Supplementary methods
Human lung tissues and tissue microarray (TMA)
All human tissues were obtained from the Lung Cancer Specialized Program of Research
Excellence (SPORE) Tissue Bank at the M.D. Anderson Cancer Center (Houston, TX). A
collection of 26 lung adenocarcinomas and 24 non-tumoral paired tissues were snap-frozen and
preserved in liquid nitrogen for total RNA extraction. For each tissue sample, the percentage of
malignant tissue was calculated and the cellular composition of specimens was determined by
histological examination (I.I.W.) following Hematoxylin-Eosin (H&E) staining. All malignant
samples retained contained more than 50% tumor cells.
Specimens resected from NSCLC stages I-IV patients who had no prior chemotherapy or
radiotherapy were used for TMA analysis by immunohistochemistry. Patients who had smoked
at least 100 cigarettes in their lifetime were defined as smokers. Samples were fixed in formalin,
embedded in paraffin, stained with H&E, and reviewed by an experienced pathologist (I.I.W.).
The 413 tissue specimens collected from 283 patients included 62 normal bronchial epithelia, 61 bronchial hyperplasias (Hyp), 15 squamous metaplasias (SqM), 9 squamous dysplasias (Dys), 26
carcinomas in situ (CIS), as well as 98 squamous cell carcinomas (SCC) and 141
adenocarcinomas. Normal bronchial epithelia, hyperplasia, squamous metaplasia, dysplasia, CIS,
and SCC were considered to represent different steps in the development of SCCs. All tumors
and lesions were classified according to the World Health Organization (WHO) 2004 criteria.
The TMAs were prepared with a manual tissue arrayer (Advanced Tissue Arrayer ATA100,
Chemicon International, Temecula, CA) using 1-mm-diameter cores in triplicate for tumors and
1.5 to 2-mm cores for normal epithelial and premalignant lesions.
Microarray data analysis
Raw data files and probe intensities of gene expression in cells of the human in vitro lung
carcinogenesis model were initially processed using Perfect Match by the positional-dependent
nearest-neighbor (PDNN) model matching observed probe signals and model-fitted values (1).
Gene features with differential expression of greater than 1.65 fold in any of the analyzed cells
compared to the NHBE cells were selected for further analysis (n=1221). Unsupervised
clustering by average linkage was performed using Cluster v2.11 and results were visualized
with TreeView programs (Michael Eisen Laboratory, Lawrence Berkeley National Laboratory
and University of California, Berkeley; http://rana.lbl.gov/EisenSoftware.htm). Self-organizing
map (SOM) analysis was then performed to identify clusters of genes displaying variation of
expression from the normal NHBE cells to the tumorigenic 1170-I cells. Differentially expressed
genes were also analyzed using Ingenuity Pathway Analysis® (http://www.ingenuity.com) to gain a pathway level of understanding of the modulated genes and identify significant gene- interaction networks. The cancer microarray database and integrated data-mining platform,
Oncomine (2) was utilized to analyze the expression of UBE2C in microarray databases of human lung carcinomas available on-line.
Raw data *.CEL files of the cells constituting the in vitro lung carcinogenesis model were also analyzed using the BRB-ArrayTools v.3.7.0 Beta developed by Dr. Richard Simon and
BRB-ArrayTools Development Team (Biometric Research Branch, National Cancer Institute;
http://linus.nci.nih.gov/BRB-ArrayTools.html) to develop a gene signature reflective of
differential and progressive gene expression among the in vitro model and to be analyzed in published data sets of NSCLC. Samples were normalized by Robust Multichip Average (RMA) normalization and genes were selected based on the criteria of at least 2-fold expression difference between the NHBE and 1170-I cells and with a p-value<0.001 of the univariate t-test
with permutation as well as displaying regular variation progressively across all cells of the in
vitro model (n=584). We analyzed raw microarray data files from several published NSCLC
cohort microarray databases to assess the expression of the 584 genes in clinical samples of
NSCLC. We used 361 adenocarcinomas from a recent multi-site blinded validation study by the
Director’s Challenge Consortium for the Molecular Classification of Lung Adenocarcinoma (3)
that were initially surgically resected in Memorial Sloan Kettering (n=104), University of
Michigan (n=178), and H. Lee Moffitt cancer center (n=79) (National Cancer Institute Cancer
Array database, experiment ID 1015945236141280:1 (https://caarraydb.nci.nih.gov/caarray). We excluded adenocarcinomas from the Dana Farber institute within the same report because of their reduced total gene expression levels as well as samples that were excluded in their original report
(3). We also utilized 125 unique adenocarcinomas from the cohort by Bhattacharjee et al. (4), 58 adenocarcinomas, and 53 SCCs from the published report by Bild et al. (5)
(http://data.cgt.duke.edu/oncogene.php), and 129 SCCs from the report by Raponi et al (6). All
NSCLC samples analyzed included only those that passed the quality checks in the original
published reports of the mentioned cohorts. In addition, each gene expression sample analyzed
represents one unique patient. All raw data files were imported and analyzed using the BRB-
ArrayTools v.3.7.0 Beta Genes were normalized independently by cohort. Common genes
present in all gene chip platforms (Affymetrix® HG-U133A, HG-U133 plus 2.0, and U95A) were identified using NetAffxTM from Affymetrix (http://www.affymetrix.com/analysis/index.affx) by searching corresponding gene annotations in the platforms. Prior to integration of the selected genes with the analyzed NSCLC datasets into a mixed cell line-clinical NSCLC samples dataset, gene expression ratios were normalized and median-centered separately on the different microarrays (7, 8). Hierarchical cluster analysis by average linkage was performed with Cluster
v2.11, Kaplan-Meier and log-rank test survival analyses based on 1170-I or NHBE clusters following hierarchical clustering analysis were performed using the R 2.6.0 statistical package
(http://www.r-project.org/). Expression of the group of six selected genes (UBE2C, MCM2,
MCM6, FEN1, TPX2, and SFN) was also analyzed in all of the aforementioned cohorts.
Hierarchical cluster analysis by average linkage of the data and log-rank statistics were then performed as described earlier to measure the survival differences among the identified patient clusters.
Quantitative Real-Time PCR
This method was performed using TaqMan® Gene Expression Assay (Applied
Biosystems, Foster City, CA) probes for UBE2C and for the housekeeping genes beta-actin
(ACTB), ribosomal protein large P0 (RPLP0), glucuronidase beta (GUSB), Transferrin receptor
(TFRC), 18S, 28S, Transactivating factor IID (TFIID) and Glyceraldehyde phosphate
dehydrogenase (GAPDH). All the real-time PCR reactions were carried out in duplicate using
TaqMan® Fast Universal PCR Master Mix and run on a 7500 fast Real-Time PCR System
according to the manufacturer’s instructions (Applied Biosystems). Normalization was assessed
by a combination of the 4 best housekeeping genes over all eight genes tested.
References
1. Zhang L, Miles MF, Aldape KD. A model of molecular interactions on short
oligonucleotide microarrays. Nat Biotechnol 2003;21:818-21.
2. Rhodes DR, Yu J, Shanker K, et al. ONCOMINE: a cancer microarray database and
integrated data-mining platform. Neoplasia 2004;6:1-6. 3. Shedden K, Taylor JM, Enkemann SA, et al. Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study. Nat Med 2008;14:822-7.
4. Bhattacharjee A, Richards WG, Staunton J, et al. Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc
Natl Acad Sci U S A 2001;98:13790-5.
5. Bild AH, Yao G, Chang JT, et al. Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature 2006;439:353-7.
6. Raponi M, Zhang Y, Yu J, et al. Gene expression signatures for predicting prognosis of squamous cell and adenocarcinomas of the lung. Cancer Res 2006;66:7466-72.
7. Kaposi-Novak P, Lee JS, Gomez-Quiroz L, Coulouarn C, Factor VM, Thorgeirsson SS.
Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype. J Clin Invest 2006;116:1582-95.
8. Lee JS, Heo J, Libbrecht L, et al. A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells. Nat Med 2006;12:410-6.
Supplementary figure 1 legend:
Increased UBE2C mRNA levels in NSCLC relative to adjacent normal lung tissue. A.
Normalized UBE2C mRNA expression levels in lung adenocarcinomas and SCCs relative to adjacent normal lung. UBE2C normalized expression levels were downloaded from four published microarray data sets available from the public microarray analysis platform, Oncomine.
The lead author of each published microarray cohort data is indicated in each panel. The number of analyzed tissues of adenocarcinomas, SCC, or normal lung is indicated below each bar. p- values represent statistical significance assessed by independent two-sided t-tests. B. UBE2C mRNA levels between 26 adenocarcinomas and 24 adjacent normal lung tissues analyzed by quantitative real-time PCR analysis. The p-value was determined by a two-sided t-test.
Supplementary figure 1
