Supplementary Online Content

Thaivalappil S, Bauman N, Saieg A, Movius E, Brown KJ, Preciado D. Propranolol-mediated attenuation of MMP-9 excretion in infants with hemangiomas. JAMA Otolaryngol Head Neck Surg. doi:10.1001/jamaoto.2013.4773

eTable. List of All of the Proteins Identified by Proteomics

This supplementary material has been provided by the authors to give readers additional information about their work.

© 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 eTable. List of All of the Proteins Identified by Proteomics

Protein Name Prop 12 mo/4 Pred 12 mo/4 Δ Prop to Pred mo mo Myeloperoxidase OS=Homo sapiens GN=MPO 26.00 143.00 ‐117.00 Lactotransferrin OS=Homo sapiens GN=LTF 114.00 205.50 ‐91.50 Matrix metalloproteinase‐9 OS=Homo sapiens GN=MMP9 5.00 36.00 ‐31.00 Neutrophil elastase OS=Homo sapiens GN=ELANE 24.00 48.00 ‐24.00 Bleomycin hydrolase OS=Homo sapiens GN=BLMH 3.00 25.00 ‐22.00 CAP7_HUMAN Azurocidin OS=Homo sapiens GN=AZU1 PE=1 SV=3 4.00 26.00 ‐22.00 S10A8_HUMAN Protein S100‐A8 OS=Homo sapiens GN=S100A8 PE=1 14.67 30.50 ‐15.83 SV=1 IL1F9_HUMAN Interleukin‐1 family member 9 OS=Homo sapiens 1.00 15.00 ‐14.00 GN=IL1F9 PE=1 SV=1 MUC5B_HUMAN Mucin‐5B OS=Homo sapiens GN=MUC5B PE=1 SV=3 2.00 14.00 ‐12.00 MUC4_HUMAN Mucin‐4 OS=Homo sapiens GN=MUC4 PE=1 SV=3 1.00 12.00 ‐11.00 HRG_HUMAN Histidine‐rich glycoprotein OS=Homo sapiens GN=HRG 1.00 12.00 ‐11.00 PE=1 SV=1 TKT_HUMAN Transketolase OS=Homo sapiens GN=TKT PE=1 SV=3 17.00 28.00 ‐11.00 CATG_HUMAN Cathepsin G OS=Homo sapiens GN=CTSG PE=1 SV=2 4.00 14.00 ‐10.00 MUCB_HUMAN Ig mu heavy chain disease protein OS=Homo sapiens 2.00 11.00 ‐9.00 PE=1 SV=1 ANXA1_HUMAN Annexin A1 OS=Homo sapiens GN=ANXA1 PE=1 SV=2 22.00 31.00 ‐9.00 S10AC_HUMAN Protein S100‐A12 OS=Homo sapiens GN=S100A12 1.00 8.00 ‐7.00 PE=1 SV=2 TCO1_HUMAN Transcobalamin‐1 OS=Homo sapiens GN=TCN1 PE=1 1.00 8.00 ‐7.00 SV=2 PLSL_HUMAN Plastin‐2 OS=Homo sapiens GN=LCP1 PE=1 SV=6 11.00 18.00 ‐7.00 ITAM_HUMAN Integrin alpha‐M OS=Homo sapiens GN=ITGAM PE=1 2.00 8.00 ‐6.00 SV=2 MYH9_HUMAN Myosin‐9 OS=Homo sapiens GN=MYH9 PE=1 SV=4 5.00 11.00 ‐6.00 S100P_HUMAN Protein S100‐P OS=Homo sapiens GN=S100P PE=1 6.00 12.00 ‐6.00

© 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 SV=2 ANXA3_HUMAN Annexin A3 OS=Homo sapiens GN=ANXA3 PE=1 SV=3 8.00 14.00 ‐6.00 TALDO_HUMAN Transaldolase OS=Homo sapiens GN=TALDO1 PE=1 2.00 7.50 ‐5.50 SV=2 CEAM5_HUMAN Carcinoembryonic antigen‐related cell adhesion 8.00 13.00 ‐5.00 molecule 5 OS=Homo sapiens GN=CEACAM5 PE=1 SV=2 STOM_HUMAN Erythrocyte band 7 integral membrane protein 1.00 5.00 ‐4.00 OS=Homo sapiens GN=STOM PE=1 SV=3 CAMP_HUMAN Cathelicidin antimicrobial peptide OS=Homo sapiens 2.00 6.00 ‐4.00 GN=CAMP PE=1 SV=1 BASP1_HUMAN Brain acid soluble protein 1 OS=Homo sapiens 2.00 6.00 ‐4.00 GN=BASP1 PE=1 SV=2 IGHM_HUMAN Ig mu chain C region OS=Homo sapiens GN=IGHM PE=1 5.00 8.50 ‐3.50 SV=3 SPA12_HUMAN Serpin A12 OS=Homo sapiens GN=SERPINA12 PE=2 1.00 4.17 ‐3.17 SV=1 CPNS2_HUMAN Calpain small subunit 2 OS=Homo sapiens GN=CAPNS2 1.00 4.00 ‐3.00 PE=2 SV=2 PSA5_HUMAN Proteasome subunit alpha type‐5 OS=Homo sapiens 1.00 4.00 ‐3.00 GN=PSMA5 PE=1 SV=3 PGRP1_HUMAN Peptidoglycan recognition protein 1 OS=Homo sapiens 1.00 4.00 ‐3.00 GN=PGLYRP1 PE=1 SV=1 APOA1_HUMAN Apolipoprotein A‐I OS=Homo sapiens GN=APOA1 5.25 8.20 ‐2.95 PE=1 SV=1 SPB6_HUMAN Serpin B6 OS=Homo sapiens GN=SERPINB6 PE=1 SV=3 0.33 3.00 ‐2.67 DSC2_HUMAN Desmocollin‐2 OS=Homo sapiens GN=DSC2 PE=1 SV=1 0.33 2.50 ‐2.17 IQGA1_HUMAN Ras GTPase‐activating‐like protein IQGAP1 OS=Homo 1.00 3.00 ‐2.00 sapiens GN=IQGAP1 PE=1 SV=1 DMBT1_HUMAN Deleted in malignant brain tumors 1 protein 1.00 3.00 ‐2.00 OS=Homo sapiens GN=DMBT1 PE=1 SV=2 PSB4_HUMAN Proteasome subunit beta type‐4 OS=Homo sapiens 1.00 3.00 ‐2.00 GN=PSMB4 PE=1 SV=4 PSA2_HUMAN Proteasome subunit alpha type‐2 OS=Homo sapiens 1.00 3.00 ‐2.00 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 GN=PSMA2 PE=1 SV=2 SBSN_HUMAN Suprabasin OS=Homo sapiens GN=SBSN PE=2 SV=1 1.00 3.00 ‐2.00 SPB8_HUMAN Serpin B8 OS=Homo sapiens GN=SERPINB8 PE=1 SV=2 1.00 3.00 ‐2.00 SODM_HUMAN Superoxide dismutase [Mn], mitochondrial OS=Homo 1.00 3.00 ‐2.00 sapiens GN=SOD2 PE=1 SV=2 VASP_HUMAN Vasodilator‐stimulated phosphoprotein OS=Homo 1.00 3.00 ‐2.00 sapiens GN=VASP PE=1 SV=3 PAI2_HUMAN Plasminogen activator inhibitor 2 OS=Homo sapiens 1.00 3.00 ‐2.00 GN=SERPINB2 PE=1 SV=2 ITB2_HUMAN Integrin beta‐2 OS=Homo sapiens GN=ITGB2 PE=1 SV=2 1.00 3.00 ‐2.00 MDHM_HUMAN Malate dehydrogenase, mitochondrial OS=Homo 2.00 4.00 ‐2.00 sapiens GN=MDH2 PE=1 SV=3 CEAM1_HUMAN Carcinoembryonic antigen‐related cell adhesion 4.00 6.00 ‐2.00 molecule 1 OS=Homo sapiens GN=CEACAM1 PE=1 SV=2 VTNC_HUMAN Vitronectin OS=Homo sapiens GN=VTN PE=1 SV=1 0.75 2.67 ‐1.92 ANGT_HUMAN Angiotensinogen OS=Homo sapiens GN=AGT PE=1 SV=1 0.33 2.20 ‐1.87 PROM1_HUMAN Prominin‐1 OS=Homo sapiens GN=PROM1 PE=1 SV=1 0.14 2.00 ‐1.86 CLM9_HUMAN CMRF35‐like molecule 9 OS=Homo sapiens 0.17 2.00 ‐1.83 GN=CD300LG PE=1 SV=2 S10A7_HUMAN Protein S100‐A7 OS=Homo sapiens GN=S100A7 PE=1 1.18 3.00 ‐1.82 SV=4 CATH_HUMAN Cathepsin H OS=Homo sapiens GN=CTSH PE=1 SV=4 1.00 2.75 ‐1.75 CASPE_HUMAN Caspase‐14 OS=Homo sapiens GN=CASP14 PE=1 SV=2 1.22 2.85 ‐1.62 COMP_HUMAN Cartilage oligomeric matrix protein OS=Homo sapiens 0.43 2.00 ‐1.57 GN=COMP PE=1 SV=2 MOES_HUMAN Moesin OS=Homo sapiens GN=MSN PE=1 SV=3 1.50 3.00 ‐1.50 LCN1_HUMAN Lipocalin‐1 OS=Homo sapiens GN=LCN1 PE=1 SV=1 1.00 2.25 ‐1.25 GGCT_HUMAN Gamma‐glutamylcyclotransferase OS=Homo sapiens 1.00 2.21 ‐1.21 GN=GGCT PE=1 SV=1 CATA_HUMAN Catalase OS=Homo sapiens GN=CAT PE=1 SV=3 1.00 2.20 ‐1.20 IGHA1_HUMAN Ig alpha‐1 chain C region OS=Homo sapiens GN=IGHA1 1.48 2.57 ‐1.09 PE=1 SV=2

© 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 CEAM8_HUMAN Carcinoembryonic antigen‐related cell adhesion 1.14 2.20 ‐1.06 molecule 8 OS=Homo sapiens GN=CEACAM8 PE=1 SV=2 SH3L3_HUMAN SH3 domain‐binding glutamic acid‐rich‐like protein 3 1.17 2.20 ‐1.03 OS=Homo sapiens GN=SH3BGRL3 PE=1 SV=1 AFAM_HUMAN Afamin OS=Homo sapiens GN=AFM PE=1 SV=1 1.00 2.00 ‐1.00 GRP78_HUMAN 78 kDa glucose‐regulated protein OS=Homo sapiens 1.00 2.00 ‐1.00 GN=HSPA5 PE=1 SV=2 A2ML1_HUMAN Alpha‐2‐macroglobulin‐like protein 1 OS=Homo 1.00 2.00 ‐1.00 sapiens GN=A2ML1 PE=1 SV=3 SPB7_HUMAN Serpin B7 OS=Homo sapiens GN=SERPINB7 PE=2 SV=1 1.00 2.00 ‐1.00 RNAS7_HUMAN Ribonuclease 7 OS=Homo sapiens GN=RNASE7 PE=1 1.00 2.00 ‐1.00 SV=2 CAP1_HUMAN Adenylyl cyclase‐associated protein 1 OS=Homo sapiens 1.00 2.00 ‐1.00 GN=CAP1 PE=1 SV=5 PSA1_HUMAN Proteasome subunit alpha type‐1 OS=Homo sapiens 1.00 2.00 ‐1.00 GN=PSMA1 PE=1 SV=1 LV301_HUMAN Ig lambda chain V‐III region SH OS=Homo sapiens PE=1 1.00 2.00 ‐1.00 SV=1 GSTO1_HUMAN Glutathione S‐transferase omega‐1 OS=Homo sapiens 1.00 2.00 ‐1.00 GN=GSTO1 PE=1 SV=2 RAB7A_HUMAN Ras‐related protein Rab‐7a OS=Homo sapiens 1.00 2.00 ‐1.00 GN=RAB7A PE=1 SV=1 TAGL2_HUMAN Transgelin‐2 OS=Homo sapiens GN=TAGLN2 PE=1 SV=3 1.00 2.00 ‐1.00 BST1_HUMAN ADP‐ribosyl cyclase 2 OS=Homo sapiens GN=BST1 PE=1 1.00 2.00 ‐1.00 SV=2 PSA6_HUMAN Proteasome subunit alpha type‐6 OS=Homo sapiens 1.00 2.00 ‐1.00 GN=PSMA6 PE=1 SV=1 INO80_HUMAN Putative DNA helicase INO80 complex homolog 1 1.00 2.00 ‐1.00 OS=Homo sapiens GN=INO80 PE=1 SV=2 LYSC_HUMAN Lysozyme C OS=Homo sapiens GN=LYZ PE=1 SV=1 1.00 2.00 ‐1.00 PSB1_HUMAN Proteasome subunit beta type‐1 OS=Homo sapiens 1.00 2.00 ‐1.00 GN=PSMB1 PE=1 SV=2 PAPP1_HUMAN Pappalysin‐1 OS=Homo sapiens GN=PAPPA PE=1 SV=3 1.00 2.00 ‐1.00 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 HAUS8_HUMAN HAUS augmin‐like complex subunit 8 OS=Homo 1.00 2.00 ‐1.00 sapiens GN=HAUS8 PE=1 SV=3 APOH_HUMAN Beta‐2‐glycoprotein 1 OS=Homo sapiens GN=APOH 1.00 2.00 ‐1.00 PE=1 SV=3 ZAP70_HUMAN Tyrosine‐protein kinase ZAP‐70 OS=Homo sapiens 1.00 2.00 ‐1.00 GN=ZAP70 PE=1 SV=1 TMC3_HUMAN Transmembrane channel‐like protein 3 OS=Homo 1.00 2.00 ‐1.00 sapiens GN=TMC3 PE=1 SV=2 AHNK_HUMAN Neuroblast differentiation‐associated protein AHNAK 1.00 2.00 ‐1.00 OS=Homo sapiens GN=AHNAK PE=1 SV=2 RSCA1_HUMAN Regulatory solute carrier protein family 1 member 1 1.00 2.00 ‐1.00 OS=Homo sapiens GN=RSC1A1 PE=2 SV=1 S1A7A_HUMAN Protein S100‐A7A OS=Homo sapiens GN=S100A7A 1.75 2.75 ‐1.00 PE=2 SV=3 KV105_HUMAN Ig kappa chain V‐I region DEE OS=Homo sapiens PE=1 2.00 3.00 ‐1.00 SV=1 APOA_HUMAN Apolipoprotein(a) OS=Homo sapiens GN=LPA PE=1 2.00 3.00 ‐1.00 SV=1 IGJ_HUMAN Immunoglobulin J chain OS=Homo sapiens GN=IGJ PE=1 2.00 3.00 ‐1.00 SV=4 HEBP2_HUMAN Heme‐binding protein 2 OS=Homo sapiens GN=HEBP2 3.00 4.00 ‐1.00 PE=1 SV=1 VIME_HUMAN Vimentin OS=Homo sapiens GN=VIM PE=1 SV=4 3.00 4.00 ‐1.00 CH3L1_HUMAN Chitinase‐3‐like protein 1 OS=Homo sapiens 6.00 7.00 ‐1.00 GN=CHI3L1 PE=1 SV=2 COR1A_HUMAN Coronin‐1A OS=Homo sapiens GN=CORO1A PE=1 7.00 8.00 ‐1.00 SV=4 COFA1_HUMAN Collagen alpha‐1(XV) chain OS=Homo sapiens 0.08 1.00 ‐0.92 GN=COL15A1 PE=1 SV=2 APOE_HUMAN Apolipoprotein E OS=Homo sapiens GN=APOE PE=1 0.09 1.00 ‐0.91 SV=1 BROX_HUMAN BRO1 domain‐containing protein BROX OS=Homo 0.13 1.00 ‐0.88 sapiens GN=BROX PE=1 SV=1

