Eukaryotic mRNA Processing
Session 1 RNA/PROTEIN INTERACTIONS TUESDAY 8/20/2013, 7:30 PM J. Doudna / A. Zahler # lname Title Talk Length 1 Montemayor Core structure of the yeast U6 snRNP at 1.8 Å resolution reveals an extensive and unusual RNA- 12 protein interface 2 Loerch The CAPERα UHM provides a potential means for alternative splice site regulation 12 3 Robertson Specificity of Rna15-RNA Interactions at 3’-end processing sites 12 4 Wang An RNA topoisomerase works with the Fragile X syndrome protein to promote synapse formation 12
5 Kuroyanagi Multi-domain protein LST-3 regulates pre-mRNA transcription and alternative splicing in C. 12 elegans 6 Campbell Breaking the code of RNA recognition by PUF domain proteins 12 7 Cook A compendium of RNA binding motifs for decoding gene regulation 12 8 Quesnel-Vallières Essential roles for the neural-specific splicing regulator nSR100/SRRM4 in the developing 12 mouse nervous system 9 Damianov RBFox splicing regulation through recruitment to non-UGCAUG sequence elements 12 10 Yarosh GSK3/TRAP150-mediated regulation of the multifunctional RNA-binding protein PSF 12
Session 2 RNP ASSEMBLY AND FUNCTIONS WEDNESDAY 8/21/2013, 9:00 AM R. Lührmann / M. Jurica # lname Title Talk Length 11 Liang The DEAD-box ATPase Prp5 mediates splicing fidelity control by counteracting tri-snRNP binding 12
12 Beggs Cwc21p regulates branch site usage in meiotic splicing 12 13 Semlow An open conformation of the spliceosome promotes catalysis and proofreading 12 14 O'Keefe Prp16 remodelling of helix I during the two steps of pre-mRNA splicing is carried out through the 12 Nineteen Complex protein Cwc2 15 Sauer Interactions of U6 snRNA within the catalytic center of the spliceosome—Modulation of pre- 12 mRNA splicing by U6-like exon sequences act 16 Luehrmann 3D Cryo-EM structure of the yeast activated spliceosome (B ) and localisation of 12 functionally important regions 17 Effenberger Features of the anti-tumor drug pladienolide B mediating cellular responses are also required for 12 splicing inhibition 18 Akerman Differential connectivity of splicing activators and repressors to the human spliceosome 12 19 Mao The role of the exon junction complex in brain development 12 20 Lasda An RNA element that activates trans-splicing of polycistronic pre-mRNAs of operons 12
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Session 3 CO-TRANSCRIPTIONAL RNA PROCESSING WEDNESDAY 8/21/2013, 2:00 PM N. Proudfoot / T. Johnson # lname Title Talk Length 21 Shah Non-coding transcription brings RNAi to repress nutrient uptake genes in fission yeast 12 22 Merkhofer SAGA-mediated acetylation regulates Prp5 activity in pre-mRNA splicing 12 23 Guthrie Genetic interaction mapping reveals a role for the SWI/SNF nucleosome remodeler in early steps 12 of splicing in fission yeast 24 Bentley Kinetic coupling—How transcription elongation rate affects mRNA processing 12 25 Larson Kinetic competition during the transcription cycle results in both co- and post-transcriptional 12 splicing at the same gene 26 Oh U1 snRNA bi-directionally regulates mRNA length, oncogenes expression and cancer cell 12 phenotype 27 Tian Systematic analysis of regulation of alternative cleavage and polyadenylation by 3’ end processing 12 and splicing factors 28 Cao Arginine methylation regulates widespread alternative polyadenylation 12 29 Garrido-Lecca Analysis of 3' end formation factor CstF recruitment to C. elegans genes 12 30 Devany Role of mRNA 3’ processing in the progression of the DNA damage response (DDR) 12
Session 4 POSTER SESSION I WEDNESDAY 8/21/2013, 7:30 PM
# lname Title Talk Length 81 Abdelhamid Multiplicity of caps in small RNAs 82 Adachi A novel semi-quantitive proteomic approach for identifying the critical proteins that regulate the fate of a specific mRNA 83 Adamia Aberrant splicing in AML patients could be induced by the modulated expression of splicing factors
84 Alipanahi Ramandi Computational splicing code—Implications of disease-associated genome variations 85 Anczukow Differential functions of splicing factors in breast-cancer initiation and metastasis 86 Anczukow Of splicing regulation by SRSF1 in breast cancer 87 Anthony Structural insight into 5' splice-site recognition by U1 snRNP and its regulation 88 Araki CLK inhibition induces cell growth inhibition and apoptosis in cancer cells through the modulation of pre-mRNA splicing 89 Ares Competition between pre-mRNAs for the splicing machinery drives global regulation of splicing
