DOCSLIB.ORG

Donation: the Lifeblood of the NHS

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text

Load more

News from the Medical Research Council Autumn 2018 network Leading science for better health Bl d donation: the lifeblood of the NHS Opinion: How secure data sharing can help us treat dementia Network can also be downloaded as a PDF at: mrc.ukri.org/network CONTENTS News COMMENT FROM Happy birthday to the NHS! 4 Health data: first UK snapshot review 5 Fiona Watt EXECUTIVE CHAIR People As the UK Research and Innovation Royal recognition for Nobel Prize-winner 9 Champion for Talent and Skills, I'm passionate about supporting researchers at the most pivotal points of their careers. It seems clear that we should be investing in Funding the best people, regardless of career stage and geography. £900m for future leaders 15 To help build expertise and opportunities for future careers, we're adding more activities to the list of those eligible to researchers employed on MRC grants, to cover activities that do not directly relate to their Latest discoveries specific research project. Potential therapy identified for common Supporting the career development of research staff is cause of dementia 16 equally important as supporting our researchers. That's why we've introduced a new 'research co-investigator' status for Eye drops with turmeric extract could research staff on MRC grants, to provide recognition for treat common eye disease 17 their intellectual research contributions and to help career development (see page 3). Sharing data and recognising individual research contributions are vital, especially for early-career Features researchers. I'm pleased to see the Dementias Platform UK leading the way with their data portal – a secure platform Blood donation: the lifeblood of the NHS 6 for sharing and analysing dementia research data. They are adopting a system to 'badge' the contribution of everyone in MRC Festival: Bringing research to life 12 the team behind publications that involve use of their portal (see page 22). Working life: Dr Oluwafemi Akande 18 By nurturing our researchers and research staff we can Going further to make all clinical trials public 20 continue to support high-quality research for better health. Opinion: How secure data sharing can help Professor Fiona Watt us treat dementia 22 MRC Executive Chair NEWS New grant application status recognises research staff contributions network To support development and career magazine going digital progression, the MRC has introduced a new status of 'researcher After 15 years, this issue of Network co-investigator' to recognise the magazine is our last printed issue. But contributions of research staff on you can still find all our content online on grant applications. our website and blog. Applicants ineligible to be a principal investigator Since spring 2003 we've published 64 issues. Times have or co-investigator have historically had little changed, and our online subscriber numbers have grown formal recognition of their contributions to the to the extent that we feel going digital is the way forward. grant application and subsequent funded research. This has created a barrier to career Digital subscription progression for affected research staff, such as postdocs, technicians and clinical fellows. You can sign up to be notified when we publish new content on our website, blog or podcast. By managing By introducing the researcher co-investigator your subscriptions, through the following link, you can status, we hope to provide research staff with opt in and out at any time: recognition for their research contributions, mrc.io/mrcsubscribe to assist with their career progression. In addition to receiving recognition, those Back issues listed as a researcher co-investigator should be supported in their training and development Keen to read a print copy of an old issue? We are very throughout the grant, serving as a step towards happy to send past issues to you – get in touch at their desired career. [email protected]. For further information visit: mrc.io/rcoi Feedback As always, we love receiving your feedback. If you have any questions, comments or ideas please share them with us at: [email protected] Our website: mrc.ukri.org • Our blog: mrc.ukri.org/blog MRCNetwork | 3 NEWS New scheme for overseas researchers to come to the UK YEARS OF THE NHS 1948-2018 A new scheme allows researchers, scientists and academics from outside the European Economic Area to come to the UK for collaboration, training and work experience for up to two years. The 'UK Research and Innovation (UKRI) Science, Research and Academia' scheme, added to the Tier 5 (Temporary Worker – Government Authorised Exchange) visa route in July, has been introduced to increase efficiency and better suit the needs of researchers in Happy birthday to the NHS! the UK. Operated by UKRI it enables approved research On 5 July, the NHS celebrated a historic organisations to directly sponsor a broad range of milestone – its 70th birthday. Since its researchers – including specialist technicians – to work and train in the UK. The scheme complements the creation in 1948, the NHS has delivered a free Sponsored Researchers Tier 5 scheme that applies to healthcare service based on clinical need. UK universities, and which has been updated in line with the new scheme. UKRI will monitor the 12 approved Professor Fiona Watt, Executive Chair of the MRC, said: sponsor organisations. "MRC-funded research underpins many of the world-class treatments and methods of diagnosis used within the UKRI Chief Executive Professor Sir Mark Walport said: NHS today. "Research and innovation is inherently international, as are the unprecedented 21st century challenges we "Our close relationship with the NHS has given, and must address. continues to give, MRC-funded researchers the data, resources and inspiration they need to carry out "Global collaboration through the movement of life-changing research that makes a real difference to talented people plays an essential role in meeting these clinical practice." challenges and this new scheme will provide further support for international researchers to work and train To celebrate, we've launched an NHS 70 timeline showing in the UK." a selection of MRC research that has improved NHS treatment and services: from setting up a national network Read more: mrc.io/ukri-scheme of blood banks at the beginning of the World War II, to treating a rare liver disease in 2016. Direct specific questions to: [email protected] Explore our NHS 70 timeline: mrc.io/nhs-timeline Turn to page 6 to read about blood donation's beginnings. 4 | MRCNetwork For more news from across the MRC community, visit: mrc.ukri.org/news Health data: first UK snapshot review Health data research is a complex and flourishing area in the UK, as highlighted in a new MRC report. The Mapping the Landscape of UK Health Data The report acts as an important benchmark to help Research and Innovation report details key activities inform funder strategy, prevent duplication and and major investments made by UK public funders, encourage collaboration in the informatics sector, government, charities and universities. both within the field and for external stakeholders. Commissioned in 2017, the report is a snapshot of Dr Rob Buckle, Chief Science Officer at the MRC, said: activity in a fast-moving sector. It provides a unique "This report highlights what a diverse and exciting window into major investments made by 26 research area health data research is. This sector is thriving and, organisations, and informed the establishment of the in addition to its importance for promoting health and new MRC-funded national institute – Health Data wellbeing, has huge potential to help deliver the Research UK (HDR UK). HDR UK's mission is to make UK Industrial Strategy, making the UK a global leader game-changing improvements in the health of patients among the industries of the future." and populations through data science research and innovation. Read more at: mrc.io/hdruk-snapshot UK and India joining forces for global health Seven multidisciplinary research partnerships between the UK and India will lead projects to address the health needs of women and children in disadvantaged populations globally. Researchers in Ethiopia, Uganda, The Gambia, Zambia and Nepal will work with the seven partnerships to ensure that the results meet each country’s needs. The teams will receive a total of £10m under the Global Research Programme on Health initiative. Alex Harris, International Programme Manager at the MRC, said: "Every year, worldwide, 2.7 million babies die during the first 28 days of life and 99% of all maternal deaths occur in developing countries. Creating environments for healthy pregnancies and infant development is a major priority for global health research. This exciting initiative will see the UK and India join forces to tackle this key global health challenge." The MRC and the Economic and Social Research Council (ESRC), both part of UKRI, are delivering the programme in collaboration with the Department for International Development and India's Department of Biotechnology, under the Newton-Bhabha Fund. Read more about the projects: mrc.io/uk-india MRCNetwork | 5 FEATURE Bl d donation: the lifeblood of the NHS As the NHS turns 70, Petra Kiviniemi delves into the MRC archive to reveal a history of blood donation closely intertwined with the birth of the NHS. Every two seconds, someone needs blood. Blood donations help millions of people, and many would not be alive today if it wasn't for the generosity of donors and care by our NHS. But the experience of being a volunteer blood donor was a very different picture back in the 1920s. Back then, nearly a century ago – and more than 20 years before the birth of the NHS – donations needed to be directly transferred from one person to another.
Recommended publications
  • Present Post: Previous Positions Held: Honors/Awards Membership In

