Authors: Ron Caspi Pedro R. Romero Peter D. Karp Carol Fulcher Jonathan Wagg

Markus Krummenacker Dan Weaver HumanCyc: Homo sapiens Cellular Overview Peter E Midford Dheepika Weerasinghe a monocarboxylate a monocarboxylate a monocarboxylate UDP-N- UDP-N- lactate lactate lactate chloride α acetyl-α-D- acetyl-α-D- acetate acetate acetate (R)- β UDP-N-acetyl-D-galactosamine UDP- -D-glucose borate Zn 2+ hydrogencarbonate serotonin trp -D- phos UDP-α-D-glucuronate UDP-N-acetyl-α-D-glucosamine glucosamine glucosamine [+ 3 more] [+ 3 more] [+ 3 more] noradrenaline glucopyranose a sphingomyelin β a -D-glucosyl-N-acylsphingosine a phosphatidylcholine a phosphatidylethanolamine arsenous arsenous arsenous Scavenger GTPase- a phosphatidylcholine Vesicle- FYVE, Ras-specific Nucleotide- Sprouty- acid acid acid F-box/ receptor Rho activating Rho Sodium- Mixed CUB and Sod UDP-glucuronic associated Late RhoGEF UDP-xylose TBC1 GRAM Ly6/PLAUR HLA class I Putative Probable Rho HERV- Ly6/PLAUR guanine binding Putative related, Leucine- Leucine- Probable Transmembrane Probable Heat shock- HLA class I Limb region SPRY G-protein BCL-6 UDP-N- SH3KBP1- CMP- MARCKS- G-protein cysteine- Ras-related guanine E3 ubiquitin- protein Extracellular Phosphoinositide Olfactory Multidrug Caveolae- guanine Olfactory Chloride Protein Olfactory Immunoglobulin Myotubularin- Olfactory Olfactory GTP- Transmembrane Protein and chloride- Protein lineage Immunoglobulin Protein sushi depen Immunoglobulin acid/UDP-N- membrane cornified and PH and UDP-N- Protein domain Protein Phospholipid Integrin domain- domain- histocompatibility olfactory G-protein GTPase- H LTR- domain- nucleotide- oligomerization Olfactory olfactory Protocadherin EVH1 rich repeat- rich repeat- G-protein gamma- Protocadherin XK-related G-protein Olfactory related Olfactory histocompatibility Tetraspanin-31 A2MR p23 1 protein domain- coupled PRKA11 Tetraspanin-11 Battenin Annexin A8 corepressor- Cx26 CD284 HFRC1 acetylglucosamine CD204 hGAL TIAM-1 MDC-L Copine-7 p11 Rnd1 hRECK PAR-2 N14F EF-2 RGS22 binding Ten-2 sialic acid related GIP-R Oct-11 Fz-5 OXIDOREDUCTASE OTRPC1 DLK-2 ORP-6 coupled hTRPM4 ORP-4 rich domain- protein RGS2 nucleotide CD217 TAX-1 citrin OR9-C protein MARS FHL-1 CD49c KIP 2 Aw-43 EDC1 Protrudin ET-A and VPS9 matrix protein RAIG-3 5-HT3C Striatin-3 CD133 3-kinase adapter receptor Siah-1 GP78 Neogenin CD243 resistance associated MDC-3 NEDD-1 EDB NACP nucleotide NPY1-R Arfaptin-2 CD68 CD258 hFmi2 MCT 12 CD300b receptor MCT 1 MCT 3 MCT 2 NaBC1 ZnT-7 Plasminogen anion NBCe2 YIPF3, 36 Cx31.9 receptor CAS-L MCT 14 5HTT heavy constant related Bw-22 Amisyn Cyclin-Y receptor NET Cx46.6 receptor binding CD299 Cx46 channel-like Delphilin crumbs LAT2 CD265 dependent Ft1 CD261 GLUT-3 CD62L GLUT-1 AQP-9 AQPAP APH-1a spinster Glycophorin-E OST423 kinase lambda CX3CR1 hPen Contactin-1 Bw-44 CD300g CPX IV cornichon domain- Cnt-d3 Suppressyn phosp T cell kappa variable 1-5 acetylgalactosamine protein- envelope domain- acetylglucosamine lifeguard 2 family YIPF4 scramblase 3 alpha-11 containing containing antigen, A receptor coupled activating associating containing releasing domain- receptor 2L2 receptor alpha-6 domain- containing containing coupled carboxyglutamic beta-16 protein 9 coupled receptor 2F1 70 kDa receptor 1J4 antigen, B homolog containing receptor 20 like protein 1 transporter protein 1 transporter protein receptor 55 containing Rab-21 exchange ligase CBL domain- FRAS1 protein 1 10Q1 protein 3 protein 4 exchange 6B2 exchanger kDa form III 10H5 gamma 1 protein 6 2A7 2Y1 protein Rit2 protein 7 homolog 1 transporter homolog 2 domain- variable 3-1 homolog 3 containing tran receptor transporter associated protein 1C containing transporter member 3K protein 2A protein 6B alpha chain 2W5 receptor 150 protein 12 protein 2 protein 8 factor containing 2B8 containing protein 4 protein 40 receptor 149 acid protein 4 receptor 174 protein 2 alpha chain protein 1 group B factor 25 containing factor 39 XTRP3 like protein protein 3 prote beta protein B/C protein 5 RalGPS1 protein 2 a sphingomyelin protein 2 α protein protein 1 β constant 1 UDP- -D-glucose a β-D-glucosyl-N-acylsphingosine a monocarboxylate a monocarboxylate a monocarboxylate (R)- -D- arsenous arsenous arsenous borate Zn 2+ hydrogencarbonate serotonin UDP-N-acetyl-α-D-glucosamine UDP-N- a phosphatidylcholine lactate lactate lactate noradrenaline trp glucopyranose acid acid acid UDP-N-acetyl-D-galactosamine UDP-N- a phosphatidylethanolamine Immunoglobulin acetyl-α-D- acetate acetate acetate hydrogencarbonatechloride UDP-α-D-glucuronate acetyl-α-D- a phosphatidylcholine heavy glucosamine [+ 3 more] [+ 3 more] [+ 3 more] hydrogencarbonate phos variable 4-28 glucosamine

Adaptin

ear-binding coat- Aromatic Compound associated superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle thyronamine and iodothyronamine metabolism Hormone Degradation Biosynthesis protein 2 ATP biosynthesis

