FEATURE Variations in reproductive and developmental toxicant identification

An important function for safety professionals is the identification of reproductive toxicants. This manu- script will provide an overview of what reproductive toxicants are and difficulties associated with determin- ing what chemicals should be considered reproductive toxicants. It will also review sources used to help with reproductive toxicant determinations and demonstrate limitations in using these sources. A table of 934 chemicals combined from six databases: California Proposition 65, Reprotext, ACGIH, Hax-Map, Navy and Marine Corps Public Health Center Technical Manual, and a list published by Jankovic and Drake is presented. Only four of these chemicals were listed in all six sources.

By David Quigley, safety professionals do not have the in- tion, etc. The definition from OSHA’s Fred Simmons, depth knowledge of toxicology to fully Hazard Communication Standard and Helena Whyte, understand the subject. In this paper Laboratory Standard states that a Janeen Robertson, we will provide an overview of what reproductive toxin is anything that David Freshwater reproductive toxicants are, why they can affect reproductive capabilities are important, difficulties with their and fetus development and includes identification, and methods the health teratogens.2,3 Others, such as Casarett and safety professional can use to aid and Doull’s Toxicology,4 limit the scope INTRODUCTION in their identification. of the definition to exclude develop- mental effects. Since OSHA requires An important function for the health reproductive toxicants to be specially and safety professional is to protect the REPRODUCTIVE TOXICANTS—WHAT managed as ‘‘particularly hazardous employee from reproductive toxicants. ARE THEY AND WHY ARE THEY substances’’,3 this paper shall use the The difficulty that arises from this IMPORTANT? more broad definition that includes responsibility is that the science of developmental as well as the more strin- reproductive toxicant identification is The first question that needs to be gently defined reproductive toxicants. so complex that it sometimes appears answered is ‘‘What is a reproductive Reproductive toxicants are impor- contradictory and that most health and toxin?’’ The answer varies. A reproduc- tant from several aspects. From a tive toxicant is any agent that causes an worker protection perspective, repro- David Quigley is affiliated with the Y- adverse effect on the reproductive abil- ductive toxicants are important because 12 National Security Complex, Oak ity of an organism, but the scope defini- each worker needs to be able to protect Ridge, TN, United States. tion is subject to interpretation. The their offspring from deleterious chemi- Registry of Toxic Effects of Chemical cal effects. While protecting employees 1 Fred Simmons is affiliated with the Substances (RTECS) identifies seven from reproductive toxicants is not only Savannah River Nuclear Solutions major categories of reproductive toxi- of ethical importance, it is also required LLC, Aiken, SC, United States. cants. These major categories are those by OSHA. 29CFR1910.1200, Hazard that cause adverse paternal effects, Communication, is the OSHA standard Helena Whyte is affiliated with the Los maternal effects, effects on fertility, that applies to non-laboratory workers Alamos National Laboratory, Los Ala- effects on embryo or fetus, developmen- and most production and manufactur- mos, NM, United States (e-mail: moz- tal changes, tumorgenic effects and ing laboratory workers. This standard [email protected]). effects upon the newborn organism. requires that the employer inform Within these seven major categories workers of hazards in the workplace Janeen Robertson is affiliated with the are 65 specific effects such as poor and then take measures to protect Lawrence Livermore National Labora- sperm production or motility, altered the workers from those hazards. Repro- tory, Livermore, CA, United States. ovulation cycle, altered hormone levels, ductive toxicants are one hazard altered gestation period, difficulties in specifically identified in the standard David Freshwater is affiliated with the egg implantation, low birth weight, from which the employer needs to pro- U.S. Department of Energy/NNSA, abnormally slow development, reduced tect the employee. 29CFR1910.1450, Washington, DC, United States. postnatal survival, spontaneous abor- Occupational Exposure to Hazardous

1871-5532/$36.00 ß Division of Chemical Health and Safety of the American Chemical Society 29 doi:10.1016/j.jchas.2009.04.001 Elsevier Inc. All rights reserved. Chemicals in the Laboratory, is the The definition of ‘‘carcinogen’’ differs not all species respond to toxicants OSHA standard that protects most from that of ‘‘toxic’’ in that carcinogeni- similarly. Taken together, these issues laboratory workers (e.g. research and city is almost always based upon make the absolute determination of academic laboratory workers). This chronic exposures. Once a population reproductive toxicity difficult. standard identifies reproductive toxi- is exposed to a chemical product, then it cants as being a ‘‘particularly hazardous is declared a ‘‘carcinogen’’ when can- substance’’ (PHS). Whenever a chemi- cerous tissue appears at a statistically SOURCES FOR REPRODUCTIVE cal is designated as being a PHS, reg- significant increased rate in the popula- TOXIN DETERMINATIONS ulations require the use of special tion. Because determinations of carci- controls to protect the worker. These nogens are based upon a chronic Many sources exist to help the health controls can be expensive to implement exposure, no exposure levels are used and safety professional with the deter- and can consume limited resources so to determine the equivalent of an LD50 mination as to whether or not a che- the proper identification of reproduc- or LC50 dose or concentration. What mical or chemical product is a tive toxicants is important from a makes the determination of carcino- reproductive toxin. The use of each resource loading perspective. genicity more precise is that the concept has its advantages and disadvantages. of ‘‘statistically significant’’ is defined. If the rate of cancer formation upon expo- Material Data Safety Sheet (MSDS) DIFFICULTIES IN REPRODUCTIVE sure to a chemical agent is below the The Hazard Communication Standard TOXIN DETERMINATION defined statistically significant rate, (29CFR 1910.1200) requires the man- then the chemical product is not con- ufacturer or importer to perform a There are many difficulties associated sidered to be a ‘‘carcinogen’’. If the rate hazard determination for all chemicals with determining if a product is a of cancers is greater than the statisti- or chemical products they manufac- reproductive toxin. The most signifi- cally significant rate, then the chemical turer or import. These hazards are then cant problem is that, due to the com- product is defined as a ‘‘carcinogen’’. required to be listed on the Material plex nature of the science such as the Many issues are at play which makes Safety Data Sheet (MSDS). If the wide variety of potential reproductive reproductive toxin determinations dif- employer does not wish to perform a effects described above or the absence ficult. First is the method of exposure. hazard determination on his own, then of a clear endpoint described below, Reproductive toxicants can be caused he is required to use the hazard deter- there are no universally accepted by either an acute (usually less than mination information on the manufac- methods for determining reproductive 24 h), subacute (typically less than 1 turer’s MSDS. Since reproductive toxicity. The easiest way to explain this month), subchronic (typically 1–3 toxicity is a hazard required to be listed difficulty is to compare the definition month) or by chronic (typically more on the MSDS, the MSDS becomes a of ‘‘reproductive toxin’’ to the defini- than 3 months) exposures and the primary source for the employer to use tion of ‘‘toxic’’ and the definition of effects of these exposures can be further in determining if a product is a repro- ‘‘carcinogen’’. affected by the concentration of the ductive toxicant. Sometimes the MSDS A well-known tenet of toxicology is toxicant, the route of exposure, and will simply state that the product is a that everything will be toxic when an the point in the reproductive cycle that reproductive toxin which makes the organism is exposed to a large enough the exposure occurs. Because LD50 or determination easy. Some MSDSs will concentration in a single acute dose. LC50 values are based upon acute expo- state that the product is a teratogen or Because of this principle, numerous sures, none can be assigned here due to mutagen (which can sometimes be regulatory agencies such as OSHA these issues. Second, reproductive tox- classed as a reproductive toxin), but will have made definitions of ‘‘toxic’’ based icants do not always result in a clear remain silent on the reproductive toxin upon the LD50 or LC50 values for the endpoint. Some potential effects such issue. In these cases the determination product. (The LD50 is the dose and the as low birth weight are statistical events is again easy since teratogens and some LC50 is the airborne concentration that require a clear definition of ‘‘low mutagens are a subclass of reproductive required to kill 50% of a test popula- birth weight’’. What are not always toxicants which would cause any pro- tion.) OSHA, for example, defines defined are issues such as when a birth duct to be classed as a teratogen to be a ‘‘toxic’’ as the LD50 for ingestion of weight is considered to be abnormally reproductive toxin. A large number of 500 mg/kg. Any product with a smaller low. Third, the statistical significance of MSDSs, however, will either state that LD50 is considered to fit the definition event frequency is not always defined. the product may be a reproductive toxin of ‘‘toxic’’ and products with a LD50 Fourth is the complex nature of repro- or will say nothing about the product’s greater are not considered to fit this duction. Sexual reproduction requires reproductive toxicity. In these cases definition.1,2 Having this definition two sexes and numerous organ systems further research may be required to makes it easy to identify those products to function. These are, in turn, con- make an accurate determination. that are ‘‘toxic’’ and those that are not trolled by hormones and emotions ‘‘toxic’’. But what also makes this defi- which can complicate measurements Registry of Toxic Effects of Chemical nition appropriate is that the definition by increasing confounding factors. Substances (RTECS)1 uses a well-defined endpoint based Lastly, many species can be used to The Registry of Toxic Effects of Che- upon a single acute exposure. determine reproductive toxicity, but mical Substances is a publication of the

30 Journal of Chemical Health & Safety, January/February 2010 National Institute for Occupational and mercury compounds. A concern for each chemical so the health and Safety and Health (NIOSH) and is a that could be raised about using the safety professional must make up their compendium of toxicological data California Proposition 65 list is that a mind as to whether or not the chemical extracted from the scientific literature. large majority of reproductive toxins in question is a reproductive toxin. Reproductive effects data are included listed are pharmaceutical chemicals in each chemical listing. The primary which might not be of significance to Development and Reproductive 9 advantage of RTECS is that it provides those working in most industries. Toxicology (DART) Database the most complete listing of chemicals While the process to add a chemical The Development and Reproductive that have been tested for potential to California Proposition 65 is well Toxicology Database is maintained reproductive effects. The primary dis- documented, the criteria used to deter- by the United States National Library advantage and a commonly misunder- mine if a chemical or class of chemicals of Medicine. It is a listing of articles stood point of RTECS is that it simply is on the list is not described. concerning reproductive toxicology provides a listing of what studies were that can be searched by topic. This 1 performed and a synopsis of the stu- Reprotext 7 database has the weakness of primarily 1 dies’ data. It does not provide any Reprotext is a data listing published being a tool for researchers who are information concerning significance by Thompson Micromedex that lists investigating reproductive toxicants. of the data nor does it make any judg- reproductive toxicants. This listing When a chemical is identified using ments concerning the studies’ results. not only lists chemicals that have been this tool, it retrieves a listing of journal In other words, RTECS simply states tested for potential reproductive article citations that discuss the che- what studies were performed and what health effects, but it also provides rank- mical. In addition to the journal cita- the results were; it does not determine ings, as determined by the company’s tion, the database will also display the or classify chemicals to be reproduc- committee of experts, on the relative first 250 words of the article’s abstract tive toxicants nor does it attempt to degree of the reproductive toxicity. to give the reader an idea as to the determine the degree of reproductive Ratings include known and uncon- paper’s contents. This resource pro- toxicity. firmed human reproductive toxin vides little help for the health and (rated ‘‘A’’), known animal reproduc- safety professional attempting to deter- Catalog of teratogenic agents5 tive toxicants (rated ‘‘B’’), no data mine if a chemical should be classified The Catalog of teratogenic agents is an available (rated ‘‘C’’), insufficient data as a reproductive toxin since it only excellent source of information con- available (rated ‘‘D’’) and not thought lists research articles with a portion of cerning teratogenic agents. It is similar to be a reproductive toxin (rated ‘‘E’’). the articles’ abstract. to RTECS in that it provides a listing of The focus of this listing is those che- 10 chemicals that have been tested for micals that could pose a threat to a Jankovic and Drake producing teratogenic effects, but it worker. Criteria used to determine if In 1996, Jankovic and Drake devel- suffers from two limitations. The first a chemical is deemed to be a reproduc- oped a method for determining limitation is that, like RTECS, it pro- tive toxicant or the degree of reproduc- whether or not a product was consid- vides only the data and does not pro- tive hazard is not described. ered to be a potential reproductive vide an interpretation as to whether or health hazard and what exposure lim- not the teratogenic effects of a chemi- Center for the Evaluation of Risks to its should be set to protect workers 8 cal are significant or not. Second, it Human Reproduction (CERHR) from these hazards. This method provides only a listing for teratogens The Center for the Evaluation of Risks involved initially identifying reproduc- which is a subset of all reproductive to Human Reproduction was char- tive toxicant candidates by searching toxicants. tered by the National Toxicology Pro- RTECS for chemicals that demon- gram and the National Institute of strated at least one positive reproduc- California Proposition 656 Environmental Health Sciences in tive effect. Initially identified In 1986 voters in California approved 1998. Since its inception CERHR has candidates were then culled for those Proposition 65 which required Califor- evaluated approximately 25 chemicals chemicals that showed a positive nia to publish annually a list of chemi- for reproductive toxicity. Each evalua- reproductive outcome for multiple cals that could cause cancer, birth tion is published as a monograph and mammalian species and then culled defects and other reproductive harm these monographs vary from 100 to further to only include what they con- in an effort to protect the citizens of several hundred pages in length. The sidered to be occupationally important that state from chemical exposures. monographs present an exhaustive chemicals. One weakness to this The most current list is approximately treatment of each investigated chemi- approach is that it ignores potential 250 entries long and contains all che- cal and provides a degree of risk asso- reproductive toxicants that have only micals thought to be reproductive tox- ciated with the subject chemical. For been identified by positive results in icants by the state of California. Also, the purposes of this manuscript, one one species while another weakness several entries on the list are not indi- weakness in this database is that there is that it eliminates substances that vidual chemicals but are instead are so few chemicals that have been could be used medicinally which could classes of compounds such as barbitu- analyzed. Another weakness is that be important to those working in phar- rates, benzodiazepines, tetracyclines, varying levels of concern are provided maceutical and related industries.