    Present Post: Previous Positions Held: Honors/Awards Membership In

    CURRICULUM VITAE Name: Vassilis Pachnis, M.D., Ph.D., FMedSci Date of Birth: 24 January 1953 Place of Birth: Athens, Greece Contact details: National Institute for Medical Research Institute of Molecular Biology and Biotechnology The Ridgeway, Mill Hill, Foundation for Research and Technology‐Hellas London NW7 1AA, UK. N. Plastira 100, GR‐70013, Heraklion, Greece tel. (+44) 02088162113 Tel. (+30) 2810391100 email: [email protected] Email: [email protected] Education: July 1980 University of Athens Medical School (Athens, Greece) M.D. magna cum laude June 1986 University of Pennsylvania, Philadelphia, PA (USA) Degree: Ph.D., Genetics Supervisor: Prof. Shirley Tilghman Nov 1986 – Mar 1988 Howard Hughes Medical Institute Center for Neurobiology and Behavior Columbia University, New York, NY (USA) Postdoctoral Fellow in Prof. Richard Axel's laboratory Apr 1988 – May 1991 Department of Genetics and Development Columbia University, New York, NY (USA) Postdoctoral fellow in Dr. Frank Costantini's laboratory Present Post: ‐ Head of Division of Molecular Neurobiology, National Institute for Medical Research, Medical Research Council (London, UK) ‐ Director of the Institute of Molecular Biology and Biotechnology of the Foundation for Research and Technology‐Hellas (Heraklion, Greece) Previous positions held: May 1991 – Feb 1997 Senior Scientific Staff, Group Leader, MRC National Institute for Medical Research, London (5/91‐2/97) Feb 1997 – Aug 2000 Tenured Senior Scientist, MRC National Institute for Medical Research, London Honors/Awards ‐ Scholarship from the National Scholarship Foundation of Greece for Academic excellence in Medical School ‐ Special Fellowship Award from the Leukemia Society of America (Jul 1989‐May 1991) ‐ Janssen Award for Life Time Achievement in Gastroenterology (2002) Membership in Academies ‐ Elected Fellow of the Academy of Medical Sciences, UK (2000).
  • Linking Neurons to Immunity: Lessons from Hydra COMMENTARY Yuuki Obataa and Vassilis Pachnisa,1

    Linking Neurons to Immunity: Lessons from Hydra COMMENTARY Yuuki Obataa and Vassilis Pachnisa,1

    COMMENTARY Linking neurons to immunity: Lessons from Hydra COMMENTARY Yuuki Obataa and Vassilis Pachnisa,1 According to the Greek mythology (1), Heracles’ sec- Hydra offers unique advantages to neuroscience re- ond labor was the destruction of the Lernaean Hydra, search as well. Its nervous system is an anatomically a fearsome fire-breathing monster with a dog-like simple network of sensory and ganglion neurons body and nine snake heads. Many had tried to slay that control a range of behaviors, including sponta- the Lernaean Hydra but in vain: Any head that was neous body contractions (5, 6). Remarkably, the an- cut off regrew and multiplied. It is remarkable how atomical organization and functional output of consistent the narrative of this myth is with our recent Hydra’s nervous system are reminiscent of the intrin- understanding of tissue and organ regeneration. Her- sic neural networks of the gastrointestinal tract in acles was successful not only because of his divine vertebrates, known as the enteric nervous system origin (he was the son of Zeus after all) and the help (ENS). The ENS is an assembly of nerve cells within of Athena, but particularly because of the assistance the gut wall, which are organized into the ganglia he received from his nephew Iolaus, who was assigned of the myenteric and submucosal plexus (7) and regu- the job of cauterizing the exposed stumps of the Hy- late most intestinal functions, including coordination of dra’s severed heads. Of course, we now understand smooth muscle contractions, the basis of intestinal why Iolaus’ contribution was so critical: His flame con- peristalsis (8).
  • EMBC Annual Report 2007

    EMBC Annual Report 2007

    EMBO | EMBC annual report 2007 EUROPEAN MOLECULAR BIOLOGY ORGANIZATION | EUROPEAN MOLECULAR BIOLOGY CONFERENCE EMBO | EMBC table of contents introduction preface by Hermann Bujard, EMBO 4 preface by Tim Hunt and Christiane Nüsslein-Volhard, EMBO Council 6 preface by Marja Makarow and Isabella Beretta, EMBC 7 past & present timeline 10 brief history 11 EMBO | EMBC | EMBL aims 12 EMBO actions 2007 15 EMBC actions 2007 17 EMBO & EMBC programmes and activities fellowship programme 20 courses & workshops programme 21 young investigator programme 22 installation grants 23 science & society programme 24 electronic information programme 25 EMBO activities The EMBO Journal 28 EMBO reports 29 Molecular Systems Biology 30 journal subject categories 31 national science reviews 32 women in science 33 gold medal 34 award for communication in the life sciences 35 plenary lectures 36 communications 37 European Life Sciences Forum (ELSF) 38 ➔ 2 table of contents appendix EMBC delegates and advisers 42 EMBC scale of contributions 49 EMBO council members 2007 50 EMBO committee members & auditors 2007 51 EMBO council members 2008 52 EMBO committee members & auditors 2008 53 EMBO members elected in 2007 54 advisory editorial boards & senior editors 2007 64 long-term fellowship awards 2007 66 long-term fellowships: statistics 82 long-term fellowships 2007: geographical distribution 84 short-term fellowship awards 2007 86 short-term fellowships: statistics 104 short-term fellowships 2007: geographical distribution 106 young investigators 2007 108 installation
  • UKI NETS 11Th National Conference 25 November 2013 the Royal College of Physicians London, UK

