT_BnTlW54/STGTbdrtKEI/AAAA http://www4.napavalley.edu/Projects/1799/Ex9_Cardiac_Musc http://www.cytochemistry.net/microanatomy/muscle/muscle12. 55fc238351-28-1.jpg AAAABxs/lQAhS2FOSug/s320/purkinje_fibers_heart_images_ le_100X.JPG jpg

1. This image shows the neurons and the neuroglia. 2. Electron micrograph of a motor neuron. S = soma, or cell body; P = podite or cell extension; D = dendrite; arrow is at the axon. 3. Sensory neurons of the dorsal root ganglia Nervous Neurons allow us to detect stimuli to the body surface that lead directly to the sensations such as touch and pain. 4. Neurons consist of a cell body and processes extending from the cell body.

SPINAL MOTOR SENSORY SPINAL http://www4.napavalley.edu/Projects/1799/2_Neurons_40X.jp http://mdc.helmholtz.de/en/research/research_teams/molecul http://www.montgomerycollege.edu/~wolexik/Neuron-100x- http://faculty.fortlewis.edu/byrd_s/physiologyweb/genphy2.gif g ar_physiology_of_somatic_sensation/images/sensory_neuron 1.jpg 1. At high power, note the large neuron cell body, some of its surrounding satellite cells, and the Schwann cell nuclei associated with the nerve fibers entering or leaving this ganglion. 2. Canine spinal ganglion (H&E stain). Unipolar neuron cell bodies are surrounded by lemmocyte satellite cells (arrows). 3. The blue arrow are pointing to the satellite cells of the dorsal root Peripheral Neuroglia Satellite ganglion. 4. High power view of a section through part of an autonomic 2 types ganglion (Triple stain). Multipolar neuron cell bodies with eccentric nuclei (white arrows) are within poorly-defined capsules formed by lemmocyte satellite cells (red arrows). Axons (green arrows) can be seen leaving the cell bodies of two autonomic postganglionic neurons.

CELL BODY LEMMOCYTE DORSAL ROOT AUTONOMIC GANGLION http://vanat.cvm.umn.edu/neurHistAtls/cataPages/cataImages/ http://vanat.cvm.umn.edu/neurHistAtls/pages/images/PNS13.j http://zoomify.lumc.edu/histonew/neuro/dms093/28.gif http://www.ouhsc.edu/histology/Glass%20slides/4_05.jpg cataGlia10.jpg pg

1. The small nerves are most easily found at the periphery of the organ and running near blood vessels. They are generally surrounded by an intensely stained perineurium . The nerves have a wavy appearance and have many Schwann cell nuclei among the nerve fibers. 2. In the above picture, the dark Swhann Cell circles are schwann cells surrounding PNS axons creating a protective layer known as the myelin sheath. 3. Nerve Fibers growing through cylindrical schwann cell formation. 4. The dorsal root ganglion are labeled with myelinated nerve cell process and swhann cells.

PROSTATE PNS CNS DORSAL ROOT GANGLION

http://www.ouhsc.edu/histology/Glass%20slides/33_06.jpg http://blustein.tripod.com/Schwann_Cells/pn-xs-low.gif http://blustein.tripod.com/Schwann_Cells/nerve1sm.gif http://www.ouhsc.edu/histology/Glass%20slides/4_04.jpg

1. Spinal cord central canal (H&E stain). The central canal of the spinal cord is lined by ependymal cells which have cilia (arrows) that project into the lumen of the central canal. 2. The ventricles of the brain and the central canal of the spinal cord are lined with ependymal cells. The cells are often Central cilated and form a simple cuboidal or low columnar epithelium. The lack of Ependymal 4 types tight junctions between ependymal cells allows a free exchange between cerebrospinal fluid and nervous tissue. 3. The ependymal cells that make up the choroidal epithelium 4. Cells that line the Ventricle of the brain and the central canal of the spinal cord ependymal cells are ciliated cuboidal glial cells

SPINAL CHORD SPINAL CORD CEREBELLUM & MEDULLA SPINAL CORD http://vanat.cvm.umn.edu/neurHistAtls/cataPages/cataImages/ http://www.lab.anhb.uwa.edu.au/mb140/corepages/nervous/I http://www.csus.edu/org/nrg/carter/NeurosylActive/centcanal.jp http://www.ouhsc.edu/histology/Glass%20slides/9_08.jpg cataGlia6.jpg mages/epen100he.jpg g 1. This micrograph is of a section of brain stained using a Holzer stain, demonstrates the astrocytes with their many processes, giving them a star- shaped appearance (arrows). 2. This preparation allows visualization of even finer astrocytic processes. 3. This is an example of an anaplastic astrocytoma. 4.Cell bodies of astrocytes are among the largest for the glia, astrocytes but only overlap the lower end for size of neurons. 5. Astrocytes, known for the many processes attached to their cell body, provide structural support and their processes often have 'end feet' that abut the around the capillary endothelium or line the exterior surface of the CNS, where they contribute to the pial-glial external limiting membrane.

