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Propranolol-Mediated Attenuation of MMP-9 Excretion in Infants with Hemangiomas

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Propranolol-Mediated Attenuation of MMP-9 Excretion in Infants with Hemangiomas Supplementary Online Content Thaivalappil S, Bauman N, Saieg A, Movius E, Brown KJ, Preciado D. Propranolol-mediated attenuation of MMP-9 excretion in infants with hemangiomas. JAMA Otolaryngol Head Neck Surg. doi:10.1001/jamaoto.2013.4773 eTable. List of All of the Proteins Identified by Proteomics This supplementary material has been provided by the authors to give readers additional information about their work. © 2013 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 10/01/2021 eTable. List of All of the Proteins Identified by Proteomics Protein Name Prop 12 mo/4 Pred 12 mo/4 Δ Prop to Pred mo mo Myeloperoxidase OS=Homo sapiens GN=MPO 26.00 143.00 ‐117.00 Lactotransferrin OS=Homo sapiens GN=LTF 114.00 205.50 ‐91.50 Matrix metalloproteinase‐9 OS=Homo sapiens GN=MMP9 5.00 36.00 ‐31.00 Neutrophil elastase OS=Homo sapiens GN=ELANE 24.00 48.00 ‐24.00 Bleomycin hydrolase OS=Homo sapiens GN=BLMH 3.00 25.00 ‐22.00 CAP7_HUMAN Azurocidin OS=Homo sapiens GN=AZU1 PE=1 SV=3 4.00 26.00 ‐22.00 S10A8_HUMAN Protein S100‐A8 OS=Homo sapiens GN=S100A8 PE=1 14.67 30.50 ‐15.83 SV=1 IL1F9_HUMAN Interleukin‐1 family member 9 OS=Homo sapiens 1.00 15.00 ‐14.00 GN=IL1F9 PE=1 SV=1 MUC5B_HUMAN Mucin‐5B OS=Homo sapiens GN=MUC5B PE=1 SV=3 2.00 14.00 ‐12.00 MUC4_HUMAN Mucin‐4 OS=Homo sapiens GN=MUC4 PE=1 SV=3 1.00 12.00 ‐11.00 HRG_HUMAN Histidine‐rich glycoprotein OS=Homo sapiens GN=HRG 1.00 12.00 ‐11.00 PE=1 SV=1 TKT_HUMAN Transketolase OS=Homo sapiens GN=TKT PE=1 SV=3 17.00 28.00 ‐11.00 CATG_HUMAN Cathepsin G OS=Homo sapiens GN=CTSG PE=1 SV=2 4.00 14.00 ‐10.00 MUCB_HUMAN Ig mu heavy chain disease protein OS=Homo sapiens 2.00 11.00 ‐9.00 PE=1 SV=1 ANXA1_HUMAN Annexin A1 OS=Homo sapiens GN=ANXA1 PE=1 SV=2 22.00 31.00 ‐9.00 S10AC_HUMAN Protein S100‐A12 OS=Homo sapiens GN=S100A12 1.00 8.00 ‐7.00 PE=1 SV=2 TCO1_HUMAN Transcobalamin‐1 OS=Homo sapiens GN=TCN1 PE=1 1.00 8.00 ‐7.00 SV=2 PLSL_HUMAN Plastin‐2 OS=Homo sapiens GN=LCP1 PE=1 SV=6 11.00 18.00 ‐7.00 ITAM_HUMAN Integrin alpha‐M OS=Homo sapiens GN=ITGAM PE=1 2.00 8.00 ‐6.00 SV=2 MYH9_HUMAN Myosin‐9 OS=Homo sapiens GN=MYH9 PE=1 SV=4 5.00 11.00 ‐6.00 S100P_HUMAN Protein S100‐P OS=Homo sapiens GN=S100P PE=1 6.00 12.00 ‐6.00 © 2013 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 10/01/2021 SV=2 ANXA3_HUMAN Annexin A3 OS=Homo sapiens GN=ANXA3 PE=1 SV=3 8.00 14.00 ‐6.00 TALDO_HUMAN Transaldolase OS=Homo