Carbohydrate Biosynthesis heparan sulfate biosynthesis dermatan sulfate biosynthesis gluconeogenesis α-dystroglycan glycosylation UDP-α-D-glucose chondroitin sulfate biosynthesis protein N-glycosylation initial phase (eukaryotic) protein O-mannosylation II protein O-mannosylation III (mammals, core M3) complex N-linked glycan biosynthesis (vertebrates) GDP-L-fucose 4-hydroxybenzoate D-glucopyranose Acetyl-CoA Biosynthesis GDNF family glycogen biosynthesis protein O-[N-acetyl]-glucosylation superpathway of cholesterol biosynthesis Fatty Acid and Lipid Biosynthesis 3,3',5,5'-tetraiodothyronamine plasmalogen biosynthesis α biosynthesis I (mammals, core M1 and core M2) biosynthesis II biosynthesis arachidonate myristate biosynthesis (mitochondria) palmitate biosynthesis (cytoplasm) very long chain fatty ultra-long-chain fatty docosahexaenoate biosynthesis anandamide biosynthesis I phosphatidylcholine biosynthesis allopregnanolone biosynthesis ADP receptor UDP- -D-xylose α α a 3-O-[N-acetyl-β- Man GlcNAc - dolichol and diacylglycerol and acylceramide biosynthesis α thyroid hormone metabolism I (via deiodination) UDP- -D-xylose UDP- -D-xylose 5 2 (from L-fucose) acid biosynthesis II acid biosynthesis + -D-glucopyranose (S)-malate D-ribitol 5- GDP-α-D-mannose biosynthesis V (8- III (6-desaturase, mammals) H -translocating V- ketolysis alpha-3 D-glucopyranose a dolichyl phosphate D-galactosaminyl- UDP-α-D-glucose GDP-α-D-mannose [protein] (isomer 5A ) a [glycoprotein]-(L- acetyl-CoA dolichyl phosphate an acetoacetyl-[acp triacylglycerol biosynthesis 6-kinase: HK2 dolichyl-phosphate β-D 1,2 detaturase, mammals) 3,3',5,5'- protein 6-phosphate protein protein UDP-N-acetyl-α-D-glucosamine phosphate α β L-fucopyranose serine/L-threonine) tyr a long-chain fatty acyl-CoA arachidonoyl-CoA choline progesterone ATPase: ATP6V0A1 acetyl-CoA UDP-α-D- phosphoglucomutase: (1->3)-N-acetyl- UDP- -D- dolichyl-phosphate -D α-1,3-mannosyl-glycoprotein 2-β- biosynthesis an acetoacetyl-[acp] domain within a stearoyl-CoA cerotoyl-CoA (5Z,8Z,11Z,14Z,17Z) triacontanoyl-CoA α-D-glucopyranose tetraiodothyronamine L-thyroxine xylosyltransferase: xylosyltransferase: -mannosyltransferase: L-fucose tyrosine sn-glycerol progesterone 5α- ATP6V0D1 ATP6V0C biosynthesis xylosyltransferase: PGM2 malate β-D-glucosaminyl- D-ribitol-5-phosphate glucose:glycogenin α- -mannosyltransferase: N-acetylglucosaminyltransferase: linoleoyl-CoA acetyl-CoA (2E,6E)-farnesyl fatty acid synthase] 3-oxoicosanoyl- -icosapentaenoyl-CoA Ethanolamine kinase: CHKB (R)-3-hydroxybutanoate GMIP galactose DPM2 DPM3 DPM1 3-oxooctacosanoyl- 3-oxo-docosapentaenoyl- 6-kinase: HK3 5-deiodinase: DIO3 XYLT1 XYLT1 XYLT1 cytidylyltransferase: kinase: aminotransferase: (11Z,14Z)-3- acetyltransferase: ACAT2 3-phosphate reductase: SRD5A2 ATP6V0B ATP6V0E1 from citrate UDP-N-acetylglucosamine- dehydrogenase: (1->4)-6- D-glucosyltransferase: DPM2 DPM3 DPM1 MGAT1 [protein]-3-O diphosphate acetoacetyl- CoA synthase: choline kinase: CHKA Acyl-coenzyme α-D-glucopyranose 3-hydroxybutyrate 3,3',5-triiodothyronamine phosphoglucomutase: a dolichyl β-D- a dolichyl β-D-mannosyl phosphate FCSK TAT dehydrodolichyl CoA synthase: ELOVL4 CoA synthase: ELOVL2 ATP6V1A ATP6V1B2 Type III L-thyroxine 5'- L-thyroxine 5- noradrenaline and adrenaline degradation protein protein protein -dolichyl-phosphate N- pyruvate phospho-α-D- CRPPA GYG1 -(N-acetyl-D- 3-(4-hydroxyphenyl) oxoicosadienoyl- acetyl-CoA ELOVL7 glycerol 3- phosphocholine A thioesterase progesterone 5α- dehydrogenase: BDH2 citrate PGM1 MDH1 mannosyl phosphate β-L-fucose UDP-N- [acyl-carrier 3-oxooctacosanoyl-CoA 3-oxo-icosapentaenoyl- Fatty acyl-CoA 6-kinase: HK1 iodothyronine α-D-glucopyranose xylosyltransferase: Man GlcNAc -[protein] diphosphate 3-oxoicosanoyl- ATP6V1C1 ATP6V1D deiodinase: DIO2 deiodinase: DIO3 xylosyltransferase: xylosyltransferase: acetylglucosaminephosphotransferase: mannosyl)]-Ser/ α 5 3 β pyruvate CoA synthase: acetyltransferase: ACAT1 8: ACOT8 reductase: SRD5A1 ATP-citrate malate UDP- -D- dolichyl-phosphate- 1-phosphate glucosaminyl)-L- acetylglucosamine:glycoprotein - protein] a (3R)-3- phosphate glycerone-phosphate O- reductase 2: FAR2 3-hydroxybutyrate deiodinase: DIO3 Alpha- 1-phosphate XYLT2 CDP-ribitol synthase: CoA CoA synthase: ELOVL5 1-arachidinoyl-sn-glycerol 3-phosphate choline-phosphate 5α-pregnane-3,20-dione ATP6V1E1 ATP6V1F glucose Type I iodothyronine Type III (R)-noradrenaline XYLT2 XYLT2 DPAGT1 Thr-[protein] α serine/L-threonine ELOVL7 acyltransferase: (5Z,8Z,11Z,14Z,17Z)-3- [+ 2 isozymes] synthase: actinin-2 dehydrogenase: pyruvate glucose:glycogenin - mannose--protein mannosyl- N-acetylglucosaminyltransferase: (11Z,14Z)-3- reductase: hydroxybutanoyl- 3-oxooctacosanoyl-CoA acyltransferase: GNPAT long-chain acyl-CoA phosphorylase: HKDC1 dehydrogenase: BDH1 UDP-glucose β β fucose-1-phosphate α acetoacetyl-CoA di-trans, poly-NUS1 DHDDS 3-oxoicosanoyl- oxodocosapentaenoyl-CoA cytidylyltransferase: PCYT1A ATP6V1G1 ATP6V1H ACLY deiodinase: DIO1 iodothyronine a 3-O-( -D- a 3-O-( -D-xylosyl) D-glucosyltransferase: O-N-acetyl- -D- OGT CBR4 GPAM acetoacetate β α MDH2 carboxylase: mannosyltransferase: oligosaccharide 1,3- oxoicosadienoyl-CoA cis-polyprenyl [acp domain within reductase: HSD17B12 reductase: FAR1 3α-hydroxysteroid β-D-glucopyranose a 3-O-( -D- pyrophosphorylase: xylosyl)-L- UDP-α-D-galactose N-acetyl- -D-glucosaminyl- β guanylyltransferase: CoA reductase: Choline-phosphate triacontanoate acetyl-CoA 3,3',5'-triiodothyronamine 3,5-diiodothyronamine deiodinase: DIO3 -L-seryl-[protein] βGalNAc- GYG2 a dolichyl -D- POMT2 POMT1 α glucosaminase: OGA hydroxymethylglutaryl- HSD17B8 [+ 3 isozymes] 3-oxodocosapentaenoyl- FoF ATP synthase: noradrenaline O- amine oxidase: MAOA noradrenaline N- xylosyl)-L- diphosphodolichol [+ 3 isozymes] PC 1,6- -mannosidase: FPGT (R)-3-(4- diphosphate (C ) a fatty acid synthase] HSD17B12 dehydrogenase: AKR1C4 1 6-kinase: GCK Relaxin-3 UGP2 seryl-[protein] an α-D-glucosyl- mannosyl phosphate 80 CoA reductase: cytidylyltransferase acetoacetate CoA- methyltransferase: PNMT (1->3)- MAN2A2 CoA synthase: HMGCS1 (3R)-3-hydroxyoctacosanoyl-CoA triacontanoate α ATP5PO ATP5PF 3,5,3'-triiodo-L-thyronine methyltransferase: COMT seryl-[protein] β a 3-O-(α-D-mannosyl)-(Ser/Thr)-[protein] hydroxyphenyl)lactate a (3R)-3- 5 -dihydroprogesterone UDP-galactose: - UDP-N- (3R)-3-hydroxy- a 2-lysophosphatidate HSD17B12 B: PCYT1B transferase: OXCT1 receptor 2 α βGlucNAc- [glycogenin] dolichyl-phosphate- GDP-β-L-fucose an N-acetyl-β-D- hydroxymethylglutaryl- hydroxybutanoyl-[acp] ω-hydroxylase: ATP5MG ATP5MF D-glucopyranose 6-phosphate 3,3',5'- 3,3',5'-triiodo-L-thyronine Transmembrane O- UDP- -D-glucose β acetylglucosamine oxaloacetate mannosyl- (3R,11Z,14Z)-3- arachidoyl-CoA a 1-long-chain acyl-glycerone 3-phosphate a long-chain fatty alcohol a 1-arachidonoyl-2-acyl-sn-glycerol 3-phosphate reductase: AKR1C3 3,4-dihydroxyphenylglycolaldehyde xylose -1,4- β enoyl-CoA ATP5ME ATP5PD succinyl-CoA:3- UDP-galactose:β- β (1->4)-P-6- α mannose--protein protein O-linked-mannose -1,4- glucosaminyl-[glycoprotein] CoA synthase: HMGCS2 (3R,5Z,8Z,11Z,14Z,17Z)-3- CDP-choline CYP4F22 α triiodothyronamine methyltransferase: LRTOMT (R)-adrenaline α UDP-galactose: - galactosyltransferase: transferase UDP- -D- oligosaccharide 1,3- hydroxyicosadienoyl- (3R)-3- a (2E)-but-2-enoyl- 1-acyl-sn-glycero- 3 -hydroxysteroid ketoacid-coenzyme A 3,3',5- 3,3',5'-triiodo- β UDP- -D- O-αMan- mannosyltransferase: N-acetylglucosaminyltransferase: a di-trans, poly- enoyl-CoA hydratase: HSD17B4 hydroxydocosapentaenoyl-CoA MT-ATP8 MT-ATP6 Glucose-6-phosphate 3-deiodinase: DIO3 xylose -1,4- xylose β-1,4- subunit ALG13 phosphoenolpyruvate glucose:glucosyl- 1,6-α-mannosidase: CoA hydroxybutanoyl- [acp domain within 3-phosphate phosphatidate dehydrogenase: AKR1C1 triiodothyronamine L-thyronine 3- PAR-6 galactose B4GALT7 [protein] POMT2 POMT1 POMGNT2 HMG-CoA cis-polyprenol hydratase: 1,2-diacyl-sn-glycerol 30-hydroxytriacontanoate ATP5PB ATP5MC3 isomerase: GPI transferase: OXCT2 adrenaline O- galactosyltransferase: α MAN2A1 enoyl-CoA acyltransferase: alkylglycerone- phosphatase: PLPP4 α Type III 3,3',5'- 5-deiodinase: DIO3 3,5- 3,4-dihydroxyphenylglycolaldehyde alcohol galactosyltransferase:a 3-O-[β-D- homolog: ALG13 carboxykinase: PCK1 glycogenin -D- 4-coumarate [acp] dehydratase: a fatty acid synthase] HSD17B4 trans-octacos-2-enoyl-CoA 3 -hydroxysteroid deiodinase: DIO3 normetanephrine ribitol 5- a 3-O-(α-D-mannosyl) a 3-O-[N-acetyl-β-D-glucosaminyl-(1->4) polyprenol phosphate [+ 6 isozymes] cholinephosphotransferase: ATP5MC2 ATP5MC1 diiodothyronamine 3,5-diiodothyronine 3,5,3'-triiodo- dehydrogenase: ALDH2 dehydrogenase: ADH6 methyltransferase: COMT B4GALT7 B4GALT7 galactosyl-(1->4) a 3-O-[β-D-galactosyl- N-acetyl-β-D-glucosaminyl- glucosyltransferase: hydratase: 3-hydroxy-3- HTD2 AGPAT1 30-hydroxytriacontanoyl- dehydrogenase: AKR1C2 F6P acetoacetyl-CoA iodothyronine triiodothyronamine Type III phosphoenol phosphate α Man GlcNAc -[protein] reductase: trans-arachido- CEPT1 ATPAF2 ATP5F1A -(Ser/Thr)-[protein] - -D-mannosyl)]-(Ser/Thr)-[protein] 3 3 synthase: AGPS 5-deiodinase: DIO3 L-thyronine 5- Type I iodothyronine3',5'-diiodothyronine 3,4-dihydroxyphenylglycolaldehyde 3,4-dihydroxyphenylglycolaldehyde Transmembrane O- α -β-D-xylosyl]-L- (1->4)-β-D-xylosyl]- (1->4)-N-acetyl-α-D- GYG1 HSD17B4 methylglutaryl-coenzyme trans-octacos-2-enoyl- [+ 11 isozymes] (2E,7Z,10Z,13Z,16Z,19Z) CoA synthetase: deiodinase: DIO3 5'-deiodinase: DIO2 iodothyronine β UDP- -D- pyruvate transferase: β β SRD5A3 2-enoyl-CoA a 1-arachidonoyl-2-acyl-sn-glycerol β α VPS9D1 ATPAF1 normetanephrine a 3-O-[ -D- UDP-α-D-galactose L-seryl-[protein] protein O-linked-mannose -1,2- -1,3-N- α β A reductase: HMGCR a (2E)-but-2-enoyl-[acp] Cholinephosphotransferase SLC27A4 3 -hydroxy-5 -pregnane-20-one 6-phosphofructokinase: PFKL acetyl-CoA Type III 3,5-diiodothyronine deiodinase: DIO3 deiodinase: DIO1 dehydrogenase: ALDH3A2 reductase: ADH4 methyltransferase: LRTOMT RAPH1 galactose seryl-[protein] glucosaminyl-diphosphodolichol UDP-α-D- -1,6-mannosyl-glycoprotein 2- - (2E,11Z,14Z)- CoA reductase: TECR -docosahexaenoyl-CoA Type I iodothyronine deiodinase: DIO3 deaminase: MAOB galactosyl-(1->4) phosphoglycerate FKTN a butanoyl-[acp a phosphatidate ATP5F1B ATP5F1C N-acetylglucosaminyltransferase: acetylgalactosaminyltransferase: trans- 1: CHPT1 6-phosphofructokinase: acetyltransferase: ACAT1 iodothyronine 5-deiodinase: DIO3 Type III 3,3',5'-triiodo- β Chitobiosyldiphosphodolichol glucose:glucosyl- N-acetylglucosaminyltransferase: ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide icosatrienoyl-CoA a dolichol ser a 1-alkyl-glycerone 3-phosphate ATP5F1D ATP5F1E 3',5'-diiodothyronamine deiodinase: DIO1 normetanephrine metanephrine - -D-xylosyl]-L- galactosylxylosylprotein 3- enolase: ENO1 POMGNT1 B3GALNT2 4-hydroxybenzaldehyde (R)-mevalonate (2E)-but-2- domain within a arachido-2- 30-hydroxytriacontanoyl-CoA PFKM deiodinase: DIO3 iodothyronine L-thyronine 5'- glycogenin α-D- MGAT2 octacosanoyl-CoA a phosphatidylcholine Type II iodothyronine 3,4-dihydroxymandelate 3,4-dihydroxyphenylglycol seryl-[protein] β beta-mannosyltransferase: ALG1 a 3-O-[Rbo5P-3- β β fatty acid synthase] phosphatidate ATP acetyl-CoA deaminase: MAOA Cation -galactosyltransferase: phosphoglycerate a 3-O-[ -D-GlcNAc- a 3-O-[N-acetyl- -D-galactosaminyl- Dolichol enoyl-[acp] enoyl-CoA 6-phosphofructokinase: PFKP deiodinase: DIO3 deiodinase: DIO2 Type I iodothyronine β-D-Man-(1->4)-β-D-GlcNAc-(1->4) β glucosyltransferase: phosphatase: 1-alkyl-glycerone 3- deiodinase: DIO2 channel B3GALT6 enolase: ENO2 GalNAc-(1->3)- (1->2)-α-D-mannosyl]- (1->3)-N-acetyl-β-D-glucosaminyl-(1->4) Man GlcNAc -[protein] an N-acetyl-β-D-glucosaminyl-R kinase: reductase: reductase: 3-oxotriacontanoyl- (7Z,10Z,13Z,16Z,19Z) a 1-arachidonoyl-2-acyl-sn 3-monoiodothyronine metanephrine galactosylxylosylprotein 3- α β GYG2 3 4 mevalonate kinase: MVK N-(30- (6R)-N-(30- N-(30- dihydroceramide Fermentation 3',5'- deiodinase: DIO1 catechol O- galactosylxylosylprotein 3- - -D-GlcNAc-diphosphodolichol GlucNAc-(1->4) (Ser/Thr)-[protein] -α-D-mannosyl]-(Ser/Thr)-[protein] (11Z,14Z)- TECR PLPP4 phosphate reductase -glycero-3-phosphocholine β-D-fructose 1,6-bisphosphate sperm- β-galactosyltransferase: phosphoglycerate β DOLK MECR CoA synthase: ELOVL4 -docosapentaenoyl-CoA hydroxytriacontanoyl) hydroxytriacontanoyl)- hydroxytriacontanoyl) synthase: CERS1 diiodothyronamine 3',5'-diiodothyronine methyltransferase: COMT deaminase: MAOB thyroid hormone metabolism II (via conjugation and/or degradation) β-galactosyltransferase: a 3-O-[β-D-galactosyl- DP-Man:Man GlcNAc -(P6)-O-αMan]- (1,4-α-D-glucosyl) β-D-GlcNAc-(1->2)-α-D-mannosyl- -N-acetylglucosaminylglycopeptide [+ 6 isozymes] associated 1 2 enolase: ENO3 n protein O-mannose α β β β α icosadienoyl-CoA a 3-oxohexanoyl- phosphatidylchole:phosphatidylethanolamine 5'-deiodinase: DIO2 metanephrine α B3GALT6 β β -1,3-mannosyl-glycoprotein 4- - -1,4-mannosyl-glycoprotein 4- - glycoprotein 6- -L- β-1,4-galactosyltransferase: (R)-5-phosphomevalonate a dolichyl arachidoyl-CoA 3-oxo- ethanolamine a 1-alkyl-sn-glycerol 3-phosphate -sphingosine 6-hydroxysphingosine -phytosphingosine ultra-long- 5'-deiodinase: DIO2 catechol O- Transmembrane O- B3GALT6 UDP- -D- (1->3)- -D-galactosyl- -PP-dolichol α-1,3- Ser/Thr-[protein] -glucosyl glucogenin O-(Ser/Thr)-[protein] 6- -N- 4-hydroxybenzoate a butanoyl-[acp] 3-oxotriacontanoyl-CoA pyruvate fermentation protein 2-phospho- Rbo5P-3- kinase: POMK N-acetylglucosaminyltransferase: N-acetylglucosaminyltransferase: fucosyltransferase: (11Z,14Z)- phosphate [acp domain within a 1,2-diacyl- tetracosapentaenoyl- N-arachidonoyltransferase: PLAAT2 synthase: CERS3 synthase: CERS3 synthase: CERS3 chain ceramide Type I iodothyronine methyltransferase: LRTOMT deaminase: MAOA glucuronate (1->4)-β-D-xylosyl]- mannosyltransferase: acetylglucosaminyltransferase: B4GALT1 to (S)-lactate methyltransferase: COMT L-thyroxine subunit β D-glycerate βGalNAc- a 3-O-[N-acetyl-β-D-galactosaminyl-(1->3) MGAT4C MGAT3 FUT8 icosa-11,14- a fatty acid synthase] sn-glycerol CoA synthase: ELOVL2 ethanolamine phosphatidylcholine:phosphatidylethanolamine fructose-bisphosphate 3,3'-diiodothyronine a 3-O-[ -D- UDP-α-D-glucuronate β-N-acetylglucosaminylglycopeptide phosphomevalonate 3-oxotriacontanoyl-CoA 1-alkyl-sn-glycero- synthase: CERS3 deiodinase: DIO1 Transmembrane O- epsilon L-seryl-[protein] ALG2 MGAT5B β dienoyl-CoA 3-oxohexanoyl- kinase: ETNK1 N-arachidonoyltransferase: PLAAT1 3,3'-diiodothyronamine 3-methoxy-4-hydroxyphenylglycol galactosyl- 2,3-bisphosphoglycerate- (1->3)- a 3-O-{β-D-GlcNAc- -N-acetyl- -D-glucosaminyl-(1->4)-6- α-1,3-mannosyl-glycoprotein 4-β- β kinase: PMVK 2-acylglycerol O- (9Z,12Z,15Z,18Z,21Z)-3- 3-phosphate N-(30-hydroxytriacontanoyl) N-(30-hydroxytriacontanoyl) N-(30-hydroxytriacontanoyl) aldolase: ALDOC Type II iodothyronine 3-momoiodothyronine β α β β α 4 β α -1,4-galactosyltransferase: [acyl-carrier- reductase: HSD17B12 pyruvate methyltransferase: LRTOMT β a 3-O-[ -D- -D-Man-(1->3)- -D-Man- dependent βGlucNAc- a glucosylated phospho-α-D-mannosyl)]-Ser/Thr-[protein] a { -D-GlcNAc-(1->2)- -D- an N -{ -D-GlcNAc-(1->2)- -D- 8-desaturase: acyltransferase [+ 2 isozymes] acyltransferase: AGPAT1 phosphatidylchole:phosphatidylethanolamine -sphingosine -(6R)-6-hydroxysphingosine -phytosphingosine fructose-bisphosphate 3-deiodinase: DIO3 3-methoxy-4-hydroxyphenylglycolaldehyde alcohol L-thyroxine 5'- UDP- UDP- L-thyroxine (1->3)- -D- galactosylgalactosylxylosylprotein 3- β α (1->2)-[β-D-GlcNAc- N-acetylglucosaminyltransferase: B4GALT3 oxotetracosapentaenoyl-CoA N-(30-hydroxytriacontanoyl) L-lactate deiodinase: DIO2 galactosyl- (1->4)- -D-GlcNAc-(1->4)- - glycogenin Man-(1->3)-[β-D-GlcNAc- Man-(1->3)-[β-D-GlcNAc-(1->2)-α- FADS2 protein] 3-oxobehenoyl- N-arachidonoyltransferase: PLAAT5 dehydrogenase: ADH6 glucuronosyltransferase glucuronosyltransferase sulfotransferase: galactosyl-(1->4) β phosphoglycerate (1->4)-P-6- (1->6)-]-α-D-mannosyl}- MGAT4B (R)-mevalonate diphosphate a (3R)-3- (3R)-3-hydroxytriacontanoyl-CoA 3: MOGAT3 triglyceride:N-(30- triglyceride:(6R)-N-(30- triglyceride:N-(30- -sphinganine aldolase: ALDOA dehydrogenase: LDHB 3,3'- deiodinase: Semaphorin-4B (1->3)-β-D- -glucuronosyltransferase: B3GAT1 D-GlcNAc-diphosphodolichol (1->2)-α-D-Man-(1->6)]-[β- D-Man-(1->6)]-β-D-Man-(1->4)-β- β-N-acetylglucosaminylglycopeptide synthase: CoA O-phosphoethanolamine -β-D-xylosyl]-L- mutase: PGAM2 O-αMan- UDP- dihomo γ- hydroxyhexanoyl- [+ 3 isozymes] a 2-acyl-1-alkyl-sn-glycerol 3-phosphate fructose-bisphosphate diiodothyronamine 3-methoxy-4- DIO2 2B11 precursor, 2B11 precursor, SULT1A2 galactosylgalactosylxylosylprotein 3- GDP-Man:Man GlcNAc (Ser/Thr)-[protein] α-1,3-mannosyl-glycoprotein 4-β- β α β-1,4-galactosyltransferase: OXSM hydroxytriacontanoyl) hydroxytriacontanoyl)- hydroxytriacontanoyl) triglyceride:N-(30- L-lactate 3,3'-diiodothyronine galactosyl-(1->4) 2 2 glucose:glycogenin D-GlcNAc-(1->4)]- -D-Man- D-GlcNAc-(1->4)-[ -L-Fuc-(1->6) 3-oxobehenoyl- choline an N-arachidonoyl-phosphatidylethanolamine 3-methoxy-4- tetraiodothyroacetate 3-iodothyronamine seryl-[protein] 2,3-bisphosphoglycerate- [protein] linolenoyl-CoA diphosphomevalonate [acp domain within enoyl-CoA -sphingosine 6-hydroxysphingosine -phytosphingosine aldolase: ALDOB 3-deiodinase: DIO3 hydroxyphenylglycol Type I microsomal: UGT2B11 microsomal: UGT2B11 L-thyroxine β α β-glucuronosyltransferase: B3GAT3 -PP-dolichol α-1,6- α N-acetylglucosaminyltransferase: β β B4GALT2 a triacyl-sn ethanolamine- hydroxytriacontanoyl) dehydrogenase: LDHC 3-deiodinase: DIO3 hydroxyphenylglycolaldehyde - -D-xylosyl]-L- UDP- -D- ribitol 5- 4- -D- (1->4)- -D-GlcNAc-(1->4)- ]- -D-GlcNAc}-N-Asn-[protein] a fatty acid synthase] CoA hydratase: HSD17B4 (3R,9Z,12Z,15Z,18Z,21Z)-3- 2-acyl-1-alkyl-sn- dehydrogenase: ADH1B sulfotransferase: mannosyltransferase: dependent MGAT4A β icosatrienoyl- decarboxylase: MVD a 3-oxohexanoyl-[acp] -glycerol phosphate Ethanolamine linoleoyltransferase: linoleoyltransferase: linoleoyltransferase: -sphinganine L-lactate Type III iodothyronine seryl-[protein] glucuronate galactosylgalactosylxylosylprotein 3- phosphate glucosyltransferase: -D-GlcNAc}-N-Asn-[protein] a type 2 histo-blood group reductase: hydroxytetracosapentaenoyl-CoA glycerol 3-phosphate triosephosphate dehydrogenase: ALDH3A2 L-thyroxine phenolic L-thyroxine acyl CLIM-1 galactosylgalactosylxylosylprotein 3- phosphoglycerate CoA 5- cytidylyltransferase: kinase: CHKB N-arachidonoyl- N-arachidonoyl- PNPLA1 PNPLA1 PNPLA1 linoleoyltransferase: iodothyronine deiodinase: SULT1A1 UDP- UDP- β-glucuronosyltransferase: B3GAT2 ALG2 GYS1 antigen precursor disaccharide HSD17B12 phosphohydrolase isomerase: TPI1 dehydrogenase: LDHA β β β-glucuronosyltransferase: B3GAT1 α α mutase: PGAM1 transferase: a {β-D-GlcNAc-(1->2)-[β-D- desaturase: IPP trans-triaconta-2-enoyl-CoA enoyl-CoA choline kinase: CHKA phosphatidylethanolamine- phosphatidylethanolamine sn PNPLA1 deiodinase: DIO3 DIO1 -D-glucuronide -D-glucuronide Sulfotransferase glucuronosyltransferase glucuronosyltransferase galactosylgalactosylxylosylprotein 3- -D-Man-(1->3)-[ -D-Man- 3-oxotehexanoyl- (3R)-3- PCYT2 DHAP D-glyceraldehyde 3-phosphate (S)-lactate FKRP α ceramide E(C30:0)OS(C18:1) ceramide E(C30:0)OH(C18:1) ceramide E(C30:0)OP(C18:0) galactosylgalactosylxylosylprotein 3- a 3-O-[β-D-GlcA- (1->6)]-α-D-Man-(1->4)- glycogen GlcNAc-(1->4)]- -D-Man- FADS1 [acyl-carrier hydratase: HSD17B4 a 2-acyl-1-alkyl-sn-glycerol hydrolysing -2 acylhydrolase: PLA2G1B an N-arachidonoyl-1- 1A1: SULT1A1 2B11 precursor, 2B11 precursor, β-glucuronosyltransferase: B3GAT1 2,3-bisphosphoglycerate- a 3-O-[Rib-ol-P- type 2 precursor type 2 precursor type 2 H blood a (2E)-hex-2-enoyl- hydroxybehenoyl- NADPH-dependent Active β β isopentenyl-diphosphate CDP-ethanolamine phosphocholine -glucuronosyltransferase: B3GAT3 (1->3)-β-D-Gal-(1->3) β-D-GlcNAc-(1->4)-α-D- synthase: (1->3)-[ -D-GlcNAc-(1->2)- α α phospholipase: NAPEPLD [+ 4 isozymes] lysophosphatidylethanolamine ceramide E(C30:0)OdS(C18:0) glyceraldehyde- 3'-monoiodothyronine 3,5,3'-triiodo- microsomal: UGT2B11 microsomal: UGT2B11 galactosylgalactosylxylosylprotein 3- dependent Rib-ol-P-3-β-D- disaccharide 3-L- disaccharide -2,3- group antigen 2- -L- protein] [acp domain within CoA very-long-chain phosphatidylethanolamine biosynthesis II (2E,9Z,12Z,15Z,18Z,21Z) 3'-iodothyronamine breakpoint β β GYS2 α-D-Man-(1->6)]-β-D-Man- arachidonoyl-CoA delta-isomerase: IDI2 3-phosphate galactosylgalactosylxylosylprotein 3- β - -D-Gal-(1->4)- -D- GlcNAc-diphosphodolichol phosphoglycerate UDP-N-acetyl-D- fucosyltransferase: FUT3 sialyltransferase: ST3GAL4 fucosyltransferase: FUT1 reductase: a fatty acid synthase] enoyl-CoA -tetracosahexaenoyl-CoA L-thyronine tetraiodothyroacetate cluster -glucuronosyltransferase: B3GAT3 GalNAc-(1->3) trans-2-enoyl-CoA choline-phosphate thyroxine sulfate β-glucuronosyltransferase: B3GAT2 Xyl]-L-seryl-[protein] GDP-Man:Man(3) a glucosylated (1->4)-β-D-GlcNAc-(1->4)- galactosamine biosynthesis II isopentenyl-diphosphate CBR4 HSD17B8 an N-arachidonoyl-2- dehydrogenase: GAPDH tetraiodothyroacetate mutase: BPGM -β-D-GlcNAc- 4-galactosyl-N- Alpha-2,8-sialyltransferase hydratase: reductase: TECR cytidylyltransferase: anandamide 3-iodothyronamine acyl UDP- region- galactosylgalactosylxylosylprotein 3- glucuronylgalactosylproteoglycan 4- GlcNAc(2)-PP- glycogenin β delta-isomerase: IDI1 vanillyl mandelate -D-GlcNAc}-N-Asn-[protein]alpha-1,6- α HSD17B4 ser 2-acyl-1-alkyl-sn-glycerol lysophosphatidylethanolamine glyceraldehyde- UDP- UDP- sulfotransferase: ether glucuronide glucuronosyltransferase related β-glucuronosyltransferase: B3GAT2 β 3-phospho- (1->4)-O-6-P- acetylglucosaminide 3- -L 8B: ST8SIA2 an H type 2 histo-blood group antigen a (3R)-3- PCYT1A a 3-O-[β-D-GlcA- -N-acetylgalactosaminyltransferase: Dol alpha-1,2- 1,4-α-glucan D-glucopyranose fatty acid biosynthesis glucuronosyltransferase glucuronosyltransferase SULT1A2 α mannosylglycoprotein 6-beta-N- -fucosyltransferase: FUT9 trans-docos- triacontanoyl-CoA ethanolaminephosphotransferase: 3-phosphate 3-iodothyronamine protein β CSGALNACT1 mannosyltransferase: D-glycerate -D-Man]-Ser/ α-D-glucopyranose β-D-galactosyl-1,4-N- DMAPP hydroxyhexanoyl-[acp] a hexanoyl-[acp Choline-phosphate L-thyronine (1->3)- -D-Gal- β branching acetylglucosaminyltransferase (9Z,12Z,15Z,18Z,21Z)- CEPT1 N-arachidonoyl-1-acyl-2- initiation (mitochondria) dehydrogenase: GAPDHS 2B11 precursor, 2B11 precursor, 3,3',5- 3,5,3'-triiodo- tetraiodothyroacetate a 3-O-[ -D-GlcA- Thr-[protein] 2-enoyl-CoA deiodinase: DIO3 (1->3)-β-D-Gal- glucuronylgalactosylproteoglycan 4- ALG11 phosphoglycerate enzyme: GBE1 6-kinase: HK2 type 2 precursor 3-L- acetyl-D-glucosaminyl- type 2 H-antigen N-acetyl-α- H type 2 antigen 3-L- type 2 H-antigen N-acetyl-α- (3R)-3- domain within a 3-oxodotriacontanoyl- tetracosapentaenoyl-CoA cytidylyltransferase lysophosphatidylethanolamine microsomal: UGT2B11 microsomal: UGT2B11 thyronamine (1->3)-β-D-Gal- α-D-Man-(1->2)-α-D-Man- α-dystroglycan β1,4- V: HS14864 2-acyl-1-alkyl-sn-glycerol triiodothyroacetate L-thyronine ester glucuronide β β kinase: PGK2 α fucosyltransferase: FUT6 glycoprotein α-2,3-N- D-galactosaminyltransferase: fucosyltransferase: FUT3 D-galactosaminyltransferase: dimethylallyltransferase: fatty acid synthase] trans- B: PCYT1B acetyl-CoA Type III (1->4)- -D-Xyl]- β -N-acetylgalactosaminyltransferase: α α α xylosyltransferase: α β -D-glucopyranose hydroxyhexanoyl- CoA synthase: ELOVL4 tetracosapentaenoyl- ethanolaminephosphotransferase: phosphodiesterase: ENPP2 sn-glycero-3-phospho-N- 13-DPG sulfotransferase: Tetraspanin-17 (1->3)- -D-Gal- (1->2)- -D-Man-(1->3)-[ -D- GDP- -D-mannose a glycogen -1,6-mannosyl-glycoprotein 6- - acetylneuraminyltransferase: GGPS1 docos-2- iodothyronine 3,5,3'-triiodo-L- 3,5,3'-triiodo-L- L-seryl-[protein] CSGALNACT2 phosphoglycerate 6-kinase: HK3 ABO-B type 2 H blood group 3-α-L ABO [acp] dehydratase: ethanolamine Alpha-1,4-N- (1->4)-β-D-Xyl]- β Man-(1->6)]-β-D-Man-(1->4) RXYLT1 N-acetylglucosaminyltransferase: CoA 6-desaturase: SELENOI CDP-choline (arachidonoyl)ethanolamine thyronine phenol UDP- UDP- UDP- SULT1A1 a 3-O-[ -D-GalNAc- β ST3GAL3 dimethylallyltransferase: enoyl-CoA acetyl-CoA deiodinase: DIO3 thyronine acyl dolichyl-phosphate -D kinase: PGK1 β α a Lewis x epitope -fucosyltransferase: FUT9 HTD2 3-oxodotriacontanoyl-CoA phosphoglycerate acetylglucosaminyltransferase: L-seryl-[protein] -β-D-GlcNAc-(1->4)-α-D- a 3-O-[ -Xyl- MGAT5B -D-glucopyranose FADS2 anandamide sn-glycero-3-phospho-N- glucuronosyltransferase: glucuronosyltransferase glucuronosyltransferase Sulfotransferase glucuronylgalactosylproteoglycan 4- (1->4)-β-D-GlcA- FDPS reductase: ethanolamine carboxylase: ACACA β-D-glucuronide -mannosyltransferase: (1->4)-(Rbo5P) 6-kinase: HK1 a B type 2 histo-blood group antigen an A type 2 histo-blood group antigen a 3-oxooctanoyl- 2-acyl-1-alkyl-sn-glycerol kinase: PGK2 A4GNT β (1->3)-β-D-Gal-(1->3) GlcNAc-diphosphodolichol 13-DPG α-1,6-mannosyl-glycoprotein 6-β- an N-acetyl-α-neuraminyl-(2->3)-β-D- TECR 3-oxodotriacontanoyl- (6Z,9Z,12Z,15Z,18Z,21Z) (arachidonoyl)ethanolamine acetyl-CoA thyronamine UGT1A8 2B11 precursor, 2B11 precursor, 1A1: SULT1A1 Cadherin-4 -N-acetylgalactosaminyltransferase: DPM2 DPM3 DPM1 -3-βGalNAc- a (2E)-hex-2-enoyl-[acp] [acp domain within kinase: ETNK1 cholinephosphotransferase: phosphoglycerate 2 glucose β a Lewis y epitope geranyl diphosphate CoA reductase: -tetracosahexaenoyl-CoA phosphodiesterase: GDE1 microsomal: UGT2B11 microsomal: UGT2B11 Carbohydrate Degradation glucuronyl-galactosyl- CSGALNACT1 -β-D-Gal-(1->4)-β-D- N-acetylglucosaminyltransferase: galactosyl-(1->4)-N-acetyl- -D-glucosaminyl-R [+ 2 isozymes] carboxylase: ACACB gala-series glycosphingolipids biosynthesis (1->3)-βGlucNAc- B type 2 antigen 3-L- A type 2 antigen 3-L- a fatty acid synthase] a plasmanylethanolamine CEPT1 kinase: PGK1 3,5,3'-triiodo-L- proteoglycan 4-α-N- Xyl]-L-seryl-[protein] a dolichyl β-D-mannosyl phosphate glyceraldehyde- β MGAT5β phosphorylase: HKDC1 α(2,3)sialyl-N- docosanoyl-CoA HSD17B12 triiodothyroacetate glucuronylgalactosylproteoglycan 4- chondroitin sulfate 3-β- (1->4)-(P6)- a { -D-GlcNAc-(1->2)-[ -D- fucosyltransferase: FUT3 fucosyltransferase: FUT3 ω (2E)-hex-2- anandamide thyronine phenolic triiodothyronine sulfate β-D-glucopyranose α ,E,E-farnesyl diphosphate O-phosphoethanolamine malonyl-CoA a sphingosine acyl UDP- triiodothyroacetate acetylglucosaminyltransferase: β α-D-Man-(1->2)-α-D-Man- 3-phosphate α GlcNAc-(1->4)]-α-D-Man-(1->3)- CMP-N-acetylneuraminate acetyllactosamine -3- enoyl-[acp] a plasmanylcholine acetyl-CoA 3-phospho-D-glycerate β D-galactose degradation V (Leloir pathway) -N-acetylgalactosaminyltransferase: glucuronosyltransferase: O- Man]-Ser/ synthase: GGPS1 (3R)-3-hydroxydotriacontanoyl-CoA -D-glucuronide trehalose degradation EXTL2 dehydrogenase: β β 6-kinase: GCK biosynthesis I (eukaryotes) fucosyltransferase: FUT6 a B (Lewis y) histo-blood group epitope an A (Lewis y) histo-blood group epitope 2-acyl-1-alkyl-sn-glycero- ceramide glucuronosyltransferase ether glucuronide sucrose degradation hBravo CSGALNACT2 CHPF2 (1->2)-α-D-Man-(1->3)-[α-D- Thr-[protein] [ -D-GlcNAc-(1->2)-[ -D-GlcNAc- reductase: (2E,6Z,9Z,12Z,15Z,18Z,21Z) malonyl CoA-acyl β α-dystroglycan D-glucopyranose 6-phosphate ω,E,E-farnesyl diphosphate a (3R)-3- ethanolamine- (4Z,7Z,10Z,13Z,16Z)-docosa- 2,3-bisphosphoglycerate- glucuronyl-galactosyl- a 3-O-[ -D- β GAPDH (1->6)]-α-D-Man-(1->6)]-β-D- UDP-N-acetyl- α(2,3)sialyl-N- MECR 