p < 0.001 p < 0.001 A B p < 0.001 2.0 2.4 Beer Su 2.0 1.6 2.0 1.6 1.2 1.6 1.2 0.8 0.8 1.2 0.4 0.4 0.0 0.0 0.8 N: 10 86 31 31 0.4 p < 0.001 p < 0.05 p < 0.001 0.0 3 1 UBE2C mRNA levels 2 Garber Garber 2 0 N: 24 26 1 1 alized UBE2C expression 0 -1 Normal ADC 0 -1 Lung -1 -2 -2 Norm Stearman -3 -3 -2 -4 N: 19 20 640 614 Normal Lung Normal Lung Normal Lung Lung ADC Lung ADC Lung SCC 1221 gene features UNIQID Gene Symbol 1007_s_at DDR1 1053_at RFC2 200000_s_at PRPF8 200028_s_at STARD7 200039_s_at PSMB2 200041_s_at BAT1 200064_at HSP90AB1 200072_s_at HNRNPM 200078_s_at ATP6V0B 200600_at MSN 200606_at DSP 200607_s_at RAD21 200614_at CLTC 200632_s_at NDRG1 200633_at RPS27A /// UBB /// UBC 200635_s_at PTPRF 200637_s_at PTPRF 200640_at YWHAZ 200641_s_at YWHAZ 200642_at SOD1 200644_at MARCKSL1 200648_s_at GLUL 200650_s_at LDHA 200655_s_at CALM1 /// CALM2 /// CALM3 200658_s_at PHB 200661_at CTSA 200665_s_at SPARC 200680_x_at HMGB1 200687_s_at SF3B3 200730_s_at PTP4A1 200732_s_at PTP4A1 200743_s_at TPP1 200754_x_at SFRS2 200757_s_at CALU 200776_s_at BZW1 /// BZW1L1 200779_at ATF4 200792_at XRCC6 200796_s_at MCL1 200798_x_at MCL1 200800_s_at HSPA1A /// HSPA1B 200806_s_at HSPD1 200807_s_at HSPD1 200824_at GSTP1 200839_s_at CTSB 200863_s_at RAB11A 200868_s_at RNF114 200872_at S100A10 200881_s_at DNAJA1 200886_s_at PGAM1 200897_s_at PALLD 200906_s_at PALLD 200907_s_at PALLD 200911_s_at TACC1 200916_at TAGLN2 200933_x_at RPS4X 200934_at DEK 200951_s_at CCND2 200956_s_at SSRP1 200965_s_at ABLIM1 200982_s_at ANXA6 200983_x_at CD59 200984_s_at CD59 200985_s_at CD59 201000_at AARS 201005_at CD9 201008_s_at TXNIP 201009_s_at TXNIP 201010_s_at TXNIP 201012_at ANXA1 201013_s_at PAICS 201015_s_at JUP 201037_at PFKP 201041_s_at DUSP1 201058_s_at MYL9 201061_s_at STOM 201066_at CYC1 201090_x_at TUBA1B 201092_at RBBP7 201095_at DAP 201107_s_at THBS1 201108_s_at THBS1 201112_s_at CSE1L 201119_s_at COX8A 201123_s_at EIF5A 201130_s_at CDH1 201131_s_at CDH1 201141_at GPNMB 201147_s_at TIMP3 201149_s_at TIMP3 201162_at IGFBP7 201168_x_at ARHGDIA 201201_at CSTB 201202_at PCNA 201231_s_at ENO1 201243_s_at ATP1B1 201251_at PKM2 201252_at PSMC4 201259_s_at SYPL1 201261_x_at BGN 201266_at TXNRD1 201267_s_at PSMC3 201286_at SDC1 201287_s_at SDC1 201288_at ARHGDIB 201289_at CYR61 201291_s_at TOP2A 201301_s_at ANXA4 201302_at ANXA4 201303_at EIF4A3 201306_s_at ANP32B 201312_s_at SH3BGRL 201313_at ENO2 201338_x_at GTF3A 201347_x_at GRHPR 201348_at GPX3 201349_at SLC9A3R1 201378_s_at UBAP2L 201381_x_at CACYBP 201387_s_at UCHL1 201390_s_at CSNK2B /// LY6G5B 201397_at PHGDH 201399_s_at TRAM1 201400_at PSMB3 201420_s_at WDR77 201425_at ALDH2 201426_s_at VIM 201433_s_at PTDSS1 201459_at RUVBL2 201468_s_at NQO1 201469_s_at SHC1 201476_s_at RRM1 201479_at DKC1 201487_at CTSC 201506_at TGFBI 201508_at IGFBP4 201525_at APOD 201555_at MCM3 201561_s_at CLSTN1 201577_at NME1 /// NME2 201587_s_at IRAK1 201590_x_at ANXA2 201594_s_at PPP4R1 201596_x_at KRT18 201599_at OAT 201616_s_at CALD1 201625_s_at INSIG1 201631_s_at IER3 201636_at FXR1 201639_s_at CPSF1 201641_at BST2 201645_at TNC 201650_at JUP /// KRT19 201656_at ITGA6 201663_s_at SMC4 201664_at SMC4 201666_at TIMP1 201700_at CCND3 201710_at MYBL2 201717_at MRPL49 201723_s_at GALNT1 201739_at SGK1 201756_at RPA2 201764_at TMEM106C 201774_s_at NCAPD2 201781_s_at AIP 201782_s_at AIP 201787_at FBLN1 /// LOC100133843 201798_s_at FER1L3 201804_x_at TBCB 201820_at KRT5 201839_s_at TACSTD1 201841_s_at HSPB1 201842_s_at EFEMP1 201850_at CAPG 201853_s_at CDC25B 201858_s_at SRGN 201864_at GDI1 201865_x_at NR3C1 201892_s_at IMPDH2 201896_s_at PSRC1 201897_s_at CKS1B 201909_at LOC100133662 /// RPS4Y1 201920_at SLC20A1 201930_at MCM6 201942_s_at CPD 201944_at HEXB 201946_s_at CCT2 201947_s_at CCT2 201952_at ALCAM 201968_s_at PGM1 201969_at NASP 201970_s_at NASP 202016_at MEST 202032_s_at MAN2A2 202037_s_at SFRP1 202075_s_at PLTP 202078_at COPS3 202084_s_at SEC14L1 202087_s_at CTSL1 202095_s_at BIRC5 202107_s_at MCM2 202144_s_at ADSL 202147_s_at IFRD1 202177_at GAS6 /// LOC100133684 202183_s_at KIF22 202189_x_at PTBP1 202193_at LIMK2 202196_s_at DKK3 202209_at LSM3 202227_s_at BRD8 202237_at NNMT 202238_s_at NNMT 202246_s_at CDK4 202263_at CYB5R1 202275_at G6PD 202283_at SERPINF1 202284_s_at CDKN1A 202286_s_at TACSTD2 202309_at MTHFD1 202332_at CSNK1E 202338_at TK1 202345_s_at FABP5 /// FABP5L2 /// FABP5L7 202352_s_at PSMD12 202363_at SPOCK1 202370_s_at CBFB 202380_s_at NKTR 202385_s_at TCOF1 202388_at RGS2 202395_at NSF 202421_at IGSF3 202431_s_at MYC 202458_at PRSS23 202471_s_at IDH3G 202483_s_at RANBP1 202489_s_at FXYD3 202503_s_at KIAA0101 202504_at TRIM29 202525_at PRSS8 202533_s_at DHFR 202565_s_at SVIL 202580_x_at FOXM1 202589_at TYMS 202597_at IRF6 202605_at GUSB 202610_s_at MED14 202617_s_at MECP2 202619_s_at PLOD2 202627_s_at SERPINE1 202633_at TOPBP1 202643_s_at TNFAIP3 202644_s_at TNFAIP3 202655_at ARMET 202672_s_at ATF3 202686_s_at AXL 202687_s_at TNFSF10 202688_at TNFSF10 202693_s_at STK17A 202705_at CCNB2 202719_s_at TES 202720_at TES 202727_s_at IFNGR1 202729_s_at LTBP1 202735_at EBP 202759_s_at AKAP2 /// PALM2 /// PALM2-AKAP2 202779_s_at LOC731049 /// UBE2S 202789_at PLCG1 202790_at CLDN7 202826_at SPINT1 202855_s_at SLC16A3 202856_s_at SLC16A3 202858_at U2AF1 202859_x_at IL8 202870_s_at CDC20 202887_s_at DDIT4 202911_at MSH6 202917_s_at S100A8 202931_x_at BIN1 202954_at UBE2C 202994_s_at FBLN1 202995_s_at FBLN1 202998_s_at ENTPD4 /// LOXL2 203022_at RNASEH2A 203037_s_at MTSS1 203038_at PTPRK 203041_s_at LAMP2 203046_s_at TIMELESS 203062_s_at MDC1 203065_s_at CAV1 203066_at GALNAC4S-6ST 203074_at ANXA8 /// ANXA8L1 /// ANXA8L2 203080_s_at BAZ2B 203113_s_at EEF1D 203167_at TIMP2 203172_at FXR2 203180_at ALDH1A3 203186_s_at S100A4 203214_x_at CDC2 203221_at TLE1 203234_at UPP1 203243_s_at PDLIM5 203252_at CDK2AP2 203254_s_at TLN1 203262_s_at FAM50A 203274_at F8A1 /// F8A2 /// F8A3 203276_at LMNB1 203287_at LAD1 203315_at NCK2 203323_at CAV2 203332_s_at INPP5D 203358_s_at EZH2 203381_s_at APOE 203394_s_at HES1 203409_at DDB2 203417_at MFAP2 203418_at CCNA2 203423_at RBP1 203430_at HEBP2 203432_at TMPO 203439_s_at STC2 203453_at SCNN1A 203476_at TPBG 203489_at SIVA1 203510_at MET 203535_at S100A9 203554_x_at PTTG1 203562_at FEZ1 203564_at FANCG /// VCP 203585_at ZNF185 203594_at RTCD1 203606_at NDUFS6 203695_s_at DFNA5 203696_s_at RFC2 203726_s_at LAMA3 203729_at EMP3 203744_at HMGB3 203747_at AQP3 203755_at BUB1B 203780_at MPZL2 203788_s_at SEMA3C 203797_at VSNL1 203821_at HBEGF 203917_at CXADR 203963_at CA12 203964_at NMI 203967_at CDC6 203968_s_at CDC6 203976_s_at CHAF1A 203978_at NUBP1 204019_s_at SH3YL1 204023_at RFC4 204026_s_at ZWINT 204033_at TRIP13 204050_s_at CLTA 204083_s_at TPM2 204092_s_at AURKA 204126_s_at CDC45L 204146_at RAD51AP1 204151_x_at AKR1C1 204201_s_at PTPN13 204204_at SLC31A2 204228_at PPIH 204233_s_at CHKA 204254_s_at VDR 204266_s_at CHKA 204267_x_at PKMYT1 204268_at S100A2 204279_at PSMB9 204295_at SURF1 204326_x_at MT1X 204341_at TRIM16 204351_at S100P 204379_s_at FGFR3 204388_s_at MAOA 204409_s_at EIF1AY 204441_s_at POLA2 204455_at DST 204466_s_at SNCA 204489_s_at CD44 204490_s_at CD44 204508_s_at CA12 204510_at CDC7 204531_s_at BRCA1 204532_x_at UGT1A1 /// UGT1A10 /// UGT1A4 /// UGT1A6 /// UGT1A8 /// UGT1A9 204560_at FKBP5 204566_at PPM1D 204602_at DKK1 204614_at SERPINB2 204617_s_at ACD 204620_s_at VCAN 204640_s_at SPOP 204649_at TROAP 204679_at KCNK1 204688_at SGCE 204709_s_at KIF23 204734_at KRT15 204745_x_at MT1G 204751_x_at DSC2 204752_x_at PARP2 204768_s_at FEN1 204825_at MELK 204858_s_at TYMP 204881_s_at UGCG 204948_s_at FST 204952_at LYPD3 204962_s_at CENPA 204989_s_at ITGB4 204990_s_at ITGB4 205014_at FGFBP1 205037_at RABL4 205047_s_at ASNS 205061_s_at EXOSC9 205067_at IL1B 205157_s_at KRT17 205167_s_at CDC25C 205176_s_at ITGB3BP 205185_at SPINK5 205229_s_at COCH 205239_at AREG /// AREGB 205321_at EIF2S3 205349_at GNA15 205376_at INPP4B 205436_s_at H2AFX 205463_s_at PDGFA 205476_at CCL20 205479_s_at PLAU 205483_s_at ISG15 205490_x_at GJB3 205519_at WDR76 205545_x_at DNAJC8 205547_s_at TAGLN 205595_at DSG3 205822_s_at HMGCS1 205847_at PRSS22 205905_s_at HLA-B /// HLA-C /// MICA /// MICB /// XXbac-BPG181B23.1 205909_at POLE2 205916_at S100A7 205961_s_at PSIP1 206008_at TGM1 206033_s_at DSC3 206066_s_at RAD51C 206094_x_at UGT1A1 /// UGT1A10 /// UGT1A3 /// UGT1A4 /// UGT1A5 /// UGT1A6 /// UGT1A7 /// UGT1A8 /// UGT1A9 206108_s_at SFRS6 206116_s_at TPM1 206156_at GJB5 206166_s_at CLCA2 206191_at ENTPD3 206247_at MICB 206284_x_at CLTB 206300_s_at PTHLH 206316_s_at KNTC1 206400_at LGALS7 /// LGALS7B 206421_s_at SERPINB7 206441_s_at COMMD4 206467_x_at RTEL1 /// TNFRSF6B 206499_s_at RCC1 /// SNHG3-RCC1 206550_s_at NUP155 206561_s_at AKR1B10 206562_s_at CSNK1A1 206582_s_at GPR56 206595_at CST6 206632_s_at APOBEC3B 206714_at ALOX15B 206770_s_at SLC35A3 206858_s_at HOXC4 /// HOXC6 206918_s_at CPNE1 206976_s_at HSPH1 207020_at HSF2BP 207039_at CDKN2A 207076_s_at ASS1 207081_s_at PI4KA 207121_s_at MAPK6 207126_x_at UGT1A1 /// UGT1A10 /// UGT1A4 /// UGT1A6 /// UGT1A8 /// UGT1A9 207165_at HMMR 207169_x_at DDR1 207332_s_at TFRC 207809_s_at ATP6AP1 207813_s_at FDXR 207826_s_at ID3 207828_s_at CENPF 207842_s_at CASC3 207876_s_at FLNC 207935_s_at KRT13 208029_s_at LAPTM4B 208078_s_at SNF1LK 208079_s_at AURKA 208084_at ITGB6 208107_s_at LOC81691 208336_s_at GPSN2 208370_s_at RCAN1 208436_s_at IRF7 208445_s_at BAZ1B 208539_x_at SPRR2B 208581_x_at MT1X 208596_s_at UGT1A1 /// UGT1A10 /// UGT1A3 /// UGT1A4 /// UGT1A5 /// UGT1A6 /// UGT1A7 /// UGT1A8 /// UGT1A9 208613_s_at FLNB 208637_x_at ACTN1 208650_s_at CD24 208651_x_at CD24 208668_x_at HMGN2 208683_at CAPN2 208687_x_at HSPA8 208690_s_at PDLIM1 208693_s_at GARS 208696_at CCT5 208699_x_at TKT 208700_s_at TKT 208702_x_at APLP2 208703_s_at APLP2 208712_at CCND1 208713_at HNRNPUL1 208718_at DDX17 208723_at USP11 208726_s_at EIF2S2 208729_x_at HLA-B 208749_x_at FLOT1 208773_s_at ANKHD1 /// ANKHD1-EIF4EBP3 /// EIF4EBP3 208775_at XPO1 208778_s_at TCP1 