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Present Post: Previous Positions Held: Honors/Awards Membership In CURRICULUM VITAE Name: Vassilis Pachnis, M.D., Ph.D., FMedSci Date of Birth: 24 January 1953 Place of Birth: Athens, Greece Contact details: National Institute for Medical Research Institute of Molecular Biology and Biotechnology The Ridgeway, Mill Hill, Foundation for Research and Technology‐Hellas London NW7 1AA, UK. N. Plastira 100, GR‐70013, Heraklion, Greece tel. (+44) 02088162113 Tel. (+30) 2810391100 email: [email protected] Email: [email protected] Education: July 1980 University of Athens Medical School (Athens, Greece) M.D. magna cum laude June 1986 University of Pennsylvania, Philadelphia, PA (USA) Degree: Ph.D., Genetics Supervisor: Prof. Shirley Tilghman Nov 1986 – Mar 1988 Howard Hughes Medical Institute Center for Neurobiology and Behavior Columbia University, New York, NY (USA) Postdoctoral Fellow in Prof. Richard Axel's laboratory Apr 1988 – May 1991 Department of Genetics and Development Columbia University, New York, NY (USA) Postdoctoral fellow in Dr. Frank Costantini's laboratory Present Post: ‐ Head of Division of Molecular Neurobiology, National Institute for Medical Research, Medical Research Council (London, UK) ‐ Director of the Institute of Molecular Biology and Biotechnology of the Foundation for Research and Technology‐Hellas (Heraklion, Greece) Previous positions held: May 1991 – Feb 1997 Senior Scientific Staff, Group Leader, MRC National Institute for Medical Research, London (5/91‐2/97) Feb 1997 – Aug 2000 Tenured Senior Scientist, MRC National Institute for Medical Research, London Honors/Awards ‐ Scholarship from the National Scholarship Foundation of Greece for Academic excellence in Medical School ‐ Special Fellowship Award from the Leukemia Society of America (Jul 1989‐May 1991) ‐ Janssen Award for Life Time Achievement in Gastroenterology (2002) Membership in Academies ‐ Elected Fellow of the Academy of Medical Sciences, UK (2000). ‐ Elected member of EMBO (2007) Committees and other Professional Responsibilities ‐ Member of Review Panel for the Evaluation of the Pasteur Institute (Athens, 2004) ‐ Member of Review Panel for the Evaluation of the Institute of Biology at the Research Centre “Democritos” (Athens, 2005)‐ Chairman K. Sekeris ‐ Member of Review Panel for the evaluation of IIBEAA (Athens, 2007)‐ Chairman G. Stmatoyanopoulos ‐ Member of Review Panel for the evaluation of CSIC Institutes (Spain) (2009)‐ Chairman I. Mattaj. ‐ Member of BBSRC panel for assessment of grant applications. ‐ Frequent reviewer of manuscripts submitted to International peer review Journals. Meeting organisation ‐ Co‐organiser of an EMBO Workshop on Haematopoiesis and Neurogenesis (September 2007, Heidelberg). ‐ Organizer of the 2nd International Conference on ENS Development: Genes, Molecules and Signals (February 2009, London). Publications: 1) Reid I. A., McDonald, M., Pachnis, V., and Ganong, W. F. Studies concerning the mechanism of suppression of renin secretion by clonidine. The Journal of Pharmacology and Experimental Therapeutics 192, 713‐721, 1975. 2) Pachnis, V., Belayew, A., and Tilghman, S. M. Locus unlinked to ‐fetoprotein under the control of the murine raf and Rif genes. Proc. Natl. Acad. Sci. USA 81, 5523‐5527, 1984. 3) Tilghman, S. M., Belayew, A., Pachnis, V., and Krumlauf, R. Genetic approaches to the regulation of ‐ fetoprotein synthesis: ‐fetoprotein and Genetic Disorders. p53‐46 Academic Press, 1985. 