3-phosphoethanolamine ceramide β-D- β N-acetylgalactosaminyl- Man-(1->6)]- -D-Man-(1->4) xyloside β-1,4- synthase: FDPS hydroxyoctanoyl- enoyl-CoA -tetracosaheptaenoyl-CoA carrier protein -D-galactopyranose α α GalNAc-(1->4)- Man-(1->4)-β-D-GlcNAc-(1->4) α-D-glucosamine α 3-oxolignoceroyl- phosphate desaturase: TMEM189 4,7,10,13,16-pentaenoate galactosyltransferase: dependent triiodothyroacetate sucrose , -trehalose proteoglycan 4-alpha-N- β -β-D-GlcNAc-(1->4)-α-D- β glyceraldehyde- acetyllactosamine -(1,3) hydratase: HSD17B4 transacylase: MCAT β-D-GlcA-(1->3) proteoglycan 3- - a dolichyl -D-mannosyl phosphate glucuronosyltransferase: β Glucose-6-phosphate bifunctional UDP-N- a hexanoyl-[acp] [acp domain within CoA cytidylyltransferase: (2E,6Z,9Z,12Z,15Z,18Z,21Z) biosynthesis II (4-desaturase) phosphoglycerate ester glucuronide Aldose 1- acetylglucosaminyltransferase: GlcNAc-diphosphodolichol 3-phosphate - -D-GlcNAc}-N-Asn-[protein] -fucosyltransferase: FUT5 UGT8 Mib β glucuronosyltransferase: β B4GAT1 β isomerase: GPI acetylglucosamine (2E,6E)-farnesyl diphosphate a fatty acid synthase] PCYT2 -tetracosaheptaenoyl- mutase: PGAM2 epimerase: sucrose α- EXTL3 - -D-Gal-(1->3) dehydrogenase: a 3-O-[ - -N-acetylglucosaminylglycopeptide 3-oxolignoceroyl- trans-dotriaconta-2-enoyl-CoA CDP-diacylglycerol cardenolide biosynthesis arachidonoyl-CoA a β-D-galactosyl-N trehalase: TREH a 3-O-[α-D- β CHSY3 β 2-epimerase/N- mucin core 1 and core 2 O-glycosylation a 1,2-diacyl-sn-glycerol CoA hydratase: EHHADH a plasmenylethanolamine a malonyl-[acp] an acetyl-[acp] glucosidase: SI - -D-Gal-(1->4) dolichyl GAPDHS GlcA(1->4)- -1,4-galactosyltransferase: a sialyl-Lewis x epitope 3-oxooctanoyl- CoA reductase: 3-oxo adrenoyl-CoA -acylsphingosine 2,3-bisphosphoglycerate- GALM triosephosphate F6P CDP-ethanolamine biosynthesis GlcNAc-(1->4)- β β acetylmannosamine enoyl-CoA - -D-Xyl]-L- N-acetylgalactosaminyl- mannosyltransferase: -Xyl-(1->4)- B4GALT1 squalene synthase: FDFT1 [acyl-carrier- HSD17B12 NADPH-dependent synthase: ELOVL2 dependent β ADP- β β D-glyceraldehyde isomerase: TPI1 a {β-D-Gal-(1->4)-β-D-GlcNAc- kinase: GNE sialyl-Lewis x epitope 6- plasmenylethanolamine progesterone Amino Acid Degradation superpathway of L-tryptophan utilization α-D-galactopyranose -D-fructofuranose β α -D-GlcA-(1->3) seryl-[protein]chondroitin sulfate 3- - proteoglycan 3-β- DHAP (Rbo5P) -3- Glucosamine-6-phosphate α a [glycoprotein]-(L- protein] (3R)-3- very-long-chain hydratase: HADHA galactosylceramide α- β-galactosyl-N- phosphoglycerate -D-glucopyranose -D-glucopyranose ribosylation ALG3 3-phosphate 2 N-acetyl- -D- a (2E)-oct-2-enoyl- 1,2-diacyl-sn-glycerol phosphohydrolase DHAP 3-oxo adrenoyl-CoA acetoacetyl-[acyl- superpathway of methionine degradation -β-D-Gal-(1->3) glucuronosyltransferase: β (1->2)-[β-D-Gal-(1->4)-β-D- sulfotransferase: CHST1 serine/L-threonine) glucuronosyltransferase: GalNAc-(1->3)- isomerase 1: GNPDA1 mannosamine synthase: [acp domain within hydroxylignoceroyl- trans-2-enoyl-CoA ethanolaminephosphotransferase: enoyl-CoA carrier-protein] 2,3-sialyltransferase: acylsphingosine mutase: PGAM1 factor 1 -β-D-Gal-(1->4) GlcNAc-(1->4)]-α-D-Man-(1->3)- squalene synthase: ELOVL5 galactokinase: ketohexokinase: KHK CHPF2 CHPF α-D-Man-(1->2)-α-D-Man-(1->2) βGlucNAc-(1->4) Glucosamine-6-phosphate polypeptide N- OXSM a fatty acid synthase] CoA reductase: TECR hydratase: ECHS1 progesterone synthase: OXSM ST3GAL5 sulfotransferase: β β β a 6-sulfo-sialyl Lewis x epitope SELENOI CDP-choline a 2-acyl-1-Z-alk-1-enyl-sn-glycerol 3-oxoadrenoyl-CoA a digalactosylceramide 2,3-bisphosphoglycerate- trp GALK1 Glutamate - -D-Xyl]-L- -α-D-Man-(1->3)-[α-D-Man- -(P6)-O-αMan]- [ -D-Gal-(1->4)- -D-GlcNAc-(1->2) acetylgalactosaminyltransferase: α N-acetylgalactosaminyl- N-acetylgalactosaminyl- protein N-glycosylation processing phase (mammalian) isomerase 2: GNPDA2 squalene enoyl-CoA (3S,6Z,9Z,12Z,15Z,18Z,21Z)-3- sn-glycerol 5 -reductase: GAL3ST1 L-homocysteine seryl-[protein] fructose- α-dystroglycan α1,3- -[β-D-Gal-(1->4)-β-D-GlcNAc- dotriacontanoyl-CoA 1,2-diacyl-sn-glycerol synthase: ELOVL7 dependent β receptor N-acetylglucosaminyl- proteoglycan 3-β- β (1->3)-α-D-Man-(1->6)]-β-D- Ser/Thr-[protein] GALNT1 a 3-oxooctanoyl-[acp] hydratase: hydroxytetracosahexaenoyl-CoA (7Z,10Z,13Z,16Z)-3- α-D-galactose -D-fructofuranose 1-phosphate proteoglycan 3- - bisphosphate α β N-acetyl-D- monooxygenase: SQLE ethanolaminephosphotransferase: 3-phosphate SRD5A2 5β-pregnan- a ganglioside GM4 digalactosylceramide phosphoglycerate UDP-α-D-glucose β β xylosyltransferase: (1->6)]- -D-Man-(1->6)]- -D- α-D-glucosamine 6-phosphate 2-acyl-1-Z-alk-1-enyl-sn-glycerol oxodocosatetraenoyl-CoA an acetoacetyl-[acp] a galactosylceramide D-glucopyranose ionotropic, proteoglycan 4- - glucuronosyltransferase: glucuronosyltransferase: Man-(1->4)- -D-GlcNAc-(1->4)- aldolase: [+ 18 isozymes] EHHADH (3S)-hydroxy- progesterone 3,20 dione sulfotransferase: mutase: BPGM tryptophan 5- L-tryptophan tryptophan 2,3- S-methylmethionine betaine-- 1-phosphate Glc Man GlcNAc -[protein] β mannosamine an octanoyl-[acp 3-oxotetratriacontanoyl- CEPT1 glycerol 3- methionine α LARGE2 3 9 2 Man-(1->4)- -D-GlcNAc-(1->4) cholinephosphotransferase: delta-2 glucuronosyltransferase: CHSY3 -D-GlcNAc-diphosphodolichol (3S)-2,3-epoxy-2,3-dihydrosqualene 3-oxooctanoyl- 3-oxodocosatetraenoyl- sulfate GAL3ST1 decarboxylase: dioxygenase: homocysteine homocysteine S- α a 3-O-[β-D-GlcA-CHSY1 dolichyl-P-Man:Man ALDOC β β-D-galactosyl-1,3-N- domain within a enoyl-CoA CoA synthase: ELOVL4 (6Z,9Z,12Z,15Z,18Z,21Z) phosphate 5α-reductase: hydroxylase: synthase: fructose-1-phosphate -D-glucopyranose EXT2 EXT1 6 α-dystroglycan α1,3- - -D-GlcNAc}-N-Asn-[protein] N-acetylmannosamine a Tn antigen [acyl-carrier CEPT1 CoA reductase: a 3-O-[β-D-GlcA- N-acetylgalactosaminyl- β GlcNAc -PP- mannosyl- hydratase: -tetracosahexaenoyl-CoA SRD5A1 a digalactosylceramide 2-phospho-D-glycerate TPH1 DDC TDO2 methyltransferase: methyltransferase: aldolase: ALDOB 6-kinase: HK2 (1->3)- -D-GalNAc- 2 fructose- acetyl-D-galatosaminyl- kinase: GNE fatty acid synthase] acyltransferase: MTR Protocadherin α β α xylosyltransferase: oligosaccharide α- protein] HADHA a phosphatidylethanolamine HSD17B12 sulfate BHMT2 BHMT α (1->3)- -D- proteoglycan 3- - (1->4)-β-D-GlcA- dolichol -1,2- bisphosphate a 3-O-[α- glycoprotein α-2,3-N- glycoprotein-N- lanosterol synthase: LSS 3-oxotetratriacontanoyl-CoA dehydrogenase: EHHADH GPAM tryptophan 5- tryptophan 2,3- fructose bisphosphate -D-glucopyranose LARGE1 N-acetyl-D- reductase: phosphoglycerate beta-5 GlcNAc-(1->4)- glucuronosyltransferase: β mannosyltransferase: β 1,2-glucosidase: D-glucosamine 6-phosphate acetylgalactosamine 3- a plasmenylcholine 5α-pregnane- (3R,7Z,10Z,13Z,16Z)-3- dioxygenase: 6-kinase: HK3 (1->3)- -D-Gal-(1->3) aldolase: Xyl-(1->3)- - acetylneuraminyltransferase: mannosamine CBR4 enoyl-CoA (3S)-3-hydroxyacyl-CoA [+ 3 isozymes] enolase: ENO1 hydroxylase: tryptamine aldolase: ALDOA β MOGS 3-oxotetratriacontanoyl- hydroxydocosatetraenoyl-CoA met -D-GlcA-(1->3) CHPF -β-D-Gal-(1->4)-β-D- ALG9 GlcA(1->4)- a {β-D-Gal-(1->4)-β-D-GlcNAc-ST3GAL3 β-galactosyltransferase: hydratase: dehydrogenase: HADH 3,20-dione TPH2 IDO2 α-D-glucopyranose α-D-Man-(1->2)-α-D-Man- ALDOA 6-phosphate lanosterol HSD17B8 a 3-oxodecanoyl- CoA reductase: cardiolipin biosynthesis phosphoglycerate fructose-bisphosphate -β-D-Gal-(1->3) β (1->2)-[β-D-Gal-(1->4)-β-D- Glucosamine 6-phosphate C1GALT1 a 2-lysophosphatidate α tryptamine N-acetylgalactosaminyl- Xyl]-L-seryl-[protein]glucuronosyl-N-acetylgalactosaminyl- (1->2)-α-D-Man-(1->3)-[α-D- -Xyl-(1->4)- Glc Man GlcNAc -[protein] N-acetylneuraminate ECHS1 (3S)-3-hydroxyacyl-CoA 3 -hydroxysteroid enoyl-CoA indoleamine 2,3- aldolase: ALDOC 6-kinase: HK1 β fructose- 2 9 2 α N-acetyltransferase: [acp domain within HSD17B12 enolase: ENO2 S-adenosylmethionine CD158z - -D-Gal-(1->4) proteoglycan 3-β- β (Rbo5P) -3- GlcNAc-(1->4)]- -D-Man- 9-phosphate a (3R)-3- enoyl-CoA dehydrogenase: HADH dehydrogenase: hydratase: HSD17B4 deaminase: dioxygenase: β-D-glucopyranose proteoglycan 4- -N- Man-(1->2)-α-D-Man-(1->3) bisphosphate 2 core 1 a fatty acid synthase] phosphatidylserine biosynthesis II 5-hydroxy- synthase: -β-D-Xyl]-L- β (1->3)-[α-D-Sial-(2->3)-β-D- GNPNAT1 lanosterol,NADPH:oxygen 24,25- hydroxyoctanoyl-[acp] 1-acyl-sn-glycero- a CDP-diacylglycerol phosphoglycerate MAOB glucuronosyltransferase: GalNAc-(1->3)- Glc Man synthase: NANS hydratase: (3R)-3-hydroxytetratriacontanoyl-CoA AKR1C2 IDO1 6-kinase: GCK acetylgalactosaminyltransferase: -α-D-Man-(1->6)]-β-D-Man- aldolase: 2 9 3-hydroxyacyl-CoA (2E,7Z,10Z,13Z,16Z)- L-tryptophan MAT2B MAT2A D-glyceraldehyde DHAP seryl-[protein]N-acetylglucosaminyl- β β GlcNAc α-1,3- Gal-(1->4)-β-D-GlcNAc-(1->2) glucosamine-phosphate N-acetyl-β- oxidoreductase: CYP51A1 dihydrolanosterol:NADP+ 3-phosphate CDP-diacylglycerol-- enolase: ENO3 a 3-O-[ -D-GlcA-CHSY1 CHSY3 β α GlucNAc-(1->4) 2 (3R)-3- HSD17B4 dehydrogenase: HADHA 3α-hydroxysteroid (indol-3-yl) Adherens proteoglycan 4-β- (1->4)- -D-GlcNAc-(1->4)- - ALDOB ∆ 24 docosapentaenoyl-CoA β α glucosidase: -[β-D-Gal-(1->4)-β-D-GlcNAc- N-acetyltransferase neuraminate CMP-N- core 2 β-1,6-N- -oxidoreductase: DHCR24 a phosphatidylethanolamine acyltransferase: glycerol-3-phosphate 3- 5-hydroxy-L- S-adenosylmethionine D-glucopyranose 6-phosphate (1->3)- -D- D-GlcNAc-diphosphodolichol -(P6)-O- Man]-α β hydroxyoctanoyl- trans-lignocer- enoyl-CoA dehydrogenase: phosphoenolpyruvate acetaldehyde N-Formyl-L- junction- glucuronosyltransferase: glucuronosyl-N-acetylgalactosaminyl- -dystroglycan 1,3- 3-hydroxyacyl-CoA AGPAT1 synthetase: MAT1A GalNAc-(1->4)- Dol-P-Man:Man(7) Ser/Thr-[protein] PRKCSH GANAB (1->6)]-α-D-Man-(1->6)]-β-D- 1: GNPNAT1 9-phosphate acetylneuraminate- acetylglucosaminyltransferase: a (3R)-3- hydratase: HSD17B4 L-serine- phosphatidylserine phosphatidyltransferase: tryptophan glyceraldehyde triosephosphate associated EXTL1 proteoglycan 4-β-N- glucuronosyltransferase: 30-hydroxylanosterol [acp] dehydratase: 2-enoyl-CoA dehydrogenase: AKR1C1 kynurenine β GlcNAc(2)-PP- Man-(1->4)-β-D-GlcNAc-(1->4) N-acetylneuraminate- beta-galactosamide- GCNT3 hydroxydecanoyl- phosphatidylethanolamine biosynthesis I [+ 11 isozymes] PGS1 pyruvate kinase: PKLR decarboxylase: alcohol kinase: TKFC isomerase: TPI1 protein 1 -D-GlcA-(1->3) β-D-fructose 1,6- N-acetyl-D-glucosamine 6-phosphate 24,25-dihydrolanosterol HTD2 HSD17B10 5α-dihydroprogesterone indole kynurenine acetylgalactosaminyltransferase: Dol alpha-1,6- LARGE2 GlcMan GlcNAc -[protein] β [acp domain within trans- phosphatidyltransferase: SAM glucuronosyl-N-acetylglucosaminyl- β 9 2 - -D-GlcNAc}-N-Asn-[protein] 9-phosphate alpha-2,3- β α trans-tetratriaconta-2-enoyl-CoA a phosphatidylglycerophosphate a [pyruvate dehydrogenase pyruvate kinase: PKM DDC dehydrogenase: - -D-Gal-(1->3) bisphosphate -1,3-galactosyl-O-glycosyl- 4,4-dimethyl-14 - a phosphatidate reductase: AKR1C3 superpathway of glycosphingolipids biosynthesis acetaldehyde formamidase: Galactose-1- UDP- α CHPF mannosyltransferase: α-dystroglycan β1,4- β-galactoside α-2,6- a fatty acid synthase] lignocer-2- PTDSS2 (6Z,9Z,12Z,15Z,18Z,21Z)-3- a phosphatidylcholine adrenoyl-CoA 6 Actin- proteoglycan 4- -N- -β-D-Gal-(1->4) phosphatase: NANP sialyltransferase: glycoprotein β-1,6-N- hydroxymethyl-5α- 24,25- a (2E)-oct-2-enoyl-[acp] E2 protein] N -lipoyl-L-lysine dehydrogenase: AKR1A1 α α fructose-1,6- phosphoacetylglucosamine enoyl-CoA a phosphatidylserine oxotetracosahexaenoyl-CoA phosphatidylcholine 3α-hydroxysteroid serotonin AFMID phosphate galactose 4- acetylglucosaminyltransferase: -β-D-Xyl]-L- glucuronosyl-N-acetylgalactosaminyl- -D-Man-a-(1->2)- ALG12-D-Man- glucoronosyltransferase: Glc Man sialyltransferase: N-acetyl-β- ST3GAL2 acetylglucosaminyltransferase: cholesta-8,24-dien- dihydrolanosterol,NADPH:oxygen NADPH-dependent phosphatidate phosphatidylglycerophosphatase: pyruvate associated α a 3-O-[β-GlcA- 1 9 mutase: PGM3 a sphingosine ALDH3A2 aceta a 3-O-[ -D- α α bisphosphatase: reductase: - serine O- dehydrogenase: adrenoyl-CoA 4- uridylyltransferase: epimerase: EXT2 EXT1 seryl-[protein] glucuronosyl-N-acetylgalactosaminyl- proteoglycan 4-β-N- (1->2)- -D-Man-(1->3)-[ -D- LARGE1 GlcNAc α-1,3- ST6GAL1 neuraminate GCNT1 3β-o,NADPH:oxygen oxidoreductase: CYP51A1 (2E)-oct-2- very-long-chain cytidylyltransferase: PTPMT1 D-glyceraldehyde 3-phosphate protein (1->3)-α- 2 CMP-N- ceramide aldehyde L-kynurenine GlcNAc-(1->4)- α α FBP1 glycoprotein a {α-D-Sial-(2->6)-β-D-Gal-(1->4) TECR trans-2-enoyl-CoA phosphatidyltransferase: AKR1C4 desaturase: FADS2 (indol-3-yl)ethanol GALT GALE proteoglycan 4-β-N- acetylgalactosaminyltransferase: Man-(1->2)- -D-Man-(1->3)-[ - β glucosidase: N-acetyl-α-D-glucosamine 1-phosphate N-acylneuraminate oxidoreductasel: CYP51A1 α enoyl-[acp] CDS1 serotonin N- serotonin serotonin α-D-glucopyranose FAM107A β Xyl-(1->3)- - α β β acetylneuraminate- [+ 2 isozymes] 4,4-dimethyl-14 -hydroxymethyl- a (2E)-dec-2-enoyl- ceramide dehydrogenase: α -D-GlcA-(1->3) acetylgalactosaminyltransferase: CHSY1 D-Man-(1->6)]-α-D-Man-(1->6)]-β- fructose-1,6- PRKCSH GANAB endo- -1,2- - -D-GlcNAc-(1->2)-[ -D-Gal- reductase: TECR PTDSS1 3β-hydroxy-5α- (4Z,7Z,10Z,13Z,16Z)- a phosphatidylglycerol SAH UDP- -D-galactose α GlcA(1->4)- cytidylyltransferase: β-galactosamide-α- 5α-cholesta-8-en-3β-ol reductase: [acp domain within lignoceroyl-CoA (4Z,7Z,10Z,13Z,16Z,19Z) phosphatidate glucosyltransferase: pyruvate dehydrogenase: acetyltransferase: oxidase: sulfotransferase: ALDH3B1 kynurenine 3- 1-phosphate - -D-GlcNAc- CHSY3 D-Man-(1->4)-β-D-GlcNAc-(1->4) UDP-α-D-glucose bisphosphatase: mannosidase: (1->4)-β-D-GlcNAc-(1->4)]-α-D- UDP-N-acetylglucosamine 30-oxolanosterol a phosphatidylserine pregnane-20-one docosapentaenoyl-CoA glucuronylgalactosylproteoglycan 4- β-Xyl-(1->4)- Man GlcNAc 1,2- CMAS 2,3-sialyltransferase: α MECR a fatty acid synthase] tetratriacontanoyl-CoA -docosahexaenoyl-CoA cytidylyltransferase: PDHB PDHA2 AANAT MAOA SULT1A3 monooxygenase: (1->4)-β-D-GlcA- -α-D-GlcNAc-diphosphodolichol FBP2 Man GlcNAc -[protein] 9 2 MANEA Man-(1->3)-[α-D-Sial-(2->3)-β- core 2 4,4-dimethyl-14 - bile acid biosynthesis, neutral pathway UGCG cardiolipin CD312 β dolichyl-P-Man:Man 9 2 α pyrophosphorylase: phosphoglucomutase: glucuronosyl-N-acetylgalactosaminyl- -N-acetylgalactosaminyltransferase: 8 Dolichyl- (Rbo5P) -3- -mannosidase: CMP-N-acetyl- ST3GAL1 α α 3-oxocerotoyl- CDS2 pyruvate dehydrogenase: KMO (1->3)-β-D-Gal- 2 β 4,4-dimethyl-14 -formyl- hydroxymethyl-5 -cholesta- a β-D-glucosyl-N (isomer 9A B ) D-Gal-(1->4)- -D-GlcNAc-(1->2) synthetase: CRLS1 adenosylhomocysteinase: proteoglycan 4-β-N- CSGALNACT2 GlcNAc -PP- β 1,2,3 1,2,3 HS02988 β-neuraminate β an octanoyl-[acp] CoA 5-hydroxyindole serotonin (indol-3-yl)acetate PGM2 β 2 phosphate beta- F6P GalNAc-(1->3)- MAN1C1 -1,3-galactosyl-O-glycosyl- 5α-cholesta-8,24-dien- 8-en-3β-ol,NADPH:oxygen 3-oxohexatriacontanoyl- a CDP- PDHB PDHA1 (1->3)- -D-Gal- α -[β-D-Gal-(1->4)-β-D-GlcNAc- -acylsphingosine N-acetyl-serotonin 3-hydroxy- AHCY ace acetylgalactosaminyltransferase: dolichol -1,2- β UDP-N-acetylglucosamine α [glycoprotein] β-1,3-N- synthase: cholesterol acetaldehyde O-sulfate phosphoglucomutase: β glucuronylgalactosylproteoglycan 4- glucosyltransferase: GlucNAc-(1->4) α β an N-acetyl- - 3β-ol,NADPH:oxygen oxidoreductase: CYP51A1 CoA synthase: ELOVL4 diacylglycerol β Ptd Gro (1->4)- -D-Xyl]- endoplasmic (1->6)]- -D-Man-(1->6)]- -D- a decanoyl-[acp glucosylceramide -1,4- 2 L-kynurenine Protocadherin CHPF mannosyltransferase: Man GlcNAc -[protein] pyrophosphorylase: UAP1 3-oxodecanoyl- ELOVL1 a [glycerolipid]-(4Z,7Z,10Z,13Z,16Z,19Z) PGM1 β-N-acetylgalactosaminyltransferase: ALG5 Glucose-6- -(P6)-O-αMan]- 8 2 neuraminyl-(2->3) acetylglucosaminyltransferase: hydroxyindole O- L-seryl-[protein] reticulum Man-(1->4)-β-D-GlcNAc-(1->4) oxidoreductase (14- domain within a cholesterol 7α- galactosyltransferase: dihydrolipoyl alpha-5 ALG9 (isomer 8A B ) 4,4-dimethyl-14α-formyl-5α-cholesta-8-en-3β-ol [acyl-carrier- 3-oxohexatriacontanoyl-CoA -docosahexaenoate alcohol ser β CSGALNACT1 α-D-Man-(1->2)-α-D-Man- phosphate Ser/Thr-[protein] 1,2,3 1,2 α -β-D-galactosyl- B3GNT3 3-oxocerotoyl- methyltransferase: 5-hydroxyindole kynureninase: glucuronosyl-N-acetylgalactosaminyl- a 3-O-[ -D-GalNAc- mannosyl- Man GlcNAc -[protein] -β-D-GlcNAc}-N-Asn-[protein] UDP-N-acetyl- -D-glucosamine methyl cleaving): CYP51A1 fatty acid synthase] monooxygenase: B4GALT6 dehydrogenase: DLD L-homocysteine D-glucopyranose a dolichyl β-D-glucosyl phosphate 8 2 protein] dehydrogenase: proteoglycan 4-β-N- (1->4)-β-D-GlcA- (1->2)-α-D-Man-(1->3)-[α-D- isomerase: (1->3)-N-acetyl-α- O-3-{N-acetyl-β-D- CoA ASMT acetaldehyde KYNU 6-phosphate oligosaccharide (isomer 8A B ) UDP-N-acetylglucosamine 4,4-dimethyl-14α-formyl- synthase: 3-oxohexatriacontanoyl- CYP7A1 POR NADH repair α α GPI 1,2,3 2,3 α β a lactosylceramide ADH6 dehydrogenase: 5-hydroxyindole acetylgalactosaminyltransferase: (1->3)-β-D-GalNAc- Man-(1->2)- -D-Man-(1->3)-[ - α D-galactosaminyl- glucosaminyl-(1->3) 4,4-dimethyl-5- -cholesta-8,14,24-trien-3- -ol 3-oxocerotoyl- CoA reductase: a [pyruvate dehydrogenase E2 a [pyruvate dehydrogenase E2 protein] Detoxification arsenic detoxification (mammals heparosan- 1,2- - 4-epimerase: GALE 5α-cholesta-8-en-3β- OXSM melatonin thiazolidine 4.1B β D-Man-(1->2)-α-D-Man-(1->6) D-glucopyranose [glycoprotein] β α 6 6 ALDH2 3-hydroxyanthranilate β CHSY1 (1->4)- -D-GlcA- - -D-galactosyl- CoA 7 -hydroxycholesterol 5-hydroxyindole cystathionine - glycan moiety of mannosidase: 4,4-dimethyl-5α-cholesta- ol,NADPH:oxygen HSD17B12 protein] N -dihydrolipoyl-L-lysine N -S-acetyldihydrolipoyl-L-lysine NADH [core protein] β ]-α-D-Man-(1->6)]-β-D-Man- 6-phosphate Man GlcNAc Man GlcNAc UDP-N-acetyl-α-D-galactosamine (1->3)-[N-acetyl- a 3-oxododecanoyl- acetaldehyde carboxylate glucuronylgalactosylproteoglycan 4- (1->3)- -D-Gal-(1->3) 8 2 8 2 reductase: lactosylceramide lactosylceramide β-1,4 N- α lactosylceramide 5-hydroxyindole synthase: CBS α-dystroglycan MAN1B1 8,24-dien-3β-ol:NADP+ oxidoreductase: CYP51A1 a 3-oxodecanoyl-[acp] [acp domain within lactosylceramide lactosylceramide 4- - 3-hydroxyanthranilate arsenate β -β-D-Gal-(1->4)-β-D- (1->4)-β-D-GlcNAc-(1->4)-α- isomer 8A Man GlcNAc isomer 8A β-D-glucosaminyl- HSD17B12 (3R)-3-hydroxyhexatriacontanoyl-CoA 3 beta- cytochrome cytochrome melatonin reductase: acetaldehyde -N-acetylgalactosaminyltransferase: a dolichyl β-D-glucosyl phosphate glucose-6- 1,2,3 8 2 1,2,3 ∆ α-2,6- α-2,3- acetylgalactosaminyltransferase: galactosyltransferase: 1,3-N-acetyl-β-D- α-dystroglycan α1,3- 14-oxidoreductase: LBR a fatty acid synthase] hydroxysteroid 3,4-dioxygenase: HAAO Xyl]-L-seryl-[protein] D-GlcNAc-diphosphodolichol B 1,2-α- isomer 8A B 1,2-α- (1->6)]-N-acetyl-α- 4,4-dimethyl-5-α-cholesta-8,14-dien-3-β-ol (3R)-3- NADH P450 2A6: P450 2A6: myeloperoxidase ADH1B dehydrogenase: CSGALNACT2 phosphatase: Man GlcNAc -[protein] 2,3 1,2,3 1,2 3-oxodecanoyl- sialyltransferase: sialyltransferase: B4GALNT1 A4GALT glucosaminyltransferase: sodium-dependent CPO β 8 2 2-amino-3- xylosyltransferase/ 1,3- mannosidase: B 1,2-α- mannosidase: D-galactosaminyl}-L- Delta(14)-sterol hydroxycerotoyl- enoyl-CoA dehydrogenase hydratase: CYP2A6 CYP2A6 ALDH3A2 L-cystathionine glucuronylgalactosylproteoglycan 4- G6PC2 (isomer 8A B ) 1,2 [acyl-carrier ST6GAL1 ST3GAL5 B3GNT5 phosphate transporter a [heparan- a [heparan glucuronosyltransferase: 1,2,3 1,3 reductase: TM7SF2 4,4-dimethyl-5α-cholesta- type 7: HSD3B7 NADH 5-methoxytryptamine 1 2 carboxymuconate- β Dolichyl MAN1A2 mannosidase: MAN1C1 seryl/threonyl-[protein] CoA hydratase: HSD17B4 GAPDH melatonin O- melatonin 6- N -acetyl-N -formyl- 2: SLC20A2 sulfate]-β-D- sulfate]-N-acetyl- -N-acetylgalactosaminyltransferase: glucose-6- LARGE2 terminal O-glycans residues modification (via type 2 precursor disaccharide) β ∆ protein] a ganglioside GA2 a globotriosylceramide hydratase: 5-hydroxytryptophol 6-semialdehyde β pyrophosphate MAN1C1 8-en-3- -ol:NADP+ 14- enoyl-CoA α a 3-O-[ -D- Man GlcNAc Man GlcNAc a (3R)-3- 7 -hydroxycholest- an N-acetyl-α- demethylase: hydroxylase: 5-methoxykynuramine 5-hydroxyindole α CSGALNACT1 a 3-O-chondroitin- phosphatase: 8 2 8 2 14-demethyllanosterol reductase: NADHX amine cystathionine sodium-dependent glucuronate -D-glucosamine Man9GlcNAc2 α α oxidoreductase: LBR hydratase: trans-hexatriaconta-2-enoyl-CoA 4-en-3-one a ganglioside GM3 a lactotriaosylceramide dihydrolipoyllysine-residue GAPDH VAV-3 GalNAc-(1->4)- G6PC3 -dystroglycan 1,3- isomer 8A isomer 8A Man GlcNAc an N-acetyl-β-D- CBR4 hydroxydodecanoyl- neuraminyl-(2->6) ganglioside GA2 β-1,3- globotriaosylceramide 3-β-N- POR CYP2C19 CYP1B1 acetate heparosan- heparan L-seryl-[protein] 1,2,3 1,2,3 8 2 acetyltransferase: DLAT epimerase: (R)-NADHX oxidase: 2-amino 3- γ-lyase: CTH phosphate transporter β alpha-1,3- xylosyltransferase/β1,4- Delta(14)-sterol [acp domain within HSD17B4 β acetyl-CoA Sulfotransferase UDP- -D-GlcA-(1->3) B 1,2-α- B 1,2-α- isomer 8A glucosaminyl-R 4,4-dimethylzymosterol,NAD(P) HSD17B8 NADPH-dependent - -galactosyl- galactosyltransferase: acetylgalactosaminyltransferase: NAXE [+ 3 isozymes] melatonin 6- MAOA 1: SLC20A1 N-sulfate- sulfate N- glucosyltransferase: glucose-6- 1,3 1,3 1,2,3 β carboxymuconate -β-D-GalNAc- glucoronosyltransferase: mannosidase: mannosidase: B 1,2-α- Man GlcNAc -[protein] β H:oxygen oxidoreductase reductase: TM7SF2 a fatty acid synthase] trans-cerot- 7-alpha- 3-oxo-5-beta- (1->4)-β-D- ganglioside GM3 -1,4 N- ganglioside B3GALT4 B3GALNT1 lactotriaosylceramide lactotriaosylceramide 1A1: SULT1A1 glucuronosyltransferase phosphatase: 1,2 7 2 -N-acetylglucosaminylglycopeptide very-long-chain oxaloacetate hydroxylase: N-acetyl-5- 6-semialdehyde (2Z)-2-aminobut- sodium-dependent glucuronate deacetylase: β ALG6 LARGE1 a (3R)-3- steroid 4- acetylgalactosaminyltransferase: α β-1,3- β-1,4- 5-methoxyindoleacetaldehyde 2B11 precursor, (1->4)- -D-GlcA- MAN1A2 MAN1C1 mannosidase: (isomer 7A B ) β-1,4-galactosyltransferase: (hydroxylating): MSMO1 2-enoyl-CoA trans-2-enoyl-CoA hydroxycholest- glucosyl-(1<-->1) GM3 -2,8- CYP1A2 5-hydroxytryptophol quinolinate cys 5-epimerase: NDST1 G6PC 1,2 1,2 4,4-dimethyl-5α-cholesta-8-en-3β-ol hydroxydecanoyl-[acp] a ganglioside GA1 a globotetraosylceramide (S)-NADHX N-acetyl-serotonin methoxykynurenamine decarboxylase: 2-enoate L-tryptophan degradation XI (mammalian, via kynurenine) phosphate transporter 4.1R (1->3)-β-D-Gal- glycan moiety of MAN1A2 4α-hydroxymethyl-4β-methyl- trans- 4-en-3-one dehydrogenase: -ceramide B4GALNT1 sialyltransferase: galactosyltransferase: galactosyltransferase: sulfotransferase: microsomal: UGT2B11 GLCE a [chondroitin] α α Man GlcNAc Man GlcNAc B4GALT1 reductase: TECR citrate synthase: CS [+ 3 isozymes] ACMSD 2B: SLC34A2 heparan β -D-Glc-(1->3)- -D-Man-(1->2)- α 8 2 8 2 AKR1D1 B3GALT5 B4GALT1 nicotinate-nucleotide (1->3)- -D-Gal- D-glucopyranose -dystroglycan 5α-cholesta-8,24-dien-3β-ol 4,4-dimethyl-5α-cholest- (3R)-3- a (2E)-dodec-2-enoyl- cerot-2- 12-alpha- ST8SIA1 ganglioside SULT1A2 cysteine containing N-acetyl- α-D-Man-(1->2)-α-D-Man-(1->3) isomer 8A isomer 8A β-N-acetylglucosaminylglycopeptide ATP- a [heparan sulfate]- sulfate N- (1->4)-β-D-Xyl]- 1,2,3 1,2,3 α β β hydroxydecanoyl- enoyl-CoA hexatriacontanoyl-CoA hydroxylase: a ganglioside GM2 α globoside α-1,3-N- globotetraosylceramide β- UDP- lactotriaosylceramide 5-hydroxytryptophol pyrophosphorylase: dioxygenase: galactosamine α α B 1,2-α- B 1,2-α- β-1,4-galactosyltransferase: 4 -hydroxymethyl-4 - 8-en-3- -ol,NAD(P) [acp domain within GA1 -2,3- dependent Sulfotransferase UDP- (2Z,4E)-2-amino- trp arsenate α-L-iduronate deacetylase: L-seryl-[protein] -[ -D-Man-(1->2)- -D-Man- 1,3 1,3 CYP8B1 7α-hydroxy-5β- acetylgalactosaminyltransferase: 1,3-galactosyltransferase: β β 6-hydroxymelatonin glucuronide QPRT TREM-2 methyl-5α-cholesta- H:oxygen oxidoreductase [acp] dehydratase: a fatty acid synthase] reductase: a ganglioside GD3 sialyltransferase: galactose:lactotriaosylceramide - -1,4- malate NAD(P)H- 1A1: SULT1A1 glucuronosyltransferase 5-hydroxytryptophol 6-oxohexa- CDO1 NDST2 (1->3)-[α-D-Man-(1->2)-α-D- mannosidase: mannosidase: Man GlcNAc B4GALT3 ganglioside GM2 β-1,3- 5-methoxyindole 2-iminobutanoate [heparan sulfate]- 7 2 HTD2 cholestan-3-one GBGT1 B3GALT5 1,3-galactosyltransferase: B3GALT1 galactosyltransferase: dehydrogenase: MDH1 sulfate MAN1A1 MAN1A2 8,24-dien-3β-ol:oxygen (hydroxylating): MSMO1 TECR ST3GAL2 hydrate N-acetyl-serotonin 2B11 precursor, 5-methoxytryptophol 2,4-dienoate NaMN tryptophan 2,3- Man-(1->6)]-α-D-Man-(1->6)]-β- isomer 7A β-N-acetylglucosaminylglycopeptide galactosyltransferase: Sulfotransferase acetate α 1,2 α α 3-sulfino-L-alanine purine -L-iduronate-2-O heparan GDP-glucose Man GlcNAc -[protein] oxidoreductase 4α-hydroxymethyl-4β-methyl- 7 ,12 -dihydroxycholest- β a ganglioside B4GALT3 malate dehydratase: sulfotransferase: microsomal: UGT2B11 aminomuconate- dioxygenase: D-Man-(1->4)-β-D-GlcNAc-(1->4) 7 2 B 1,2-α- β-1,4-galactosyltransferase: B3GALT4 ganglioside GD3 -1,4 N- ganglioside Forssman 1A1: SULT1A1 Immunoglobulin -sulfotransferase: UDP-N-acetyl-D- Man GlcNAc 1,2 a (2E)-dec-2-enoyl-[acp] cerotoyl-CoA 4-en-3-one ribonucleoside:arsenate sulfate N- biosynthesis II Man GlcNAc -[protein] 8 2 (isomer 7A B ) (hydroxylating): MSMO1 5α-cholesta-8-en-3β-ol α GM1b SSEA-3 lactotriaosylceramide dehydrogenase: MDH2 NAXD SULT1A2 semialdehyde nicotinamide TDO2 a 3-O-chondroitin- -α-D-GlcNAc-diphosphodolicholProbable dolichyl 7 2 isomer 8A 1,2,3 2 mannosidase: B4GALT2 a dodecanoyl-[acp arachidonate a ganglioside acetylgalactosaminyltransferase: GD3 -2,8- globoside a lactotetraosylceramide (S)-malate citrate 6-hydroxymelatonin kappa HS2ST1 deacetylase: glucosamine biosynthesis II 1,2,3 N-acetyl- cysteine alpha-D- (isomer 7A B ) α β α α β 3-oxo-5-beta- β-1,4- [+ 3 isozymes] dehydrogenase: mononucleotide L-seryl-[protein] pyrophosphate 1,2,3 3 B 1,2-α- MAN1C1 a type 2 histo-blood 4 -formyl-4 -methyl-5 - 4 -hydroxymethyl-4 - domain within a biosynthesis IV GM1a B4GALNT1 sialyltransferase: ganglioside sulfotransferase: tryptophan 2,3- variable 3-15 a [heparan- NDST3 D-glucopyranose 1,3 Man GlcNAc (2E)-dec-2- 5β-cholestane-3α,7α-diol NADH serotonin sulfinate ribosyltransferase: PNP 7 2 β steroid 4- α adenylyltransferase: D-glucopyranose α cholesta-8,24-dien-3 -ol methyl-5α-cholesta-8,-en-3β- fatty acid synthase] ST8SIA1 GM1b -2,8- SSEA-3 α-2,3- SSEA-3 α-2- galactosyltransferase: N-acetyl- SULT1A2 ALDH8A1 dioxygenase: sulfate]-2-O-sulfo- Glc1Man9GlcNAc2 -D- mannosidase: isomer 7A group antigen enoyl-[acp] (8-detaturase) dehydrogenase: ganglioside lactotetraosylceramide lactotetraosylceramide glucuronide 2-oxobutanoate ammonium transaminase: heparan α-D-glucopyranose 1,2,3 α β ol:oxygen oxidoreductase sialyltransferase: sialyltransferase: fucosyltransferase: B4GALT4 serotonin sulfate (2Z,4E)-2- NMNAT1 IDO2 Transient α-L-iduronate alpha-1,3- glucopyranose Man GlcNAc MAN1A1 α precursor disaccharide 4 -formyl-4 -methyl- reductase: sterol 26- α a ganglioside GD2 α α GOT1 sulfate N- 7 2 B 1,2- - linoleoyl-CoA AKR1D1 GM1 -2,3- -2-fucosyltransferase: -2,3-sialyltransferase: ribose-1-arsenate 6-kinase: HK2 2 5α-cholesta-8,24-dien- (hydroxylating): MSMO1 hydroxylase: ST8SIA1 ST3GAL2 FUT2 6-sulfatoxymelatonin aminomuconate nicotinamide 2-oxobutanoate indoleamine 2,3- receptor a β-D-glucuronate glucosyltransferase: 6-kinase: HK2 isomer 7A mannosidase: MECR arachidonate sialyltransferase: a ganglioside GT3 FUT2 ST3GAL5 deacetylase: 1,2,3 (11Z,14Z)-3- 