    UKI NETS 11Th National Conference 25 November 2013 the Royal College of Physicians London, UK

    UKI NETS 11th National Conference 25 November 2013 The Royal College of Physicians London, UK Abstract Marking Panel Alan Anthoney (Leeds, UK) Simon Aylwin (London, UK) Dr Tu Vinh Luong (London, UK) Prakesh Manoharan (Manchester, UK) Nick Reed (Glasgow, UK) UKI NETS would like to thank their sponsors for their kind generosity: Educational Sponsors: Meeting Sponsor: UKI NETS Euro House 22 Apex Court Tel: +44-(0)1454 642277 Woodlands Fax: +44-(0)1454 642222 Bradley Stoke Email: [email protected] Bristol, BS32 4JT, UK Website: www.ukinets.org 2 Contents Pages Programme 4 – 6 Speaker Biographies 7 - 10 Abstracts 12 – 67 3 Programme CPD UKI NETS 11TH NATIONAL CONFERENCE has been approved by the Federation of the Royal Colleges of Physicians of the United Kingdom for 6 category 1 (external) CPD credits. 08:30 Registration, Coffee and Poster viewing 09:25 Welcome and opening remarks Nick Reed (Glasgow, UK) 09:30 – 11:00 Session 1 – Pancreatic NETS –who when and how to intervene? Chair: Graeme Poston 09:30 Imaging assessment of the incidental pancreatic mass Dylan Lewis (London, UK) 09:50 Management of pancreatic primary in presence of metastatic disease Massimo Falconi (Torrette-Ancona, Italy) 10:10 Localisation of insulinoma Karim Meeran (London, UK) 10:30 Surgical approach to the pancreas and parathyroid in patients with MEN1/VHL Barney Harrison (Sheffield, UK) 10:50 Open Floor Q&A 11:00 Coffee, poster viewing and exhibition 11:30 - 12:15 Session 2a – Management dilemmas - Debate – Chemotherapy is first line treatment for pancreatic metastatic
  • EMBO Facts & Figures

    EMBO Facts & Figures

    excellence in life sciences Reykjavik Helsinki Oslo Stockholm Tallinn EMBO facts & figures & EMBO facts Copenhagen Dublin Amsterdam Berlin Warsaw London Brussels Prague Luxembourg Paris Vienna Bratislava Budapest Bern Ljubljana Zagreb Rome Madrid Ankara Lisbon Athens Jerusalem EMBO facts & figures HIGHLIGHTS CONTACT EMBO & EMBC EMBO Long-Term Fellowships Five Advanced Fellows are selected (page ). Long-Term and Short-Term Fellowships are awarded. The Fellows’ EMBO Young Investigators Meeting is held in Heidelberg in June . EMBO Installation Grants New EMBO Members & EMBO elects new members (page ), selects Young EMBO Women in Science Young Investigators Investigators (page ) and eight Installation Grantees Gerlind Wallon EMBO Scientific Publications (page ). Programme Manager Bernd Pulverer S Maria Leptin Deputy Director Head A EMBO Science Policy Issues report on quotas in academia to assure gender balance. R EMBO Director + + A Conducts workshops on emerging biotechnologies and on H T cognitive genomics. Gives invited talks at US National Academy E IC of Sciences, International Summit on Human Genome Editing, I H 5 D MAN 201 O N Washington, DC.; World Congress on Research Integrity, Rio de A M Janeiro; International Scienti c Advisory Board for the Centre for Eilish Craddock IT 2 015 Mammalian Synthetic Biology, Edinburgh. Personal Assistant to EMBO Fellowships EMBO Scientific Publications EMBO Gold Medal Sarah Teichmann and Ido Amit receive the EMBO Gold the EMBO Director David del Álamo Thomas Lemberger Medal (page ). + Programme Manager Deputy Head EMBO Global Activities India and Singapore sign agreements to become EMBC Associate + + Member States. EMBO Courses & Workshops More than , participants from countries attend 6th scienti c events (page ); participants attend EMBO Laboratory Management Courses (page ); rst online course EMBO Courses & Workshops recorded in collaboration with iBiology.
  • Trustees' Annual Report and Financial Statements 31 March 2016