90 Arias Splicing of designer exons informs a biophysical model for exon definition
Page 2 of 12 91 Arribas-Layton The role of the RGG C-terminal domain of Lsm4 in mRNA decay 92 Asta RUMP, a Drosophila hnRNP M homolog, elicits nuclear 3'-to-5' and cytoplasmic 5'-to-3' decay of mRNA targets 93 Bahrami-Samani Probabilistic modeling and data integration to examine RNA-protein interactions 94 Balagopal Genome-wide studies identify novel targets of Bicoid during Drosophila development 95 Barash High-throughput predictions—From RNA splicing to protein 96 Bardina Role of RNA processing factor SFPQ and nuclear matrix protein MATR3 in post-transcriptional regulation of HIV-1 RNA 97 Bartok Transcriptional and post-transcriptional rewiring of the circadian transcriptional network in response to environmental perturbations 98 Batista Role of m6A RNA methylation in early development 99 Bechara RBM5, RBM6 and RBM10 differentially regulate NUMB alternative splicing to control cancer cell proliferation 100 Blech-Hermoni Effects of CELF1 knockdown on myofibril structure and function in cultured primary embryonic cardiomyocytes 101 Bolisetty RNA binding proteins regulate mod(mdg4) Trans-splicing in Drosophila 102 Boyne CstF-64 functions in regulating alternative polyadenylation during C2C12 myoblast differentiation
103 Bresson Polyadenylation controls nuclear RNA decay in mammalian cells 104 Brinegar Identifying the mechanism of CELF and MBNL paralogs’ reciprocal up-regulation 105 Brooks A pan-cancer analysis of transcriptome alterations associated with somatic mutations in U2AF35 reveals commonly altered splicing events and altered 3’ splice site sequence recognition 106 Burge Antagonism between MBNL and CELF proteins in the nucleus and cytoplasm 107 Burge Intrinsic RNA affinity spectra of RBFOX, MBNL and CELF proteins identifies secondary motifs and predicts in vivo binding and activity 108 Caputi SF2 down-regulates the activity of the viral transcriptional activator Tat 109 CERON MADRIGAL Exploring the role of cotranscriptional splicing in the autosomal dominant Retinitis pigmentosa disease 110 CERON MADRIGAL Genes of the lsm family conserved across the tree of life regulate cellular stress responses in C. elegans 111 Chang Tissue-specific posttranscriptional gene regulation by HuR controls angiogenesis nrb 112 Chen Methylation of p54 by CARM1 alters nuclear retention of mRNAs with 3′-UTR IRAlus 113 Cheng Linking splicing factors, alternative splicing, and EMT 114 Cieply A comprehensive and unbiased screen of RNA binding proteins to identify novel splicing factors
Page 3 of 12 115 Cole Transcriptome-wide RNA interaction profiling reveals physical and functional targets of hnRNP L in human T-cells 116 Collins Characterisation of TUT4-RNA binding 117 Conboy A dynamic alternative splicing program regulates gene expression during terminal erythropoiesis
118 Dalal Cellular functions and molecular targets of CELF6, an RNA binding protein mutated in a case with autism 119 Damgaard Abundant circular RNAs function as miRNA sponges 120 Davis-Turak Sequence signatures and transcriptional read-through favor co-transcriptional splicing genome- wide 121 Delforge Radiotherapy affects splicing in human mammary cancer cells 122 Desai (French) Comparison of D. melanogaster and C. elegans developmental stages, tissues and cells by modENCODE RNA-Seq data 123 Deshmukh Structure, dynamics and dsRNA binding of RDE-4 suggest mechanism of RNAi initiation in C. elegans 124 Despic Studies of pre-mRNA splicing competence in early zebrafish embryos 125 Di Giammartino RBBP6—Characterization of a new pre-mRNA 3’ end processing factor 126 Dichmann The alternative splicing regulator Tra2b is required for proper somitogenesis in Xenopus, and regulates splicing of a novel wnt11b splice form 127 Elkayam The making of a slicer—Activation of human Argonaute-1 128 Ennajdaoui Regulation of cellular adhesion and invasion by the oncofetal RNA binding IGF2BP3 129 Eshel Detection of genes and microRNA involved in sex determination in Nile tilapia (Oreochromis niloticus) 130 Faehnle The making of a slicer—Activation of human argonaute-1 131 Fasina Characterization of alternative polyadenylation of parvovirus minute virus of canine pre-mRNAs