sapiens GN=TALDO1 PE=1 2.00 7.50 ‐5.50 SV=2 CEAM5_HUMAN Carcinoembryonic antigen‐related cell adhesion 8.00 13.00 ‐5.00 molecule 5 OS=Homo sapiens GN=CEACAM5 PE=1 SV=2 STOM_HUMAN Erythrocyte band 7 integral membrane protein 1.00 5.00 ‐4.00 OS=Homo sapiens GN=STOM PE=1 SV=3 CAMP_HUMAN Cathelicidin antimicrobial peptide OS=Homo sapiens 2.00 6.00 ‐4.00 GN=CAMP PE=1 SV=1 BASP1_HUMAN Brain acid soluble protein 1 OS=Homo sapiens 2.00 6.00 ‐4.00 GN=BASP1 PE=1 SV=2 IGHM_HUMAN Ig mu chain C region OS=Homo sapiens GN=IGHM PE=1 5.00 8.50 ‐3.50 SV=3 SPA12_HUMAN Serpin A12 OS=Homo sapiens GN=SERPINA12 PE=2 1.00 4.17 ‐3.17 SV=1 CPNS2_HUMAN Calpain small subunit 2 OS=Homo sapiens GN=CAPNS2 1.00 4.00 ‐3.00 PE=2 SV=2 PSA5_HUMAN Proteasome subunit alpha type‐5 OS=Homo sapiens 1.00 4.00 ‐3.00 GN=PSMA5 PE=1 SV=3 PGRP1_HUMAN Peptidoglycan recognition protein 1 OS=Homo sapiens 1.00 4.00 ‐3.00 GN=PGLYRP1 PE=1 SV=1 APOA1_HUMAN Apolipoprotein A‐I OS=Homo sapiens GN=APOA1 5.25 8.20 ‐2.95 PE=1 SV=1 SPB6_HUMAN Serpin B6 OS=Homo sapiens GN=SERPINB6 PE=1 SV=3 0.33 3.00 ‐2.67 DSC2_HUMAN Desmocollin‐2 OS=Homo sapiens GN=DSC2 PE=1 SV=1 0.33 2.50 ‐2.17 IQGA1_HUMAN Ras GTPase‐activating‐like protein IQGAP1 OS=Homo 1.00 3.00 ‐2.00 sapiens GN=IQGAP1 PE=1 SV=1 DMBT1_HUMAN Deleted in malignant brain tumors 1 protein 1.00 3.00 ‐2.00 OS=Homo sapiens GN=DMBT1 PE=1 SV=2 PSB4_HUMAN Proteasome subunit beta type‐4 OS=Homo sapiens 1.00 3.00 ‐2.00 GN=PSMB4 PE=1 SV=4 PSA2_HUMAN Proteasome subunit alpha type‐2 OS=Homo sapiens 1.00 3.00 ‐2.00 © 2013 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 10/01/2021 GN=PSMA2 PE=1 SV=2 SBSN_HUMAN Suprabasin OS=Homo sapiens GN=SBSN PE=2 SV=1 1.00 3.00 ‐2.00 SPB8_HUMAN Serpin B8 OS=Homo sapiens GN=SERPINB8 PE=1 SV=2 1.00 3.00 ‐2.00 SODM_HUMAN Superoxide dismutase [Mn], mitochondrial OS=Homo 1.00 3.00 ‐2.00 sapiens GN=SOD2 PE=1 SV=2 VASP_HUMAN Vasodilator‐stimulated phosphoprotein OS=Homo 1.00 3.00 ‐2.00 sapiens GN=VASP PE=1 SV=3 PAI2_HUMAN Plasminogen activator inhibitor 2 OS=Homo sapiens 1.00 3.00 ‐2.00 GN=SERPINB2 PE=1 SV=2 ITB2_HUMAN Integrin beta‐2 OS=Homo sapiens GN=ITGB2 PE=1 SV=2 1.00 3.00 ‐2.00 MDHM_HUMAN Malate dehydrogenase, mitochondrial OS=Homo 2.00 4.00 ‐2.00 sapiens GN=MDH2 PE=1 SV=3 CEAM1_HUMAN Carcinoembryonic antigen‐related cell adhesion 4.00 6.00 ‐2.00 molecule 1 OS=Homo sapiens GN=CEACAM1 PE=1 SV=2 VTNC_HUMAN Vitronectin OS=Homo sapiens GN=VTN PE=1 SV=1 0.75 2.67 ‐1.92 ANGT_HUMAN Angiotensinogen OS=Homo sapiens GN=AGT PE=1 SV=1 0.33 2.20 ‐1.87 PROM1_HUMAN Prominin‐1 OS=Homo sapiens GN=PROM1 PE=1 SV=1 0.14 2.00 ‐1.86 CLM9_HUMAN CMRF35‐like molecule 9 OS=Homo sapiens 0.17 