208779_x_at DDR1 208786_s_at MAP1LC3B 208790_s_at PTRF 208795_s_at MCM7 208819_at RAB8A 208850_s_at THY1 208867_s_at CSNK1A1 208887_at EIF3G 208891_at DUSP6 208892_s_at DUSP6 208893_s_at DUSP6 208922_s_at NXF1 208926_at NEU1 208937_s_at ID1 208939_at SEPHS1 208948_s_at STAU1 208949_s_at LGALS3 208963_x_at FADS1 /// FADS3 208965_s_at IFI16 208974_x_at KPNB1 208998_at UCP2 209016_s_at KRT7 209053_s_at WHSC1 209054_s_at WHSC1 209094_at DDAH1 209098_s_at JAG1 209099_x_at JAG1 209104_s_at NOLA2 209114_at TSPAN1 209118_s_at TUBA1A 209126_x_at KRT6B 209140_x_at HLA-B /// HLA-C /// MICA /// XXbac-BPG181B23.1 209160_at AKR1C3 209173_at AGR2 209186_at ATP2A2 209189_at FOS 209205_s_at LMO4 209210_s_at FERMT2 209211_at KLF5 209212_s_at KLF5 209230_s_at NUPR1 209260_at SFN 209275_s_at CLN3 209278_s_at TFPI2 209304_x_at GADD45B 209337_at PSIP1 209350_s_at D4S234E /// GPS2 209351_at KRT14 209386_at TM4SF1 209387_s_at TM4SF1 209408_at KIF2C 209409_at GRB10 209431_s_at PATZ1 209452_s_at VTI1B 209457_at DUSP5 209464_at AURKB 209503_s_at PSMC5 209507_at RPA3 209517_s_at ASH2L 209550_at NDN 209563_x_at CALM1 /// CALM2 /// CALM3 209581_at HRASLS3 209605_at TST 209642_at BUB1 209644_x_at CDKN2A 209674_at CRY1 209699_x_at AKR1C2 209709_s_at HMMR 209714_s_at CDKN3 209719_x_at SERPINB3 209720_s_at SERPINB3 209727_at GM2A 209771_x_at CD24 209772_s_at CD24 209773_s_at RRM2 209774_x_at CXCL2 209792_s_at KLK10 209800_at KRT16 209806_at HIST1H2BK 209832_s_at CDT1 209835_x_at CD44 209846_s_at BTN3A2 209849_s_at RAD51C 209863_s_at TP63 209872_s_at PKP3 209891_at SPC25 209946_at VEGFC 210052_s_at TPX2 210053_at TAF5 210095_s_at IGFBP3 210118_s_at IL1A 210139_s_at PMP22 210142_x_at FLOT1 210201_x_at BIN1 210212_x_at LOC100133946 /// MTCP1 210220_at FZD2 210241_s_at TP53TG1 210260_s_at TNFAIP8 210334_x_at BIRC5 210338_s_at HSPA8 210413_x_at SERPINB3 /// SERPINB4 210466_s_at SERBP1 210495_x_at FN1 210513_s_at VEGFA 210517_s_at AKAP12 210519_s_at NQO1 210559_s_at CDC2 210582_s_at LIMK2 210592_s_at SAT1 210609_s_at TP53I3 210658_s_at GGA2 210663_s_at KYNU 210664_s_at TFPI 210715_s_at SPINT2 210720_s_at NECAB3 210749_x_at DDR1 210764_s_at CYR61 210766_s_at CSE1L 210788_s_at DHRS7 210809_s_at POSTN 210817_s_at CALCOCO2 210820_x_at COQ7 210821_x_at CENPA 210830_s_at PON2 210869_s_at MCAM 210886_x_at TP53TG1 210916_s_at CD44 210933_s_at FSCN1 210950_s_at FDFT1 210983_s_at MCM7 210986_s_at TPM1 210987_x_at TPM1 210999_s_at GRB10 211002_s_at TRIM29 211043_s_at CLTB 211071_s_at MLLT11 211072_x_at TUBA1B 211162_x_at SCD 211194_s_at TP63 211240_x_at CTNND1 211272_s_at DGKA 211318_s_at RAE1 211340_s_at MCAM 211358_s_at CIZ1 211519_s_at KIF2C 211559_s_at CCNG2 211653_x_at AKR1C2 211657_at CEACAM6 211668_s_at PLAU 211676_s_at IFNGR1 211708_s_at SCD 211719_x_at FN1 211749_s_at VAMP3 211756_at PTHLH 211761_s_at CACYBP 211762_s_at KPNA2 /// LOC728860 211834_s_at TP63 211864_s_at FER1L3 211905_s_at ITGB4 211911_x_at FAM20B /// HLA-B /// HLA-C /// LOC730410 /// MICA /// XXbac-BPG181B23.1 211921_x_at PTMA 211926_s_at MYH9 211964_at COL4A2 211966_at COL4A2 211968_s_at HSP90AA1 212008_at UBXN4 212009_s_at STIP1 212014_x_at CD44 212021_s_at MKI67 212022_s_at MKI67 212034_s_at EXOC7 212063_at CD44 212070_at GPR56 212092_at PEG10 212097_at CAV1 212141_at MCM4 212142_at MCM4 212155_at RNF187 212169_at FKBP9 212190_at SERPINE2 212218_s_at FASN 212236_x_at KRT17 212242_at TUBA4A 212263_at QKI 212268_at SERPINB1 212279_at TMEM97 212281_s_at TMEM97 212282_at TMEM97 212285_s_at AGRN 212314_at KIAA0746 /// SERINC2 212328_at LIMCH1 212364_at MYO1B 212365_at MYO1B 212418_at ELF1 212430_at RBM38 212463_at CD59 212464_s_at FN1 212507_at TMEM131 212531_at LCN2 212552_at HPCAL1 212593_s_at PDCD4 212621_at TMEM194A 212657_s_at IL1RN 212702_s_at BICD2 212722_s_at JMJD6 212723_at JMJD6 212724_at RND3 212739_s_at NME4 212788_x_at FTL 212789_at NCAPD3 212801_at CIT 212832_s_at CKAP5 212859_x_at MT1E 212949_at NCAPH 212971_at CARS 212977_at CXCR7 212983_at HRAS 212992_at AHNAK2 212997_s_at TLK2 213008_at FANCI 213009_s_at TRIM37 213037_x_at STAU1 213083_at SLC35D2 213088_s_at DNAJC9 213110_s_at COL4A5 213113_s_at SLC43A3 213139_at SNAI2 213154_s_at BICD2 213175_s_at SNRPB 213240_s_at KRT4 213274_s_at CTSB 213275_x_at CTSB 213279_at DHRS1 213293_s_at TRIM22 213330_s_at STIP1 213334_x_at TREX2 /// UCHL5IP 213346_at C13orf27 213398_s_at C14orf124 213408_s_at PI4KA /// PI4KAP1 /// PI4KAP2 /// PI4KAP2 213421_x_at PRSS3 213428_s_at COL6A1 213446_s_at IQGAP1 213503_x_at ANXA2 213572_s_at SERPINB1 213587_s_at ATP6V0E2 213629_x_at MT1F 213682_at NUP50 213711_at KRT81 213716_s_at SECTM1 213787_s_at EBP 213798_s_at CAP1 213988_s_at SAT1 213992_at COL4A6 214040_s_at GSN 214086_s_at PARP2 214091_s_at GPX3 214095_at SHMT2 214096_s_at SHMT2 214141_x_at SFRS7 214164_x_at CA12 214211_at FTH1 214247_s_at DKK3 214259_s_at AKR7A2 214274_s_at ACAA1 214290_s_at HIST2H2AA3 /// HIST2H2AA4 214329_x_at TNFSF10 214431_at GMPS 214439_x_at BIN1 214580_x_at KRT6A /// KRT6B /// KRT6C 214581_x_at TNFRSF21 214599_at IVL 214696_at C17orf91 214701_s_at FN1 214710_s_at CCNB1 214853_s_at SHC1 214870_x_at LOC100132540 /// LOC100132620 /// LOC339047 /// LOC642799 /// NPIP 214875_x_at APLP2 214882_s_at SFRS2 214938_x_at HMGB1 214953_s_at APP 215001_s_at GLUL 215111_s_at TSC22D1 215116_s_at DNM1 215125_s_at UGT1A1 /// UGT1A10 /// UGT1A3 /// UGT1A4 /// UGT1A5 /// UGT1A6 /// UGT1A7 /// UGT1A8 /// UGT1A9 215177_s_at ITGA6 215223_s_at SOD2 215243_s_at GJB3 215388_s_at CFH /// CFHR1 215411_s_at TRAF3IP2 215509_s_at BUB1 215535_s_at AGPAT1 215707_s_at PRNP 215773_x_at PARP2 215867_x_at CA12 215891_s_at GM2A 216032_s_at ERGIC3 216237_s_at MCM5 216243_s_at IL1RN 216268_s_at JAG1 216379_x_at CD24 216442_x_at FN1 216526_x_at HLA-B /// HLA-C /// MICA /// XXbac-BPG181B23.1 216548_x_at HMG4L 216607_s_at CYP51A1 216862_s_at LOC100133946 /// MTCP1 216905_s_at ST14 216918_s_at DST 216969_s_at KIF22 217118_s_at C22orf9 217165_x_at MT1F 217202_s_at GLUL 217286_s_at NDRG3 217388_s_at KYNU 217728_at S100A6 217730_at TMBIM1 217732_s_at ITM2B 217733_s_at TMSB10 217734_s_at WDR6 217736_s_at EIF2AK1 217749_at COPG 217763_s_at RAB31 217767_at C3 217783_s_at YPEL5 217786_at PRMT5 217787_s_at GALNT2 217841_s_at PPME1 217853_at TNS3 217892_s_at LIMA1 217930_s_at TOLLIP 217957_at C16orf80 217960_s_at TOMM22 217969_at C11orf2 217973_at DCXR 217995_at SQRDL 217996_at PHLDA1 218000_s_at PHLDA1 218009_s_at PRC1 218014_at NUP85 218017_s_at HGSNAT 218035_s_at RBM47 218037_at FAM134A 218039_at NUSAP1 218061_at MEA1 218066_at SLC12A7 218069_at XTP3TPA 218080_x_at FAF1 218094_s_at DBNDD2 /// SYS1-DBNDD2 218103_at FTSJ3 218109_s_at MFSD1 218115_at ASF1B 218145_at TRIB3 218167_at AMZ2 218182_s_at CLDN1 218186_at RAB25 218189_s_at NANS 218261_at AP1M2 218264_at BCCIP 218269_at RNASEN 218280_x_at HIST2H2AA3 /// HIST2H2AA4 218308_at TACC3 218312_s_at ZSCAN18 218317_x_at GIYD1 /// GIYD2 218330_s_at NAV2 218332_at BEX1 218339_at MRPL22 218349_s_at ZWILCH 218350_s_at GMNN 218368_s_at TNFRSF12A 218383_at C14orf94 218391_at SNF8 218451_at CDCP1 218473_s_at GLT25D1 218480_at AGBL5 218482_at ENY2 218493_at C16orf33 218499_at RP6-213H19.1 218526_s_at RANGRF 218530_at FHOD1 218531_at TMEM134 218542_at CEP55 218586_at C20orf20 218638_s_at SPON2 218663_at NCAPG 218677_at S100A14 218740_s_at CDK5RAP3 218741_at CENPM 218755_at KIF20A 218757_s_at UPF3B 218768_at NUP107 218773_s_at MSRB2 218782_s_at ATAD2 218809_at PANK2 218810_at ZC3H12A 218826_at SLC35F2 218834_s_at TMEM132A 218845_at DUSP22 218854_at DSE 218856_at TNFRSF21 218866_s_at POLR3K 218875_s_at FBXO5 218883_s_at MLF1IP 218903_s_at OBFC2B 218953_s_at PCYOX1L 218960_at TMPRSS4 218963_s_at KRT23 218979_at RMI1 218990_s_at SPRR3 219024_at PLEKHA1 219058_x_at TINAGL1 219061_s_at LAGE3 219076_s_at PXMP2 219105_x_at ORC6L 219121_s_at RBM35A 219181_at LIPG 219241_x_at SSH3 219257_s_at SPHK1 219267_at GLTP 219270_at CHAC1 219305_x_at FBXO2 219329_s_at C2orf28 219412_at RAB38 219489_s_at NXN 219549_s_at RTN3 219550_at ROBO3 219554_at RHCG 219555_s_at CENPN 219569_s_at TMEM22 219588_s_at NCAPG2 219648_at MREG 219816_s_at RBM23 219832_s_at HOXC13 219918_s_at ASPM 219936_s_at GPR87 219978_s_at NUSAP1 219995_s_at ZNF750 220741_s_at PPA2 220746_s_at UIMC1 220755_s_at C6orf48 220892_s_at PSAT1 220935_s_at CDK5RAP2 220942_x_at FAM162A 220954_s_at PILRB 220987_s_at C11orf17 /// NUAK2 221004_s_at ITM2C 221269_s_at SH3BGRL3 221436_s_at CDCA3 221449_s_at ITFG1 221476_s_at RPL15 221488_s_at CUTA 221501_x_at LOC100132540 /// LOC100132620 /// LOC339047 /// NPIP 221521_s_at GINS2 221577_x_at GDF15 221591_s_at FAM64A 221664_s_at F11R 221666_s_at PYCARD 221675_s_at CHPT1 221677_s_at DONSON 221685_s_at CCDC99 221730_at COL5A2 221757_at PIK3IP1 221854_at PKP1 221875_x_at HLA-F 221898_at PDPN 222047_s_at ARS2 222108_at AMIGO2 222162_s_at ADAMTS1 266_s_at CD24 33322_i_at SFN 33323_r_at SFN 33646_g_at GM2A 35265_at FXR2 38037_at HBEGF 39248_at AQP3 39249_at AQP3 39402_at IL1B 40016_g_at LOC100128443 /// MAST4 40446_at PHF1 41469_at PI3 56197_at PLSCR3 57532_at DVL2 60474_at FERMT1 65588_at LOC388796 200660_at S100A11 200838_at CTSB 200880_at DNAJA1 200941_at HSBP1 200953_s_at CCND2 200999_s_at CKAP4 201109_s_at THBS1 201150_s_at TIMP3 201170_s_at BHLHB2 201185_at HTRA1 201207_at TNFAIP1 201236_s_at BTG2 201292_at TOP2A 201315_x_at IFITM2 201331_s_at STAT6 201368_at ZFP36L2 201416_at SOX4 201417_at SOX4 201432_at CAT 201466_s_at JUN 201474_s_at ITGA3 201579_at FAT 201667_at GJA1 201714_at TUBG1 201722_s_at GALNT1 201724_s_at GALNT1 201859_at SRGN 201890_at RRM2 201940_at CPD 201941_at CPD 201943_s_at CPD 201983_s_at EGFR 202007_at NID1 202028_s_at RPL38 202068_s_at LDLR 202117_at ARHGAP1 202181_at