Journal of Chemical Health & Safety, January/February 2010 31 Using this method, they identified 213 Scorecard13 have been used successfully to predict chemicals that should be considered Other sources and methods may be biological activities such as receptor potential reproductive health hazards used to help determine if a chemical based drug design.15,16 While these and what ‘‘occupational exposure is a reproductive toxicant. One source tools are widely used in the pharma- guidelines’’ should be set for each. is Scorecard. Scorecard is a resource ceutical industry to predict which ana- developed by the advocacy group, logs of a particular drug warrants American Conference of Governmental Environmental Defense Fund, that further investigation, they are not 1 11 Industrial Hygienists (ACGIH ) provides the public with information widely used in general industry 1 ACGIH annually publishes Thresh- about chemicals pollutants in the because of the cost and availability of 1 old Limit Values (TLVs ) and Biolo- environment. Scorecard provides quality data for modeling. For exam- 1 gical Exposure Indices (BEIs ) numerous links to sites that identify ple, Matthews, et al.17 constructed a which lists exposure limits that are reproductive toxicants and provides database using more than 10,000 indi- established by committees that review their own list of ‘‘recognized’’ and vidual rat, mouse, or rabbit reproduc- existing published and peer-reviewed ‘‘suspected’’ reproductive toxicants. tive toxicity tests which were literature in various scientific disci- The list provided by Scorecard is based associated with 2134 different organic plines. One data element published upon many of the sources cited above structures. These data were divided 1 by ACGIH is ‘‘TLV Basis’’. The data but does not include privately funded into classes such as male reproductive shows only the primary or critical sources such as ACGIH or Repro- toxin, female reproductive toxin, etc. 1 health effect that supports the deriva- text . Along with this analysis, 90 categories tion of the TLV. Other health effects were defined each consisting of over are not listed. If the ACGIH identifies Navy and Marine Corps Public Health 500 chemicals. The model showed that the chemical to be listed as having a Center Technical Manual14 clusters of specific categories con- critical health effect on the reproduc- This manual is a guidance document tained chemicals that were active in tive system, or embryo/fetus in the from the United States Navy and Mar- more than one species and therefore 1 ‘‘TLV Basis’’ column, then the che- ine Corps and provides an extensive may be expected to have the highest mical should be considered as a listing of reproductive toxicants in one risk to humans. reproductive toxin. The limitation to table and developmental toxicants in In a companion article,18 Matthews, this resource is that only a very few another table. It is heavily annotated to et al. constructed and tested several chemicals are identified as having describe the exact nature of the toxic models to predict the hazards of reproductive toxicity as a critical effect and the source(s) of the informa- untested chemicals. There were seven health effect. If a chemical is a repro- tion. Selection criteria for screening classes tested. The QSARs used weight ductive toxin, but the reproductive toxicants are not described in this of evidence paradigm using rat, mice toxicity is not the critical health document. Instead, this manual simply and rabbit study data to identify trans- effect, it will not be listed as a repro- states that it is a listing of ‘‘known’’ species toxicants. They concluded that ductive toxin. This means that many toxicants culled from lists such as Cali- their models had high specificity and chemicals that are reproductive tox- fornia Proposition 65 and then ‘‘objec- low false positives and had a wide ins will not be listed in the ACGIH tive criteria’’ are used to add to or applicability domain for FDA-regu- Booklet as reproductive toxins remove agents from the list. No state- lated organic chemicals. because reproductive toxicity is not ment is made as to what these ‘‘objec- The downside is that these data are the critical health effect. For example, tive criteria’’ are. This listing has statistically derived values; therefore the critical health effect for 1-chloro- several strong points including being false correlations are possible. Due to 2-propanol is liver damage, so it is not heavily referenced to clarify specific the complicated nature of determining listed as a reproductive toxicant in the toxic effects expected to be observed reproductive toxicants and variables in ACGIH Booklet. and cross-listing between chemical QSAR determinations, it is difficult for and trade names. It also provides good non-specialists to use these types of 12 Haz-Map information on how to manage these computations to determine which che- Haz-Map is a database provided by the toxicants. A potential weakness is that micals might be reproductive toxi- National Library of Medicine via the lists provided in this publication are cants. National Institute of Health that sup- heavily weighted towards pharmaceu- plies the public with information con- ticals. cerning the effects of occupational DIFFICULTIES IN USING exposures to hazardous materials. It Quantitative Structure Activity REPRODUCTIVE TOXIN SOURCES lists 136 chemicals, chemical classes Relationship (QSAR) Methodologies and physical hazards that are repro- Also known as quantitative structure– Initially, it would appear that an easy ductive hazards and provides links that property relationships (QSPR), QSAR method of identifying reproductive allows one to gain access to more based programs utilize electronic and toxicants would be to simply use either information about each identified lipophilicity properties of molecules the MSDS for the product in question hazard. Criteria used to determine if to predict biological activities. These or one of the databases cited above. a hazard is on the list are not described. computational chemistry methods While the use of the MSDS is appro-

32 Journal of Chemical Health & Safety, January/February 2010 priate and required, the health and is that diverging selection and evalua- tion is complete. If the MSDS does safety professional may choose to use tion criteria were likely used to gen- not state that the product is a repro- one of the above listed databases to erate each listing. Diverging selection ductive toxin or suggests that the help identify reproductive toxicants. and evaluation criteria would likely product might be a reproductive The use of these databases, however, be a natural outcome from the com- toxin, then one should consult is more difficult than one may first plexities associated with reproductive reproductive toxicant databases. realize. To illustrate this difficulty, six toxicant identification described above. 2. Use multiple databases databases, California Proposition 65,6 The most significant lesson to be If the MSDS does not provide 1 Reprotext (using chemicals rated ‘‘A’’ learned from these different reproduc- adequate information on a chemi- and ‘‘B’’),7 ACGIH,11 Haz-Map,12 the tive toxin lists is not why they may differ, cal’s reproductive toxicity, then one 1 11 Navy and Marine Corps Public Health but that they do differ. Because there is should consider using ACGIH , 6 Center Technical Manual,14 and the so little overlap between these lists, the California Proposition 65, Repro- 1 7 10 list published by Jankovic and Drake,10 use of a single-list based approach must text , Jankovic and Drake, and, 8 were combined into one listing be questioned. Without knowing and possibly, CERHR. If one chooses (Table 1, Alphabetical Combined List- approving the selection or evaluation to use chemicals identified in 8 ing of Reproductive Toxicants and criteria used to generate a reproductive CERHR, one would have to per- Table 2, Combined Listing of Repro- toxicant list, one cannot justify using form a bit of reading to determine if ductive Toxicants by CAS Number). (It one list over another. Likewise, if one the chemical should go into their 17 should be noted that CERHR chemi- looks to use a list to assist in determin- listing. Similarly, since Reprotext cals were not included on this com- ing those chemicals that are reproduc- uses a grading system for evaluating bined listing since CERHR provides a tive toxicants, then that suggests one reproductive toxicants, one could general level of concern and does not does not have sufficient knowledge to simply choose a rating and if the state which chemicals are considered a make the determination without out- chemical is rated above that level, reproductive toxin. DART chemicals side help. This being the case, one does then it would be considered to be a were also left off this list for similar not have the knowledge to claim that reproductive toxin. Chemicals 1 11 reasons. Scorecard was also not one reproductive toxin list is superior to listed in ACGIH , Jankovic and 10 included since many of those chemi- another list and each list must be treated Drake, and those identified in 17 cals listed in this database were derived with equal weight. Reprotext could be added to the from those lists cited above.) listing from California Proposition 6 In this table of reproductive toxi- 65 to provide for the final list as cants combined from these six RECOMMENDED PATH FORWARD was done in Table 1. Table 2 is the sources, there are 934 chemicals or same table sorted by CAS number. mixtures listed. Of these 934 items, The question is ‘‘How does one make 3. Be wary of mixtures 209 (22.4%) are listed in two sources, this reproductive toxicant determina- When identifying reproductive 49 (5.3%) are listed by three sources, tion given the complicated nature of toxicants in mixtures, the initial 29 (3.1%) are listed by four sources, the subject and the limited resources inclination is to use the rule from 13 (1.4%) were listed in five sources that are typically available to the the 29CFR1910.1200, Hazard Com- and 4 (0.4%) were listed in all six health and safety professional?’’ munication, to determine if a hazard sources. This results in 603 (67.5%) Clearly, determining what chemicals is present. This rule states that if the specific chemicals that are listed in or chemical products that should be mixture contains at least 1% of the only one source. (Percentages are considered as being a reproductive chemical (0.1% for carcinogens), approximate due to variations on toxicant is a difficult task. What is then the mixture contains the how chemicals are listed by various needed is a simplified approach to help hazard. Attempting to apply this rule organizations.) Two inferences can be with this determination for health and to reproductive toxicants may not be drawn from this. First, there appears safety professionals who are not toxi- appropriate. For example, oxygen at to be differing intents which lead to cologists and do not have access to a 100% concentration is a reproduc- differing starting lists used for repro- people with toxicology expertise. tive toxin to fetuses and newborn ductive toxin determinations. For There are several steps one can take infants. If one were to blindly apply example, the list found in California to accomplish this task. the 1% rule, then this would result in Proposition 65 appears to contain far air, which contains 21% oxygen, more pharmaceuticals than any of the 1. Use the MSDS being a reproductive toxin. Other, other lists. Using a different set of Regulations require that an similar examples are easy to find. assumptions for which chemicals MSDS for every chemical or chemi- should be analyzed will also serve cal product be present and that the CONCLUSIONS to prejudice the information. For MSDS be used to determine example two classic reproductive tox- hazards for employee training and Accurate determination of reproduc- icants, thalidomide and ethanol were information. If the MSDS states the tive toxicants is important to both pro- only listed in three and four of the six product to be a teratogen or a repro- tect the worker and to ensure lists, respectively. A second inference ductive toxin then the determina- that limited resources are not con-

Journal of Chemical Health & Safety, January/February 2010 33 sumed unnecessarily. To accomplish 5. Shepard, T. H. Catalog of Teratogenic Corps Public Health Center Technical this task, one must first understand Agents, 12th edition Johns Hopkins Manual NEHC-TM-OEM 6260.01B the difficulties in making reproductive University Press; Baltimore MD, 2007. July 2008. toxin determinations and then develop 6. California Proposition 65, http:// 15. An Introduction to QSAR Methodol- www.oehha.ca.gov/prop65.html. ogy, Network Science Corpora- a strategy that will make use of avail- 7. Reprotext, http://csi.micromedex.- tion1116 Miller Mountain Road able information in a constructive com/X/Rera.htm. Saluda, NC 28773-8677, http:// organized manner. For most health 8. Center for the Evaluation of Risks to www.netsci.org/Science/Compchem/ and safety professionals, this strategy Human Reproduction, http://cerhr.- feature19.html, October, 1997. should be to first rely upon information niehs.nih.gov/index.html. 16. Hansch, C.; Leo, A. Exploring QSAR: found in the MSDS and, if insufficient 9. Development and Reproductive Toxi- fundamentals and applications in information is present to make that cology Database, http://toxnet.nlm.- chemistry and biology. Am. Chem. determination, then multiple data- nih.gov/cgi-bin/sis/htmlgen?DARTE- Soc. 1995,. bases should be used. TIC. 17. Matthews, E. J.; Kruhlak, N. L.; Benz, 10. Jankovic, J.; Drake, F. A screening R. D.; Contrera, J. F. A comprehensive method for occupational reproductive model for reproductive and develop- REFERENCES health risk. Am. Ind. Hyg. Assoc. J. mental toxicity hazard identification. 1. Registry of Toxic Effects of Chemical 1996, 57(7), 641–649. I. Development of a weight of evi- Substances (RTECS)—Comprehensive 11. ACGIH. Documentation of the dence QSAR database. Regulat. Guide to the RTECS, DHHS (NIOSH) Threshold Limit Values and Biologi- Toxicol. Pharmacol. 2007, 47,115– Publication No. 97-119, 1997. cal Exposure Indices, 7th edition 135. 2. 29CFR1910.1200, Hazard Communi- American Conference of Governmen- 18. Matthews, E. J.; Kruhlak, N. L.; Benz, cation, Appendix A. tal Industrial Hygienists; Cincinnati, R. D.; Ivanov, J.; Klopman, G.; Con- 3. 29CFR1910.1450, Occupational Expo- OH, 2008. trera, J. F. A comprehensive model for sures to Hazardous Chemicals in the 12. Haz-Map, http://hazmap.nlm.nih.gov/ reproductive and developmental toxi- Laboratory. hazmapadv.html. city hazard identification. II. Construc- 4. Klaassen, C. D. (Ed.). (1996). Casarett 13. Scorecard, http://www.scorecard.org/. tion of QSAR models to predict & Doull’s Toxicology, (pp. 547–581). 14. Reproductive and Developmental Ha- activities of untested chemicals. Regu- (5th edition). McGraw-Hill, 1996p. zards: A Guide for Occupational lat. Toxicol. Pharmacol. 2007, 47, 136– 547–581. Health Professionals, Navy and Marine 155.

Table 1. Alphabetical Combined Listing of Reproductive Toxicants. This is a listing of chemical reproductive toxicants taken from California Proposition 65,6 Reprotext1 (using chemicals rated ‘‘A’’, known and unconfirmed human reproductive toxicants, and ‘‘B’’, known animal reproductive toxicants),7 Jankovic and Drake,10 ACGIH,11 Haz-Map,12 and the Navy and Marine Corps Public Health Center Technical Manual.14 NA indicates that the product listed is either a mixture, chemical class or that there was not enough information present to assign a CASRN. Chemical name CAS #a Ref.b Chemical name CAS #a Ref.b Acephate 30560-19-1 7 1-Hexene 592-41-6 12 Acetaldehyde 75-07-0 7,10,14 2-Hexanone 591-78-6 11,12 Acetazolamide 59-66-5 6 Histrelin acetate 76712-82-8 6,14 Acetic acid 64-19-7 7 Hydramethylnon 67485-29-4 6 Acetohydroxamic acid 546-88-3 6,7,14 Hydrazine 302-01-2 7,10,12 Acetone 67-64-1 7 Hydriodic acid 10034-85-2 14 Acetone cyanohydrin 75-86-5 7 Hydrofluoric acid 7664-39-3 7 Acetone thiosemicarbazide 1752-30-3 7 Hydrofluorosilicic acid 16961-83-4 7 Acetonitrile 75-05-8 7,10,12 Hydrogen chloride 7647-01-0 7 Acetoxytriphenylstannane 900-95-9 7 Hydrogen cyanide 74-90-8 7 Acetylene 74-86-2 7 Hydrogen peroxide 7722-84-1 7 Acetylsalicylic acid 530-75-6 6,7,14 Hydrogen selenide 7783-07-5 7 Acitretin 55079-83-9 14 Hydrogen sulfide 7783-06-4 7 Acrolein 107-02-8 7,10 Hydroquinone 123-31-9 7 Acrylamide 79-06-1 7,10,12 Hydroxymethyl mercury 1184-57-2 10 Acrylic acid 79-10-7 7,12 Hydroxyprogesterone 68-96-2 14 Acrylonitrile 107-13-1 12 Hydroxyurea 127-07-1 6,14 Actinomycin D 50-76-0 6,7,14 Ibuprofen 15687-27-1 14 Activated carbon 7440-44-0 7 Idarubicin HCl 57852-57-0 6,14 Adiponitrile 111-69-3 7 Ifsoamide 3778-73-2 6,14 Aflatoxin-B 1162-65-8 10 3-Indoleacetic acid 87-51-4 10 Aldicarb 116-06-3 7 Indomethacin 53-86-1 14