7α,12α-dihydroxy- β potential [chondroitin]-N- α-D-Glc-(1->3)-α-D-Glc-(1->3)ALG8 α-D-glucopyranose Man GlcNAc -protein 4-beta- type 2 precursor type 2 precursor type 2 precursor 3β-ol,NAD(P)H:oxygen biosynthesis III (6- CYP27A1 ganglioside GD2 -1,3- a ganglioside SSEA-3 2-α-L- a neolactotetraosylceramide citrate dehydratase: ACO2 mononucleotide dehydrogenase: 3-sulfinopyruvate dioxygenase: in [chondroitin] α-D- B 1,2-α- 7 2 MAN1C1 ST3GAL2 NDST4 chondroitin 6- 3 4α-formyl-4β-methyl-5α-cholesta-8-en-3β-ol a decanoyl-[acyl- oxoicosadienoyl- 5β-cholestan-3-one β cation acetylgalactosamine -α-D-Man-(1->2)-α-D-Man- 6-kinase: HK3 (isomer 7A B ) galactosyltransferase: disaccharide α-2,3- disaccharide β-1,3- disacchride α-2,6- oxidoreductase a 3-oxotetradecanoyl- desaturase, mammals) β galactosyltransferase: ganglioside GT3 -1,4 N- GD1c fucosyltransferase: 2 α adenylyltransferase: BCKDHB IDO1 chondroitin- glucopyranose mannosidase: 1,2,3 1 (25R)-5 -cholestane- α SSEA-4 a III - - a ganglioside fumarate hydratase: FH 4-O-sulfotransferase: sulfotransferase: α α Man GlcNAc carrier protein] laurate CoA synthase: ganglioside GM1a -2,3-N- B3GALT4 acetylgalactosaminyltransferase: NMNAT2 kynureninase: channel a [heparan sulfate]- (1->2)- -D-Man-(1->3)-[ -D- α 7 2 GTA sialyltransferase: galactosyltransferase: sialyltransferase: (hydroxylating: MSMO1 α β α [acp domain within α α FUT1 3'-isoLM1 L-isoleucine degradation BCKDHA DBT DLD glucuronate CHST1 -D-glucopyranose 6-kinase: HK3 MAN1A2 4 -formyl-4 -methyl-5 - linoleate ELOVL7 3 ,7 ,26-triol acetylneuraminyltransferase: fucosyllactotetraosylceramide neolactotetraosylceramide neolactotetraosylceramide neolactosylceramide (3E)-2-oxohex- N-Formyl-L- α CHST11 α α isomer 7A a ganglioside B4GALNT1 KYNU subfamily -D-glucosamine Man-(1->2)- -D-Man-(1->3)-[ - 6-kinase: HK1 1,2,3 galactosyltransferase ST3GAL4 B3GNT2 ST6GAL1 ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide α β α β 3-oxododecanoyl- a fatty acid synthase] (11Z,14Z)-3- fumarate cis-aconitate nicotinamide 5-epimerase: α-D- Man GlcNAc α 4 -carboxy-4 -methyl-5 - cholesta-8,-en-3 -ol,NAD(P) long-chain- sterol 26- ST3GAL3 ganglioside 3'- β-1,3-galactosyltransferase: α-2,3-sialyltransferase: α-2,6-sialyltransferase: L-lysine degradation trans-4-hydroxy-L- L-histidine degradation L-lysine degradation L-tyrosine degradation 3-enedioate propanoyl-CoA kynurenine Carbohydrate α 7 2 B 1,2- - GD1b L-leucine degradation M member 3 [chondroitin]-N- D-Man-(1->2)- -D-Man-(1->6) 2 associated Alpha-2,8- β-galactoside cholesta-8,24-dien-3β-ol H:oxygen oxidoreductase [acyl-carrier- oxoicosadienoyl-CoA α mononucleotide DSE glucose glucopyranose isomer 7A mannosidase: β an N-acetyl-β-D- fatty-acid-- hydrolase: a ganglioside a ganglioside GT2 globo H isoLM1 -2,6- B3GNT2 ST3GAL6 ST6GAL1 ile (pipecolate pathway) proline degradation (saccharopine pathway) heparan sulfate N [heparan sulfate]- acetylgalactosamine sulfotransferase ]-α-D-Man-(1->6)]-β-D-Man- 1,2,3 an N-acetyl- -D- protein] 5β-cholestane-3α,7α,12α-triol ganglioside GD1b α-2,3-N- an α-L-iduronate phosphorylase: HKDC1 α Man GlcNAc protein kinase sialyltransferase alpha-2,6- α β (hydroxylating): MSMO1 CYP27A1 sialyltransferase: adenylyltransferase: propionyl-CoA pyruvate sulfite kynurenine 6-kinase: HK1 B 1,2- - 7 2 MAN1A2 glucosaminyl-R 4 -carboxy-4 -methyl- CoA ligase: GD1a neolactotetraosylceramide Probable -sulfotransferase: glucosamine 3-O- 4-O-sulfotransferase: 2: CHST2 (1->4)-β-D-GlcNAc-(1->4)-α- 3 glucosaminyl-(1,3) synthase: OXSM acetylneuraminyltransferase: ganglioside GT2 β-1,3- succinate-ubiquinone in [dermatan] β-D-glucopyranose isomer 7A p58/GTA: CDK11A 8B: ST8SIA2 sialyltransferase: α a (3R)-3- α α ST6GAL1 a ganglioside leu his tyr NMNAT3 carboxylase: formamidase: mannosidase: 1,2,3 β β 5 -cholesta-8,24- ACSL5 sterol 26- (25R)-3 ,7 -dihydroxy- α-2,3-sialyltransferase: L-isoleucine Hyp G-protein NDST4 sulfotransferase: CHST12 [chondroitin]-N- D-GlcNAc-diphosphodolicholdolichyl-P-Glc:Glc glucose - -D-galactosyl- globotetraosylceramide - 4α-carboxy-4β-methyl-5α-cholesta-8-en-3β-ol ganglioside ST3GAL3 galactosyltransferase: a neolactopentaosylceramide reductase: SDHB aconitate hydratase: ACO2 lys lys sulfite 2 6-kinase: GCK B 1,2-α- β-D-galactosyl-1,4-N- ST6GAL2 dien-3β-ol:NAD(P)+ 3- hydroxytetradecanoyl- (3R,11Z,14Z)-3- β a ganglioside 6'-LM1 α tyrosine nicotinate adenine PCCA PCCB AFMID coupled Man GlcNAc -PP phosphorylase: MAN1A1 1 α (1,4)-N-acetyl-β- 1,3-galactosyltransferase: a 3-oxododecanoyl-[acp] Very long- hydroxylase: 5 -cholestan-26-al GD1a α-2,8- ST3GAL4 SDHA SDHD SDHC aminotransferase: L-leucine L-lysine- - 2-oxoadipate oxidase: arsenous acid heparan sulfate N HS3ST1 acetylgalactosamine 9 2 Man GlcNAc an -D-galactosyl- [acp domain within B3GALT4 [chondroitin]-N- D-glucopyranose 6-phosphate mannosidase: 7 2 acetyl-D-glucosaminyl- oxidoreductase: NSDHL β hydroxyicosadienoyl- CYP27A1 a ganglioside GT1b 3',6'-isoLD1 neolactopentaosylceramide BCAT2 hydroxy- aminotransferase: BCAT2 histidase: aminotransferase: dinucleotide (S)-methylmalonyl- receptor 132 -dolichol α-1,2- HKDC1 isomer 7A (1,3)-β-D-galactosyl- D-glucosaminyl-R α B3GALT5 3 -hydroxysteroid chain sterol 26- sialyltransferase: [+ 2 isozymes] ketoglutarate SUOX -sulfotransferase: [heparan sulfate]- acetylgalactosamine 6-O-sulfotransferase: 1,2,3 α an N-acetyl- - a fatty acid synthase] β L-amino-acid 3-(4- TAT MAN1C1 glycoprotein -2,3-N- CoA β hydrolase: a ganglioside GT1c -1,4-galactosyltransferase: L-proline L-leucine HAL reductase: AASS 2-oxoadipate glutamine- CoA + NDST3 CHST3 glucosyltransferase: β-D- B 1,2-α- (1,4)-N-acetyl-D- β-N-acetylglucosaminylglycopeptide UDP-galactose:β-N- dehydrogenase: NSDHL 3-oxododecanoyl- acyl-CoA (25R)-5 -cholestane- ST8SIA1 L-isoleucine oxidase: IL4I1 L-kynurenine H glucosamine 3-O- [dermatan sulfate]- 4-O-sulfotransferase: Glucose-6-phosphate 1 acetylneuraminyltransferase: neuraminyl-(2->6) 3-dehydro-4-methylzymosterol enoyl-CoA ganglioside B4GALT1 hydroxyphenyl) α-D-Glc-(1->2)-α-D-Glc-(1->3)- Man GlcNAc β [acyl-carrier synthetase: 3α,7α,12α,26-tetraol CYP27A1 aminotransferase: oxidase: aminotransferase: BCAT1 L-saccharopine L-dopa degradation dehydrogenase: dependent methylmalonyl- sulfate ALG10 glucopyranose 7 2 mannosidase: glucosaminyl-R -1,4-galactosyltransferase: β β α α succinate D-threo-isocitrate heparan sulfate N sulfotransferase: L-iduronyl 2-O CHST13 [chondroitin]-N- isomerase: GPI ST3GAL3 - -D-galactosyl- acetyl-glucosamine -1,3- hydratase: a ganglioside GT1a GT1b -2,8- ganglioside GT1c -2,3-N- a ganglioside LM1 4-methyl-2-oxopentanoate urocanate pyruvate DHTKD1 OR17-6 α-D-Glc-(1->3)-α-D-Man-(1->2)- isomer 7A Man GlcNAc -[protein] α 4α-methyl-5α-cholesta-8-en-3-one protein] SLC27A2 sterol 26- (25R)-3α,7α-dihydroxy- neolactopentaosylceramide BCAT1 6-amino-2- PRODH2 NAD(+) CoA epimerase: -sulfotransferase: HS3ST3A1 6-kinase: GCK 1,2,3 MAN1C1 6 2 B4GALT1 (1->4)-N-acetyl-β- galactosyltransferase: 4 -methylzymosterol 3- sialyltransferase: acetylneuraminyltransferase: isocitrate dehydrogenase: sulfotransferase: acetylgalactosamine α-D-Man-(1->2)-α-D-Man-(1->3) D-glucopyranose α (isomer 6A B ) a (2E)-tetradec-2-enoyl- HSD17B4 β β-1,4-galactosyltransferase: oxohexanoate (3R,5S)-3- saccharopine 4-hydroxyphenylpyruvate synthetase: MCEE arsenic triglutathione B 1,2- - 1,2 2 dehydrogenase: HSD17B7 reductase: hydrolase: 5- -cholestanate urocanate kynurenine-α kynurenine 3- F6P 1 α D-glucosaminyl-R B3GALT1 linoleate:CoA ST8SIA1 ST3GAL3 IDH3G IDH3B IDH3A (3S)-3-methyl-2- 4-methyl-2-oxopentanoate glutaryl-CoA NDST2 [heparan sulfate]- UST 6-O-sulfotransferase: α α 6-phosphate an N-acetyl- - an i antigen 4α-methyl-5α-cholesta-8-en- (2E,11Z,14Z)- B4GALT4 hydroxy-1- dehydrogenase: dioxygenase: HPD L-dopa NADSYN1 -[ -D-Man-(1->2)- -D-Man- mannosidase: CBR4 HSD17B8 [acp domain within CYP27A1 hydratase: (R)-methylmalonyl- monooxygenase: Rho a type 1 histo-blood group ligase (AMP- oxopentanoate dehydrogenase: BCKDHB aminoadipate heparan sulfate N glucosamine 3-O- [dermatan] CHST7 neuraminyl-(2->3) a ganglioside a ganglioside succinate-CoA ligase: succinyl-CoA ligase: L-valine degradation pyrroline-5- (1->3)-[α-D-Man-(1->2)-α-D- Glucosamine-- phosphoglucomutase: MAN1A2 α α β 3-one reductase: HSD17B7 a fatty acid synthase] icosatrienoyl-CoA neolactopentaosylceramide AASS glutaryl-CoA CoA GTPase- 4 -methyl-5 -cholesta-8,24-dien-3 -ol (25R)-3α,7α,12α- BCKDHA DBT DLD UROC1 + aminotransferase: KMO containing GDP-mannose biosynthesis -β-D-galactosyl- N-acetyllactosaminide antigen precursor disaccharide a (3R)-3- forming) GQ1b GQ1c SUCLG2 SUCLG1 SUCLA2 SUCLG1 3-methyl-2- carboxylate homogentisate NAD -sulfotransferase: sulfotransferase: Man-(1->6)]-α-D-Man-(1->6)]-β- fructose-6-phosphate PGM2 β-1,4-galactosyltransferase: catechol O- dehydrogenase: activating Man GlcNAc β β α α hydroxydodecanoyl-[acp] : ACSL1 trihydroxy-5β-cholestan-26-al stearate biosynthesis 1-piperideine- 4-imidazolone- methylmalonyl- AADAT NDST1 HS3ST3B1 N-acetyl-D- β 8 2 (1->4)-N-acetyl- - -1,6-N- α 4 -methyl-5 -cholesta-8-en-3-ol α α ganglioside oxopentanoate allysine methyltransferase: D-Man-(1->4)- -D-GlcNAc-(1->4) aminotransferase a 4- -methylzymosterol,NAD(P) (25R)-3 ,7 -dihydroxy- B4GALT2 3-methylbutanoyl-CoA GCDH protein 45 a 2-O-sulfo-α- a β-D-glucuronate phosphoglucomutase: isomer 8A type 1 precursor Le antigen α-2- β-D-galactosyl-1,3-N- sterol 26- val 2-carboxylate 5-propanoate homogentisate CoA mutase: kynurenine galactosamine 1,2,3 D-glucosaminyl-R acetylglucosaminyl- [+ 8 isozymes] β α dehydrogenase: 3-hydroxy- [+ 3 isozymes] -α-D-GlcNAc-diphosphodolichol [isomerizing] 2: GFPT2 D-glucopyranose 6-phosphate H:oxygen oxidoreductase (3R)-3- 5 -cholestanoyl-CoA GQ1c -2,8- α 1,2-dioxygenase: COMT MMUT an arsenite-[arsenite methyltransfera a [heparan L-iduronate in [chondroitin] PGM1 B 1,2-α- transferase: GCNT3 disaccharide 4-L- fucosyltransferase: acetyl-D-glucosaminyl- 4α-methyl-cholesta-8- a myristoyl-[acp linoleoyl-CoA (11Z,14Z)- hydrolase: BCKDHB -aminoadipic (E)-glutaconyl- oxoglutarate L-kynurenine α 1,3 (hydroxylating): MSMO1 hydroxydodecanoyl- palmitate sialyltransferase: a neolactohexaosylceramide ketimine isovaleryl-CoA imidazolonepropionase: Transmembrane O- α in [dermatan] Dolichyl- glutamine:fructose- -D- mannosidase: Man GlcNAc -[protein] Glucose-6-phosphate FUT2 α domain within a alpha-methylacyl- succinyl-CoA 2-oxoglutarate L-4- semialdehyde HGD CoA sulfate]- -D-N- a [heparan dermatan 4- [chondroitin 6 2 fucosyltransferase: glycoprotein -2,3-N- enol,NAD(P)H:oxygen icosadienoyl-CoA CYP27A1 long-chain- BCKDHA DBT DLD L-valine reductase: AMDHD1 aminotransferase: AXOR35 glucopyranose Man GlcNAc isomerase: GPI N-acetyllactosaminide [acp] dehydratase: linoleoyl-CoA CoA racemase: icosapentaenoate ST8SIA1 hydroxyglutamate dehydrogenase: IVD methyltransferase: succinyl-CoA sulfoglucosamine sulfotransferase: sulfate]-D- diphosphooligosaccharide-- 6-phosphate MAN1A1 (isomer 6A B ) 6 2 FUT3 acetylneuraminyltransferase: 4α-hydroxymethyl-5α-cholesta-8,24-dien-3β-ol oxidoreductase fatty acid synthase] oxoglutarate (2S)-2- aminotransferase: dehydrogenase: 4-maleyl- glutaryl-CoA GOT2 sulfate]-α-D- a [chondroitin-sulfate] 1,2 1 β HTD2 (25R)-3α,7α,12α-trihydroxy- fatty-acid--CoA biosynthesis III (8- a ganglioside dihydrolipoyllysine-residue CRYM kynurenine kynureninase: protein glycosyltransferase amidotransferase: GFPT1 1-phosphate isomer 6A F6P -1,6-N- an H type 1 histo- 6-desaturase: AMACR neolactohexaosylceramide neolactohexaosylceramide dehydrogenase: OGDH semialdehyde ALDH7A1 LRTOMT glucosamine CHST14 glucuronyl 2-O 1,2 ST3GAL3 (hydroxylating): MSMO1 5β-cholestan-26-oate ligase: ACSL5 methylbutanoyl- BCAT2 N-formimino- acetoacetate dehydrogenase: kynurenine containing 4-O-sulfo- B 1,2-α- CMP-2-keto-3-deoxy- acetylglucosaminyl- α α FADS2 α α desaturase, mammals) GP1c β-1,3-galactosyltransferase: α-2,3-sialyltransferase: succinyltransferase: DLST L-4- 3-methylcrotonyl-CoA aminotransferase: KYNU subunit 4: OST4 glucose-1-phosphate 2 blood group antigen 4 -hydroxymethyl-5 - a (2E)-dodec- (25S)-3 ,7 -dihydroxy- L-pipecolate β [heparan sulfate]- [heparan- 3-sulfate sulfotransferase: N-acetylgalactosamine a Lewis a epitope CoA L-valine L-glutamate maleylacetoacetate 3-O-methyldopa GCDH -alanine degradation aminotransferase: D-glucosamine 6-phosphate mannosidase: Mannose-6-phosphate D-glycero-D-galacto- transferase: GCNT2 α β 4α-hydroxymethyl-5α-cholesta-8-en-3β-ol a [glycerolipid]- very long- β palmitate-CoA α-linolenate B3GNT2 ST3GAL6 hydroxyglutamate AADAT a methylarsenite-[arsenite glucosamine 3-O- sulfate]-6-O- [dermatan sulfate] UST [+ 6 isozymes] guanylyltransferase an N-acetyl- -neuraminyl- cholesta-8,24-dien-3 - 2-enoyl-[acp] 5 -cholestanoyl-CoA 2-methylbutanoyl- 3-methylcrotonyl- L-2-aminoadipate MUC-21 GDP-L-fucose a 3-oxohexadecanoyl- γ-linolenoyl-CoA aminotransferase: isomerase: GSTZ1 KYAT1 MAN1C1 isomerase: MPI nononate biosynthesis a β-D-Gal-(1->4)-β- H type 1 antigen 4-L- type 1 H-antigen N-acetyl-α- type 1 H-antigen N-acetyl-α- β (11Z,14Z)- chain acyl-CoA ligase: SLC27A2 α semialdehyde crotonyl-CoA methyltransferase] sulfotransferase: sulfotransferase: containing 4-O β (2->3)- -D-galactosyl-(1->3) ol,NAD(P)H:oxygen -linolenate--CoA CoA 1-piperideine CoA carboxylase: kynurenine-- 3-hydroxyanthranilate [heparan biosynthesis I (from a 2-O-sulfo- - [chondroitin]-N- a [chondroitin-sulfate] Glucosamine 6-phosphate GDP-α-D-glucose Man GlcNAc -[protein] 4α-hydroxymethyl-5α- (2E)-dodec- [acp domain within synthetase: a sialyl-(2,3)- BCAT1 L-pipecolate glutamate Glc Man GlcNAc -[protein] 6 2 D-GlcNAc-(1->3)- fucosyltransferase: D-galactosaminyltransferase: D-galactosaminyltransferase: β icosadienoate palmitate:CoA dehydrogenase: 4-fumaryl- L-asparagine degradation β kynurenine-- -sulfo-N-acetyl- 3 9 2 D-mannopyranose -N-acetyl- -D-glucosaminyl-R oxidoreductase ligase: ACSL1 a neolactoheptaosylceramide 6-carboxylate 2-aminoadipate- -alanine oxoglutarate HS3ST1 sulfate]-α-D-N- HS6ST3 GDP-D-mannose) D-glucuronate acetylgalactosamine containing 6-O-sulfo- N-acetyltransferase: Man GlcNAc D-mannopyranose 6-phosphate 2-enoyl-[acp] 3-oxodihomo dehydrogenase: oxidase: MCCC2 MCCC1 formimidoyltransferase: (isomer 6A ) 6 2 [β-D-GlcNAc-(1->6) cholesta-8-en-3β-ol,NAD(P) a fatty acid synthase] SLC27A2 anandamide biosynthesis II sphingolipid biosynthesis (mammals) biotin-carboxyl carrier neolactohexaosylceramide 3-methyl-2- crotonyl- oxoglutarate D-galactosamine 1,2,3 mannose FUT3 ABO-B ABO (hydroxylating): MSMO1 ligase (AMP- [+ 4 isozymes] icosapentaenoate docosahexaenoate biosynthesis reductase: ALDH4A1 2-oxoglutarate acetoacetate β alanine transaminase: 3-hydroxyanthranilate methylarsonous acid Olfactory sulfoglucosamine 3- in [chondroitin] 4-sulfate 6-O- N-acetylgalactosamine GNPNAT1 isomer 6A α-N-acetylneuraminyl- reductase: γ-linolenoyl- ACADSB PIPOX FTCD [heparan sulfate]- [heparan- [dermatan]-N- GDP-α-D-mannose 1,2 ]-β-D-Gal-(1->4) H:oxygen oxidoreductase (24E)-3α,7α-dihydroxy- α protein assembly neolactoheptaosylceramide a [2-oxoglutarate dehydrogenase E2 oxobutanoate erythro-4- 3-methoxy-4- CoA transaminase: α Phosphomannomutase phosphorylase: β Bile acyl-CoA forming): ACSL1 -linolenoyl-CoA biosynthesis II (6- IV (4-desaturase, mammals) (E)-2- PYCR1 3-methylglutaconyl-CoA aminotransferase: aminotransferase: KYAT3 3,4-dioxygenase: HAAO methyltransferase: receptor O-sulfotransferase: sulfotransferase: B 1,2- - (2->3)- -D-galactosyl- MECR CoA 6 fumarylacetoacetate glucosamine 3-O- sulfate]-6-O- acetylgalactosamine GDP- glucosamine-phosphate Man GlcNAc 1 -β-D-GlcNAc-R a B type 1 histo- an A type 1 histo- 4α-formyl-5α-cholesta-8,24-dien-3β-ol (hydroxylating): MSMO1 5β-cholest-24-enoyl-CoA β-1,4-galactosyltransferase: protein] N -S-succinyldihydrolipoyl-L-lysine hydroxy-L- hydroxyphenylpyruvate hydratase: asn KYAT3 6 2 HKDC1 synthetase: [+ 4 isozymes] arachidonoyl-CoA desaturase, mammals) palmitoyl-CoA methylcrotonoyl- 3-methyl-2- AADAT ABAT 2-amino-3- TRMT112 N6AMT1 9K2 HS3ST1 CHST15 mannosidase: 1: PMM1 D-mannopyranose a Lewis b epitope (1->3)-N-acetyl-β- synthase: a [glycerolipid]-di- (5Z,8Z,11Z,14Z,17Z) a [biotin carboxyl- 1-piperideine hydrolase: FAH sulfotransferase: sulfotransferase: 4-sulfate 6-O- mannose 4,6 N-acetyltransferase isomer 6A 1,2- β-N-acetylglucosaminylglycopeptide blood group antigen blood group antigen a (3R)-3- SLC27A5 palmitoyl-CoA 3-oxo- B4GALT1 oxobutanoate glutamate methylglutaconyl- ECHS1 N 4 -(β-N-acetyl- 3-oxopropanoate 4-(2-amino-3- 1,2,3 MAN1C1 Phosphomannomutase D-glucosamine 4-L- α α 4α-formyl-5α-cholesta-8-en-3β-ol a dodecanoyl-[acp] ELOVL7 homo-γ-linolenate α-linolenate -icosapentaenoyl-CoA carrier protein]-L-lysine CoA 6-carboxylate 5-formimidoyltetrahydrofolate glu carboxymuconate- HS3ST2 HS6ST2 sulfotransferase: dehydratase: 1: GNPNAT1 α-mannosidase: 6-phosphate β B type 1 antigen 4-L- A type 1 antigen 4-L- 4 -formyl-5 -cholesta- hydroxyhexadecanoyl- icosatrienoyl- serine enoyl-CoA dehydrogenase: erythro-4-hydroxyl- CoA hydratase: AUH 2-oxoadipate enoyl-CoA D-glucosaminyl) 4-(2- hydroxyphenyl) itaconate a [chondroitin-sulfate] mucin core 3 and core 2: PMM2 -1,4-galactosyltransferase: fucosyltransferase: (25R)-3α,7α,12α-trihydroxy- α-linolenate--CoA Biotin--[acetyl- fumarate 6-semialdehyde 8,24-dien-3β-ol,NAD(P) a neolactooctaosylceramide Other Biosynthesis α-aminoadipic L-asparaginase: a dimethylarsenite- HG57 [+ 3 isozymes] [heparan- biosynthesis I CHST15 GMDS 4 O-glycosylation UDP-N-acetyl-D- MAN1C1 B4GALT1 fucosyltransferase: fucosyltransferase: α α [acp domain within 3-oxo-dihomo 3-oxooctadecanoyl- CoA synthase: 3-oxo- palmitoyltransferase: hydratase: BCKDHB L-glutamate formimidoyltetrahydrofolate hydratase: -L-asparagine malonate aminophenyl)-2,4- -2,4- GDP-4-dehydro- containing 4,6-di- N-acetyl-D-glucosamine 6-phosphate FUT3 4 -formyl-5 -cholesta- 5β-cholestanoyl-CoA (24R,25R)-3α,7α,24- ligase: ACSL1 CoA-carboxylase] 2-amino 3- [dermatan sulfate] H:oxygen oxidoreductase γ CoA synthase: docosapentaenoyl- semialdehyde 2-oxoadipate ASPG semialdehyde dioxobutanoate [arsenite methyltransferase] sulfate]-6-O- α galactosamine Man GlcNAc α-D-mannose 1-phosphate FUT3 FUT3 β a fatty acid synthase] -linolenoyl- ELOVL5 SPTLC3 neolactooctaosylceramide ECHS1 BCKDHA DBT DLD aminotransferase: HMG-CoA cyclodeaminase: FTCD HADHA dioxobutanoate -D-rhamnose O-sulfo-N-acetyl- a [glycoprotein]- 6 2 8-en-3 -ol,NAD(P) S-medium- 3-oxotetradecanoyl- alpha-methylacyl- trihydroxy-5β- [+ 4 isozymes] ligase: HLCS 3-methoxy-4- carboxymuconate a [heparan containing 4,6-di- an I antigen (hydroxylating): MSMO1 ELOVL7 1-arachidinoyl-sn- CoA synthase: dehydrogenase: dehydrogenase: homovanillate dehydrogenase: sulfotransferase: cis-aconitate biosynthesis I isomer 6A 1,2- 3-deoxy-D-glycero- a B (Lewis b) histo- an N-acetyl-α-D- a sialyl-Lewis a epitope CoA (11Z,14Z,17Z)-3- SPTLC1 SPTSSA α-2,3-sialyltransferase: eumelanin biosynthesis (2S,3S)-3- GOT2 L-asparaginase: L-asparaginase: (L-serine/L- phosphoacetylglucosamine 1,2,3 H:oxygen oxidoreductase chain-acyl- [acyl-carrier-protein] a [glycerolipid]- cholestanoyl CoA α-linolenoyl-CoA a 5,10- hydroxyphenyllactate enoyl-CoA 6-semialdehyde sulfate]-α-D-N- O-sulfo-N-acetyl- GDP-L-fucose D-galactosamine UDP-N-acetyl- Mannose-1-phosphate synthase: CoA racemase: glycerol 3-phosphate ELOVL2 a [biotin carboxyl-carrier L-dopa and L- isobutanoyl-CoA ALDH7A1 3-hydroxymethyl-3- DHTKD1 AGA ASRGL1 ALDH6A1 HS6ST1 threonine) α-mannosidase: D-galacto-nononate blood group epitope galactosaminyl-(1,3)[α- α α β (hydroxylating): MSMO1 arachidonate palmitoyl oxoicosatrienoyl- serine ST3GAL6 hydroxy-2- (4R)-4-hydroxy- hydratase: decarboxylase: sulfoglucosamine D-galactosamine synthetase: polypeptide N- mutase: PGM3 α-D-glucosamine 4 -carboxy-5 -cholesta-8,24-dien-3 -ol [fatty acid synthase: OXSM AMACR protein]-N 6 -biotinyl-L-lysine dopachrome methylglutaryl-CoA methenyltetrahydrofolate MCT 11 PRPP biosynthesis MAN1A2 guanyltransferase 9-phosphate L-fucosyl-(1,2)]-β-D- ELOVL5 elongase: CoA synthase: α-linolenoyl-CoA 3-oxo- methylbutanoyl- TSTA3 acetylgalactosaminyltransferase: UDP-N- synthase] a (2E)-hexadec-2-enoyl- α α α palmitoyltransferase: a sialyl-(2,3)- L-dopachrome biosynthesis isobutyryl-CoA 2-oxoglutarate lyase: HMGCLL1 glutaryl-CoA ECHS1 CO ACMSD methylarsonous acid 3-O-sulfate a [heparan α beta: GMPPB α α α 4α-carboxy-5α-cholesta-8-en-3β-ol (25S)-3 ,7 ,12 -trihydroxy- ELOVL6 CoA L-2-aminoadipate methenyltetrahydrofolate 2 kynurenate cis-aconitate N-acetyl- -D-glucosamine 1-phosphate acetylglucosamine Man GlcNAc galactosyl-(1,3)-[ -L- 4 -carboxy-5 -cholesta- 3-oxodihomo γ- ELOVL7 6-desaturase: icosapentaenoyl- SPTLC2 neolactoheptaosylceramide (S)-3- xanthurenate (2Z,4E)-2-amino- GDP-4-dehydro-6- GALNT1 8 2 thioesterase: [acp domain within β dehydrogenase: asp trimethylarsane methyltransferase: sulfate]-α-D-N- D-ribose 5- fucosyl-(1,4)]-N-acetyl-β-D- β a 3-oxotetradecanoyl- 5 -cholestanoyl-CoA α α FADS2 CoA synthase: Macromolecule Modification 3-hydroxy-2- hydroxymethylglutaryl- cyclohydrolase: MTHFD1 6-oxohexa- deoxy-β-L-galactose 4-epimerase:α GALE isomer 8A Mannose-1-phosphate 8,24-dien-3 -ol:NAD(P)+ α α OLAH linolenoyl-CoA 3 ,7 -dihydroxy-24- (11Z,14Z,17Z)-3- SPTLC1 SPTSSA tyr ACAD8 4-hydroxy-2- hydroxybutanoyl- TRMT112 N6AMT1 phosphate [+ 18 isozymes] UDP-N-acetyl- - 1,2,3 4 -carboxy-5 -cholesta- [acp] a fatty acid synthase] 3-oxooctadecanoyl-CoA 2-aminoadipate- CoA lyase: HMGCL L-phenylalanine degradation sulfoglucosamine cis-aconitate glucosamine-(1->protein] peroxisomal acyl- β a 1-arachidonoyl-2-acyl- ELOVL5 a [biotin carboxyl- Short methylbutyryl-CoA 10 L-threonine degradation 2,4-dienoate APP GDP-L-fucose ribose-phosphate a Tn antigen UDP-N-acetylglucosamine B 1,2-α- guanyltransferase 3-oxidoreductase: NSDHL β (3R)- oxo-5 -cholestanoyl CoA oxoicosatrienoyl-CoA oxoglutarate an N - CoA D-galactosamine 1,3 8-en-3 -ol:NAD(P)+ 3- stearidonoyl-CoA tyrosinase: 2-oxoglutarate aspartate 6-O-sulfate decarboxylase: Kdn long-chain fatty coenzyme A sn-glycerol 3-phosphate 3-dehydrosphinganine carrier-protein dimer]- transient dehydrogenase: synthetase: pyrophosphokinase: UDP-α-D-xylose biosynthesis pyrophosphorylase: mannosidase: alpha: GMPPA 3-oxotetradecanoyl- hydroxydihomo 3-oxooctadecanoyl- (5Z,8Z,11Z,14Z,17Z)-3- protein ubiquitination methylacrylyl-CoA aldolase: acetoacetate formyltetrahydrofolate (3S)-3- [heparan zymosterone oxidoreductase: NSDHL 6 TYR aminotransferase: aminotransferase: ACOD1 HS02988 laurate acid activation oxidase: ACOX2 N -biotinyl-L-lysine receptor 5,6- wybutosine biosynthesis HSD17B10 aminomuconate- PRPS1L1 MAN1A1 [acyl-carrier γ-linolenoyl- CoA reductase: phosphatidate oxodocosapentaenoyl-CoA HOGA1 a 5,6,7,8-tetrahydropteridine hydroxyacyl-CoA L-glutamine α TSTA3 α 3-oxo- dopaquinone thr GOT1 sulfate]- -D-N- GDP- -D-mannose a palmitoyl-[acp (24E)-3α,7α,12α-trihydroxy- 3-ketodihydrosphingosine potential dihydroxyindole a [ubiquitin] C- enoyl-CoA AADAT semialdehyde ribose-phosphate α UDP-N-acetylglucosamine 5α-cholesta-8-en-3-one protein] reductase: CoA reductase: HSD17B12 phosphatase: PLPP4 3-oxodocosapentaenoyl- acetyl-CoA biotin 3-hydroxy-2- dehydrogenase: degradation Protocadherin sulfoglucosamine- itaconate UDP- -D-glucose 5α-cholesta-8,24-dien-3- a long-chain (3R,11Z,14Z,17Z)-3- icosatetraenoyl- reductase: KDSR hydratase: L-threonine dimethylarsonite GDP-β-L-fucose CBR4 HSD17B8 domain within a 5β-cholest-24-enoyl-CoA carboxylase: carboxylase: channel terminal glycine 37 Phe dehydrogenase: gamma-A8 pyrophosphokinase: UDP-glucose 6- pyrophosphorylase: UAP1 HSD17B12 fatty acid chenodeoxycholoyl-CoA (3R)-3- [+ 6 isozymes] CoA synthase: CoA reductase: 5,6-dihydroxyindole guanine in tRNA methylacyl-CoA 2-oxoadipate HADH oxaloacetate 6-O-sulfate 3-O- core 3 one reductase: HSD17B7 α fatty acid synthase] long- hydroxyicosatrienoyl- 1: TRPC1 ECHS1 glyoxylate pyruvate deaminase: SDSL ALDH8A1 picolinate PRPS1 α CMP-Kdn 5 -cholesta-8-en-3-one a (3R)-3- HSD17B12 ACACA ACACA fatty acid biosynthesis initiation monooxygenase: ubiquitin:[E1 tRNA (guanine-N(1)- dehydrogenase: L-serine gln sulfotransferase: dehydrogenase: UGDH UDP-N-acetyl- -D-glucosamine (3R)-hydroxydihomo hydroxyoctadecanoyl-CoA CoA ELOVL5 sphinganine L-threonine (3S)-3- UDP-α-D-glucuronate core 4 β-1,6-N- reductase: HSD17B7 hydroxytetradecanoyl- chain-fatty- a 1-arachidonoyl-2-acyl-sn-glycerol (animals and fungi, cytoplasm) L-dopachrome TYR ubiquitin- )-methyltransferase: HADHA (S)-3-hydroxy- 2-oxoadipate degradation L-proline glutaminase: GLS HS3ST1 ribose-phosphate zymosterol γ-linolenoyl-CoA Bile acid- Bile acid- enoyl-CoA (8Z,11Z,14Z,17Z)-3- (3R,5Z,8Z,11Z,14Z,17Z)-3- biotin biotin hydroxyacyl-CoA acetylglucosaminyltransferase: [acp] acid--CoA TRMT5 isobutanoyl-CoA dehydrogenase: degradation phenylalanine deaminase: SDS (2Z,4E)-2- a [heparan α α α carboxylase: carboxylase: tautomerase: leucodopachrome activating 1 37 glutaminase: GLS2 AE 3 pyrophosphokinase: UDP-glucuronic acid (3R)-3- (24R,25R)-3 ,7 ,12 ,24- CoA:amino acid N- CoA:amino acid N- hydratase: oxoicosatetraenoyl-CoA hydroxydocosapentaenoyl-CoA dihydroceramide indole-5,6- an N -methylguanine 2-methylacetoacetyl- hydroxylase: PAH 2-oxobutanoate dehydrogenase: sulfate]-α-D-N- GCNT3 ∆ 8 ∆ 24 -cholestadien-3β- zymostenol ligase: acetyl-CoA DCT enzyme] DHTKD1 aminomuconate PRPS2 decarboxylase 1: UXS1 tetrahydroxy-5β- HSD17B4 synthase: CERS1 ACACB ACACB acetyl-CoA quinone in tRNA Phe CoA 3-hydroxyisobutanoyl- ser tyr HADH [+ 2 isozymes] 7 8 hydroxytetradecanoyl- ACSL1 acyltransferase: acyltransferase: cacodylate dimethylarsino-gluta sulfoglucosamine Man GlcNAc - ol ∆ -∆ -isomerase: EBP (2E,11Z,14Z,17Z)- a [carboxyl-carrier ligase: UBA1 CoA hydrolase: HIBCH pro 2-oxobutanoate PRPP core 4 5 2 palmitate palmitoyl-CoA cholestanoyl CoA BAAT BAAT acetyl-CoA tRNA-4- glutaryl-CoA glycine cleavage serine 3-hydroxyacyl-CoA L-glutamate degradation glu α [acp] dehydratase: HTD2 6 5,6- HLA class I 3,6-O-bissulfate UDP- -D-xylose [protein] (isomer 5A ) (2E,8Z,11Z,14Z)- Very long- (2E)-octadec-2-enoyl-CoA icosatetraenoyl-CoA a 1-arachidonoyl-2-acyl-sn a dihydroceramide protein dimer]-N - acetyl- proline dehydrogenase: 1,2 oleate carboxylase: NEDD8- demethylwyosine acetyl-CoA (S)-3-hydroxy- dehydratase: Dihydropteridine dehydrogenase: (via 4-aminobutanoate) α β ∆ 7 ∆ 7 dihydroxyindole- ophthalmate histocompatibility 5 -cholesta-7,24-dien-3 -ol -cholestenol - a (2E)-tetradec- palmitoyl-CoA icosatetraenoyl-CoA chain -glycero-3-phosphocholine (3R,8Z,11Z,14Z,17Z)-3- (2E,7Z,10Z,13Z,16Z,19Z) carboxybiotinyl-L-lysine CoA:[acyl- a [glycine- dehydrogenase: BCKDHB ACACA activating synthase: TYW1 acetyltransferase: isobutanoate SDSL reductase: QDPR HADHA (3E)-2-oxohex- ∆ 8 biosynthesis 2-carboxylate antigen, C -isomerase: EBP 2-enoyl-[acp] hydrolase acyl-CoA glycochenodeoxycholate taurochenodeoxycholate phosphatidylcholine:plasmenylethanolamine hydroxyicosatetraenoyl-CoA -docosahexaenoyl-CoA dihydroceramide carrier protein] biosynthesis L-dopachrome cleavage complex PRODH BCKDHA DBT DLD enzyme E1 37 ACAT2 (S)-1-pyrroline- 3-enedioate 3α,7α,12α-trihydroxy-24- 4-desaturase: acetyl-CoA 5,6- 4-demethylwyosine 3-hydroxyisobutyrate 6 L-serine 3-hydroxyacyl-CoA glu alpha chain synthetase: N-arachidonoyltransferase: PLAAT1 transacylase: H protein] N -[(R glycine 5α-cholest-7,24-dien-3β- (2E)-tetradec- palmitoyl-CoA catalytic Phe 5-carboxylate L-alanine a 6,7-dihydropteridine a 4a-hydroxytetrahydropteridine stearoyl-CoA oxo-5-β-cholestanoyl CoA (11Z,14Z,17Z)- DEGS1 carboxylase: dihydroxyindole- 2-oxobutanoate in tRNA 2-methylacetoacetyl- dehydrogenase: dehydratase: propanoyl-CoA dehydrogenase: glutamate 24 