KIAA0247 202207_at ARL4C 202267_at LAMC2 202310_s_at COL1A1 202351_at ITGAV 202436_s_at CYP1B1 202474_s_at HCFC1 202534_x_at DHFR 202546_at VAMP8 202575_at CRABP2 202628_s_at SERPINE1 202668_at EFNB2 202711_at EFNB1 202744_at SLC20A2 202827_s_at MMP14 202828_s_at MMP14 202847_at PCK2 203021_at SLPI 203042_at LAMP2 203069_at SV2A 203159_at GLS 203213_at CDC2 203233_at IL4R 203238_s_at NOTCH3 203256_at CDH3 203303_at DYNLT3 203397_s_at GALNT3 203407_at PPL 203571_s_at C10orf116 203691_at PI3 203725_at GADD45A 203789_s_at SEMA3C 203910_at ARHGAP29 203939_at NT5E 204136_at COL7A1 204334_at KLF7 204359_at FLRT2 204363_at F3 204432_at SOX12 204470_at CXCL1 204542_at ST6GALNAC2 204610_s_at CCDC85B 204636_at COL17A1 204667_at FOXA1 204682_at LTBP2 204748_at PTGS2 204767_s_at FEN1 204855_at SERPINB5 204868_at ICT1 204887_s_at PLK4 204971_at CSTA 205000_at DDX3Y 205016_at TGFA 205046_at CENPE 205053_at PRIM1 205064_at SPRR1B 205412_at ACAT1 205453_at HOXB2 205680_at MMP10 205767_at EREG 205780_at BIK 206023_at NMU 206032_at DSC3 206102_at GINS1 206165_s_at CLCA2 206581_at BNC1 207517_at LAMC2 208025_s_at HMGA2 208153_s_at FAT2 208156_x_at EPPK1 208511_at PTTG3 208540_x_at S100A11P 208648_at VCP 208782_at FSTL1 208816_x_at ANXA2P2 208975_s_at KPNB1 209087_x_at MCAM 209122_at ADFP 209125_at KRT6A 209270_at LAMB3 209348_s_at MAF 209373_at MALL 209427_at SMTN 209477_at EMD 209482_at POP7 209718_at NCAPH2 209873_s_at PKP3 209885_at RHOD 209921_at SLC7A11 210020_x_at CALML3 211241_at ANXA2P3 211456_x_at MT1P2 211656_x_at HLA-DQB1 211986_at AHNAK 211998_at H3F3A /// H3F3B 212185_x_at MT2A 212192_at KCTD12 212204_at TMEM87A 212233_at MAP1B 212277_at MTMR4 212295_s_at SLC7A1 212543_at AIM1 212654_at TPM2 212737_at GM2A 212738_at ARHGAP19 212741_at MAOA 212798_s_at ANKMY2 212799_at STX6 212812_at --- 212815_at ASCC3 212836_at POLD3 212854_x_at NBPF10 212907_at SLC30A1 212952_at --- 213051_at ZC3HAV1 213238_at ATP10D 213258_at TFPI 213285_at TMEM30B 213338_at TMEM158 213507_s_at KPNB1 213520_at RECQL4 213524_s_at G0S2 213573_at --- 213574_s_at --- 213603_s_at RAC2 213680_at KRT6B 213757_at --- 213788_s_at FLJ35348 213789_at --- 213848_at --- 213869_x_at THY1 213924_at MPPE1 213943_at TWIST1 213979_s_at CTBP1 214041_x_at RPL37A 214097_at RPS21 214129_at PDE4DIP 214239_x_at PCGF2 214268_s_at MTMR4 214370_at S100A8 214426_x_at CHAF1A 214549_x_at SPRR1A 214620_x_at PAM 216272_x_at SYDE1 216336_x_at MT1E /// MT1H /// MT1M /// MT1P2 216594_x_at AKR1C1 217272_s_at SERPINB13 217279_x_at MMP14 217419_x_at AGRN 217527_s_at NFATC2IP 217528_at CLCA2 217744_s_at PERP 217762_s_at RAB31 217901_at DSG2 217997_at PHLDA1 217999_s_at PHLDA1 218275_at SLC25A10 218342_s_at ERMP1 218355_at KIF4A 218498_s_at ERO1L 218517_at PHF17 218585_s_at DTL 218644_at PLEK2 218902_at NOTCH1 219010_at C1orf106 219045_at RHOF 219099_at C12orf5 219177_at BXDC2 219258_at TIPIN 219392_x_at PRR11 219496_at ANKRD57 219646_at DEF8 219959_at MOCOS 221477_s_at SOD2 221484_at B4GALT5 221728_x_at XIST 221731_x_at VCAN 221822_at CCDC101 221832_s_at LUZP1 221954_at C20orf111 221988_at C19orf42 222037_at MCM4 35820_at GM2A 41660_at CELSR1 48808_at DHFR 301 unique genes up-regulated progressively in the in vitro model
UNIQID Gene symbol 214938_x_at HMGB1 204617_s_at ACD 209718_at NCAPH2 216272_x_at SYDE1 205412_at ACAT1 204752_x_at ADPRTL2 202144_s_at ADSL 210517_s_at AKAP12 201306_s_at ANP32B 200982_s_at ANXA6 210720_s_at APBA2BP 206632_s_at APOBEC3B 212738_at ARHGAP19 202655_at ARMET 222047_s_at ARS2 218115_at ASF1B 219918_s_at ASPM 209464_at AURKB 202686_s_at AXL 221484_at B4GALT5 200041_s_at BAT1 208445_s_at BAZ1B 218332_at BEX1 202931_x_at BIN1 202095_s_at BIRC5 219555_s_at BM039 204531_s_at BRCA1 202227_s_at BRD8 219177_at BRIX 212949_at BRRN1 209846_s_at BTN3A2 209642_at BUB1 203755_at BUB1B 218542_at C10orf3 213398_s_at C14orf124 218493_at C16orf33 221954_at C20orf111 218586_at C20orf20 218741_at C22orf18 221488_s_at C6orf82 213587_s_at C7orf32 218979_at C9orf76 207842_s_at CASC3 202370_s_at CBFB 203418_at CCNA2 214710_s_at CCNB1 202705_at CCNB2 221675_s_at CHPT1 212832_s_at ch-TOG 212801_at CIT 201896_s_at CKS1B 218875_s_at FBXO5 221004_s_at ITM2C 218517_at JADE1 205909_at POLE2 218866_s_at POLR3K 203213_at CDC2 202870_s_at CDC20 201853_s_at CDC25B 205167_s_at CDC25C 204126_s_at CDC45L 203967_at CDC6 204510_at CDC7 221436_s_at CDCA3 202246_s_at CDK4 218740_s_at CDK5RAP3 207039_at CDKN2A 209714_s_at CDKN3 209832_s_at CDT1 204962_s_at CENPA 205046_at CENPE 207828_s_at CENPF 203976_s_at CHAF1A 204050_s_at CLTA 200614_at CLTC 201774_s_at CNAP1 205229_s_at COCH 206441_s_at COMMD4 217749_at COPG 202078_at COPS3 210820_x_at COQ7 201119_s_at COX8 201639_s_at CPSF1 209674_at CRY1 201112_s_at CSE1L 202332_at CSNK1E 201390_s_at CSNK2B 217973_at DCXR 209094_at DDAH1 205000_at DDX3Y 200934_at DEK 202534_x_at DHFR 201479_at DKC1 200880_at DNAJA1 205545_x_at DNAJC8 213088_s_at DNAJC9 215116_s_at DNM1 203252_at DOC-1R 221677_s_at DONSON 201041_s_at DUSP1 57532_at DVL2 218391_at EAP30 203113_s_at EEF1D 204409_s_at EIF1AY 208726_s_at EIF2S2 208887_at EIF3S4 201313_at ENO2 203358_s_at EZH2 208963_x_at FADS1 218080_x_at FAF1 203564_at FANCG 204767_s_at FEN1 218530_at FHOD1 221591_s_at FLJ10156 213008_at FLJ10719 219392_x_at FLJ11029 205519_at FLJ12973 219588_s_at FLJ20311 221685_s_at FLJ20364 219258_at FLJ20516 218480_at FLJ21839 208749_x_at FLOT1 202580_x_at FOXM1 218103_at FTSJ3 201636_at FXR1 210220_at FZD2 205483_s_at G1P2 210658_s_at GGA2 218350_s_at GMNN 214431_at GMPS 209350_s_at GPS2 208336_s_at GPSN2 217957_at GTL3 205436_s_at H2AFX 218663_at HCAP-G 202474_s_at HCFC1 216526_x_at HLA-C 200680_x_at HMGB1 208668_x_at HMGN2 207165_at HMMR 212552_at HPCAL1 209581_at HRASLS3 217736_s_at HRI 200807_s_at HSPD1 201315_x_at IFITM2 210095_s_at IGFBP3 201892_s_at IMPDH2 201587_s_at IRAK1 208436_s_at IRF7 201090_x_at K-ALPHA-1 212789_at KIAA0056 202503_s_at KIAA0101 206102_at KIAA0186 212621_at KIAA0286 212328_at KIAA1102 218755_at KIF20A 202183_s_at KIF22 204709_s_at KIF23 209408_at KIF2C 218355_at KIF4A 218883_s_at KLIP1 213507_s_at KPNB1 213711_at KRTHB1 203276_at LMNB1 218167_at LOC51321 213346_at LOC93081 212279_at MAC30 208773_s_at MASK 202107_s_at MCM2 201555_at MCM3 212141_at MCM4 216237_s_at MCM5 201930_at MCM6 203062_s_at MDC1 218061_at MEA 204825_at MELK 218903_s_at MGC2731 201764_at MGC5576 205905_s_at MICA 206247_at MICB 212021_s_at MKI67 218339_at MRPL22 201717_at MRPL49 202911_at MSH6 202309_at MTHFD1 212277_at MTMR4 201710_at MYBL2 218189_s_at NANS 201969_at NASP 203606_at NDUFS6 202380_s_at NKTR 203964_at NMI 202237_at NNMT 201865_x_at NR3C1 202395_at NSF 218768_at NUP107 206550_s_at NUP155 213682_at NUP50 218039_at NUSAP1 219105_x_at ORC6L 218809_at PANK2 201202_at PCNA 218014_at PCNT1 214129_at PDE4DIP 221521_s_at Pfs2 207081_s_at PIK4CA 204146_at PIR51 204267_x_at PKMYT1 209210_s_at PLEKHC1 204887_s_at PLK4 217841_s_at PME-1 205061_s_at PMSCL1 204441_s_at POLA2 212836_at POLD3 200661_at PPGB 204228_at PPIH 218009_s_at PRC1 201858_s_at PRG1 218782_s_at PRO2000 200000_s_at PRPF8 205961_s_at PSIP1 200039_s_at PSMB2 204279_at PSMB9 201267_s_at PSMC3 201252_at PSMC4 209503_s_at PSMC5 212722_s_at PTDSR 203554_x_at PTTG1 212263_at QKI 208819_at RAB8A 205037_at RABL4 206066_s_at RAD51C 211318_s_at RAE1 218585_s_at RAMP 219550_at RBIG1 206918_s_at RBM12 213520_at RECQL4 1053_at RFC2 204023_at RFC4 218269_at RNASE3L 203022_at RNASEH2A 212430_at RNPC1 201756_at RPA2 209507_at RPA3 209482_at RPP20 214097_at RPS21 201909_at RPS4Y 201476_s_at RRM1 201890_at RRM2 219549_s_at RTN3 201459_at RUVBL2 216032_s_at SDBCAG84 204432_at SOX12 202338_at TK1 202589_at TYMS 202858_at U2AF1 200633_at UBB 202954_at UBE2C 202779_s_at UBE2S 200687_s_at SF3B3 206108_s_at SFRS6 204688_at SGCE 211761_s_at SIP 218275_at SLC25A10 201663_s_at SMC4L1 213175_s_at SNRPB 209891_at Spc25 204640_s_at SPOP 200028_s_at STARD7 208948_s_at STAU 204092_s_at STK6 204295_at SURF1 203069_at SV2A 200911_s_at TACC1 218308_at TACC3 202385_s_at TCOF1 210664_s_at TFPI 208850_s_at THY1 203046_s_at TIMELESS 203167_at TIMP2 212997_s_at TLK2 203432_at TMPO 201291_s_at TOP2A 202633_at TOPBP1 204083_s_at TPM2 210052_s_at TPX2 213334_x_at TREX2 213009_s_at TRIM37 204033_at TRIP13 204649_at TROAP 201714_at TUBG1 213943_at TWIST1 201266_at TXNRD1 201387_s_at UCHL1 204881_s_at UGCG 210053_at USMG5 208723_at USP11 209053_s_at WHSC1 208775_at XPO1 209431_s_at ZNF278 204026_s_at ZWINT 358 unique genes down-regulated progressively in the in vitro model
