nanomaterials Review Nanoengineering in Cardiac Regeneration: Looking Back and Going Forward 1 2 2, 2, , Caterina Cristallini , Emanuela Vitale , Claudia Giachino y and Raffaella Rastaldo * y 1 Institute for Chemical and Physical Processes, IPCF ss Pisa, Italian National Research Council (CNR), 56126 Pisa, Italy;
[email protected] 2 Department of Clinical and Biological Sciences, University of Torino, 10043 Orbassano, Torino, Italy;
[email protected] (E.V.);
[email protected] (C.G.) * Correspondence: raff
[email protected] These authors contributed equally to this work. y Received: 4 June 2020; Accepted: 10 August 2020; Published: 12 August 2020 Abstract: To deliver on the promise of cardiac regeneration, an integration process between an emerging field, nanomedicine, and a more consolidated one, tissue engineering, has begun. Our work aims at summarizing some of the most relevant prevailing cases of nanotechnological approaches applied to tissue engineering with a specific interest in cardiac regenerative medicine, as well as delineating some of the most compelling forthcoming orientations. Specifically, this review starts with a brief statement on the relevant clinical need, and then debates how nanotechnology can be combined with tissue engineering in the scope of mimicking a complex tissue like the myocardium and its natural extracellular matrix (ECM). The interaction of relevant stem, precursor, and differentiated cardiac cells with nanoengineered scaffolds is thoroughly presented. Another correspondingly