© 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 ALDOB_HUMAN Fructose‐bisphosphate aldolase B OS=Homo sapiens 0.14 1.00 ‐0.86 GN=ALDOB PE=1 SV=2 SORL_HUMAN Sortilin‐related receptor OS=Homo sapiens GN=SORL1 0.14 1.00 ‐0.86 PE=1 SV=2 AMPE_HUMAN Glutamyl aminopeptidase OS=Homo sapiens 0.14 1.00 ‐0.86 GN=ENPEP PE=1 SV=3 SDCB1_HUMAN Syntenin‐1 OS=Homo sapiens GN=SDCBP PE=1 SV=1 0.17 1.00 ‐0.83 TENX_HUMAN Tenascin‐X OS=Homo sapiens GN=TNXB PE=1 SV=3 0.50 1.33 ‐0.83 TS101_HUMAN Tumor susceptibility gene 101 protein OS=Homo 0.20 1.00 ‐0.80 sapiens GN=TSG101 PE=1 SV=2 CHM4B_HUMAN Charged multivesicular body protein 4b OS=Homo 0.20 1.00 ‐0.80 sapiens GN=CHMP4B PE=1 SV=1 CADH8_HUMAN Cadherin‐8 OS=Homo sapiens GN=CDH8 PE=1 SV=2 0.20 1.00 ‐0.80 LUM_HUMAN Lumican OS=Homo sapiens GN=LUM PE=1 SV=2 0.20 1.00 ‐0.80 ACE_HUMAN Angiotensin‐converting enzyme OS=Homo sapiens 0.20 1.00 ‐0.80 GN=ACE PE=1 SV=1 LAMP1_HUMAN Lysosome‐associated membrane glycoprotein 1 0.33 1.13 ‐0.79 OS=Homo sapiens GN=LAMP1 PE=1 SV=3 LRC15_HUMAN Leucine‐rich repeat‐containing protein 15 OS=Homo 0.25 1.00 ‐0.75 sapiens GN=LRRC15 PE=1 SV=1 PDC6I_HUMAN Programmed cell death 6‐interacting protein OS=Homo 0.25 1.00 ‐0.75 sapiens GN=PDCD6IP PE=1 SV=1 NHRF1_HUMAN Na(+)/H(+) exchange regulatory cofactor NHE‐RF1 0.25 1.00 ‐0.75 OS=Homo sapiens GN=SLC9A3R1 PE=1 SV=4 TIGD7_HUMAN Tigger transposable element‐derived protein 7 0.25 1.00 ‐0.75 OS=Homo sapiens GN=TIGD7 PE=2 SV=1 THIO_HUMAN Thioredoxin OS=Homo sapiens GN=TXN PE=1 SV=3 0.50 1.25 ‐0.75 CADH6_HUMAN Cadherin‐6 OS=Homo sapiens GN=CDH6 PE=1 SV=1 0.27 1.00 ‐0.73 NEP_HUMAN Neprilysin OS=Homo sapiens GN=MME PE=1 SV=2 0.63 1.33 ‐0.71 GGH_HUMAN Gamma‐glutamyl hydrolase OS=Homo sapiens GN=GGH 0.33 1.00 ‐0.67 PE=1 SV=2 GPVI_HUMAN Platelet glycoprotein VI OS=Homo sapiens GN=GP6 PE=1 0.33 1.00 ‐0.67 SV=2 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 PDZ1I_HUMAN PDZK1‐interacting protein 1 OS=Homo sapiens 0.33 1.00 ‐0.67 GN=PDZK1IP1 PE=1 SV=1 CHM1B_HUMAN Charged multivesicular body protein 1b OS=Homo 0.33 1.00 ‐0.67 sapiens GN=CHMP1B PE=1 SV=1 CSPG2_HUMAN Versican core protein OS=Homo sapiens GN=VCAN 0.33 1.00 ‐0.67 PE=1 SV=3 SC5A2_HUMAN Sodium/glucose cotransporter 2 OS=Homo sapiens 0.33 1.00 ‐0.67 GN=SLC5A2 PE=1 SV=1 RHG23_HUMAN Rho GTPase‐activating protein 23 OS=Homo sapiens 0.33 1.00 ‐0.67 GN=ARHGAP23 PE=1 SV=2 PHP14_HUMAN 14 kDa phosphohistidine phosphatase OS=Homo 0.33 1.00 ‐0.67 sapiens GN=PHPT1 PE=1 SV=1 IF6_HUMAN Eukaryotic translation initiation factor 6 OS=Homo sapiens 0.33 1.00 ‐0.67 GN=EIF6 PE=1 SV=1 NEGR1_HUMAN Neuronal growth regulator 1 OS=Homo sapiens 0.33 1.00 ‐0.67 GN=NEGR1 PE=1 SV=3 ENDD1_HUMAN Endonuclease domain‐containing 1 protein OS=Homo 0.33 1.00 ‐0.67 sapiens GN=ENDOD1 PE=1 SV=2 CDHR2_HUMAN Cadherin‐related family member 2 OS=Homo sapiens 0.33 1.00 ‐0.67 GN=CDHR2 PE=1 SV=2 PPGB_HUMAN Lysosomal protective protein OS=Homo sapiens 0.33 1.00 ‐0.67 GN=CTSA PE=1 SV=2 HORN_HUMAN Hornerin OS=Homo sapiens GN=HRNR PE=1 SV=2 0.38 1.00 ‐0.63 K1C19_HUMAN Keratin, type I cytoskeletal 19 OS=Homo sapiens 0.44 1.06 ‐0.62 GN=KRT19 PE=1 SV=4 CNTN1_HUMAN Contactin‐1 OS=Homo sapiens GN=CNTN1 PE=1 SV=1 0.40 1.00 ‐0.60 K1C16_HUMAN Keratin, type I cytoskeletal 16 OS=Homo sapiens 0.47 1.06 ‐0.59 GN=KRT16 PE=1 SV=4 K1H1_HUMAN Keratin, type I cuticular Ha1 OS=Homo sapiens 0.86 1.44 ‐0.59 GN=KRT31 PE=1 SV=3 K1H2_HUMAN Keratin, type I cuticular Ha2 OS=Homo sapiens 0.86 1.44 ‐0.59 GN=KRT32 PE=1 SV=3 K1C14_HUMAN Keratin, type I cytoskeletal 14 OS=Homo sapiens 0.42 0.97 ‐0.55 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 GN=KRT14 PE=1 SV=4 COCA1_HUMAN Collagen alpha‐1(XII) chain OS=Homo sapiens 0.54 1.09 ‐0.55 GN=COL12A1 PE=1 SV=2 AACT_HUMAN Alpha‐1‐antichymotrypsin OS=Homo sapiens 1.21 1.74 ‐0.54 GN=SERPINA3 PE=1 SV=2 HEG1_HUMAN Protein HEG homolog 1 OS=Homo sapiens GN=HEG1 0.50 1.00 ‐0.50 PE=1 SV=3 NTRI_HUMAN Neurotrimin OS=Homo sapiens GN=NTM PE=1 SV=1 0.50 1.00 ‐0.50 SAP3_HUMAN Ganglioside GM2 activator OS=Homo sapiens 0.50 1.00 ‐0.50 GN=GM2A PE=1 SV=4 NAGAB_HUMAN Alpha‐N‐acetylgalactosaminidase OS=Homo sapiens 0.50 1.00 ‐0.50 GN=NAGA PE=1 SV=2 ICAM2_HUMAN Intercellular adhesion molecule 2 OS=Homo sapiens 0.50 1.00 ‐0.50 GN=ICAM2 PE=1 SV=2 LCAT_HUMAN Phosphatidylcholine‐sterol acyltransferase OS=Homo 0.50 1.00 ‐0.50 sapiens GN=LCAT PE=1 SV=1 GILT_HUMAN Gamma‐interferon‐inducible lysosomal thiol reductase 0.50 1.00 ‐0.50 OS=Homo sapiens GN=IFI30 PE=1 SV=2 SAHH_HUMAN Adenosylhomocysteinase OS=Homo sapiens GN=AHCY 0.50 1.00 ‐0.50 PE=1 SV=4 CHMP5_HUMAN Charged multivesicular body protein 5 OS=Homo 0.50 1.00 ‐0.50 sapiens GN=CHMP5 PE=1 SV=1 NEUR1_HUMAN Sialidase‐1 OS=Homo sapiens GN=NEU1 PE=1 SV=1 0.50 1.00 ‐0.50 GPR56_HUMAN G‐protein coupled receptor 56 OS=Homo sapiens 0.50 1.00 ‐0.50 GN=GPR56 PE=1 SV=2 VPS4B_HUMAN Vacuolar protein sorting‐associated protein 4B 0.50 1.00 ‐0.50 OS=Homo sapiens GN=VPS4B PE=1 SV=2 FREM2_HUMAN FRAS1‐related extracellular matrix protein 2 0.50 1.00 ‐0.50 OS=Homo sapiens GN=FREM2 PE=1 SV=2 EGLN_HUMAN Endoglin OS=Homo sapiens GN=ENG PE=1 SV=2 0.50 1.00 ‐0.50 PEX6_HUMAN Peroxisome assembly factor 2 OS=Homo sapiens 0.50 1.00 ‐0.50 GN=PEX6 PE=1 SV=2 MMRN1_HUMAN Multimerin‐1 OS=Homo sapiens GN=MMRN1 PE=1 0.50 1.00 ‐0.50 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 SV=3 CSPG5_HUMAN Chondroitin sulfate proteoglycan 5 OS=Homo sapiens 0.50 1.00 ‐0.50 GN=CSPG5 PE=1 SV=3 GRN_HUMAN Granulins OS=Homo sapiens GN=GRN PE=1 SV=2 0.50 1.00 ‐0.50 VP26B_HUMAN Vacuolar protein sorting‐associated protein 26B 0.50 1.00 ‐0.50 OS=Homo sapiens GN=VPS26B PE=1 SV=2 S6A19_HUMAN Sodium‐dependent neutral amino acid transporter 0.50 1.00 ‐0.50 B(0)AT1 OS=Homo sapiens GN=SLC6A19 PE=1 SV=1 COTL1_HUMAN Coactosin‐like protein OS=Homo sapiens GN=COTL1 0.50 1.00 ‐0.50 PE=1 SV=3 FLNB_HUMAN Filamin‐B OS=Homo sapiens GN=FLNB PE=1 SV=2 0.50 1.00 ‐0.50 TPP1_HUMAN Tripeptidyl‐peptidase 1 OS=Homo sapiens GN=TPP1 0.50 1.00 ‐0.50 PE=1 SV=2 AL1A1_HUMAN Retinal dehydrogenase 1 OS=Homo sapiens 0.50 1.00 ‐0.50 GN=ALDH1A1 PE=1 SV=2 MYLK_HUMAN Myosin light chain kinase, smooth muscle OS=Homo 0.50 1.00 ‐0.50 sapiens GN=MYLK PE=1 SV=4 NAPSA_HUMAN Napsin‐A OS=Homo sapiens GN=NAPSA PE=1 SV=1 0.50 1.00 ‐0.50 CATB_HUMAN Cathepsin B OS=Homo sapiens GN=CTSB PE=1 SV=3 0.50 1.00 ‐0.50 LYPD2_HUMAN Ly6/PLAUR domain‐containing protein 2 OS=Homo 0.50 1.00 ‐0.50 sapiens GN=LYPD2 PE=2 SV=1 HBB_HUMAN Hemoglobin subunit beta OS=Homo sapiens GN=HBB 1.50 2.00 ‐0.50 PE=1 SV=2 ANXA5_HUMAN Annexin A5 OS=Homo sapiens GN=ANXA5 PE=1 SV=2 1.50 2.00 ‐0.50 GPC5C_HUMAN G‐protein coupled receptor family C group 5 member 0.03 0.50 ‐0.47 C OS=Homo sapiens GN=GPRC5C PE=1 SV=2 K1C9_HUMAN Keratin, type I cytoskeletal 9 OS=Homo sapiens 0.55 1.01 ‐0.46 GN=KRT9 PE=1 SV=3 FLNA_HUMAN Filamin‐A OS=Homo sapiens GN=FLNA PE=1 SV=4 0.67 1.13 ‐0.46 GPC5B_HUMAN G‐protein coupled receptor family C group 5 member 0.06 0.50 ‐0.44 B OS=Homo sapiens GN=GPRC5B PE=2 SV=2 KV402_HUMAN Ig kappa chain V‐IV region Len OS=Homo sapiens PE=1 0.45 0.88 ‐0.43 SV=2 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 KV106_HUMAN Ig kappa chain V‐I region EU OS=Homo sapiens PE=1 1.33 1.75 ‐0.42 SV=1 FURIN_HUMAN Furin OS=Homo sapiens GN=FURIN PE=1 SV=2 0.60 1.00 ‐0.40 LV106_HUMAN Ig lambda chain V‐I region WAH OS=Homo sapiens 0.60 1.00 ‐0.40 PE=1 SV=1 THBG_HUMAN Thyroxine‐binding globulin OS=Homo sapiens 0.50 0.89 ‐0.39 GN=SERPINA7 PE=1 SV=2 KV307_HUMAN Ig kappa chain V‐III region GOL OS=Homo sapiens PE=1 0.62 1.00 ‐0.38 SV=1 K1C15_HUMAN Keratin, type I cytoskeletal 15 OS=Homo sapiens 0.63 1.00 ‐0.37 GN=KRT15 PE=1 SV=3 UBB_HUMAN Polyubiquitin‐B OS=Homo sapiens GN=UBB PE=1 SV=1 0.92 1.27 ‐0.35 UBC_HUMAN Polyubiquitin‐C OS=Homo sapiens GN=UBC PE=1 SV=2 0.92 1.27 ‐0.35 RS27A_HUMAN Ubiquitin‐40S ribosomal protein S27a OS=Homo 0.92 1.27 ‐0.35 sapiens GN=RPS27A PE=1 SV=2 RL40_HUMAN Ubiquitin‐60S ribosomal protein L40 OS=Homo sapiens 0.92 1.27 ‐0.35 GN=UBA52 PE=1 SV=2 OSCAR_HUMAN Osteoclast‐associated immunoglobulin‐like receptor 0.17 0.50 ‐0.33 OS=Homo sapiens GN=OSCAR PE=2 SV=3 CILP2_HUMAN Cartilage intermediate layer protein 2 OS=Homo 0.17 0.50 ‐0.33 sapiens GN=CILP2 PE=2 SV=2 EFNB1_HUMAN Ephrin‐B1 OS=Homo sapiens GN=EFNB1 PE=1 SV=1 0.67 1.00 ‐0.33 PGCB_HUMAN Brevican core protein OS=Homo sapiens GN=BCAN 0.67 1.00 ‐0.33 PE=1 SV=2 FBLN2_HUMAN Fibulin‐2 OS=Homo sapiens GN=FBLN2 PE=1 SV=2 0.67 1.00 ‐0.33 PLCA_HUMAN 1‐acyl‐sn‐glycerol‐3‐phosphate acyltransferase alpha 0.67 1.00 ‐0.33 OS=Homo sapiens GN=AGPAT1 PE=2 SV=2 SLUR1_HUMAN Secreted Ly‐6/uPAR‐related protein 1 OS=Homo 1.00 1.33 ‐0.33 sapiens GN=SLURP1 PE=1 SV=2 ASPG_HUMAN N(4)‐(beta‐N‐acetylglucosaminyl)‐L‐asparaginase 1.00 1.33 ‐0.33 OS=Homo sapiens GN=AGA PE=1 SV=2 COIA1_HUMAN Collagen alpha‐1(XVIII) chain OS=Homo sapiens 0.20 0.50 ‐0.30 GN=COL18A1 PE=1 SV=5 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 MADCA_HUMAN Mucosal addressin cell adhesion molecule 1 0.20 0.50 ‐0.30 OS=Homo sapiens GN=MADCAM1 PE=1 SV=2 CADH1_HUMAN Cadherin‐1 OS=Homo sapiens GN=CDH1 PE=1 SV=3 0.35 0.64 ‐0.29 CBPA4_HUMAN Carboxypeptidase A4 OS=Homo sapiens GN=CPA4 1.00 1.29 ‐0.29 PE=1 SV=2 ASAH1_HUMAN Acid ceramidase OS=Homo sapiens GN=ASAH1 PE=1 0.25 0.50 ‐0.25 SV=5 PLMN_HUMAN Plasminogen OS=Homo sapiens GN=PLG PE=1 SV=2 0.50 0.75 ‐0.25 HV103_HUMAN Ig heavy chain V‐I region V35 OS=Homo sapiens PE=1 0.75 1.00 ‐0.25 SV=1 CO6A3_HUMAN Collagen alpha‐3(VI) chain OS=Homo sapiens 0.48 0.73 ‐0.25 GN=COL6A3 PE=1 SV=5 COEA1_HUMAN Collagen alpha‐1(XIV) chain OS=Homo sapiens 0.29 0.50 ‐0.21 GN=COL14A1 PE=1 SV=3 PI16_HUMAN Peptidase inhibitor 16 OS=Homo sapiens GN=PI16 PE=1 0.79 1.00 ‐0.21 SV=1 SODC_HUMAN Superoxide dismutase [Cu‐Zn] OS=Homo sapiens 2.00 2.20 ‐0.20 GN=SOD1 PE=1 SV=2 CALL5_HUMAN Calmodulin‐like protein 5 OS=Homo sapiens 1.00 1.20 ‐0.20 GN=CALML5 PE=1 SV=2 K22E_HUMAN Keratin, type II cytoskeletal 2 epidermal OS=Homo 0.38 0.57 ‐0.19 sapiens GN=KRT2 PE=1 SV=2 LG3BP_HUMAN Galectin‐3‐binding protein OS=Homo sapiens 0.59 0.76 ‐0.17 GN=LGALS3BP PE=1 SV=1 BASI_HUMAN Basigin OS=Homo sapiens GN=BSG PE=1 SV=2 1.33 1.50 ‐0.17 EPHB4_HUMAN Ephrin type‐B receptor 4 OS=Homo sapiens GN=EPHB4 0.33 0.50 ‐0.17 PE=1 SV=2 LTBP2_HUMAN Latent‐transforming growth factor beta‐binding 0.33 0.50 ‐0.17 protein 2 OS=Homo sapiens GN=LTBP2 PE=1 SV=3 CYTA_HUMAN Cystatin‐A OS=Homo sapiens GN=CSTA PE=1 SV=1 0.81 0.97 ‐0.16 FILA2_HUMAN Filaggrin‐2 OS=Homo sapiens GN=FLG2 PE=1 SV=1 0.25 0.41 ‐0.16 GGT1_HUMAN Gamma‐glutamyltranspeptidase 1 OS=Homo sapiens 0.22 0.38 ‐0.15 GN=GGT1 PE=1 SV=2 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 GNS_HUMAN N‐acetylglucosamine‐6‐sulfatase OS=Homo sapiens 0.50 0.65 ‐0.15 GN=GNS PE=1 SV=3 NTF2_HUMAN Nuclear transport factor 2 OS=Homo sapiens 0.60 0.75 ‐0.15 GN=NUTF2 PE=1 SV=1 ODO2_HUMAN Dihydrolipoyllysine‐residue succinyltransferase 0.20 0.33 ‐0.13 component of 2‐oxoglutarate dehydrogenase complex, mitochondrial OS=Homo sapiens GN=DLST PE=1 SV=3 KV309_HUMAN Ig kappa chain V‐III region VG (Fragment) OS=Homo 0.56 0.67 ‐0.11 sapiens PE=1 SV=1 CLUS_HUMAN Clusterin OS=Homo sapiens GN=CLU PE=1 SV=1 0.03 0.14 ‐0.11 RADI_HUMAN Radixin OS=Homo sapiens GN=RDX PE=1 SV=1 0.40 0.50 ‐0.10 R4RL2_HUMAN Reticulon‐4 receptor‐like 2 OS=Homo sapiens 0.40 0.50 ‐0.10 GN=RTN4RL2 PE=1 SV=1 K1C10_HUMAN Keratin, type I cytoskeletal 10 OS=Homo sapiens 0.62 0.72 ‐0.10 GN=KRT10 PE=1 SV=6 IST1_HUMAN IST1 homolog OS=Homo sapiens GN=KIAA0174 PE=1 0.11 0.20 ‐0.09 SV=1 CATC_HUMAN Dipeptidyl peptidase 1 OS=Homo sapiens GN=CTSC 0.11 0.20 ‐0.09 PE=1 SV=1 BT2A1_HUMAN Butyrophilin subfamily 2 member A1 OS=Homo 0.48 0.57 ‐0.09 sapiens GN=BTN2A1 PE=1 SV=3 CADH2_HUMAN Cadherin‐2 OS=Homo sapiens GN=CDH2 PE=1 SV=4 0.33 0.42 ‐0.08 PTPRJ_HUMAN Receptor‐type tyrosine‐protein phosphatase eta 0.25 0.33 ‐0.08 OS=Homo sapiens GN=PTPRJ PE=1 SV=3 BHMT1_HUMAN Betaine‐‐homocysteine S‐methyltransferase 1 0.25 0.33 ‐0.08 OS=Homo sapiens GN=BHMT PE=1 SV=2 PCP_HUMAN Lysosomal Pro‐X carboxypeptidase OS=Homo sapiens 0.25 0.33 ‐0.08 GN=PRCP PE=1 SV=1 VASN_HUMAN Vasorin OS=Homo sapiens GN=VASN PE=1 SV=1 0.28 0.35 ‐0.07 TENXA_HUMAN Putative tenascin‐XA OS=Homo sapiens GN=TNXA 0.43 0.50 ‐0.07 PE=5 SV=2 AMPN_HUMAN Aminopeptidase N OS=Homo sapiens GN=ANPEP PE=1 0.45 0.52 ‐0.07 SV=4 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 PROZ_HUMAN Vitamin K‐dependent protein Z OS=Homo sapiens 0.20 0.25 ‐0.05 GN=PROZ PE=1 SV=2 DPEP1_HUMAN Dipeptidase 1 OS=Homo sapiens GN=DPEP1 PE=1 SV=3 0.45 0.50 ‐0.05 A1AT_HUMAN Alpha‐1‐antitrypsin OS=Homo sapiens GN=SERPINA1 4.02 4.06 ‐0.04 PE=1 SV=3 K2C1_HUMAN Keratin, type II cytoskeletal 1 OS=Homo sapiens 0.77 0.81 ‐0.04 GN=KRT1 PE=1 SV=6 CD248_HUMAN Endosialin OS=Homo sapiens GN=CD248 PE=1 SV=1 0.21 0.25 ‐0.04 CPVL_HUMAN Probable serine carboxypeptidase CPVL OS=Homo 0.13 0.14 ‐0.02 sapiens GN=CPVL PE=1 SV=2 MGA_HUMAN Maltase‐glucoamylase, intestinal OS=Homo sapiens 0.25 0.27 ‐0.02 GN=MGAM PE=1 SV=5 LYAG_HUMAN Lysosomal alpha‐glucosidase OS=Homo sapiens 0.15 0.15 ‐0.01 GN=GAA PE=1 SV=3 CO2A1_HUMAN Collagen alpha‐1(II) chain OS=Homo sapiens 0.88 0.89 ‐0.01 GN=COL2A1 PE=1 SV=3 LRP2_HUMAN Low‐density lipoprotein receptor‐related protein 2 0.13 0.13 0.00 OS=Homo sapiens GN=LRP2 PE=1 SV=3 PVRL2_HUMAN Poliovirus receptor‐related protein 2 OS=Homo 0.20 0.20 0.00 sapiens GN=PVRL2 PE=1 SV=1 CATL1_HUMAN Cathepsin L1 OS=Homo sapiens GN=CTSL1 PE=1 SV=2 0.25 0.25 0.00 MANBA_HUMAN Beta‐mannosidase OS=Homo sapiens GN=MANBA 0.33 0.33 0.00 PE=1 SV=3 DNS2A_HUMAN Deoxyribonuclease‐2‐alpha OS=Homo sapiens 0.50 0.50 0.00 GN=DNASE2 PE=1 SV=2 PXDC2_HUMAN Plexin domain‐containing protein 2 OS=Homo sapiens 0.50 0.50 0.00 GN=PLXDC2 PE=1 SV=1 THRB_HUMAN Prothrombin OS=Homo sapiens GN=F2 PE=1 SV=2 1.00 1.00 0.00 PTPRD_HUMAN Receptor‐type tyrosine‐protein phosphatase delta 1.00 1.00 0.00 OS=Homo sapiens GN=PTPRD PE=1 SV=2 PCD16_HUMAN Protocadherin‐16 OS=Homo sapiens GN=DCHS1 PE=2 1.00 1.00 0.00 SV=1 PRKDC_HUMAN DNA‐dependent protein kinase catalytic subunit 1.00 1.00 0.00 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 OS=Homo sapiens GN=PRKDC PE=1 SV=3 ANXA4_HUMAN Annexin A4 OS=Homo sapiens GN=ANXA4 PE=1 SV=4 1.00 1.00 0.00 PTK7_HUMAN Tyrosine‐protein kinase‐like 7 OS=Homo sapiens 1.00 1.00 0.00 GN=PTK7 PE=1 SV=2 CFAI_HUMAN Complement factor I OS=Homo sapiens GN=CFI PE=1 1.00 1.00 0.00 SV=1 SHSA5_HUMAN Protein shisa‐5 OS=Homo sapiens GN=SHISA5 PE=2 1.00 1.00 0.00 SV=1 NEO1_HUMAN Neogenin OS=Homo sapiens GN=NEO1 PE=1 SV=2 1.00 1.00 0.00 CEL3B_HUMAN Chymotrypsin‐like elastase family member 3B 1.00 1.00 0.00 OS=Homo sapiens GN=CELA3B PE=1 SV=2 CEL3A_HUMAN Chymotrypsin‐like elastase family member 3A 1.00 1.00 0.00 OS=Homo sapiens GN=CELA3A PE=1 SV=3 CREG1_HUMAN Protein CREG1 OS=Homo sapiens GN=CREG1 PE=1 1.00 1.00 0.00 SV=1 PTPRN_HUMAN Receptor‐type tyrosine‐protein phosphatase‐like N 1.00 1.00 0.00 OS=Homo sapiens GN=PTPRN PE=1 SV=1 KRT84_HUMAN Keratin, type II cuticular Hb4 OS=Homo sapiens 1.00 1.00 0.00 GN=KRT84 PE=1 SV=2 TRY2_HUMAN Trypsin‐2 OS=Homo sapiens GN=PRSS2 PE=1 SV=1 1.00 1.00 0.00 PVRL1_HUMAN Poliovirus receptor‐related protein 1 OS=Homo 1.00 1.00 0.00 sapiens GN=PVRL1 PE=1 SV=3 HMCN2_HUMAN Hemicentin‐2 OS=Homo sapiens GN=HMCN2 PE=2 1.00 1.00 0.00 SV=2 TYRO3_HUMAN Tyrosine‐protein kinase receptor TYRO3 OS=Homo 1.00 1.00 0.00 sapiens GN=TYRO3 PE=1 SV=1 KV110_HUMAN Ig kappa chain V‐I region HK102 (Fragment) OS=Homo 1.00 1.00 0.00 sapiens GN=IGKV1‐5 PE=4 SV=1 CO1A1_HUMAN Collagen alpha‐1(I) chain OS=Homo sapiens 1.00 1.00 0.00 GN=COL1A1 PE=1 SV=5 PXDC1_HUMAN Plexin domain‐containing protein 1 OS=Homo sapiens 1.00 1.00 0.00 GN=PLXDC1 PE=1 SV=2 TSP3_HUMAN Thrombospondin‐3 OS=Homo sapiens GN=THBS3 PE=1 1.00 1.00 0.00 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 SV=1 PSB3_HUMAN Proteasome subunit beta type‐3 OS=Homo sapiens 1.00 1.00 0.00 GN=PSMB3 PE=1 SV=2 PGFRB_HUMAN Beta‐type platelet‐derived growth factor receptor 1.00 1.00 0.00 OS=Homo sapiens GN=PDGFRB PE=1 SV=1 8ODP_HUMAN 7,8‐dihydro‐8‐oxoguanine triphosphatase OS=Homo 1.00 1.00 0.00 sapiens GN=NUDT1 PE=1 SV=3 EPHB2_HUMAN Ephrin type‐B receptor 2 OS=Homo sapiens GN=EPHB2 1.00 1.00 0.00 PE=1 SV=5 XYLT1_HUMAN Xylosyltransferase 1 OS=Homo sapiens GN=XYLT1 PE=1 1.00 1.00 0.00 SV=1 DOPD_HUMAN D‐dopachrome decarboxylase OS=Homo sapiens 1.00 1.00 0.00 GN=DDT PE=1 SV=3 COF1_HUMAN Cofilin‐1 OS=Homo sapiens GN=CFL1 PE=1 SV=3 1.00 1.00 0.00 PDCD6_HUMAN Programmed cell death protein 6 OS=Homo sapiens 1.00 1.00 0.00 GN=PDCD6 PE=1 SV=1 CD33_HUMAN Myeloid cell surface antigen CD33 OS=Homo sapiens 1.00 1.00 0.00 GN=CD33 PE=1 SV=2 LFA3_HUMAN Lymphocyte function‐associated antigen 3 OS=Homo 1.00 1.00 0.00 sapiens GN=CD58 PE=1 SV=1 PTPRF_HUMAN Receptor‐type tyrosine‐protein phosphatase F 1.00 1.00 0.00 OS=Homo sapiens GN=PTPRF PE=1 SV=2 PRND_HUMAN Prion‐like protein doppel OS=Homo sapiens GN=PRND 1.00 1.00 0.00 PE=1 SV=2 TENR_HUMAN Tenascin‐R OS=Homo sapiens GN=TNR PE=1 SV=3 1.00 1.00 0.00 PGCA_HUMAN Aggrecan core protein OS=Homo sapiens GN=ACAN 1.00 1.00 0.00 PE=1 SV=2 COBA1_HUMAN Collagen alpha‐1(XI) chain OS=Homo sapiens 1.00 1.00 0.00 GN=COL11A1 PE=1 SV=4 SLIK1_HUMAN SLIT and NTRK‐like protein 1 OS=Homo sapiens 1.00 1.00 0.00 GN=SLITRK1 PE=1 SV=2 KV119_HUMAN Ig kappa chain V‐I region Wes OS=Homo sapiens PE=1 1.00 1.00 0.00 SV=1 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 PENK_HUMAN Proenkephalin‐A OS=Homo sapiens GN=PENK PE=1 1.00 1.00 0.00 SV=1 TUT4_HUMAN Terminal uridylyltransferase 4 OS=Homo sapiens 1.00 1.00 0.00 GN=ZCCHC11 PE=1 SV=3 NONO_HUMAN Non‐POU domain‐containing octamer‐binding protein 1.00 1.00 0.00 OS=Homo sapiens GN=NONO PE=1 SV=4 NEUS_HUMAN Neuroserpin OS=Homo sapiens GN=SERPINI1 PE=1 1.00 1.00 0.00 SV=1 LAMA3_HUMAN Laminin subunit alpha‐3 OS=Homo sapiens 1.00 1.00 0.00 GN=LAMA3 PE=1 SV=2 CO5A3_HUMAN Collagen alpha‐3(V) chain OS=Homo sapiens 1.00 1.00 0.00 GN=COL5A3 PE=1 SV=3 FBLN1_HUMAN Fibulin‐1 OS=Homo sapiens GN=FBLN1 PE=1 SV=4 1.00 1.00 0.00 PSA3_HUMAN Proteasome subunit alpha type‐3 OS=Homo sapiens 1.00 1.00 0.00 GN=PSMA3 PE=1 SV=2 SDK1_HUMAN Protein sidekick‐1 OS=Homo sapiens GN=SDK1 PE=1 1.00 1.00 0.00 SV=3 TRFM_HUMAN Melanotransferrin OS=Homo sapiens GN=MFI2 PE=1 1.00 1.00 0.00 SV=1 LY6H_HUMAN Lymphocyte antigen 6H OS=Homo sapiens GN=LY6H 1.00 1.00 0.00 PE=2 SV=1 MATN4_HUMAN Matrilin‐4 OS=Homo sapiens GN=MATN4 PE=1 SV=3 1.00 1.00 0.00 TRY1_HUMAN Trypsin‐1 OS=Homo sapiens GN=PRSS1 PE=1 SV=1 1.00 1.00 0.00 IL1RA_HUMAN Interleukin‐1 receptor antagonist protein OS=Homo 1.00 1.00 0.00 sapiens GN=IL1RN PE=1 SV=1 RB15B_HUMAN Putative RNA‐binding protein 15B OS=Homo sapiens 1.00 1.00 0.00 GN=RBM15B PE=1 SV=3 CHL1_HUMAN Neural cell adhesion molecule L1‐like protein OS=Homo 1.00 1.00 0.00 sapiens GN=CHL1 PE=1 SV=3 CF120_HUMAN UPF0669 protein C6orf120 OS=Homo sapiens 1.00 1.00 0.00 GN=C6orf120 PE=1 SV=1 MITD1_HUMAN MIT domain‐containing protein 1 OS=Homo sapiens 1.00 1.00 0.00 GN=MITD1 PE=1 SV=1 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 CTL4_HUMAN Choline transporter‐like protein 4 OS=Homo sapiens 1.00 1.00 0.00 GN=SLC44A4 PE=2 SV=2 TRC2L_HUMAN Putative short transient receptor potential channel 2‐ 1.00 1.00 0.00 like protein OS=Homo sapiens PE=5 SV=1 H15_HUMAN Histone H1.5 OS=Homo sapiens GN=HIST1H1B PE=1 SV=3 1.00 1.00 0.00 PLXB1_HUMAN Plexin‐B1 OS=Homo sapiens GN=PLXNB1 PE=1 SV=3 1.00 1.00 0.00 CO1A2_HUMAN Collagen alpha‐2(I) chain OS=Homo sapiens 1.00 1.00 0.00 GN=COL1A2 PE=1 SV=7 KIRR1_HUMAN Kin of IRRE‐like protein 1 OS=Homo sapiens GN=KIRREL 1.00 1.00 0.00 PE=1 SV=2 VGF_HUMAN Neurosecretory protein VGF OS=Homo sapiens GN=VGF 1.00 1.00 0.00 PE=1 SV=2 ELFN1_HUMAN Extracellular leucine‐rich repeat and fibronectin type‐ 1.00 1.00 0.00 III domain‐containing protein 1 OS=Homo sapiens GN=ELFN1 PE=2 SV=1 MA2A1_HUMAN Alpha‐mannosidase 2 OS=Homo sapiens 1.00 1.00 0.00 GN=MAN2A1 PE=1 SV=2 PSB8_HUMAN Proteasome subunit beta type‐8 OS=Homo sapiens 1.00 1.00 0.00 GN=PSMB8 PE=1 SV=2 MA2B1_HUMAN Lysosomal alpha‐mannosidase OS=Homo sapiens 1.00 1.00 0.00 GN=MAN2B1 PE=1 SV=3 IFT74_HUMAN Intraflagellar transport protein 74 homolog OS=Homo 1.00 1.00 0.00 sapiens GN=IFT74 PE=2 SV=1 ANXA6_HUMAN Annexin A6 OS=Homo sapiens GN=ANXA6 PE=1 SV=3 1.00 1.00 0.00 PGFRA_HUMAN Alpha‐type platelet‐derived growth factor receptor 1.00 1.00 0.00 OS=Homo sapiens GN=PDGFRA PE=1 SV=1 ATNG_HUMAN Sodium/potassium‐transporting ATPase subunit 1.00 1.00 0.00 gamma OS=Homo sapiens GN=FXYD2 PE=1 SV=3 F125B_HUMAN Multivesicular body subunit 12B OS=Homo sapiens 1.00 1.00 0.00 GN=FAM125B PE=1 SV=2 UK114_HUMAN Ribonuclease UK114 OS=Homo sapiens GN=HRSP12 1.00 1.00 0.00 PE=1 SV=1 I10R2_HUMAN Interleukin‐10 receptor subunit beta OS=Homo sapiens 1.00 1.00 0.00 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 GN=IL10RB PE=1 SV=2 CPNS1_HUMAN Calpain small subunit 1 OS=Homo sapiens GN=CAPNS1 1.00 1.00 0.00 PE=1 SV=1 TC1D3_HUMAN Tctex1 domain‐containing protein 3 OS=Homo sapiens 1.00 1.00 0.00 GN=TCTE3 PE=1 SV=1 CLC7A_HUMAN C‐type lectin domain family 7 member A OS=Homo 1.00 1.00 0.00 sapiens GN=CLEC7A PE=1 SV=1 RIPK4_HUMAN Receptor‐interacting serine/threonine‐protein kinase 4 1.00 1.00 0.00 OS=Homo sapiens GN=RIPK4 PE=1 SV=1 PKP4_HUMAN Plakophilin‐4 OS=Homo sapiens GN=PKP4 PE=1 SV=1 1.00 1.00 0.00 BTNL3_HUMAN Butyrophilin‐like protein 3 OS=Homo sapiens 1.00 1.00 0.00 GN=BTNL3 PE=2 SV=2 COG7_HUMAN Conserved oligomeric Golgi complex subunit 7 1.00 1.00 0.00 OS=Homo sapiens GN=COG7 PE=1 SV=1 TSEAR_HUMAN Protein TSPEAR OS=Homo sapiens GN=TSPEAR PE=2 1.00 1.00 0.00 SV=2 MUC5A_HUMAN Mucin‐5AC (Fragments) OS=Homo sapiens 1.00 1.00 0.00 GN=MUC5AC PE=1 SV=3 PAPP2_HUMAN Pappalysin‐2 OS=Homo sapiens GN=PAPPA2 PE=1 1.00 1.00 0.00 SV=4 A2LD1_HUMAN Gamma‐glutamylaminecyclotransferase OS=Homo 1.00 1.00 0.00 sapiens GN=A2LD1 PE=1 SV=2 PEPD_HUMAN Xaa‐Pro dipeptidase OS=Homo sapiens GN=PEPD PE=1 1.00 1.00 0.00 SV=3 TSP1_HUMAN Thrombospondin‐1 OS=Homo sapiens GN=THBS1 PE=1 1.00 1.00 0.00 SV=2 CLIC1_HUMAN Chloride intracellular channel protein 1 OS=Homo 1.00 1.00 0.00 sapiens GN=CLIC1 PE=1 SV=4 PSB9_HUMAN Proteasome subunit beta type‐9 OS=Homo sapiens 1.00 1.00 0.00 GN=PSMB9 PE=1 SV=2 SLUR2_HUMAN Secreted Ly‐6/uPAR‐related protein 2 OS=Homo 1.00 1.00 0.00 sapiens GN=SLURP2 PE=2 SV=1 GBG12_HUMAN Guanine nucleotide‐binding protein G(I)/G(S)/G(O) 1.00 1.00 0.00 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 subunit gamma‐12 OS=Homo sapiens GN=GNG12 PE=1 SV=3 K1529_HUMAN Uncharacterized protein KIAA1529 OS=Homo sapiens 1.00 1.00 0.00 GN=KIAA1529 PE=1 SV=2 IQCG_HUMAN IQ domain‐containing protein G OS=Homo sapiens 1.00 1.00 0.00 GN=IQCG PE=2 SV=1 F169A_HUMAN Protein FAM169A OS=Homo sapiens GN=FAM169A 1.00 1.00 0.00 PE=1 SV=2 FOXH1_HUMAN Forkhead box protein H1 OS=Homo sapiens 1.00 1.00 0.00 GN=FOXH1 PE=1 SV=1 FA12_HUMAN Coagulation factor XII OS=Homo sapiens GN=F12 PE=1 1.00 1.00 0.00 SV=2 CRUM2_HUMAN Crumbs homolog 2 OS=Homo sapiens GN=CRB2 PE=2 1.00 1.00 0.00 SV=2 VPS8_HUMAN Vacuolar protein sorting‐associated protein 8 homolog 1.00 1.00 0.00 OS=Homo sapiens GN=VPS8 PE=1 SV=3 SPRC_HUMAN SPARC OS=Homo sapiens GN=SPARC PE=1 SV=1 1.00 1.00 0.00 GRIK2_HUMAN Glutamate receptor, ionotropic kainate 2 OS=Homo 1.00 1.00 0.00 sapiens GN=GRIK2 PE=1 SV=1 EFNA1_HUMAN Ephrin‐A1 OS=Homo sapiens GN=EFNA1 PE=1 SV=2 1.00 1.00 0.00 TRHDE_HUMAN Thyrotropin‐releasing hormone‐degrading 1.00 1.00 0.00 ectoenzyme OS=Homo sapiens GN=TRHDE PE=2 SV=1 CB079_HUMAN Uncharacterized protein C2orf79 OS=Homo sapiens 1.00 1.00 0.00 GN=C2orf79 PE=1 SV=1 CBPB1_HUMAN Carboxypeptidase B OS=Homo sapiens GN=CPB1 PE=1 1.00 1.00 0.00 SV=4 CTHR1_HUMAN Collagen triple helix repeat‐containing protein 1 1.00 1.00 0.00 OS=Homo sapiens GN=CTHRC1 PE=1 SV=1 CRUM1_HUMAN Crumbs homolog 1 OS=Homo sapiens GN=CRB1 PE=1 1.00 1.00 0.00 SV=2 DGCR8_HUMAN Microprocessor complex subunit DGCR8 OS=Homo 1.00 1.00 0.00 sapiens GN=DGCR8 PE=1 SV=1 HNRPR_HUMAN Heterogeneous nuclear ribonucleoprotein R 1.00 1.00 0.00 OS=Homo sapiens GN=HNRNPR PE=1 SV=1 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 CATL2_HUMAN Cathepsin L2 OS=Homo sapiens GN=CTSL2 PE=1 SV=2 1.00 1.00 0.00 COX7R_HUMAN Cytochrome c oxidase subunit 7A‐related protein, 1.00 1.00 0.00 mitochondrial OS=Homo sapiens GN=COX7A2L PE=1 SV=2 CHODL_HUMAN Chondrolectin OS=Homo sapiens GN=CHODL PE=2 1.00 1.00 0.00 SV=2 SCN4A_HUMAN Sodium channel protein type 4 subunit alpha 1.00 1.00 0.00 OS=Homo sapiens GN=SCN4A PE=1 SV=4 SRC8_HUMAN Src substrate cortactin OS=Homo sapiens GN=CTTN 1.00 1.00 0.00 PE=1 SV=2 ATG13_HUMAN Autophagy‐related protein 13 OS=Homo sapiens 1.00 1.00 0.00 GN=ATG13 PE=1 SV=1 SPTA2_HUMAN Spectrin alpha chain, brain OS=Homo sapiens 1.00 1.00 0.00 GN=SPTAN1 PE=1 SV=3 GOLM1_HUMAN Golgi membrane protein 1 OS=Homo sapiens 1.00 1.00 0.00 GN=GOLM1 PE=1 SV=1 RRP5_HUMAN Protein RRP5 homolog OS=Homo sapiens GN=PDCD11 1.00 1.00 0.00 PE=1 SV=3 BID_HUMAN BH3‐interacting domain death agonist OS=Homo sapiens 1.00 1.00 0.00 GN=BID PE=1 SV=1 CNOT1_HUMAN CCR4‐NOT transcription complex subunit 1 OS=Homo 1.00 1.00 0.00 sapiens GN=CNOT1 PE=1 SV=2 K0494_HUMAN EF‐hand domain‐containing protein KIAA0494 1.00 1.00 0.00 OS=Homo sapiens GN=KIAA0494 PE=1 SV=1 APOM_HUMAN Apolipoprotein M OS=Homo sapiens GN=APOM PE=1 1.00 1.00 0.00 SV=2 CATS_HUMAN Cathepsin S OS=Homo sapiens GN=CTSS PE=1 SV=3 1.00 1.00 0.00 CPPED_HUMAN Calcineurin‐like phosphoesterase domain‐containing 1.00 1.00 0.00 protein 1 OS=Homo sapiens GN=CPPED1 PE=1 SV=2 ENPP6_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase 1.00 1.00 0.00 family member 6 OS=Homo sapiens GN=ENPP6 PE=2 SV=2 LMTK1_HUMAN Serine/threonine‐protein kinase LMTK1 OS=Homo 1.00 1.00 0.00 sapiens GN=AATK PE=1 SV=2 ADIPO_HUMAN Adiponectin OS=Homo sapiens GN=ADIPOQ PE=1 SV=1 1.00 1.00 0.00 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 GSHB_HUMAN Glutathione synthetase OS=Homo sapiens GN=GSS 1.00 1.00 0.00 PE=1 SV=1 SPB13_HUMAN Serpin B13 OS=Homo sapiens GN=SERPINB13 PE=2 1.00 1.00 0.00 SV=2 AT12A_HUMAN Potassium‐transporting ATPase alpha chain 2 1.00 1.00 0.00 OS=Homo sapiens GN=ATP12A PE=2 SV=3 ULK4_HUMAN Serine/threonine‐protein kinase ULK4 OS=Homo 1.00 1.00 0.00 sapiens GN=ULK4 PE=2 SV=2 KCTD4_HUMAN BTB/POZ domain‐containing protein KCTD4 OS=Homo 1.00 1.00 0.00 sapiens GN=KCTD4 PE=2 SV=2 RHCG_HUMAN Ammonium transporter Rh type C OS=Homo sapiens 1.00 1.00 0.00 GN=RHCG PE=1 SV=1 PACE1_HUMAN Protein‐associating with the carboxyl‐terminal domain 1.00 1.00 0.00 of ezrin OS=Homo sapiens GN=SCYL3 PE=1 SV=3 CYBR1_HUMAN Cytochrome b reductase 1 OS=Homo sapiens 1.00 1.00 0.00 GN=CYBRD1 PE=1 SV=1 HMGB2_HUMAN High mobility group protein B2 OS=Homo sapiens 1.00 1.00 0.00 GN=HMGB2 PE=1 SV=2 KV203_HUMAN Ig kappa chain V‐II region MIL OS=Homo sapiens PE=1 1.00 1.00 0.00 SV=1 CH10_HUMAN 10 kDa heat shock protein, mitochondrial OS=Homo 1.00 1.00 0.00 sapiens GN=HSPE1 PE=1 SV=2 FA8_HUMAN Coagulation factor VIII OS=Homo sapiens GN=F8 PE=1 1.00 1.00 0.00 SV=1 PSA7_HUMAN Proteasome subunit alpha type‐7 OS=Homo sapiens 1.00 1.00 0.00 GN=PSMA7 PE=1 SV=1 K1024_HUMAN UPF0258 protein KIAA1024 OS=Homo sapiens 1.00 1.00 0.00 GN=KIAA1024 PE=2 SV=3 CELF6_HUMAN CUGBP Elav‐like family member 6 OS=Homo sapiens 1.00 1.00 0.00 GN=CELF6 PE=1 SV=1 RPGF3_HUMAN Rap guanine nucleotide exchange factor 3 OS=Homo 1.00 1.00 0.00 sapiens GN=RAPGEF3 PE=1 SV=5 SYNP2_HUMAN Synaptopodin‐2 OS=Homo sapiens GN=SYNPO2 PE=1 1.00 1.00 0.00