132 Feng Regulation of alternative cleavage and polyadenylation (APA) by epileptic stimulation 133 Fontes Cytoplasmic RbFox1 antagonizes miRNA function in neurons 134 Fu ZFP36 family proteins regulate the stability of retinoblastoma protein mRNAs during serum- stimulated G0-S transition 135 Fursham Regulation of mRNA abundance by developmentally regulated switch in utilization of alternate 5’ splice sites 136 Gabriel Regulation of gene expression and alternative splicing by chemotherapy in vitro 137 Gallagher Rapid mRNA clearance of cyclic segmentation genes requires the nuclear hormone receptor gene pnrc2 and the spliceosomal component gene cdc5l 138 ge Evasion of nonsense-mediated mRNA decay by mRNAs with long 3’UTRs 139 Giallourakis Genome-wide analyses of N6-methyladenosine (m6A) modification during endoderm differentiation
Page 4 of 12 140 Gould Large-scale identification of RNA branch point sequences 141 Graveley Genome-wide identification of recursive splicing in Drosophila 142 Grozdanov Molecular roles of the testis-expressed cleavage stimulation factor-64, τCstF-64, involved in the 3′-end processing of mRNAs during mouse spermatogenesis 143 Gruber Transcriptional and translational profiles in stimulated T lymphocytes 144 Guilgur Fast and furious—Developmental constraint to pre-mRNA splicing during early embryonic development in Drosophila 145 Haque Identification of proteins recruited to translationally repressed mRNAs 146 Herissant Histone marks contribute to gene-specific spliceosome assembly and function 147 Hoskins Using colocalization single molecule spectroscopy to develop a quantitative framework for the early stages of spliceosome assembly 148 Hurt Global analyses of UPF1 binding and function reveal expanded scope of nonsense-mediated mRNA decay 149 Inada Linking the C terminal domain code of RNA polymerase II to modulating chromatin states in Schizosaccharomyces pombe 150 Indik The 5’ leader sequence dependent regulation of MMTV Envelope protein expression 151 Jerhammar Wig-1, a p53-induced regulator of mRNA stability 152 Kaida U2 snRNP is required for the phosphorylation of CTD Ser2 and efficient transcription elongation
153 Kakaradov Heterogeneity of RNA expression and A-to-I editing in single neurons 154 Kaminska Small virus, big problem—Why do we still need a drug for flu? 155 Kannan Intronic sequence elements impede exon ligation and trigger a discard pathway that yields functional telomerase RNA in fission yeast 156 Kim PSY—Polyadenylation shifting analysis for studying breast cancer 157 Kim Rbfox3-regulated alternative splicing of numb promotes neuronal differentiation during development 158 Kini The cytoplasmic poly(A) binding protein isoform, PABPC4, plays a critical role in erythroid differentiation 159 Kleiman CstF1 regulates the BRCA1/BARD1 ubiquitin (Ub) ligase activity resulting in chromatin remodeling during DNA damage response (DDR) 160 Kojima The ticking poly(A) tails time protein production—The circadian control of poly(A) tail length 161 Kress The NuA4 and Swr1 chromatin modification complexes are important for RNA splicing 162 Kuersten Development of methods and data analysis tools for deep sequencing ribosome protected mRNA fragments 163 Ladd Muscleblind-like 1 is necessary for normal heart valve formation and septation in vivo
164 Lahsaee Estradiol regulates PRP4K gene expression post-transcriptionally via its 3’ UTR