4) Pachnis, V., Belayew, A., and Tilghman, S. M. Studies into the raf and Rif genes. Current Topics in Microbiology and Immunology 122, 50‐52, 1985. 5) Pachnis, V., Brannan, C. I., and Tilghman, S. M. The structure and expression of a novel gene activated in early mouse embryogenesis. The EMBO 7, 673‐681, 1988. 6) Yoo‐Warren, H., Pachnis, V., Ingram, R. S., and Tilghman, S. M. Two regualtory domains flank the H19 gene. Mol. Cell. Biol. 8, 4707‐4715, 1988. 7) Pachnis, V., Pevny, L., Rothstein, R., and Costantini, F. Transfer of a yeast artificial chromosome carrying human DNA from Saccharomyces cerevisiae into mammalian cells. Proc. Natl. Acad. Sci. USA 87, 5109‐5113, 1990. 8) Pachnis, V., Pevny, L., Rothstein, R., and Costantini, F. Transfer of a Yeast Artificial Chromosome (YAC) into cultured cells: a new method for manipulating the mammalian genome. Mechanisms of Eukaryotic DNA Recombination (Academic Press, N.Y.) 1992. 9) Pachnis, V., Mankoo, S. B. and Costantini, F. Expression of the c‐ret proto‐oncogene during mouse embryogenesis. Development 119, 1005‐1017 (1993). 10) Schuchardt, A., D'Agati, V., Larsson‐Blomberg, L., Costantini, F., and Pachnis, V. Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Nature 367, 380‐383 (1994). 11) Schuchardt, A., Srinivas, S., Pachnis, V. and Costantini, F. Isolation and Characterization of a Chicken Homologue of the c‐ret proto‐oncogene. Oncogene 10, 641‐649 (1995). 12) Grigoriou, M., Kastrinaki, M‐C, Modi, W., Theodorakis, K., Mankoo, B., Pachnis, V. and Karagogeos, D. Isolation of the human MOX‐2 Homeobox gene and Localization to chromosome 7p22.1‐p21.3. Genomics 26, 550‐555 (1995). 13) Pachnis, V., Durbec, P., Larsson‐Blomberg, L., Mankoo, B., Schuhardt, A., D'Agati, V. and Costantini, F. Knock‐out mice for the RET oncogene. In Molecular Genetics of Cancer. Ed. J.K. Cowell. Bios Scientific Publishers, Oxford. (1995). 14) Schuchardt, A., D'Agati, V., Larsson‐Blomberg, L., Costantini, F., and Pachnis, V. RET‐deficient mice: an animal model for Hirschsprung's disease and renal agenesis. J. Int. Medic. 238, 327‐332 (1995). 15) Durbec, P., Larsson‐Blomberg, L., Schuchardt, A., Costantini, F. and Pachnis, V. Common origin and developmental dependence on c‐ret of subsets of enteric and sympathetic neuroblasts. Development 122, 349‐358 (1996). 16) Schuchardt, A., D'Agati, V., Pachnis, V. and Costantini, F. Renal agenesis and hypodysplasia in ret.k‐ mutant mice result from defects in ureteric bud development. Development 122, 1919‐1929 (1996). 17) Durbec, P., Marcos‐Gutierrez, C., Kilkenny, C., Grigoriou, M., Suvanto, P., Smith, D., Ponder, B., Costantini, F., Saarma, M., Sariola, H. and Pachnis, V. Glial cell line‐derived neurotrophic factor signalling through the Ret receptor tyrosine kinase. Nature 381, 789‐793 (1996). 18) M. Trupp, E. Arena, M. Fainzilber, A‐S. Nilsson, B‐A. Sieber, M. Grigoriou, C. Kilkenny, E. Salazar‐ Grueso, V. Pachnis, Arumae, U., H. Sariola, M. Saarma and C. Ibanez. Functional receptor for glial cell line‐derived neurotrophic factor encoded by the c‐ret proto‐oncogene. Nature 381, (1996). 19) Rothman, T.P., Chen, J., Howard, M.J., Costantini, F., Schuchardt, A., Pachnis, V. and Gershon, M.D. Increased Expression of Laminin‐1 and Collagen (IV) Subunits in the Aganglionic Bowel of ls/ls, but Not c‐ret ‐ /‐ Mice. Developmental Biology 178, 498‐513 (1996). 