2.00 ‐1.83 GN=CD300LG PE=1 SV=2 S10A7_HUMAN Protein S100‐A7 OS=Homo sapiens GN=S100A7 PE=1 1.18 3.00 ‐1.82 SV=4 CATH_HUMAN Cathepsin H OS=Homo sapiens GN=CTSH PE=1 SV=4 1.00 2.75 ‐1.75 CASPE_HUMAN Caspase‐14 OS=Homo sapiens GN=CASP14 PE=1 SV=2 1.22 2.85 ‐1.62 COMP_HUMAN Cartilage oligomeric matrix protein OS=Homo sapiens 0.43 2.00 ‐1.57 GN=COMP PE=1 SV=2 MOES_HUMAN Moesin OS=Homo sapiens GN=MSN PE=1 SV=3 1.50 3.00 ‐1.50 LCN1_HUMAN Lipocalin‐1 OS=Homo sapiens GN=LCN1 PE=1 SV=1 1.00 2.25 ‐1.25 GGCT_HUMAN Gamma‐glutamylcyclotransferase OS=Homo sapiens 1.00 2.21 ‐1.21 GN=GGCT PE=1 SV=1 CATA_HUMAN Catalase OS=Homo sapiens GN=CAT PE=1 SV=3 1.00 2.20 ‐1.20 IGHA1_HUMAN Ig alpha‐1 chain C region OS=Homo sapiens GN=IGHA1 1.48 2.57 ‐1.09 PE=1 SV=2 © 2013 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 10/01/2021 CEAM8_HUMAN Carcinoembryonic antigen‐related cell adhesion 1.14 2.20 ‐1.06 molecule 8 OS=Homo sapiens GN=CEACAM8 PE=1 SV=2 SH3L3_HUMAN SH3 domain‐binding glutamic acid‐rich‐like protein 3 1.17 2.20 ‐1.03 OS=Homo sapiens GN=SH3BGRL3 PE=1 SV=1 AFAM_HUMAN Afamin OS=Homo sapiens GN=AFM PE=1 SV=1 1.00 2.00 ‐1.00 GRP78_HUMAN 78 kDa glucose‐regulated protein OS=Homo sapiens 1.00 2.00 ‐1.00 GN=HSPA5 PE=1 SV=2 A2ML1_HUMAN Alpha‐2‐macroglobulin‐like protein 1 OS=Homo 1.00 2.00 ‐1.00 sapiens GN=A2ML1 PE=1 SV=3 SPB7_HUMAN Serpin B7 OS=Homo sapiens GN=SERPINB7 PE=2 SV=1 1.00 2.00 ‐1.00 RNAS7_HUMAN Ribonuclease 7 OS=Homo sapiens GN=RNASE7 PE=1 1.00 2.00 ‐1.00 SV=2 CAP1_HUMAN Adenylyl cyclase‐associated protein 1 OS=Homo sapiens 1.00 2.00 ‐1.00 GN=CAP1 PE=1 SV=5 PSA1_HUMAN Proteasome subunit alpha type‐1 OS=Homo sapiens 1.00 2.00 ‐1.00 GN=PSMA1 PE=1 SV=1 LV301_HUMAN Ig lambda chain V‐III region SH OS=Homo sapiens PE=1 1.00 2.00 ‐1.00 SV=1 GSTO1_HUMAN Glutathione S‐transferase omega‐1 OS=Homo sapiens 1.00 2.00 ‐1.00 GN=GSTO1 PE=1 SV=2 RAB7A_HUMAN Ras‐related protein Rab‐7a OS=Homo sapiens 1.00 2.00 ‐1.00 GN=RAB7A PE=1 SV=1 TAGL2_HUMAN Transgelin‐2 OS=Homo sapiens GN=TAGLN2 PE=1 SV=3 1.00 2.00 ‐1.00 BST1_HUMAN ADP‐ribosyl cyclase 2 OS=Homo sapiens GN=BST1 PE=1 1.00 2.00 ‐1.00 SV=2 PSA6_HUMAN Proteasome subunit alpha type‐6 OS=Homo sapiens 1.00 2.00 ‐1.00 GN=PSMA6 PE=1 SV=1 INO80_HUMAN Putative DNA helicase INO80 complex homolog 1 1.00 2.00 ‐1.00 OS=Homo sapiens GN=INO80 PE=1 SV=2 LYSC_HUMAN Lysozyme C OS=Homo sapiens GN=LYZ PE=1 SV=1 1.00 2.00 ‐1.00 PSB1_HUMAN Proteasome subunit beta type‐1 OS=Homo sapiens 1.00 2.00 ‐1.00 GN=PSMB1 PE=1 SV=2 PAPP1_HUMAN Pappalysin‐1 OS=Homo sapiens GN=PAPPA PE=1 SV=3 1.00 2.00 ‐1.00 © 2013 American Medical Association.
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