Page 5 of 12 165 Lambert Genome-wide study of the effects of chemotherapy on splicing in PBMC from B-cell chronic lymphoblastoid leukemia affected patients: preliminary data 166 Lecuyer Developmentally-regulated elimination of damaged nuclei via a Chk2-dependent mechanism of mRNA nuclear retention 167 Lee RNA binding protein, HuD regulates autophagosome formation by enhancing ATG5 expression
168 Lee Mbnl compound knockout models for studies on RNA processing and RNA-mediated disease mechanisms 169 Lee Integration of TRAP150-activated cryptic splicing with premature cleavage and polyadenylation
170 Lee Systems level analysis of alternative pre-mRNA splicing—The roles of RNA structure and RNA chaperone proteins
Session 5 MECHANISMS OF RNA SPLICING / GLOBAL ANALYSES AND EVOLUTION THURSDAY 8/22/2013, 9:00 AM M. Sattler / C. Guthrie # lname Title Talk Length 31 Echeverria Muscleblind-like 1 (MBNL1) activates splicing by enhancing U2AF65 binding across the exon, 12 promoting upstream intron removal 32 Mandler The hnRNPF/H-dependent alternative splicing pathway is controlled by the selective RNA-binding 12 protein QKI 33 Plocik Systematic dissection of Dscam alternative splicing dynamics mediated by RNA-binding 12 proteins 34 Wong Regulation of human telomerase splicing by RNA:RNA pairing 12 35 Younis Minor introns are embedded molecular switches regulated by highly unstable U6atac snRNA 12
36 Braunschweig Exploring the landscape of intron retention in vertebrate species 12 37 Tejedor Genome-wide RNAi screen and splicing functional network analysis link iron homeostasis and 12 alternative splicing regulation 38 Merkin Evolutionary analyses of alternative splicing and its regulation in mammals 12 39 Pleiss Lariat sequencing in a unicellular yeast identifies regulated alternative splicing of exons that are 12 evolutionarily conserved with humans 40 Hertel Silent effects of splicing—Conservation of splicing signals in coding exons 12
Session 6 RNA CELL BIOLOGY THURSDAY 8/22/2013, 2:00 PM A.G. Matera / M. Carmo-Fonseca # lname Title Talk Length 41 Gebauer Drosophila UNR acts as an RNA chaperone on roX2 non coding RNA and facilitates the 12 recruitment of MLE during X-chromosome dosage compensation 42 Machyna Coilin-RNA interactome identifies hundreds of mammalian snoRNAs that localize to Cajal bodies 12
Page 6 of 12 43 Fushimi Nuclear RBP FUS targets mitochondrial ATP synthase to impair mitochondrial function and 12 biogenesis 44 Schweizer Burguete Localization of microsatellite repeat RNAs 12 45 Eckhof Genomewide analysis of post-transcriptional gene regulation by the human IGF2BP3 (IMP3) 12 protein: role of IMP3 in ER-proximal mRNA localization 46 Carmo-Fonseca Imaging pre-mRNA splicing with single-molecule sensitivity 12 47 Rabani The genome-wide dynamic regulation of RNA splicing and editing in mammalian cells is revealed 12 by high-resolution sequencing of total and recently transcribed RNA 48 Dominguez Temporal control of alternative splicing is coordinated with the mammalian cell cycle 12 49 Kaempfer Splicing of human globin mRNA is controlled by activation of stress kinase PKR and 12 phosphorylation of translation initiation factor eIF2α 50 Gonzalez-Porta Transcriptome analysis of human tissues and cell lines reveals one dominant transcript per gene 12
Session 7 POSTER SESSION II THURSDAY 8/22/2013, 7:30 PM
# lname Title Talk Length 171 Li Study of alternative splicing in single cells 172 Li Diverse and significant impacts of alternative cleavage and polyadenylation of mRNA on translation
173 Licatalosi Ptbp2 is essential for germ cell development in male mice and exhibits tissue-specific patterns of RNA binding 174 lin A novel class of structured intron illustrates a function for expansions of simple repeats in vertebrate gene expression 175 Lin TALEN-mediated editing of microRNA and RNA processing genes in human cell lines 176 Liu Structurally diverse small molecule activators of the mammalian pre-mRNA 3' cleavage reaction