    Trustees' Annual Report and Financial Statements 31 March 2016

    THE FRANCIS CRICK INSTITUTE LIMITED A COMPANY LIMITED BY SHARES TRUSTEES’ ANNUAL REPORT AND FINANCIAL STATEMENTS 31 MARCH 2016 Charity registration number: 1140062 Company registration number: 6885462 The Francis Crick Institute Accounts 2016 CONTENTS INSIDE THIS REPORT Trustees’ report (incorporating the Strategic report and Directors’ report) 1 Independent auditor’s report 12 Consolidated statement of financial activities 13 Balance sheets 14 Cash flow statements 15 Notes to the financial statements 16 1 TRUSTEES’ REPORT (INCORPORATING THE STRATEGIC REPORT AND DIRECTORS’ REPORT) The trustees present their annual directors’ report together with the consolidated financial statements for the charity and its subsidiary (together, ‘the Group’) for the year ended 31 March 2016, which are prepared to meet the requirements for a directors’ report and financial statements for Companies Act purposes. The financial statements comply with the Charities Act 2011, the Companies Act 2006, and the Statement of Recommended Practice applicable to charities preparing their accounts in accordance with the Financial Reporting Standard applicable in the UK (FRS102) effective 1 January 2015 (Charity SORP). The trustees’ report includes the additional content required of larger charities. REFERENCE AND ADMINISTRATIVE DETAILS The Francis Crick Institute Limited (‘the charity’, ‘the Institute’ or ‘the Crick) is registered with the Charity Commission, charity number 1140062. The charity has operated and continues to operate under the name of the Francis Crick
  • Paterson Institute for Cancer Research Scientific Report 2008 Contents

    Paterson Institute for Cancer Research Scientific Report 2008 Contents

    paterson institute for cancer research scientific report 2008 cover images: Main image supplied by Karim Labib and Alberto sanchez-Diaz (cell cycle Group). Budding yeast cells lacking the inn1 protein are unable to complete cytokinesis. these cells express a fusion of a green fluorescent protein to a marker of the plasma membrane, and have red fluorescent proteins attached to components of the spindle poles and actomyosin ring (sanchez-Diaz et al., nature cell Biology 2008; 10: 395). Additional images: front cover image supplied by Helen rushton, simon Woodcock and Angeliki Malliri (cell signalling Group). the image is of a mitotic spindle in fixed MDcK (Madin-Darby canine kidney) epithelial cells, which have been stained with an anti-beta tubulin antibody (green), DApi (blue) and an anti-centromere antibody (crest, red) which recognises the kinetochores of the chromosomes. the image was taken on the spinning disk confocal microscope using a 150 x lens. rear cover image supplied by Andrei ivanov and tim illidge (targeted therapy Group). Visualisation of tubulin (green) and quadripolar mitosis (DnA stained with DApi), Burkitt’s lymphoma namalwa cell after 10 Gy irradiation. issn 1740-4525 copyright 2008 © cancer research UK Paterson Institute for Cancer Research Scientific Report 2008 Contents 4 Director’s Introduction Researchers’ pages – Paterson Institute for Cancer Research 8 Crispin Miller Applied Computational Biology and Bioinformatics 10 Geoff Margison Carcinogenesis 12 Karim Labib Cell Cycle 14 Iain Hagan Cell Division 16 Nic Jones
  • PROGRAMME & Book of Abstracts

    PROGRAMME & Book of Abstracts

    PROGRAMME & book of abstracts “. MOVING FORWARD TOGETHER” www.EDBC2019Alicante.com ORGANISED BY CONTENTS SPONSORS & COLLABORATORS ORGANIZATION .......................................................................... 4 GENERAL INFORMATION ......................................................... 5 INSTRUCTIONS FOR SPEAKERS AND AUTHORS ................ 8 CONGRESS TIMETABLE ............................................................ 9 SCIENTIFIC PROGRAMME WEDNESDAY 23 .................................................................... 12 THURSDAY 24 ........................................................................ 13 FRIDAY 25 ............................................................................... 16 SATURDAY 26 ........................................................................ 19 POSTER SESSIONS ................................................................... 21 EXHIBITORS AND SPONSORS ................................................ 48 ABSTRACTS ................................................................................ 51 AUTHORS’ INDEX ...................................................................... 263 4 EDBC2019 EDBC2019 5 ORGANIZATION GENERAL INFORMATION ORGANIZING COMMITTEE INVITED SPEAKERS VENUE Ángela Nieto. Alicante Enrique Amaya. Manchester Auditorio de la Diputación de Alicante - ADDA Víctor Borrell. Alicante Detlev Arendt. Heidelberg Paseo Campoamor, s/n Sergio Casas-Tintó. Madrid Laure Bally Cuif. Paris 03010 Alicante, Spain Pilar Cubas. Madrid Fernando Casares. Sevilla www.addaalicante.es
  • Report 2003-2008 Report 2003-2008 Editors