© 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 SV=2 TAF1L_HUMAN Transcription initiation factor TFIID subunit 1‐like 1.00 1.00 0.00 OS=Homo sapiens GN=TAF1L PE=1 SV=1 CO3A1_HUMAN Collagen alpha‐1(III) chain OS=Homo sapiens 1.00 1.00 0.00 GN=COL3A1 PE=1 SV=4 PECA1_HUMAN Platelet endothelial cell adhesion molecule OS=Homo 1.00 1.00 0.00 sapiens GN=PECAM1 PE=1 SV=1 ECP_HUMAN Eosinophil cationic protein OS=Homo sapiens 1.00 1.00 0.00 GN=RNASE3 PE=1 SV=2 APOC1_HUMAN Apolipoprotein C‐I OS=Homo sapiens GN=APOC1 PE=1 1.00 1.00 0.00 SV=1 KPRP_HUMAN Keratinocyte proline‐rich protein OS=Homo sapiens 1.00 1.00 0.00 GN=KPRP PE=1 SV=1 OPTN_HUMAN Optineurin OS=Homo sapiens GN=OPTN PE=1 SV=1 1.00 1.00 0.00 RRAS2_HUMAN Ras‐related protein R‐Ras2 OS=Homo sapiens 1.00 1.00 0.00 GN=RRAS2 PE=1 SV=1 AEBP1_HUMAN Adipocyte enhancer‐binding protein 1 OS=Homo 1.00 1.00 0.00 sapiens GN=AEBP1 PE=1 SV=1 GP126_HUMAN G‐protein coupled receptor 126 OS=Homo sapiens 1.00 1.00 0.00 GN=GPR126 PE=1 SV=3 SRSIP_HUMAN SRSF2‐interacting protein OS=Homo sapiens 1.00 1.00 0.00 GN=SRSF2IP PE=1 SV=2 HV306_HUMAN Ig heavy chain V‐III region BUT OS=Homo sapiens PE=1 1.00 1.00 0.00 SV=1 CHM2A_HUMAN Charged multivesicular body protein 2a OS=Homo 1.00 1.00 0.00 sapiens GN=CHMP2A PE=1 SV=1 SET1A_HUMAN Histone‐lysine N‐methyltransferase SETD1A OS=Homo 1.00 1.00 0.00 sapiens GN=SETD1A PE=1 SV=3 CCD21_HUMAN Coiled‐coil domain‐containing protein 21 OS=Homo 1.00 1.00 0.00 sapiens GN=CCDC21 PE=1 SV=1 PTAR1_HUMAN Protein prenyltransferase alpha subunit repeat‐ 1.00 1.00 0.00 containing protein 1 OS=Homo sapiens GN=PTAR1 PE=2 SV=2 K2C80_HUMAN Keratin, type II cytoskeletal 80 OS=Homo sapiens 1.00 1.00 0.00 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 GN=KRT80 PE=1 SV=2 CCD24_HUMAN Coiled‐coil domain‐containing protein 24 OS=Homo 1.00 1.00 0.00 sapiens GN=CCDC24 PE=2 SV=1 PZRN4_HUMAN PDZ domain‐containing RING finger protein 4 1.00 1.00 0.00 OS=Homo sapiens GN=PDZRN4 PE=1 SV=3 TTLL7_HUMAN Tubulin polyglutamylase TTLL7 OS=Homo sapiens 1.00 1.00 0.00 GN=TTLL7 PE=2 SV=2 GOPC_HUMAN Golgi‐associated PDZ and coiled‐coil motif‐containing 1.00 1.00 0.00 protein OS=Homo sapiens GN=GOPC PE=1 SV=1 MTMR9_HUMAN Myotubularin‐related protein 9 OS=Homo sapiens 1.00 1.00 0.00 GN=MTMR9 PE=1 SV=1 UN13B_HUMAN Protein unc‐13 homolog B OS=Homo sapiens 1.00 1.00 0.00 GN=UNC13B PE=1 SV=2 TM11D_HUMAN Transmembrane protease serine 11D OS=Homo 1.00 1.00 0.00 sapiens GN=TMPRSS11D PE=1 SV=1 MYO1C_HUMAN Myosin‐Ic OS=Homo sapiens GN=MYO1C PE=1 SV=3 1.00 1.00 0.00 SP4_HUMAN Transcription factor Sp4 OS=Homo sapiens GN=SP4 PE=1 1.00 1.00 0.00 SV=2 FUCO2_HUMAN Plasma alpha‐L‐fucosidase OS=Homo sapiens 1.00 1.00 0.00 GN=FUCA2 PE=1 SV=2 T151B_HUMAN Transmembrane protein 151B OS=Homo sapiens 1.00 1.00 0.00 GN=TMEM151B PE=2 SV=2 ACY1_HUMAN Aminoacylase‐1 OS=Homo sapiens GN=ACY1 PE=1 SV=1 1.00 1.00 0.00 NUCB1_HUMAN Nucleobindin‐1 OS=Homo sapiens GN=NUCB1 PE=1 1.00 1.00 0.00 SV=4 NADC_HUMAN Nicotinate‐nucleotide pyrophosphorylase 1.00 1.00 0.00 [carboxylating] OS=Homo sapiens GN=QPRT PE=1 SV=3 RAB19_HUMAN Ras‐related protein Rab‐19 OS=Homo sapiens 1.00 1.00 0.00 GN=RAB19 PE=2 SV=2 PUR8_HUMAN Adenylosuccinate lyase OS=Homo sapiens GN=ADSL 1.00 1.00 0.00 PE=1 SV=2 TTLL8_HUMAN Protein monoglycylase TTLL8 OS=Homo sapiens 1.00 1.00 0.00 GN=TTLL8 PE=1 SV=3 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 CS010_HUMAN UPF0556 protein C19orf10 OS=Homo sapiens 1.00 1.00 0.00 GN=C19orf10 PE=1 SV=1 ACPL2_HUMAN Acid phosphatase‐like protein 2 OS=Homo sapiens 1.00 1.00 0.00 GN=ACPL2 PE=2 SV=1 ARHGB_HUMAN Rho guanine nucleotide exchange factor 11 OS=Homo 1.00 1.00 0.00 sapiens GN=ARHGEF11 PE=1 SV=1 TMBI1_HUMAN Transmembrane BAX inhibitor motif‐containing 1.00 1.00 0.00 protein 1 OS=Homo sapiens GN=TMBIM1 PE=1 SV=2 FCER2_HUMAN Low affinity immunoglobulin epsilon Fc receptor 1.00 1.00 0.00 OS=Homo sapiens GN=FCER2 PE=1 SV=1 MAP4_HUMAN Microtubule‐associated protein 4 OS=Homo sapiens 1.00 1.00 0.00 GN=MAP4 PE=1 SV=3 SP6_HUMAN Transcription factor Sp6 OS=Homo sapiens GN=SP6 PE=1 1.00 1.00 0.00 SV=1 VNN1_HUMAN Pantetheinase OS=Homo sapiens GN=VNN1 PE=1 SV=2 1.00 1.00 0.00 HXK3_HUMAN Hexokinase‐3 OS=Homo sapiens GN=HK3 PE=1 SV=2 1.00 1.00 0.00 LAMB4_HUMAN Laminin subunit beta‐4 OS=Homo sapiens GN=LAMB4 1.00 1.00 0.00 PE=2 SV=1 M3K3_HUMAN Mitogen‐activated protein kinase kinase kinase 3 1.00 1.00 0.00 OS=Homo sapiens GN=MAP3K3 PE=1 SV=2 OPHN1_HUMAN Oligophrenin‐1 OS=Homo sapiens GN=OPHN1 PE=2 1.00 1.00 0.00 SV=1 BAMBI_HUMAN BMP and activin membrane‐bound inhibitor homolog 1.00 1.00 0.00 OS=Homo sapiens GN=BAMBI PE=1 SV=1 MAGBI_HUMAN Melanoma‐associated antigen B18 OS=Homo sapiens 1.00 1.00 0.00 GN=MAGEB18 PE=1 SV=2 DOT1L_HUMAN Histone‐lysine N‐methyltransferase, H3 lysine‐79 1.00 1.00 0.00 specific OS=Homo sapiens GN=DOT1L PE=1 SV=2 YO011_HUMAN Putative transmembrane protein ENSP00000320207 1.00 1.00 0.00 OS=Homo sapiens PE=5 SV=1 PGP_HUMAN Phosphoglycolate phosphatase OS=Homo sapiens 1.00 1.00 0.00 GN=PGP PE=1 SV=1 LIRA5_HUMAN Leukocyte immunoglobulin‐like receptor subfamily A 1.00 1.00 0.00 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 member 5 OS=Homo sapiens GN=LILRA5 PE=1 SV=1 K2022_HUMAN Uncharacterized protein KIAA2022 OS=Homo sapiens 1.00 1.00 0.00 GN=KIAA2022 PE=2 SV=1 MYO7A_HUMAN Myosin‐VIIa OS=Homo sapiens GN=MYO7A PE=1 1.00 1.00 0.00 SV=1 ERC2_HUMAN ERC protein 2 OS=Homo sapiens GN=ERC2 PE=1 SV=3 1.00 1.00 0.00 UBD_HUMAN Ubiquitin D OS=Homo sapiens GN=UBD PE=1 SV=2 1.00 1.00 0.00 SAMP_HUMAN Serum amyloid P‐component OS=Homo sapiens 1.00 1.00 0.00 GN=APCS PE=1 SV=2 PKHA4_HUMAN Pleckstrin homology domain‐containing family A 1.00 1.00 0.00 member 4 OS=Homo sapiens GN=PLEKHA4 PE=1 SV=2 GTR11_HUMAN Solute carrier family 2, facilitated glucose transporter 1.00 1.00 0.00 member 11 OS=Homo sapiens GN=SLC2A11 PE=2 SV=1 PEDF_HUMAN Pigment epithelium‐derived factor OS=Homo sapiens 1.00 1.00 0.00 GN=SERPINF1 PE=1 SV=3 EYS_HUMAN Protein eyes shut homolog OS=Homo sapiens GN=EYS 1.00 1.00 0.00 PE=1 SV=4 NSUN7_HUMAN Putative methyltransferase NSUN7 OS=Homo sapiens 1.00 1.00 0.00 GN=NSUN7 PE=2 SV=3 NT5D3_HUMAN 5'‐nucleotidase domain‐containing protein 3 1.00 1.00 0.00 OS=Homo sapiens GN=NT5DC3 PE=2 SV=1 SMC4_HUMAN Structural maintenance of chromosomes protein 4 1.00 1.00 0.00 OS=Homo sapiens GN=SMC4 PE=1 SV=2 PD1L2_HUMAN Programmed cell death 1 ligand 2 OS=Homo sapiens 1.00 1.00 0.00 GN=PDCD1LG2 PE=1 SV=2 SNX18_HUMAN Sorting nexin‐18 OS=Homo sapiens GN=SNX18 PE=1 1.00 1.00 0.00 SV=2 PCDH9_HUMAN Protocadherin‐9 OS=Homo sapiens GN=PCDH9 PE=1 1.00 1.00 0.00 SV=2 LHPP_HUMAN Phospholysine phosphohistidine inorganic 1.00 1.00 0.00 pyrophosphate phosphatase OS=Homo sapiens GN=LHPP PE=1 SV=2 PEF1_HUMAN Peflin OS=Homo sapiens GN=PEF1 PE=1 SV=1 1.00 1.00 0.00 CO5A2_HUMAN Collagen alpha‐2(V) chain OS=Homo sapiens 1.00 1.00 0.00 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 GN=COL5A2 PE=1 SV=3 PTER_HUMAN Phosphotriesterase‐related protein OS=Homo sapiens 1.00 1.00 0.00 GN=PTER PE=1 SV=1 PRS35_HUMAN Inactive serine protease 35 OS=Homo sapiens 1.00 1.00 0.00 GN=PRSS35 PE=2 SV=2 UPK1A_HUMAN Uroplakin‐1a OS=Homo sapiens GN=UPK1A PE=2 SV=1 1.00 1.00 0.00 ERIC1_HUMAN Glutamate‐rich protein 1 OS=Homo sapiens GN=ERICH1 1.00 1.00 0.00 PE=1 SV=1 GTR5_HUMAN Solute carrier family 2, facilitated glucose transporter 1.00 1.00 0.00 member 5 OS=Homo sapiens GN=SLC2A5 PE=1 SV=1 OLM2A_HUMAN Olfactomedin‐like protein 2A OS=Homo sapiens 1.00 1.00 0.00 GN=OLFML2A PE=2 SV=1 GLRX5_HUMAN Glutaredoxin‐related protein 5, mitochondrial 1.00 1.00 0.00 OS=Homo sapiens GN=GLRX5 PE=1 SV=2 LGUL_HUMAN Lactoylglutathione lyase OS=Homo sapiens GN=GLO1 1.00 1.00 0.00 PE=1 SV=4 IL16_HUMAN Pro‐interleukin‐16 OS=Homo sapiens GN=IL16 PE=1 SV=4 1.00 1.00 0.00 FHOD3_HUMAN FH1/FH2 domain‐containing protein 3 OS=Homo 1.00 1.00 0.00 sapiens GN=FHOD3 PE=1 SV=2 S38AA_HUMAN Putative sodium‐coupled neutral amino acid 1.00 1.00 0.00 transporter 10 OS=Homo sapiens GN=SLC38A10 PE=1 SV=2 IRF7_HUMAN Interferon regulatory factor 7 OS=Homo sapiens 1.00 1.00 0.00 GN=IRF7 PE=1 SV=2 GNAT1_HUMAN Guanine nucleotide‐binding protein G(t) subunit 1.00 1.00 0.00 alpha‐1 OS=Homo sapiens GN=GNAT1 PE=1 SV=5 HLAG_HUMAN HLA class I histocompatibility antigen, alpha chain G 1.00 1.00 0.00 OS=Homo sapiens GN=HLA‐G PE=1 SV=1 BMPR2_HUMAN Bone morphogenetic protein receptor type‐2 1.00 1.00 0.00 OS=Homo sapiens GN=BMPR2 PE=1 SV=2 SRSF1_HUMAN Serine/arginine‐rich splicing factor 1 OS=Homo sapiens 1.00 1.00 0.00 GN=SRSF1 PE=1 SV=2 KPCD3_HUMAN Serine/threonine‐protein kinase D3 OS=Homo sapiens 1.00 1.00 0.00 GN=PRKD3 PE=1 SV=1 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 ALDOC_HUMAN Fructose‐bisphosphate aldolase C OS=Homo sapiens 1.00 1.00 0.00 GN=ALDOC PE=1 SV=2 MTM1_HUMAN Myotubularin OS=Homo sapiens GN=MTM1 PE=1 1.00 1.00 0.00 SV=2 COL12_HUMAN Collectin‐12 OS=Homo sapiens GN=COLEC12 PE=1 1.00 1.00 0.00 SV=3 CJ093_HUMAN TPR repeat‐containing protein C10orf93 OS=Homo 1.00 1.00 0.00 sapiens GN=C10orf93 PE=2 SV=2 PUS7L_HUMAN Pseudouridylate synthase 7 homolog‐like protein 1.00 1.00 0.00 OS=Homo sapiens GN=PUS7L PE=1 SV=1 CLPT1_HUMAN Cleft lip and palate transmembrane protein 1 1.00 1.00 0.00 OS=Homo sapiens GN=CLPTM1 PE=1 SV=1 PSB2_HUMAN Proteasome subunit beta type‐2 OS=Homo sapiens 1.00 1.00 0.00 GN=PSMB2 PE=1 SV=1 RBM19_HUMAN Probable RNA‐binding protein 19 OS=Homo sapiens 1.00 1.00 0.00 GN=RBM19 PE=1 SV=3 KIF12_HUMAN Kinesin‐like protein KIF12 OS=Homo sapiens GN=KIF12 1.00 1.00 0.00 PE=2 SV=3 CSTN3_HUMAN Calsyntenin‐3 OS=Homo sapiens GN=CLSTN3 PE=1 1.00 1.00 0.00 SV=1 CO9_HUMAN Complement component C9 OS=Homo sapiens GN=C9 1.00 1.00 0.00 PE=1 SV=2 BT3L2_HUMAN Transcription factor BTF3 homolog 2 OS=Homo sapiens 1.00 1.00 0.00 GN=BTF3L2 PE=2 SV=1 ERCC6_HUMAN DNA excision repair protein ERCC‐6 OS=Homo sapiens 1.00 1.00 0.00 GN=ERCC6 PE=1 SV=1 HECW1_HUMAN E3 ubiquitin‐protein ligase HECW1 OS=Homo sapiens 1.00 1.00 0.00 GN=HECW1 PE=1 SV=3 RHG32_HUMAN Rho GTPase‐activating protein 32 OS=Homo sapiens 1.00 1.00 0.00 GN=ARHGAP32 PE=1 SV=1 GOGA4_HUMAN Golgin subfamily A member 4 OS=Homo sapiens 1.00 1.00 0.00 GN=GOLGA4 PE=1 SV=1 INP4B_HUMAN Type II inositol‐3,4‐bisphosphate 4‐phosphatase 1.00 1.00 0.00