34 Journal of Chemical Health & Safety, January/February 2010 Table 1 (Continued ) Chemical name CAS #a Ref.b Chemical name CAS #a Ref.b Aldrin 309-00-2 7,10 Iodinated glycerol 5634-39-9 14 (antitussive/expectorant) Alfentanil 71195-58-9 14 Iodine 7553-56-2 7,10,14 Alkyl dimethylbenzyl 8001-54-5 7 Isobutyl alcohol 78-83-1 7 ammonium chloride Allyl chloride 107-05-1 7,10 Isodrin 465-73-6 7 Alprazolam 28981-97-7 6,14 2-Isopropoxyethanol 109-59-1 12 Aluminum 7429-90-5 7 Isopropyl alcohol 67-63-0 7 Aluminum chloride 7446-70-0 10 Isotretinoin 4759-48-2 6,14 Aluminum oxide 1344-28-1 7 Jet fuel NA 7 Amanatadine HCl 665-66-7 6 Kanamycin 8063-07-8 14 Amikacin 37517-28-5 6,14 Kanechlor 500 61788-33-8 10 Aminoglutethimide 125-84-8 6,14 Kaolin 1332-58-7 7 Aminoglycosides NA 6 Kepone 143-50-0 6,10,12,14 Aminomesitylene 88-05-1 7 Kerosene 8008-20-6 7 Aminonicotinamide 329-89-5 10 Lactonitrile 78-97-7 7 3-Aminopropionitrile 151-18-8 10 Lead 7439-92-1 6,7,10,12,14 3-Aminopropionitrile fumarate 2079-89-2 10 Lead acetate 301-04-2 7,10 p-Aminopropiophenone 70-69-9 7 Lead arsenate 3687-31-8 12 Aminopterin 54-62-6 6,7,10,14 Lead carboxylate 68603-83-8 7 Amiodarone 19774-82-4 6,14 Lead chromate 7758-97-6 7,11,12 Amiodarone HCl 19774-82-4 14 Lead diamyldithiocarbamate 36501-84-5 7 Amitraz 33089-61-1 6 Lead II thiocyanate 592-87-0 12 Amitrol 61-82-5 10,12 Lead naphthalene 61790-14-5 7 Amitryptyline 549-18-8 14 Lead nitrate 10099-74-8 7 Ammonia 7664-41-7 7 Lead oxide 1309-60-0 7 1314-41-6 1317-36-8 Ammonium bisulfite 10192-30-0 7 Lead, inorganic compounds NA 6 Ammonium chloride 12125-02-9 7 Leptophos 21609-90-5 7 Ammonium hydroxide 1336-21-6 7 Leuprolide 74381-53-6 6,14 Ammonium nitrate 6484-52-2 7 Levodopa 59-92-7 6 Ammonium silicofluoride 16919-19-0 7 Levofloxacin 100986-85-4 14 Ammonium sulfate 7783-20-2 7 Lewisite 541-25-3 7,10 Amoxapine 14028-44-5 6 Light ends (liquid) NA 7 Amphetamines NA 14 Limonene 5989-27-5 7 Amudane 126-07-8 10 Lindane 58-89-9 7,10 Amyl acetate 628-63-7 7 Linuron 330-55-2 6 tert-Amyl methyl ether 994-05-8 11 Lisinopril 76547-98-3 14 Amyl nitrate 110-46-3 7 Lithium 7439-93-2 7,14 Anabolic steroids NA 6,14 Lithium carbonate 554-13-2 6,14 Anesthetic gases NA 14 Lithium chromate 14307-35-8 7 Angiotensin converting NA 6,14 Lithium citrate 919-16-4 6,14 enzyme inhibitors Aniline 62-53-3 7 Lithium hydroxide 1310-66-3 7 Anisindione 117-37-3 6,14 Lomefloxacin 98079-51-7 14 Antihistamines NA 14 Lomustine 13010-47-4 6,14 Antimony 7440-36-0 7 Lorazepam 846-49-1 6,14 Antimony pentafluoride 7783-70-2 7 Lovastatin 75330-75-5 6,14 Antimony potassium tartrate 64070-11-7 7 Magnesium nitrate 10377-60-3 7 Antioxidant 330 1709-70-2 7 Magnesium silicofluoride 18972-56-0 7 Aroclor 1016 12674-11-2 10 Malathion 121-75-5 7 Aroclor 1260 11096-82-5 10 Malononitrile 109-77-3 7 Arsenic 7440-38-2 7,10,12,14 Mancozeb 8018-01-7 12 Arsenic pentoxide 1303-28-2 6,7,12 Maneb 12427-38-2 10,12 Arsenic trichloride 7784-34-1 7,12 Manganese 7439-96-5 7,12

Journal of Chemical Health & Safety, January/February 2010 35 Table 1 (Continued ) Chemical name CAS #a Ref.b Chemical name CAS #a Ref.b Arsenic trioxide 1327-53-3 6,7,12 Manganese, inorganic NA 10 compounds Arsine 7784-42-1 7,12 Manganese dioxide 1313-13-9 7 Asbestos 1332-21-4 7 Manganese sulfate 7785-87-7 7 Atenolol 29122-68-7 6,14 Manganese tetroxide 1317-35-7 12 Atrazine 1912-24-9 10 Marijuana NA 14 Auranofin 34031-32-8 6 MCPP/2,4-D NA 7 Azathioprine 446-86-6 6,14 Mebendazole 31431-39-7 6 Azinphos methyl 86-50-0 7 Medroprogesterone acetate 71-58-9 6,14 Banazepril 86541-75-5 14 Megestrol acetate 595-33-5 6,14 Barbiturates NA 6,14 Melphalan 148-82-3 6,10,14 Barium chromate 10294-40-3 7 Menadione 58-27-5 14 Barium permanganate 7787-36-2 12 Menotropins 9002-68-0 6,14 Barium soluble salts NA 7 Mephobarbital 115-38-8 14 Beclomethasone dipropionate 5534-09-8 6 Meprobamate 57-53-4 6,14 Benomyl 17804-35-2 6,7,10–12 Mercaptopurine 6112-76-1 6,14 Bentazon 25057-89-0 7 Mercuric acetate 1600-27-7 6,7,14 Benzene 71-43-2 6,7,10,12,14 Mercuric chloride 7487-94-2 6,7,10,12,14 2-Benzimidazolecarbamic 10605-21-7 10 Mercuric iodide 7774-29–0 6,7,14,10 acid, methyl ester Benzo(a)pyrene 50-32-8 7,10 Mercuric nitrate 10045-94-0 6,10,12,14 Benzodiazepines NA 6,14 Mercuric oxide 21908-53-2 6,7,10,14 Benzoyl peroxide 94-36-0 7 Mercurous nitrate 10415-75-5 6,10,12,14 Benzphetamine HCl 5411-22-3 6,14 Mercury 7439-97-6 6,7,10,12,14 Benzyl alcohol 100-51-6 7 Mercury, alkyl compounds NA 10,12,14 Benzyl chloride 100-44-7 7 Mercury, aryl compounds NA 10,12,14 Beryllium 7440-41-7 7 Mercury, inorganic compounds NA 10,14 Betadine NA 14 Mestranol 72-33-3 14 Bis(2-chloroethyl)ethylamine 538-07-8 12 Methacycline 3963-95-9 6,14 Bischloroethyl nitrosourea 154-93-8 6,14 Metham sodium 137-42-8 6 Bismuth 7440-69-9 7 Methamidophos 10265-92-6 7 Bisphenol A 80-05-7 10 Methane 74-82-8 7 Bitoscanate 4044-65-9 7 Methanesulfonic acid 66-27-3 10,14 Bleomycin 11056-06-7 14 Methanol 67-56-1 7,10,12 Borates, anhydrous NA 12 Methazole 20354-26-1 6 Borax glass 1330-43-4 7 Methimazole 60-56-0 6,14 Boric acid 10043-35-3 7,10,12 Methiocarb 2032-65-7 7 Boron oxide 1303-86-2 7 Methomyl 16752-77-5 7 Boron trichloride 10294-34-5 7 Methotrexate 59-05-2 6,7,10,14 Bromacil 314-40-9 6,7 Methotrexate sodium 15475-56-6 6,14 Bromadiolone 28772-56-7 7 Methoxsalen 298-81-7 14 Bromides NA 14 (anticonvulsant/sedative) Bromine 7726-95-6 7 Methoxychlor 72-43-5 10 Bromocriptine 25614-03-3 14 Methoxyethoxy ethanol 111-77-3 7,10 1-Bromopropane 106-94-5 6,11,12 Methoxyethylmercuric acetate 151-38-2 7 2-Bromopropane 75-26-3 6,12 Methoxyflurane 76-38-0 10,12 Bromoxynil 1689-84-5 6 2-Methoxypropyl acetate 70657-70-4 10 Bromoxynil octanoate 1689-99-2 6 Methyl benzimidazole 1065-21-7 10 Brompheniramine 86-22-6 14 Methyl bromide 74-83-9 6 Bumetanide NA 14 Methyl chloride 74-87-3 6,10–12 Busulfan 55-98-1 6,7,14 Methylene blue 61-73-4 14 Butabarbital sodium 143-81-7 6 Methylene chloride 75-09-2 7,10 1,3-Butadiene 106-99-0 6,10,12,14 4,4-Methylenedianiline 101-77-9 7 Butanol 75-65-0 7,10 Methyl ethyl ketone 78-93-3 7,10 Butazone 50-33-9 14 Methyl ethyl ketone peroxide 1338-23-4 7

36 Journal of Chemical Health & Safety, January/February 2010 Table 1 (Continued ) Chemical name CAS #a Ref.b Chemical name CAS #a Ref.b Butiphos NA 14 N-Methyl formamide 123-39-7 10 2-Butoxyethyl acetate 112-07-2 12 Methylhydrazine 60-34-4 12 n-Butyl acetate 123-86-4 7 Methyl isobutyl ketone 108-10-2 10 n-Butyl glycidal ether 2426-08-6 11 Methyl isocyanate 624-83-9 7,10,12,14 Butylated urea formaldehyde NA 7 Methyl mercaptan 74-93-1 7 Butyl benzyl phthalate 85-68-7 6,7 Methyl mercuric dicyanamide 502-39-6 7 1,2-Butylene oxide 106-88-7 7 Methyl mercury 22967-92-6 6,10,14 n-Butyl mercaptan 109-79-5 12 Methyl methacrylate 80-62-6 7 Butyronitrile 10232-92-5 10 N-Methyl-3,4- 69610-10-2 14 methylenedioxyamphetamine Cacodylic acid 75-60-5 7,10 Methyl metiram 8064-35-5 10 Cadmium 7440-43-9 6,7,12,14 Methyl parathion 298-00-0 7 Cadmium acetate 543-90-8 7,12 N-Methylpyrrolidone 872-50-4 6,7,10,12 Cadmium acetate dihydrate 5743-04-4 7,12 a-Methyl styrene 98-83-9 7,11 Cadmium chloride 10108-64-2 10,12 Methyl tert-butyl ether 1634-04-4 12 Cadmium compounds NA 12 Methyltestosterone 58-18-4 6,14 Cadmium hydroxide 21041-95-2 7,12 Methyl thiocyanate 556-64-9 7 Cadmium stearate 2223-93-0 7,12 Methylthiouracil 56-04-2 14 Cadmium sulfate 10124-36-4 7,12 Metiram 9006-42-2 6 Cadmium sulfide 1306-23-6 7,12 Metolcarb 1121-49-5 7 Caffeine 58-08-2 7 Metronidazole 443-48-1 14 Calcitriol 32222-06-3 14 Mevinphos 7786-34-7 7 Calcium arsenate 10103-62-5 7 Mexacarbate 315-18-4 7 Calcium chromate 13765-19-0 12 Midazolam HCl 59467-96-8 6,14 Calcium cyanide 592-01-8 7 Mifepristone 84371-65-3 14 Calcium fluoride 7789-75-5 7 Minocycline 13614-98-7 6,14 Calcium hypochlorite 7778-54-3 7 Mintezol 148-79-8 10 Calcium permanganate 10118-76-0 12 Mirex 2385-85-5 10,14 Calcium sulfide 1344-81-6 7 Misoprostal 59122-46-2 6,14 Captan 133-06-2 10,12 Mitomycin C 50-07-7 7,14 Captopril 62571-86-2 14 Mitoxantrone 70476-82-3 6,14 Carbachol chloride 51-83-2 7 Molybdate lead chromate 12709-98-7 7 Carbamazepine 298-46-4 6,14 Molybdenum 7439-98-7 7,10 Carbamizole 22232-54-8 14 Monochlorodifluoromethane 75-45-6 7 Carbarson 121-95-5 14 Monocrotophos 6923-22-4 7 Carbaryl 63-25-2 7,10–12,14 Morpholine 24602-86-6 10 Carbendazim 37953-07-4 14 Muscovite mica NA 7 Carbofuran 1563-66-2 7,10 Mustard Gas 505-60-2 7,10 Carbon black 1333-86-4 7 Myclubutanil 88671-89-0 6 Carbon dioxide 124-38-9 7,10 Nabam 142-59-6 6 Carbon disulfide 75-15-0 6,7,10,12,14 Nafarelin acetate 86220-42-0 6,14 Carbon monoxide 630-08-0 6,7,10,12,14 Nandrolone 434-22-0 14 Carbon tetrachloride 56-23-5 7 Naphtha 64742-95-6 7,10 Carbonyl sulfide 463-58-1 7 Naphthalene 91-20-3 7 Carbophenothion 786-19-6 7 Natural gas NA 7 Carboplatin 41575-94-4 6,14 Neomycin sulfate 1405-10-3 6,14 Cartap 15263-52-2 10 Netilmicin 56391-57-2 6,14 Chenodiol 474-25-9 6,14 Nickel 7440-02-0 7,10,12,14 Chlorambucil 305-03-3 6,7,14 Nickel (II) chloride 7718-54-9 10 Chloramphenical 56-75-7 10,14 Nickel (II) sulfate 7768-81-4 7 Chlorcyclizine HCl 1620-21-9 6 Nickel carbonyl 13463-39-3 6,7,10,12 Chlordane 12789-03-6 7 Nickel compounds NA 10,12 Chlordiazepoxide 438-41-5 14 Nickel oxide 1313-99-1 7 Chlordiazepoxide 58-25-3 6,14 Nicotine 54-11-5 6,7,10,14 Chlorhydrin 96-24-2 10 Nicotine sulfate 65-30-5 7 Chlorine 7782-55-5 7 Nifedipine 21829-25-4 6