177 Ma Molecular mechanism of small non-coding RNAs degradation by SDN1 178 Mallory Control of CELF2 in T cell activation and its regulation of LEF1 alternative splicing 179 Martinez T cell activation and the JNK pathway—From signaling to splicing and back 180 Matera A histone gene replacement platform for studying the epigenetic regulation of pre-mRNA splicing and metazoan development 181 Mayeda Switching of hnRNP L to hnRNP LL converts PTB-mediated exon exclusion to inclusion in a congenital myasthenic syndrome 182 Mirza Human breast milk derived exosomes from type 1 diabetic mothers deliver functional RNA to the infant? 183 Missan Roles for integrin α3β1 in regulating MMP9 mRNA stability through alternative transcript generation 184 Morris A compendium of RNA binding motifs for decoding gene regulation Page 7 of 12 185 Muchardt A global impact of chromatin factors on splicing 186 Mukherjee Identification of NCK1 as the scaffold for assembly of the cytoplasmic capping enzyme complex
187 Müller-McNicoll SR proteins and their roles in mRNA export in vivo 188 Munschauer Protein occupancy profiling globally maps putative cis-regulatory mRNA regions 189 Namer Translation initiation factor eIF2α phosphorylation controls splicing of tumor necrosis factor mRNA 190 Neymotin Global determinants of variation in mRNA decay rates 191 Nguyen Splicing regulation of alternative exon 23a of the neurofibromatosis type 1 pre-mRNA by DBIRD complex 192 Nissen A Role for the histone variant H2A.Z and the SWR1 nucleosome remodeling complex in pre- mRNA splicing in fission yeast 193 Nussbacher Mapping N6-methyladenosine and identifying its role in mRNA processing during neural differentiation 194 Nwokeoji Analysis of spliceosome protein-snRNA interactions and assembly in yeast by tandem affinity purification-mass spectrometry approach 195 Nwokeoji Capturing the events of protein-snRNA compositional changes in yeast pre-spliceosome U2 snRNP and the spliceosome complex B - B-act transitory events using tandem affinity purification- tandem mass spectrometry approach 196 Oberdoerffer The regulation of alternative pre-mRNA splicing through dynamic DNA methylation 197 Ohe Sequence-specific RNA-binding of HMGA1a plays a role in Estrogen receptor-negative breast carcinoma 198 Oren The role of UPR activation in human health and diseases 199 Pak CDK11 in transcription elongation and co-transcriptional processing of nascent transcripts 200 Pawellek GRE010 - a new splicing modifier 201 Peart Defining the cis regulatory elements of Dux4 mRNA 3'end formation 202 Perales lin-67 regulates developmental timing in C. elegans 203 Pereira Characterization of A2bp1 in S2 cells of Drosophila 204 Pilkington The identification of a novel posttranscriptional regulatory element in gamma retroviruses 205 Pitchiaya Single molecule systems biology reveals dynamic and diverse modes of microRNP–processing body interactions 206 Pratt CLIPper (CLIP Peak EnRichment)—Methodology for understanding different binding patterns of RNA binding proteins 207 Ragle Tissue-specific alternative splicing in C. elegans germ-line and somatic tissues 208 Rao 17β-estradiol regulates the biosynthesis of mature microRNA at multiple levels in the aged female rat hippocampus 209 Rosa de Araujo Genomics and biological analyses define novel regulatory roles for the RNA binding protein Musashi1 in gliomagenesis
Page 8 of 12 210 Rossbach Genome-wide crosslinking-immunoprecipitation analysis reveals novel regulatory roles of hnRNP L 211 Sanford Frac-seq reveals isoform-specific recruitment to polyribosomes 212 Schaal HEXploring of the HIV-1 genome allows landscaping of new potential splicing regulatory elements
213 Schwer Structure-function analysis of the 5' end of yeast U1 snRNA highlights genetic interactions with the Msl5•Mud2 branchpoint binding complex and other spliceosome assembly factors 214 Schwer The RNA polymerase II CTD code in fission yeast 215 Shankar Novel interactions of the RAS oncogene 216 Sharma Calcium-mediated epigenetic regulation of alternative splicing in cardiomyocytes 217 Sharma Effect of MDS mutations on splicing factor function 218 Shults 17β-estradiol regulates the alternative splicing factor Nova1 in a brain-region specific manner in aged female rats 219 Singh Somatic spliceosomal factor mutations lead to alternative splicing patterns in myeloid neoplasms