© 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 OS=Homo sapiens GN=INPP4B PE=2 SV=4 MGDP1_HUMAN Magnesium‐dependent phosphatase 1 OS=Homo 1.00 1.00 0.00 sapiens GN=MDP1 PE=1 SV=1 DLEC1_HUMAN Deleted in lung and esophageal cancer protein 1 1.00 1.00 0.00 OS=Homo sapiens GN=DLEC1 PE=2 SV=2 CHSTE_HUMAN Carbohydrate sulfotransferase 14 OS=Homo sapiens 1.00 1.00 0.00 GN=CHST14 PE=1 SV=2 ARI4B_HUMAN AT‐rich interactive domain‐containing protein 4B 1.00 1.00 0.00 OS=Homo sapiens GN=ARID4B PE=1 SV=2 PALM_HUMAN Paralemmin OS=Homo sapiens GN=PALM PE=1 SV=2 1.00 1.00 0.00 KCNB1_HUMAN Potassium voltage‐gated channel subfamily B member 1.00 1.00 0.00 1 OS=Homo sapiens GN=KCNB1 PE=1 SV=2 DGKE_HUMAN Diacylglycerol kinase epsilon OS=Homo sapiens 1.00 1.00 0.00 GN=DGKE PE=1 SV=1 CROCC_HUMAN Rootletin OS=Homo sapiens GN=CROCC PE=1 SV=1 1.00 1.00 0.00 MARCS_HUMAN Myristoylated alanine‐rich C‐kinase substrate 1.00 1.00 0.00 OS=Homo sapiens GN=MARCKS PE=1 SV=4 SHD_HUMAN SH2 domain‐containing adapter protein D OS=Homo 1.00 1.00 0.00 sapiens GN=SHD PE=2 SV=1 EPHB3_HUMAN Ephrin type‐B receptor 3 OS=Homo sapiens GN=EPHB3 1.00 1.00 0.00 PE=1 SV=2 CA026_HUMAN Uncharacterized protein C1orf26 OS=Homo sapiens 1.00 1.00 0.00 GN=C1orf26 PE=2 SV=1 CHD7_HUMAN Chromodomain‐helicase‐DNA‐binding protein 7 1.00 1.00 0.00 OS=Homo sapiens GN=CHD7 PE=1 SV=3 FLRT1_HUMAN Leucine‐rich repeat transmembrane protein FLRT1 1.00 1.00 0.00 OS=Homo sapiens GN=FLRT1 PE=1 SV=3 CR1_HUMAN Complement receptor type 1 OS=Homo sapiens GN=CR1 1.00 1.00 0.00 PE=1 SV=3 MATN3_HUMAN Matrilin‐3 OS=Homo sapiens GN=MATN3 PE=1 SV=2 1.00 1.00 0.00 IKBE_HUMAN NF‐kappa‐B inhibitor epsilon OS=Homo sapiens 1.00 1.00 0.00 GN=NFKBIE PE=1 SV=3 NSD2_HUMAN Probable histone‐lysine N‐methyltransferase NSD2 1.00 1.00 0.00 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 OS=Homo sapiens GN=WHSC1 PE=1 SV=1 NMD3B_HUMAN Glutamate [NMDA] receptor subunit 3B OS=Homo 1.00 1.00 0.00 sapiens GN=GRIN3B PE=2 SV=2 U520_HUMAN U5 small nuclear ribonucleoprotein 200 kDa helicase 1.00 1.00 0.00 OS=Homo sapiens GN=SNRNP200 PE=1 SV=2 S39AA_HUMAN Zinc transporter ZIP10 OS=Homo sapiens 1.00 1.00 0.00 GN=SLC39A10 PE=1 SV=2 NCOR2_HUMAN Nuclear receptor corepressor 2 OS=Homo sapiens 1.00 1.00 0.00 GN=NCOR2 PE=1 SV=2 DTL_HUMAN Denticleless protein homolog OS=Homo sapiens GN=DTL 1.00 1.00 0.00 PE=1 SV=3 TTC6_HUMAN Tetratricopeptide repeat protein 6 OS=Homo sapiens 1.00 1.00 0.00 GN=TTC6 PE=2 SV=1 STAB2_HUMAN Stabilin‐2 OS=Homo sapiens GN=STAB2 PE=1 SV=3 1.00 1.00 0.00 GRIA4_HUMAN Glutamate receptor 4 OS=Homo sapiens GN=GRIA4 1.00 1.00 0.00 PE=2 SV=2 ARI5B_HUMAN AT‐rich interactive domain‐containing protein 5B 1.00 1.00 0.00 OS=Homo sapiens GN=ARID5B PE=1 SV=3 TNC18_HUMAN Trinucleotide repeat‐containing gene 18 protein 1.00 1.00 0.00 OS=Homo sapiens GN=TNRC18 PE=1 SV=3 LIRB4_HUMAN Leukocyte immunoglobulin‐like receptor subfamily B 1.00 1.00 0.00 member 4 OS=Homo sapiens GN=LILRB4 PE=1 SV=2 ROCK1_HUMAN Rho‐associated protein kinase 1 OS=Homo sapiens 1.00 1.00 0.00 GN=ROCK1 PE=1 SV=1 TITIN_HUMAN Titin OS=Homo sapiens GN=TTN PE=1 SV=2 1.00 1.00 0.00 TMPS2_HUMAN Transmembrane protease serine 2 OS=Homo sapiens 1.00 1.00 0.00 GN=TMPRSS2 PE=1 SV=3 K1609_HUMAN TLD domain‐containing protein KIAA1609 OS=Homo 1.00 1.00 0.00 sapiens GN=KIAA1609 PE=1 SV=2 PANK1_HUMAN Pantothenate kinase 1 OS=Homo sapiens GN=PANK1 1.00 1.00 0.00 PE=1 SV=2 TMTC4_HUMAN Transmembrane and TPR repeat‐containing protein 4 1.00 1.00 0.00 OS=Homo sapiens GN=TMTC4 PE=1 SV=2 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 PARVA_HUMAN Alpha‐parvin OS=Homo sapiens GN=PARVA PE=1 SV=1 1.00 1.00 0.00 ST14_HUMAN Suppressor of tumorigenicity 14 protein OS=Homo 1.00 1.00 0.00 sapiens GN=ST14 PE=1 SV=2 BPI_HUMAN Bactericidal permeability‐increasing protein OS=Homo 1.00 1.00 0.00 sapiens GN=BPI PE=1 SV=4 CJ046_HUMAN Uncharacterized protein C10orf46 OS=Homo sapiens 1.00 1.00 0.00 GN=C10orf46 PE=2 SV=1 PAK3_HUMAN Serine/threonine‐protein kinase PAK 3 OS=Homo 1.00 1.00 0.00 sapiens GN=PAK3 PE=1 SV=2 MRM1_HUMAN rRNA methyltransferase 1, mitochondrial OS=Homo 1.00 1.00 0.00 sapiens GN=MRM1 PE=1 SV=1 ZBT8A_HUMAN Zinc finger and BTB domain‐containing protein 8A 1.00 1.00 0.00 OS=Homo sapiens GN=ZBTB8A PE=1 SV=2 SYNE2_HUMAN Nesprin‐2 OS=Homo sapiens GN=SYNE2 PE=1 SV=3 1.00 1.00 0.00 NXF1_HUMAN Nuclear RNA export factor 1 OS=Homo sapiens 1.00 1.00 0.00 GN=NXF1 PE=1 SV=1 GIMA8_HUMAN GTPase IMAP family member 8 OS=Homo sapiens 1.00 1.00 0.00 GN=GIMAP8 PE=1 SV=2 ERBB3_HUMAN Receptor tyrosine‐protein kinase erbB‐3 OS=Homo 1.00 1.00 0.00 sapiens GN=ERBB3 PE=1 SV=1 ADML_HUMAN ADM OS=Homo sapiens GN=ADM PE=1 SV=1 1.00 1.00 0.00 RPC1_HUMAN DNA‐directed RNA polymerase III subunit RPC1 1.00 1.00 0.00 OS=Homo sapiens GN=POLR3A PE=1 SV=2 LKHA4_HUMAN Leukotriene A‐4 hydrolase OS=Homo sapiens 1.00 1.00 0.00 GN=LTA4H PE=1 SV=2 CB055_HUMAN Uncharacterized protein C2orf55 OS=Homo sapiens 1.00 1.00 0.00 GN=C2orf55 PE=1 SV=3 DOK3_HUMAN Docking protein 3 OS=Homo sapiens GN=DOK3 PE=1 1.00 1.00 0.00 SV=2 NTNG1_HUMAN Netrin‐G1 OS=Homo sapiens GN=NTNG1 PE=1 SV=3 1.00 1.00 0.00 ACL7A_HUMAN Actin‐like protein 7A OS=Homo sapiens GN=ACTL7A 1.00 1.00 0.00 PE=2 SV=1 GDPD5_HUMAN Glycerophosphodiester phosphodiesterase domain‐ 1.00 1.00 0.00 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 containing protein 5 OS=Homo sapiens GN=GDPD5 PE=2 SV=2 HCN4_HUMAN Potassium/sodium hyperpolarization‐activated cyclic 1.00 1.00 0.00 nucleotide‐gated channel 4 OS=Homo sapiens GN=HCN4 PE=1 SV=1 PTHR_HUMAN Parathyroid hormone‐related protein OS=Homo sapiens 1.00 1.00 0.00 GN=PTHLH PE=1 SV=1 FRPD1_HUMAN FERM and PDZ domain‐containing protein 1 OS=Homo 1.00 1.00 0.00 sapiens GN=FRMPD1 PE=1 SV=1 ZFHX4_HUMAN Zinc finger homeobox protein 4 OS=Homo sapiens 1.00 1.00 0.00 GN=ZFHX4 PE=1 SV=1 INT3_HUMAN Integrator complex subunit 3 OS=Homo sapiens 1.00 1.00 0.00 GN=INTS3 PE=1 SV=1 NQO2_HUMAN Ribosyldihydronicotinamide dehydrogenase [quinone] 1.00 1.00 0.00 OS=Homo sapiens GN=NQO2 PE=1 SV=4 CI140_HUMAN Protein C9orf140 OS=Homo sapiens GN=C9orf140 PE=2 1.00 1.00 0.00 SV=2 AFG32_HUMAN AFG3‐like protein 2 OS=Homo sapiens GN=AFG3L2 1.00 1.00 0.00 PE=1 SV=2 SAM50_HUMAN Sorting and assembly machinery component 50 1.00 1.00 0.00 homolog OS=Homo sapiens GN=SAMM50 PE=1 SV=3 CPLX1_HUMAN Complexin‐1 OS=Homo sapiens GN=CPLX1 PE=1 SV=1 1.00 1.00 0.00 PTX3_HUMAN Pentraxin‐related protein PTX3 OS=Homo sapiens 1.00 1.00 0.00 GN=PTX3 PE=1 SV=3 DC1L2_HUMAN Cytoplasmic dynein 1 light intermediate chain 2 1.00 1.00 0.00 OS=Homo sapiens GN=DYNC1LI2 PE=1 SV=1 TOP2A_HUMAN DNA topoisomerase 2‐alpha OS=Homo sapiens 1.00 1.00 0.00 GN=TOP2A PE=1 SV=3 RYR3_HUMAN Ryanodine receptor 3 OS=Homo sapiens GN=RYR3 PE=1 1.00 1.00 0.00 SV=2 KGP1_HUMAN cGMP‐dependent protein kinase 1 OS=Homo sapiens 1.00 1.00 0.00 GN=PRKG1 PE=1 SV=3 THAP2_HUMAN THAP domain‐containing protein 2 OS=Homo sapiens 1.00 1.00 0.00 GN=THAP2 PE=1 SV=1 CD5L_HUMAN CD5 antigen‐like OS=Homo sapiens GN=CD5L PE=1 SV=1 1.00 1.00 0.00 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 RA1L3_HUMAN Putative heterogeneous nuclear ribonucleoprotein A1‐ 1.00 1.00 0.00 like 3 OS=Homo sapiens GN=HNRPA1L3 PE=5 SV=1 PDE4C_HUMAN cAMP‐specific 3',5'‐cyclic phosphodiesterase 4C 1.00 1.00 0.00 OS=Homo sapiens GN=PDE4C PE=1 SV=2 FBLN3_HUMAN EGF‐containing fibulin‐like extracellular matrix protein 1.00 1.00 0.00 1 OS=Homo sapiens GN=EFEMP1 PE=1 SV=2 ESTD_HUMAN S‐formylglutathione hydrolase OS=Homo sapiens 1.00 1.00 0.00 GN=ESD PE=1 SV=2 MBLC2_HUMAN Metallo‐beta‐lactamase domain‐containing protein 2 1.00 1.00 0.00 OS=Homo sapiens GN=MBLAC2 PE=1 SV=3 PEBP4_HUMAN Phosphatidylethanolamine‐binding protein 4 1.00 1.00 0.00 OS=Homo sapiens GN=PEBP4 PE=1 SV=3 S22AK_HUMAN Solute carrier family 22 member 20 OS=Homo sapiens 1.00 1.00 0.00 GN=SLC22A20 PE=2 SV=1 SPDE3_HUMAN Speedy protein E3 OS=Homo sapiens GN=SPDYE3 PE=2 1.00 1.00 0.00 SV=2 ASPP2_HUMAN Apoptosis‐stimulating of p53 protein 2 OS=Homo 1.00 1.00 0.00 sapiens GN=TP53BP2 PE=1 SV=2 ERBB4_HUMAN Receptor tyrosine‐protein kinase erbB‐4 OS=Homo 1.00 1.00 0.00 sapiens GN=ERBB4 PE=1 SV=1 IF2B3_HUMAN Insulin‐like growth factor 2 mRNA‐binding protein 3 1.00 1.00 0.00 OS=Homo sapiens GN=IGF2BP3 PE=1 SV=2 HNRPL_HUMAN Heterogeneous nuclear ribonucleoprotein L OS=Homo 1.00 1.00 0.00 sapiens GN=HNRNPL PE=1 SV=2 FUS_HUMAN RNA‐binding protein FUS OS=Homo sapiens GN=FUS 1.00 1.00 0.00 PE=1 SV=1 VPP3_HUMAN V‐type proton ATPase 116 kDa subunit a isoform 3 1.00 1.00 0.00 OS=Homo sapiens GN=TCIRG1 PE=1 SV=3 SETMR_HUMAN Histone‐lysine N‐methyltransferase SETMAR 1.00 1.00 0.00 OS=Homo sapiens GN=SETMAR PE=1 SV=1 FIL1L_HUMAN Filamin A‐interacting protein 1‐like OS=Homo sapiens 1.00 1.00 0.00 GN=FILIP1L PE=1 SV=2 JKIP3_HUMAN Janus kinase and microtubule‐interacting protein 3 1.00 1.00 0.00