Journal of Chemical Health & Safety, January/February 2010 37 Table 1 (Continued ) Chemical name CAS #a Ref.b Chemical name CAS #a Ref.b Chlorine dioxide 10049-04-4 10 Nimodipine 66085-59-4 6 Chloroacetic acid 79-11-8 7 Nitrapyrin 1929-82-4 6 Chlorobenzene 108-90-7 10 Nitrates NA 12 Chlorodiphenyl (42% chlorine) 53469-21-9 12 Nitric acid 7697-37-2 7 Chlorodiphenyl (54% chlorine) 11097-69-1 10,12 Nitriles NA 12 1-(2-Chloroethyl)-3- 13909-09-6 6 Nitrites NA 12 methylcyclohexyl- 1-nitrosourea Chloroform 67-66-3 7,10,12 Nitrobenzene 98-95-3 7,12 5-Chloro-2-methyl-4- 26172-55-4 7 4-Nitrobiphenyl 92-93-3 7 isothiazolin-3-one HCl Chloromethyl mercury 115-09-3 10 Nitrofen 1836-75-5 10 Chloronaphthalene 25586-43-0 7 Nitrofurantoin and related 67-20-9 7,14 agents Chlorophacinone 3691-35-8 7 Nitrofurazone 59-87-0 10 b-Chloroprene 126-99-8 12 Nitrogen dioxide 10102-44-0 7,10 1-Chloro-2-propanol 127-00-4 12 Nitrogen mustard 51-75-2 6,12,14 2-Chloro-1-propanol 78-89-7 12 Nitrogen mustard HCl 55-86-7 6,14 2-Chloropropionic acid 598-78-9 11,12 Nitromethane 75-52-5 7 Chlorothiazide 58-94-6 14 1-Nitropropane 108-03-2 7 Chlorotrianisene 569-57-3 14 Nitrosomethylurea 684-93-5 10,14 Chlorpropamide 94-20-2 14 2-Nitrotoluene 88-72-2 10 Chlorpyrifos 2921-88-2 7 Nitrous oxide 10024-97-2 7,10–12 Chlorsulfuron 64902-72-3 6 Nonoxynol-9 26571-11-9 7 Chlortetracycline 57-62-5 14 Norethisterone acetate 51-98-9 6 Cholecalciferol 67-97-0 14 Norethisterone/ethinyl estradiol 68-22-4/ 6 57-63-6 Chromates NA 12 Norethisterone/mestranol 68-22-4/ 6 72-33-3 Chromic acid 7738-94-5 12 Norethynodrel 68-23-5 14 Chromium 7440-47-3 7,12 Norfloxacin 70458-96-7 14 Chromium compounds NA 12 Norgesrtel 6533-00-2 6 Chromium hexavalent salts NA 7 Norgesrtel/ethinyl estradiol 6533-00-2/ 14 57 63-6 Chromium trioxide 1333-82-0 7,12 Norgestimate/ethinyl estradiol 35189-28-7/ 14 57-63-6 Chromyl chloride 14977-61-8 12 Nortryptyline HCl 894-71-3 14 Cidofovir 113852-37-2 6,14 Octamethylpyrophosphoramide 152-16-9 7 Ciguatoxin NA 14 Octyl acetate 112-14-1 7 Cinoxacin 28657-80-9 14 n-Octyl bicycloheptene 113-48-4 7 dicarboximide Ciprofloxin 85721-33-1 14 Ofloxacin 82419-36-1 14 Cisplatin 15663-27-1 14 Omeprazole 73590-58-6 14 Cladribine 4291-63-8 6,14 Oryzalen 19044-88-3 14 Clarithomycin 81103-11-9 6 Ouabain 630-60-4 7 Clay NA 7 Oxadiazon 19666-30-9 6 Clobetasol propionate 25122-46-7 6 Oxalic acid 144-62-7 7 Clofibrate NA 14 Oxandrolone 53-39-4 14 Clomiphene 50-41-9 6,14 Oxazepam 604-75-1 6,14 Clomocycline 1181-54-0 14 p,p0-Oxybis(benzenesulfonyl 80-51-3 11 hydrazide) Clorazepate dipotassium 57109-90-7 6,14 Oxydemeton methyl 301-12-2 6,14 Coal tar NA 7,12 10,10-Oxidiphenoxarsine 58-36-6 7 Cobalt 7440-48-4 7 Oxygen 7782-44-7 7,10 Cobalt (II) chloride 7646-79-9 7 Oxymetholone 434-07-1 6,14 Cobalt (II) nitrate 10141-05-6 7 Oxytetracycline 79-57-2 6,14

38 Journal of Chemical Health & Safety, January/February 2010 Table 1 (Continued ) Chemical name CAS #a Ref.b Chemical name CAS #a Ref.b Cocaine 50-36-2 6,7,14 Oxytetracycline HCl 205-46-0 6,14 Codeine phosphate 52-28-8 6 Oxythioquinox 2439-01-2 6 Colchicine 64-86-8 6,7,14 Ozone 10028-15-6 7 Conjugated estrogens NA 6,14 Pacitaxel 33069-62-4 6,14 Copper 7440-50-8 7,14 Paramethadione 115-67-3 6,14 Copper (II) nitrate 10031-43-3 7 Paraquat 1910-42-5 7,12 Copper (II) oxide 1317-38-0 7 Paraquat methosulfate 2074-50-2 7 Copper (II) sulfate 7758-98-7 7 Parathion 56-38-2 7 Copper naphthenate 1338-02-9 7 Paris green 12002-03-8 7 Cortisone 53-06-5 14 PCB’s NA 7,10 Coumatetralyl 5836-29-3 7 Penicillamine 52-67-5 6,14 Creosote NA 7 Pentaborane 19624-22-7 7 Cresol 1319-77-3 7 Pentachlorophenol 87-86-5 7 Cresyl glycidyl ether 26447-14-3 7 Pentostatin 53910-25-1 6,14 Crude oil 8002-05-9 7 Perchloroethylene 127-18-4 7,10,12,14 Cumene hydroperoxide 80-15-9 7 Phenacemide 63-98-9 6,14 Cyanazine 21725-46-2 6 1,10-Phenanthroline 66-71-7 7 Cyanogen 460-19-5 7 Phencyclidine 60124-79-0 14 Cyanogen bromide 508-68-3 7 Phenindione 83-12-5 14 Cyanogen iodide 506-78-5 7 Phenobarbitol 57-33-0 6,7,14 Cycloate 1134-23-2 6 Phenol 108-95-2 7,10 Cyclohexamide 66-81-9 14 Phenprocoumon 435-97-2 6,14 Cyclohexanone 108-94-1 7,10 Phenyl arsine oxide 637-03-6 12 Cyclohexylamine 108-91-8 10 Phenyl glycidyl ether 122-60-1 11 Cyclophosphamide 50-18-1 6,10 Phenyl ether 101-84-8 7 Cyclosporin 79217-60-0 14 Phenyl mercuric acetate 62-84-4 10,12 Cyhexatin 13121-70-5 6 2-Phenylphenol 90-43-7 7 Cyproterone 427-51-0 14 Phenylphosphine 638-21-1 10–12 Cytarabine 147-94-4 6,14 Phenytoin 57-41-0 6,14 2,4-D 94-75-7 7,10–12,14 Phenytoin sodium salt 630-93-3 7,14 Dacarbazine 4342-03-4 6 Phorate 298-02-2 7 Danazol 17230-88-5 6,14 Phosmet 732-11-6 10 Daunorubicin 20830-81-3 14 Phosphamidon 13171-21-6 7 Daunorubicin HCl 23541-50-6 6,14 Phosphate rock NA 7 2,4-D butyl ester 94-80-4 10 Phthalate esters NA 12 2,4-D butyric acid 94-82-6 6 Pimozide 2062-78-4 6 2,4-DDD 53-19-0 10 Piperidine 110-89-4 7 2,4-D diethanolamine salt 2008-39-1 7 Piperonyl butoxide 51-03-6 7,10 Decanol 112-30-1 7 Pipobroman 54-91-1 6,14 Demeclocycline HCl 64-73-3 6,14 Plicamycin 18378-89-7 6,14 2,4-Diaminotoluene 95-80-7 10 Polybrominated biphenyl 67774-32-7 6,10,12 Diazepam 439-14-5 6,14 Polychlorinated biphenyl 1336-36-3 6,10,14 Diazinon 333-41-5 7 Polycyclic aromatic NA 12 hydrocarbons Diazoxide 364-98-7 6,14 Polydimethylsiloxane 63148-62-9 7 Dibenzofuran 57117-31-4 10 Polyethylene glycol 25322-68-3 7 Diborane 19287-45-7 7 Polymerized linseed oil 67746-08-1 7 1,2-Dibromo-3-chloropropane 96-12-8 10,12,14 Polymethylmethacrylate 9011-14-7 7 Di-n-butyl phthalate 84-74-2 6,10–12 Polyvinyl acetate 9003-20-7 7 Dichlofop 51338-27-3 6 Potassium arsenite 10124-50-2 7 Dichloroacetic acid 79-43-6 12 Potassium chromate 7789-00-6 7 1,3-Dichlorobenzene 541-73-1 7 Potassium cyanide 151-50-8 7 1,4-Dichlorobenzene 106-46-7 10 Potassium dichromate 7778-50-9 7,12 1,1-Dichloroethane 75-34-3 7 Potassium 128-03-0 6 dimethyldithiocarbamate 1,1-Dichloro-1-fluoroethane 1717-00-6 7 Potassium fluoride 7789-23-3 7

Journal of Chemical Health & Safety, January/February 2010 39 Table 1 (Continued ) Chemical name CAS #a Ref.b Chemical name CAS #a Ref.b Dichlorophene 97-23-4 6 Potassium iodide 7681-11-0 10,14 Dichloro-s-triazinetrione 2782-57-2 7 Potassium permanganate 7722-64-7 7,12 Dichlorphenamide 120-97-8 6 Potassium silver cyanide 506-61-6 7 Dichlorvos 62-73-7 7,10 Potassium thiocyanate 333-20-0 7 Dicumerol 66-76-2 6,10,14 Povidone/iodine 25655-41-8 14 Dicycolamine 67-92-5 14 Pravastatin sodium 81131-70-6 6,14 o,p-DDT 789-02-6 6,10,14 Prednisolone sodium 125-02-0 6 phosphate p,p-DDT 50-29-3 6,7,10,14 Primidone 125-33-7 14 Dieldrin 60-57-1 7,10 Procarbazine 671-16-9 14 Dienestrol 84-17-3 14 Procarbazine HCl 366-70-1 6,14 Diethylamine 109-89-7 7 Promecarb 2631-37-0 7 Diethylcarbamazine citrate 1642-54-2 7 Prometon 1610-18-0 7 Diethylene glycol 111-46-6 7,10 n-Propanol 71-23-8 7 Diethylene glycol 111-96-6 12 Propargite 2312-35-8 6 dimethyl ether Diethylene glycol 112-34-5 12 Propionic acid 120-36-5 10 monobutyl ether Diethylene glycol 111-90-0 12 Propoxur 114-26-1 7,10 monoethyl ether Diethylene glycol 112-59-4 12 Propylene dichloride 78-87-5 12 monohexyl ether Diethylene glycol 104-68-7 12 Propylene glycol 57-55-6 7 monophenyl ether Di(2-ethylhexyl) phthalate 117-81-7 14 Propylene glycol methyl 108-65-6 7 ethyl ether acetate Diethylnitrosamine 55-18-5 10 Propylene glycol 1569-02-4 7 monoethyl ether Diethyl phthalate 84-66-2 12 Propylene glycol 107-98-2 12 monomethyl ether Diethylstilbestrol 56-53-1 6,7,10,14 Propylene oxide 75-56-9 7 N,N-Diethyl-m-toluamide 134-62-3 7 Propylthiouracil 51-52-5 6,7,14 Diflunisal 22494-42-4 6,14 Purimethamine 58-14-0 6 Difolatan 2425-06-1 10 PVC resin NA 7 Digitoxin 71-63-6 7 Pyrethrins NA 7 Diglycidyl ether 2238-07-5 7,10–12 Pyridine 110-86-1 7 Digoxin 20830-75-5 7 Pyrimethamine 58-14-0 14 Di-n-hexyl phthalate 84-75-3 6 Quazepam 36735-22-5 6,14 Dihydroergotamine mesylate 6190-39-2 6,14 Quinapril 85441-61-8 14 Dihydrorotenone 6659-45-6 7 Quinine 130-95-0 14 Diisodecyl phthalate 68515-49-1 6 Quizalofop-ethyl 76578-14-8 6 2973-10-6 2,4-D isooctyl ester 25168-26-7 10 Ramipril 87333-19-5 14 Diisopropyl fluorophosphate 55-91-4 7 Resmethrin 10453-86-8 6 Diltiazem 33286-22-5 6 Resorcinol methyl ether 150-19-6 10 Dimethoate 60-51-5 7,10 Retinol 68-26-8 14 N,N-Dimethylacetamide 127-19-5 10–12 Retinol esters NA 14 Dimethylaminopropionitrile 1738-25-6 14 Ribavirin 36791-04-5 6 N,N-Dimethylaniline 121-69-7 7 Rifampin 13292-46-1 6 Dimethylbenzanthracene 57-97-6 10 Ronnel 299-84-3 10 Dimethylformamide 68-12-2 7,10 Rotenone 83-79-4 7 1,1-Dimethylhydrazine 57-14-7 12 Secobarbital 309-43-3 6 Dimethylnitrosamine 62-75-9 10 Selenium 7782-49-2 7,12 Dimethylphthalate 131-11-3 7,12 Selenium compounds NA 12 Dimethyl-2-thiourea 534-13-4 10 Selenium oxychloride 7791-23-3 7 1,3-Dimethylurea 96-31-1 10 Sermorelin acetate 86168-78-7 6