220 Singh Rbfox2 is required for myoblast fusion during a late stage of myogenesis through regulated splicing of Mef2d and Rock2 221 Skrdlant Characterization of hematopoietic cells carrying Myelodysplasia-related spliceosomal SRSF2 mutations 222 Smietanski Structural studies of mRNA cap methylation 223 SOEMEDI CLARITY (Children’s Leadership Award for the Reliable Interpretation and appropriate Transmission of your genomic information) challenge—Case W1 224 Stubbs New roles for the RNA export protein, REF/Aly 225 Subbaram Integrin α3β1-dependent regulation of Cox2 mRNA splicing and stability in human breast cancer
226 Suchanek Binding of SRSF3 and hnRNP K to a bifunctional ESE/ESS regulates splicing of G6PD mRNA by nutritional status 227 TAGGART Large-scale study of branchpoint selection and its roles throughout the life cycle of the intron
228 Takeuchi RNA binding protein Sfpq is required for the expression of neuron-specific long pre-mRNAs essential for brain development 229 Tarn DDX3 modulates cell adhesion and motility and cancer cell metastasis via the Rac1-mediated signaling pathway 230 Tat Actively translating deadenylated mRNAs in Drosophila S2 cells 231 Thénoz Alternative splicing signatures discriminate ATL cells from untransformed CD4+ counterparts deriving from HTLV-1 infected individuals 232 Thénoz Tax promotes the expression of the alternative spliced isoform CD44v10 by slowing down the elongating RNA polymerase II 233 Tokmakov mRNA degradation in apoptotic Xenopus eggs
Page 9 of 12 234 Tretbar Single-molecule studies of the DEAD-box ATPase Prp5 during spliceosomal A complex formation
235 Tsai Computational analyses of alternative trans-splicing in Trypanosoma brucei 236 Tsai Identification of prevalent RNA recognition motif duplication in human genome 237 Uren Integrative analysis of RIP- and RNA-Seq elucidates expression changes and splicing events directly regulated by human Tra2 beta 238 Vagner U1 snRNP-dependent regulation of pre-mRNA cleavage/polyadenylation by the ddx5/ddx17 RNA helicases during tumor progression 239 Vaillancourt-Jean Unraveling the role of the MAPK pathway in alternative splicing regulation through CDK12 phosphorylation 240 Venables Investigating conserved functional regulated alternative splicing 241 Wang Treatment of type 1 myotonic dystrophy by engineering site-specific RNA endonucleases that target (CUG)n repeats 242 West 3′ end formation influences the phosphorylation of RNA polymerase II CTD on serine 2 243 Wilusz What exactly does a poly(A) tail do in vivo? Using RNA triple helices to provide insights into retrotransposition mechanisms 244 Wu A surprisingly large number of alternatively spliced micro-exons in the mammalian genome 245 Wu OLego—Fast and sensitive mapping of spliced mRNA-Seq reads using small seeds 246 Wu U1 snRNP and polyadenylation signals control mammalian promoter directionality and limit pervasive transcription 247 Xia Dynamic analysis of alternative polyadenylation from RNA-Seq (DaPars) reveals global shortening of 3’UTRs in human cancers 248 Xie Inhibition of NMD factors UPF1-3 by a dietary compound to shift the homeostatic levels of splicing factors in correcting aberrant splicing of a disease transcript 249 Yang Circular intronic long noncoding RNAs 250 Yang Exploring the complex post-transcriptional roles of the ESRPs in genome-wide regulatory programs of EMT 251 Yeo Cellular and molecular systems to investigate an RNA gain-of-function mechanism in C9ORF72- ALS pathogenesis 252 Ying Characterization of a large Rbfox protein complex 253 Youngblood CstF-64 regulates cell cycle progression and histone mRNA processing in mouse embryonic stem cells 254 Yu DASplice—A powerful RNA-seq differential alternative splicing analysis method 255 Zaghlool Efficient cellular fractionation improves RNA sequencing analysis of mature and nascent transcripts from human tissues 256 Zhang Role of PTB and hnRNP A1/A2 and their splicing targets in glioblastoma 257 Zheng Compensatory and differential functions of PTBP1 and PTBP2 orchestrate multiple transitions in splicing programs during neural development