© 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 OS=Homo sapiens GN=JAKMIP3 PE=2 SV=2 CD27_HUMAN CD27 antigen OS=Homo sapiens GN=CD27 PE=1 SV=2 1.00 1.00 0.00 ANK3_HUMAN Ankyrin‐3 OS=Homo sapiens GN=ANK3 PE=1 SV=3 1.00 1.00 0.00 CGT_HUMAN 2‐hydroxyacylsphingosine 1‐beta‐galactosyltransferase 1.00 1.00 0.00 OS=Homo sapiens GN=UGT8 PE=2 SV=2 COHA1_HUMAN Collagen alpha‐1(XVII) chain OS=Homo sapiens 1.00 1.00 0.00 GN=COL17A1 PE=1 SV=3 ALDH2_HUMAN Aldehyde dehydrogenase, mitochondrial OS=Homo 1.00 1.00 0.00 sapiens GN=ALDH2 PE=1 SV=2 DSPP_HUMAN Dentin sialophosphoprotein OS=Homo sapiens 1.00 1.00 0.00 GN=DSPP PE=1 SV=2 MUC2_HUMAN Mucin‐2 OS=Homo sapiens GN=MUC2 PE=1 SV=2 1.00 1.00 0.00 CYFP2_HUMAN Cytoplasmic FMR1‐interacting protein 2 OS=Homo 1.00 1.00 0.00 sapiens GN=CYFIP2 PE=1 SV=2 6PGD_HUMAN 6‐phosphogluconate dehydrogenase, decarboxylating 1.00 1.00 0.00 OS=Homo sapiens GN=PGD PE=1 SV=3 KLK5_HUMAN Kallikrein‐5 OS=Homo sapiens GN=KLK5 PE=1 SV=2 1.00 1.00 0.00 SYBU_HUMAN Syntabulin OS=Homo sapiens GN=SYBU PE=1 SV=2 1.00 1.00 0.00 CDHR5_HUMAN Cadherin‐related family member 5 OS=Homo sapiens 1.00 1.00 0.00 GN=CDHR5 PE=1 SV=3 ACOX3_HUMAN Peroxisomal acyl‐coenzyme A oxidase 3 OS=Homo 1.00 1.00 0.00 sapiens GN=ACOX3 PE=1 SV=2 LRRC7_HUMAN Leucine‐rich repeat‐containing protein 7 OS=Homo 1.00 1.00 0.00 sapiens GN=LRRC7 PE=1 SV=1 DLG5_HUMAN Disks large homolog 5 OS=Homo sapiens GN=DLG5 1.00 1.00 0.00 PE=1 SV=4 NMDE1_HUMAN Glutamate [NMDA] receptor subunit epsilon‐1 1.00 1.00 0.00 OS=Homo sapiens GN=GRIN2A PE=1 SV=1 HEXA_HUMAN Beta‐hexosaminidase subunit alpha OS=Homo sapiens 1.00 1.00 0.00 GN=HEXA PE=1 SV=2 TFE3_HUMAN Transcription factor E3 OS=Homo sapiens GN=TFE3 PE=1 1.00 1.00 0.00 SV=4 KLHL5_HUMAN Kelch‐like protein 5 OS=Homo sapiens GN=KLHL5 PE=2 1.00 1.00 0.00 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 SV=3 TM149_HUMAN Transmembrane protein 149 OS=Homo sapiens 1.00 1.00 0.00 GN=TMEM149 PE=2 SV=1 TBX18_HUMAN T‐box transcription factor TBX18 OS=Homo sapiens 1.00 1.00 0.00 GN=TBX18 PE=2 SV=3 VIP2_HUMAN Inositol hexakisphosphate and diphosphoinositol‐ 1.00 1.00 0.00 pentakisphosphate kinase 2 OS=Homo sapiens GN=PPIP5K2 PE=1 SV=3 RB6I2_HUMAN ELKS/Rab6‐interacting/CAST family member 1 1.00 1.00 0.00 OS=Homo sapiens GN=ERC1 PE=1 SV=1 PKH4B_HUMAN Pleckstrin homology domain‐containing family G 1.00 1.00 0.00 member 4B OS=Homo sapiens GN=PLEKHG4B PE=2 SV=4 SNP47_HUMAN Synaptosomal‐associated protein 47 OS=Homo 1.00 1.00 0.00 sapiens GN=SNAP47 PE=2 SV=3 CN16B_HUMAN Uncharacterized protein C14orf166B OS=Homo 1.00 1.00 0.00 sapiens GN=C14orf166B PE=2 SV=2 MKS1_HUMAN Meckel syndrome type 1 protein OS=Homo sapiens 1.00 1.00 0.00 GN=MKS1 PE=1 SV=2 O52A1_HUMAN Olfactory receptor 52A1 OS=Homo sapiens 1.00 1.00 0.00 GN=OR52A1 PE=2 SV=2 C163B_HUMAN Scavenger receptor cysteine‐rich type 1 protein M160 1.00 1.00 0.00 OS=Homo sapiens GN=CD163L1 PE=1 SV=2 CEP72_HUMAN Centrosomal protein of 72 kDa OS=Homo sapiens 1.00 1.00 0.00 GN=CEP72 PE=1 SV=2 NACC2_HUMAN Nucleus accumbens‐associated protein 2 OS=Homo 1.00 1.00 0.00 sapiens GN=NACC2 PE=2 SV=1 BCAR3_HUMAN Breast cancer anti‐estrogen resistance protein 3 1.00 1.00 0.00 OS=Homo sapiens GN=BCAR3 PE=1 SV=1 GPC1_HUMAN Glypican‐1 OS=Homo sapiens GN=GPC1 PE=1 SV=2 1.00 1.00 0.00 NDUS1_HUMAN NADH‐ubiquinone oxidoreductase 75 kDa subunit, 1.00 1.00 0.00 mitochondrial OS=Homo sapiens GN=NDUFS1 PE=1 SV=3 SLK_HUMAN STE20‐like serine/threonine‐protein kinase OS=Homo 1.00 1.00 0.00 sapiens GN=SLK PE=1 SV=1 EHD4_HUMAN EH domain‐containing protein 4 OS=Homo sapiens 1.00 1.00 0.00 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 GN=EHD4 PE=1 SV=1 PPN_HUMAN Papilin OS=Homo sapiens GN=PAPLN PE=2 SV=4 1.00 1.00 0.00 BIG1_HUMAN Brefeldin A‐inhibited guanine nucleotide‐exchange 1.00 1.00 0.00 protein 1 OS=Homo sapiens GN=ARFGEF1 PE=1 SV=2 CD180_HUMAN CD180 antigen OS=Homo sapiens GN=CD180 PE=1 1.00 1.00 0.00 SV=2 WFDC2_HUMAN WAP four‐disulfide core domain protein 2 OS=Homo 1.00 1.00 0.00 sapiens GN=WFDC2 PE=1 SV=2 RM22_HUMAN 39S ribosomal protein L22, mitochondrial OS=Homo 1.00 1.00 0.00 sapiens GN=MRPL22 PE=1 SV=1 TSN8_HUMAN Tetraspanin‐8 OS=Homo sapiens GN=TSPAN8 PE=1 1.00 1.00 0.00 SV=1 KATL1_HUMAN Katanin p60 ATPase‐containing subunit A‐like 1 1.00 1.00 0.00 OS=Homo sapiens GN=KATNAL1 PE=2 SV=1 ZN879_HUMAN Zinc finger protein 879 OS=Homo sapiens GN=ZNF879 1.00 1.00 0.00 PE=2 SV=2 S39A4_HUMAN Zinc transporter ZIP4 OS=Homo sapiens GN=SLC39A4 1.00 1.00 0.00 PE=1 SV=3 DYH7_HUMAN Dynein heavy chain 7, axonemal OS=Homo sapiens 1.00 1.00 0.00 GN=DNAH7 PE=1 SV=2 AL9A1_HUMAN 4‐trimethylaminobutyraldehyde dehydrogenase 1.00 1.00 0.00 OS=Homo sapiens GN=ALDH9A1 PE=1 SV=3 BBS1_HUMAN Bardet‐Biedl syndrome 1 protein OS=Homo sapiens 1.00 1.00 0.00 GN=BBS1 PE=1 SV=1 GSCR1_HUMAN Glioma tumor suppressor candidate region gene 1 1.00 1.00 0.00 protein OS=Homo sapiens GN=GLTSCR1 PE=1 SV=2 ARGAL_HUMAN Rho guanine nucleotide exchange factor 10‐like 1.00 1.00 0.00 protein OS=Homo sapiens GN=ARHGEF10L PE=1 SV=2 C11B2_HUMAN Cytochrome P450 11B2, mitochondrial OS=Homo 1.00 1.00 0.00 sapiens GN=CYP11B2 PE=1 SV=3 JKIP1_HUMAN Janus kinase and microtubule‐interacting protein 1 1.00 1.00 0.00 OS=Homo sapiens GN=JAKMIP1 PE=1 SV=1 SOST_HUMAN Sclerostin OS=Homo sapiens GN=SOST PE=1 SV=1 1.00 1.00 0.00 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 ARAP1_HUMAN Arf‐GAP with Rho‐GAP domain, ANK repeat and PH 1.00 1.00 0.00 domain‐containing protein 1 OS=Homo sapiens GN=ARAP1 PE=1 SV=3 FSHR_HUMAN Follicle‐stimulating hormone receptor OS=Homo 1.00 1.00 0.00 sapiens GN=FSHR PE=1 SV=3 CAC1G_HUMAN Voltage‐dependent T‐type calcium channel subunit 1.00 1.00 0.00 alpha‐1G OS=Homo sapiens GN=CACNA1G PE=2 SV=3 HUTH_HUMAN Histidine ammonia‐lyase OS=Homo sapiens GN=HAL 1.00 1.00 0.00 PE=1 SV=1 NU6M_HUMAN NADH‐ubiquinone oxidoreductase chain 6 OS=Homo 1.00 1.00 0.00 sapiens GN=MT‐ND6 PE=1 SV=2 GGEE1_HUMAN G antigen family E member 1 OS=Homo sapiens 1.00 1.00 0.00 GN=PAGE5 PE=2 SV=2 STIM1_HUMAN Stromal interaction molecule 1 OS=Homo sapiens 1.00 1.00 0.00 GN=STIM1 PE=1 SV=3 ZNF8_HUMAN Zinc finger protein 8 OS=Homo sapiens GN=ZNF8 PE=1 1.00 1.00 0.00 SV=2 BCS1_HUMAN Mitochondrial chaperone BCS1 OS=Homo sapiens 1.00 1.00 0.00 GN=BCS1L PE=1 SV=1 PKHG3_HUMAN Pleckstrin homology domain‐containing family G 1.00 1.00 0.00 member 3 OS=Homo sapiens GN=PLEKHG3 PE=1 SV=1 SORC2_HUMAN VPS10 domain‐containing receptor SorCS2 OS=Homo 1.00 1.00 0.00 sapiens GN=SORCS2 PE=1 SV=3 AQR_HUMAN Intron‐binding protein aquarius OS=Homo sapiens 1.00 1.00 0.00 GN=AQR PE=1 SV=4 IF4G1_HUMAN Eukaryotic translation initiation factor 4 gamma 1 1.00 1.00 0.00 OS=Homo sapiens GN=EIF4G1 PE=1 SV=4 ZN704_HUMAN Zinc finger protein 704 OS=Homo sapiens GN=ZNF704 1.00 1.00 0.00 PE=2 SV=1 ERI3_HUMAN ERI1 exoribonuclease 3 OS=Homo sapiens GN=ERI3 PE=1 1.00 1.00 0.00 SV=2 RAB5A_HUMAN Ras‐related protein Rab‐5A OS=Homo sapiens 1.00 1.00 0.00 GN=RAB5A PE=1 SV=2 TGFR2_HUMAN TGF‐beta receptor type‐2 OS=Homo sapiens 1.00 1.00 0.00

