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Searchable Database of Spliceosome Proteins

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A B C Spliceosomal proteins. Genes are divided into categories according to their best known function. Official gene name, original gene name, and full official names are listed.. Yellow shading indicates well-known canonical splicing factors. 1 2 Official Name Original Name Full Official Name 3 4 CAP Binding Proteins 5 NCBP1 CBP80 Nuclear Cap Binding Protein Subunit 1, 80 kDa 6 NCBP2 CBP20 Nuclear Cap Binding Protein Subunit 2, 20 kDa 7 RNMT RG7MT1 RNA (guanine-7-) methyltransferase 8 9 U1 snRNP Components and Associated Proteins 10 ARGLU1 ARGLU1 Arginine And Glutamate Rich 1 11 DDX5 p68 DEAD-Box Helicase 5 12 DHX9 RHA DExH-Box Helicase 9 13 EWSR1 EWS EWS RNA Binding Protein 1 14 FUS hnRNP P2 FUS RNA Binding Protein 15 LUC7L pLUC7L LUC7 Like 16 LUC7L3 LUC7A LUC7-like 3 17 PRPF40A FBP-11 Pre-MRNA Processing Factor 40 Homolog A 18 PRPF4B PRP4 Kinase Pre-MRNA Processing Factor 4B 19 RBM25 fSAP49 RNA binding motif protein 25; promotes U1 binding to 5' splice site 20 SNRNP70 U170K Small Nuclear Ribonucleoprotein 70 kDa 21 SNRPA U1A Small Nuclear Ribonucleoprotein Polypeptide A 22 SNRPC U1C Small Nuclear Ribonucleoprotein Polypeptide C 23 TIA1 TIA1 TIA1 Cytotoxic Granule-Associated RNA Binding Protein 24 TIAL1 TIAR TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 25 26 SR Proteins 27 SRSF1 ASF, SF2 Serine/Arginine-rich Splicing Factor 1 28 SRSF11 p54, NET2 Serine/Arginine-rich Splicing Factor 11 29 SRSF2 SC35 Serine/Arginine-rich Splicing Factor 2 30 SRSF3 SRP20 Serine/Arginine-rich Splicing Factor 3 31 SRSF4 SRP75 Serine/Arginine-rich Splicing Factor 4 32 SRSF5 SRP40 Serine/Arginine-rich Splicing Factor 5 33 SRSF6 SRP55 Serine/Arginine-rich Splicing Factor 6 34 SRSF7 9G8 Serine/Arginine-rich Splicing Factor 7 35 SRSF9 SRp30c Serine/Arginine-rich Splicing Factor 9 A B C 36 TRA2A TRA-2 Alpha Transformer 2 alpha homolog (Drosophila) 37 TRA2B TRA-2 Beta Transformer 2 beta homolog (Drosophila) 38 39 3' Splice-site and Branchpoint Binding Proteins 40 PUF60 PUF60 Poly-U binding splicing factor 60KDa 41 SF1 BBP Splicing factor 1 42 U2AF1 U2AF35 U2 small nuclear RNA auxiliary factor 1 43 U2AF2 U2AF65 U2 small nuclear RNA auxiliary factor 2 44 45 U2 snRNP Components 46 DDX46 hPRP5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 47 HTATSF1 TAT-SF1 HIV-1 Tat specific factor 1 48 PHF5A SF3B14b PHD finger protein 5A 49 SF3A1 SAP114 Splicing Factor 3A, Subunit 1 50 SF3A2 SAP62 Splicing Factor 3A, Subunit 2 51 SF3A3 SAP61 Splicing Factor 3A, Subunit 3 52 SF3B1 SAP155 Splicing Factor 3B, Subunit 1 53 SF3B2 SAP145 Splicing Factor 3B, Subunit 2 54 SF3B3 SAP130 Splicing Factor 3B, Subunit 3 55 SF3B4 SAP49 Splicing Factor 3B, Subunit 4 56 SF3B5 SF3b10 Splicing Factor 3b Subunit 5 57 SF3B6 SF3B14a Splicing Factor 3b Subunit 6 58 SNRPA1 U2A' Small Nuclear Ribonucleoprotein Polypeptide A' 59 SNRPB2 U2B" Small Nuclear Ribonucleoprotein Polypeptide B2 60 U2SURP fSAPa U2 snRNP-associated SURP domain containing 61 62 U4, U5, U6 snRNPs Components 63 CD2BP2 U5-52 CD2 (cytoplasmic tail) binding protein 2 64 DDX23 U5-100 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 65 EFTUD2 U5-116 Elongation Factor Tu GTP Binding Domain Containing 2 66 PPIH PPIH Peptidylprolyl isomerase H (cyclophilin H) 67 PRPF3 hPRP3 Pre-mRNA processing factor 3 68 PRPF31 hPRP31 