20) Marcos C. and Pachnis V. The effect of the ret‐ mutation on the normal development of the central and parasympathetic nervous systems. Int J Dev Biol.137S‐138S (1996). 21) Burton, M.D., Kawashima, A., Brayer J.A., Kazemi, H., Shannon, D.C., Schuchardt, A., Costantini, F., Pachnis, V. and Kinane, T.B. RET proto‐oncogene is important for the development of respiratory CO2 sensitivity. Journal of the Autonomic Nervous System 63, 137‐143 (1997). 22) Sainio K, Suvanto P, Davies J, Wartiovaara J, Wartiovaara K, Saarma M, Arumae U, Meng X, Lindahl M, Pachnis V, Sariola H. Glial‐cell‐line‐derived neurotrophic factor is required for bud initiation from ureteric epithelium. Development 124, 4077‐4087 (1997). 23) Marcos‐Gutierrez CV, Wilson SW, Holder N, Pachnis V. The zebrafish homologue of the ret receptor and its pattern of expression during embryogenesis. Oncogene 14, 879‐889 (1997). 24) Schuchardt, A., Durbec, P., Marcos‐Gutierrez, C.V., Pachnis, V. and Costantini, F. “The role of the ret receptor tyrosine kinase and glial cell line‐derived neurtrophic factor in development of the excretory and peripheral nervous system”. In: “Epithelial Morphogenesis and Disease”. W. Birchmeier and C. Birchmeier, eds, Harwood Academic Publishers (1997). 25) Grigoriou, M., Tucker, A.S., Sharpe, P. and Pachnis, V. Expression and regulation of Lhx6 and Lhx7, a novel subfamily of LIM homeodomain encoding genes, suggests a role in mammalian head development. Development 125, 2063‐2074 (1998). 26) Wynick D, Small CJ, Bacon A, Holmes FE, Norman M, Ormandy CJ, Kilic E, Kerr NCH, Ghatei M, Talamantes F, Bloom SR & Pachnis V. Galanin regulates of prolactin release and lactotroph growth. Proc. Natl. Acad. Sci. USA 95, 12671‐12676 (1998). 27) Attie‐Bitach, T., Abitbol, M., Gerard, M., Delezoide, A.L., Auge, J., Pelet, A., Amiel, J., Pachnis, V., Munnich, A., Lyonnet, S., Vekemans, M. Expression of the RET proto‐oncogene in human embryos. Am J Med Genet. 80, 481‐6 (1998). 28) Wynick D, Small CJ, Bloom SR, Pachnis V Targeted disruption of the murine galanin gene. Ann N Y Acad Sci 863,22‐47 (1998). 39) Pachnis V, Durbec P, Taraviras S, Grigoriou M, Natarajan D. Role Of the RET signal transduction pathway in development of the mammalian enteric nervous system. Am J Physiol. 275 (2 Pt 1):G183‐6 (1998). 30) Tucker, A.S., Yamada, G., Grigoriou, M., Pachnis, V. and Sharpe, P.T. Fgf‐8 determines rostral‐caudal polarity in the first branchial arch. Development 126, 51‐61 (1999). 31) Natarajan, D., Grigoriou, M., Marcos‐Gutierrez, C.V., Atkins, C. and Pachnis, V. Multipotential progenitors of the mammalian enteric nervous system capable of colonising aganglionic bowel in organ culture. Development 126, 157‐168 (1999). 32) Taraviras S, Marcos‐Gutierrez CV, Durbec P, Jani H, Grigoriou M, Sukumaran M, Wang LC, Hynes M, Raisman G, Pachnis V. Signalling by the RET tyrosine kinase receptor and its role in the development of the mammalian enteric nervous system Development 126, 2785‐2797 (1999). 33) Taraviras S, Pachnis V.. Development of the Mammalian Enteric Nervous System Current Opinion in Genetics & Development 9, 321‐327 (1999). 34) Mankoo BS, Collins NS, Ashby P, Grigorieva E, Pevny LH, Candia A, Wright CV, Rigby PW, Pachnis V. Mox2, is a component of the genetic hierarchy controlling limb muscle development. Nature 400, 69‐ 73 (1999).
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