© 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 GN=TGFBR2 PE=1 SV=2 NSF1C_HUMAN NSFL1 cofactor p47 OS=Homo sapiens GN=NSFL1C 1.00 1.00 0.00 PE=1 SV=2 K0649_HUMAN Protein KIAA0649 OS=Homo sapiens GN=KIAA0649 1.00 1.00 0.00 PE=1 SV=1 CAH3_HUMAN Carbonic anhydrase 3 OS=Homo sapiens GN=CA3 PE=1 1.00 1.00 0.00 SV=3 THEG_HUMAN Testicular haploid expressed gene protein OS=Homo 1.00 1.00 0.00 sapiens GN=THEG PE=1 SV=1 CO6_HUMAN Complement component C6 OS=Homo sapiens GN=C6 1.00 1.00 0.00 PE=1 SV=3 NAV3_HUMAN Neuron navigator 3 OS=Homo sapiens GN=NAV3 PE=1 1.00 1.00 0.00 SV=2 TEP1_HUMAN Telomerase protein component 1 OS=Homo sapiens 1.00 1.00 0.00 GN=TEP1 PE=1 SV=2 MVP_HUMAN Major vault protein OS=Homo sapiens GN=MVP PE=1 1.00 1.00 0.00 SV=4 AP1M1_HUMAN AP‐1 complex subunit mu‐1 OS=Homo sapiens 1.00 1.00 0.00 GN=AP1M1 PE=1 SV=3 KCNQ4_HUMAN Potassium voltage‐gated channel subfamily KQT 1.00 1.00 0.00 member 4 OS=Homo sapiens GN=KCNQ4 PE=1 SV=2 SNIP1_HUMAN Smad nuclear‐interacting protein 1 OS=Homo sapiens 1.00 1.00 0.00 GN=SNIP1 PE=1 SV=1 CK5P1_HUMAN CDK5 regulatory subunit‐associated protein 1 1.00 1.00 0.00 OS=Homo sapiens GN=CDK5RAP1 PE=1 SV=2 SP16H_HUMAN FACT complex subunit SPT16 OS=Homo sapiens 1.00 1.00 0.00 GN=SUPT16H PE=1 SV=1 CAB39_HUMAN Calcium‐binding protein 39 OS=Homo sapiens 1.00 1.00 0.00 GN=CAB39 PE=1 SV=1 RBM28_HUMAN RNA‐binding protein 28 OS=Homo sapiens 1.00 1.00 0.00 GN=RBM28 PE=1 SV=3 ENTP1_HUMAN Ectonucleoside triphosphate diphosphohydrolase 1 1.00 1.00 0.00 OS=Homo sapiens GN=ENTPD1 PE=1 SV=1

© 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 PLXA4_HUMAN Plexin‐A4 OS=Homo sapiens GN=PLXNA4 PE=1 SV=4 1.00 1.00 0.00 SNPC1_HUMAN snRNA‐activating protein complex subunit 1 OS=Homo 1.00 1.00 0.00 sapiens GN=SNAPC1 PE=1 SV=1 CCD18_HUMAN Coiled‐coil domain‐containing protein 18 OS=Homo 1.00 1.00 0.00 sapiens GN=CCDC18 PE=1 SV=1 PROF3_HUMAN Profilin‐3 OS=Homo sapiens GN=PFN3 PE=2 SV=1 1.00 1.00 0.00 P66A_HUMAN Transcriptional repressor p66‐alpha OS=Homo sapiens 1.00 1.00 0.00 GN=GATAD2A PE=1 SV=1 MBP_HUMAN Myelin basic protein OS=Homo sapiens GN=MBP PE=1 1.00 1.00 0.00 SV=3 PRDX5_HUMAN Peroxiredoxin‐5, mitochondrial OS=Homo sapiens 1.00 1.00 0.00 GN=PRDX5 PE=1 SV=3 HPS3_HUMAN Hermansky‐Pudlak syndrome 3 protein OS=Homo 1.00 1.00 0.00 sapiens GN=HPS3 PE=1 SV=1 CA106_HUMAN Uncharacterized protein C1orf106 OS=Homo sapiens 1.00 1.00 0.00 GN=C1orf106 PE=2 SV=1 TOR3A_HUMAN Torsin‐3A OS=Homo sapiens GN=TOR3A PE=1 SV=1 1.00 1.00 0.00 DAPK3_HUMAN Death‐associated protein kinase 3 OS=Homo sapiens 1.00 1.00 0.00 GN=DAPK3 PE=1 SV=1 AGAP2_HUMAN Arf‐GAP with GTPase, ANK repeat and PH domain‐ 1.00 1.00 0.00 containing protein 2 OS=Homo sapiens GN=AGAP2 PE=1 SV=2 RARG_HUMAN Retinoic acid receptor gamma OS=Homo sapiens 1.00 1.00 0.00 GN=RARG PE=1 SV=1 ZN592_HUMAN Zinc finger protein 592 OS=Homo sapiens GN=ZNF592 1.00 1.00 0.00 PE=1 SV=2 OLM2B_HUMAN Olfactomedin‐like protein 2B OS=Homo sapiens 1.00 1.00 0.00 GN=OLFML2B PE=2 SV=2 GPR12_HUMAN G‐protein coupled receptor 12 OS=Homo sapiens 1.00 1.00 0.00 GN=GPR12 PE=1 SV=1 SE6L2_HUMAN Seizure 6‐like protein 2 OS=Homo sapiens GN=SEZ6L2 1.00 1.00 0.00 PE=1 SV=1 CTCFL_HUMAN Transcriptional repressor CTCFL OS=Homo sapiens 1.00 1.00 0.00 GN=CTCFL PE=1 SV=1 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 AATM_HUMAN Aspartate aminotransferase, mitochondrial OS=Homo 1.00 1.00 0.00 sapiens GN=GOT2 PE=1 SV=3 TRAD1_HUMAN TRAF‐type zinc finger domain‐containing protein 1 1.00 1.00 0.00 OS=Homo sapiens GN=TRAFD1 PE=1 SV=1 MIA3_HUMAN Melanoma inhibitory activity protein 3 OS=Homo 1.00 1.00 0.00 sapiens GN=MIA3 PE=1 SV=1 MILK1_HUMAN MICAL‐like protein 1 OS=Homo sapiens GN=MICALL1 1.00 1.00 0.00 PE=1 SV=2 SCAP_HUMAN Sterol regulatory element‐binding protein cleavage‐ 1.00 1.00 0.00 activating protein OS=Homo sapiens GN=SCAP PE=1 SV=4 DAF_HUMAN Complement decay‐accelerating factor OS=Homo 1.00 1.00 0.00 sapiens GN=CD55 PE=1 SV=4 NCOR1_HUMAN Nuclear receptor corepressor 1 OS=Homo sapiens 1.00 1.00 0.00 GN=NCOR1 PE=1 SV=2 FABPH_HUMAN Fatty acid‐binding protein, heart OS=Homo sapiens 1.00 1.00 0.00 GN=FABP3 PE=1 SV=4 RAB20_HUMAN Ras‐related protein Rab‐20 OS=Homo sapiens 1.00 1.00 0.00 GN=RAB20 PE=1 SV=1 ST2B1_HUMAN Sulfotransferase family cytosolic 2B member 1 1.00 1.00 0.00 OS=Homo sapiens GN=SULT2B1 PE=1 SV=2 PAR3L_HUMAN Partitioning defective 3 homolog B OS=Homo sapiens 1.00 1.00 0.00 GN=PARD3B PE=1 SV=2 SAM9L_HUMAN Sterile alpha motif domain‐containing protein 9‐like 1.00 1.00 0.00 OS=Homo sapiens GN=SAMD9L PE=1 SV=2 VSIG8_HUMAN V‐set and immunoglobulin domain‐containing protein 1.00 1.00 0.00 8 OS=Homo sapiens GN=VSIG8 PE=1 SV=1 MK15_HUMAN Mitogen‐activated protein kinase 15 OS=Homo sapiens 1.00 1.00 0.00 GN=MAPK15 PE=1 SV=1 LV001_HUMAN Ig lambda chain V region 4A OS=Homo sapiens PE=4 1.00 1.00 0.00 SV=1 CAH4_HUMAN Carbonic anhydrase 4 OS=Homo sapiens GN=CA4 PE=1 1.00 1.00 0.00 SV=2 ZN732_HUMAN Zinc finger protein 732 OS=Homo sapiens GN=ZNF732 1.00 1.00 0.00