Pre-mRNA processing factor 31 69 PRPF4 hPRP4 Pre-mRNA processing factor 4 70 PRPF6 U5-102 Pre-mRNA processing factor 6 71 PRPF8 PRP8 Pre-mRNA prcessing factor 8 72 SART1 SNU66 SART1, U4/U6.U5 Tri-SnRNP-Associated Protein 1 A B C 73 SART3 U6 snRNP-binding proteinSquamous Cell Carcinoma Antigen Recognized By T Cells 3 74 SNRNP200 U2-200 Small Nuclear Ribonucleoprotein U5 Subunit 200 75 SNRNP40 U5-40 Small Nuclear Ribonucleoprotein U5 Subunit 40 76 SNU13 hSNU13 Small Nuclear Ribonucleoprotein 13 77 TXNL4A U5-15 Thioredoxin Like 4A 78 USP39 SAD1 Ubiquitin Specific Peptidase 39 79 80 PRP19 Complex Proteins 81 AQR Aquarius Aquarius Intron-Binding Spliceosomal Factor 82 CDC5L CDC5L Cell division cycle 5-like 83 CRNKL1 hCRN Crooked neck pre-mRNA splicing factor 1 84 PRPF19 hPRP19 Pre-mRNA processing factor 19 85 XAB2 SYF1 XPA Binding Protein 2 86 87 Sm Core Proteins 88 SNRPB SmB/B' Small Nuclear Ribonucleotide Polypeptides B and B1 89 SNRPD1 SmD1 Small Nuclear Ribonucleoprotein D1 Polypeptide 16 kDa 90 SNRPD2 SmD2 Small Nuclear Ribonucleoprotein D2 Polypeptide 16.5 kDa 91 SNRPD3 SmD3 Small Nuclear Ribonucleoprotein D3 Polypeptide 18 kDa 92 SNRPE SmE Small Nuclear Ribonucleoprotein Polypeptide E 93 SNRPF SmF Small Nuclear Ribonucleoprotein Polypeptide F 94 SNRPG SmG Small Nuclear Ribonucleoprotein Polypeptide G 95 LSM1 hLSm1 LSM1 Homolog, U6 snRNA and mRNA Degradation Associated 96 LSM2 hLSm2 LSM2 Homolog, U6 snRNA and mRNA Degradation Associated 97 LSM3 hLSm3 LSM3 Homolog, U6 snRNA and mRNA Degradation Associated 98 LSM4 hLSm4 LSM4 Homolog, U6 snRNA and mRNA Degradation Associated 99 LSM6 hLSm6 LSM6 Homolog, U6 snRNA and mRNA Degradation Associated 100 LSM7 hLsm7 LSM7 Homolog, U6 snRNA and mRNA Degradation Associated 101 SNRPN SNRPN Small Nuclear Ribonucleoprotein Polypeptide N 102 103 Catalytic Step II Factors 104 CDC40 hPRP17 Cell division cycle 40 105 DHX15 hPRP43 DEAH (Asp-Glu-Ala-His) box helicase 15 106 DHX38 hPRP16 DEAH (Asp-Glu-Ala-His) box polypeptide 38 107 DHX8 hPRP22 DEAH (Asp-Glu-Ala-His) box polypeptide 8 108 PRPF18 hPRP18 Pre-mRNA processing factor 18 109 SLU7 hSLU7 SLU7 Homolog, Splicing Factor A B C 110 111 Cyclophilin-liKe Spliceosome Proteins 112 PPIE Cyclophilin-33 Peptidylprolyl Isomerase Like 3 113 PPIL1 CYPL1 Peptidylprolyl Isomerase Like 1 114 PPIL2 Cyclophilin-60 Peptidylprolyl Isomerase Like 2 115 PPIL3 Cyclophilin J Peptidylprolyl Isomerase Like 3 116 117 Exon Junction Complex Proteins 118 ACIN1 Acinus Apoptotic chromatin condensation inducer 1 119 CWC22 fSAPb CWC22 spliceosome-associated protein 120 EIF4A3 eIF4A3 Eukaryotic translation initiation factor 4A3 121 MAGOH Magoh Mago-nashi homolog, proliferation-associated 122 PYM1 WIBG PYM Homolog 1, Exon Junction Complex Associated Factor 123 RBM8A Y14 RNA binding motif protein 8A 124 RNPS1 RNPS1 RNA binding protein S1, serine-rich domain 125 SRRM1 SRm160 Serine And Arginine Repetitive Matrix 1 126 127 HnRNP Proteins 128 HNRNPA1 hnRNP A1 Heterogeneous nuclear ribonucleoprotein A1 129 HNRNPA2B1 hnRNPA2B1 Heterogeneous nuclear ribonucleoprotein A2B1 130 HNRNPC hnRNP C Heterogeneous nuclear ribonucleoprotein C (C1/C2) 131 HNRNPD hnRNP D Heterogeneous nuclear ribonucleoprotein D 132 HNRNPDL hnRNPDL Heterogeneous Nuclear Ribonucleoprotein D Like 133 HNRNPF hnRNP F Heterogeneous nuclear ribonucleoprotein F 134 HNRNPH1 hnRNPH1 Heterogeneous nuclear ribonucleoprotein H1 (H) 135 HNRNPH2 hnRNPH2 Heterogeneous nuclear