UNIQID Gene symbol 211456_x_ MT1P2 212812_at 212812_at 216379_x_ CD24 217202_s_ GLUL 200965_s_ ABLIM1 214274_s_ ACAA1 222162_s_ ADAMTS1 209173_at AGR2 212543_at AIM1 206561_s_ AKR1B10 204151_x_ AKR1C1 209699_x_ AKR1C2 209160_at AKR1C3 203180_at ALDH1A3 201425_at ALDH2 206714_at ALOX15B 222108_at AMIGO2 201012_at ANXA1 208816_x_ ANXA2 201301_s_ ANXA4 203074_at ANXA8 215867_x_ AP1G1 218261_at AP1M2 208702_x_ APLP2 201525_at APOD 203381_s_ APOE 214953_s_ APP 203747_at AQP3 205239_at AREG 202207_at ARL7 221666_s_ ASC 201243_s_ ATP1B1 203080_s_ BAZ2B 209373_at BENE 201170_s_ BHLHB2 212702_s_ BICD2 206581_at BNC 204455_at BPAG1 219099_at C12orf5 212992_at C14orf78 60474_at C20orf42 204952_at C4.4A 215411_s_ C6orf4 203963_at CA12 201616_s_ CALD1 210020_x_ CALML3 208683_at CAPN2 201432_at CAT 205476_at CCL20 208712_at CCND1 200951_s_ CCND2 211559_s_ CCNG2 208650_s_ CD24 204489_s_ CD44 200983_x_ CD59 201005_at CD9 219305_x_ FBXO2 217787_s_ GALNT2 203397_s_ GALNT3 204989_s_ ITGB4 208084_at ITGB6 217732_s_ ITM2B 214599_at IVL 209098_s_ JAG1 210830_s_ PON2 210809_s_ POSTN 217730_at PP1201 201130_s_ CDH1 203256_at CDH3 211657_at CEACAM6 41660_at CELSR1 206165_s_ CLCA2 218182_s_ CLDN1 202790_at CLDN7 206284_x_ CLTB 212977_at CMKOR1 204636_at COL17A1 213110_s_ COL4A5 213992_at COL4A6 221730_at COL5A2 204136_at COL7A1 201940_at CPD 202575_at CRABP2 204620_s_ CSPG2 204971_at CSTA 201201_at CSTB 211240_x_ CTNND1 200838_at CTSB 201487_at CTSC 204470_at CXCL1 202887_s_ DDIT4 1007_s_at DDR1 203695_s_ DFNA5 211272_s_ DGKA 213279_at DHRS1 212204_at DKFZP564G2022 202196_s_ DKK3 204751_x_ DSC2 206032_at DSC3 208370_s_ DSCR1 205595_at DSG3 200606_at DSP 203821_at DTR 218845_at DUSP22 208891_at DUSP6 213848_at DUSP7 204858_s_ ECGF1 202711_at EFNB1 201983_s_ EGFR 205321_at EIF2S3 213757_at EIF5A 212418_at ELF1 206191_at ENTPD3 217892_s_ EPLIN 208156_x_ EPPK1 205767_at EREG 218498_s_ ERO1L 203780_at EVA1 221664_s_ F11R 204363_at F3 202345_s_ FABP5 201579_at FAT 208153_s_ FAT2 201798_s_ FER1L3 203562_at FEZ1 204379_s_ FGFR3 212169_at FKBP9 219648_at FLJ10116 219010_at FLJ10901 219995_s_ FLJ13841 219121_s_ FLJ20171 218035_s_ FLJ20273 219496_at FLJ21870 218810_at FLJ23231 218017_s_ FLJ32731 204359_at FLRT2 214701_s_ FN1 209189_at FOS 204667_at FOXA1 204948_s_ FST 202489_s_ FXYD3 203066_at GALNAC4S-6ST 201722_s_ GALNT1 201667_at GJA1 205490_x_ GJB3 206156_at GJB5 219267_at GLTP 200648_s_ GLUL 209727_at GM2A 205349_at GNA15 206582_s_ GPR56 219936_s_ GPR87 201348_at GPX3 214040_s_ GSN 200824_at GSTP1 203430_at HEBP2 212815_at HELIC1 215388_s_ HFL1 209806_at HIST1H2BK 214290_s_ HIST2H2AA 211656_x_ HLA-DQB1 216548_x_ HMG4L 208025_s_ HMGA2 203744_at HMGB3 207020_at HSF2BP 218834_s_ HSPA5BP1 201841_s_ HSPB1 201631_s_ IER3 208965_s_ IFI16 202727_s_ IFNGR1 202421_at IGSF3 210118_s_ IL1A 205067_at IL1B 212657_s_ IL1RN 203233_at IL4R 202859_x_ IL8 205376_at INPP4B 213446_s_ IQGAP1 202597_at IRF6 201474_s_ ITGA3 201656_at ITGA6 202351_at ITGAV 201015_s_ JUP 204679_at KCNK1 212192_at KCTD12 40016_g_aKIAA0303 202117_at KIAA0652 217118_s_ KIAA0930 200897_s_ KIAA0992 209211_at KLF5 204334_at KLF7 209792_s_ KLK10 207935_s_ KRT13 209351_at KRT14 204734_at KRT15 209800_at KRT16 205157_s_ KRT17 213240_s_ KRT4 201820_at KRT5 209125_at KRT6A 209126_x_ KRT6B 210663_s_ KYNU 203287_at LAD1 203726_s_ LAMA3 209270_at LAMB3 202267_at LAMC2 203041_s_ LAMP2 212531_at LCN2 219058_x_ LCN7 202068_s_ LDLR 206400_at LGALS7 203243_s_ LIM 202193_at LIMK2 219181_at LIPG 213285_at LOC161291 202729_s_ LTBP1 204682_at LTBP2 209348_s_ MAF 204388_s_ MAOA 207121_s_ MAPK6 200796_s_ MCL1 203417_at MFAP2 221757_at MGC17330 205680_at MMP10 202827_s_ MMP14 213924_at MPPE1 218499_at MST4 213629_x_ MT1F 204745_x_ MT1G 204326_x_ MT1X 212185_x_ MT2A 203037_s_ MTSS1 202431_s_ MYC 212364_at MYO1B 203315_at NCK2 209550_at NDN 200632_s_ NDRG1 218902_at NOTCH1 203238_s_ NOTCH3 203939_at NT5E 201599_at OAT 212593_s_ PDCD4 208690_s_ PDLIM1 217744_s_ PERP 217996_at PHLDA1 203691_at PI3 221854_at PKP1 209872_s_ PKP3 205479_s_ PLAU 218644_at PLEK2 219024_at PLEKHA1 56197_at PLSCR3 201594_s_ PPP4R1 215707_s_ PRNP 201185_at PRSS11 205847_at PRSS22 202525_at PRSS8 204748_at PTGS2 206300_s_ PTHLH 200730_s_ PTP4A1 204201_s_ PTPN13 200637_s_ PTPRF 203038_at PTPRK 200863_s_ RAB11A 218186_at RAB25 217763_s_ RAB31 219412_at RAB38 203423_at RBP1 202388_at RGS2 219554_at RHCG 200872_at S100A10 200660_at S100A11 208540_x_ S100A11P 218677_at S100A14 203186_s_ S100A4 217728_at S100A6 205916_at S100A7 202917_s_ S100A8 203535_at S100A9 204351_at S100P 218854_at SART2 210592_s_ SAT 201286_at SDC1 203788_s_ SEMA3C 212268_at SERPINB1 221477_s_ SOD2 201416_at SOX4 201149_s_ TIMP3 217272_s_ SERPINB13 204614_at SERPINB2 209719_x_ SERPINB3 210413_x_ SERPINB4 204855_at SERPINB5 206421_s_ SERPINB7 202627_s_ SERPINE1 202283_at SERPINF1 209260_at SFN 202037_s_ SFRP1 201739_at SGK 201312_s_ SH3BGRL 221269_s_ SH3BGRL3 204019_s_ SH3YL1 204542_at SIAT7B 202744_at SLC20A2 204204_at SLC31A2 218826_at SLC35F2 203021_at SLPI 213139_at SNAI2 204466_s_ SNCA 219257_s_ SPHK1 205185_at SPINK5 202826_at SPINT1 202363_at SPOCK 214549_x_ SPRR1A 205064_at SPRR1B 208539_x_ SPRR2B 218990_s_ SPRR3 202458_at SPUVE 217995_at SQRDL 219241_x_ SSH-3 216905_s_ ST14 202693_s_ STK17A 201061_s_ STOM 212799_at STX6 202565_s_ SVIL 201259_s_ SYPL 221898_at T1A-2 202286_s_ TACSTD2 202720_at TES 205016_at TGFA 201506_at TGFBI 206008_at TGM1 201107_s_ THBS1 209386_at TM4SF1 218960_at TMPRSS4 217733_s_ TMSB10 201645_at TNC 201207_at TNFAIP1 202643_s_ TNFAIP3 218368_s_ TNFRSF12A 214581_x_ TNFRSF21 202687_s_ TNFSF10 217930_s_ TOLLIP 210241_s_ TP53AP1 209863_s_ TP73L 203476_at TPBG 202504_at TRIM29 209114_at TSPAN-1 212008_at UBXD2 204532_x_ UGT1A10 211749_s_ VAMP3 202546_at VAMP8 210513_s_ VEGF 209946_at VEGFC 203797_at VSNL1 221728_x_ XIST 200640_at YWHAZ 201368_at ZFP36L2 List of 584 genes
UNIQID Gene symbol NHBE NHBE 1170-I 1170-I 202238_s_ NNMT 5.29584 4.9161 10.48916 10.47063 201858_s_ SRGN 4.6506 4.56903 10.04741 9.85661 201909_at RPS4Y1 5.99604 6.00787 10.6894 10.65168 213711_at KRT81 5.99038 5.96788 10.50232 10.32868 201291_s_ TOP2A 5.70258 5.41762 10.08766 9.49203 209714_s_ CDKN3 5.89311 5.52785 9.64152 9.6531 209337_at PSIP1 5.96346 6.27739 10.01073 9.83109 201387_s_ UCHL1 6.99494 7.00129 10.73963 10.85012 218755_at KIF20A 5.855 6.15602 9.78162 9.66608 202870_s_ CDC20 6.69627 6.90821 10.41349 10.41872 207165_at HMMR 5.82082 5.9652 9.45646 9.27789 218039_at NUSAP1 6.9429 7.09576 10.57265 10.41237 208079_s_ AURKA 6.29679 6.40948 9.91171 9.69634 212328_at LIMCH1 3.79854 3.89338 7.40459 7.13302 202954_at UBE2C 7.55851 7.41853 10.86479 10.82996 218332_at BEX1 6.44148 6.42309 9.88117 9.69059 219918_s_ ASPM 5.28862 5.34324 8.7263 8.57064 209642_at BUB1 5.66275 5.53486 8.88674 8.68235 214710_s_ CCNB1 6.94015 7.0748 10.16913 10.0888 209408_at KIF2C 6.95833 6.96246 10.15248 9.97525 201774_s_ NCAPD2 5.96279 5.91167 8.95279 8.99555 202705_at CCNB2 7.03059 6.84297 10.06553 9.87355 202107_s_ MCM2 6.78931 6.84267 9.84501 9.80419 207828_s_ CENPF 6.28357 6.241 9.2663 9.25724 202095_s_ BIRC5 6.50116 6.41051 9.3914 9.46126 212621_at KIAA0286 5.56223 5.85274 8.73945 8.57532 202686_s_ AXL 7.28221 7.36488 10.17939 10.28987 218009_s_ PRC1 6.31518 6.79019 9.51753 9.32408 212281_s_ TMEM97 5.9204 6.1245 8.88078 8.87782 204767_s_ FEN1 6.01217 6.31426 9.01338 9.01853 201313_at ENO2 5.58649 5.2783 8.47225 8.03074 204033_at TRIP13 6.93197 7.06294 9.93131 9.65661 218308_at TACC3 6.13579 6.48094 9.19284 8.98685 202580_x_ FOXM1 6.48736 6.39606 9.19381 9.23036 209773_s_ RRM2 8.56545 8.52748 11.32065 11.29004 207039_at CDKN2A 5.82873 6.18435 8.77213 8.7197 210559_s_ CDC2 7.36906 7.40065 10.07504 10.15751 216237_s_ MCM5 5.88506 6.18848 8.7374 8.73185 200880_at DNAJA1 7.32016 7.26585 10.08778 9.81537 218355_at KIF4A 5.63595 6.00485 8.41328 8.53579 203554_x_ PTTG1 9.06361 9.07869 11.61948 11.70968 218663_at NCAPG 4.86487 4.88114 7.56264 7.34558 202338_at TK1 6.75829 7.01819 9.41703 9.51793 203755_at BUB1B 6.14325 6.11144 9.03416 8.35966 212022_s_ MKI67 6.51334 6.13525 8.86933 8.89086 202534_x_ DHFR 5.43262 5.45768 8.27966 7.71627 218585_s_ DTL 5.58936 5.87779 8.48083 8.06151 202589_at TYMS 8.66466 8.74335 11.2602 11.21259 202779_s_ UBE2S 8.62346 8.88 11.34133 11.21505 218350_s_ GMNN 6.04796 6.62176 8.98438 8.71024 204083_s_ TPM2 6.9568 7.15936 9.69776 9.40389 201663_s_ SMC4 6.1911 6.36756 8.82979 8.71112 209581_at HRASLS3 6.18167 6.42822 8.87772 8.66105 205046_at CENPE 5.98696 6.29317 8.61613 8.58583 203967_at CDC6 4.27673 4.15974 6.72476 6.61908 212552_at HPCAL1 7.67391 7.80001 10.23899 10.07905 204962_s_ CENPA 6.19743 6.16452 8.70788 8.48882 221677_s_ DONSON 5.23622 5.3902 7.89273 7.5612 210052_s_ TPX2 7.38264 7.45135 9.81309 9.83591 201970_s_ NASP 7.02804 7.01239 9.40378 9.43769 201266_at TXNRD1 7.55269 7.73147 9.93501 10.14447 214097_at RPS21 7.52674 7.89019 10.11776 10.06178 206108_s_ SFRS6 5.58805 5.72017 8.03082 8.01972 203022_at RNASEH2A 7.31586 7.35768 9.77697 9.63139 218542_at CEP55 6.1323 6.069 8.71267 8.19556 209464_at AURKB 6.05333 6.00386 8.48122 8.24073 222037_at MCM4 5.73347 5.88537 8.19113 8.08262 202227_s_ BRD8 6.25045 6.50367 8.81779 8.54401 204146_at RAD51AP1 4.68035 4.84926 7.25473 6.81755 221436_s_ CDCA3 6.14733 5.89605 8.4034 8.16958 203418_at CCNA2 6.58062 6.51267 8.8804 8.71035 204023_at RFC4 7.37809 7.32641 9.60522 9.58442 203276_at LMNB1 4.8238 4.88744 7.19534 6.95592 201710_at MYBL2 7.83597 8.01649 10.11557 10.15502 214439_x_ BIN1 7.09515 7.34277 9.48634 9.34933 201202_at PCNA 7.71881 7.82385 10.12291 9.7889 219258_at TIPIN 5.10005 5.06576 7.51439 7.00453 221521_s_ GINS2 5.80238 5.99782 8.16851 7.95321 205229_s_ COCH 4.23708 4.30496 6.52444 6.28648 201555_at MCM3 7.4364 7.56023 9.61138 9.57589 210766_s_ CSE1L 8.26748 8.45593 10.53936 10.35427 203976_s_ CHAF1A 5.72657 5.98714 7.95843 7.92244 206632_s_ APOBEC3B 4.72848 4.8887 7.12964 6.65284 218782_s_ ATAD2 6.15161 5.96878 8.20406 8.07783 206247_at MICB 6.58851 6.23054 8.57313 8.39613 203432_at TMPO 7.47211 7.52516 9.6479 9.47511 210220_at FZD2 4.9123 5.04128 7.06556 7.0081 202911_at MSH6 7.05715 7.28132 9.19224 9.22823 212723_at JMJD6 6.21568 6.47089 8.43329 8.30323 202503_s_ KIAA0101 8.34723 8.60063 10.46348 10.52473 204510_at CDC7 5.28305 5.35059 7.32198 7.32436 201930_at MCM6 7.38982 7.44643 9.49836 9.33126 203062_s_ MDC1 5.48895 5.60728 7.6845 7.391 201714_at TUBG1 8.37128 8.47101 10.4332 10.3841 204688_at SGCE 5.74808 6.11236 8.06414 7.76279 218014_at NUP85 7.23574 7.37231 9.3585 9.20818 201896_s_ PSRC1 6.11479 5.98385 8.04423 7.99867 209210_s_ PLEKHC1 6.60944 6.80545 8.77328 8.58383 219555_s_ CENPN 7.07354 7.05713 9.19914 8.87024 206550_s_ NUP155 6.17058 6.68104 8.54228 8.2412 218115_at ASF1B 7.26031 7.27682 9.21799 9.22614 208850_s_ THY1 6.2572 6.16014 8.19193 8.11133 