SLC27A2 FASN )-lipoyl]-L-lysine dehydrogenase: degradation ol,NAD(P)H:oxygen 5- lathosterol:NADP+ ∆ - Fatty acid 2-enoyl-[acp] hydrolase: phosphatidylcholine:plasmenylethanolamine subunit: CoA thiolase: ACAT1 HIBADH dihomo γ- stearoyl-CoA icosatrienoyl-CoA a sphingosine ACACB 2-carboxylic acid (S)-2- 2-aminoprop-SDS HSD17B10 decarboxylase: GLUL oxidoreductase: KCNH7 oxidoreductase: DHCR24 reductase: ACOT4 [+ 3 isozymes] N-arachidonoyltransferase: PLAAT2 an acetyl-[acp UBA3 dihydrolipoyl GLDC Shank3 desaturase linolenoyl-CoA a long-chain (2E,8Z,11Z,14Z,17Z) (7Z,10Z,13Z,16Z,19Z) oxidase: TYRP1 aminobutanoate (S)-methylmalonate- (11Z,14Z,17Z)- ceramide domain within a 2-enoate glutamate 6: FADS6 MECR palmitoyl-CoA fatty acyl-CoA stearoyl-CoA phosphatidylcholine:plasmenylethanolamine malonyl-CoA aminotransferase: [+ 3 isozymes] dehydrogenase: ala acetoacetyl-CoA 2-oxoadipate superpathway of inositol phosphate compounds Secondary Metabolite Biosynthesis icosatrienoyl- acyl-CoA hydrolysis icosa-11,14,17- -icosapentaenoyl-CoA -docosapentaenoyl-CoA fatty acid synthase] 5,6-dihydroxyindole- acetyl-CoA propanoyl-CoA semialdehyde decarboxylase: GAD2 superpathway of morphine biosynthesis palmitoyl ethanolamide biosynthesis D-myo-inositol (1,4,5)-trisphosphate biosynthesis vitamin D thyroid hormone biosynthesis hydrolase: hydrolase N-arachidonoyltransferase: PLAAT3 Sphingomyelin sphingomyelin 7-[(3S)-3-amino-3- DLD L-glutamate-5- 3 [+ 2 isozymes] GOT1 an [E1 ubiquitin- alanine catecholamine 15-epi-lipoxin biosynthesis 7-dehydrodesmosterol CoA 5- choloyl-CoA trienoyl-CoA docosapentaenoyl- 2-carboxylate carboxypropyl]-4- a [glycine- acetyl-CoA glutamate geranylgeranyldiphosphate biosynthesis oleoyl-CoA a myristoyl-[acp] ACOT2 a 2,3,4-saturated stearoyl-CoA phosphatidylcholine:plasmenylethanolamine phosphodiesterase: synthase: (S)-2- activating semialdehyde aminotransferase: 2-oxoadipate 37 3-amino-2- methylmalonate a [glycine-cleavage Protein biosynthesis lathosterol desaturase: 8-desaturase: CoA 4-desaturase: acetoacetyl- monooxygenase: acetyltransferase: decarboxylase: GAD1 biosynthesis I (via mevalonate) myo-inositol a [thyroglobulin]- SMPD4 SGMS1 demethylwyosine cleavage complex 6 dehydrogenase: (S)-reticuline palmitoyl-CoA myo-inositol 7-dehydrodesmosterol- [+ 6 isozymes] fatty acyl CoA hydrolase: N-arachidonoyltransferase: PLAAT4 aminobutanoate enzyme]-S- semialdehyde complex H protein] N - L-glutamate γ- GPT2 4-aminobutanoate FAM171A1 oleoyl-CoA FADS1 Cytosolic acyl FADS2 FADS2 [acp] TYR in tRNA Phe methylpropanoate H protein] N 6 - 2-iminopropanoate ACAT2 7-dehydrocholesterol L-tyrosine arachidonate 5α-cholest-7-en-3β- S-tetradecanoyl- Bile acid- Bile acid- ACOT4 phosphatidylcholine:plasmenylethanolamine (8Z,11Z,14Z,17Z)- [+ 5 isozymes] [+ 2 isozymes] ubiquitinyl- DHTKD1 acetyl-CoA reductase: DHCR7 indole-5,6- Phe aminotransferase: dehydrogenase: aminomethyldihydrolipoyl- semialdehyde alanine pterin-4-alpha- phosphatidylinositol hydrolase palmitate coenzyme (8Z,11Z,14Z,17Z)- (4Z,7Z,10Z,13Z,16Z,19Z) synthase: glutamate--2- RNA -4-demethyl- dihydrolipoyl- acetyl-CoA tyr ol,NAD(P)H:oxygen 5- [fatty acid icosatetraenoyl-CoA acetyl-CoA phosphatidylinositol Thyroid arachidonoyl-CoA CoA:amino acid N- CoA:amino acid N- stearoyl-CoA N-arachidonoyltransferase: PLAAT5 an N-acyl- FASN quinone-2- aminobutanoate L-cysteine ABAT ALDH6A1 L-lysine dehydrogenase: aminotransferase: carbinolamine glutaryl-CoA synthase: CDIPT 15R-HETE oleoyl-CoA synthase] A thioester icosatetraenoyl-CoA -docosahexaenoyl-CoA 7-(3-amino-3- L-lysine acetyltransferase: Prostacyclin acetyltransferase: ACAT2 tyrosine 1-palmitoyl-sn- synthase: CDIPT peroxidase: desmosterol oxidoreductase: KCNH7 acyltransferase: acyltransferase: hydrolase: an N-(arachidonoyl) icosatetraenoyl- sphingosylphosphorylcholine carboxylate ALDH4A1 GPT dehydratase: PCBD2 hydrolase: ligase: carboxypropyl) ACAT1 receptor hydroxylase: TH a 1-phosphatidyl- pre-vitamin D TPO synthase: PTGS2 hydrolase: thioesterase: BAAT BAAT icosatetraenoyl- ubiquitin- N-terminal pyruvate acetyl-CoA 1,2- glycerol 3-phosphate a 1-phosphatidyl- 3 ACOT2 ethanolamine plasmalogen CoA 5- an acetoacetyl-[acp GCLC GCLM S-ubiquitinyl- 4 pterin-4α-carbinolamine 7-dehydrocholesterol ACOT4 OLAH ACOT7 sphingomyelin wyosine-N ]- (S)-3-amino-2- hydrogencarbonate 1D-myo-inositol CoA 5- conjugating E2 ubiquitin- glu a [thyroglobulin]- 24 desaturase: domain within a [E1 ubiquitin- acetyltransferase: ACAT1 dehydroreticuline L-dopa 1D-myo-inositol (15R)-hydroxyicosapentaenoate cholesterol:NADP+ ∆ - [+ 3 isozymes] deacylase γ-L-glutamyl-(S)- methyltransferase: methylpropanoate aminomethyltransferase: pyruvate dehydratase: PCBD1 acetyl-CoA oleoyl-CoA [+ 2 isozymes] desaturase: enzyme conjugating acetoacetyl-CoA 3-iodotyrosine a 2,3,4-saturated FADS1 fatty acid synthase] activating AMT Transmembrane phosphatidylinositol oxidoreductase: DHCR24 tetradecanoate glycocholate taurocholate a [glycerolipid]- 2-aminobutanoate TYW3 phosphatidylinositol phosphatidylinositol ∆ 7 hydrolase: stearate FADS1 E2 (E3- enzyme: dopa cholesterol:NADP+ - fatty acid (5Z,8Z,11Z,14Z,17Z) coenzyme A (4Z,7Z,10Z,13Z,16Z,19Z) sphingosylphosphorylcholine enyzyme]-L- 7-[(3S)-(3-amino- protein 8B 4-kinase: PI4KB melanochrome ophthalmate UBE2W hydroxymethylglutaryl- decarboxylase: 4-kinase: PI4KB 3-kinase: a 1-palmitoyl-2-acyl-sn Thyroid oxidoreductase: DHCR7 ACOT2 (5Z,8Z,11Z,14Z,17Z) -icosapentaenoyl-CoA cysteine:[E2 independent) 3-carboxypropyl)]- phosphatidylinositol resolvin D biosynthesis vitamin D a 2-lyso-(N-arachidonoyl) -docosahexaenoate synthetase: CoA synthase: HMGCS1 phosphatidylinositol PIK3C3 PIK3R4 -glycerol 3-phosphate 3 peroxidase: Thyroid [+ 3 isozymes] -icosapentaenoyl-CoA anandamide ubiquitin- : UBE2O 37 Phe (R)-reticuline DDC (5S,6E,8Z,11Z,13E,15R)-5- ethanolamine plasmalogen wyosine in tRNA hydroxymethylglutaryl- 4 kinase: PI4KA 4 kinase: PI4KA TPO peroxidase: GSS an [N-terminal glutathione-mediated detoxification I Phosphatidylinositol conjugating 7-(3-amino-3- Integrin phosphatidate a [glycerolipid]-(4Z,7Z,10Z,13Z,16Z,19Z) vitamin D 25- hydroperoxy-15-hydroxyicosa- oleate purine nucleotides degradation Nucleoside and Nucleotide Degradation nicotine degradation V α-tocopherol degradation CoA synthase: HMGCS2 dopamine phosphatidylinositol TPO cholesterol enzyme] an [(E3- E2 ubiquitin- superpathway of pyrimidine beta-6 phosphatidylinositol 3-kinase catalytic phosphatase: hydroxylase: 6,8,11,13-tetraenoate ophthalmate carboxypropyl) UTP and CTP dephosphorylation I thymine degradation 4-kinase: PI4K2A -docosahexaenoate independent) conjugating β 4-kinase: PI4K2A subunit type 3: PIK3C3 a [thyroglobulin]- a [thyroglobulin]- (15R)- ubiquitinyl -wyosine ribonucleosides degradation RX HMG-CoA dopamine - PLPP4 CYP2R1 POR Nucleoside and Nucleotide Biosynthesis eumelanin enzyme]-S- α phosphatidylinositol 3,5-diiodotyrosine triiodothyronine transferase: E2 ubiquitin- methyltransferase: AMP (S)-nicotine -tocopherol E3 ubiquitin- monooxygenase: phosphatidylinositol Phosphatidylinositol- hydroxyarachidonate UTP thymine [+ 6 isozymes] ubiquitinyl- cytidine glutathione S superpathway of steroid hormone biosynthesis 4-kinase: PI4K2B calcidiol Thyroid Amino Acid Biosynthesis UBE2D2 conjugating LCMT2 IMP α-tocopherol ω- protein 3-hydroxy-3- salutaridine DBH 4-kinase: PI4K2B 4,5-bisphosphate [thyroglobulin]- 5-lipoxygenase: ALOX5 cytidine dihydrothymine nicotine,NADPH:oxygen a 1-palmitoyl-2- a 1-phosphatidyl- purine nucleotides de novo biosynthesis enzyme]-S- L-cysteine AMP 5'- -transferase: hydroxylase: CYP4F2 ligase methylglutaryl-coenzyme 3-kinase catalytic (4Z,7Z,10Z,13Z,16Z,19Z) peroxidase: 3,5,3'-triiodo- (7E,9E,11Z,13E,15R)- superpathway of pyrimidine purine deoxyribonucleosides salvage Metabolic Regulator Biosynthesis 7-[(3S)-4-methoxy- UTP CTP synthase: CTPS1 dehydrogenase: superpathway of purine nucleotide salvage fructose 2,6- [+ 32 isozymes] deaminase: CDA oxidoreductase: CYP2A6 a 1-phosphatidyl- acyl-sn-glycerol 1D-myo-inositol 25- citrulline-nitric oxide cycle carnosine ubiquitinyl- N-terminal (3-amino-3- nucleotidase: inosine-5'- GSTZ1 13'-hydroxy-α-tocopherol MARCH1 A reductase: HMGCR (R)-noradrenaline subunit gamma cholesterol -docosahexaenoate TPO L-thyronine (5S,6S)-5,6-epoxyicosa-15- deoxyribonucleotides de novo biosynthesis L-cysteine biosynthesis bisphosphate biosynthesis L-carnitine biosynthesis uridine diphosphohydrolase: CTP synthase: CTPS2 DPYD 4-phosphate hydroxyvitamin L-methionine salvage cycle glutamine L-proline ornithine de novo serine and glycine biosynthesis hypusine biosynthesis L-glutamate L-alanine biosynthesis L-cysteine E2 ubiquitin- NT5C1A [+ 4 isozymes] 1D-myo-inositol isoform: PIK3CG hydrolase: hydroxy-7,9,11,13-tetraenoate PRPP L-selenocysteine biosynthesis diphthamide biosynthesis an [E2 ubiquitin- carboxypropyl)]- monophosphate pyrimidine deoxyribonucleosides degradation ENTPD1 5,6-dihydrothymine glutathione S a [thyroglobulin]- biosynthesis 1'5' (R)-mevalonate noradrenaline N- 4-phosphate 17S-H(p)DHA D-1 alpha biosynthesis biosynthesis biosynthesis biosynthesis β conjugating 37 Phe uridine nicotine-∆ β a 1-phosphatidyl- CTSD -D-fructose 2,6- conjugating wyosine in tRNA Cytosolic 5'- dehydrogenase: CTP -transferase: Kelch-like cholesterol 22- - L-thyroxine gln adenosine 2'-deoxyguanosine 2'-deoxyadenosine an L-histidine- 6 6 6 nitric-oxide nucleotidase: CANT1 dihydrothyminidase: b salutaridinol methyltransferase: a 1-phosphatidyl- phosphatidylinositol- 1D-myo-inositol synthase: ALOX15 hydroxylase, 15 epi-lipoxin A4 amidophosphoribosyltransferase: hydrogencarbonate met 3-phospho-D-glycerate spermidine bisphosphate N ,N ,N -trimethyl-L-lysine arg β enzyme: 7-(3-amino-3- nucleotidase IMPDH1 phosphorylase: UPP2 2'-deoxycytidine GSTA2 -iminium ion threohydrobupropion a 1-palmitoyl-2-acyl-sn- hydroxylase: CYP11A1 3,5,3'-triiodo- 2'-deoxyguanosine 2'-deoxyadenosine met S-adenosylmethionine -alanine enzyme]-S- h protein 7 4-phosphate 5- ser 2-oxoglutarate [translation 2-oxoglutarate pyruvate synthase: NOS3 nucleoside triphosphate nucleotidase: CANT1 DPYS PNMT phosphoinositide 1D-myo-inositol 5-phosphate mitochondrial: synthase: ALOX5 PPAT glu glu trimethyllysine UBE2W methylcarboxypropyl) 1A: NT5C1A uridine nicotine mevalonate kinase: MVK 17S-hydroperoxydocosahexaenoate L-thyronine kinase: DGUOK kinase: DGUOK 2-oxoglutaramate synthase: MAT2B MAT2A glutamate D-3-phosphoglycerate Deoxyhypusine carnosine ubiquitinyl- inosine-5'- glutathione S C 3-kinase glycero-3-phosphocholine kinase: PIP5K1A CYP27B1 S-adenosylmethionine glutamine γ-glutamyl elongation factor 2] glutamate alanine fructose- nitric oxide Tetrapyrrole Biosynthesis an N-terminal- phosphorylase: UPP1 diphosphohydrolase: nucleoside triphosphate 5'-α-carboxylmethylbutylhydroxychroman 3-phosphate (22R)-hydroxycholesterol 5-phospho-β- 2-oxo-4-methylthiobutanoate dehydrogenase: PHGDH synthase: DHPS fructose-2,6- dioxygenase: TMLHE synthase: L-cysteine -wyosine Cytosolic monophosphate 2'-deoxycytidine 3-(carbamoylamino)- -transferase: imine (R)-adrenaline gly glutamine-dependent S-adenosylmethionine dehydrogenase: dehydrogenase: aminotransferase: 6 6 ENTPD2 [ regulatory subunit phosphatidylinositol- phosphatidylinositol- 15 epi-lipoxin B4 adenosine purine- 2'-deoxyguanosine 2'-deoxyadenosine synthase: synthetase: seryl-tRNA kinase: (E)-(4-aminobutylidene) 6P, 2 3-hydroxy-N ,N ,N Rapoport-Luebering glycolytic shunt argininosuccinate synthase: NOS2 monoubiquitinyl- carboxycarbonylase: deaminase: CDA diphosphohydrolase: 2-methylpropanoate oxidase: phosphatidylinositol D-ribosylamine aminotransferase: KYAT1 a 2-[(3S)-3-amino- bisphosphatase: CARNS1 ubiquitin- purine 5'- dehydrogenase: uracil GSTA1 calcitriol L-thyroxine 15 epi-lipoxin A carbamoyl- synthetase: MAT1A GLUD2 3-phosphooxypyruvate GLUD2 GPT2 6 Sema E (R)-5-phosphomevalonate 4 kinase (ATP): DCK kinase (ATP): DCK MAT2B MAT2A synthetase, kinase: lyase: ASL [protein] ENTPD2 p87: PIK3R6 3,5-bisphosphate 5- 22-β-hydroxycholesterol 20- 4-phosphate 5- 5-phosphate 4- deaminase: ADA nucleoside:phosphate GLUL γ ALDH18A1 (3-aminopropyl)amine -trimethyl-L-lysine nitric-oxide carnosine heme biosynthesis HECT-type conjugating LCMT2 nucleotidase: IMPDH2 β GSTA2 AOX1 7-O- phosphatidylinositol- phosphate adenosine dGMP dAMP mitochondrial -L-glutamyl glutamate 3-carboxypropyl]-L- TIGAR GMP dihydropyrimidine thymidine UMP -ureidopropionase: phosphatidylinositol- α kinase: PIP5K1B kinase: PIP4K2A ribosyltransferase: PNP S-adenosylmethionine gln glutamate alanine PFKFB1 synthase: NOS1 heme a 2'-deoxyuridine hydroxybupropion acetylsalutaridinol phosphatidylinositol- phosphatase: SACM1L an N-palmitoyl- -hydroxylase: CYP11A1 phosphoribosylglycinamide 5-phosphate phosphoserine Deoxyhypusine histidine-[translation 3-hydroxy-N 6 ,N 13-DPG E3 ubiquitin enzyme wybutosine 37 NT5C2 CMP UPB1 phosphomevalonate 4-phosphate 5- 3-phosphate 5- synthase: CAD kinase: ADK precursor: dehydrogenase: dehydrogenase: aminotransferase: fructose-2,6- biosynthesis dehydrogenase: glutathione S cotinine synthetase: MAT1A 2-oxoglutarate 6 6 Phe thymidine purine ribonucleosides degradation to ribose-1-phosphate Cytosolic purine 5'- 4,5-bisphosphate phosphatidylinositol phosphatidylethanolamine phosphatidylinositol Phosphatidylinositol- (17S)-hydroxydocosahexaenoate ligase: GART adenine γ aminotransferase: PSAT1 synthase: DHPS elongation factor 2] fructose- ,N -trimethyl-L- transferase: E2 (E3- in tRNA [+ 3 isozymes] GMP 5'- XMP -transferase: α kinase: PMVK kinase: PIP5K1A kinase: PIKFYVE SARS2 -glutamyl GLUD1 GLUD1 GPT bisphosphatase: gly DPYD phosphorylase: Cytosolic purine 5'- -carboxyethylhydroxychroman 3-kinase: PIK3C2G (20R,22R)-dihydroxycholesterol 4 phosphate 5 5-phosphate 4- inosine phosphoribosyltransferase: dGMP dAMP 4-(methylsulfanyl)-2-oxobutanoate SAM a [deoxyhypusine Diphthine 6P, 2 NEDD4L independent) 2'-deoxyuridine nucleotidase: NT5C2 (R)-3-amino-2- LLT-1 3,5-bisphosphate 5- N-acylphosphatidylethanolamine- phosphate PFKFB1 lysine glycine bisphosphoglycerate L-arginino-succinate L-citrulline protoheme RING-type nucleotidase: nucleotidase: NT5C2 GSTA1 phosphatidylinositol- kinase: PIP5K1C kinase type-2 taurine biosynthesis II asp adenine APRT kinase: GUK1 kinase: AK5 SAM Seryl-tRNA glu synthase: glu ala kinase: 5-aminolevulinate phosphorylase: TYMP methylpropanoate (R)-mevalonate diphosphate phosphatidylinositol- phosphatase: FIG4 hydrolysing α β carbamoyl phosphate O-phospho-L-serine synthase]-N-(4- lyase: SHMT1 mutase: BPGM E3 ubiquitin : UBE2O NT5C2 XMP 5'- Cytosolic 5'-nucleotidase 5'-hydroxycotinine cotinine cotinine,NADPH:oxygen UDP- 4-phosphate 5- 20- -22- - (17S)- (17S)- taurine biosynthesis GAR reductase: fructose-2,6- heme o adenosine 5,6-dihydrouracil Cytosolic 5'-nucleotidase [+ 19 isozymes] 4,5-bisphosphate 1-phosphatidyl- [+ 3 isozymes] gamma: PIP4K2C inosine synthetase, aminobutylidene)-lysine DPH5 PFKFB3 homocarnosine synthase: ALAS2 a [HECT-type UPP2 adenosine 1A: NT5C1A synthetase: hydroxylase: oxidoreductase: CYP2A6 glucuronosyltransferase thebaine phospholipase: NAPEPLD dihydroxycholesterol side- AMP ALDH18A1 γ bisphosphatase: synthase: transferase: Cytosolic 5'- nucleotidase: thymine Spectrin beta kinase: PIP5K1B hydroxydocosahexaenoate hydroxydocosahexaenoate phosphorylase: cytoplasmic: -glutamyl 4-trimethylammoniobutanal 2,3-diphospho- E3 ubiquitin 1A: NT5C1A a glutathione- 3-kinase: PIK3C2B 1D-myo-inositol cys dGDP S-adenosylmethionine L3 phosphoserine Deoxyhypusine a diphthine-[translation fructose- biosynthesis 5-aminolevulinate RBX1 CUL1 tRNA-uridine 2-thiolation (cytoplasmic) NT5C2 dihydropyrimidinase: 2'-deoxyuridine [+ 2 isozymes] CYP2A6 CYP2A6 [+ 4 isozymes] cotinine 2B11 precursor, diphosphomevalonate phosphatidylinositol chain lyase: CYP11A1 a 1-phosphatidyl- 7-lipoxygenase: ALOX5 4-lipoxygenase: ALOX5 phosphoribosylglycinamide aspartate dADP L-glutamate-5- kinase: PFKFB3 D-glycerate COX10 adenosine nucleotidase [+ 2 isozymes] S-conjugate cotinine N-oxide nicotine degradation IV chain, non- palmitoyl ethanolamide PNP 1,2-dihydroxy-3-keto- SARS1 phosphatase: VPS29 6P, 2 synthase: ALAS1 transferase]- phosphorylase: adenosine microsomal: UGT2B11 decarboxylase: MVD phosphatidylinositol- 3,5-bisphosphate cys formyltransferase: GART decarboxylase synthase: DHPS elongation factor 2] ferroheme o SKP1 SKP2 1A: NT5C1A Cytosolic DPYS uridine [+ 4 isozymes] [+ 4 isozymes] methonium ion erythrocytic 1 4 phosphate 5 1D-myo-inositol phosphopantothenate- carbamoyltransferase: 5-methylthiopentene selenide semialdehyde ALDH18A1 fructose-2,6- 4-trimethylaminobutyraldehyde argininosuccinate 5-aminolevulinate S-ubiquitinyl- deaminase: deaminase: 4-phosphate 3- pregnenolone an L-seryl- L-3-phosphoserine kinase: 4-aminobutanoate TYMP cytidine trans-3'- cotinine (7S,17S)-17-hydroxy-7- (4S,17S)-17-hydroxy-4- nucleoside nucleoside an [eIF5A- ADA purine 5'- kinase: PIP5K1C 4,5-bisphosphate (R)-4'- -cysteine ligase: PPCS CAD sec γ bisphosphatase: dehydrogenase: ALDH9A1 2,3- synthase: ASS1 RING-type [+ 2 isozymes] cysteine hypoxanthine SAH 1,2-dihydroxy-5-dioxygenase: ADI1 [tRNA ] -L-glutamyl phosphatase: PSPH diphthine--ammonia PFKFB4 2,3-bisphosphoglycerate- homocarnosine heme a L-cysteine cys 3-ureidopropanoate deoxyuridine ADA N'-hydroxymethyl- hydroxycotinine glucuronosyltransferase: (S)-nicotine IPP kinase: PIK3C2A hydroperoxydocosahexaenoate hydroperoxydocosahexaenoate FGAR diphosphate diphosphate dAdoMet Selenide precursor]-N-(4- PFKFB4 bisphosphoglycerate 3- porphobilinogen E3 ubiquitin nucleotidase: 5'-hydroxycotinine 2+ Sodium/ 2+ [+ 3 isozymes] 1-phosphatidylinositol- phosphopantothenoyl- 5-phosphate ligase: DPH6 synthase: Ca Ca dioxygenase: (methylsulfanyl)pent-1-en-3-one aminobutylidene)-lysine L-aspartate fructose- dependent synthase: phosphorylase: a glutathione- norcotinine UDP- UGT1A4 neopinone oripavine Phosphoinositide 4,5-bisphosphate (17S)- (17S)- L-cysteine kinase: NME4 kinase: NME4 water L-seryl- γ-butyrobetaine phosphatase: MINPP1 synthase: ALAD transferase: inosine guanosine NT5C2 potassium/ phosphoribosylformylglycinamidine pyrimidine deoxyribonucleotides ser a diphthamide- biosynthesis fructose-2,6- phosphoglycerate CARNS1 COX15 cysteine β-ureidopropionase: xanthosine adenosine inosine guanosine isopentenyl-diphosphate 3-kinase regulatory CDO1 dikinase: γ-glutamyl 6P, 2 HECT-type UPP1 S-conjugate Cytochrome glucuronosyltransferase hydroxydocosahexaenoate hydroxydocosahexaenoate N-carbamoyl-L-aspartate dGDP kinase: dADP kinase: tRNA(Sec) Deoxyhypusine MARCHF6 Cytosolic 5'- nicotine nicotine a heme hHRG-1calcium a heme phosphodiesterase: biosynthesis from CTP adenosylhomocysteinase: spermidine (S)-1-pyrroline- bisphosphatase: mutase: BPGM desulfurase: UDP + + delta-isomerase: IDI2 synthase: PFAS hypoxanthine putrescine [translation homocarnosine UPB1 enolase-phosphatase: SEPHS2 phosphate kinase: γ-butyrobetaine porphobilinogen E3 ubiquitin glutathioneS P450 4X1: 2B11 precursor, cotinine- Li Li subunit 5: PIK3R5 PLCD1 7-lipoxygenase: ALOX5 4-lipoxygenase: ALOX5 3-sulfino-L-alanine NME1 NME2 NME1 NME2 AHCY spermidine synthase: SRM kinase: 5-carboxylate serine synthase: DHPS PFKFB2 2-phospho- ferroheme i RING-type NFS1 inosine guanosine nucleotidase purine deoxyribonucleosides degradation hydroxylase: monooxygenase: glu exchanger 6 isopentenyl-diphosphate pregnenolone phosphoribosyltransferase: reductase: elongation factor 2] oxaloacetate transferase: microsomal: UGT2B11 CTP [+ 5 isozymes] [+ 5 isozymes] ENOPH1 [+ 2 isozymes] PSTK PFKFB2 dioxygenase: BBOX1 D-glycerate an [L-cysteine phosphorylase: phosphorylase: 1A: NT5C1A -conjugate 4-oxo-4-(3- CYP4X1 glucuronide CYP2A6 FMO3 7,8-epoxy-17S-hydroxy- 4(5)-epoxy-17S-hydroxy- asp hydroxymethyltransferase: aspartate a [protein]- E3 ubiquitin 2B1 delta-isomerase: IDI1 a 1-phosphatidyl- 1-phosphatidylinositol- FGAM dihydroorotase: CAD HPRT1 pyrroline-5- ALDH18A1 an [eIF5A-precursor]- protein citrullination 3-phospho- porphobilinogen heme a NEDD4L β-alanine xanthosine purine- inosine guanosine γ trans-3- CD235b π desulfurase]-S- PNP PNP [+ 2 isozymes] -glutamate pyridyl)-N- [+ 2 isozymes] (S)-nornicotine mic α 4,5-bisphosphate docosahexaenoate docosahexaenoate cysteamine nucleotidase: CANT1 ser an O-phospho-L- carboxylate SHMT1 deoxyhypusine aminotransferase: N -phospho- transferase: phosphorylase: nucleoside:phosphate phosphorylase: phosphorylase: hydroxycotinine- [+ 4 isozymes] [+ 5 isozymes] codeinone morphinone 1D-myo-inositol a 1-phosphatidyl- pregnenolone 3- pregnenolone 17- - selenophosphate F6P L-carnitine D-glycerate deaminase: HMBS synthase: hydrolase cysteine guanosine dGTP dATP L-homocysteine 2-hydroxy-5-(methylsulfanyl)- Sec L-glutamate-5- sulfanyl-L-cysteine methylbutanamide DMAPP phosphodiesterase: phosphoribosylaminoimidazole CTP triphosphatase: seryl-[tRNA ] reductase: serine deoxyhypusine GOT1L1 L-histidine UBR1 uracil 2-deoxy-α-D- PNP ribosyltransferase: PNP PNP PNP 2'-deoxyadenosine norcotinine glucuronide nic 3,4-bisphosphate 1D-myo-inositol dehydrogenase: HSD3B1 hydroxylase: CYP17A1 cysteamine S-methyl-5'-thioadenosine semialdehyde a [protein]- COX15 cysteine Growth PLCG2 sulfinic acid synthetase: GART (S)-dihydroorotate NTPCR 3-oxopent-1-enyl 1-phosphate PYCR1 hydroxymethyltransferase: hydroxylase: [+ 4 isozymes] hypoxanthine guanine xanthosine ribose 1-phosphate glutathione- nicotine- glu 4,5-bisphosphate phosphatidylinositol- pregnenolone 3- dioxygenase: IMP 5'-methylthioadenosine L-arginine aspartate preuroporphyrinogen 2'-hydroxynicotine decarboxylase: guanosine peptidylarginine desulfurase:TUM1 S-conjugate 1'-N-oxide factor dimethylallyltransferase: O-phosphoseryl- pyrroline 5- ornithine SHMT2 DOHH aminotransferase: hydroxyferroheme i α-D-ribose- adenosine UGT 3,5-bisphosphate dehydrogenase: HSD3B2 α 1-phosphatidylinositol- L-cysteate ADO AIR dihydroorotate phosphorylase: CDP cystathionine β- phosphorylase: MTAP uracil degradation sulfurtransferase: γ receptor- GGPS1 17- -hydroxypregnenolone CSAD enolase-phosphatase: aminotransferase: deiminase: PADI6 uroporphyrinogen- 1-phosphate deaminase: -glutamate 1-phosphatidylinositol- phosphatidylinositol- 4,5-bisphosphate tRNA(Sec) carboxylate I (reductive) GOT1 norcotinine 3-phosphatase: resolvin D2 resolvin D1 resolvin D4 resolvin D3 dehydrogenase: PNP synthase: CBS MPST guanine dimethylallyltransferase: codeine Ribonucleoside- ENOPH1 gly an [eIF5A]-hypusine peptidylarginine hypoxanthine xanthosine hydrolase: bound 4,5-bisphosphate hypotaurine selenium reductase: OAT III synthase: UROS ADA 4-oxo-4- nicotine- 4,5-bisphosphate MTMR14 17-α-hydroxypregnenolone phosphodiesterase: phosphoribosylaminoimidazole DHODH inosine-5'- adenylosuccinate asp a ubiquitin- a [3-mercaptopyruvate deaminase: phosphodeoxyribomutase: protein 14 FDPS pregn-5-ene-3,20-dione diphosphate uracil deiminase: PADI4 dehydrogenase: phosphorylase: GGT5 (3-pyridyl)- glucuronide 3-kinase: PLCE1 hypotaurine dTMP de novo biosynthesis (mitochondrial) transferase: PYCR2 phosphodiesterase: carboxylase: PAICS PRPP synthetase: ADSS1 6 related modifier 1 sulfurtransferase]-S PGM2 phosphatidylinositol- 17,20-lyase: CYP17A1 guanine monophosphate reductase subunit L-ornithine dihydropyrimidine uroporphyrinogen-III a [protein]-N - XDH GDA PNP an (L- pseudooxynicotine PLCD1 PIK3R6 PIK3CG phosphatidylinositol- orotate L-cystathionine SEPSECS peptidylarginine -sulfanyl-L-cysteine 2'-deoxyinosine 2'-deoxyguanosine butanamide Olfactory geranyl diphosphate 3,5-bisphosphate 3- progesterone 1-phosphatidylinositol- dehydrogenase: adenylosuccinate M2 B: RRM2B RRM1 5-(methylsulfanyl)-2,3-dioxopentyl 1-phosphate 5-MTR-1-P dehydrogenase: DPYD ferroheme a monoubiquitinyl- URM1 D-ribose 5- cysteinylglycine) phosphatidylinositol β asp pro deiminase: PADI3 4-oxo-4- 1-phosphatidylinositol- phosphatidylinositol- 5-phosphate 4- phosphatase: MTMR3 isomerase: HSD3B1 3- -hydroxyandrost-5-en-17-one 4,5-bisphosphate CAIR IMPDH1 synthetase: ADSS2 a 7,8-dihydrofolate methylthioribose-1- uroporphyrinogen TUM1:MOCS3 phosphate -S-conjugate receptor 4,5-bisphosphate 4- Orotidine 5'- CDP reductase: L-lysine adenylyltransferase: (3-pyridyl)- ω,E,E-farnesyl diphosphate kinase: PIP4K2A dihydrofolate methylthioribulose phosphate isomerase: MRI1 an L- 5,6-dihydrouracil peptidylarginine decarboxylase: sulfurtransferase: xanthine 2A5 4,5-bisphosphate 4,5-bisphosphate progesterone phosphodiesterase: aspirin triggered resolvin D biosynthesis taurine inosine-5'- MOCS3 morphine phosphatase: PIP4P1 DHA dehydrogenase: phosphate RRM1 RRM2 cystathionine 1-phosphate selenocysteinyl- deiminase: PADI1 Aminopeptidase butanamide synthase: GGPS1 phosphodiesterase: 3-kinase: PLCB2 reductase: UROD MOCS3 deoxyinosine deoxyguanosine Phosphatidylinositol- isomerase: HSD3B2 phosphoribosylaminoimidazole- monophosphate γ sec a carboxy- 4-oxo-4-(3- phosphatidylinositol HSD3B1 decarboxylase: UMPS adenylo-succinate -lyase: CTH dehydratase: APIP [tRNA ] dihydropyrimidinase: peptidylarginine xanthine phosphorylase: phosphorylase: N: ANPEP 4-oxo-4-(pyridin- ω,E,E-farnesyl diphosphate PLCG2 PIK3R5 PIK3CG 5-phosphate 4- a [glycerolipid]- taurine dCDP DHFR2 adenylated-[ubiquitin- a [MOCS3]-S- Sodium- 1-phosphatidylinositol- succinocarboxamide guanine dehydrogenase: DPYS 34 dehydrogenase: pyridyl)-butanoate 4,5-bisphosphate 4- DHA dehydrogenase: deiminase: PADI2 coproporphyrinogen III a carboxymethyluridine PNP PNP 3-yl)butanal synthase: FDPS kinase type-2 progesterone (4Z,7Z,10Z,13Z,16Z,19Z) thymidylate glycine biosynthesis L-methionine salvage from L-homocysteine a [protein]- mRNA capping II related modifier 1] sulfanylcysteine an L-cysteine- and chloride- 1-phosphatidylinositol- phosphatidylinositol- 4,5-bisphosphate synthase: PAICS phosphoribosyltransferase: IMPDH2 adenylosuccinate (2Z)-2-aminobut- cytochrome in tRNA XDH phosphatase: PIP4P2 HSD3B2 -docosahexaenoate orotidine 5'-phosphate nucleoside nucleoside L-citrulline taurine dependent taurine 4,5-bisphosphate 4,5-bisphosphate gamma: PIP4K2C phosphodiesterase: HPRT1 synthase: cys 3-ureidopropanoate S-conjugate lyase: ADSL 2-enoate coproporphyrinogen- c biogenesis α (2E,6E)-farnesyl diphosphate diphosphate S-methyl-5-thio-D-ribulose 1-phosphate L-tyrosine tRNA 2-deoxy- -D- taurine phosphodiesterase: 3-kinase: progesterone 21- progesterone 17- 5-androstene-3,17-dione PLCB1 C20 prostanoid biosynthesis diphosphate TYMS a 5'-triphospho- URM1 urate a 5,10- glyoxylate biosynthesis L-homocysteine III oxidase: CPOX 34 ribose 1-phosphate SAICAR kinase: NME4 phosphohydrolase: a tetrahydrofolate L-asparagine β (carboxymethyluridine - sulfurtransferase: 4-hydroxy-4-(3- transporter PLCE1 PIK3R3 PIK3CB hydroxylase: CYP21A2 hydroxylase: CYP17A1 [+ 9 isozymes] Orotidine 5'- XMP AMP alanine--glyoxylate -ureidopropionase: protoheme ribonucleotide-[mRNA] RGS21 farnesyltranstransferase: methylenetetrahydrofolate biosynthesis betaine-- S-methylmethionine mRNA 5-O)-methyltransferase: cysteine-S- kynurenine-- androstenedione dCDP kinase: ENTPD4 methionine UPB1 MOCS3 pyridyl)-butanoate 4-oxo-4-(3- 1-phosphatidylinositol- phosphatidylinositol- (4Z,7Z,10Z,13Z,16Z,19Z) arachidonate adenylosuccinate phosphate aminotransferase: homocysteine S- homocysteine protoporphyrinogen IX holocytochrome-c triphosphatase: conjugate N- GGPS1 isomerase: HSD3B1 Ins(1,4,5)P AMP kinase: AK5 NME1 NME2 [+ 3 isozymes] phe synthase: ALKBH8 TRMT112 oxoglutarate carbon disulfide pyridyl)-butanoate 4,5-bisphosphate 3 decarboxylase: UMPS AGXT2 synthase: HCCS 4,5-bisphosphate 11-deoxycorticosterone 17-α-hydroxyprogesterone -docosahexaenoate lyase: ADSL 2-iminobutanoate phenylalanine methyltransferase: methyltransferase: RNGTT a 5-(2-methoxy- a