BRAIN ASTROCYTIC ASTROCYTOMA IN RED http://missinglink.ucsf.edu/lm/ids_104_cns_injury/Response% http://missinglink.ucsf.edu/lm/ids_104_cns_injury/Response% http://missinglink.ucsf.edu/lm/ids_104_cns_injury/Response% http://rettsyndrome.files.wordpress.com/2009/02/astrocyte2.jpg http://www.sci.uidaho.edu/med532/images/Neurons_Neurogli 20_to_Injury/Injury_Images/AstrocyteHoltzer.jpg 20_to_Injury/Injury_Images/Astrocyte1.jpg 20_to_Injury/Injury_Images/AnaplasticAstro.jpg ?w=125&h=158 a/md03_003-e2-e3.jpg

1. Cultivated oligodendrocytes (in green) and an intracellular marker (in red). ) Signaling pathways that modulate oligodendrocyte progenitor cell migration in the developing brain. 2) Signaling mechanisms that regulate oligodendrocyte differentiation and myelination. Oligodendrocytes 3) Identification of small molecules that enhance oligodendrocyte differentiation. This drug discovery project has identified compounds that enhance oligodendrocyte differentiation in cultured cells, and that enhance remyelination in demyelinated tissue. 4) differentiation can be imaged in manipulated experimentally.

http://www.uchsc.edu/cdb/images/research/macklin_files/EGF http://www.uchsc.edu/cdb/images/research/macklin_files/OPC. http://www.uchsc.edu/cdb/images/research/macklin_files/Oligo http://www.em.mpg.de/uploads/pics/oligodendrocyte_02.png P-cell.jpg jpg dendrocytes.jpg 1. This is a high-power view of two microglia stained with a silver method. This is what Rio-Hortega used when he first described this cell type in 1919. 2. Microglia are the smallest of the glial cells. Some act as phagocytes cleaning up CNS debris. Most serve as representatives of the immune system in the brain. Microglia protect the brain from invading microglia microorganisms and are thought to be similar in nature to microphages in the blood system. 3. They have spindley processes eminating from the central cell body. On H&E stain, all one would be able to see is a small rod- shaped nucleu 4. This H&E stained section shows a microglial nodule in a brain of a patient who died with AIDS. It is a common finding in patient with AIDS encephalopathy. Such nodules probably form in response to viral antigens: HIV itself and/or CMV. CNS CNS CEREBRUM AIDS ENCEPHALOPATHY http://missinglink.ucsf.edu/lm/ids_104_cns_injury/Response% http://www.technion.ac.il/~mdcourse/274203/slides/Nerve/1- http://missinglink.ucsf.edu/lm/ids_104_cns_injury/Response% http://blustein.tripod.com/Microglia/zweit.gif 20_to_Injury/Injury_Images/MicrogliaHortega.jpg Pyramidal%20neuron.jpg 20_to_Injury/Injury_Images/Microglialnodule.jpg 1. Simple squamous epithelium is made up of one layer of flat cells. This picture shows the lining of an artery. 3. These cells come off the stratified squamous epithelial tissue on the inner surface of the cheek. These cells show the irregular, flat shape characteristic of typical "squamous cells." The nucleus (A) is centrally located, the cell membrane (C) is very thin, and the Epithelial Simple Squamous cell is filled with cytoplasm (B). 4. A) line the walls of blood vessels; at the right it makes up the lung alveoli (A) wall.In both cases the cells are very thin.

LINING OF ARTERY KIDNEY CHEEK CELL ALVEOLI OF LUNG http://www.lima.ohio- http://www4.napavalley.edu/Projects/1799/03_Kidney_100x.j http://www.unomaha.edu/hpa/images/1cheek1.jpg http://www.unomaha.edu/hpa/images/1simpsqua.jpg state.edu/biology/images/anatomy/Simple%20Squamous%2 pg

1. Simple cuboidal epithelium is made up of one layer of cube-shaped cells. These cells frequently make up the tubes of your body. 2. This kidney tubules cut such that they appear as a ring of cell around empty space. The cuboidal cell (A): lines these tubules are as wide as they are tall as they are deep and (B): are the nudlei are easily observed. FUNCTIONS: secretion, Cuboidal excretion and absorption. 4. This tissue lines the tubules of the kidney. You can see the lumen (open area) and the single layer of cuboidal cells that enclose a tubule. The cells are cuboidal in shape with the nucleus in the center.