218586_at C20orf20 5.7716 6.02001 7.94922 7.72369 219549_s_ RTN3 7.42512 7.55637 9.44606 9.40646 202183_s_ KIF22 5.71121 5.53477 7.53335 7.5501 209053_s_ WHSC1 6.73559 6.91166 8.75599 8.72304 205167_s_ CDC25C 5.68484 5.72264 7.5945 7.63836 203046_s_ TIMELESS 6.25243 6.30633 8.18796 8.19511 213334_x_ UCHL5IP 5.70106 5.62132 7.65354 7.48601 218103_at FTSJ3 7.767 7.76203 9.62203 9.71515 205436_s_ H2AFX 8.50529 8.64209 10.47275 10.4535 214086_s_ PARP2 6.11241 6.5055 8.34604 8.04437 209832_s_ CDT1 5.79348 5.47004 7.52161 7.50675 209891_at SPC25 4.71591 4.64974 6.56798 6.51905 201756_at RPA2 7.22688 7.33358 9.14669 9.12584 203564_at FANCG 6.7225 6.77269 8.72236 8.4743 212277_at MTMR4 6.20277 6.38423 8.28013 7.96531 221685_s_ CCDC99 6.57465 6.73426 8.56304 8.39762 201853_s_ CDC25B 7.89592 7.59482 9.46971 9.63494 203167_at TIMP2 6.7161 6.8315 8.54542 8.60535 221591_s_ FAM64A 6.80369 6.7144 8.61272 8.48579 200911_s_ TACC1 7.52479 7.43526 9.38146 9.12694 204441_s_ POLA2 6.34386 6.39485 8.19814 8.0829 204026_s_ ZWINT 7.58456 7.84155 9.51542 9.45177 213943_at TWIST1 4.24541 4.65333 6.20475 6.21684 214129_at PDE4DIP 4.8097 4.90303 6.59481 6.62263 201764_at TMEM106C 8.1822 8.14755 9.92736 9.90674 203358_s_ EZH2 4.45812 4.46874 6.50848 5.90716 204126_s_ CDC45L 7.00892 6.93316 8.75194 8.66322 219392_x_ PRR11 7.56482 7.69865 9.35731 9.31853 204409_s_ EIF1AY 3.61038 3.42106 5.3588 5.0795 203069_at SV2A 6.68737 6.68935 8.45092 8.32607 209507_at RPA3 7.65841 7.63917 9.39336 9.30247 205000_at DDX3Y 4.17118 4.0873 5.94663 5.70419 210664_s_ TFPI 4.41416 4.46419 6.2651 5.95531 215509_s_ WDR82 5.01396 4.90498 6.6443 6.58837 202037_s_ SFRP1 5.97527 5.69075 7.56057 7.40869 213587_s_ ATP6V0E2 5.78795 5.74425 7.47923 7.35512 204531_s_ BRCA1 6.10128 5.85988 7.75536 7.50144 211318_s_ RAE1 8.20273 8.31376 9.9003 9.86975 211761_s_ CACYBP 7.08032 7.33994 8.90522 8.71589 210517_s_ AKAP12 7.73959 7.72592 9.4709 9.19356 219588_s_ NCAPG2 6.50884 6.38684 8.13066 7.94132 201897_s_ CKS1B 8.86009 8.89627 10.49103 10.43173 218530_at FHOD1 6.34099 6.76743 8.12519 8.14935 201639_s_ CPSF1 6.75427 6.92065 8.35894 8.45958 218269_at RNASEN 7.29019 7.4614 8.89956 8.99148 218875_s_ FBXO5 4.03509 4.23389 5.87589 5.52735 212949_at NCAPH 6.5553 6.68467 8.16363 8.20599 218768_at NUP107 7.36944 7.52721 9.09001 8.92525 208668_x_ HMGN2 10.20297 10.33022 11.89914 11.73893 204825_at MELK 8.83756 8.92321 10.4723 10.39228 209350_s_ GPS2 6.87063 7.25733 8.58775 8.6043 206102_at GINS1 6.03476 6.40262 7.82083 7.6763 204709_s_ KIF23 4.30295 4.3334 5.97307 5.70134 213507_s_ KPNB1 10.01631 10.01413 11.46421 11.60015 209094_at DDAH1 7.77406 7.89588 9.35592 9.34045 200934_at DEK 8.28151 8.50978 10.17261 9.645 204640_s_ SPOP 7.59015 7.37021 9.05662 8.91991 208963_x_ FADS1 7.05987 6.83519 8.47902 8.42887 204649_at TROAP 6.89638 6.69971 8.3866 8.19998 204617_s_ ACD 7.21032 7.38563 8.77765 8.80411 205483_s_ ISG15 7.28508 7.36154 8.86503 8.76652 206066_s_ RAD51C 6.73323 7.01293 8.39847 8.31639 215116_s_ DNM1 6.16666 5.94946 7.67594 7.40813 208723_at USP11 7.45902 7.3813 8.98754 8.81566 221004_s_ ITM2C 7.94843 8.01688 9.47897 9.44696 202633_at TOPBP1 6.07343 6.16152 7.75805 7.42182 209431_s_ PATZ1 5.39236 5.26742 6.87831 6.72374 202385_s_ TCOF1 6.38476 6.2211 7.80405 7.73097 206441_s_ COMMD4 8.54166 8.4892 9.94818 9.99118 210095_s_ IGFBP3 6.66924 6.89701 8.19497 8.27532 201459_at RUVBL2 9.13279 9.14778 10.5175 10.64225 217841_s_ PPME1 7.65958 7.61602 9.10377 9.05008 204887_s_ PLK4 6.0181 5.95765 7.40167 7.4503 207842_s_ CASC3 7.34709 7.20345 8.82477 8.58491 208775_at XPO1 8.68747 8.83202 10.30195 10.06458 200661_at CTSA 8.33123 8.46065 9.7752 9.85625 205905_s_ MICA 7.27397 7.07611 8.66747 8.5221 213088_s_ DNAJC9 7.50983 7.62803 9.06689 8.90087 221675_s_ CHPT1 6.5944 6.61647 7.93779 8.07602 202246_s_ CDK4 8.59732 8.73547 10.05279 10.07674 209503_s_ PSMC5 8.80542 8.97148 10.23745 10.33103 204881_s_ UGCG 6.95418 7.09318 8.48525 8.34104 212789_at NCAPD3 6.3481 6.12317 7.58741 7.65889 213037_x_ STAU1 9.65537 9.84042 11.17866 11.06714 213520_at RECQL4 6.26899 6.08833 7.45164 7.64189 208749_x_ FLOT1 8.88759 8.99201 10.25395 10.35791 202144_s_ ADSL 8.56589 8.65292 9.97221 9.97809 217973_at DCXR 7.92477 7.88665 9.29456 9.24325 222047_s_ ARS2 8.20832 8.42587 9.65766 9.70018 221954_at C20orf111 6.03242 6.28619 7.50824 7.51133 201892_s_ IMPDH2 9.77075 9.94595 11.23416 11.17421 218493_at C16orf33 7.69325 7.89665 9.21795 9.05442 205909_at POLE2 7.08314 6.56557 8.16671 8.15681 201041_s_ DUSP1 8.90952 8.94531 10.31318 10.21128 203606_at NDUFS6 8.77524 9.18747 10.26778 10.32432 218339_at MRPL22 7.62581 7.74518 9.10811 8.88628 204295_at SURF1 8.12312 8.26376 9.52814 9.4811 205061_s_ EXOSC9 7.2963 7.31755 8.61259 8.59318 201476_s_ RRM1 7.3121 7.47167 8.66757 8.65262 200000_s_ PRPF8 8.99936 9.06107 10.23748 10.34818 213008_at FANCI 6.69239 6.70344 7.96206 7.95386 218391_at SNF8 7.8233 8.08736 9.2174 9.21072 205545_x_ DNAJC8 8.18024 8.39386 9.55569 9.50803 212832_s_ CKAP5 8.27142 8.25608 9.48656 9.52439 218517_at PHF17 6.51031 6.43833 7.70263 7.72754 218061_at MEA1 8.975 8.96977 10.23759 10.18592 216272_x_ SYDE1 6.71345 6.53874 7.85629 7.87354 218979_at RMI1 6.03787 5.97064 7.37822 7.08869 219105_x_ ORC6L 6.391 6.11397 7.45488 7.49696 204279_at PSMB9 6.17075 6.13241 7.3692 7.37811 200982_s_ ANXA6 6.94279 6.76602 8.06244 8.06388 202655_at ARMET 8.82469 8.90499 10.06688 10.06378 212801_at CIT 7.40308 7.10191 8.50736 8.3803 218741_at CENPM 6.52789 6.36336 7.53521 7.71466 213398_s_ C14orf124 7.24282 7.51055 8.51797 8.58221 209846_s_ BTN3A2 5.20753 5.4574 6.51928 6.47955 201636_at FXR1 6.18116 6.5045 7.50551 7.50447 213009_s_ TRIM37 7.75497 7.88757 8.98269 8.97863 200680_x_ HMGB1 10.22899 10.27972 11.43271 11.39429 203113_s_ EEF1D 10.1812 10.33583 11.48576 11.3442 212430_at RBM38 6.07755 6.22912 7.2105 7.409 203964_at NMI 5.03768 5.21278 6.3716 6.18295 214431_at GMPS 8.04963 8.12609 9.27077 9.19574 202332_at CSNK1E 6.21539 6.48084 7.53288 7.44939 202474_s_ HCFC1 8.17068 8.18835 9.35596 9.28319 212836_at POLD3 6.55864 6.54309 7.78162 7.58346 208773_s_ ANKHD1 7.13159 7.26152 8.35962 8.292 208445_s_ BAZ1B 7.18747 7.07593 8.33011 8.18256 204432_at SOX12 4.57059 4.38727 5.58433 5.61749 213346_at C13orf27 6.43989 6.48917 7.56454 7.6037 201865_x_ NR3C1 7.96121 7.86638 9.06602 9.00059 221488_s_ CUTA 9.65495 9.84985 10.85628 10.88738 218189_s_ NANS 7.15364 7.34906 8.49747 8.24253 203696_s_ RFC2 7.40046 7.40298 8.54481 8.46991 202395_at NSF 7.53514 7.71168 8.76544 8.6896 203252_at CDK2AP2 7.05783 7.22984 8.31365 8.17733 205519_at WDR76 4.79532 4.80737 5.82208 5.97864 201587_s_ IRAK1 9.48795 9.47362 10.538 10.61839 201267_s_ PSMC3 8.64358 8.73675 9.80753 9.75198 202309_at MTHFD1 7.59253 7.66269 8.83883 8.58754 218883_s_ MLF1IP 6.81786 7.00174 8.04221 7.9412 218080_x_ FAF1 8.01265 8.03228 9.14302 9.06318 202078_at COPS3 7.83154 7.81811 8.98384 8.8238 201315_x_ IFITM2 9.66285 9.81908 10.78965 10.84466 57532_at DVL2 6.9352 6.98734 8.08473 7.98872 212263_at QKI 6.49879 6.74745 7.84497 7.52456 218903_s_ OBFC2B 6.01811 5.9466 7.24029 6.84294 208819_at RAB8A 8.1008 8.35777 9.21578 9.35432 208511_at PTTG3 5.27871 5.20643 6.38 6.20134 210820_x_ COQ7 6.61677 6.55374 7.54285 7.71133 200041_s_ BAT1 10.02924 10.08897 11.10179 11.09364 209482_at POP7 7.64806 7.79296 8.74669 8.72123 206918_s_ CPNE1 8.2844 8.31863 9.27127 9.35056 202068_s_ LDLR 10.07549 10.20358 9.19332 9.08007 204334_at KLF7 8.33343 8.48483 7.3372 7.43322 202744_at SLC20A2 6.42374 6.69066 5.57358 5.4779 219099_at C12orf5 7.90619 7.94773 6.91506 6.87151 202711_at EFNB1 7.27199 7.16664 6.1938 6.17439 217165_x_ MT1F 11.38592 11.46529 10.45992 10.3207 218498_s_ ERO1L 7.52071 7.51868 6.46294 6.47866 219241_x_ SSH3 8.43883 8.43447 7.48983 7.28541 209806_at HIST1H2BK 7.66077 7.91071 6.76224 6.67747 208683_at CAPN2 10.87553 11.06573 9.94272 9.85726 201005_at CD9 10.71119 10.77832 9.74059 9.57532 217728_at S100A6 12.32856 12.28023 11.12267 11.26332 208156_x_ EPPK1 7.3044 6.96925 5.97106 6.0719 201594_s_ PPP4R1 9.53048 9.64094 8.47992 8.43043 202117_at ARHGAP1 9.42558 9.60419 8.30874 8.44238 201207_at TNFAIP1 9.45684 9.61595 8.40462 8.38583 214040_s_ GSN 7.02716 7.07145 5.75333 5.98407 201061_s_ STOM 10.17779 10.35982 9.15657 9.01177 212799_at STX6 8.55069 8.84678 7.51418 7.5099 209173_at AGR2 6.74611 6.94487 5.61175 5.65983 217930_s_ TOLLIP 7.97929 8.12513 6.83871 6.79392 221898_at PDPN 5.64325 5.83566 4.47483 4.50569 211043_s_ CLTB 10.31442 10.28937 9.05954 9.02818 201243_s_ ATP1B1 9.56782 9.53052 8.31364 8.24869 201149_s_ TIMP3 7.11473 7.00261 5.73389 5.83664 211749_s_ VAMP3 9.76252 9.7862 8.62545 8.34696 203417_at MFAP2 8.26345 8.42135 7.19655 6.90943 204388_s_ MAOA 6.28627 6.25085 5.11759 4.82416 202828_s_ MMP14 8.03345 8.38887 6.84296 6.96866 207121_s_ MAPK6 10.27022 10.277 8.93812 8.96829 212463_at CD59 8.81114 8.85591 7.55899 7.46124 209348_s_ MAF 5.54947 4.5671 3.69895 3.76542 212169_at FKBP9 9.83342 9.84638 8.54897 8.46743 210241_s_ TP53AP1 6.61242 6.69494 5.24221 5.37962 217118_s_ C22orf9 9.36429 9.49244 8.09437 8.05551 218368_s_ TNFRSF12A 10.10452 10.24749 8.83174 8.80586 218499_at RP6-213H19.1 7.19725 7.59778 6.13362 5.93785 200872_at S100A10 12.27905 12.17041 10.86222 10.84631 202729_s_ LTBP1 7.73556 7.72154 6.23735 6.4759 211559_s_ CCNG2 8.45938 8.54896 7.11336 7.14002 201723_s_ GALNT1 9.03864 8.84976 7.58513 7.53649 215411_s_ TRAF3IP2 9.5009 9.59966 8.19949 8.11689 221728_x_ XIST 6.75299 6.83111 5.32591 5.44963 212008_at UBXD2 8.06804 8.46403 6.8761 6.84562 219257_s_ SPHK1 9.10842 9.03568 7.6676 7.66559 213446_s_ IQGAP1 7.35369 7.52534 5.94697 6.11041 221477_s_ MGC5618 7.51164 7.65035 6.19233 