40 Journal of Chemical Health & Safety, January/February 2010 Table 1 (Continued ) Chemical name CAS #a Ref.b Chemical name CAS #a Ref.b 1,3-Dinitrobenzene 99-65-0 6 Silica, crystalline 14808-60-7 7 1,4-Dinitrobenzene 100-25-4 6 Simazine 122-34-0 7 4,6-Dinitro-o-cresol and salts NA 7 Simvastin 79902-63-9 14 Dinitrotoluene 25321-14-6 10–12 Sodium arsenate 10048-95-0 7,10 2,4-Dinitrotoluene 121-14-2 6,7,14 Sodium arsenite 7784-46-5 7,10 2,6-Dinitrotoluene 606-20-2 6,14 Sodium azide 26628-22-8 7,12 Dinocap 39300-45-3 6,10,12,14 Sodium cacodylate 124-65-2 7 Dinoseb 88-85-7 6,7,10,14 Sodium carbonate 497-19-8 7 Dinoterb 1420-07-1 7 Sodium chloride 7647-14-5 7 Dioctyl phthalate 117-81-7 6,7,10,12 Sodium chlorite 7758-19-2 10 Dioxane 123-91-1 7 Sodium chromate 7775-11-3 7 Dioxins NA 7 Sodium cyanide 143-33-9 7 1,3-Dioxolane 646-06-0 12 Sodium dichromate 7789-12-0 7 Diphacinone 82-66-6 7 Sodium 128-04-1 6 dimethyldithiocarbamate Diphenhydramine 58-73-1 14 Sodium 68081-81-2 7 dodecyl benzenesulfonate N,N-Diphenyl-p- 74-31-7 10 Sodium fluoride 7681-49-4 10 phenylenediamine Dipropylene glycol 34590-94-8 12 Sodium fluoroacetate 62-74-8 6,7 methyl ether Diquat dibromide 85-00-7 7 Sodium hydroxide 1310-73-2 7 Disodium 138-93-2 6,14 Sodium iodide 7681-82-5 7,10,14 cyanodithioimidocarbonate Disodium octaborate 12008-41-2 7 Sodium metavanadate 13718-26-8 7 tetrahydrate Disulfiram 97-77-8 10,14 Sodium nitrite 7632-00-0 7,10 Diuron 330-54-1 7 Sodium pentachlorophenate 131-52-2 7 Dodecylbenzenesulfonic acid 27176-87-0 7 Sodium selenate 13410-01-0 7,10 1 DowSeparan AP30 NA 7 Sodium selenite 10102-18-8 10 synthetic polymer Doxorubicin HCl 23214-92-8 6,14 Sodium silicate 6834-92-0 7 Doxycycline 564-25-0 6,14 Sodium silicofluoride 16893-85-9 7 Doxycycline calcium 94088-85-4 6 Sodium sulfate 7757-82-6 7 Doxycycline hyclate 24390-14-5 6 Sodium sulfite 7757-83-7 7 Doxycycline monohydrate 17086-28-1 6 Sodium tellurite 10102-20-2 7 2,4-D PGBE 1320-18-9 7 Soya lecithin 8002-43-5 7 Enalapril 75847-73-3 14 Stanozolol 10418-03-8 14 Endosulfan 115-29-7 7 Stoddard solvent 8052-41-3 7 Endrin 72-20-8 6,7,10 Streptomycin 57-92-1 14 Enflurane 13838-16-9 10,12 Streptomycin sulfate 3810-74-0 6,14 Epichlorohydrin 106-89-8 6,10–12,14 Streptozocin 18883-66-4 6,14 Epoxy resin NA 7 Strontium chromate 7789-06-2 12 Epoxyethylbenzene 96-09-3 10 Strontium nitrate 10042-76-9 7 Ergocalciferol 50-14-6 10 Styrene 100-42-5 7,10 Ergotamine 113-15-5 14 Sulfonamides NA 14 Ergotamine tartrate 379-79-3 6,7 Sulfur 7704-34-9 7 Estazolam 29975-16-4 14 Sulfur dioxide 7446-09-5 7,10 Estradiol 50-82-2 14 Sulfuric acid 7664-93-9 7 Estropipate 7280-37-7 6,14 Sulindac 38194-50-2 6,14 2-Ethoxyethoxy ethanol 111-90-5 7 2,4,5-T 93-76-5 10,12 2-Ethoxyethyl acetate 111-15-9 10–12 Talc 14807-96-6 7 Ethanol 64-17-5 7,10,12,14 Tamoxifen citrate 54965-24-1 6,14 Ethanolamine 141-43-5 7 2,4,5-T butyl ester 93-79-8 10 Ethinyl estradiol 57-63-6 14 Tellurium and compounds NA 7,12 Ethionamide 536-33-4 6 Temazepam 846-50-4 6,14

Journal of Chemical Health & Safety, January/February 2010 41 Table 1 (Continued ) Chemical name CAS #a Ref.b Chemical name CAS #a Ref.b Ethisterone 434-03-7 14 Teniposide 29767-20-2 6,14 Ethyl acetate 141-78-6 7 Terbacil 5902-51-2 6 Ethyl acrylate 140-88-5 7 Terbufos 13071-79-9 7 Ethyl biscoumacetate 548-00-5 14 tert-Amyl methyl ether 994-05-8 10,12 Ethylbenzene 100-41-4 7 tert-Butyl chromate 1189-85-1 12 Ethyl tert-butyl ether 637-92-3 11,12 Tertraglyme 143-24-8 10 Ethyl chloride 75-00-3 7 Testosterone 58-22-0 14 Ethyl dipropylthiocarbamate 759-94-3 6 Testosterone cypionate 58-20-8 6 Ethylene dibromide 106-93-4 6,7,10,12,14 Testosterone enanthate 315-37-7 6,14 Ethylene dichloride 107-06-2 7 2,3,7,8-Tetrachlorobenzo- 1746-01-6 6,10,14 p-dioxin Ethyl ether 60-29-7 7 Tetrachloroethylene 127-18-4 12 Ethylene fluorohydrin 371-62-0 7 Tetracycline 60-54-8 6,14 Ethylene glycol 107-21-1 7,10 Tetracycline HCl 116-14-3 6 Ethylene glycol butyl ether 111-76-2 7,10,12 Tetraethyl lead 78-00-2 7,10 Ethylene glycol diethyl ether 629-14-1 10 Tetrahydrofuran 109-99-9 7,10 Ethylene glycol dimethyl ether 110-71-4 10 Tetramethyl lead 75-74-1 7 Ethylene glycol ethyl ether 110-80-5 6,7,10–12,14 Tetranitromethane 509-14-8 7 Ethylene glycol methyl ether 109-86-4 6,7,10–12,14 Tetrasodium pyrophosphate 7722-88-5 7 Ethylene glycol monoethyl 111-15-9 6,7,10–12 Thalidomide 50-35-1 6,7,14 ether acetate Ethylene glycol monomethyl 2807-30-9 10 Thiadiazole 26907-37-9 10 ether acetate Ethylene glycol 110-49-6 6,7,10–12,14 Thioguanine 154-42-7 6,14 monopropyl ether Ethyl methane sulfonate 62-50-0 10 Thiophanate methyl 23564-05-8 6 Ethylene oxide 75-21-8 6,7,10,12,14 Thiotepa 52-24-4 14 Ethyl thiocyanate 542-90-5 7 Thiourea 62-56-6 10 Ethylene thiourea 96-45-7 6,10,12,14 Thiram 137-26-8 10 Ethylenediamine 107-15-3 7 Tin 7440-31-5 7 Ethyleneimine 151-56-4 7 Titanium 7440-32-6 7 2-Ethyl-1-hexanol 104-76-7 10 Tobramycin 32986-56-4 14 2-Ethylhexanoic acid 149-57-5 11,12 Tobramycin sulfate 49842-07-1 6,14 Ethylnitrosourea 759-73-9 14 Toluene 108-83-3 6,7,10–12,14 Ethynodiol acetate 297-76-7 14 Toluene 2,4-diamine 95-80-7 14 Etodolac 41340-25-4 6,14 Toluene diisocyanate 26471-62-5 7 Etoposide 33419-42-0 6,14 2-Toluenesulfonic acid 88-19-7 10 Etretinate 54350-48-0 6,14 Toxaphene 8001-35-2 7,10 Famciclovir 104227-87-4 14 trans-Retinoic acid 302-79-4 6,14 Fenamiphos 22224-92-6 7 Triadimefon 43121-43-3 6 Fenitrothion 122-14-5 7 Triamiphos 1031-47-6 7 Fenoxaprop 66441-23-4 6 Triazofos 24017-47-8 7 Ferbam 14484-64-1 10,12 Triazolam 28911-01-5 6,14 Ferric nitrate 7782-61-8 7 Tributyltin methacrylate 2155-70-6 6 Filgrastim 121181-53-1 6 Tributyltin oxide 56-35-9 7,10 Finasteride 98319-26-7 14 Trichlorfon 52-68-6 7,10,14 Firemaster BP-6 58536-65-1 10 Trichloroacetic acid 76-03-9 7 Fluazifop butyl 69806-50-4 6 Trichloroethane NA 7 Fludarabine 21679-14-1 14 Trichloroethylene 79-01-6 7,10,14 Flunisolide 3385-03-3 6 Tridiphane 58138-08-2 10 Flunitrazapam 1622-62-4 14 Trientine HCl 38260-01-4 6 Fluoride NA 7 Triethanolamine 102-71-6 7 Fluoroacetic acid 144-49-0 7 Triethylene glycol 112-27-6 10 Fluoroacetyl chloride 359-06-8 7 Triethylene glycol dimethyl 112-49-2 10 ether Fluorosilicate ion NA 7 Triethylenemelamine 51-18-3 10

42 Journal of Chemical Health & Safety, January/February 2010 Table 1 (Continued ) Chemical name CAS #a Ref.b Chemical name CAS #a Ref.b Fluorouracil 51-21-8 6,7,14 Triethylenetetramine 112-24-3 10 Fluoxetine 54910-89-3 7 Trifluralin 1582-09-8 10 Fluoxymesterone 76-43-7 6,14 Triforine 26644-46-2 6 Flurazepam HCl 1172-18-5 6,14 Triglycidal isocyanurate 2451-62-9 12 Flurbiprofen 5104-49-4 6 Trilostan 13647-35-3 6,14 Fluroxene 406-90-6 12 Trimethadione 127-48-0 6,14 Flutamide 13311-84-7 6,14 Trimethylphosphate 512-56-1 10 Fluticasone propionate 80474-14-2 6 Trimethyltin chloride 1066-45-1 7 Fluvalinate 69409-94-5 6 Trimetrexate glucuronate 82952-64-5 6,14 Fluvastatin 93957-54-1 14 Tripelennamine 91-81-6 14 Folpet 133-07-3 10 Triphenyltin chloride 639-58-7 7 Formaldehyde 50-00-0 7 Triphenyltin hydroxide 76-87-9 6 Formaldehyde cyanohydrin 107-16-4 7 Tris(2-chloroethyl)amine 555-77-1 12 Formamide 75-12-7 10 Tungsten 7440-33-7 7 Formetanate HCl 23422-53-9 7 Turpentine oil 8006-64-2 7 Formparanate 17702-57-7 7 Uracil mustard 66-75-1 6,14 Fosinopril 98048-97-6 14 Urea 57-13-6 7 Fuel oil #2 68476-30-2 7 Urethane 51-79-6 6,10,14 Fungaflor 35554-44-0 10 Urofollitropin 97048-13-0 6,14 Furlfuramide 3688-53-7 10 Valproate sodium 1069-66-5 14 Gallium-arsenide 1303-00-0 10 Valproic acid 99-66-1 6,7,14 Ganciclovir sodium 82410-32-0 6,14 Vanadium pentoxide 1314-62-1 7 Gasoline 8006-61-9 7,14 Vinblastine 865-21-4 14 Gatifloxacin 112811-59-3 14 Vinblastine sulfate 143-67-9 6,14 Gemfibrozil 25812-30-0 6,14 Vinclozolin 50471-44-8 6 Gentamycin 1403-66-3 14 Vincristine sulfate 2068-78-2 6,14 Glycidol 556-52-5 10 Vinyl acetate 108-05-4 7 Glycol ethers NA 10,12 Vinyl chloride 75-01-4 7,10,12,14 Goserelin 65807-02-5 6,14 4-Vinyl cyclohexene 100-40-3 11,12 Gossypol 303-45-7 10 Vinyl cyclohexene dioxide 106-87-6 11,12 Granular triple superphosphate 10031-30-8 7 Vinylidene chloride 75-35-4 7,10 Halazepam 23092-17-3 6,14 Vitamin D NA 7 Halobetasol propionate 66852-54-8 6 VX 50782-69-9 7 Haloperidol 52-86-8 6 Warfarin 81-81-2 6,7,10,14 Halothane 151-67-7 6,10,12 Warfarin sodium 129-06-6 7 Heat NA 7 Xylenes 1330-20-7 7,10,12,14 Helium 7440-59-7 7 Zileuton 111406-87-2 6 Hepachlor 76-44-8 6,7 Zinc chromate 13530-65-9 7,12 Heroin 561-27-3 7,14 Zinc dithiophosphate 19210-06-1 7 Hexachlorobenzene 118-74-1 6,10,14 Zinc nitrate 7779-88-6 7 Hexachlorophene 70-30-4 10,12 Zinc oxide 1314-13-2 7 Hexafluoroacetone 684-16-2 11,12 Zinc salts of NA 7 dialkylphosophorodithiotic acid Hexamethylene diisocyanate 822-06-0 7 Zinc sulfate 7733-02-0 10 2,5-Hexanedione 110-13-4 10 a Chemical Abstracts Services Registry Number.b References taken from text. References are: 6 = California Proposition 65; 7 = Reprotext; 10 = Jankovic and Drake; 11 = ACGIH; 12 = NIH (Haz-Map); 14 = US Navy/USMC.