© 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 PE=2 SV=1 NPHP3_HUMAN Nephrocystin‐3 OS=Homo sapiens GN=NPHP3 PE=1 1.00 1.00 0.00 SV=1 HACL1_HUMAN 2‐hydroxyacyl‐CoA lyase 1 OS=Homo sapiens 1.00 1.00 0.00 GN=HACL1 PE=1 SV=2 PDCD1_HUMAN Programmed cell death protein 1 OS=Homo sapiens 1.00 1.00 0.00 GN=PDCD1 PE=2 SV=3 SYCC_HUMAN Cysteinyl‐tRNA synthetase, cytoplasmic OS=Homo 1.00 1.00 0.00 sapiens GN=CARS PE=1 SV=3 VATL_HUMAN V‐type proton ATPase 16 kDa proteolipid subunit 1.00 1.00 0.00 OS=Homo sapiens GN=ATP6V0C PE=1 SV=1 CDD_HUMAN Cytidine deaminase OS=Homo sapiens GN=CDA PE=1 1.00 1.00 0.00 SV=2 CEAM7_HUMAN Carcinoembryonic antigen‐related cell adhesion 1.00 1.00 0.00 molecule 7 OS=Homo sapiens GN=CEACAM7 PE=1 SV=1 LRC28_HUMAN Leucine‐rich repeat‐containing protein 28 OS=Homo 1.00 1.00 0.00 sapiens GN=LRRC28 PE=2 SV=1 DUS10_HUMAN Dual specificity protein phosphatase 10 OS=Homo 1.00 1.00 0.00 sapiens GN=DUSP10 PE=1 SV=1 PYGM_HUMAN Glycogen phosphorylase, muscle form OS=Homo 1.00 1.00 0.00 sapiens GN=PYGM PE=1 SV=6 PLAG1_HUMAN Zinc finger protein PLAG1 OS=Homo sapiens 1.00 1.00 0.00 GN=PLAG1 PE=1 SV=1 PROD_HUMAN Proline dehydrogenase, mitochondrial OS=Homo 1.00 1.00 0.00 sapiens GN=PRODH PE=1 SV=2 SKA3_HUMAN Spindle and kinetochore‐associated protein 3 OS=Homo 1.00 1.00 0.00 sapiens GN=SKA3 PE=1 SV=2 PPE2_HUMAN Serine/threonine‐protein phosphatase with EF‐hands 2 1.00 1.00 0.00 OS=Homo sapiens GN=PPEF2 PE=2 SV=2 IRF6_HUMAN Interferon regulatory factor 6 OS=Homo sapiens 1.00 1.00 0.00 GN=IRF6 PE=1 SV=1 KIF5C_HUMAN Kinesin heavy chain isoform 5C OS=Homo sapiens 1.00 1.00 0.00 GN=KIF5C PE=1 SV=1

© 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 RALA_HUMAN Ras‐related protein Ral‐A OS=Homo sapiens GN=RALA 1.00 1.00 0.00 PE=1 SV=1 CHD2_HUMAN Chromodomain‐helicase‐DNA‐binding protein 2 1.00 1.00 0.00 OS=Homo sapiens GN=CHD2 PE=1 SV=2 LMO7_HUMAN LIM domain only protein 7 OS=Homo sapiens 1.00 1.00 0.00 GN=LMO7 PE=1 SV=3 TBCE_HUMAN Tubulin‐specific chaperone E OS=Homo sapiens 1.00 1.00 0.00 GN=TBCE PE=1 SV=1 AGAL_HUMAN Alpha‐galactosidase A OS=Homo sapiens GN=GLA PE=1 1.00 1.00 0.00 SV=1 CT007_HUMAN Probable methyltransferase C20orf7, mitochondrial 1.00 1.00 0.00 OS=Homo sapiens GN=C20orf7 PE=1 SV=1 COBA2_HUMAN Collagen alpha‐2(XI) chain OS=Homo sapiens 1.00 1.00 0.00 GN=COL11A2 PE=1 SV=4 TNR12_HUMAN Tumor necrosis factor receptor superfamily member 1.00 1.00 0.00 12A OS=Homo sapiens GN=TNFRSF12A PE=1 SV=1 SEM3F_HUMAN Semaphorin‐3F OS=Homo sapiens GN=SEMA3F PE=2 1.00 1.00 0.00 SV=2 SMCA4_HUMAN Transcription activator BRG1 OS=Homo sapiens 1.00 1.00 0.00 GN=SMARCA4 PE=1 SV=2 FKS43_HUMAN Putative FERM domain‐containing protein FKSG43 1.00 1.00 0.00 OS=Homo sapiens GN=FKSG43 PE=5 SV=2 XKR9_HUMAN XK‐related protein 9 OS=Homo sapiens GN=XKR9 PE=2 1.00 1.00 0.00 SV=1 SNW1_HUMAN SNW domain‐containing protein 1 OS=Homo sapiens 1.00 1.00 0.00 GN=SNW1 PE=1 SV=1 CANT1_HUMAN Soluble calcium‐activated nucleotidase 1 OS=Homo 1.00 1.00 0.00 sapiens GN=CANT1 PE=1 SV=1 ZN33A_HUMAN Zinc finger protein 33A OS=Homo sapiens GN=ZNF33A 1.00 1.00 0.00 PE=1 SV=3 CAN7_HUMAN Calpain‐7 OS=Homo sapiens GN=CAPN7 PE=1 SV=1 1.00 1.00 0.00 GRSF1_HUMAN G‐rich sequence factor 1 OS=Homo sapiens GN=GRSF1 1.00 1.00 0.00 PE=1 SV=3

© 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 AKAP3_HUMAN A‐kinase anchor protein 3 OS=Homo sapiens 1.00 1.00 0.00 GN=AKAP3 PE=1 SV=2 ASXL2_HUMAN Putative Polycomb group protein ASXL2 OS=Homo 1.00 1.00 0.00 sapiens GN=ASXL2 PE=1 SV=1 MD2L2_HUMAN Mitotic spindle assembly checkpoint protein MAD2B 1.00 1.00 0.00 OS=Homo sapiens GN=MAD2L2 PE=1 SV=2 TCOF_HUMAN Treacle protein OS=Homo sapiens GN=TCOF1 PE=1 1.00 1.00 0.00 SV=3 DRG1_HUMAN Developmentally‐regulated GTP‐binding protein 1 1.00 1.00 0.00 OS=Homo sapiens GN=DRG1 PE=1 SV=1 STK10_HUMAN Serine/threonine‐protein kinase 10 OS=Homo sapiens 1.00 1.00 0.00 GN=STK10 PE=1 SV=1 PYGB_HUMAN Glycogen phosphorylase, brain form OS=Homo sapiens 1.00 1.00 0.00 GN=PYGB PE=1 SV=5 RPC2_HUMAN DNA‐directed RNA polymerase III subunit RPC2 1.00 1.00 0.00 OS=Homo sapiens GN=POLR3B PE=1 SV=2 IL2RA_HUMAN Interleukin‐2 receptor subunit alpha OS=Homo sapiens 1.00 1.00 0.00 GN=IL2RA PE=1 SV=1 PKHG5_HUMAN Pleckstrin homology domain‐containing family G 1.00 1.00 0.00 member 5 OS=Homo sapiens GN=PLEKHG5 PE=2 SV=3 FTHFD_HUMAN 10‐formyltetrahydrofolate dehydrogenase OS=Homo 1.00 1.00 0.00 sapiens GN=ALDH1L1 PE=1 SV=2 DCA15_HUMAN DDB1‐ and CUL4‐associated factor 15 OS=Homo 1.00 1.00 0.00 sapiens GN=DCAF15 PE=1 SV=1 SPG17_HUMAN Sperm‐associated antigen 17 OS=Homo sapiens 1.00 1.00 0.00 GN=SPAG17 PE=1 SV=1 IPMK_HUMAN Inositol polyphosphate multikinase OS=Homo sapiens 1.00 1.00 0.00 GN=IPMK PE=1 SV=1 FA83C_HUMAN Protein FAM83C OS=Homo sapiens GN=FAM83C PE=2 1.00 1.00 0.00 SV=3 CS054_HUMAN UPF0692 protein C19orf54 OS=Homo sapiens 1.00 1.00 0.00 GN=C19orf54 PE=1 SV=2 HYDIN_HUMAN Hydrocephalus‐inducing protein homolog OS=Homo 1.00 1.00 0.00

© 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 sapiens GN=HYDIN PE=1 SV=2 GP156_HUMAN Probable G‐protein coupled receptor 156 OS=Homo 1.00 1.00 0.00 sapiens GN=GPR156 PE=2 SV=2 ASSY_HUMAN Argininosuccinate synthase OS=Homo sapiens GN=ASS1 1.00 1.00 0.00 PE=1 SV=2 RPTN_HUMAN Repetin OS=Homo sapiens GN=RPTN PE=1 SV=1 1.00 1.00 0.00 UBP33_HUMAN Ubiquitin carboxyl‐terminal hydrolase 33 OS=Homo 1.00 1.00 0.00 sapiens GN=USP33 PE=1 SV=2 F123C_HUMAN Protein FAM123C OS=Homo sapiens GN=FAM123C 1.00 1.00 0.00 PE=2 SV=2 IRX3_HUMAN Iroquois‐class homeodomain protein IRX‐3 OS=Homo 1.00 1.00 0.00 sapiens GN=IRX3 PE=2 SV=3 CAH1_HUMAN Carbonic anhydrase 1 OS=Homo sapiens GN=CA1 PE=1 1.00 1.00 0.00 SV=2 TTP_HUMAN Tristetraprolin OS=Homo sapiens GN=ZFP36 PE=1 SV=1 1.00 1.00 0.00 MRF_HUMAN Myelin gene regulatory factor OS=Homo sapiens 1.00 1.00 0.00 GN=MRF PE=1 SV=3 DHB1_HUMAN Estradiol 17‐beta‐dehydrogenase 1 OS=Homo sapiens 1.00 1.00 0.00 GN=HSD17B1 PE=1 SV=2 MLL3_HUMAN Histone‐lysine N‐methyltransferase MLL3 OS=Homo 1.00 1.00 0.00 sapiens GN=MLL3 PE=1 SV=3 ACS2B_HUMAN Acyl‐coenzyme A synthetase ACSM2B, mitochondrial 1.00 1.00 0.00 OS=Homo sapiens GN=ACSM2B PE=1 SV=2 JAM3_HUMAN Junctional adhesion molecule C OS=Homo sapiens 1.00 1.00 0.00 GN=JAM3 PE=1 SV=1 WDR92_HUMAN WD repeat‐containing protein 92 OS=Homo sapiens 1.00 1.00 0.00 GN=WDR92 PE=1 SV=1 LDB1_HUMAN LIM domain‐binding protein 1 OS=Homo sapiens 1.00 1.00 0.00 GN=LDB1 PE=1 SV=2 ATR_HUMAN Serine/threonine‐protein kinase ATR OS=Homo sapiens 1.00 1.00 0.00 GN=ATR PE=1 SV=3 IBTK_HUMAN Inhibitor of Bruton tyrosine kinase OS=Homo sapiens 1.00 1.00 0.00 GN=IBTK PE=1 SV=3 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 FA10_HUMAN Coagulation factor X OS=Homo sapiens GN=F10 PE=1 1.00 1.00 0.00 SV=2 VPS41_HUMAN Vacuolar protein sorting‐associated protein 41 1.00 1.00 0.00 homolog OS=Homo sapiens GN=VPS41 PE=1 SV=3 ACE2_HUMAN Angiotensin‐converting enzyme 2 OS=Homo sapiens 1.00 1.00 0.00 GN=ACE2 PE=1 SV=2 ANO5_HUMAN Anoctamin‐5 OS=Homo sapiens GN=ANO5 PE=1 SV=1 1.00 1.00 0.00 SFR16_HUMAN Splicing factor, arginine/serine‐rich 16 OS=Homo 1.00 1.00 0.00 sapiens GN=SFRS16 PE=1 SV=4 EFGM_HUMAN Elongation factor G, mitochondrial OS=Homo sapiens 1.00 1.00 0.00 GN=GFM1 PE=1 SV=2 CNGB1_HUMAN Cyclic nucleotide‐gated cation channel beta‐1 1.00 1.00 0.00 OS=Homo sapiens GN=CNGB1 PE=1 SV=2 RB12B_HUMAN RNA‐binding protein 12B OS=Homo sapiens 1.00 1.00 0.00 GN=RBM12B PE=1 SV=2 PK3C3_HUMAN Phosphatidylinositol 3‐kinase catalytic subunit type 3 1.00 1.00 0.00 OS=Homo sapiens GN=PIK3C3 PE=1 SV=1 EMAL6_HUMAN Echinoderm microtubule‐associated protein‐like 6 1.00 1.00 0.00 OS=Homo sapiens GN=EML6 PE=2 SV=2 PTTG_HUMAN Pituitary tumor‐transforming gene 1 protein‐interacting 1.00 1.00 0.00 protein OS=Homo sapiens GN=PTTG1IP PE=1 SV=1 DDR1_HUMAN Epithelial discoidin domain‐containing receptor 1 1.00 1.00 0.00 OS=Homo sapiens GN=DDR1 PE=1 SV=1 DPP2_HUMAN Dipeptidyl peptidase 2 OS=Homo sapiens GN=DPP7 1.00 1.00 0.00 PE=1 SV=3 SAP_HUMAN Proactivator polypeptide OS=Homo sapiens GN=PSAP 1.00 1.00 0.00 PE=1 SV=2 LY6D_HUMAN Lymphocyte antigen 6D OS=Homo sapiens GN=LY6D 1.00 1.00 0.00 PE=1 SV=1 A4_HUMAN Amyloid beta A4 protein OS=Homo sapiens GN=APP PE=1 1.00 1.00 0.00 SV=3 GLU2B_HUMAN Glucosidase 2 subunit beta OS=Homo sapiens 1.00 1.00 0.00 GN=PRKCSH PE=1 SV=2

© 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 ZBT46_HUMAN Zinc finger and BTB domain‐containing protein 46 1.00 1.00 0.00 OS=Homo sapiens GN=ZBTB46 PE=2 SV=2 ICAM1_HUMAN Intercellular adhesion molecule 1 OS=Homo sapiens 1.00 1.00 0.00 GN=ICAM1 PE=1 SV=2 BGLR_HUMAN Beta‐glucuronidase OS=Homo sapiens GN=GUSB PE=1 1.00 1.00 0.00 SV=2 GALM_HUMAN Aldose 1‐epimerase OS=Homo sapiens GN=GALM PE=1 1.00 1.00 0.00 SV=1 LYVE1_HUMAN Lymphatic vessel endothelial hyaluronic acid receptor 1.00 1.00 0.00 1 OS=Homo sapiens GN=LYVE1 PE=1 SV=2 CLC4G_HUMAN C‐type lectin domain family 4 member G OS=Homo 1.00 1.00 0.00 sapiens GN=CLEC4G PE=1 SV=1 NCAN_HUMAN Neurocan core protein OS=Homo sapiens GN=NCAN 1.00 1.00 0.00 PE=2 SV=3 FA59A_HUMAN Protein FAM59A OS=Homo sapiens GN=FAM59A PE=1 1.00 1.00 0.00 SV=2 TRBM_HUMAN Thrombomodulin OS=Homo sapiens GN=THBD PE=1 1.00 1.00 0.00 SV=2 PRAX_HUMAN Periaxin OS=Homo sapiens GN=PRX PE=1 SV=1 1.00 1.00 0.00 ANTR1_HUMAN Anthrax toxin receptor 1 OS=Homo sapiens 1.00 1.00 0.00 GN=ANTXR1 PE=1 SV=2 ZN638_HUMAN Zinc finger protein 638 OS=Homo sapiens GN=ZNF638 1.00 1.00 0.00 PE=1 SV=2 ASGR2_HUMAN Asialoglycoprotein receptor 2 OS=Homo sapiens 1.00 1.00 0.00 GN=ASGR2 PE=1 SV=2 F193A_HUMAN Protein FAM193A OS=Homo sapiens GN=FAM193A 1.00 1.00 0.00 PE=1 SV=2 KI2S1_HUMAN Killer cell immunoglobulin‐like receptor 2DS1 OS=Homo 1.00 1.00 0.00 sapiens GN=KIR2DS1 PE=2 SV=1 CQ037_HUMAN Protein C17orf37 OS=Homo sapiens GN=C17orf37 1.00 1.00 0.00 PE=1 SV=1 CIR1_HUMAN Corepressor interacting with RBPJ 1 OS=Homo sapiens 1.00 1.00 0.00 GN=CIR1 PE=1 SV=1

