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CELL BIOLOGY of the NEURON Polarity, Plasticity and Regeneration

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CELL BIOLOGY of the NEURON Polarity, Plasticity and Regeneration Abstracts of papers presented at the EMBO Workshop CELL BIOLOGY OF THE NEURON Polarity, Plasticity and Regeneration 7‐10 May 2011, Heraklion, Greece Abstracts of papers presented at the EMBO Workshop CELL BIOLOGY OF THE NEURON Polarity, Plasticity and Regeneration 7‐10 May 2011, Heraklion, Greece Organizers: Frank Bradke, Max Planck Institute of Neurobiology, Germany Casper Hoogenraad, Utrecht University, The Netherlands Nektarios Tavernarakis, Institute of Molecular Biology and Biotechnology, Greece The meeting was funded in part by EMBO (European Molecular Biology Organization) CELL BIOLOGY OF THE NEURON: POLARITY, PLASTICITY AND REGENERATION Saturday, May 7 – Tuesday, May 10, 2011 .. at a glance Saturday 14.15 1 Synaptogenesis Saturday 16.30 2 Neuronal Plasticity – Receptor Dynamics Saturday 20.00 Keynote Lecture 1 Saturday 21.00 Poster Session I – Red Session Sunday 09.00 3 Neuronal Regeneration Sunday 11.15 4 Local mRNA translation Sunday 14.15 5 Neuronal Plasticity – Cytoskeleton Sunday 16.00 Poster Session II – Green Session Sunday 19.30 Keynote Lecture 2 Monday 09.00 6 Neuronal Polarity Monday 11.15 7 Axon Growth and Regeneration Monday 14.00 Poster Session III – Blue Session Monday 16.15 Keynote Lecture 3 Monday 17.45 8 Hot‐topic Session Tuesday 09.00 9 Neuronal Trafficking Tuesday 11.15 10 Synaptogenesis Poster Sessions are located in the “Game Room” These abstracts should not be cited in bibliographies. Material contained herein should be treated as personal communication and should be cited as such only with consent of the author. Please note that recording of oral sessions by audio, video or still photography is strictly prohibited except with the advance permission of the author(s) and the organizers. TABLE OF CONTENTS PROGRAM ...................................................................................................................... 19 AUTHOR INDEX ............................................................................................................... 25 ORAL PRESENTATIONS ‐ ABSTRACTS............................................................................... 33 POSTER PRESENTATIONS ‐ ABSTRACTS........................................................................... 83 PARTICIPANT LIST ........................................................................................................... 209 USEFUL INFORMATION ................................................................................................... 221 ORAL PRESENTATIONS ABSTRACTS Molecular Mechanisms of Synapse Stabilization and Disassembly Gaeme W. Davis................................................................................................................ 33 Long Term Dynamics of Inhibitory Synapses Ann Marie Craig, Frederick Dobie ..................................................................................... 34 Dynamic Regulation of Synaptic Adhesion Complexes by Alternative Splicing P. Scheiffele, T.i Iijima, K.n Wu, H.d Witte......................................................................... 35 Role of Leucine‐Rich Repeat Containing Proteins in Excitatory Synapse Development J. De Wit, M.w O'Sullivan, J.f Savas, E.y Sylwestrak, D. Comoletti, J. Yates, A. Ghosh....... 36 A Nanoscale View into the Dynamic of AMPA Receptor Organization in Synapses D. Choquet ........................................................................................................................ 37 Regulation of Neuronal Function and Dysfunction by Protein SUMOylation J. Henley ............................................................................................................................ 38 Intracellular Machinery and Signaling for AMPA Receptor Trafficking at Synapses J. A. Esteban ...................................................................................................................... 39 Non hyperpolarizing GABAB Receptors Regulate Neuronal Migration, and Axon/Dendrite Growth and Specification by cAMP Pathway G.e Bony, A. Contestabile, L. Cancedda............................................................................. 40 Endocytic mechanisms at synapses P. De Camilli ...................................................................................................................... 41 Control of Motor Neuron Generation and Regeneration in Zebrafish C. Becker, A. Norris, V. Kuscha, R.e Patani, M. Reimer, A. Scott, Z. Zhong, T. Dias, S. Chandran, T. Becker ...................................................................................................... 42 Nogo‐ A is a Negative Regulator of Neurite Growth in the Developing and Adult Nervous System M. Schwab......................................................................................................................... 