ribonucleoprotein H2 136 HNRNPK hnRNP K Heterogeneous nuclear ribonucleoprotein K 137 HNRNPL hnRNP L Heterogeneous nuclear ribonucleoprotein L 138 HNRNPM hnRNP M Heterogeneous nuclear ribonucleoprotein M 139 HNRNPR hnRNP R Heterogeneous nuclear ribonucleoprotein R 140 HNRNPU hnRNP U Heterogeneous nuclear ribonucleoprotein U (SAFA) 141 PTBP1 hnRNP I Polypyrimidine tract binding protein 1 142 RALY RALY RALY heterogeneous nuclear ribonucleoprotein 143 144 Non-snRNP Spliceosomal Proteins 145 BCAS2 SPF27 Breast carcinoma amplified sequence 2 146 BUB3 hBUB3 BUB3 mitotic checkpoint protein A B C 147 BUD13 fSAP71 BUD13 homolog (S. cerevisiae) 148 BUD31 BUD31 BUD31 homolog (S. cerevisiae) 149 CACTIN CACTIN Cactin, spliceosome C complex subunit 150 CDK12 CRKRS Cyclin-dependent kinase 12 151 CFAP20 fSAP23 Cilia and flagella associated protein 20 152 CIRBP CIRP Cold inducible RNA binding protein 153 CTNNBL1 NAP Catenin, beta like 1 154 DDX17 p72 DEAD-Box Helicase 17 155 DDX3X DDX3 DEAD-Box Helicase 3, X-Linked 156 DDX41 Abstract DEAD-Box Helicase 41 157 DHX16 hPRP2 DEAH-Box Helicase 16 158 DNAJC8 SPF31 DnaJ (Hsp40) homolog, subfamily C, member 8 159 ELAVL1 HUR ELAV like RNA binding protein 1 160 ENO1 MBP1 Enolase 1 161 ESS2 DGCR14 DiGeorge syndrome critical region gene 14 162 FUBP3 FBP3 Far upstream element (FUSE) binding protein 3 163 GTF2I GTFII-I General Transcription Factor IIi 164 IK PRP4 Kinase IK cytokine, down-regulator of HLA II 165 ILF2 nFAT-45 Interleukin enhancer binding factor 2 166 ILF3 nFAT-90 Interleukin enhancer binding factor 3 167 KHDRBS1 Sam68 KH RNA Binding Domain Containing, Signal Transduction Associated 1 168 MATR3 MATRIN3 Matrin 3 169 MFAP1 MFAP1 Microfibrillar-associated protein 1 170 MOV10 FSAP113 Mov10 RISC Complex RNA Helicase 171 NONO p54 Non-POU Domain Containing Octamer Binding 172 PAXBP1 fSAP105 PAX3 and PAX7 binding protein 1 173 PLRG1 PRP46 Pleiotropic regulator 1 174 PPM1G Pp2Cgamma Protein phosphatase, Mg2+/Mn2+ dependent, 1G 175 PRPF38A PRPF38A Pre-MRNA Processing Factor 38A 176 PTH2 TIP39 Parathyroid Hormone 2 177 RBM4 Lark Homolog RNA Binding Motif Protein 4 178 RBM15 OTT RNA binding motif protein 15 179 RBM17 SPF45 RNA binding motif protein 17 180 RBM22 fSAP47 RNA binding motif protein 22 181 RBM39 CAPER RNA binding motif protein 39 182 SERBP1 PAI1 RNA-Binding Protein SERPINE11 MRNA Binding Protein 1 183 SFPQ PSF Splicing Factor Proline And Glutamine Rich A B C 184 SMU1 fSAP57 Smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) 185 SPHKAP SKIP SPHK1 interactor, AKAP domain containing 186 SRRM2 SRm300 Serine/arginine repetitive matrix 2 187 SYF2 fSAP29 SYF2 pre-mRNA-splicing factor 188 TCERG1 CA150 Transcription elongation regulator 1 189 TRIR fSAP18 Telomerase RNA Component Interacting Rnase 190 WDR77 Methylosome Protein 50 WD Repeat Domain 77 191 WBP11 WBP11 WW domain binding protein 11 192 WTAP WTAP
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  • Transcriptome Sequencing and Genome-Wide Association Analyses Reveal Lysosomal Function and Actin Cytoskeleton Remodeling in Schizophrenia and Bipolar Disorder

    Transcriptome Sequencing and Genome-Wide Association Analyses Reveal Lysosomal Function and Actin Cytoskeleton Remodeling in Schizophrenia and Bipolar Disorder