thiocarboxylated- acetyltransferase: transaminase: a 1-phosphatidyl- androstenedione asp MTR β a diphospho-5'- oxidation III (metazoa) Olfactory phosphodiesterase: 3-kinase: prostaglandin G/H [+ 6 isozymes] [+ 5 isozymes] -alanine protoporphyrinogen a c-type NAT8 GGPP 17R- UMP GMP synthase: dCMP serine--pyruvate hydroxylase: asparagine BHMT BHMT2 ribonucleotide-[mRNA] 2-oxoethyl) [ubiquitin-related KYAT3 1D-myo-inositol isomerase: HSD3B2 oxidase: PPOX receptor PLCB2 PIK3R1 PIK3CA synthase: PTGS1 AICAR cytochrome 34 17-hydroxyprogesterone hydroperoxy GMPS aminotransferase: PAH met uridine in tRNA modifier 1] 4-(3-pyridyl) 5-phosphate UMP-CMP ADP dCTP synthetase: cysteine carbon disulfide 52K1 prostaglandin G/H deoxycytidylate serine mRNA 4-hydroxy-4-(3- 1-phosphatidylinositol- phosphatidylinositol- 21-hydroxylase: CYP21A2 androst-4-ene-3,17-dione DHA synthase: AGXT tyr ASNS protoporphyrin IX conjugate -3-butenoate superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism synthase: PTGS2 aminoimidazole kinase: CMPK2 hydroxymethyltransferase: guanylyltransferase: a mercapturate 4,5-bisphosphate 4,5-bisphosphate PTGS2 ADP reductase: deaminase: DCTD tRNA-5-(2-methoxy- β carbonyl sulfide pyridyl)-butanoate Starch- carboxamide UMP kinase: CMPK1 SHMT2 ammonium gly asn RNGTT -lyase: 3-kinase: 11-deoxycorticosterone 11-desoxycortisol RRM1 RRM2 2-oxoethyl)uridine monooxygenase: binding phosphodiesterase: β (17R)- prostaglandin H dUMP ferrochelatase: KYAT1 androstenedione 17 - cytochrome P450 2 ribonucleotide a 5'-(5'-triphosphoguanosine) Ins(1,4,5)P PLCB1 PIK3R2 PIK3CD UDP Ribonucleoside- 2-sulfurtransferase: CYP2E1 domain- 3 hydroxydocosahexaenoate FECH 11-deoxycorticosterone reductase: HSD17B3 2A6: CYP2A6 formyltransferase: thymidylate -(nucleotide)-[mRNA] 4-(3-pyridyl) [+ 3 isozymes] diphosphate CTU2 CTU1 containing [+ 9 isozymes] 11β-hydroxylase: CYP11B1 ATIC synthase: TYMS sulfinylidenemethanethione androstenedione androstenedione guanine-N7 2-aminoprop- -butanoate 4-(3-pyridyl) prostacyclin prostaglandin-H2 D- prostaglandin E thromboxane-A GMP reductase protoheme a thiol protein 1 inositol 1,4,5- 11-deoxycorticosterone (17R)- (17R)- -3-butenoate inositol-1,4,5- 1-phosphatidyl- reductase: AKR1C3 hydroxylase: CYP19A1 synthase: PTGIS isomerase: PTGDS synthase: PTGES2 synthase: TBXAS1 subunit M2 B: dTMP methyltransferase: a 5-(2-methoxy- 2-enoate 11β-hydroxylase: CYP11B2 11-desoxycortisol hydroxydocosahexaenoate hydroxydocosahexaenoate FAICAR glutaminyl-tRNA gln Aminoacyl-tRNA Charging trisphosphate trisphosphate Ins(1,4,5)P 1D-myo- RNMT 2-oxoethyl)2- 3 prostaglandin D prostaglandin E RRM2B RRM1 7-lipoxygenase: ALOX5 4-lipoxygenase: ALOX5 GMP kinase: thymidylate biosynthesis via transamidation 7 34 5-phosphatase: 3-kinase: IPMK inositol 3,4,5- IMP UDP kinase: UDP reductase: a 5'-(N -methyl 5'- thiouridine in tRNA IL-27B corticosterone 11-deoxycortisol 11β- testosterone 19-hydroxyandrostenedione prostaglandin I synthase: HPGDS synthase: PTGES3 thromboxane A kinase: DTYMK 2 2 GUK1 triphosphoguanosine)- SYNJ1 inositol-1,3,4,5- 1-D-myo- inositol 1,4,5- trisphosphate cyclohydrolase: NME1 NME2 RRM1 RRM2 3-pyridylacetate hydroxylase: CYP11B1 (7S,17R)-17-hydroxy-7- (4S,17R)-17-hydroxy-4- prostaglandin E monothiocarbonate 4-(3-pyridyl) tetrakisphosphate 3- inositol-1,4,5- trisphosphate cytochrome P450 ATIC nucleoside dADP dTDP glu (ribonucleotide)-[mRNA] 2-iminopropanoate inositol-1,4,5- Cytochrome P450 11B2, gln α hydroperoxydocosahexaenoate hydroperoxydocosahexaenoate prostaglandin D synthase: PTGES Ribonucleoside- GDP mRNA -butanoate phosphatase: PTEN trisphosphate 3-kinase: IPMK testosterone 5 - cytochrome P450 2A6: CYP2A6 2 diphosphate trisphosphate mitochondrial: CYP11B2 cortisol diphosphate dTDP kinase: (17R)- Cadherin-10 reductase: SRD5A1 2A6: CYP2A6 (17R)- kinase: NME4 nucleoside (nucleoside-2'-O)- Arg/N-end rule pathway (eukaryotic) 5-phosphatase: inositol-1,3,4,5- 3-kinase: ITPKB inositol-1,3,4,5- 1-D-myo- 19-hydroxyandrostenedione IMP reductase subunit GDP kinase: NME1 NME2 glutaminase: α hydroxydocosahexaenoate hydroxydocosahexaenoate prostaglandin E diphosphate methyltransferase: INPP5B tetrakisphosphate 3- inositol-1,4,5- 18-hydroxycorticosterone testosterone 5 - testosterone 19- 19-hydrogenase: CYP19A1 2 [+ 5 isozymes] NME1 NME2 GLS tetrakisphosphate 1-D-myo-inositol- 7-lipoxygenase: ALOX5 4-lipoxygenase: ALOX5 M2 B: RRM2B RRM1 nucleoside an N-terminal- an N-terminal- an N-terminal- reductase: SRD5A2 hydroxylase: CYP19A1 kinase: NME4 CMTR1 3-phosphatase: trisphosphate phosphatase: PTEN trisphosphate 4,5-epoxy- nucleoside diphosphate asparagine a 5'-(N 7 -methyl 5'- D-myo- 19-oxoandrostenedione 7(8)-epoxy- an L-glutamyl- L-methionyl- L-methionyl- L-methionyl-L- pyruvate carbonyl sulfide hydrogen sulfide 3-pyridylacetate MINPP1 3-kinase: ITPKA 3-kinase: ITPKB 18-hydroxycorticosterone myo-inositol dADP kinase: tNOX inositol (1,4,5)- inositol-1,3,4,5- 17R-hydroxy- 17R-hydroxy- diphosphate kinase: NME4 synthetase: Gln triphosphoguanosine)-(2'-O- L-asparaginyl- L-glutaminyl- cysteinyl-[protein] 18-methyl oxidase: CYP11B2 biosynthesis NME1 NME2 [tRNA ] trisphosphate inositol 1,4,5- tetrakisphosphate 1-D-myo-inositol- 17-β-hydroxy-5-α-androstan-3-one 19-hydroxytestosterone cytochrome P450 docosahexaenoate docosahexaenoate kinase: NME4 ASNS methyl-ribonucleotide)-[mRNA] inosine-5'- [+ 5 isozymes] [protein] [protein] methionine gln [+ 5 isozymes] 5-phosphatase: trisphosphate 3-phosphatase: trisphosphate 2A6: CYP2A6 D-glucopyranose [+ 5 isozymes] glutaminase: Glutamyl-tRNA(Gln) N-terminal N-terminal aminopeptidase: aldosterone monophosphate UTP dTTP OCRL 3-kinase: ITPKC MINPP1 3-kinase: ITPKA cytochrome P450 6-phosphate dUDP amidotransferase methionine N - methionine N - 19-oxoandrostenedione inositol-3- dehydrogenase: GLS2 α α METAP2 β Fatty Acid and Lipid Degradation RGS12 2A6: CYP2A6 dATP subunit A valproate -oxidation β 7 acetyltransferase: acetyltransferase: 3-phosphoinositide degradation mitochondrial L- triacylglycerol degradation α acetone degradation III (to propane-1,2-diol) anandamide lipoxygenation inositol-1,4,5- inositol 1,4,5- 2- hydroxylase: CYP19A1 phosphate IMPDH1 CTP synthase: nucleoside GTP CTP a 5'-(N -methyl 5'- methionine 2-methyl-branched fatty acid -oxidation III Alcohol Degradation D-myo-inositol 19-hydroxytestosterone 19- homolog: QRSL1 NAA25 NAA20 NAA25 NAA20 trisphosphate trisphosphate aspirin triggered aspirin triggered aspirin triggered aspirin triggered synthase: CTPS1 synthase: triphosphoguanosine)-(2'-O- aminopeptidase: carnitine shuttle fatty acid β-oxidation (1,3,4,5)- estrone inosine-5'- diphosphate an N-terminal- an N-terminal 1-phosphatidyl- dehydrogenase: CYP19A1 Probable glutamyl- α α valproate 5-phosphatase: 3-kinase: ITPKC resolvin D2 resolvin D1 resolvin D4 resolvin D3 ISYNA1 kinase: NME4 guanosine nucleotides CTPS1 methyl-ribonucleotide)-[mRNA] METAP1 a triacyl-sn-glycerol propan-2-ol anandamide monophosphate CTP synthase: N -acetyl-L- N -acetyl-L- a long-chain a 2-methyl branched a phytoceramide Olfactory tetrakisphosphate tRNA(Gln) valproyl- 1D-myo-inositol ethanol degradation III SYNJ2 D-myo-inositol de novo biosynthesis superpathway of pyrimidine deoxyribonucleoside salvage mRNA acetoacetate ethanol receptor 19-oxo-testosterone Ins(3)P dehydrogenase: CTPS2 dUDP kinase: CTP methionyl-L- methionyl-L- an N-terminal L- 3,4,5-trisphosphate fatty acyl-CoA 2,3,4-saturated fatty acid ethanol inositol-1,3,4,5- (1,3,4,5)- amidotransferase (nucleoside-2'-O)- coenzyme A carnitine O 2-methyl hormone-sensitive fatty acid 2- (S)-reticuline biosynthesis estrone 17β- synthase: asparaginyl- glutaminyl- degradation IV 4F3/4F16/ inositol-(1,4,5)- tetrakisphosphate IMPDH2 NME1 NME2 cysteinyl-[protein] synthetase: propan-2-ol:NADP+ anandamide 5- anandamide 12- degradation II tetrakisphosphate 2'-deoxycytidine subunit B, methyltransferase acetyltransferase: branched lipase: LIPE hydroxylase: sphingosine and sphingosine- anandamide ethanol 4F29 trisphosphate reductase: HSD17B3 myo-inositol- CTP [+ 5 isozymes] pyrimidine CTPS2 [protein] [protein] Phosphatidylinositol- phosphatidylinositol- oxidoreductase: 5-phosphatase: IMP mitochondrial: GATB 2: CMTR2 ACSM1 CPT2 medium-chain triacylglycerol FA2H 1-phosphate metabolism acetoacetate lipoxygenase: lipoxygenase: (15S)- ethanol 5-phosphatase: inositol-1,3,4,5- cytochrome P450 estradiol-17β:NAD(P)+ 17- 3-phosphate ribonucleosides salvage I [+ 4 isozymes] N -acetyl-L- N -acetyl-L- 3,4,5-trisphosphate 5- ethanol ethanol INPP5D 7 α α valproyl-CoA 3,4,5-trisphosphate ADH1B decarboxylase ALOX5 ALOX12 tetrakisphosphate tyr 2A6: CYP2A6 serotonin and nucleotidase: CANT1 dUTP 2'-deoxycytidine 2'-deoxycytidine a 5-phosphooxy- a 5'-(N -methyl 5'- carnitine O- acyl-coenzyme lipase: PNLIP lipoxygenase: monooxygenase: Endogenous INPP5A oxidoreductase: HSD17B7 monophosphatase: methionine- methionine- phosphatase: INPP5E a (2'R)-2'-hydroxy- a sphingosine ethanol:NAD+ alcohol leukotriene biosynthesis inosine-5'- L-glutamyl- triphosphoguanosine)-(2'-O- 3-phosphatase ALOX15 retrovirus inositol-1,3,4,5- 5-phosphatase: 19-oxotestosterone 2- melatonin biosynthesis CTP triphosphatase: cytidine deaminase: CDA kinase: DCK ammonium tRNA charging an N-terminal palmitoyltransferase: A synthetase: [+ 12 isozymes] phytoceramide CYP2E1 peroxidase: CAT [+ 4 isozymes] [+ 2 isozymes] IMPA2 deoxyuridine Gln peptidase: peptidase: valproyl-CoA TPTE2: TPTE2 ceramide oxidoreductase: tetrakisphosphate β XMP NTPCR monophosphate [tRNA ] methyl-ribonucleotide)-(2'-O- 3-sulfeno-L- phosphatidylinositol- CPT1B ACSM1 fatty acid β-oxidation (5S)-5- (12S)- group K INPP5D hydroxylase: CYP19A1 APEH APEH dehydrogenase: acetone CYTOCHROME ADH1B acetaldehyde tyrosinase: myo-inositol- 5'-triphosphate dehydrogenase: methyl-ribonucleotide)-[mRNA] phosphatidylinositol- 3,4,5-trisphosphate 5- a 1,2-diacyl-sn-glycerol ceramidase: ceramidase: hydroperoxyanandamide hydroperoxyandamide (15S)- member 10 Gag 5-phosphatase: inositol-1,3,4,5- arachidonate cytidine 2'-deoxyuridine dCMP an N-terminal an N-terminal alanyl-[protein] (unsaturated, P450 2: CYP2G1P acetaldehyde trp CDP nucleotidohydrolase: ACADSB carnitine:fatty 2-methyl INPPL1 TYR 3-phosphate GMP IMPDH1 Glutamyl-tRNA(Gln) Ile His asp Cys Tyr Trp Arg Met 3,4,5-trisphosphate 3- phosphatase: INPPL1 ASAH2 ACER2 hydroperoxyanandamide polyprotein Ins(1,4)P tetrakisphosphate deaminase: CDA ile a tRNA his a tRNA tRNA asp cys a tRNA tyr a tRNA trp a tRNA arg a tRNA elongator tRNA met L-asparaginyl- L-glutaminyl- (2E)-2- odd number) cytochrome P450 acetaldehyde acetaldehyde 2 tryptophan 5- DUT UMP-CMP acyl CoA branched diacylglycerol sn- monophosphatase: synthase: amidotransferase Ala glu ser Leu Asn Pro phosphatase: PTEN phosphatidylinositol- a (2R)-2-hydroxy even [+ 4 isozymes] inositol-1,3,4,5- arachidonate 5- Ribonucleoside- CMP inosine-5'- thymidine a tRNA ala glu a tRNA ser a tRNA leu a tRNA asn tRNA pro a tRNA [protein] [protein] propylpent- a (3Z)-alk-3- 2A6: CYP2A6 acetaldehyde dehydrogenase: 5-phosphatase: p-tyramine hydroxylase: IMPA1 [+ 3 isozymes] kinase: acyltransferase: fatty acid-CoA 1 acylhydrolase: numbered straight chain GMPS diphosphate uridine subunit A Lys Val Phe Thr 3,4,5-trisphosphate 5- acetaldehyde inositol 1,4- tetrakisphosphate 5- INPPL1 lipoxygenase: ALOX5 TPH1 asp monophosphate kinase: TK1 lys a tRNA val a tRNA phe a tRNA thr a tRNA protein N-terminal protein N-terminal an N-terminal 2-enoyl-CoA CPT1A enoyl-CoA sphingosine acetone dehydrogenase: ALDH2 L-dopa CMPK2 homolog: QRSL1 a 1-phosphatidyl- ligase: SLC27A2 DAGLB cis3,trans2- 2,3,4-saturated fatty acid (5S)-5- (12S)- DEGA bisphosphate 1- phosphatase: SYNJ1 reductase subunit dUMP dehydrogenase: Isoleucyl-tRNA Probable histidyl- Aspartyl-tRNA Probable cysteinyl- Tyrosyl-tRNA Tryptophanyl- Probable arginyl- Methionyl-tRNA phosphatase: SYNJ1 monooxygenase: dehydrogenase: ALDH2 inositol-1,3,4,5- myo-inositol uridine-cytidine thymidine thymidine asparagine glutamine 3-sulfino-L- (2E)- 1D-myo-inositol acetaldehyde (5S)-HPETE tryptophan 5- GMP M2 B: RRM2B RRM1 dCMP kinase: synthetase, tRNA synthetase, synthetase, tRNA synthetase, synthetase, tRNA synthetase, tRNA synthetase, synthetase, carnitine O- [+ 3 isozymes] diacylglycerol sn- enoyl-CoA fatty acid-CoA hydroxyanandamide hydroxyandamide (15S)- ALDH2 phosphatase: adenylosuccinate IMPDH2 kinase: TK2 Probable glutamyl- Alanyl-tRNA synthetase, Probable glutamyl- seryl-tRNA synthetase, gly Gly Leucyl-tRNA synthetase, Probable asparaginyl- Probable prolyl- gln Gln amidohydrolase: amidohydrolase: alanyl-[protein] propylpent- phosphatidylinositol- a 2-methyl branched 2,3,4- Sphingosine- CYP2E1 acetaldehyde inositol-1,3,4,5- tetrakisphosphate 5- hydroxylase: thymidylate kinase: UCKL1 a tRNA a tRNA 4,5-bisphosphate palmitoyltransferase: isomerase: dehydrogenase: CMPK1 mitochondrial: HARS2 mitochondrial: CARS2 mitochondrial: MARS2 Met 1 acylhydrolase: ligase: SLC27A2 hydroxyanandamide INPP1 synthetase: ADSS1 CDP reductase: tRNA(Gln) lysyl-tRNA cytoplasmic: IARS1 cytoplasmic: AARS1 tRNA synthetase, mitochondrial mitochondrial: DARS2 cytoplasmic: LARS1 valyl tRNA tRNA synthetase, mitochondrial: YARS2 cytoplasmic: WARS1 Phenylalanyl- mitochondrial: RARS2 tRNA synthetase, Probable threonyl- initiator tRNA met NTAN1 NTAQ1 2-enoyl-CoA 3,4,5-trisphosphate 5- saturated fatty acyl-CoA 1-phosphate Sphingosine [+ 3 isozymes] acetaldehyde dehydrogenase: tetrakisphosphate phosphatase: SYNJ1 β synthase: TYMS uridine kinase: UCK1 CPT1C ECI1 ALDH3A2 Chromodomain- 17 -estradiol arachidonate 5- TPH2 adenine and thymidine mitochondrial: EARS2 precursor: SARS2 mitochondrial: NARS2 mitochondrial: PARS2 DAGLA [+ 3 isozymes] dopamine 5-hydroxy- RRM1 RRM2 XMP dUMP dCDP amidotransferase synthetase: KARS1 Isoleucyl-tRNA Probable alanyl- Histidyl-tRNA Aspartyl-tRNA Probable leucyl- Cysteinyl-tRNA synthetase: VARS2 Tyrosyl-tRNA Tryptophanyl- tRNA synthetase, Arginyl-tRNA Methionyl-tRNA tRNA synthetase 2, arginyl-tRNA- hydratase: phosphatidylinositol phosphatase: INPP5B an O-(long-chain- 2-methyl branched phosphatase kinase dehydrogenase: ALDH3A2 helicase- 5-phosphatase: inositol-1,3,4,5- lipoxygenase: ALOX5 GMP kinase: adenylosuccinate uridine kinase: UCK2 kinase: TK1 an N-terminal L- an N-terminal L- a (R)-2-hydroxy even Ins(4)P dTMP adenosine salvage III synthetase, synthetase, synthetase, tRNA synthetase, synthetase, synthetase, tRNA synthetase, mitochondrial: FARS2 synthetase, synthetase, cytoplasmic: TARS3 acyl)-L-carnitine hormone-sensitive 3,2-trans- hydroxyacetone ALDH3A2 acetate INPP5B 3-(3,4-dihydroxyphenyl) L-tryptophan GUK1 synthetase: ADSS2 dCDP subunit B, lysyl tRNA tRNA synthetase, Prolyl-tRNA Seryl-tRNA synthetase, Glycyl-tRNA Valyl-tRNA asparaginyl-tRNA Prolyl-tRNA Glutaminyl-tRNA aspartyl-[protein] glutamyl-[protein] -protein ECHS1 4,5-bisphosphate 4- phosphatidylinositol- fatty acyl-CoA numbered straight chain 2: SGPP2 2: SPHK2 DNA-binding nucleoside tetrakisphosphate UMP thymidylate thymidine mitochondrial: GATB synthetase: HS15715 mitochondrial: IARS2 mitochondrial: AARS2 synthetase: EPRS1 synthetase: GARS1 cytoplasmic: HARS1 cytoplasmic: DARS1 mitochondrial: LARS2 cytoplasmic: CARS1 synthetase: VARS1 synthetase: NARS1 cytoplasmic: YARS1 mitochondrial: WARS2 [+ 2 isozymes] cytoplasmic: RARS1 cytoplasmic: MARS1 synthetase: EPRS1 synthetase: QARS1 [+ 2 isozymes] an N-terminal (3S)-3-hydroxy-2- dehydrogenase: lipase: LIPE enoyl-CoA acetate inositol-1,3,4,5- pyruvate leukotriene A thymidylate diphosphate cytoplasmic: SARS1 transferase: phosphatase: PIP4P1 3,4,5-trisphosphate 5- carnitine/ 2,3,4-saturated fatty acyl CoA Sphingosine- Sphingosine Aldo-keto reductase protein 1-like 5-phosphatase: 4 5-hydroxy-L- GMP synthase: synthase: kinase: TK2 arginyl-tRNA- arginyl-tRNA- isomerase: acetate acetyl-coA myo-inositol- GDP adenylo-succinate nucleoside kinase: DTYMK 3-sulfo-L- ATE1 propylpentanoyl- phosphatase: INPP5K acylcarnitine ACADL tetrakisphosphate 5- INPP5B tryptophan adenine GMPS kinase: NME4 -protein -protein phosphatidylinositol a 2-acylglycerol 1-phosphate kinase family 1 member acetyl-coA synthetase: 4-phosphate diphosphate TYMS alanyl-[protein] CoA phosphatidylinositol- translocase: a (2E)-2-ECI2 purine- an L-glutaminyl- Lys Ile Ala Glu ser Gly His asp Leu Cys Val Asn Tyr Trp Phe Arg Met Pro Gln Thr Met 4,5-bisphosphate 4- [+ 4 isozymes] straight chain phosphatase 1: SPHK1 B10: AKR1B10 acetyl-coA monophosphatase: phosphatase: OCRL inositol-1,3,4,5- decarboxylase: kinase: NME4 dTDP dCDP kinase: an L-lysyl-[tRNA ] an L-isoleucyl-[tRNA ] an L-alanyl-[tRNA ] an L-glutamyl-[tRNA ] an L-seryl-[tRNA ] a glycyl-[tRNA ] an L-histidyl-[tRNA ] an L-aspartyl-[tRNA ] an L-leucyl-[tRNA ] an L-cysteinyl-[tRNA ] an L-valyl-[tRNA ] an L-asparaginyl-[tRNA ] an L-tyrosyl-[tRNA ] an L-tryptophanyl-[tRNA ] an L-phenylalanyl-[tRNA ] an L-arginyl-[tRNA ] an L-methionyl-[elongator tRNA ] an L-prolyl-[tRNA ] an L-glutaminyl-[tRNA ] an L-threonyl-[tRNA ] an L-methionyl-[initiator tRNA ] transferase: transferase: an N-terminal L- a (2E)-2-methyl-2-enoyl-CoA synthetase: ACSS2 Claudin-23 leukotriene A-4 leukotriene C4 adenylosuccinate [tRNA Gln ] arginyl-tRNA- 4,5-bisphosphate 5- SLC25A20 enoyl-CoA (R)-2-hydroxy [+ 4 isozymes] DDC nucleoside:phosphate NME1 NME2 ATE1 ATE1 phosphatase: PIP4P2 1: SGPP1 L-1,2-propanediol synthetase: ACSS2 IMPA2 tetrakisphosphate 5- hydrolase: LTA4H synthase: LTC4S lyase: ADSL dCDP kinase: -protein arginiyl-3-sulfino- phosphatase: INPP5E a 1-phosphatidyl- hormone-sensitive [+ 2 isozymes] D-myo-inositol 3,4-dihydroxyphenylacetaldehyde dTDP kinase: ribosyltransferase: PNP GMP an N-terminal an N-terminal an O-(long-chain- 2-methylenoyl- fatty acyl-CoA reductase: AKR1B1 ACSS2 phosphatase: OCRL [+ 5 isozymes] L-alanyl-[protein] 1D-myo-inositol lipase: LIPE sphingosine [+ 2 isozymes] myo-inositol- (1,3,4)- serotonin NME1 NME2 adenosine transferase: 3-oxo-2- a 1-phosphatidyl- hosphatidylinositol- acyl)-L-carnitine CoA hydratase: lyase: HACL1 acetyl-CoA NME1 NME2 L-arginiyl-L- L-arginiyl-L- [+ 2 isozymes] 4-phosphate [+ 4 isozymes] AMP ATE1 3,4-bisphosphate 1-phosphate Uncharacterized trisphosphate leukotriene B leukotriene-C4 [+ 5 isozymes] dCTP aspartyl-[protein] glutamyl-[protein] propylpentanoyl- 1D-myo-inositol 4,5-bisphosphate HADHA (S)-propane-1,2-diol acetyl-CoA 4 nucleoside an N-terminal L- monophosphatase: D-myo-inositol serotonin N- GDP GMP kinase: CoA phosphatidylinositol- glycerol an odd numbered acetyl-CoA protein C16orf92 AMP dCTP adenosine 5-phosphate 5-phosphatase: a (3S)-3-hydroxy- a fatty acid IMPA1 (1,3,4)- γ acetyltransferase: reductase: diphosphate GUK1 arginiyl-3-sulfo- 3,4-bisphosphate 4- straight chain 2,3,4- formyl-CoA leukotriene-C4 -glutamyl dTMP kinase: AK5 kinase: NME4 deaminase: L-alanyl-[protein] INPP5K 2-methylacyl-CoA trisphosphate AANAT RRM1 RRM2 phosphatase: INPP4B O-palmitoyl- saturated fatty aldehyde Ras-related inositol-4-phosphate (S)-norlaudanosoline transferase: GGT5 [+ 6 isozymes] ADA thymidylate phosphatidylinositol- inositol 1,3,4- [+ 5 isozymes] GDP 3-hydroxy-2- monophosphatase: Ribonucleoside- tRNA splicing II phosphatidylinositol- L-carnitine straight chain protein gamma- N-acetyl-serotonin GDP kinase: kinase: procollagen hydroxylation and glycosylation 4,5-bisphosphate 5- (2E)-hexadecenal triphosphate 6 diphosphate methylacyl-CoA fatty aldehyde BPNT2 glutamyltranspeptidase: NME1 NME2 ADP pentanoyl-CoA 3,4-bisphosphate 4- carnitine O- Rap-1b- kinase: ITPK1 inosine DTYMK phosphatase: OCRL dehydrogenase: hydroxyindole O- reductase dTTP GDP kinase: GDP reductase: a polycistronic phosphatase: INPP4A dehydrogenase: like protein D-myo-inositol 11-oxyandrogens biosynthesis GGT2 nucleoside Phosphatidylinositol- palmitoyltransferase: formate phosphatidylinositol HADHA myo-inositol methyltransferase: subunit M2 B: ADP CMP NME1 NME2 RRM1 RRM2 dTDP a [procollagen]-L-proline a [procollagen]-L-lysine tRNA precursor 3,4,5-trisphosphate a 1-phosphatidyl- CPT1C ALDH3A2 Prostaglandin Aldehyde Degradation (1,3,4,6)- diphosphate inosine 4,5-bisphosphate 5- an odd numbered leukotriene-D4 ASMT RRM2B RRM1 reductase: phosphorylation 1D-myo-inositol reductase Chondroitin tetrakisphosphate (S)-reticuline kinase: NME4 phosphorylase: nucleoside Ribonucleoside- dTDP kinase: procollagen- 3-phosphatase carnitine O- a 2-methyl-3-oxoacyl-CoA pregnenolone RRM1 RRM2 phosphatase: INPP5F 3-phosphate straight chain 2,3,4- 1: PTGR1 sulfate inositol 1,3,4,6- CMP diphosphate diphosphate NME1 NME2 prolyl 4- (2E)-pent- TPTE2: TPTE2 palmitoyltransferase: β (2E)- methylglyoxal LTD4 dipeptidase 2: DPEP2 melatonin [+ 5 isozymes] PNP prolyl 3- lysine 5- tRNA-splicing phosphatidylinositol- fatty acid -oxidation (peroxisome) saturated fatty acid methylglyoxal degradation VI methylglyoxal degradation I proteoglycan 5 tetrakisphosphate Ribonucleoside- CMP kinase: kinase: NME4 reductase propanoyl-CoA C hexadecenoate degradation III α nucleoside hydroxylase: hydroxylase: dioxygenase: endonuclease 2-enoyl-CoA phosphatidylinositol- phosphatidylinositol- CPT1A fatty acid-CoA pregnenolone 17- - LTE4 dipeptidase: DPEP1 4,5-bisphosphate 5- phospholipases -acyltransferase: 5-kinase: IPMK diphosphate CMPK1 hypoxanthine [+ 5 isozymes] subunit M2 B: diphosphate P4HB P4HA1 PPIB PLOD1 subunit Sen2: pentenoyl- 3,4-bisphosphate 3- 3-phosphate 3- carnitine ligase: SLC27A2 palmitaldehyde (2E)- D-myo-inositol hydroxylase: CYP17A1 phosphatase: INPP5J a (2E)-2-enoyl-CoA reductase RRM2B RRM1 1-phosphatidylinositol- HADHB hexadecenoate--CoA methylglyoxal methylglyoxal methylglyoxal leukotriene-E4 UMP-CMP kinase: NME4 [+ 2 isozymes] CRTAP P3H1 [+ 3 isozymes] TSEN2 TSEN54 CoA phosphatase: PTEN phosphatase: PTEN palmitoyltransferase: [+ 3 isozymes] semaf 1,3,4,5,6- [+ 4 isozymes] subunit M2 B: TSEN15 4,5-bisphosphate a 2,3,4-saturated an odd numbered ligase: ACSL1 β acetol Lactoylglutathione 17-α-hydroxypregnenolone kinase: CMPK2 hypoxanthine [+ 5 isozymes] [+ 2 isozymes] a [procollagen]-(5R) hydratase: phosphatidylinositol- CPT1B fatty acid -oxidation pentakisphosphate dGDP RRM2B RRM1 CDP phosphodiesterase: PLCD1 fatty acyl CoA monooxygenase: lyase: GLO1 phosphoribosyltransferase: GTP a [procollagen] trans TSEN34 ECHS1 3-phosphate 3- straight chain 2,3,4- (2E)- α dTTP -5-hydroxy-L-lysine carnitine O- CYP2E1 (R)-S- 17- - HPRT1 4-hyroxy-L-proline (3S)-3- 1-phosphatidylinositol- saturated fatty acyl CoA hexadecenoyl-CoA inositol-1,3,4,5,6- inositol- myo-inositol-1,3,4,5,6- inositol-1,3,4,5,6- inositol-1,3,4,5,6- nucleoside dGDP a [procollagen]-trans phosphatase: palmitoyltransferase: a (3Z)-alk-3-enoyl-CoA lactoylglutathione hydroxypregnenolone procollagen a 5'-half-tRNA a 3'-half-tRNA Aldo-keto reductase Claudin-14 myo-inositol (1,4,5,6) dADP diphosphate -3-hydroxy-L-proline hydroxypentanoyl- α MTMR14 4,5-bisphosphate CPT2 (R)-lactaldehyde pentakisphosphate tetrakisphosphate pentakisphosphate 1- pentakisphosphate pentakisphosphate galactosyltransferase: fatty acid -oxidation Hydroxyacylglutathione -tetrakisphosphate 3- 17,20-lyase: CYP17A1 IMP lipoate biosynthesis ubiquinol-10 biosynthesis thio-molybdenum γ Cofactor, Carrier, and Vitamin Biosynthesis molecule with molecule with CoA phosphodiesterase: PLCG2 branched family 1 member nucleoside kinase: NME4 nucleoside glutathione- thiamine salvage III retinol biosynthesis flavin -glutamyl cycle NAD tetrahydrofolate salvage from folate transformations I 2-kinase: IPPK 1-kinase: ITPK1 phosphatase: ITPK1 3-phosphatase: kinase: IPMK NAD de novo biosynthesis [2Fe-2S] iron-sulfur cluster biosynthesis COLGALT1 phosphatidylinositol- enoyl-CoA cis3,trans2-enoyl- hydrolase, phosphatase: IPMK aspirin triggered resolvin E biosynthesis and incorporation cofactor biosynthesis a 2',3'-cyclic a 5'-OH end a 1-phosphatidyl- palmitoyl-CoA chain fatty B10: AKR1B10 MINPP1 β diphosphate nucleoside diphosphate glutaredoxin biosynthesis phosphorylation and 5,10-methenyltetrahydrofolate 3S-hydroxyacyl- a 3-methyl-branched 3-phosphate 3- 1-phosphatidylinositol- hydratase: inositol 3- -hydroxyandrost-5-en-17-one GTP CDP kinase: the visual cycle I (vertebrates) procollagen acyl-CoA CoA isomerase: ECI1 mitochondrial: HAGH D-myo-inositol kinase: NME4 diphosphate kinase: NME4 redox reactions MoO - transhydrogenation Formyltetrahydrofolate phosphate end CoA 1D-myo-inositol 4,5-bisphosphate fatty acid- enoyl-CoA palmitoyl-CoA methylglyoxal a [glycerolipid]-(5Z,8Z,11Z,14Z,17Z) NME1 NME2 thiamine β-carotene (2E,6E)-farnesyl diphosphate 3 glutathione a 5,10- 2,3,4-saturated fatty acid phosphatase: MTMR3 ECHS1 Aip-5 Ins(1,2,3,4,5,6)P pentakisphosphate riboflavin a tetrahydrofolate synthetase: MTHFD1 galactosyltransferase: 4-phosphate oxidase: hydratase: 6 (3,4,5,6)- D-myo-inositol dGDP kinase: kinase: NME4 an octanoyl-[acp] trp L-cysteine desulfurase molybdopterin + protein S-nitrosylation and denitrosylation dehydrogenase: phosphodiesterase: PLCE1 CoA ligase: reductase: AKR1B1 (R)-lactate kinase: IP6K3 -icosapentaenoate [+ 5 isozymes] dGDP kinase: glutathione Thiamin an all-trans-retinol-(plasma- decaprenyl cys NAD methenyltetrahydrofolate COLGALT2 3-methyl-branched phosphatidylinositol ACOX2 enoyl-CoA a (2E)-2-enoyl-CoA tetrakisphosphate DHA dehydrogenase: β,β-carotene 15,15'- cofactor riboflavin methenyltetrahydrofolate formyltetrahydrofolate tRNA- EHHADH a 2,3,4-saturated SLC27A2 HSD17B4 hydroxyacetone (R)-propane- (1,4,5,6)- NME1 NME2 dADP kinase: NME1 NME2 pyrophosphokinase lipoyl(octanoyl) tryptophan 2,3- diphosphate synthase: NAD kinase: fatty acid-CoA phosphatidylinositol 3-phosphate 3- 1-phosphatidylinositol- hydratase: (R)-lactate inositol-1,3,4,5,6- CTP retinol-binding-protein) cysteine γ a [procollagen]-(5R)-5-O-(β- splicing fatty acid Probable D-lactate inositol inositol inositol tetrakisphosphate HSD3B1 [+ 5 isozymes] NME1 NME2 [+ 5 isozymes] 1: TPK1 transferase: dioxygenase: monooxygenase: kinase: RFK glutathione - cyclohydrolase: MTHFD1 synthetase: MTHFD1 a [protein]- (3S)-3- 4-phosphate 4- 4,5-bisphosphate [+ 3 isozymes] acyl- 1,2-diol Protocadherin pentakisphosphate PDSS1 PDSS2 NADK an N 10 - ligase: SLC27A2 phosphatase: SACM1L EHHADH Aldo-keto reductase DHA dehydrogenase: thiamine TDO2 desulfurase: BCO1 Molybdenum FMN glutamyltransferase: formyltetrahydrofolate L-cysteine D-galactosyloxy)-L-lysine ligase: phosphatase: SACM1L coenzyme 3-hydroxyacyl-CoA D-lactate dehydrogenase, hexakisphosphate hexakisphosphate hexakisphosphate [+ 5 isozymes] a reduced a [lipoyl-carrier LIPT2protein] all-trans-decaprenyl diphosphate glutathione + hydroxyacyl-CoA [+ 3 isozymes] phosphodiesterase: PLCB2 family 1 member alpha-9 kinase: IP6K1 androstenediol diphosphate plasma retinol- NFS1 GGT5 NADP formyltetrahydrofolate ZBTB8OS mitochondrial: kinase 3: IP6K3 5-kinase: IP6K1 kinase 3: IP6K3 HSD3B2 dGTP 6 tryptophan 2,3- cofactor synthase: MTHFD1L dehydrogenase: A oxidase: dehydrogenase: a 2,3,4-saturated fatty acid enoyl-CoA dehydrogenase (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate glutaredoxin N -octanoyl-L-lysine synthetase: a 1-phosphatidyl- 1-phosphatidylinositol- B10: AKR1B10 Inositol binding protein: RBP4 all-trans-retinal FAD γ RTCB a 3-methyl-branched 2,3,4- a 2,3,4-saturated a 2,3,4-saturated (3S LDHD Steroid Delta- dGTP dATP dioxygenase: an S-sulfanyl-[L- 4-hydroxybenzoate sulfurase: GSS -glutamyl NAD(P) phosphoribosylglycinamide HADH 1D-myo-inositol ACOX1 HSD17B10 hydratase: ECHS1 a 2,3,4-saturated (3R)-3-hydroxyacyl-CoA (cytochrome) Inositol Inositol Inositol glutathione an N 10 - saturated fatty acyl-CoA 4,5-bisphosphate fatty acyl CoA )-3-hydroxyacyl-CoA L-1,2-propanediol BTB/POZ hexakisphosphate lipoyl MOCOS synthetase: transpeptidase formyltransferase: GART C2orf49 glycerol : LDHD hexakisphosphate