6.14119 211864_s_ FER1L3 8.55862 8.88724 7.36788 7.21829 214274_s_ ACAA1 7.02984 7.24114 5.74193 5.66866 210513_s_ VEGFA 8.19655 8.55456 6.92455 6.94267 200798_x_ MCL1 9.09149 9.24355 7.83869 7.58716 221730_at COL5A2 6.1425 6.09215 4.73255 4.57251 212418_at ELF1 7.38108 7.54952 6.07186 5.91238 219496_at ANKRD57 7.35196 7.29631 5.83097 5.85914 203430_at HEBP2 9.47209 9.54437 8.084 7.97062 202887_s_ DDIT4 10.99994 11.06874 9.58956 9.47608 201108_s_ THBS1 9.63649 9.58819 7.9642 8.24797 41660_at CELSR1 6.60049 6.83046 5.18032 5.22664 204679_at KCNK1 7.28704 7.659 5.9568 5.96288 219058_x_ TINAGL1 8.96804 8.89513 7.39427 7.4389 219024_at PLEKHA1 7.46325 7.36875 5.70241 6.09145 201259_s_ SYPL1 10.22225 10.28392 8.74433 8.71963 212593_s_ PDCD4 8.94966 9.05311 7.61345 7.34683 39249_at AQP3 8.80423 8.80323 7.26637 7.29661 205847_at PRSS22 7.49097 7.69512 6.12699 6.01115 217732_s_ ITM2B 11.30556 11.18245 9.76602 9.67213 202363_at SPOCK1 7.6612 7.62751 5.97203 6.26291 202207_at ARL4C 6.9702 6.90874 5.39331 5.42074 204136_at COL7A1 8.26966 8.68299 6.93319 6.94733 213279_at DHRS1 9.03958 9.12875 7.52503 7.56686 218902_at NOTCH1 7.49226 7.3675 6.07215 5.70509 217999_s_ PHLDA1 7.00438 7.08174 5.36195 5.63948 206582_s_ GPR56 7.70367 7.73127 6.07688 6.20431 202546_at VAMP8 9.95557 9.88576 8.39131 8.28957 205376_at INPP4B 6.79275 6.83648 5.15611 5.24218 210582_s_ LIMK2 8.60707 8.84974 7.04655 7.17865 203066_at GALNAC4S-6ST 7.69548 7.88977 6.17673 6.17545 207020_at HSF2BP 7.53843 7.54046 5.9105 5.91656 213757_at EIF5A 9.544 9.5833 7.97977 7.88668 202565_s_ SVIL 7.23568 7.13679 5.65858 5.43284 201301_s_ ANXA4 8.75913 8.85501 7.24328 7.08852 221666_s_ PYCARD 8.6451 8.94787 7.18435 7.12108 203476_at TPBG 10.37138 10.56616 8.839 8.80488 217730_at TMBIM1 9.85478 9.91437 8.2589 8.20667 219995_s_ ZNF750 5.50108 5.48853 3.88466 3.78815 201940_at CPD 8.45883 8.75367 6.97887 6.91658 217787_s_ GALNT2 7.05365 7.62406 5.81255 5.52623 202388_at RGS2 7.49805 7.49083 5.83273 5.81376 204201_s_ PTPN13 5.99167 5.39998 3.99381 4.03736 218834_s_ TMEM132A 8.40086 8.48671 6.76414 6.76098 209189_at FOS 8.96802 8.82502 7.27764 7.15046 210830_s_ PON2 8.62647 8.8876 7.11867 7.02618 213924_at MPPE1 7.87127 7.85724 6.13157 6.22649 208370_s_ RCAN1 7.97385 8.21458 6.33906 6.4685 210916_s_ CD44 8.98935 9.51169 7.50697 7.60411 214875_x_ APLP2 10.14165 10.27866 8.50196 8.52057 213274_s_ CTSB 9.46145 9.66953 7.83233 7.88354 209946_at VEGFC 7.30338 7.08529 5.50663 5.46624 214247_s_ DKK3 9.32366 9.41263 7.76842 7.54973 221269_s_ SH3BGRL3 10.65769 10.67929 8.97641 8.91897 211676_s_ IFNGR1 8.95223 9.07712 7.3063 7.27861 208690_s_ PDLIM1 11.22237 11.16397 9.46156 9.47857 218280_x_ HIST2H2AA3 8.25543 8.28167 6.50706 6.54114 210020_x_ CALML3 7.21787 7.45938 5.44551 5.73221 215388_s_ CFHR1 6.32053 6.03395 4.31222 4.52977 210663_s_ KYNU 7.86435 7.72535 5.93413 6.1193 201487_at CTSC 9.88946 9.999 8.19433 8.13898 209387_s_ TM4SF1 7.27453 7.21645 5.37985 5.54476 204466_s_ SNCA 8.35062 8.41684 6.60941 6.58191 200641_s_ YWHAZ 10.7814 10.83742 9.06125 8.97933 218261_at AP1M2 8.18843 8.5556 6.49265 6.66932 212702_s_ BICD2 8.62096 8.8411 7.02569 6.84736 204204_at SLC31A2 7.57488 7.7239 5.81579 5.88323 202720_at TES 7.89198 7.98508 6.08995 6.18558 203243_s_ PDLIM5 8.43422 8.31284 6.71603 6.4249 205185_at SPINK5 8.01993 8.1956 6.26081 6.33799 209873_s_ PKP3 9.13396 9.19598 7.14549 7.56338 200730_s_ PTP4A1 8.95601 8.86476 7.20081 6.96879 202693_s_ STK17A 8.41325 8.52798 6.74966 6.52069 209727_at GM2A 8.93848 8.88498 6.93289 7.21652 206094_x_ UGT1A6 8.17901 8.53534 6.4598 6.56456 215707_s_ PRNP 9.54418 9.58898 7.50679 7.84272 217892_s_ LIMA1 10.42361 10.44549 8.57977 8.48882 218810_at ZC3H12A 7.91984 7.96221 6.02298 6.04879 204532_x_ UGT1A9 8.37081 8.43279 6.3761 6.6039 206156_at GJB5 7.4051 7.39336 5.45072 5.52124 218960_at TMPRSS4 7.79743 7.78009 5.7104 6.03964 1007_s_at DDR1 10.52212 10.53219 8.51415 8.69208 218854_at DSE 8.72243 8.87916 7.00551 6.72578 213110_s_ COL4A5 6.60415 6.88299 4.91839 4.69082 201425_at ALDH2 9.39418 9.55597 7.5103 7.53414 204751_x_ DSC2 7.26394 7.07877 5.20032 5.23055 211272_s_ DGKA 7.05728 7.34505 5.20534 5.26741 200637_s_ PTPRF 9.00974 9.18308 7.23526 7.02302 205490_x_ GJB3 9.19228 9.50289 7.37433 7.3469 40016_g_aMAST4 8.25249 8.31333 6.11164 6.46721 218644_at PLEK2 9.03013 9.19588 7.10887 7.12628 200965_s_ ABLIM1 8.88506 8.75615 6.73802 6.90693 38037_at HBEGF 7.54665 7.80763 5.68219 5.64462 203287_at LAD1 9.03127 8.97559 6.83414 7.13255 203038_at PTPRK 10.3725 10.58555 8.52163 8.38722 208153_s_ FAT2 7.06599 7.37304 5.00943 5.3711 209114_at TSPAN1 8.94769 9.10009 6.87496 7.11377 213992_at COL4A6 7.48177 7.68273 5.51779 5.58399 209550_at NDN 7.78519 7.78186 5.768 5.72991 201599_at OAT 10.03528 10.00483 8.06508 7.89942 202351_at ITGAV 9.56596 9.67633 7.66776 7.45724 201739_at SGK 8.68256 8.8189 6.61205 6.71211 203423_at RBP1 8.1072 8.32553 6.06815 6.18617 206714_at ALOX15B 8.2033 8.25208 6.00849 6.266 208540_x_ S100A11P 10.31736 10.33016 8.23159 8.22871 205767_at EREG 6.32995 6.62931 4.46051 4.24225 204858_s_ ECGF1 9.12686 9.503 7.17134 7.18268 203315_at NCK2 8.62697 8.73029 6.77277 6.30794 200906_s_ PALLD 7.80125 8.07243 5.68683 5.90331 203381_s_ APOE 7.57551 7.68248 5.45813 5.48454 212543_at AIM1 9.45349 9.57115 7.38777 7.30588 201983_s_ EGFR 9.04246 9.09143 6.88055 6.91421 212063_at PTGES3 9.99947 10.29148 8.07193 7.87838 209792_s_ KLK10 7.57514 7.50915 5.31401 5.42506 208596_s_ UGT1A3 8.3377 7.95481 5.9516 5.98415 211834_s_ TP63 7.53081 7.60194 5.29668 5.46907 202643_s_ TNFAIP3 8.22072 8.35434 6.10892 6.09373 203238_s_ NOTCH3 7.80147 7.87091 5.7381 5.5534 212812_at SERINC5 8.0518 8.10438 5.97788 5.79462 201616_s_ CALD1 7.90412 8.33689 5.96584 5.88749 203233_at IL4R 8.93273 8.906 6.76084 6.68416 206032_at DSC3 9.07918 9.03624 6.83917 6.88219 202525_at PRSS8 7.84759 8.0367 5.65415 5.82152 203797_at VSNL1 8.33198 8.31448 6.01374 6.22241 218035_s_ FLJ20273 7.39111 7.58305 5.25995 5.30334 207126_x_ UGT1A1 8.60858 9.07982 6.47462 6.80001 217995_at SQRDL 10.35664 10.50301 8.16747 8.27096 203042_at LAMP2 7.2489 7.30879 5.20477 4.92473 201312_s_ SH3BGRL 8.02594 8.08208 6.06828 5.58975 205349_at GNA15 8.51543 8.91352 6.49486 6.46021 213848_at 8.69995 8.8867 6.74486 6.3428 202421_at IGSF3 8.56068 8.44427 6.51711 5.97559 210809_s_ POSTN 8.02989 8.20335 5.75154 5.93004 203788_s_ SEMA3C 7.15948 7.34857 4.96429 4.98208 201579_at FAT 9.55315 9.45049 7.1761 7.2384 204542_at ST6GALNAC2 8.89761 8.98395 6.66053 6.60923 200824_at GSTP1 11.40546 11.6144 9.16827 9.21505 208893_s_ DUSP6 8.73575 8.92937 6.33735 6.68048 204682_at LTBP2 8.27033 8.35828 6.02031 5.96039 214290_s_ HIST2H2AA4 8.96222 9.16485 6.79008 6.6724 208025_s_ HMGA2 7.72842 7.68942 5.45342 5.26747 204379_s_ FGFR3 8.30915 8.59458 6.47925 5.72055 201631_s_ IER3 11.10462 11.23385 8.74385 8.88803 203695_s_ DFNA5 8.86994 8.9872 6.69011 6.45526 204620_s_ VCAN 8.07759 7.92636 5.56957 5.67327 221664_s_ F11R 8.96593 9.03579 6.71159 6.50337 202826_at SPINT1 8.94545 9.22801 6.64736 6.70703 214701_s_ FN1 8.49349 8.70248 6.07001 6.28183 201506_at TGFBI 11.31885 11.30271 8.92331 8.84327 200660_at S100A11 11.75844 11.61723 9.32454 9.18593 212268_at SERPINB1 9.49148 9.7695 7.34841 7.03669 200632_s_ NDRG1 9.7177 9.70055 7.34911 7.15315 201201_at CSTB 12.00437 12.0888 9.63114 9.52387 219267_at GLTP 8.84843 8.78355 6.32053 6.31834 212192_at KCTD12 7.93651 7.9343 5.65669 5.17355 219648_at MREG 7.62319 7.82164 5.21706 5.135 206191_at ENTPD3 8.26991 8.34397 5.66926 5.80649 205321_at EIF2S3 8.91998 9.01732 6.42102 6.37513 212365_at MYO1B 10.35005 10.6002 8.08372 7.72223 33322_i_at SFN 13.32907 13.24127 10.73533 10.68948 212992_at AHNAK2 9.05874 9.10573 6.64086 6.37731 217202_s_ GLUL 9.55396 9.71028 6.95644 7.14358 201656_at ITGA6 8.20208 8.28732 5.61415 5.70832 219010_at C1orf106 9.15561 9.37019 6.69908 6.60197 214953_s_ APP 10.04714 10.10453 7.55761 7.3648 207517_at LAMC2 6.72884 7.34561 4.32973 4.45638 201841_s_ HSPB1 12.41039 12.4313 9.74363 9.7824 201287_s_ SDC1 11.28342 11.17486 8.62603 8.47416 218182_s_ CLDN1 8.08677 7.99327 5.38232 5.30195 216594_x_ AKR1C1 9.7119 9.61106 6.90487 7.00213 202597_at IRF6 10.37123 10.41907 7.66659 7.68423 219121_s_ RBM35A 8.59727 8.6428 5.93383 5.81723 208965_s_ PYHIN1 7.69311 7.99956 4.99263 5.17509 209211_at KLF5 6.82601 6.12087 3.68081 3.72112 214599_at IVL 7.85657 8.02725 5.17294 5.13645 219305_x_ FBXO2 8.75547 9.16278 6.20852 6.08187 208651_x_ CD24 10.9269 11.12781 8.33317 8.07661 206166_s_ CLCA2 8.21127 8.47326 5.4959 5.53167 208084_at ITGB6 7.89788 7.95763 5.10556 5.07885 201416_at SOX4 8.96789 9.24337 6.17233 6.27054 204359_at FLRT2 8.36163 8.23472 5.49381 5.32974 219412_at RAB38 8.86988 8.8515 5.79845 6.09915 211002_s_ TRIM29 9.06322 9.14959 6.17598 6.144 200951_s_ CCND2 7.67571 7.74286 4.68124 4.77163 216243_s_ IL1RN 9.77741 9.64121 6.67258 6.72704 202790_at CLDN7 9.4599 9.70761 6.37562 6.75887 219181_at LIPG 7.49197 7.58603 4.4442 4.5825 203037_s_ MTSS1 8.64522 9.12387 5.47575 6.22846 204948_s_ FST 10.44538 10.40893 7.36699 7.41162 206008_at TGM1 8.64918 8.74362 5.59551 5.69404 208712_at CCND1 9.07562 9.26133 6.0789 6.10356 202458_at PRSS23 10.34993 10.40918 7.371 7.17241 60474_at C20orf42 7.50793 7.49782 4.35256 4.34188 205479_s_ PLAU 10.18996 10.31254 7.0192 7.14833 204952_at LYPD3 9.97723 10.24523 6.74412 7.10748 202283_at SERPINF1 8.22651 8.34507 5.12996 5.03152 204470_at CXCL1 8.21852 8.34752 4.96402 5.17028 216905_s_ ST14 7.56189 7.89393 4.90941 4.05524 203180_at ALDH1A3 11.75899 11.5839 8.47615 8.3695 203397_s_ GALNT3 7.33822 7.70328 4.25604 4.25247 202345_s_ FABP5 10.9483 10.81681 7.68736 7.5386 209373_at MALL 