43 Defining the Genetic Pprogram of Axon Regeneration in the CNS Z. He .................................................................................................................................. 44 Regeneration of the Adult Zebrafish Brain after Traumatic Lesion: Neurogenic Radial Glia‐Type Progenitor Cells Make New Neurons M. Brand ........................................................................................................................... 45 RNA‐Based Control of Visual System Wiring C. Holt................................................................................................................................ 46 Identification of Localized mRNAs in Hippocampal Neurons E.n M. Schuman ................................................................................................................ 47 vii CYFIP1, a Neuronal eIF4E‐BP, Links Local Translational Regulation to Spine Remodeling: Insights into Mental Retardation and Autism C. Bagni, S, De Rubeis........................................................................................................ 48 CNP/cGMP Signaling Regulates Axon Branching and Growth by Modulating Microtubule Dynamics L. Ma, C. Xia, Z. Zhao, Z. Wang.......................................................................................... 49 Regulating Synaptic Strength Across the Cleft by N‐cadherins N. Vitureira, M. Letellier, I. White, Y. Goda ....................................................................... 50 Presynaptic Tenacity: Insights from Live Imaging Experiments Z. Noam ............................................................................................................................ 51 Class‐specific Dendrite Morphology Control by the Actin Bundling Protein Fascin J. Negele, C. Delandre, Y. Zhang, F. Förstner, A. Moore, G. Tavosanis ............................. 52 EB3 Stably links Microtubules to Ankyrin G in the Axon Initial Segment C. Leterrier, H. Vacher, M.‐P. Fache, S. A. d'Ortoli, F. Castets, A. Autillo‐Touati , B. Dargent ........................................................................................................................ 53 Neurogenesis from Glial Cells – Novel Sources for New Neurons in the Adult Brain M. Götz ............................................................................................................................. 54 Establishment of Neuronal Polarity C. G. Dotti.......................................................................................................................... 55 Molecular Mechanisms Underlying Neuronal Polarization in vivo F. Polleux........................................................................................................................... 56 Neurotrophins Regulate Neuronal Polarity Acting Through Ca2+ and CaMKK K. Kaibuchi......................................................................................................................... 57 ADF/Cofilin Directs Neuritogenesis in the Developing Mammalian Brain K. Flynn, D. Neukirchen, S. Jacob, S. Tahirovic, B. Garvalov,R. Wedlich‐Söldner, J. V. Small, W. Witke, F. Bradke ....................................................................................... 58 Lpd Depletion Reveals a Novel SRF‐Dependent Function that Specifies Radial versus Tangential Migration of Bipolar Pyramidal Neurons E. M. Pinheiro, Z. Xie, A. L. Norovich, M. Vidaki, L.‐H. Tsai,F. B. Gertler .......................... 59 Enhancing the Regenerative Ability of Axons J. Fawcett .......................................................................................................................... 60 Signaling Axonal Regeneration in the CNS M. T Filbin ......................................................................................................................... 61 The Oriented Emergence of Axons from Retinal Ganglion Cells is Directed by Laminin Contact in vivo O. Randlett, L. Poggi, F. R Zolessi, W. A Harris ................................................................. 62 Dendrite Morphogenesis and Functional Implications Y.‐N. Jan ............................................................................................................................ 63 The role of Diverse Surface receptor Complexes in Controlling Axonal Branching D. Schmucker .................................................................................................................... 64 Controlling Axonal Polarization using Micropatterns M. Bisbal, S. Roth, J. Brocard, G. Bugnicourt, Y. Saoudi, A. Andrieux, S. Gory‐Fauré, C. Villard ............................................................................................................................... 65 viii Characterization of Voltage and Temperature Dependent
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