hexakisphosphate hexakisphosphate 5-androstene-3,17-dione isomerase: HSD3B2 18R-hydro(peroxy)- IDO2 cysteine desulfurase] decaprenyltransferase: transhydrogenase: a [protein] 3- a [procollagen]-(5R)-5-O- (3S)-3- phosphodiesterase: PLCB1 (3S)-3- fatty acid-CoA enoyl-CoA pyruvate domain- and diphosphoinositol- reductase: all-trans-retinol synthase: LIAS FLAD1 formyltetrahydrofolate α β RTRAF 3-methyl-branched degradation reductase: AKR1B1 kinase 1: IP6K1 and diphosphoinositol- kinase 1: IP6K1 steroid Delta- EPE synthase: PTGS2 indoleamine 2,3- all-trans-retinol UBIAD1 NNT nitrosothio- [ -D-glucosyl-(1->2)- -D- hydroxyacyl-CoA hydroxyacyl-CoA hydratase: HADHA containing pentakisphosphate TXNDC12 a [lipoyl-carrier Mo(O) (S)- a tetrahydrofolate FAM98B 2,3,4-saturated a 1-phosphatidyl-1D-myo- [+ 9 isozymes] a 2,3,4-saturated (3R ligase: SLC27A2 pyruvate androstenedione dehydrogenase 2 galactosyl]-5-hydroxy-L-lysine a 1,2-diacyl-sn-glycerol (S)-propane-1,2-diol pentakisphosphate isomerase: HSD3B1 a protein with 6 dioxygenase: 4-hydroxybenzoate FAD L-alanine dehydrogenase: dehydrogenase: protein inositol inositol kinase 1: PPIP5K1 protein]-N -[(R)- molybdopterin ala NADPH DDX1 fatty acyl-CoA 2- inositol 4,5-bisphosphate glycerol )-3-hydroxyacyl-CoA [+ 3 isozymes] isomerase: HSD3B1 (18R)-hydroxyicosapentaenoate all-trans-retinol (NADP): RDH8 protein- a 2,3,4-saturated fatty acyl CoA 3-hydroxyacyl-CoA hexakisphosphate kinase 1: PPIP5K1 hexakisphosphate reduced L- IDO1 decaprenyltransferase: cofactor HADH HADH a 2,3,4-saturated (3S)-3-hydroxyacyl-CoA KCTD19 17β-hydroxyandrost-5-en-3-one dihydrolipoyl]-L-lysine N-Formyl-L- an S-sulfanyl-[cysteine hydroxylase: PHYH acetone degradation I (to methylglyoxal) glycerol Inositol androstenedione dehydrogenase glucosylgalactosylhydroxylysine dehydrogenase: HSD17B10 3-kinase: PPIP5K1 1-kinase: PPIP5K1 cysteine residues all-trans-retinol COQ2 10-formyltetrahydrofolate 3-hydroxyacyl-CoA 3R-hydroxyacyl- (3S)-3- Inositol (18R)- kynurenine desulfurase]-[disordered- molybdenum cofactor biosynthesis methionine a 2-hydroxy-3-methyl-branched kinase: GK hexakisphosphate isomerase: HSD3B2 (NADP): RDH8 dehydrogenase: glucosidase: PGGHG phosphatidylcholine CoA 3-hydroxyacyl-CoA Transforming hydrolase: ALDH1L2 dehydrogenase: hydroxyacyl-CoA inositol hexakisphosphate inositol hydroxyicosapentaenoate kynurenine form scaffold 3-decaprenyl-4-hydroxybenzoate synthase: methenyltetrahydrofolate a spliced tRNA 2,3,4-saturated fatty acyl-CoA [+ 3 isozymes] coenzyme A and diphosphoinositol- all-trans-retinol Retinol-binding RDH10 β propan-2-ol cholineesterase: PLD1 dehydrogenase: dehydrogenase: HADHA growth factor and diphosphoinositol- 10-formyltetrahydrofolate a [protein]- a [procollagen]-(5R)-5-O-( - HSD17B10 sn-glycerol dehydrogenase: hexakisphosphate hexakisphosphate pentakisphosphate androst-4-ene-3,17-dione 5-lipoxygenase: ALOX5 protein 5: RBP5 formamidase: protein] complex an α-(γ-L- ATP MTR cyclohydrolase: MTHFD1 S-nitrosoglutathione beta activator dehydrogenase: RDH10 all-trans-retinol γ-L-glutamyl- L-cysteine D-galactosyloxy)-L-lysine [+ 4 isozymes] 3-phosphate HSD17B4 HADH (3S)-3-hydroxyacyl-CoA 3-kinase: PPIP5K2 pentakisphosphate 1-kinase: PPIP5K2 (5S,18R)-18-hydroxy-5- AFMID a dietary all- 3-decaprenyl-4- cys gly glutamyl)-L- hydrolase: ALDH1L1 methenyltetrahydrofolate 3-oxopentanoyl- 2-hydroxy-3-methyl- a phosphatidylcholine a phosphatidate LRRC33 kinase 2: PPIP5K2 all-trans-retinol cellular retinol- dehydrogenase: L-cysteine cys a (6S)-5- acetoacetate dehydrogenase: HADH Inositol kinase 2: PPIP5K2 Inositol hydroperoxyicosapentaenoate trans-retinyl ester hydroxybenzoate amino acid molybdopterin- GTP cyclohydrolase: MTHFD2 S-nitrosoglutathione CoA branched 2,3,4- propan-2- 3S-hydroxyacyl- inositol androstenedione 11β- androstenedione 17β- dehydrogenase: RDH12 binding protein: RBP2 formyltetrahydrofolate lipoxin biosynthesis L-kynurenine RDH12 hydroxylase: COQ6 synthase acetyl-CoA ol:NADP+ CoA 3-ketoacyl-CoA (3S)-3-hydroxyacyl-CoA ADP- hexakisphosphate inositol hexakisphosphate a [cysteine desulfurase]- cysteine reductase: ADH5 saturated fatty acyl- pentakisphosphate hydroxylase: CYP11B1 reductase: HSD17B3 NADP-retinol cellular retinol- NADP-retinol Hepatic cys-gly oxidoreductase: acetoacetate dehydrogenase: HADH ribosylation kinase 2: IP6K2 hexakisphosphate kinase 2: IP6K2 (18R)- 3,4-dihydroxy-5-all- γ-glutamylcyclotransferase: desulfurase: adenylyltransferase: GTP 3',8'- serine acetyltransferase: CoA lyase: HACL1 phosphatidylcholine sn-2 dehydrogenase: thiolase: SCP2 kinase: IP6K2 androstenedione dehydrogenase: DHRS3 binding protein: RBP1 S-sulfanyl-[disordered- 5-formyltetrahydrofolate S-(hydroxysulfenamide) 5-oxo-L-proline metabolism kynurenine 3- dehydrogenase: triacylglycerol dipeptidase: hydroxymethyltransferase: methenyltetrahydrofolate ADH1B decarboxylase EHHADH factor 3 kinase: IP6K2 arachidonate hydroxyicosapentaenoate trans-decaprenylbenzoate GGCT NFS1 MOCS3 cyclase: ACAT2 acylhydrolase: PLA2G1B DHAP a 2,3,4-saturated a 2,3,4-saturated a 2,3,4-saturated fatty acyl CoA3-ketoacyl-CoA a 2,3,4-saturated 3-oxoacyl-CoA reductase: AKR1C3 monooxygenase: form scaffold cyclo-ligase: MTHFS glutathione bilirubin 1D-myo-inositol 1D-myo-inositol 11OHA4 5-lipoxygenase: ALOX5 all-trans-retinol DHRS3 lipase: LIPC CNDP2 an [L-cysteine a carboxy-adenylated SHMT1 dehydrogenase: MTHFD2L a 2-methyl branched 2,3,4- phospholipase A : PLAAT3 thiolase: ACAA2 inositol a diphospho- protein] complex decaprenyldihydroxybenzoate glutamate- MOCS1 a [protein] with acetyl-CoA 2 fatty acyl CoA 3-oxoacyl-CoA 3-diphosphate 1-diphosphate resolvin E2 dehydrogenase an all-trans retinol-[cellular- KMO formyl-CoA glucuronosyltransferase 1D-myo-inositol all-trans-retinol all-trans- desulfurase]-S- [small subunit of (8S)-3',8-cyclo-7,8- serine methylenetetrahydrofolate acetyltransferase saturated fatty aldehyde phosphatidylcholine 2- acetyl-CoA C- Phospholipid hexakisphosphate arachidonate 5- all-trans-retinal methyltransferase: COQ3 -cysteine a 5,10- an N-terminal acetone (C isomer- 1,2,4,5,6- 2,3,4,5,6- arachidonate (7E,9E,11Z,14Z,18R,16E)- (NADP): RDH11 retinol-binding-protein] 12 testosterone 3-hydroxy- dehydrogenase retinyl ester sulfanyl-L-cysteine molybdopterin synthase] dihydroguanosine hydroxymethyltransferase: dehydrogenase: MTHFD1 a [protein] with monomer: ACAT1 acylhydrolase: PLA2G4A acyltransferase: HADHB scramblase 2 kinase: IP6K3 tetrakisphosphate 11β- 11β- lipoxygenase: ligase: L-cysteinylglycine methenyltetrahydrofolate L-glutamine 2-methyl branched forming): UGT1A4 pentakisphosphate pentakisphosphate 15- (5S,6S)-5,6-epoxyicosa-15- [+ 2 isozymes] 3-methoxy-4-hydroxy-5-all- L-kynurenine (NADP): RDH11 hydrolase: 5'-triphosphate SHMT2 methenyltetrahydrofolate menaquinol-4 biosynthesis II an N-terminal fatty aldehyde cytochrome P450 [+ 21 isozymes] hydroxyandrostenedione hydroxyandrostenedione 11- β GCLC acetyl-CoA C- testosterone 11 - ALOX5 lipoxygenase: hydroxy-7,9,11,14,18-pentaenoate an S-sulfanyl-[cysteine trans-decaprenylbenzoate hydroxylamine 1D-myoinositol [+ 2 isozymes] PNLIP molybdopterin cyclic cyclohydrolase: MTHFD2 L-glutamate 2A6: CYP2A6 a phosphatidylcholine a 2-lysophosphatidylcholine 5α-reductase: SRD5A2 dehydrogenase: HSD11B1 GCLM glutaminyl-peptide acyltransferase: dehydrogenase: C12-β-glucuronosyl- Olfactory 3-diphosphoinositol 1-diphosphoinositol hydroxylase: CYP11B2 ALOX15B resolvin E1 kynureninase: desulfurase]-S- synthase pyaropterin 5-diphosphate β β a 5,10- cyclotransferase: HADHB formate ALDH3A2 acetone α receptor pentakisphosphate pentakisphosphate 11 - 11 - testosterone 11β- KYNU sulfanyl-[disordered- cobalamin salvage (eukaryotic) phylloquinone bilirubin-IX synthase: LTA4H sulfurtransferase: phosphate a 5-methyltetrahydrofolate 1,2,3,4,6- (5S)-HPETE methylenetetrahydrofolate glutathione QPCT a 2-methyl branched monooxygenase: 4K1 5-kinase: IP6K1 5-kinase: IP6K1 hydroxyandrostenedione hydroxyandrostenedione 11- hydroxylase: CYP11B1 form scaffold all-trans-retinol MOCS3 3-ketoacyl- phospholipase A : PLAAT3 acetyl-CoA pentakisphosphate synthase: CYP2E1 1 3-ketoacyl- α (15S)-HPETE 3-hydroxyanthranilate 6-(all-trans-decaprenyl) 2,3,4-saturated fatty acid 3-diphosphoinositol 1-diphosphoinositol 5 -reductase: SRD5A1 dehydrogenase: HSD11B2 arachidonate 5- resolvin E1 protein] complex MOCS1 a [protein] with CoA phospholipase A : PLAAT4 bilirubin glucuronoside 11OHT Retinol- -2-methoxy-phenol cyanocob(III)alamin methylenetetrahydrofolate ammonium glutathione-specific γ- [+ 3 isozymes] 1 CoA thiolase: Protocadherin pentakisphosphate pentakisphosphate lipoxygenase: 15S-HETE a thiocarboxylated menadione an N-terminal 5- thiolase: 2-methyl branched phospholipase A : PLAAT2 glucuronosyltransferase: binding reductase (NADPH): MTHFR 1 SCP2 plasmalogen degradation 3-hydroxyanthranilate [small subunit of cyclic pyranopterin glutamylcyclotransferase: ACAA2 medium-chain UGT1A4 gamma-B3 5-kinase: IP6K3 5-kinase: IP6K3 11β-hydroxy-5α-androstanedione 11KA4 β ALOX5 synthase: lecithin:all-trans retinol coenzyme Q10 cyanocobalamin glu 5-oxo-L-proline oxo-L-proline hydroxyacetone phospholipase A : PLAAT1 11 -hydroxytestosterone 2-arachidonoylglycerol biosynthesis 3,4-dioxygenase: HAAO protein phosphate γ-L-glutamyl 1 3-ketoacyl- acyltransferase: LRAT monooxygenase: COQ6 molybdopterin synthase] NAD salvage CHAC2 acyl-coenzyme A α ALOX15 reductase 3-ketoacyl- phospholipase A : PLAAT5 3-diphosphoinositol 1-diphosphoinositol 5 -reductase: SRD5A1 a [cysteine 5: RBP5 1 1D-myo-inositol hexakisphosphate leukotriene A 2-amino-3- γ 5-phosphate CoA thiolase: a plasmenylethanolamine a plasmenylcholine Secretory 4 (cyanide- glutathione-specific - pyroglutamyl- CoA synthetase: ACSM1 pentakisphosphate pentakisphosphate β α 11β-hydroxytestosterone (15S)- a 1-acyl-2-arachidonoyl- desulfurase]-(S- all trans-decaprenyl-2- [+ 2 isozymes] ACAA1 biosynthesis V (from Ins(1,3,4)P3) 11 -hydroxy-5 - carboxymuconate- cellular retinol- molybdopterin glutamylcyclotransferase: peptidase a phosphatidylcholine a 1-lysophosphatidylcholine carrier- 5-kinase: IP6K2 5-kinase: IP6K2 hydroxyarachidonate sulfanyl) -[disordered- methoxy-6-1,4-benzoquinol eliminating) nicotinamide protein NEDDylation thiolase: 2-methyl branched androstanedione 5α-reductase: SRD5A2 sn-glycerol 3-phosphate 2 coenzyme A biosynthesis plasmenylethanolamine phosphatidylcholine D-myo-inositol 6-semialdehyde binding synthase: menadiol associated β a 1-acyl-2-arachidonoyl- : MMACHC CHAC1 I: PGPEP1 fatty acid-CoA 11 -hydroxytestosterone form scaffold nicotinamide ACAA1 2-acylhydrolase Inositol Inositol (1,3,4)- 11-dehydrogenase: 11-oxoandrostenedione a 1-acyl-2-arachidonoyl-sn- protein: RBP2 ubiquinone biosynthesis MOCS2 1,1-dihydroxypropan-2-one 2-acylhydrolase b membrane 11-dehydrogenase:11β-hydroxydihydrotestosterone phosphatidylcholine a metarhodopsin II an all-trans-retinyl ester protein] complex cob(II)alamin- phosphoribosyltransferase: a [NEDD8] C- 3-ketoacyl- anandamide ligase: SLC27A2 hexakisphosphate hexakisphosphate trisphosphate HSD11B2 5α-reductase: SRD5A2 (5S,7E,9E,11Z,13E,15S) glycero-3-phospho-D-myo- methyltransferase: COQ5 retinoate menadiol a 1-O-(alk-1-enyl) a 1-(1-alkenyl) protein 5 11-oxoandrostenedione HSD11B1 phosphatidate cellular retinol- [cyanocobalamin NAD biosynthesis from 2-amino- (R)-pantothenate NAMPT terminal glycine degradation [+ 3 isozymes] phosphatidylcholine CoA inositol 4,5-bisphosphate biosynthesis I geranylgeranyltransferase: E1 NEDD8- 5-oxo-L-proline and diphosphoinositol- and diphosphoinositol- β -15-hydroperoxy- (5S,6E,8Z,11Z,13E,15S) binding pantothenate kinase: PANK2 phosphohydrolase -sn-glycero-3- -sn-glycero-3- 5-diphosphoinositol- 11-oxoandrostenedione 17 -reductase: HSD17B3 phosphatase: PLPP4 6-methoxy-3-methyl-2-all-trans reductase CblC] molybdopterin 3-carboxymuconate semialdehyde NMN vitamin K-epoxide cycle inositol 1,3,4- inositol 1,3,4- 11β-hydroxytestosterone UBIAD1 activating thiolase: a 2-methyl branched 2,3,4- a phosphatidylcholine a 1,2-diacyl-sn-glycerol pentakisphosphate pentakisphosphate pentakisphosphate 5α-reductase: SRD5A1 5-hydroxyicosa- -5-hydroperoxy- phosphatidylcholine quinolinate protein: RBP1 CblC-CblD an all-trans-retinol- pantothenate kinase: PANK1 anandamide phosphoethanolamine phosphocholine 11-ketoandrosterone [+ 6 isozymes] -decaprenyl-1,4-benzoquinol 5-oxoprolinase: SCP2 kinase 1: PPIP5K1 kinase 1: PPIP5K1 triphosphate 6 triphosphate 5 11-dehydrogenase: 7,9,11,13-tetraenoate phosphohydrolase (plasma-retinol- 2-amino-3- enzyme: 5-oxoprolinase: saturated fatty acyl-CoA P40 3-kinase: PPIP5K1 5-diphosphoinositol- 15-hydroxyicosa- 2-arachidonoyl-1- a [cysteine desulfurase]- an all-trans retinol- binding: OPLAH molybdopterin pantothenate kinase: PANK3 nicotinamide menaquinol-4 anandamide kinase: ITPK1 kinase: ITPK1 reductase: AKR1C3 HSD11B2 nicotinate-nucleotide 5-demethoxyubiquinol carboxymuconate- phylloquinol NAE1 UBA3 OPLAH methylglyoxal 1-O-(alk-1-enyl) alkenylglycerophosphoethanolamine alkenylglycerophosphoethanolamine 1-(1-alkenyl)- alkenylglycerophosphocholine Inositol Inositol 6,8,11,13-tetraenoate hosphatidylinositol- [scaffold protein- [cellular-retinol- MMADHC binding-protein)plasma adenylyltransferase: (R)-4'-phosphopantothenate mononucleotide quinone peptidyl- an [E1 NEDD8- propanoyl-CoA amidohydrolase: alkenylglycerophosphocholine 5-diphosphoinositol- pentakisphosphate lipoxin B4 (15S)- pyrophosphorylase: hydroxylase: COQ7 6-semialdehyde -sn-glycero-3- hydrolase: TMEM86B phosphodiesterase: ENPP2 sn-glycero-3- hydrolase: TMEM86B hexakisphosphate hexakisphosphate 11β-hydroxydihydrotestosterone 2-arachinodinoyl- 4,5-bisphosphate (2Fe-2S)] complex binding-protein] cob(II)alamin- retinol-binding GPHN adenylyltransferase: reductase glutamate 4- activating enzyme]- FAAH phosphodiesterase: ENPP2 pentakisphosphate 1-kinase: PPIP5K1 D-myo-inositol D-myo-inositol synthase: hydroxyarachidonate QPRT glu phosphoethanolamine phosphocholine and diphosphoinositol- and diphosphoinositol- 11-dehydrogenase: HSD11B2 phosphatidylinositol phosphodiesterase: lecithin:all- [CblC-CblD protein: RBP4 molybdopterin phosphopantothenate- NMNAT3 (thioredoxin) carboxylase: S-[NEDD8 protein]- anandamide a 1-O-(alk-1- hSEZ-6 3-kinase: PPIP5K2 5-diphosphoinositol- (1,3,4,6)- (1,3,4,5)- 11-oxo-5α-androstanedione ALOX12 5-lipoxygenase: ALOX5 3-demethylubiquinol-10 phosphohydrolase sn-glycero-3- phosphohydrolase sn-glycero-3- pentakisphosphate pentakisphosphate hydrolase: DDHD1 PLCB1 trans retinol complex] all-trans-retinol quinolinate -cysteine ligase: PPCS : VKORC1L1phylloquinone GGCX yl-L-cysteine a 1-O-(alk-1- (7E,9E,11Z,13E,15S) NaMN adenine dinucleotide nicotinamide amidohydrolase: enyl)-sn-3- pentakisphosphate tetrakisphosphate tetrakisphosphate lipoxin A4 all-trans-retinyl-ester E2 NEDD8- queuosine phosphoethanolamine phosphocholine choline kinase 2: PPIP5K2 kinase 2: PPIP5K2 acyltransferase: 3-demethylubiquinone- reductase: enyl)-sn-3- -(5S,6S)-5,6- retinoate molybdopterin mononucleotide FAAH2 phosphoglycerol 1-kinase: PPIP5K2 hydrolase: RPE65 a [co-chaperone]- cob(II)alamin Retinol- nicotinate-nucleotide (R)-4'-phosphopantothenoyl-L-cysteine conjugating biosynthesis II a 1-alk-1-enyl- a 1-alk-1-enyl- 11-oxo-5α- 11KT lipoxin B4 nicotinamide LRAT 10 3-O- cob(II)alamin NQO1 vitamin K phosphoglycerol inositol 1,3,4,6- Inositol epoxyicosa-15-hydroxy- biosynthesis II molybdotransferase: adenylyltransferase: arachidonate an 1-acyl-2-arachidonoyl-sn-glycerol [scaffold protein- transferase: binding pyrophosphorylase: phylloquinone enzyme: (queuine salvage) sn-glycerol sn-glycerol androstanedione 17β- mononucleotide methyltransferase: COQ3 transferase: 2,3-epoxide VAMP-7 tetrakisphosphate polyphosphate 7,9,11,13-tetraenoate (2Fe-2S)] complex an all-trans-retinol- protein GPHN QPRT phosphopantothenoylcysteine NMNAT2 UBE2M adenylyltransferase: an all-trans-retinyl ester MMADHC MMADHC tRNA-uridine 2-thiolation (mammalian mitochondria) queuine 5-kinase: IPMK multikinase: IPMK reductase: HSD17B3 an [E2 NEDD8- 11-ketotestosterone ubiquinol-10 (plasma-retinol- 5: RBP5 MoO -molybdopterin decarboxylase: PPCDC nicotinamide 34 lipoxin B4 lipoxin A4 2-arachidonoyl-lysophosphatidylinositol NMNAT1 cob(I)alamin 2 conjugating enzyme]- tRNA-guanosine 11-oxo-5α- α 2-arachidonoyl- a rhodopsin 11-cis-retinol cofactor NaMN mononucleotide 5 -reductase: SRD5A1 all-trans- cob(II)alamin- binding-protein)plasma cellular retinol- queuine androstanedione synthase: synthase: diacylglycerol sn-1 nicotinamide adenosyltransferase: S-[NEDD8-protein]- 4'-phosphopantetheine adenylyltransferase: cys Collectrin 11-oxotestosterone a [chaperone-ATP]- retinyl-ester [methionine retinol-binding binding vitamin-K- transglycosylase: Amine and Polyamine Degradation reductase: AKR1C3 ALOX5 ALOX5 acylhydrolase: DAGLA mononucleotide MMAB nicotinamide yl-L-cysteine spermine and spermidine degradation I GABA shunt N-acetylglucosamine 5α-reductase: SRD5A2 2-arachidonoyl-1- 2-arachidonoyl-sn-glycerol 3-phosphate [co-chaperone]- hydrolase: synthase] protein: RBP4 protein: RBP1 NMNAT1 epoxide putrescine degradation III glycine betaine mononucleotide E3 NEDD8 QTRT234 QTRT1 2-arachidonoyl- retinal-binding adenylyltransferase: all-trans-retinol 4'-phosphopantotheine cysteine a queuosine degradation II lysophosphatidylinositol- [scaffold protein- CES1 methionine an all-trans retinol- reductase: degradation II (mammalian) 3,5-bisdiphosphoinositol- D-myo-inositol cob(II)alamin- adenylyltransferase: NAD + transferase: Olfactory 4,5-bisphosphate diacylglycerol sn-1 protein: RLBP1 NMNAT2 synthase adenylyltransferase: COASY VKORC1L1 desulfurase: in tRNA spermine 1D-myo-inositol 2,3,4,6- 1,3,4,5,6- lipoxin B4 lipoxin A4 (2Fe-2S)] complex [+ 3 isozymes] tetrahydrobiopterin [corrinoid [cellular-retinol- NMNAT1 DCUN1D1 sulfide oxidation IV (metazoa) Inorganic Nutrient Metabolism 2-oxoglutarate N-acetyl-D- Retinol- NFS1 urea cycle sulfate activation thiosulfate putrescine receptor phosphodiesterase: PLCB1 acylhydrolase: DAGLB nicotinamide de novo biosynthesis adenosyltranferase] reductase: binding-protein] glutathione-peroxide redox reactions L-cysteine degradation III glutamate glucosamine glycine betaine tetrakisphosphate pentakisphosphate all-trans-retinol binding nicotinamide 3'-dephospho-CoA vitamin-K- CUL1 RBX1 an [L-cysteine Diamine N-acetyl-D- 4A15 mononucleotide MTRR all-trans-retinol for sulfonation disproportionation 1 dehydrogenase: betaine--homocysteine S- inositol-1,3,4,5,6- epoxide 6 spermine N - glucosamine protein mononucleotide a [cullin]-N -[NEDD8- desulfurase]-S- hydrogen sulfide IV (rhodanese) acetyltransferase adenylyltransferase: methylcob(III) dehydrogenase: GSSG reductase: acetyltransferase: GLUD2 methyltransferase: BHMT 1D-myo-inositol 1,5- pentakisphosphate 2-arachidonoylglycerol plasma 5: RBP5 adenylyltransferase: dephospho-CoA protein]-yl-L-lysine sulfanyl-L-cysteine arg cys 1: SAT1 kinase: NAGK NMNAT3 GTP alamin-[methionine RDH16 ammonium sulfate N-acetyl-D- 2-kinase: IPPK 11-oxodihydrotestosterone a [chaperone- retinol-binding kinase: COASY VKORC1 a uridine in tRNA pentose phosphate pathway Pentose Phosphate Pathways sulfide-glutathione thiosulfate SAT1 glutamate N,N-dimethylglycine SPR-2E bis(diphosphate) an [2Fe-2S] cob(I)alamin- synthase] cellular retinol- NMNAT2 cysteine sulfate Diamine glucosamine nicotinate adenine ADP]-[disordered- protein: RBP4 GTP cyclohydrolase: all-trans-retinol Diamine dehydrogenase: 2,3,4,6- cluster protein [corrinoid binding desulfurase:TUM1 (non-oxidative branch) quinone ammonia-dependent adenylyltransferase: cysteine acetyltransferase 6-phosphate Ins(1,2,3,4,5,6)P dinucleotide form scaffold GCH1 dehydrogenase: nicotinamide coenzyme A folate polyglutamylation 5-taurinomethyluridine- Membrane spermine GLUD1 tetrakisphosphate 6 an all-trans-retinol- 7,8-dihydroneopterin adenosyltranferase] glutathione pyridoxal 5'-phosphate salvage sulfurtransferase: oxidoreducatse: argininosuccinate carbamoyl- aminotransferase: acetyltransferase dimethylglycine protein: RBP1 mononucleotide [tRNA] synthase: D-ribulose PAPSS2 thiosulfate 2: SAT2 Putative N- Immunoglobulin glutamine- protein] complex SDR16C5 primary amine oxidase: SMOX (plasma-retinol- 3'-triphosphate cob(I)alamin an all-trans retinol- peroxidase: MPST SQOR lyase: ASL phosphate GOT1 sulfurtransferase: 1: SAT1 glu N-acetylputrescine dehydrogenase: DMGDH an all-trans retinal- adenylyltransferase: GTPBP3 MTO1 5-phosphate arginase: ARG1 sulfate acetylglucosamine- dopamine degradation heavy dependent binding-protein) adenosyltransferase: GPX2 a tetrahydrofolate a [3-mercaptopyruvate oxidase: AOC3 an 11-cis-retinal-[interphotoreceptor [cellular-retinol- NMNAT3 synthase: CPS1 2-oxo-3- TST Diamine 6-phosphate 6-pyruvoyl [cellular-retinol- pyridoxine pyridoxamine a 5-taurinomethyluridine GSSH adenylyltransferase: variable 3-43 Amine and Polyamine Biosynthesis an 11-cis-retinol-[retinal-binding protein] NAD(+) MMAB sulfurtransferase]-S Peroxisomal N(1) N-acetylputrescine retinoid-binding protein] binding-protein] glutathione ribulose- ribose-5- glutamine-dependent sulfanylpropanoate acetyltransferase glutamate deacetylase: sarcosine synthetase: thioredoxin tetrahydrobiopterin binding-protein] nicotinate adenine in tRNA -sulfanyl-L-cysteine PAPSS1 deaminase: MAOA adenosylcob(III) all-trans-retinol peroxidase: serine Formyltetrahydrofolate folylpolyglutamate pyridoxal pyridoxal phosphate carbamoyl- 2: SAT2 -acetyl-spermine/ decarboxylase: dopamine polymerase a [disordered- an [Fe-S cluster synthase: PTS all-trans-retinal dinucleotide phosphate 3- persulfide L-arginino-succinate L-ornithine APS thiocyanate sulfite AMDHD2 11-cis-retinol NADSYN1 pathway alamin-[corrinoid glutathione glutathione synthase: FPGS kinase: kinase: spermidine GLUL N-acetylputrescine I and spermine biosynthesis form [Fe-S] cluster biosynthesis dehydrogenase: dehydrogenase: GPX1 hydroxymethyltransferase: synthetase: MTHFD1 tRNA 2- epimerase: isomerase: dioxygenase: phosphate 3-mercaptopyruvate D-glucosamine sarcosine creatine biosynthesis putrescine creatine-phosphate biosynthesis histamine putrescine dehydrogenase: RDH10 (6R)-6-pyruvoyl- adenosyltranferase] peroxidase: reductase: glutamine- oxidase: PAOX oxidase: MAOB transcript + XDH SHMT1 formyltetrahydrofolate PDXK PDXK RPE RPIA ETHE1 synthase: CAD adenylyl-sulfate sulfurtransferase: glutamate NAD an oxidized scaffold protein] chaperone]-ATP ALDH1A2 glutathione dependent thiouridylase: N 1 -acetylspermine spermidine 6-phosphate dopamine dopamine catechol O- dehydrogenase: SARDH biosynthesis I biosynthesis biosynthesis III interphotoreceptor 11-cis retinol 5,6,7,8-tetrahydropterin cob(I)alamin GPX4 GSR kinase: PAPSS2 hydrogen sulfide biosynthesis II (mammalian) release factor peroxidase: serine synthetase: MTHFD1 pyridoxine pyridoxamine TRMU pentose phosphate MPST decarboxylase: deaminase: sulfotransferase: methyltransferase: Signal transduction pathways SAM retinoid-binding dehydrogenase: RDH5 thioredoxin 5,6,7,8- adenosyltransferase: all-trans-retinoate all-trans-retinal NAD(+) a tetrahydrofolate S-sulfinatoglutathione 4-acetamidobutanal gly lipoate salvage GPX3 hydroxymethyltransferase: D-xylulose D-ribose 5- ornithine carbamoyl phosphate adenylyl-sulfate spermidine N 1 - GAD2 SULT1A3 creatine protein: RBP3 tetrahydropterin:NADP+ MMAB dehydrogenase: synthetase: formyltetrahydrofolate 5'-phosphate 5'-phosphate pathway (oxidative branch) MAOB COMT gly gln y+LAT- gln arg his L-ornithine SHMT2 pyridoxal 5-phosphate phosphate carbamoyltransferase: kinase: PAPSS1 acetyltransferase: 4-acetamidobutanal glycine creatine kinase: CKMT2 adenosylcobalamin- ALDH1A1 glutathione NADSYN1 synthase: MTHFD1L a 5-taurinomethyl-2- argininosuccinate cys L-homocysteine glutamate dopamine Transmembrane O- BMP Signalling Pathway arginine 2'-oxidoreductase: SPR D-glucopyranose hydrogen sulfide pyruvate α-D-glucosamine 2/4F2hc MAP kinase cascade S-adenosylmethionine amidinotransferase: creatine kinase: CKB histidine ornithine [methylmalonyl- peroxidase: thiouridine in tRNA OTC cys SAT1 decarboxylase: dehydrogenase: dopamine serine (R)-lipoate thioredoxin acyl carrier (6R)-L-erythro-5,6,7,8- all-trans-retinal pyridoxine-5'- pyridoxine-5'- 6-phosphate synthase: ASS1 PAPS oxidase: methyltransferase: Lymphocyte decarboxylase decarboxylase: + 10 L-homocysteine cys 6-phosphate arg complex arg GATM creatine kinase: CKM CKB decarboxylase: decarboxylase: lipoyl-adenylate reductase: CoA mutase] GPX7 NAD a 5,10- an N - phosphate phosphate transketolase: glucose-6- L-citrulline Diamine GAD1 ALDH2 MAOA 3-O-sulfate LRTOMT hydroxymethyltransferase: antigen 86 AZIN2 protein activation tetrahydrobiopterin dehydrogenase: pyridoxal guanidinoacetate HDC ODC1 methylenetetrahydrofolate TKT phosphate 1- cys L-homocysteine acetyltransferase 4-acetamidobutanal Glucosamine- SHMT1 BMP type II receptor creatine kinase: CKM synthase: LIPT1 TXNRD3 ALDH1A3 formyltetrahydrofolate oxidase: oxidase: kinase: sulfite β L-cystathionine activated Raf1 complex dAdoMet spermidine agmatine histamine putrescine lanthionine - 4-aminobutanoate [+ 3 isozymes] an apo acyl- PNPO PNPO dehydrogenase: synthase: CTH 1: SAT1 dehydrogenase: 6-phosphate serine guanidinoacetate N- creatine kinase: [(R)-lipoyl]adenylate folylpolyglutamate PDXK D-sedoheptulose D-glyceraldehyde synthase: CBS homocysteine cysteine 3,4-dihydroxyphenylacetaldehyde 3-methoxytyramine Ligand Trap:BMP2 BMP type I receptor G6PD isomerase Sulfate carrier protein all-trans-retinoate 6-phospho cystathionine β- Diamine ALDH3A2 hydroxymethyltransferase: sulfate sulfate methyltransferase: agmatinase: CKMT1A CKMT1A glutathione synthase: FPGS 7-phosphate 3-phosphate β lanthionine desulfhydrase: desulfhydrase: 4-aminobutyrate ω sulfite thiosulfate L-serine - L-homolanthionine 1: GNPDA1 transporter spermine synthase: SMS AGMAT N -phosphocreatine lipoyltransferase: 4'-phosphopantetheinyl D-glucono- synthase: CBS acetyltransferase aminotransferase: [+ 4 isozymes] SHMT2 GAMT a 5,10- an N 10 - oxidase: sulfurtransferase: synthase: CBS synthase: CTH CTH CTH synthase: CTH 3,4-dihydroxyphenylacetaldehyde 11-cis-retinal an 11-cis-retinal-[retinal-binding protein] transferase: AASDHPPT PLP 1,5-lactone 2: SAT2 Glucosamine- sodium coupled BMP-2 LIPT1 a reduced Other ketogenesis transaldolase: ABAT dehydrogenase: ALDH3A2 a phosphorylated a holo acyl- methylenetetrahydrofolate formyltetrahydrofolate SUOX TST 4-acetamidobutanoate ser aspartate plasma BMP receptor complex creatine putrescine thioredoxin malate- 6-phosphogluconolactonase: 6-phosphate a [lipoyl-carrier protein]- TALDO1 1 succinate (3,4- glu glu MAP2K mitogen-activated spermine carrier protein aspartate shuttle hydrogen sulfide N -acetylspermidine isomerase membrane N 6 -[(R)-lipoyl]-L-lysine PGLS semialdehyde dihydroxyphenyl) asp asp protein kinase kinase acetyl-CoA 2: GNPDA2 transport BMP ligand trap D-erythrose sulfate thiosulfate acetate F6P D-gluconate Peroxisomal N(1) succinate [multifunctional] BMP type II receptor asp Excitatory acetyl-CoA 4-phosphate 6-phosphate -acetyl-spermine/ semialdehyde F6P catechol O- BMP receptor complex glu glu acetyltransferase: aspartate 4-aminobutanoate amino acid transketolase: 6-phosphogluconate spermidine dehydrogenase: methyltransferase: asp asp ACAT1 aminotransferase: ALDH5A1 COMT transporter 3 TKT dehydrogenase: PGD oxidase: PAOX ERK ERK-P ERK-P GOT1 Excitatory Membrane Transmembrane O- acetoacetyl-CoA oxaloacetate D-glyceraldehyde D-ribulose succinate glu glu methyltransferase: amino acid 3-phosphate 5-phosphate primary amine asp asp BMP receptor complex malate oxidase: AOC3 LRTOMT transporter 4 hydroxymethylglutaryl-