Journal of Chemical Health & Safety, January/February 2010 43 Table 2. Combined Listing of Reproductive Toxicants Sorted by CAS Number. This is a listing of chemical reproductive toxicants taken from California Proposition 65,6 Reprotext1 (using chemicals rated ‘‘A’’, known and unconfirmed human reproductive toxicants, and ‘‘B’’, known animal reproductive toxicants),7 Jankovic and Drake,10 ACGIH,11 Haz-Map,12 and the Navy and Marine Corps Public Health Center Technical Manual.14 NA indicates that the product listed is either a mixture, chemical class or that there was not enough information present to assign a CASRN. CAS #a Chemical name Ref.b CAS #a Chemical name Ref.b 50-00-0 Formaldehyde 7 822-06-0 Hexamethylene diisocyanate 7 50-07-7 Mitomycin C 7,14 846-49-1 Lorazepam 6,14 50-14-6 Ergocalciferol 10 846-50-4 Temazepam 6,14 50-18-1 Cyclophosphamide 6,10 865-21-4 Vinblastine 14 50-29-3 p,p-DDT 6,7,10,14 872-50-4 N-Methylpyrrolidone 6,7,10,12 50-32-8 Benzo(a)pyrene 7,10 894-71-3 Nortryptyline HCl 14 50-33-9 Butazone 14 900-95-9 Acetoxytriphenylstannane 7 50-35-1 Thalidomide 6,7,14 919-16-4 Lithium citrate 6,14 50-36-2 Cocaine 6,7,14 994-05-8 tert-Amyl methyl ether 10,12 50-41-9 Clomiphene 6,14 1031-47-6 Triamiphos 7 50-76-0 Actinomycin D 6,7,14 1065-21-7 Methyl benzimidazole 10 50-82-2 Estradiol 14 1066-45-1 Trimethyltin chloride 7 51-03-6 Piperonyl butoxide 7,10 1069-66-5 Valproate sodium 14 51-18-3 Triethylenemelamine 10 1121-49-5 Metolcarb 7 51-21-8 Fluorouracil 6,7,14 1134-23-2 Cycloate 6 51-52-5 Propylthiouracil 6,7,14 1162-65-8 Aflatoxin-B 10 51-75-2 Nitrogen mustard 6,12,14 1172-18-5 Flurazepam HCl 6,14 51-79-6 Urethane 6,10,14 1181-54-0 Clomocycline 14 51-83-2 Carbachol chloride 7 1184-57-2 Hydroxymethyl mercury 10 51-98-9 Norethisterone acetate 6 1189-85-1 tert-Butyl chromate 12 52-24-4 Thiotepa 14 1303-00-0 Gallium-arsenide 10 52-28-8 Codeine phosphate 6 1303-28-2 Arsenic pentoxide 6,7,12 52-67-5 Penicillamine 6,14 1303-86-2 Boron oxide 7 52-68-6 Trichlorfon 7,10,14 1306-23-6 Cadmium sulfide 7,12 52-86-8 Haloperidol 6 1309-60-0 Lead oxide 7 53-06-5 Cortisone 14 1310-66-3 Lithium hydroxide 7 53-19-0 2,4-DDD 10 1310-73-2 Sodium hydroxide 7 53-39-4 Oxandrolone 14 1313-13-9 Manganese dioxide 7 53-86-1 Indomethacin 14 1313-99-1 Nickel oxide 7 54-11-5 Nicotine 6,7,10,14 1314-13-2 Zinc oxide 7 54-62-6 Aminopterin 6,7,10,14 1314-41-6 Lead oxide 7 54-91-1 Pipobroman 6,14 1314-62-1 Vanadium pentoxide 7 55-18-5 Diethylnitrosamine 10 1317-35-7 Manganese tetroxide 12 55-86-7 Nitrogen mustard HCl 6,14 1317-36-8 Lead oxide 7 55-91-4 Diisopropyl fluorophosphate 7 1317-38-0 Copper (II) oxide 7 55-98-1 Busulfan 6,7,14 1319-77-3 Cresol 7 56-04-2 Methylthiouracil 14 1320-18-9 2,4-D PGBE 7 56-23-5 Carbon tetrachloride 7 1327-53-3 Arsenic trioxide 6,7,12 56-35-9 Tributyltin oxide 10 1330-20-7 Xylenes 7,10,12,14 56-38-2 Parathion 7 1330-43-4 Borax glass 7 56-53-1 Diethylstilbestrol 6,7,10,14 1332-21-4 Asbestos 7 56-75-7 Chloramphenical 10,14 1332-58-7 Kaolin 7 57-13-6 Urea 7 1333-82-0 Chromium trioxide 7,12 57-14-7 1,1-Dimethylhydrazine 12 1333-86-4 Carbon black 7 57-33-0 Phenobarbitol 6,7,14 1336-21-6 Ammonium hydroxide 7 57-41-0 Phenytoin 6,14 1336-36-3 Polychlorinated biphenyl 6,10,14 57-53-4 Meprobamate 6,14 1338-02-9 Copper naphthenate 7 57-55-6 Propylene glycol 7 1338-23-4 Methyl ethyl ketone peroxide 7 57-62-5 Chlortetracycline 14 1344-28-1 Aluminum oxide 7 57-63-6 Ethinyl estradiol 14 1344-81-6 Calcium sulfide 7 57-92-1 Streptomycin 14 1403-66-3 Gentamycin 14 57-97-6 Dimethylbenzanthracene 10 1405-10-3 Neomycin sulfate 6,14

44 Journal of Chemical Health & Safety, January/February 2010 Table 2 (Continued ) CAS #a Chemical name Ref.b CAS #a Chemical name Ref.b 58-08-2 Caffeine 7 1420-07-1 Dinoterb 7 58-14-0 Purimethamine 6 1563-66-2 Carbofuran 7,10 58-14-0 Pyrimethamine 14 1569-02-4 Propylene glycol monoethyl ether 7 58-18-4 Methyltestosterone 6,14 1582-09-8 Trifluralin 10 58-20-8 Testosterone cypionate 6 1600-27-7 Mercuric acetate 6,7,14 58-22-0 Testosterone 14 1610-18-0 Prometon 7 58-25-3 Chlordiazepoxide 6,14 1620-21-9 Chlorcyclizine HCl 6 58-27-5 Menadione 14 1622-62-4 Flunitrazapam 14 58-36-6 10,10-Oxidiphenoxarsine 7 1634-04-4 Methyl tert-butyl ether 12 58-73-1 Diphenhydramine 14 1642-54-2 Diethylcarbamazine citrate 7 58-89-9 Lindane 7,10 1689-84-5 Bromoxynil 6 58-94-6 Chlorothiazide 14 1689-99-2 Bromoxynil octanoate 6 59-05-2 Methotrexate 6,7,10,14 1709-70-2 Antioxidant 330 7 59-66-5 Acetazolamide 6 1717-00-6 1,1-Dichloro-1-fluoroethane 7 59-87-0 Nitrofurazone 10 1738-25-6 Dimethylaminopropionitrile 14 59-92-7 Levodopa 6 1746-01-6 2,3,7,8-Tetrachlorobenzo- 6,10,14 p-dioxin 60-29-7 Ethyl ether 7 1752-30-3 Acetone thiosemicarbazide 7 60-34-4 Methylhydrazine 12 1836-75-5 Nitrofen 10 60-51-5 Dimethoate 7,10 1910-42-5 Paraquat 7,12 60-54-8 Tetracycline 6,14 1912-24-9 Atrazine 10 60-56-0 Methimazole 6,14 1929-82-4 Nitrapyrin 6 60-57-1 Dieldrin 7,10 2008-39-1 2,4-D diethanolamine salt 7 61-73-4 Methylene blue 14 2032-65-7 Methiocarb 7 61-82-5 Amitrol 10,12 2062-78-4 Pimozide 6 62-50-0 Ethyl methane sulfonate 10 2068-78-2 Vincristine sulfate 6,14 62-53-3 Aniline 7 2074-50-2 Paraquat methosulfate 7 62-56-6 Thiourea 10 2079-89-2 3-Aminopropionitrile fumarate 10 62-73-7 Dichlorvos 7,10 2155-70-6 Tributyltin methacrylate 6 62-74-8 Sodium fluoroacetate 6,7 2223-93-0 Cadmium stearate 7,12 62-75-9 Dimethylnitrosamine 10 2238-07-5 Diglycidyl ether 7,10–12 62-84-4 Phenyl mercuric acetate 10,12 2312-35-8 Propargite 6 63-25-2 Carbaryl 7,10–12,14 2385-85-5 Mi rex 10,14 63-98-9 Phenacemide 6,14 2425-06-1 Difolatan 10 64-17-5 Ethanol 7,10,12,14 2439-01-2 Oxythioquinox 6 64-19-7 Acetic acid 7 2451-62-9 Triglycidal isocyanurate 11,12 64-73-3 Demeclocycline HCl 6,14 2631-37-0 Promecarb 7 64-86-8 Colchicine 6,7,14 2782-57-2 Dichloro-s-triazinetrione 7 65-30-5 Nicotine sulfate 7 2807-30-9 Ethylene glycol 10 monomethyl ether acetate 66-27-3 Methanesulfonic acid 10,14 2921-88-2 Chlorpyrifos 7 66-71-7 1,10-Phenanthroline 7 2973-10-6 Diisodecylphthalate 6 66-75-1 Uracil mustard 6,14 3385-03-3 Flunisolide 6 66-76-2 Dicumerol 6,10,14 3687-31-8 Lead arsenate 12 66-81-9 Cyclohexamide 14 3688-53-7 Furlfuramide 10 67-20-9 Nitrofurantoin and related agents 7,14 3691-35-8 Chlorophacinone 7 67-56-1 Methanol 7,10,12 3778-73-2 Ifsoamide 6,14 67-63-0 Isopropyl alcohol 7 3810-74-0 Streptomycin sulfate 6,14 67-64-1 Acetone 7 3963-95-9 Methacycline 6,14 67-66-3 Chloroform 7,10–12 4044-65-9 Bitoscanate 7 67-92-5 Dicycolamine 14 4291-63-8 Cladribine 6,14 67-97-0 Cholecalciferol 14 4342-03-4 Dacarbazine 6 68-12-2 Dimethylformamide 7,10 4759-48-2 Isotretinoin 6,14 68-23-5 Norethynodrel 14 5104-49-4 Flurbiprofen 6 68-26-8 Retinol 14 5411-22-3 Benzphetamine HCl 6,14 68-96-2 Hydroxyprogesterone 14 5534-09-8 Beclomethasone dipropionate 6

Journal of Chemical Health & Safety, January/February 2010 45 Table 2 (Continued ) CAS #a Chemical name Ref.b CAS #a Chemical name Ref.b 70-30-4 Hexachlorophene 10,12 5634-39-9 Iodinated glycerol 14 (antitussive/expectorant) 70-69-9 p-Aminopropiophenone 7 5743-04-4 Cadmium acetate dihydrate 7,12 71-23-8 n-Propanol 7 5836-29-3 Coumatetralyl 7 71-43-2 Benzene 6,7,10,12,14 5902-51-2 Terbacil 6 71-58-9 Medroprogesterone acetate 6,14 5989-27-5 Limonene 7 71-63-6 Digitoxin 7 6112-76-1 Mercaptopurine 6,14 72-20-8 Endrin 6,7,10 6190-39-2 Dihydroergotamine mesylate 6,14 72-33-3 Mestranol 14 6484-52-2 Ammonium nitrate 7 72-43-5 Methoxychlor 10 6533-00-2 Norgesrtel 6 74-31-7 N,N-Diphenyl-p-phenylenediamine 10 6659-45-6 Dihydrorotenone 7 74-82-8 Methane 7 6834-92-0 Sodium silicate 7 74-83-9 Methyl bromide 6 6923-22-4 Monocrotophos 7 74-86-2 Acetylene 7 7280-37-7 Estropipate 6,14 74-87-3 Methyl chloride 6,10–12 7429-90-5 Aluminum 7 74-90-8 Hydrogen cyanide 7 7439-92-1 Lead 6,7,10,12,14 74-93-1 Methyl mercaptan 7 7439-93-2 Lithium 7,14 75-00-3 Ethyl chloride 7 7439-96-5 Manganese 7,12 75-01-4 Vinyl chloride 7,10,12,14 7439-97-6 Mercury 6,7,10,12,14 75-05-8 Acetonitrile 7,10,12 7439-98-7 Molybdenum 7,10 75-07-0 Acetaldehyde 7,10,14 7440-02-0 Nickel 7,10,12,14 75-09-2 Methylene chloride 7,10 7440-31-5 Tin 7 75-12-7 Formamide 10 7440-32-6 Titanium 7 75-15-0 Carbon disulfide 6,7,10,12,14 7440-33-7 Tungsten 7 75-21-8 Ethylene oxide 6,7,10,12,14 7440-36-0 Antimony 7 75-26-3 2-Bromopropane 6,12 7440-38-2 Arsenic 7,10,12,14 75-34-3 1,1-Dichloroethane 7 7440-41-7 Beryllium 7 75-35-4 Vinylidene chloride 7,10 7440-43-9 Cadmium 6,7,12,14 75-45-6 Monochlorodifluoromethane 7 7440-44-0 Activated carbon 7 75-52-5 Nitromethane 7 7440-47-3 Chromium 7,12 75-56-9 Propylene oxide 7 7440-48-4 Cobalt 7 75-60-5 Cacodylic acid 7,10 7440-50-8 Copper 7,14 75-74-1 Tetramethyl lead 7 7440-59-7 Helium 7 75-86-5 Acetone cyanohydrin 7 7440-67-7 Zirconium 7 76-03-9 Trichloroacetic acid 7 7440-69-9 Bismuth 7 76-38-0 Methoxyflurane 10,12 7446-09-5 Sulfur dioxide 7,10 76-43-7 Fluoxymesterone 6,14 7446-70-0 Aluminum chloride 10 76-44-8 Hepachlor 6,7 7487-94-2 Mercuric chloride 6,7,10,12,14 76-87-9 Triphenyltin hydroxide 6 7553-56-2 Iodine 7,10,14 78-00-2 Tetraethyl lead 7,10 7632-00-0 Sodium nitrite 7,10 78-83-1 Isobutyl alcohol 7 7646-79-9 Cobalt (II) chloride 7 78-87-5 Propylene dichloride 12 7647-01-0 Hydrogen chloride 7 78-89-7 2-Chloro-1-propanol 12 7647-14-5 Sodium chloride 7 78-93-3 Methyl ethyl ketone 7,10 7664-39-3 Hydrofluoric acid 7 78-97-7 Lactonitrile 7 7664-41-7 Ammonia 7 79-01-6 Trichloroethylene 7,10,14 7664-93-9 Sulfuric acid 7 79-06-1 Acrylamide 7,10,12 7681-11-0 Potassium iodide 10,14 79-10-7 Acrylic acid 7,12 7681-49-4 Sodium fluoride 10 79-11-8 Chloroacetic acid 7 7681-82-5 Sodium iodide 7,10,14 79-43-6 Dichloroacetic acid 11,12 7697-37-2 Nitric acid 7 79-57-2 Oxytetracycline 6,14 7704-34-9 Sulfur 7 80-05-7 Bisphenol A 10 7718-54-9 Nickel (II) chloride 10 80-15-9 Cumene hydroperoxide 7 7722-64-7 Potassium permanganate 7,12 80-62-6 Methyl methacrylate 7 7722-84-1 Hydrogen peroxide 7 81-81-2 Warfarin 6,7,10,14 7722-88-5 Tetrasodium pyrophosphate 7 82-66-6 Diphacinone 7 7726-95-6 Bromine 7