    Report 2003-2008 Report 2003-2008 Editors

    Report 2003-2008 Report 2003-2008 Editors: The Board of Directors Interdisciplinary Center for Neurosciences (IZN) University of Heidelberg Im Neuenheimer Feld 364 D-69120 Heidelberg www.izn.uni-heidelberg.de Concept, Coordination and Editorial Office: Dipl.-Biol. Ute Volbehr Susanne Kilian M.A. Cover illustration by Simon Wiegert, Neurobiology, IZN: Dr. Otto Bräunling Depth-coded maximum z-projection of hippocampal CA1- neurons expressing Dronpa-labelled ERK1. The colour-spectrum from violet to red was used to artificially colour-code the position Production and Layout: of neurons in z-direction. Rolf Nonnenmacher, Dipl. Designer (FH) Image Sources: Sven Weimann Images were provided by the IZN Investigators and the Heidelberg University Hospital Media Center, the University of Heidelberg, the German Cancer Research Institute, Photolab/European Printed by: Molecular Biology Laboratory, Max Planck Institute for Medical Research, and Central Institute for Mental Health Mannheim. CITY-DRUCK HEIDELBERG 2 Table of Contents Table of Contents Boards 5 Thomas Kuner 93 Siegfried Mense 96 Research groups / IZN-Investigators 6 Andreas Meyer-Lindenberg 99 Concept and strucure of the IZN 9 Hannah Monyer 101 Appointments 14 Ulrike Müller 104 Christof Niehrs 107 Awards 16 Sabina Pauen 110 IZN Funding and grant giving bodies 18 Gabriele Elisabeth Pollerberg 113 Gudrun Rappold 116 Guest scientists 19 André Rupp 119 Collaborations 21 Martin Schmelz 122 Research Groups 35 Gerhard Schratt 124 Detlev Arendt 36 Christoph Schuster 127 Hilmar Bading 39 Günther Schütz 130 Dusan Bartsch 42 Markus Schwaninger 134 Martin Bohus 45 Peter H. Seeburg 136 Francesca Ciccolini 48 Horst Simon 137 Andreas von Deimling 51 Thomas Söllner 140 Winfried Denk 54 Rainer Spanagel 143 Andreas Draguhn 55 Hartwig Spors 147 Uwe Ernsberger 58 Rolf Sprengel 150 Thomas Euler 61 Kerry Tucker 153 Christian Fiebach 64 Klaus Unsicker 156 Herta Flor 67 Wolfgang Wick 159 Stephan Frings 70 Otmar D.
  • Life Changing Science

    Life Changing Science

    LIFE CHANGING SCIENCE The Francis Crick Institute Annual Review 2017/18 AN INSTITUTE FOR DISCOVERY Our commitment to excellence, our emphasis on multidisciplinary research, our focus on young and emerging talent and our novel ways of partnership working are some of the factors that set the Crick apart. Front cover Vaccinia virus infection (green) disrupts a layer of epithelial cells (red/blue). Courtesy of Michael Way, Group Leader at the Crick. INTRODUCTION 2 Who we are Our year at a glance 2 Introduction by Paul Nurse 4 The Francis Crick Institute is a biomedical Progress against our strategy 6 discovery institute dedicated to understanding the RESEARCH HIGHLIGHTS 10 Cancer-causing mutation fundamental biology underlying health and disease. suppresses immune system 11 Our work is helping to build an understanding of Predicting lung cancer’s return 12 New understanding of human why disease develops and to translate discoveries embryo development 14 Chemical attraction could improve into new ways to prevent, diagnose and treat cancer immunotherapy 16 illnesses such as cancer, heart disease, stroke, Genes linked to malaria parasites’ persistence 17 infections and neurodegenerative diseases. Architecture of our ‘second brain’ 18 Cause of infertility side-stepped in mice 19 Mechanism for spinal cord development discovered 20 A new layer of complexity in embryo development 21 Two DNAs wedded with this ring 22 Unravelling how DNA gets copied 23 Telomerase’s dark side discovered 24 REVIEW OF THE YEAR 26 New group leaders arrive 27 Joined-up thinking 30 Focusing on the molecules of life 32 CryoEM at the Crick 34 Bringing academia and industry closer together 36 The people making research happen 38 Patterns in art and science 40 Rewarding research 42 Appointments 43 Supporting new discoveries 44 Our vision What’s inside Our vision is to be a world- We bring together outstanding scientists Science feature 32 leading multidisciplinary from all disciplines and carry out research Sophisticated microscopy is being biomedical research institute.
  • Charles Swanton MRCP Bsc Phd Fibiol