CoA synthase: HMGCS2 dehydrogenase: putrescine homovanillate hENT4 Endofin MDH1

HMG-CoA malate R-Smad 1/5/8 P-R-Smad:Co-Smad P-R-Smad:Co-Smad dehydrogenase:

ERK-P hydroxymethylglutaryl- MDH2 glycerol-3- P2Y13 CoA lyase: HMGCL [+ 3 isozymes] phosphate shuttle BMP receptor complex Modified BMP type Co-Smad acetoacetate SKI SKI (S)-malate I receptor dimer DHAP Lymphocyte

antigen 75 3-hydroxybutyrate acetoacetate

dehydrogenase: decarboxylase glycerol-3- IGF-like BDH2 BMP receptor complex phosphate

family 3-hydroxybutyrate Modified R-Smad 1/5/8 acetone dehydrogenase: receptor 1 dehydrogenase: GPD1

BDH1 Serine SMURF I-Smad Phospho-R- Phospho-R- incorporator 3 Smad:Co-Smad (R)-3- sn-glycerol Smad:Co-Smad

hydroxybutanoate 3-phosphate I-Smad:phospho-

NLR family R-Smad

member X1 Respiration

BMP receptor complex I-Smad

Cold shock 2-oxoisovalerate decarboxylation to isobutanoyl-CoA 2-oxoglutarate decarboxylation to succinyl-CoA domain-

containing a [BCAA a [2-oxoglutarate protein E1 dehydrogenase 6 dehydrogenase E2 protein] N 3-methyl-2- 6 -lipoyl-L-lysine oxobutanoate E2 protein] N oxoglutarate

CK-1 dehydrogenase: -lipoyl-L-lysine dehydrogenase:

dihydrolipoyl BCKDHA BCKDHB dihydrolipoyl OGDH dehydrogenase: dehydrogenase: DLD DLD OR6-5 an [apo BCAA an [apo BCAA dehydrogenase a [2-oxoglutarate a [2-oxoglutarate dehydrogenase 6 dehydrogenase dehydrogenase 6 E2 protein] N -S-[2- 6 6 E2 protein] N E2 protein] N E2 protein] N -S- Olfactory methylpropanoyl]dihydrolipoyl- -dihydrolipoyl- -dihydrolipoyl- succinyldihydrolipoyl- receptor L-lysine L-lysine 52R1 L-lysine L-lysine

PSD-95 dihydrolipoyllysine- dihydrolipoyllysine-

residue (2- residue methylpropanoyl) succinyltransferase: ala transferase: DBT DLST ala val gln Olfactory a neutral leu phe ala asn chloride receptor sn-glycerol amino acid leu [+ 4 more] a xenobiotic a xenobiotic leu 3-(glutathion- a phospholipid ala thr [+ 3 more] 10AG1 myo-inositol myo-inositol 3-phosphate a nucleoside a nucleoside a bile acid arg ammonium ammonium all-trans a neutral tyr S-yl)-3- gly gly pro cys 4-aminobutanoate myo-inositol creatine thiamine a nucleoside a nucleoside ammonium a fatty acid dopamine L-ascorbate L-ascorbate amino acid an antigen an antigen D-glucose D-glucose methylhexan- glycine betaine -retinal Guanine a xenobiotic [+ 2 more] gly ser Cation Active Zinc finger peptide peptide 1-ol putative Na+ Serine/ Repressor V-type Caspase Zona nucleotide- Rho ATP- ATP-binding Sodium- Abhydrolase Sodium- PH and TNF Receptor Paired T cell channel Neuronal Apical CDC42 H + - Solute Neural cell HLA class I Neuronal AP-3 Signal breakpoint CCCH-type Probable L-type dependent TBC1 Calcium Ly6/PLAUR Probable threonine- Sodium/ Sodium/ Olfactory Olfactory Prostaglandin Immunoglobulin Ras-related Ras and Olfactory Olfactory Olfactory Cytoskeleton- Olfactory SLIT and of RNA proton Uncharacterized recruitment pellucida Transmembrane Interleukin- Olfactory Olfactory binding Heat shock guanine Olfactory Glycosylphosphatidylinositol- Immunoglobulin Olfactory Glycerol-3- binding cassette Equilibrative Equilibrative coupled Sodium/ Junctional y+LAT- Ammonium Ammonium Nuclear UL16- Olfactory domain- Anion coupled Immunoglobulin Olfactory SEC7 Leukotriene receptor- activity- immunoglobulin- receptor sperm- acetylcholine junction Olfactory Proline-rich Hydroxycarboxylic Relaxin small Protocadherin translocating carrier adhesion histocompatibility acetylcholine Actin-like complex transducer and Protocadherin cluster with G patch Alpha- phospholipid- Proteolipid amino acid Olfactory Glycosyltransferase neutral domain Protocadherin Transmembrane homeostasis domain- LanC-like G-protein protein Alpha- Olfactory V1aR Cnt-a2 Hmit myo-inositol myo-inositol CD83 Protein JTB Protocadherin-15 receptor Fz-6 receptor CT1 CD108 P2Y7 CD14 CD186 HZF7 E2 receptor Mitoguardin 2 hpHyde CD182 FMRP AS250 heavy protein Rab CD327 receptor THP HERV-K ROSP1 Agrin receptor receptor associated receptor NTRK-like CD64 polymerase III ATPase Ataxin-10 APR-3 TC1 RmP protein C15orf62, p190-B domain- T2R4 ITLN-1 sperm- pp55 7 superfamily Gravin BT 17 SLP-65 G1SYN receptor TREM-1 MCH-1R receptor protein G(I) 70 kDa Cubilin nucleotide CIB receptor MOAT-B HGL anchored high density OST181 kappa receptor ACTH-R LPA-5 phosphate CD243 cassette sub-family hENT3 nucleoside nucleoside CNT 2 ATB(0) neutral APT2 APT1 GLUT-7 hSGLT4 bile acid adhesion LAT2 2/4F2hc CK 2e CD241 transporter transporter MRP1 receptor NTB-A Retbindin FATP-6 hINO80 HPRAJ Claudin-19 PP-1B binding hLZTS2 Ficolin-1 VLDL-R receptor Annexin A3 containing exchange GPR73b DAT GlyT-1 GlyT-2 hPAT1 ASCT1 neutral BGT-1 Talin-2 hSVCT2 hSVCT1 BBM-I kappa receptor CD113 JP-4 domain- PAP OR1-26 Lactotransferrin B4 receptor 2 associated modifying like type 2 beta associated receptor component receptor 5L2 protein 12 acid receptor 3 receptor 2 effector beta-15 V-ATPase family 12 molecule L1- antigen, B receptor protein 6A subunit activator of alpha-4 region- domain- adducin transporting protein 2 transporter receptor 4L1 25 family member 3 amino acid family beta-9 protein 65 modulator containing protein 3 coupled phosphatase tectorin receptor 1F1 cotransporter cotransporter 2 6C4 1D5 EP2 subtype variable 3-66 Rab-3B interactor 1 51A7 2T35 5K4 protein 5 8K5 protein 4 transcription subunit S1- mitochondrial containing binding member 3 receptor C 52M1 6M1 /G(S)/G(O) protein 14 exchange 10J3 lipoprotein-binding protein 1 variable 2-40 4C5 transporter sub-family B member 6, transporter 2 transporter 1 amino acid cotransporter molecule-like complex Rh type B Rh type C coactivator 1 protein 6 11H4 protein transporter amino acid variable 1-27 6N2 containing factor 4 protein 2 receptor beta constant 2 protein subunit beta-2 1 homolog protein 1 subunit d2 member 2 like protein alpha chain subunit alpha-4 delta-1 transcription 3 related containing ATPase IA 1-like transporter member 24 protein 1 protein 6 receptor 153 6 regulatory MAF1 homolog like protein protein 11 protein 4 subunit factor 18 B member 5 mitochondrial transporter 2 FAM108B1 transporter 5 protein 1 subunit delta protein protein protein IMAA B(0)AT3 subunit 3 gamma-T2 an antigen an antigen 3-(glutathion- peptide peptide S-yl)-3- a phospholipid methylhexan-

1-ol

all-trans phe ala ala ala ala myo-inositol myo-inositol myo-inositol thiamine sn-glycerol a nucleoside a nucleoside a nucleoside a nucleoside a neutral a neutral D-glucose D-glucose a bile acid leu ammonium ammonium ammonium a fatty acid dopamine L-ascorbate L-ascorbate creatine leu gly gly pro thr val gln 4-aminobutanoate -retinal 3-phosphate a xenobiotic a xenobiotic a xenobiotic amino acid amino acid arg chloride tyr gly cys leu asn glycine betaine [+ 2 more] ser [+ 4 more] [+ 3 more]

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