46 Journal of Chemical Health & Safety, January/February 2010 Table 2 (Continued ) CAS #a Chemical name Ref.b CAS #a Chemical name Ref.b 83-12-5 Phenindione 14 7733-02-0 Zinc sulfate 11 83-79-4 Rotenone 7 7738-94-5 Chromic acid 12 84-17-3 Dienestrol 14 7757-82-6 Sodium sulfate 7 84-66-2 Diethyl phthalate 12 7757-83-7 Sodium sulfite 7 84-74-2 Di-n-butyl phthalate 6,10–12 7758-19-2 Sodium chlorite 10 84-75-3 Di-n-hexyl phthalate 6 7758-97-6 Lead chromate 7,11,12 85-00-7 Diquat dibromide 7 7758-98-7 Copper (II) sulfate 7 85-68-7 Butyl benzyl phthalate 6,7 7768-81-4 Nickel (II) sulfate 7 86-22-6 Brompheniramine 14 7774-29-0 Mercuric iodide 6,7,10,14 86-50-0 Azinphos methyl 7 7775-11-3 Sodium chromate 7 87-51-4 3-Indoleacetic acid 10 7778-50-9 Potassium dichromate 7,12 87-86-5 Pentachlorophenol 7 7778-54-3 Calcium hypochlorite 7 88-05-1 Aminomesitylene 7 7779-88-6 Zinc nitrate 7 88-19-7 2-Toluenesulfonic acid 10 7782-44-7 Oxygen 7,10 88-72-2 2-Nitrotoluene 11 7782-49-2 Selenium 7,12 88-85-7 Dinoseb 6,7,10,14 7782-55-5 Chlorine 7 90-43-7 2-Phenylphenol 7 7782-61-8 Ferric nitrate 7 91-20-3 Naphthalene 7 7783-06-4 Hydrogen sulfide 7 91-81-6 Tripelennamine 14 7783-07-5 Hydrogen selenide 7 92-93-3 4-Nitrobiphenyl 7 7783-20-2 Ammonium sulfate 7 93-76-5 2,4,5-T 10,12 7783-70-2 Antimony pentafluoride 7 93-79-8 2,4,5-T butyl ester 10 7784-34-1 Arsenic trichloride 7,12 94-20-2 Chlorpropamide 14 7784-42-1 Arsine 7,12 94-36-0 Benzoyl peroxide 7 7784-46-5 Sodium arsenite 7,10 94-75-7 2,4-D 7,10,12,14 7785-87-7 Manganese sulfate 7 94-80-4 2,4-D butyl ester 10 7786-34-7 Mevinphos 7 94-82-6 2,4-D butyric acid 6 7787-36-2 Barium permanganate 12 95-80-7 2,4-Diaminotoluene 10 7789-00-6 Potassium chromate 7 96-09-3 Epoxyethylbenzene 10 7789-06-2 Strontium chromate 12 96-12-8 1,2-Dibromo-3-chloropropane 10,12,14 7789-12-0 Sodium dichromate 7 96-24-2 Chlorhydrin 10 7789-23-3 Potassium fluoride 7 96-31-1 1,3-Dimethylurea 10 7789-75-5 Calcium fluoride 7 96-45-7 Ethylene thiourea 6,10,12,14 7791-23-3 Selenium oxychloride 7 97-23-4 Dichlorophene 6 8001-35-2 Toxaphene 7,10 97-77-8 Disulfiram 10,14 8001-54-5 Alkyl dimethylbenzyl 7 ammonium chloride 98-83-9 a-Methyl styrene 7 8002-05-9 Crude oil 7 98-95-3 Nitrobenzene 7,12 8002-43-5 Soya lecithin 7 99-65-0 1,3-Dinitrobenzene 6 8006-61-9 Gasoline 7,14 99-66-1 Valproic acid 6,7,14 8006-64-2 Turpentine oil 7 95-80-7 Toluene 2,4-diamine 14 8008-20-6 Kerosene 7 100-25-4 1,4-Dinitrobenzene 6 8018-01-7 Mancozeb 12 100-40-3 4-Vinyl cyclohexene 11,12 8052-41-3 Stoddard solvent 7 100-41-4 Ethylbenzene 7 8063-07-8 Kanamycin 14 100-42-5 Styrene 7,10 8064-35-5 Methyl metiram 10 100-44-7 Benzyl chloride 7 9002-68-0 Menotropins 6,14 100-51-6 Benzyl alcohol 7 9003-20-7 Polyvinyl acetate 7 101-77-9 4,4-Methylenedianiline 7 9006-42-2 Metiram 6 101-84-8 Phenyl ether 7 9011-14-7 Polymethylmethacrylate 7 102-71-6 Triethanolamine 7 10024-97-2 Nitrous oxide 7,10–12 104-68-7 Diethylene glycol monophenyl ether 12 10028-15-6 Ozone 7 104-76-7 2-Ethyl-1-hexanol 10 10031-30-8 Granular triple superphosphate 7 106-46-7 1,4-Dichlorobenzene 10 10031-43-3 Copper (II) nitrate 7 106-87-6 Vinyl cyclohexene dioxide 11,12 10034-85-2 Hydriodic acid 14 106-88-7 1,2-Butylene oxide 7 10042-76-9 Strontium nitrate 7 106-89-8 Epichlorohydrin 6,10–12,14 10043-35-3 Boric acid 7,10,12

Journal of Chemical Health & Safety, January/February 2010 47 Table 2 (Continued ) CAS #a Chemical name Ref.b CAS #a Chemical name Ref.b 106-93-4 Ethylene dibromide 6,7,10,12,14 10045-94-0 Mercuric nitrate 6,10,12,14 106-94-5 1-Bromopropane 6,11,12 10048-95-0 Sodium arsenate 7,10 106-99-0 1,3-Butadiene 6,10,12,14 10049-04-4 Chlorine dioxide 10 107-02-8 Acrolein 7,10 10099-74-8 Lead nitrate 7,10 107-05-1 Allyl chloride 7,10 10102-18-8 Sodium selenite 10 107-06-2 Ethylene dichloride 7 10102-20-2 Sodium tellurite 7 107-13-1 Acrylonitrile 12 10102-44-0 Nitrogen dioxide 7,10 107-15-3 Ethylenediamine 7 10103-62-5 Calcium arsenate 7 107-16-4 Formaldehyde cyanohydrin 7 10108-64-2 Cadmium chloride 10,12 107-21-1 Ethylene glycol 7,10 10118-76-0 Calcium permanganate 12 107-98-2 Propylene glycol monomethyl ether 12 10124-36-4 Cadmium sulfate 7,12 108-03-2 1-Nitropropane 7 10124-50-2 Potassium arsenite 7 108-05-4 Vinyl acetate 7 10141-05-6 Cobalt (II) nitrate 7 108-10-2 Methyl isobutyl ketone 10 10192-30-0 Ammonium bisulfite 7 108-65-6 Propylene glycol methyl 7 10232-92-5 Butyronitrile 10 ethyl ether acetate 108-83-3 Toluene 6,7,10–12,14 10265-92-6 Methamidophos 7 108-90-7 Chlorobenzene 10 10294-34-5 Boron trichloride 7 108-91-8 Cyclohexylamine 10 10294-40-3 Barium chromate 7 108-94-1 Cyclohexanone 7,10 10377-60-3 Magnesium nitrate 7 108-95-2 Phenol 7,10 10415-75-5 Mercurous nitrate 6,10,12,14 109-59-1 2-Isopropoxyethanol 12 10418-03-8 Stanozolol 14 109-77-3 Malononitrile 7 10453-86-8 Resmethrin 6 109-79-5 n-Butyl mercaptan 12 10605-21-7 2-Benzimidazolecarbamic acid, 10 methyl ester 109-86-4 Ethylene glycol methyl ether 6,7,10–12,14 11056-06-7 Bleomycin 14 109-89-7 Diethylamine 7 11096-82-6 Aroclor 1260 10 109-99-9 Tetrahydrofuran 7,10 11097-69-1 Chlorodiphenyl (54% chlorine) 10,12 (Aroclor 1254) 110-13-4 2,5-Hexanedione 10 11406-87-2 Zileuton 6 110-46-3 Amyl nitrate 7 12002-03-8 Paris green 7 110-49-6 Ethylene glycol 6,7,10–12,14 12008-41-2 Disodium octaborate 7 monopropyl ether tetrahydrate 110-54-3 Hexane 7,10 12122-67-7 Zineb 12 110-71-4 Ethylene glycol dimethyl ether 11 12125-02-9 Ammonium chloride 7 110-80-5 Ethylene glycol ethyl ether 6,7,10–12,14 12427-38-2 Maneb 10,12 110-86-1 Pyridine 7 12674-11-2 Aroclor 1016 10 110-89-4 Piperidine 7 12709-98-7 Molybdate lead chromate 7 111-15-9 2-Ethoxyethyl acetate 10,12 12789-03-6 Chlordane 7 111-15-9 Ethylene glycol 6,7,10–12 13010-47-4 Lomustine 6,14 monoethyl ether acetate 111-46-6 Diethylene glycol 7,10 13071-79-9 Terbufos 7 111-69-3 Adiponitrile 7 13121-70-5 Cyhexatin 6 111-76-2 Ethylene glycol butyl ether 7,10,12 13171-21-6 Phosphamidon 7 111-77-3 Methoxyethoxy ethanol 7,10 13292-46-1 Rifampin 6 111-90-0 Diethylene glycol monoethyl ether 12 13311-84-7 Flutamide 6,14 111-90-5 2-Ethoxyethoxy ethanol 7 13410-01-0 Sodium selenate 7,10 111-96-6 Diethylene glycol dimethyl ether 10,12 13463-39-3 Nickel carbonyl 6,7,10,12 112-07-2 2-Butoxyethyl acetate 12 13530-65-9 Zinc chromate 7,12 112-14-1 Octyl acetate 7 13614-98-7 Minocycline 6,14 112-24-3 Triethylenetetramine 10 13647-35-3 Trilostan 6,14 112-27-6 Triethylene glycol 10 13718-26-8 Sodium metavanadate 7 112-30-1 Decanol 7 13765-19-0 Calcium chromate 12 112-34-5 Diethylene glycol monobutyl ether 12 13838-16-9 Enflurane 10,12

48 Journal of Chemical Health & Safety, January/February 2010 Table 2 (Continued ) CAS #a Chemical name Ref.b CAS #a Chemical name Ref.b 112-49-2 Triethylene glycol dimethyl ether 10 13909-09-6 1-(2-Chloroethyl)-3- 6 methylcyclohexyl- 1-nitrosourea 112-59-4 Diethylene glycol monohexyl ether 12 14028-44-5 Amoxapine 6 113-15-5 Ergotamine 14 14307-35-8 Lithium chromate 7 113-48-4 n-Octyl bicycloheptene 7 14484-64-1 Ferbam 11,12 dicarboximide 114-26-1 Propoxur 7,10 14807-96-6 Talc 7 115-09-3 Chloromethyl mercury 10 14808-60-7 Silica, crystalline 7 115-29-7 Endosulfan 7 14977-61-8 Chromyl chloride 12 115-38-8 Mephobarbital 14 15263-52-2 Cartap 10 115-67-3 Paramethadione 6,14 15475-56-6 Methotrexate sodium 6,14 116-06-3 Aldicarb 7 15663-27-1 Cisplatin 14 116-14-3 Tetracycline HCl 6 15687-27-1 Ibuprofen 14 117-37-3 Anisindione 6,14 16752-77-5 Methomyl 7 117-81-7 Di(2-ethylhexyl) phthalate 14 16893-85-9 Sodium silicofluoride 7 117-81-7 Dioctyl phthalate 6,7,10,12 16919-19-0 Ammonium silicofluoride 7 118-74-1 Hexachlorobenzene 6,10,14 16961-83-4 Hydrofluorosilicic acid 7 120-36-5 Propionic acid 10 17086-28-1 Doxycycline monohydrate 6 120-97-8 Dichlorphenamide 6 17230-88-5 Danazol 6,14 121-14-2 2,4-Dinitrotoluene 6,7,14 17702-57-7 Formparanate 7 121-69-7 N,N-Dimethylaniline 7 17804-35-2 Benomyl 6,7,10–12 121-75-5 Malathion 7 18378-89-7 Plicamycin 6,14 121-95-5 Carbarson 14 18883-66-4 Streptozocin 6,14 122-14-5 Fenitrothion 7 18972-56-0 Magnesium silicofluoride 7 122-34-0 Simazine 7 19044-88-3 Oryzalen 14 123-31-9 Hydroquinone 7 19210-06-1 Zinc dithiophosphate 7 123-39-7 N-Methyl formamide 10 19287-45-7 Diborane 7 123-86-4 n-Butyl acetate 7 19624-22-7 Pentaborane 7 123-91-1 Dioxane 7 19666-30-9 Oxadiazon 6 124-38-9 Carbon dioxide 7,10 19774-82-4 Amiodarone 6,14 124-65-2 Sodium cacodylate 7 19774-82-4 Amiodarone HCl 14 125-02-0 Prednisolone sodium phosphate 6 20354-26-1 Methazole 6 125-33-7 Primidone 14 20830-75-5 Digoxin 7 125-84-8 Aminoglutethimide 6,14 20830-81-3 Daunorubicin 14 126-07-8 Amudane 10 21041-95-2 Cadmium hydroxide 7,12 126-99-8 b-Chloroprene 12 21609-90-5 Leptophos 7 127-00-4 1-Chloro-2-propanol 12 21679-14-1 Fludarabine 14 127-07-1 Hydroxyurea 6,14 21725-46-2 Cyanazine 6 127-18-4 Perchloroethylene 7,10,12,14 21829-25-4 Nifedipine 6 127-18-4 Tetrachloroethylene 12 21908-53-2 Mercuric oxide 6,7,10,14 127-19-5 N,N-Dimethylacetamide 10–12 22224-92-6 Fenamiphos 7 127-48-0 Trimethadione 6,14 22232-54-8 Carbamizole 14 128-03-0 Potassium dimethyldithiocarbamate 6 22494-42-4 Diflunisal 6,14 128-04-1 Sodium 6 22967-92-6 Methyl mercury 6,10,14 dimethyldithiocarbamate 129-06-6 Warfarin sodium 7 23092-17-3 Halazepam 6,14 130-95-0 Quinine 14 23214-92-8 Doxorubicin HCl 6,14 131-11-3 Dimethylphthalate 7,12 23422-53-9 Formetanate HCl 7 131-52-2 Sodium pentachlorophenate 7 23541-50-6 Daunorubicin HCl 6,14 133-06-2 Captan 10,12 23564-05-8 Thiophanate methyl 6 133-07-3 Folpet 10 24017-47-8 Triazofos 7 134-62-3 N,N-Diethyl-m-toluamide 7 24390-14-5 Doxycycline hyclate 6 137-26-8 Thiram 10 24602-86-6 Morpholine 10 137-30-4 Ziram 12 25057-89-0 Bentazon 7 137-42-8 Metham sodium 6 25122-46-7 Clobetasol propionate 6