9.53631 9.5061 6.12691 6.31687 208539_x_ SPRR2D 9.55707 9.67827 6.20822 6.39205 202575_at CRABP2 10.44237 10.73045 7.18683 7.34716 221854_at PKP1 9.21885 9.25114 5.99254 5.83829 204989_s_ ITGB4 9.76353 9.87216 6.51409 6.40159 201130_s_ CDH1 8.15198 8.46318 4.92218 4.91637 210592_s_ SAT1 11.84253 11.76742 8.5511 8.25781 205680_at MMP10 7.41776 7.73619 4.065 4.24479 219936_s_ GPR87 8.9571 8.89028 5.23652 5.7404 203562_at FEZ1 9.7312 9.92946 6.31527 6.47421 211657_at CEACAM6 9.19901 8.83284 5.47516 5.67995 204508_s_ CA12 8.55696 8.62346 5.21509 5.06817 206421_s_ SERPINB7 8.6153 8.79788 5.26862 5.21903 203074_at ANXA8L2 10.70114 10.77885 7.04717 7.37013 201012_at ANXA1 12.40624 12.36938 8.88871 8.78639 203780_at MPZL2 7.46193 7.42115 3.85276 3.88768 202859_x_ IL8 8.38062 8.49763 4.96549 4.74486 218856_at TNFRSF21 10.86193 10.82272 7.16321 7.34354 213285_at TMEM30B 8.02555 8.12819 4.5384 4.42269 203939_at NT5E 8.80114 8.88339 5.17204 5.30986 204019_s_ SH3YL1 8.70056 8.93472 5.2124 5.10219 201170_s_ BHLHB2 10.09624 10.09439 6.50933 6.3576 205595_at DSG3 9.78572 9.92713 6.32699 6.05318 209098_s_ JAG1 8.56168 8.45304 4.78172 4.76832 205476_at CCL20 8.19861 8.48425 4.54823 4.65815 209699_x_ AKR1C2 10.06902 10.32993 6.53571 6.26562 216918_s_ DST 11.20387 10.7495 7.13795 7.20604 204734_at KRT15 8.09479 8.21093 4.35189 4.3103 213139_at SNAI2 9.4724 9.28903 5.64908 5.46069 201015_s_ JUP 10.53121 10.42395 6.43685 6.73728 202687_s_ TNFSF10 7.9601 8.07847 4.05853 4.13702 39402_at IL1B 10.62089 10.72956 6.59263 6.87269 213240_s_ KRT4 9.77382 10.09562 5.69789 5.95714 218186_at RAB25 9.56793 9.69699 5.37455 5.61711 204636_at COL17A1 9.38647 9.42704 5.33523 5.19298 201667_at GJA1 9.56123 9.46195 5.39411 5.33277 209160_at AKR1C3 8.78783 9.01807 4.72815 4.71497 217744_s_ PERP 10.71432 10.43556 6.42112 6.30035 219554_at RHCG 9.92159 9.96334 5.5594 5.88244 206561_s_ AKR1B10 9.55308 9.72777 5.32588 5.49171 205016_at TGFA 9.10545 9.18687 5.01199 4.79508 212236_x_ KRT17 13.49034 13.48668 9.23366 9.19637 214370_at S100A8 7.95124 8.42903 3.91911 3.82171 202489_s_ FXYD3 11.62445 11.73373 7.37795 7.23905 204363_at F3 11.20539 11.02905 6.90294 6.5797 203726_s_ LAMA3 10.60258 10.8288 6.20514 6.43943 214580_x_ KRT6A 11.43607 11.16162 6.80655 6.98672 212531_at LCN2 10.8559 11.09059 6.49755 6.58102 200606_at DSP 10.97528 10.99492 6.62727 6.43999 205916_at S100A7 8.83453 9.23464 4.54707 4.55943 202286_s_ TACSTD2 12.25406 12.07294 7.70425 7.56483 222108_at AMIGO2 9.70075 9.71069 5.1539 5.19628 210413_x_ SERPINB4 10.07135 10.30826 5.5889 5.64154 206300_s_ PTHLH 8.76397 9.00389 4.21831 4.28285 201645_at TNC 10.3286 10.28847 5.64666 5.69879 212977_at CXCR7 8.68888 8.79309 4.08477 4.0264 218677_at S100A14 11.33858 11.3911 6.73552 6.56105 217272_s_ SERPINB13 9.57505 9.65488 4.64306 4.89551 209270_at LAMB3 11.09843 11.13291 6.4779 6.02436 209126_x_ KRT6B 12.84388 12.82646 7.86869 8.0098 41469_at PI3 10.05314 10.02483 5.07967 5.13292 203256_at CDH3 11.62249 11.48916 6.56937 6.50888 209720_s_ SERPINB3 8.97456 9.04349 3.86815 4.09819 204855_at SERPINB5 10.34087 10.358 5.20643 5.3824 215867_x_ AP1G1 11.80905 11.87151 6.60115 6.70719 206400_at LGALS7 10.54658 10.59248 5.13335 5.53791 204614_at SERPINB2 10.10665 9.97078 4.59537 4.95155 205239_at AREG 10.08544 9.94328 4.71484 4.69294 204748_at PTGS2 9.65698 9.64523 4.19766 4.36897 210118_s_ IL1A 10.92263 10.85803 5.25917 5.55242 204351_at S100P 10.89102 11.10427 5.42998 5.57195 207935_s_ KRT13 9.88401 10.02254 4.41593 4.49325 213680_at KRT6C 11.44127 11.42715 5.88704 5.95149 203021_at SLPI 12.23221 12.29731 6.71336 6.66443 214549_x_ SPRR1A 12.09772 12.13877 6.43406 6.58431 209351_at KRT14 10.24256 10.38589 4.66951 4.71811 218990_s_ SPRR3 12.85147 12.63965 6.62446 6.84328 209800_at KRT16 10.58098 10.63486 4.54806 4.54422 201820_at KRT5 13.08548 12.91582 6.48625 6.38535 204971_at CSTA 11.97426 11.99024 5.35186 5.45117 203535_at S100A9 12.77321 12.88155 5.32226 5.92868 205064_at SPRR1B 12.11126 12.24735 4.79392 5.05904 Common genes found in list of 584 genes and in classifiers (cluster 6 of method A and method H) by Shedden et al
UNIQID Gene Symbol NHBE NHBE 1170-I 1170-I 204617_s_at ACD 7.21032 7.38563 8.77765 8.80411 206632_s_at APOBEC3B 4.72848 4.8887 7.12964 6.65284 219918_s_at ASPM 5.28862 5.34324 8.7263 8.57064 218782_s_at ATAD2 6.15161 5.96878 8.20406 8.07783 208079_s_at AURKA 6.29679 6.40948 9.91171 9.69634 209464_at AURKB 6.05333 6.00386 8.48122 8.24073 202095_s_at BIRC5 6.50116 6.41051 9.3914 9.46126 209642_at BUB1 5.66275 5.53486 8.88674 8.68235 203755_at BUB1B 6.14325 6.11144 9.03416 8.35966 213346_at C13orf27 6.43989 6.48917 7.56454 7.6037 218586_at C20orf20 5.7716 6.02001 7.94922 7.72369 203418_at CCNA2 6.58062 6.51267 8.8804 8.71035 214710_s_at CCNB1 6.94015 7.0748 10.16913 10.0888 202705_at CCNB2 7.03059 6.84297 10.06553 9.87355 210559_s_at CDC2 7.36906 7.40065 10.07504 10.15751 202870_s_at CDC20 6.69627 6.90821 10.41349 10.41872 205167_s_at CDC25C 5.68484 5.72264 7.5945 7.63836 204126_s_at CDC45L 7.00892 6.93316 8.75194 8.66322 203967_at CDC6 4.27673 4.15974 6.72476 6.61908 204510_at CDC7 5.28305 5.35059 7.32198 7.32436 221436_s_at CDCA3 6.14733 5.89605 8.4034 8.16958 209714_s_at CDKN3 5.89311 5.52785 9.64152 9.6531 209832_s_at CDT1 5.79348 5.47004 7.52161 7.50675 204962_s_at CENPA 6.19743 6.16452 8.70788 8.48882 205046_at CENPE 5.98696 6.29317 8.61613 8.58583 207828_s_at CENPF 6.28357 6.241 9.2663 9.25724 218741_at CENPM 6.52789 6.36336 7.53521 7.71466 219555_s_at CENPN 7.07354 7.05713 9.19914 8.87024 218542_at CEP55 6.1323 6.069 8.71267 8.19556 213088_s_at DNAJC9 7.50983 7.62803 9.06689 8.90087 200606_at DSP 10.97528 10.99492 6.62727 6.43999 218585_s_at DTL 5.58936 5.87779 8.48083 8.06151 218498_s_at ERO1L 7.52071 7.51868 6.46294 6.47866 203358_s_at EZH2 4.45812 4.46874 6.50848 5.90716 221591_s_at FAM64A 6.80369 6.7144 8.61272 8.48579 213008_at FANCI 6.69239 6.70344 7.96206 7.95386 218875_s_at FBXO5 4.03509 4.23389 5.87589 5.52735 202580_x_at FOXM1 6.48736 6.39606 9.19381 9.23036 206102_at GINS1 6.03476 6.40262 7.82083 7.6763 221521_s_at GINS2 5.80238 5.99782 8.16851 7.95321 205436_s_at H2AFX 8.50529 8.64209 10.47275 10.4535 207165_at HMMR 5.82082 5.9652 9.45646 9.27789 202503_s_at KIAA0101 8.34723 8.60063 10.46348 10.52473 212621_at KIAA0286 5.56223 5.85274 8.73945 8.57532 218755_at KIF20A 5.855 6.15602 9.78162 9.66608 204709_s_at KIF23 4.30295 4.3334 5.97307 5.70134 209408_at KIF2C 6.95833 6.96246 10.15248 9.97525 218355_at KIF4A 5.63595 6.00485 8.41328 8.53579 203276_at LMNB1 4.8238 4.88744 7.19534 6.95592 222037_at MCM4 5.73347 5.88537 8.19113 8.08262 201930_at MCM6 7.38982 7.44643 9.49836 9.33126 204825_at MELK 8.83756 8.92321 10.4723 10.39228 212022_s_at MKI67 6.51334 6.13525 8.86933 8.89086 218883_s_at MLF1IP 6.81786 7.00174 8.04221 7.9412 201710_at MYBL2 7.83597 8.01649 10.11557 10.15502 201774_s_at NCAPD2 5.96279 5.91167 8.95279 8.99555 212789_at NCAPD3 6.3481 6.12317 7.58741 7.65889 218663_at NCAPG 4.86487 4.88114 7.56264 7.34558 219588_s_at NCAPG2 6.50884 6.38684 8.13066 7.94132 212949_at NCAPH 6.5553 6.68467 8.16363 8.20599 218039_at NUSAP1 6.9429 7.09576 10.57265 10.41237 218903_s_at OBFC2B 6.01811 5.9466 7.24029 6.84294 201202_at PCNA 7.71881 7.82385 10.12291 9.7889 204887_s_at PLK4 6.0181 5.95765 7.40167 7.4503 205909_at POLE2 7.08314 6.56557 8.16671 8.15681 218009_s_at PRC1 6.31518 6.79019 9.51753 9.32408 201896_s_at PSRC1 6.11479 5.98385 8.04423 7.99867 203554_x_at PTTG1 9.06361 9.07869 11.61948 11.70968 208511_at PTTG3 5.27871 5.20643 6.38 6.20134 204146_at RAD51AP1 4.68035 4.84926 7.25473 6.81755 213520_at RECQL4 6.26899 6.08833 7.45164 7.64189 203696_s_at RFC2 7.40046 7.40298 8.54481 8.46991 204023_at RFC4 7.37809 7.32641 9.60522 9.58442 209773_s_at RRM2 8.56545 8.52748 11.32065 11.29004 201459_at RUVBL2 9.13279 9.14778 10.5175 10.64225 209891_at SPC25 4.71591 4.64974 6.56798 6.51905 218308_at TACC3 6.13579 6.48094 9.19284 8.98685 202338_at TK1 6.75829 7.01819 9.41703 9.51793 201291_s_at TOP2A 5.70258 5.41762 10.08766 9.49203 210052_s_at TPX2 7.38264 7.45135 9.81309 9.83591 204033_at TRIP13 6.93197 7.06294 9.93131 9.65661 204649_at TROAP 6.89638 6.69971 8.3866 8.19998 201714_at TUBG1 8.37128 8.47101 10.4332 10.3841 202589_at TYMS 8.66466 8.74335 11.2602 11.21259 202954_at UBE2C 7.55851 7.41853 10.86479 10.82996 202779_s_at UBE2S 8.62346 8.88 11.34133 11.21505 205519_at WDR76 4.79532 4.80737 5.82208 5.97864 215509_s_at WDR82 5.01396 4.90498 6.6443 6.58837 209053_s_at WHSC1 6.73559 6.91166 8.75599 8.72304 204026_s_at ZWINT 7.58456 7.84155 9.51542 9.45177 207039_at CDKN2A 5.82873 6.18435 8.77213 8.7197 210766_s_at CSE1L 8.26748 8.45593 10.53936 10.35427 200880_at DNAJA1 7.32016 7.26585 10.08778 9.81537 216237_s_at MCM5 5.88506 6.18848 8.7374 8.73185 202911_at MSH6 7.05715 7.28132 9.19224 9.22823 202107_s_at MCM2 6.78931 6.84267 9.84501 9.80419 204767_s_at FEN1 6.01217 6.31426 9.01338 9.01853 221677_s_at DONSON 5.23622 5.3902 7.89273 7.5612 203022_at RNASEH2A 7.31586 7.35768 9.77697 9.63139 201555_at MCM3 7.4364 7.56023 9.61138 9.57589 203976_s_at CHAF1A 5.72657 5.98714 7.95843 7.92244 203432_at TMPO 7.47211 7.52516 9.6479 9.47511 206550_s_at NUP155 6.17058 6.68104 8.54228 8.2412 218115_at ASF1B 7.26031 7.27682 9.21799 9.22614 203046_s_at TIMELESS 6.25243 6.30633 8.18796 8.19511 214086_s_at PARP2 6.11241 6.5055 8.34604 8.04437 201897_s_at CKS1B 8.86009 8.89627 10.49103 10.43173 200934_at DEK 8.28151 8.50978 10.17261 9.645 202633_at TOPBP1 6.07343 6.16152 7.75805 7.42182 212832_s_at CKAP5 8.27142 8.25608 9.48656 9.52439 214431_at GMPS 8.04963 8.12609 9.27077 9.19574 201476_s_at RRM1 7.3121 7.47167 8.66757 8.65262