TUBES OF THE BODY KIDNEY TUBULE THYROID KIDNEY http://www.lima.ohio- http://www4.napavalley.edu/Projects/1799/3_Thyroid_100x.jp http://a- http://www.unomaha.edu/hpa/images/1cuboidal.jpg state.edu/biology/images/anatomy/Simple%20Cuboidal%20 g s.clayton.edu/Biology/BIOL1151L/lab03/new_images/cuboid

1. Human epithelium lining of the small intestine. Arrow shows the cilia. 2. The epithelium is ciliated in border. 3. This image is labeled with connective Columnar Ciliated tissue, , cilia, lumen 4. The establishment of a ciliated cell line will provide a valuable resource for the further studies of the Fallopian tube in the early events of pregnancy.

SMALL INTESTINE AMPULA OF OVIDUCT FALLOPIAN TUBE FALLOPIAN TUBE http://kcfac.kilgore.cc.tx.us/kcap1/images/simple%20columnar http://waukesha.uwc.edu/lib/reserves/pdf/zillgitt/zoo234/histol http://faculty.une.edu/com/abell/histo/ileumcol.jpg http://faculty.une.edu/com/abell/histo/ovid89.gif %20ciliated%20400x%20b%20fireworks.jpg ogy/ZOO%20234%20Ciliated%20Columnar%20Epithelium% 1. This image labeled the connective tissue, cucleus of columnar, goblet cell and the basement membrane. 2. This image labeled the basement membrane, connective tissue, goblet cell and the lumen of intestine(free edge, apical surface) 3. This tissue is characteristic of most of the GI tract. In this section of the large intestine, the lumen is on the right. Notice the Non Ciliated long, skinny cells, with nuclei at their base, lined up like dominoes in single file. The large clear spaces are goblet cells, which produce mucous for lubrication of the intestinal lining. 4. This is an oil-immersion (1000 X) view of a section of the large intestine. Individual columnar cells are clearly seen. In addition, the goblet cells are especially prominent. At this power, it is easier to see the microvilli of the brush border.

LARGE INTESTINE SMALL INTESTINE GI TRACT LARGE INTESTINE http://kcfac.kilgore.cc.tx.us/kcap1/images/simple%20columnar http://kcfac.kilgore.cc.tx.us/kcap1/images/simple%20columnar http://www.cedarville.edu/academics/sciencemath/sullivan/his http://www.cedarville.edu/academics/sciencemath/sullivan/his %20nonciliatd%20400x%20d%20fireworks.jpg %20nonciliated%20400x%20a%20fireworks.jpg tology/epithelia/simpcolhi.jpg tology/epithelia/simpcoloil.jpg 1. The cells on the surface of stratified squamous keratinized epithelium are very flat. Not only are they flat, but they are no longer alive. They have no nucleus or organelles. They are filled with a protein called , which is what makes our skin waterproof. The arrow at the top of the image is pointing to a keratinized cell that has partially separated from the rest of the Stratified Squamous Keratinized skin. These dead cells are continually lost from the surface of the skin, and are replaced by new cells from the layers below. 2. This high magnification image of the section from a thin skin shows the keratinized stratified squamous epithelium that makes up the epidermis and the underlying dermis of dense, irregular collagenous connective tissue. The portion of this epithelium closest to the dermis is composed of a living cells, which have with nuclei and basophilic cytoplasm. The outer portion is composed of PALM SKIN SKIN RUMINANT STOMACH http://www.austincc.edu/histologyhelp/tissues/images/tg400co http://casweb.ou.edu/pbell/Histology/Images/Slides/Epitheliu http://cal.vet.upenn.edu/projects/histo/Lab14stomach/Lab14a http://faculty.une.edu/com/abell/histo/StrSqKerEpiw.jpg mbo.jpg m/61.thin.skin.epi.40.jpg s48rumen40x.htm

1.Human esophagus cross section is lined with non-keratinize. 2. This image is labeled with free edge, basement membrane and connective tissue. 3. All the squamous cell out to the surface have nuclei 4. Note that the cervical glands are wide, numerous, and branching. The glands are lined by Non Keratinized simple columnar epithelium. The cervical canal is lined also by simple columnar epithelium. This epithelium abruptly changes to nonkeratinized stratified squamous epithelium near the external os. Note on the vaginal side of the slide there is an absence of glands but many veins.