    Molecular Psychiatry (2015) 20, 563–572 © 2015 Macmillan Publishers Limited All rights reserved 1359-4184/15 www.nature.com/mp ORIGINAL ARTICLE Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder Z Zhao1,6,JXu2,6, J Chen3,6, S Kim4, M Reimers3, S-A Bacanu3,HYu1, C Liu5, J Sun1, Q Wang1, P Jia1,FXu2, Y Zhang2, KS Kendler3, Z Peng2 and X Chen3 Schizophrenia (SCZ) and bipolar disorder (BPD) are severe mental disorders with high heritability. Clinicians have long noticed the similarities of clinic symptoms between these disorders. In recent years, accumulating evidence indicates some shared genetic liabilities. However, what is shared remains elusive. In this study, we conducted whole transcriptome analysis of post-mortem brain tissues (cingulate cortex) from SCZ, BPD and control subjects, and identified differentially expressed genes in these disorders. We found 105 and 153 genes differentially expressed in SCZ and BPD, respectively. By comparing the t-test scores, we found that many of the genes differentially expressed in SCZ and BPD are concordant in their expression level (q ⩽ 0.01, 53 genes; q ⩽ 0.05, 213 genes; q ⩽ 0.1, 885 genes). Using genome-wide association data from the Psychiatric Genomics Consortium, we found that these differentially and concordantly expressed genes were enriched in association signals for both SCZ (Po10 − 7) and BPD (P = 0.029). To our knowledge, this is the first time that a substantially large number of genes show concordant expression and association for both SCZ and BPD. Pathway analyses of these genes indicated that they are involved in the lysosome, Fc gamma receptor-mediated phagocytosis, regulation of actin cytoskeleton pathways, along with several cancer pathways.
  • DEAD-Box RNA Helicases in Cell Cycle Control and Clinical Therapy

    DEAD-Box RNA Helicases in Cell Cycle Control and Clinical Therapy

    cells Review DEAD-Box RNA Helicases in Cell Cycle Control and Clinical Therapy Lu Zhang 1,2 and Xiaogang Li 2,3,* 1 Department of Nephrology, Renmin Hospital of Wuhan University, Wuhan 430060, China; [email protected] 2 Department of Internal Medicine, Mayo Clinic, 200 1st Street, SW, Rochester, MN 55905, USA 3 Department of Biochemistry and Molecular Biology, Mayo Clinic, 200 1st Street, SW, Rochester, MN 55905, USA * Correspondence: [email protected]; Tel.: +1-507-266-0110 Abstract: Cell cycle is regulated through numerous signaling pathways that determine whether cells will proliferate, remain quiescent, arrest, or undergo apoptosis. Abnormal cell cycle regula- tion has been linked to many diseases. Thus, there is an urgent need to understand the diverse molecular mechanisms of how the cell cycle is controlled. RNA helicases constitute a large family of proteins with functions in all aspects of RNA metabolism, including unwinding or annealing of RNA molecules to regulate pre-mRNA, rRNA and miRNA processing, clamping protein complexes on RNA, or remodeling ribonucleoprotein complexes, to regulate gene expression. RNA helicases also regulate the activity of specific proteins through direct interaction. Abnormal expression of RNA helicases has been associated with different diseases, including cancer, neurological disorders, aging, and autosomal dominant polycystic kidney disease (ADPKD) via regulation of a diverse range of cellular processes such as cell proliferation, cell cycle arrest, and apoptosis. Recent studies showed that RNA helicases participate in the regulation of the cell cycle progression at each cell cycle phase, including G1-S transition, S phase, G2-M transition, mitosis, and cytokinesis.