Page 10 of 12 258 Zheng A tumor virus protein promotes RNA splicing by antagonizing the negative splicing activity of SRSF3 259 Zhou Genome-wide analysis of transcription elongation and regulation
Session 8 TRANSLATIONAL CONTROL / DECAY MECHANISMS FRIDAY 8/23/2013, 9:00 AM R. Parker / N. Conrad # lname Title Talk Length 51 Ricci Transcriptome-wide mapping of Staufen1 binding sites reveals an intimate link to Alu elements 12 and a positive role in translation 52 Li Genome-wide analysis of Staufen-associated mRNAs identifies secondary structures that confer 12 target specificity 53 Harigaya Global analysis of translational control by the RNA-dependent ATPase DHH1 12 54 Lou Role of non-degradative ubiquitin signaling in mRNA stability control 12 55 Hennig Structural basis of the translational regulation of msl2 mRNA by SXL and UNR during dosage 12 compensation in Drosophila 56 Lykke-Andersen Degradation of the majority of endogenous human nonsense mRNAs is initiated via SMG6- 12 mediated endonucleolytic cleavage 57 French Transcriptome analysis reveals thousands of targets of nonsense-mediated mRNA decay that 12 offer clues to the mechanism in human, fish, and fly 58 durand UPF1 phosphorylation serves as an mRNA decay amplifier during nonsense-mediated mRNA 12 decay 59 Hopkins A genome-wide RNAi screen reveals that mRNA decapping restricts bunyaviral replication by 12 limiting the pools of Dcp2-accessible targets for cap-snatching 60 Richard A SUMO-dependant interaction between Senataxin and the exosome, disrupted in the 12 neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage
Session 9 RNA PROCESSING IN DEVELOPMENT AND DISEASE FRIDAY 8/23/2013, 2:00 PM M. Ares / A. Krainer # lname Title Talk Length 61 Calarco A pair of RNA binding proteins regulate neuron-subtype specific alternative splicing in C. 12 elegans 62 Song Single cell RNA-seq reveals transcriptome complexity during neuronal differentiation 12 63 Shi Fip1 regulates mRNA alternative polyadenylation to promote embryonic stem cell self-renewal and 12 somatic reprogramming 64 Buckroyd Concerted alterations in non-productive alternative splicing of core spliceosome components and 12 splicing factors during smooth muscle cell phenotypic modulation 65 Wolniak Post transcriptional control of rapid development after release from dormancy in Marsilea 12
66 Bebee A knockout mouse model to define the roles of the epithelial splicing regulatory proteins in 12 development and epithelial cell function Page 11 of 12 67 Garcia Developmental arrest of Drosophila survival motor neuron (Smn) mutants accounts for 12 differences in expression of minor intron-containing genes 68 Kalsotra Loss of Mef2 expression reactivates the embryonic cardiac microRNA program in myotonic 12 dystrophy type 1 69 Chen Splicing factor mutations in leukemia 12 70 Coady Disregulation of TLS function in Amyotrophic Lateral Sclerosis (ALS) results in aberrant RNA 12 splicing and stability.
Session 10 miRNA BIOGENESIS AND FUNCTION / ncRNA PROCESSING SATURDAY 8/24/2013, 9:00 AM F. Gebauer / E. Lund # lname Title Talk Length 71 Proudfoot LncRNA gene transcription terminated by the microprocessor promotes high levels of miRNA 12 production 72 Zamudio Characterization of Argonaute-deficient mouse embryonic stem cells 12 73 Serebrov A single molecule view of Argonaute function 12 74 Li Defining a human protein interactome involved in microRNA biogenesis and regulation 12 75 Ramaiah An X-linked microRNA with the unique ability to globally promote translation 12 76 Yu Minotaur is critical for primary piRNA biogenesis 12 77 Barberan Co-option of the piRNA pathway for germline-specific alternative splicing of C. elegans 12 TOR 78 Passoni Splicing-mediated decay regulates expression of intronless genes in S. cerevisiae 12 79 Saldi TDP-1, the C. elegans ortholog of TDP-43, limits the accumulation of double stranded RNA 12
80 Brown Formation of triple-helical structures by the 3′-end sequences of MALAT1 and MENβ noncoding 12 RNAs
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