ESOPHAGUS ESOPHAGUS CORNEA CERVIX http://kcfac.kilgore.cc.tx.us/kcap1/images/stratified%20squamo http://faculty.une.edu/com/abell/histo/strsque.gif http://faculty.une.edu/com/abell/histo/nonkstrsqw.jpg http://www.ouhsc.edu/histology/Glass%20slides/22_04.jpg us%20400x%20b%20fireworks.jpg

1. Cross-sectional view through a duct of a sweat gland illustrating stratified cuboidal epithelium. 2. Stratified cuboidal epithelium lines the ducts of sweat glands. 3. In which, more than one layer of cuboidal cells are found arranged on a basement membrane. It occurs in some parts of the reproductive system, ducts of sweat glands and in the lining of the pharynx. 4. Two Cuboidal adjacent seminiferous tubules, separated by connective tissue (CT), are present in the image. The germinal epithelium is composed of stratified cuboidal cells in various stages of spermatogenesis. Spermatozoa (Sz) are vaguely visible in the tubule lumens.

SWEAT DUCT SWEAT GLAND REPRODUCTIVE SYSTEM SEMINIFEROUS TUBULE http://www.kumc.edu/instruction/medicine/anatomy/histoweb/ http://www.kumc.edu/instruction/medicine/anatomy/histoweb/ http://image.tutorvista.com/content/animal-histology/stratified- http://www.bioimagingllc.com/images/04%20Testis%20Semi epithel/small/Epth017s.JPG epithel/small/Epth016s.JPG cuboidal-epithelium.jpeg niferous%20Tubules%20100X.jpg 1. Stratified Columnar epithelium is rare. One place you can find it is in the largest ducts of salivary glands. The basal layer of cells are cuboidal cells and the layer nearest the apical surface includes columnar cells. The large droplets are mucus, in Goblet cells. 2. A large submaxillary gland is labeled with yellow arrow. 3.A double layer of stratified columnar cells enclose the Columnar lumen of a salivary duct in the submandibular gland. Even though the plasma membranes of the cells are obscure, the cells can be identified as being columnar because the nuclei are located at the base of the cells. The duct is surrounded by connective tissue (CT) in which darkly stained fibroblast (Fb) nuclei can be seen. 4, This image is labeled with Lumen and goblet cell

SALIVARY GLAND SUBMAXILLARY GLAND SALIVARY DUCT SUBMAXILLARY GLAND http://www.cytochemistry.net/microanatomy/epithelia/salivary http://www.bioimagingllc.com/images/02%20Submandibular http://kcfac.kilgore.cc.tx.us/kcap1/images/stratified%20column http://www.ouhsc.edu/histology/Glass%20slides/47_02.jpg 8.jpg %20Gland%20%20400X.jpg ar%20400x%20b%20fireworks.jpg

1. Transitional Epithelial cells can slide by one another allowing the epithelium to get thinner (as in a full bladder) without losing the ability to form a strong layer. 2. Two diagnostic characteristics are: luminal cells -are Transitional sometimes binucleate and "balloon" out into the lumen giving an uneven appearance to the luminal surface.3. This image is labeled with connective tissue, blood vessel and lumen 4.a collapsed layers of the transitional cells, b. surface of the collapsed ureter.

URINARY BLADDER URETER KIDNEY URETER http://upload.wikimedia.org/wikipedia/commons/thumb/9/91/H http://kcfac.kilgore.cc.tx.us/kcap1/images/stratified%20transitio http://faculty.une.edu/com/abell/histo/transep.gif http://nhscience.lonestar.edu/bioL/tissue/transhi.jpg arnblase_Urothel.png/632px-Harnblase_Urothel.png nal%20400x%20b%20fireworks.jpg

1. Pseudostratified columnar epithelium is made up of one layer of columnar cells which frequently look like multiple layers. 2. (A)This tissue all begin at the basement membrane, only a few reach the surface. (B): cilia are easily seen on the surface. (C): the nuclei appear at various levels giving the tissue Pseudostratified a stratified appearance. FUNCTION: Secretion and movement of mucus by ciliary action 3. Not a true stratified tissue, nuclei of cells are at different levels, all cells are attached to basement membrane but not all reach the apical surface. 4. This image are labeled with cilia, basement membrane, goblet cell and hyaline cartilage.

AIRWAY OF UPPER RESPIRATORY TRACT TRACHEA RESPIRATORY TRACT TRACHEA

http://www.lima.ohio- http://kcfac.kilgore.cc.tx.us/kcap1/images/pseudostratified%20 http://www.unomaha.edu/hpa/images/1pseudostr.jpg http://www4.napavalley.edu/Projects/1799/3_Pseudostratified_100x.jpg state.edu/biology/images/anatomy/Pseudosratified%20colum columnar%20cilated%20400x%20b%20fireworks.jpg