Journal of Chemical Health & Safety, January/February 2010 49 Table 2 (Continued ) CAS #a Chemical name Ref.b CAS #a Chemical name Ref.b 138-93-2 Disodium 6,14 25168-26-7 2,4-D isooctyl ester 10 cyanodithioimidocarbonate 140-88-5 Ethyl acrylate 7 25321-14-6 Dinitrotoluene 10–12 141-43-5 Ethanolamine 7 25322-68-3 Polyethylene glycol 7 141-78-6 Ethyl acetate 7 25586-43-0 Chloronaphthalene 7 142-59-6 Nabam 6 25614-03-3 Bromocriptine 14 143-24-8 Tertraglyme 10 25655-41-8 Povidone/iodine 14 143-33-9 Sodium cyanide 7 25812-30-0 Gemfibrozil 6,14 143-50-0 Kepone 6,10,12,14 26172-55-4 5-Chloro-2-methyl-4- 7 isothiazolin-3-one HCl 143-67-9 Vinblastine sulfate 6,14 26447-14-3 Cresyl glycidyl ether 7 143-81-7 Butabarbital sodium 6 26471-62-5 Toluene diisocyanate 7 144-49-0 Fluoroacetic acid 7 26571-11-9 Nonoxynol-9 7 144-62-7 Oxalic acid 7 26628-22-8 Sodium azide 7,12 147-94-4 Cytarabine 6,14 26644-46-2 Triforine 6 148-79-8 Mintezol 10 26907-37-9 Thiadiazole 10 148-82-3 Melphalan 6,10,14 27176-87-0 Dodecylbenzenesulfonic acid 7 149-57-5 2-Ethylhexanoic acid 11,12 28657-80-9 Cinoxacin 14 150-19-6 Resorcinol methyl ether 10 28772-56-7 Bromadiolone 7 151-18-8 3-Aminopropionitrile 10 28911-01-5 Triazolam 6,14 151-38-2 Methoxyethylmercuric acetate 7 28981-97-7 Alprazolam 6,14 151-50-8 Potassium cyanide 7 29122-68-7 Atenolol 6,14 151-56-4 Ethyleneimine 7 29767-20-2 Teniposide 6,14 151-67-7 Halothane 6,10,12 29975-16-4 Estazolam 14 152-16-9 Octamethylpyrophosphoramide 7 30560-19-1 Acephate 7 154-42-7 Thioguanine 6,14 31431-39-7 Mebendazole 6 154-93-8 Bischloroethyl nitrosourea 6,14 32222-06-3 Calcitriol 14 205-46-0 Oxytetracycline HCl 6,14 32986-56-4 Tobramycin 14 297-76-7 Ethynodiol acetate 14 33069-62-4 Pacitaxel 6,14 298-00-0 Methyl parathion 7 33089-61-1 Amitraz 6 298-02-2 Phorate 7 33286-22-5 Diltiazem 6 298-46-4 Carbamazepine 6,14 33419-42-0 Etoposide 6,14 298-81-7 Methoxsalen 14 34031-32-8 Auranofin 6 299-84-3 Ronnel 10 34590-94-8 Dipropylene 12 glycol methyl ether 301-04-2 Lead acetate 7,10 35554-44-0 Fungaflor 10 301-12-2 Oxydemeton methyl 6,14 36501-84-5 Lead diamyldithiocarbamate 7 302-01-2 Hydrazine 7,10,12 36735-22-5 Quazepam 6,14 302-79-4 trans-Retinoic acid 6,14 36791-04-5 Ribavirin 6 303-45-7 Gossypol 10 37517-28-5 Amikacin 6,14 305-03-3 Chlorambucil 6,7,14 37953-07-4 Carbendazim 14 309-00-2 Aldrin 7,10 38194-50-2 Sulindac 6,14 309-43-3 Secobarbital 6 38260-01-4 Trientine HCl 6 314-40-9 Bromacil 6,7 39300-45-3 Dinocap 6,10,12,14 315-18-4 Mexacarbate 7 41340-25-4 Etodolac 6,14 315-37-7 Testosterone enanthate 6,14 41575-94-4 Carboplatin 6,14 329-89-5 Aminonicotinamide 10 43121-43-3 Triadimefon 6 330-54-1 Diuron 7 49842-07-1 Tobramycin sulfate 6,14 330-55-2 Linuron 6 50471-44-8 Vinclozolin 6 333-20-0 Potassium thiocyanate 7 50782-69-9 VX 7 333-41-5 Diazinon 7,10 51338-27-3 Dichlofop 6 359-06-8 Fluoroacetyl chloride 7 53469-21-9 Chlorodiphenyl 12 (42% chlorine) 364-98-7 Diazoxide 6,14 53910-25-1 Pentostatin 6,14 366-70-1 Procarbazine HCl 6,14 54350-48-0 Etretinate 6,14 371-62-0 Ethylene fluorohydrin 7 54910-89-3 Fluoxetine 7

50 Journal of Chemical Health & Safety, January/February 2010 Table 2 (Continued ) CAS #a Chemical name Ref.b CAS #a Chemical name Ref.b 379-79-3 Ergotamine tartrate 6,7 54965-24-1 Tamoxifen citrate 6,14 406-90-6 Fluroxene 12 55079-83-9 Acitretin 14 427-51-0 Cyproterone 14 56391-57-2 Netilmicin 6,14 434-03-7 Ethisterone 14 57109-90-7 Clorazepate dipotassium 6,14 434-07-1 Oxymetholone 6,14 57117-31-4 Dibenzofuran 10 434-22-0 Nandrolone 14 57852-57-0 Idarubicin HCl 6,14 435-97-2 Phenprocoumon 6,14 58138-08-2 Tridiphane 10 438-41-5 Chlordiazepoxide 14 58536-65-1 Firemaster BP-6 10 439-14-5 Diazepam 6,14 59122-46-2 Misoprostal 6,14 443-48-1 Metronidazole 14 59467-96-8 Midazolam HCl 6,14 446-86-6 Azathioprine 6,14 60124-79-0 Phencyclidine 14 460-19-5 Cyanogen 7 61788-33-8 Kanechlor 500 10 463-58-1 Carbonyl sulfide 7 61790-14-5 Lead naphthalene 7 465-73-6 Isodrin 7 62571-86-2 Captopril 14 474-25-9 Chenodiol 6,14 63148-62-9 Polydimethylsiloxane 7 497-19-8 Sodium carbonate 7 64070-11-7 Antimony potassium tartrate 7 502-39-6 Methyl mercuric dicyanamide 7 64742-95-6 Naphtha 7,10 505-60-2 Mustard gas 7,10 64902-72-3 Chlorsulfuron 6 506-61-6 Potassium silver cyanide 7 65807-02-5 Goserelin 6,14 506-78-5 Cyanogen iodide 7 66085-59-4 Nimodipine 6 508-68-3 Cyanogen bromide 7 66441-23-4 Fenoxaprop 6 509-14-8 Tetranitromethane 7 66852-54-8 Halobetasol propionate 6 512-56-1 Trimethylphosphate 10 67485-29-4 Hydra methylnon 6 530-75-6 Acetylsalicylic acid 6,7,14 67746-08-1 Polymerized linseed oil 7 534-13-4 Dimethyl-2-thiourea 10 67774-32-7 Polybrominated biphenyl 6,10,12 536-33-4 Ethionamide 6 68081-81-2 Sodium dodecyl 7 benzenesulfonate 538-07-8 Bis(2-chloroethyl)ethylamine 12 68476-30-2 Fuel oil #2 7 541-25-3 Lewisite 7,10 68515-49-1 Diisodecyl phthalate 6 541-73-1 1,3-Dichlorobenzene 7 68603-83-8 Lead carboxylate 7 542-90-5 Ethyl thiocyanate 7 69409-94-5 Fluvalinate 6 543-90-8 Cadmium acetate 7,12 69610-10-2 N-Methyl-3,4- 14 methylenedioxyamphetamine 546-88-3 Acetohydroxamic acid 6,7,14 69806-50-4 Fluazifop butyl 6 548-00-5 Ethyl biscoumacetate 14 70458-96-7 Norfloxacin 14 549-18-8 Amitryptyline 14 70476-82-3 Mitoxantrone 6,14 554-13-2 Lithium carbonate 6,14 70657-70-4 2-Methoxypropyl acetate 10 555-77-1 Tris(2-chloroethyl)amine 12 71195-58-9 Alfentanil 14 556-52-5 Glycidol 10 73590-58-6 Omeprazole 14 556-64-9 Methyl thiocyanate 7 74381-53-6 Leuprolide 6,14 561-27-3 Heroin 7,14 75330-75-5 Lovastatin 6,14 564-25-0 Doxycycline 6,14 75847-73-3 Enalapril 14 569-57-3 Chlorotrianisene 14 76547-98-3 Lisinopril 14 591-78-6 2-Hexanone 11,12 76578-14-8 Quizalofop-ethyl 6 592-01-8 Calcium cyanide 7 76712-82-8 Histrelin acetate 6,14 592-41-6 1-Hexene 12 79217-60-0 Cyclosporin 14 592-87-0 Lead II thiocyanate 12 79902-63-9 Simvastin 14 595-33-5 Megestrol acetate 6,14 80474-14-2 Fluticasone propionate 6 598-78-9 2-Chloropropionic acid 11,12 81103-11-9 Clarithomycin 6 604-75-1 Oxazepam 6,14 81131-70-6 Pravastatin sodium 6,14 606-20-2 2,6-Dinitrotoluene 6,14 82410-32-0 Ganciclovir sodium 6,14 624-83-9 Methyl isocyanate 7,10,12,14 82419-36-1 Ofloxacin 14 628-63-7 Amyl acetate 7 82952-64-5 Trimetrexate glucuronate 6,14 629-14-1 Ethylene glycol diethyl ether 10 84371-65-3 Mifepristone 14 630-08-0 Carbon monoxide 6,7,10,12,14 85441-61-8 Quinapril 14 630-60-4 Ouabain 7 85721-33-1 Ciprofloxin 14

Journal of Chemical Health & Safety, January/February 2010 51 Table 2 (Continued ) CAS #a Chemical name Ref.b CAS #a Chemical name Ref.b 630-93-3 Phenytoin sodium salt 7,14 86168-78-7 Sermorelin acetate 6 637-03-6 Phenyl arsine oxide 12 86220-42-0 Nafarelin acetate 6,14 637-92-3 Ethyl tert-butyl ether 12 86541-75-5 Banazepril 14 638-21-1 Phenylphosphine 10–12 87333-19-5 Ramipril 14 639-58-7 Triphenyltin chloride 7 88671-89-0 Myclubutanil 6 645-05-6 Hexamethylmelamine 6,11,14 93957-54-1 Fluvastatin 14 646-06-0 1,3-Dioxolane 10,12 94088-85-4 Doxycycline calcium 6 665-66-7 Amanatadine HCl 6 97048-13-0 Urofollitropin 6,14 671-16-9 Procarbazine 14 98048-97-6 Fosinopril 14 680-31-9 Hexamethylphosphoramide 6,14 98079-51-7 Lomefloxacin 14 684-16-2 Hexafluoroacetone 10,12 98319-26-7 Finasteride 14 684-93-5 Nitrosomethylurea 10,14 100986-85-4 Levofloxacin 14 732-11-6 Phosmet 10 104227-87-4 Famciclovir 14 759-73-9 Ethylnitrosourea 14 112811-59-3 Gatifloxacin 14 759-94-3 Ethyl dipropylthiocarbamate 6 113852-37-2 Cidofovir 6,14 786-19-6 Carbophenothion 7 121181-53-1 Filgrastim 6 789-02-6 o,p-DDT 6,10,14 CAS #a Chemical name Ref.b Mixtures 35189-28-7/57-63-6 Norgestimate/ethinyl estradiol 14 6533-00-2/57-63-6 Norgesrtel/ethinyl estradiol 14 68-22-4/57-63-6 Norethisterone/ethinyl estradiol 6 68-22-4/72-33-3 Norethisterone/mestranol 6 NA Aminoglycosides 6 NA Amphetamines 14 NA Anabolic steroids 6,14 NA Anesthetic gases 14 NA Angiotensin converting enzyme inhibitors 6,14 NA Antihistamines 14 NA Barbiturates 6,14 NA Barium soluble salts 7 NA Benzodiazepines 6,14 NA Betadine 14 NA Borates, anhydrous 12 NA Bromides (anticonvulsant/sedative) 14 NA Bumetanide 14 NA Butanol 7,10 NA Butiphos 14 NA Butylated urea formaldehyde 7 NA Cadmium compounds 12 NA Chromates 12 NA Chromium compounds 12 NA Chromium hexavalent salts 7 NA Ciguatoxin 14 NA Clay 7 NA Clofibrate 14 NA Coal tar 7,10,12 NA Conjugated estrogens 6,14 NA Creosote 7 NA 4,6-Dinitro-o-cresol and salts 7 NA Dioxins 7 1 NA Dow Separan AP30 synthetic polymer 7 NA Epoxy resin 7 NA Fluoride 7 NA Fluorosilicate ion 7

52 Journal of Chemical Health & Safety, January/February 2010 Table 2 (Continued ) CAS #a Chemical name Ref.b NA Glycol ethers 10,12 NA Heat 7 NA Jet fuel 7 NA Lead, inorganic compounds 6 NA Light ends (liquid) 7 NA Manganese, inorganic compounds 10 NA Marijuana 14 NA MCPP/2,4-D 7 NA Mercury, alkyl compounds 6,7,10,12,14 NA Mercury, aryl compounds 10,12,14 NA Mercury, inorganic compounds 10,14 NA Methoxsalen 14 NA Muscovite mica 7 NA Natural gas 7 NA Nickel compounds 10,12 NA Nitrates 12 NA Nitriles 12 NA Nitrites 12 NA PCB’s 7,10 NA Phosphate rock 7 NA Phthalate esters 12 NA Polycyclic aromatic hydrocarbons 12 NA PVC resin 7 NA Pyrethrins 7 NA Retinol esters 14 NA Selenium compounds 12 NA Sulfonamides 14 NA Tellurium and compounds 7,12 NA Trichloroethane 7 NA Vitamin D 7 NA Zinc salts of dialkylphosophorodithiotic acid 7 a Chemical Abstracts Services Registry Number. b References taken from text. References are: 6 = California Proposition 65; 7 = Reprotext; 10 = Jankovic and Drake; 11 = ACGIH; 12 =NIH (Haz-Map); 14 = US Navy/USMC.

Journal of Chemical Health & Safety, January/February 2010 53