    Charles Swanton MRCP Bsc Phd Fibiol

    Charles Swanton MRCP BSc PhD Biography Charles completed the MDPhD programme at University College London in 1999 having gained his PhD from the laboratory of Nic Jones at the Imperial Cancer Research Fund Laboratories establishing the subversion of cell cycle control by the Kaposi’s Sarcoma Herpesvirus encoded K-Cyclin (Swanton et al. Nature 1997) and was awarded the national Pontecorvo Imperial Cancer Research Fund PhD thesis award (Mann et al., 1999; Swanton et al., 1999; Swanton et al., 1997). Charles continued his interest in cell cycle disruption in cancer and its therapeutic applications (Swanton, Lancet Oncology 2004) and was made a Member of the Royal College of Physicians in 2003 and subsequently undertook his medical oncology training at the Royal Marsden Hospital. He was awarded a Cancer Research UK (CR-UK) clinician scientist fellowship in 2004 which allowed him to conduct his post-doctoral research training at the CR-UK London Research Institute with Prof Julian Downward, establishing multi-drug sensitivity mechanisms through RNA interference screening approaches, associated with paclitaxel and other common chemotherapy agents used in oncological practice (Swanton et al., 2007a; Swanton et al., 2007b). These screening datasets resulted in the observation that molecules that mediate chromosomal stability appeared to be significantly associated with those mediating taxane sensitivity and led to the first phase II clinical trial in colorectal cancer to attempt to define prospectively whether tumour chromosomal instability status alters response to a taxane-like drug. In 2008, Charles was awarded an MRC and a CR-UK senior clinical research fellowship and appointed MRC/CR-UK Group leader of the Translational Cancer Therapeutics Laboratory at the CRUK London Research Institute and Fellow of the Society of Biologists (FSB).
  • Cancer Research UK Gurdon Institute Prospectus 2020/2021 25 YEARS

    Cancer Research UK Gurdon Institute Prospectus 2020/2021 25 YEARS

    The Wellcome/ Cancer Research UK Gurdon Institute Prospectus 2020/2021 25 YEARS The Wellcome/ Cancer Research UK Gurdon Institute Studying Prospectus 2020/2021 E development to C U G E N D E R E R understand disease C HA R T The Gurdon Institute 3 Contents Welcome Welcome to our new Prospectus, where we highlight our Watermark, the first such award in the University. Special activities for - unusually - two years: 2019 and 2020. The thanks for this achievement go to Hélène Doerflinger, COVID-19 pandemic has made it an extraordinary time Phil Zegerman and Emma Rawlins. Director’s welcome 3 Emma Rawlins 38 for everyone. I want to express my pride and gratitude for the exceptional efforts of Institute members, After incubating Steve Jackson's company Adrestia in About the Institute 4 Daniel St Johnston 40 who have kept our building safe and our research the Institute for two years, we wished them well as they progressing; this applies especially to our core team, moved to the Babraham Research Campus. We also sent COVID stories 6 Ben Simons 42 whose dedication has been key to our best wishes to Meri Huch and our continued progress. As you will Rick Livesey and their labs, as they Highlights in 2019/2020 8 Azim Surani 44 see, there is much to be excited embarked on their new positions in about in our research and activities. Dresden and London, respectively. Focus on research Iva Tchasovnikarova 46 It was terrific to see Gurdon I'm delighted that Emma Rawlins Group leaders Fengzhu Xiong 48 members receive recognition for was promoted to Senior Group their achievements.