© 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 FGFR2_HUMAN Fibroblast growth factor receptor 2 OS=Homo sapiens 1.00 1.00 0.00 GN=FGFR2 PE=1 SV=1 TCRG1_HUMAN Transcription elongation regulator 1 OS=Homo sapiens 1.00 1.00 0.00 GN=TCERG1 PE=1 SV=2 HV310_HUMAN Ig heavy chain V‐III region HIL OS=Homo sapiens PE=1 1.00 1.00 0.00 SV=1 AATC_HUMAN Aspartate aminotransferase, cytoplasmic OS=Homo 1.00 1.00 0.00 sapiens GN=GOT1 PE=1 SV=3 PLBL2_HUMAN Putative phospholipase B‐like 2 OS=Homo sapiens 1.00 1.00 0.00 GN=PLBD2 PE=1 SV=2 FCGBP_HUMAN IgGFc‐binding protein OS=Homo sapiens GN=FCGBP 2.00 2.00 0.00 PE=1 SV=3 RETN_HUMAN Resistin OS=Homo sapiens GN=RETN PE=2 SV=1 2.00 2.00 0.00 MYL6_HUMAN Myosin light polypeptide 6 OS=Homo sapiens GN=MYL6 3.00 3.00 0.00 PE=1 SV=2 SZT2_HUMAN Protein SZT2 OS=Homo sapiens GN=SZT2 PE=2 SV=3 3.00 3.00 0.00 G3P_HUMAN Glyceraldehyde‐3‐phosphate dehydrogenase OS=Homo 3.00 3.00 0.00 sapiens GN=GAPDH PE=1 SV=3 CUBN_HUMAN Cubilin OS=Homo sapiens GN=CUBN PE=1 SV=5 0.11 0.11 0.00 EPCR_HUMAN Endothelial protein C receptor OS=Homo sapiens 0.69 0.67 0.02 GN=PROCR PE=1 SV=1 BTD_HUMAN Biotinidase OS=Homo sapiens GN=BTD PE=1 SV=2 0.13 0.10 0.03 BGAL_HUMAN Beta‐galactosidase OS=Homo sapiens GN=GLB1 PE=1 0.20 0.17 0.03 SV=2 PVRL4_HUMAN Poliovirus receptor‐related protein 4 OS=Homo 0.17 0.13 0.04 sapiens GN=PVRL4 PE=1 SV=1 A1BG_HUMAN Alpha‐1B‐glycoprotein OS=Homo sapiens GN=A1BG 1.62 1.57 0.04 PE=1 SV=3 ANAG_HUMAN Alpha‐N‐acetylglucosaminidase OS=Homo sapiens 0.10 0.02 0.07 GN=NAGLU PE=1 SV=1 BCAM_HUMAN Basal cell adhesion molecule OS=Homo sapiens 0.14 0.07 0.08 GN=BCAM PE=1 SV=2 MEGF8_HUMAN Multiple epidermal growth factor‐like domains 0.20 0.11 0.09 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 protein 8 OS=Homo sapiens GN=MEGF8 PE=1 SV=2 CATD_HUMAN Cathepsin D OS=Homo sapiens GN=CTSD PE=1 SV=1 0.20 0.11 0.09 A2MG_HUMAN Alpha‐2‐macroglobulin OS=Homo sapiens GN=A2M 22.27 22.18 0.09 PE=1 SV=3 TENA_HUMAN Tenascin OS=Homo sapiens GN=TNC PE=1 SV=3 0.69 0.59 0.10 ROBO4_HUMAN Roundabout homolog 4 OS=Homo sapiens 0.24 0.13 0.11 GN=ROBO4 PE=1 SV=1 MUC1_HUMAN Mucin‐1 OS=Homo sapiens GN=MUC1 PE=1 SV=3 0.45 0.34 0.11 CO6A1_HUMAN Collagen alpha‐1(VI) chain OS=Homo sapiens 0.17 0.04 0.13 GN=COL6A1 PE=1 SV=3 S12A1_HUMAN Solute carrier family 12 member 1 OS=Homo sapiens 0.33 0.20 0.13 GN=SLC12A1 PE=1 SV=2 FINC_HUMAN Fibronectin OS=Homo sapiens GN=FN1 PE=1 SV=4 0.85 0.71 0.14 PEPA_HUMAN Pepsin A OS=Homo sapiens GN=PGA3 PE=1 SV=1 0.33 0.18 0.15 PTGDS_HUMAN Prostaglandin‐H2 D‐isomerase OS=Homo sapiens 0.86 0.71 0.16 GN=PTGDS PE=1 SV=1 TGM3_HUMAN Protein‐glutamine gamma‐glutamyltransferase E 0.50 0.34 0.16 OS=Homo sapiens GN=TGM3 PE=1 SV=4 CD14_HUMAN Monocyte differentiation antigen CD14 OS=Homo 0.25 0.09 0.16 sapiens GN=CD14 PE=1 SV=2 RNAS2_HUMAN Non‐secretory ribonuclease OS=Homo sapiens 0.44 0.28 0.16 GN=RNASE2 PE=1 SV=2 SLAF5_HUMAN SLAM family member 5 OS=Homo sapiens GN=CD84 0.67 0.50 0.17 PE=1 SV=1 ROR2_HUMAN Tyrosine‐protein kinase transmembrane receptor ROR2 0.67 0.50 0.17 OS=Homo sapiens GN=ROR2 PE=1 SV=2 FAM3C_HUMAN Protein FAM3C OS=Homo sapiens GN=FAM3C PE=1 0.50 0.33 0.17 SV=1 APOA4_HUMAN Apolipoprotein A‐IV OS=Homo sapiens GN=APOA4 0.50 0.33 0.17 PE=1 SV=3 CATZ_HUMAN Cathepsin Z OS=Homo sapiens GN=CTSZ PE=1 SV=1 0.50 0.33 0.17 IPO8_HUMAN Importin‐8 OS=Homo sapiens GN=IPO8 PE=1 SV=2 0.50 0.33 0.17 SPHM_HUMAN N‐sulphoglucosamine sulphohydrolase OS=Homo 0.50 0.33 0.17 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 sapiens GN=SGSH PE=1 SV=1 FABPL_HUMAN Fatty acid‐binding protein, liver OS=Homo sapiens 0.50 0.33 0.17 GN=FABP1 PE=1 SV=1 CAH2_HUMAN Carbonic anhydrase 2 OS=Homo sapiens GN=CA2 PE=1 0.25 0.07 0.18 SV=2 F16P1_HUMAN Fructose‐1,6‐bisphosphatase 1 OS=Homo sapiens 0.33 0.14 0.19 GN=FBP1 PE=1 SV=5 ICOSL_HUMAN ICOS ligand OS=Homo sapiens GN=ICOSLG PE=1 SV=2 0.44 0.25 0.19 CD44_HUMAN CD44 antigen OS=Homo sapiens GN=CD44 PE=1 SV=3 0.62 0.41 0.21 IBP7_HUMAN Insulin‐like growth factor‐binding protein 7 OS=Homo 0.53 0.31 0.22 sapiens GN=IGFBP7 PE=1 SV=1 SDC1_HUMAN Syndecan‐1 OS=Homo sapiens GN=SDC1 PE=1 SV=3 0.33 0.11 0.22 APOD_HUMAN Apolipoprotein D OS=Homo sapiens GN=APOD PE=1 1.00 0.78 0.22 SV=1 SPB4_HUMAN Serpin B4 OS=Homo sapiens GN=SERPINB4 PE=1 SV=2 3.50 3.28 0.22 SCG1_HUMAN Secretogranin‐1 OS=Homo sapiens GN=CHGB PE=1 0.57 0.33 0.24 SV=2 OPCM_HUMAN Opioid‐binding protein/cell adhesion molecule 0.33 0.09 0.24 OS=Homo sapiens GN=OPCML PE=1 SV=1 MA1A1_HUMAN Mannosyl‐oligosaccharide 1,2‐alpha‐mannosidase IA 0.33 0.09 0.24 OS=Homo sapiens GN=MAN1A1 PE=1 SV=3 NHLC3_HUMAN NHL repeat‐containing protein 3 OS=Homo sapiens 0.50 0.25 0.25 GN=NHLRC3 PE=2 SV=1 FETUA_HUMAN Alpha‐2‐HS‐glycoprotein OS=Homo sapiens GN=AHSG 1.00 0.75 0.25 PE=1 SV=1 NPC2_HUMAN Epididymal secretory protein E1 OS=Homo sapiens 1.00 0.75 0.25 GN=NPC2 PE=1 SV=1 PPAP_HUMAN Prostatic acid phosphatase OS=Homo sapiens GN=ACPP 0.45 0.20 0.25 PE=1 SV=3 BT2A2_HUMAN Butyrophilin subfamily 2 member A2 OS=Homo 0.82 0.55 0.28 sapiens GN=BTN2A2 PE=2 SV=2 K2C5_HUMAN Keratin, type II cytoskeletal 5 OS=Homo sapiens 0.79 0.51 0.28 GN=KRT5 PE=1 SV=3 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 PPAL_HUMAN Lysosomal acid phosphatase OS=Homo sapiens 0.38 0.09 0.28 GN=ACP2 PE=1 SV=3 FILA_HUMAN Filaggrin OS=Homo sapiens GN=FLG PE=1 SV=3 0.44 0.14 0.30 DIAC_HUMAN Di‐N‐acetylchitobiase OS=Homo sapiens GN=CTBS PE=1 0.50 0.20 0.30 SV=1 B2MG_HUMAN Beta‐2‐microglobulin OS=Homo sapiens GN=B2M PE=1 0.58 0.25 0.33 SV=1 FBN1_HUMAN Fibrillin‐1 OS=Homo sapiens GN=FBN1 PE=1 SV=3 1.33 1.00 0.33 PRSS8_HUMAN Prostasin OS=Homo sapiens GN=PRSS8 PE=1 SV=1 0.50 0.17 0.33 EZRI_HUMAN Ezrin OS=Homo sapiens GN=EZR PE=1 SV=4 0.50 0.17 0.33 PSCA_HUMAN Prostate stem cell antigen OS=Homo sapiens GN=PSCA 1.00 0.67 0.33 PE=1 SV=1 LAIR1_HUMAN Leukocyte‐associated immunoglobulin‐like receptor 1 1.07 0.74 0.33 OS=Homo sapiens GN=LAIR1 PE=1 SV=1 AMBP_HUMAN Protein AMBP OS=Homo sapiens GN=AMBP PE=1 SV=1 0.95 0.60 0.36 GPX3_HUMAN Glutathione peroxidase 3 OS=Homo sapiens GN=GPX3 0.50 0.14 0.36 PE=1 SV=2 KNG1_HUMAN Kininogen‐1 OS=Homo sapiens GN=KNG1 PE=1 SV=2 0.59 0.22 0.37 SHPS1_HUMAN Tyrosine‐protein phosphatase non‐receptor type 1.00 0.63 0.38 substrate 1 OS=Homo sapiens GN=SIRPA PE=1 SV=1 K2C6B_HUMAN Keratin, type II cytoskeletal 6B OS=Homo sapiens 1.00 0.62 0.38 GN=KRT6B PE=1 SV=5 CAD13_HUMAN Cadherin‐13 OS=Homo sapiens GN=CDH13 PE=1 SV=1 1.08 0.69 0.39 ARSA_HUMAN Arylsulfatase A OS=Homo sapiens GN=ARSA PE=1 SV=3 0.52 0.11 0.42 CSPG4_HUMAN Chondroitin sulfate proteoglycan 4 OS=Homo sapiens 0.48 0.06 0.42 GN=CSPG4 PE=1 SV=2 IC1_HUMAN Plasma protease C1 inhibitor OS=Homo sapiens 1.36 0.94 0.42 GN=SERPING1 PE=1 SV=2 ALDR_HUMAN Aldose reductase OS=Homo sapiens GN=AKR1B1 PE=1 0.50 0.07 0.43 SV=3 SIRBL_HUMAN Signal‐regulatory protein beta‐1 isoform 3 OS=Homo 1.00 0.56 0.44 sapiens GN=SIRPB1 PE=1 SV=1 KLK1_HUMAN Kallikrein‐1 OS=Homo sapiens GN=KLK1 PE=1 SV=2 1.07 0.59 0.48 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 PCDGK_HUMAN Protocadherin gamma‐C3 OS=Homo sapiens 1.00 0.50 0.50 GN=PCDHGC3 PE=1 SV=1 SPIT2_HUMAN Kunitz‐type protease inhibitor 2 OS=Homo sapiens 1.00 0.50 0.50 GN=SPINT2 PE=1 SV=2 DERM_HUMAN Dermatopontin OS=Homo sapiens GN=DPT PE=2 SV=2 1.00 0.50 0.50 VCAM1_HUMAN Vascular cell adhesion protein 1 OS=Homo sapiens 1.00 0.50 0.50 GN=VCAM1 PE=1 SV=1 COCH_HUMAN Cochlin OS=Homo sapiens GN=COCH PE=1 SV=1 1.00 0.50 0.50 CEL2A_HUMAN Chymotrypsin‐like elastase family member 2A 1.00 0.50 0.50 OS=Homo sapiens GN=CELA2A PE=1 SV=1 PARK7_HUMAN Protein DJ‐1 OS=Homo sapiens GN=PARK7 PE=1 SV=2 1.00 0.50 0.50 DSC3_HUMAN Desmocollin‐3 OS=Homo sapiens GN=DSC3 PE=1 SV=3 1.00 0.50 0.50 CADM1_HUMAN Cell adhesion molecule 1 OS=Homo sapiens 1.00 0.50 0.50 GN=CADM1 PE=1 SV=2 B3GN1_HUMAN N‐acetyllactosaminide beta‐1,3‐N‐ 1.00 0.50 0.50 acetylglucosaminyltransferase OS=Homo sapiens GN=B3GNT1 PE=1 SV=1 ACPH_HUMAN Acylamino‐acid‐releasing enzyme OS=Homo sapiens 1.00 0.50 0.50 GN=APEH PE=1 SV=4 CBPE_HUMAN Carboxypeptidase E OS=Homo sapiens GN=CPE PE=1 1.00 0.50 0.50 SV=1 PLBL1_HUMAN Putative phospholipase B‐like 1 OS=Homo sapiens 1.00 0.50 0.50 GN=PLBD1 PE=1 SV=2 PCSK1_HUMAN ProSAAS OS=Homo sapiens GN=PCSK1N PE=1 SV=1 1.00 0.50 0.50 S26A4_HUMAN Pendrin OS=Homo sapiens GN=SLC26A4 PE=1 SV=1 1.00 0.50 0.50 F151A_HUMAN Protein FAM151A OS=Homo sapiens GN=FAM151A 1.00 0.50 0.50 PE=2 SV=2 MDR1_HUMAN Multidrug resistance protein 1 OS=Homo sapiens 1.00 0.50 0.50 GN=ABCB1 PE=1 SV=3 SPIT1_HUMAN Kunitz‐type protease inhibitor 1 OS=Homo sapiens 1.00 0.50 0.50 GN=SPINT1 PE=1 SV=2 RNAS1_HUMAN Ribonuclease pancreatic OS=Homo sapiens 1.00 0.50 0.50 GN=RNASE1 PE=1 SV=4 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 GP180_HUMAN Integral membrane protein GPR180 OS=Homo sapiens 1.00 0.50 0.50 GN=GPR180 PE=2 SV=1 CGAT1_HUMAN Chondroitin sulfate N‐acetylgalactosaminyltransferase 1.00 0.50 0.50 1 OS=Homo sapiens GN=CSGALNACT1 PE=1 SV=2 ADSV_HUMAN Adseverin OS=Homo sapiens GN=SCIN PE=1 SV=4 1.00 0.50 0.50 S10A6_HUMAN Protein S100‐A6 OS=Homo sapiens GN=S100A6 PE=1 1.00 0.50 0.50 SV=1 AUGN_HUMAN Augurin OS=Homo sapiens GN=C2orf40 PE=1 SV=1 1.00 0.50 0.50 DCNL3_HUMAN DCN1‐like protein 3 OS=Homo sapiens GN=DCUN1D3 1.00 0.50 0.50 PE=2 SV=1 FUMH_HUMAN Fumarate hydratase, mitochondrial OS=Homo sapiens 1.00 0.50 0.50 GN=FH PE=1 SV=3 ZNF77_HUMAN Zinc finger protein 77 OS=Homo sapiens GN=ZNF77 1.00 0.50 0.50 PE=2 SV=2 PP14C_HUMAN Protein phosphatase 1 regulatory subunit 14C 1.00 0.50 0.50 OS=Homo sapiens GN=PPP1R14C PE=1 SV=3 ISLR_HUMAN Immunoglobulin superfamily containing leucine‐rich 1.00 0.50 0.50 repeat protein OS=Homo sapiens GN=ISLR PE=1 SV=1 GALNS_HUMAN N‐acetylgalactosamine‐6‐sulfatase OS=Homo sapiens 1.00 0.50 0.50 GN=GALNS PE=1 SV=1 GGT6_HUMAN Gamma‐glutamyltransferase 6 OS=Homo sapiens 1.00 0.50 0.50 GN=GGT6 PE=2 SV=2 SBP1_HUMAN Selenium‐binding protein 1 OS=Homo sapiens 1.00 0.50 0.50 GN=SELENBP1 PE=1 SV=2 CSF1_HUMAN Macrophage colony‐stimulating factor 1 OS=Homo 1.00 0.50 0.50 sapiens GN=CSF1 PE=1 SV=2 CAD15_HUMAN Cadherin‐15 OS=Homo sapiens GN=CDH15 PE=1 SV=1 1.50 1.00 0.50 CNTFR_HUMAN Ciliary neurotrophic factor receptor subunit alpha 0.71 0.20 0.51 OS=Homo sapiens GN=CNTFR PE=1 SV=2 IPSP_HUMAN Plasma serine protease inhibitor OS=Homo sapiens 0.87 0.35 0.52 GN=SERPINA5 PE=1 SV=2 PGK1_HUMAN Phosphoglycerate kinase 1 OS=Homo sapiens GN=PGK1 0.67 0.14 0.52 PE=1 SV=3 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 C1RL_HUMAN Complement C1r subcomponent‐like protein OS=Homo 0.69 0.17 0.53 sapiens GN=C1RL PE=1 SV=2 FIBA_HUMAN Fibrinogen alpha chain OS=Homo sapiens GN=FGA PE=1 1.44 0.92 0.53 SV=2 UROM_HUMAN Uromodulin OS=Homo sapiens GN=UMOD PE=1 SV=1 1.06 0.53 0.53 MXRA8_HUMAN Matrix‐remodeling‐associated protein 8 OS=Homo 0.86 0.33 0.53 sapiens GN=MXRA8 PE=1 SV=1 ZA2G_HUMAN Zinc‐alpha‐2‐glycoprotein OS=Homo sapiens GN=AZGP1 1.31 0.77 0.54 PE=1 SV=2 MASP2_HUMAN Mannan‐binding lectin serine protease 2 OS=Homo 0.74 0.18 0.56 sapiens GN=MASP2 PE=1 SV=3 NID1_HUMAN Nidogen‐1 OS=Homo sapiens GN=NID1 PE=1 SV=3 0.94 0.38 0.56 DNAS1_HUMAN Deoxyribonuclease‐1 OS=Homo sapiens GN=DNASE1 0.92 0.35 0.57 PE=1 SV=1 PIP_HUMAN Prolactin‐inducible protein OS=Homo sapiens GN=PIP 1.00 0.43 0.57 PE=1 SV=1 DPP4_HUMAN Dipeptidyl peptidase 4 OS=Homo sapiens GN=DPP4 0.68 0.11 0.57 PE=1 SV=2 A1AG2_HUMAN Alpha‐1‐acid glycoprotein 2 OS=Homo sapiens 1.85 1.27 0.57 GN=ORM2 PE=1 SV=2 REG1A_HUMAN Lithostathine‐1‐alpha OS=Homo sapiens GN=REG1A 1.00 0.40 0.60 PE=1 SV=3 OSTP_HUMAN Osteopontin OS=Homo sapiens GN=SPP1 PE=1 SV=1 1.14 0.53 0.62 IGHG2_HUMAN Ig gamma‐2 chain C region OS=Homo sapiens 1.48 0.86 0.62 GN=IGHG2 PE=1 SV=2 PODXL_HUMAN Podocalyxin OS=Homo sapiens GN=PODXL PE=1 SV=2 1.13 0.50 0.63 CD59_HUMAN CD59 glycoprotein OS=Homo sapiens GN=CD59 PE=1 0.81 0.18 0.63 SV=1 DSG1_HUMAN Desmoglein‐1 OS=Homo sapiens GN=DSG1 PE=1 SV=2 1.00 0.37 0.63 CAD11_HUMAN Cadherin‐11 OS=Homo sapiens GN=CDH11 PE=1 SV=2 0.88 0.24 0.64 ARGI1_HUMAN Arginase‐1 OS=Homo sapiens GN=ARG1 PE=1 SV=2 2.00 1.35 0.65 SPB3_HUMAN Serpin B3 OS=Homo sapiens GN=SERPINB3 PE=1 SV=2 2.82 2.17 0.65 CADM4_HUMAN Cell adhesion molecule 4 OS=Homo sapiens 0.87 0.21 0.66 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 GN=CADM4 PE=1 SV=1 SULF2_HUMAN Extracellular sulfatase Sulf‐2 OS=Homo sapiens 1.33 0.67 0.67 GN=SULF2 PE=1 SV=1 ANX11_HUMAN Annexin A11 OS=Homo sapiens GN=ANXA11 PE=1 1.00 0.33 0.67 SV=1 QOR_HUMAN Quinone oxidoreductase OS=Homo sapiens GN=CRYZ 1.00 0.33 0.67 PE=1 SV=1 ESAM_HUMAN Endothelial cell‐selective adhesion molecule OS=Homo 1.00 0.33 0.67 sapiens GN=ESAM PE=1 SV=1 CBPA1_HUMAN Carboxypeptidase A1 OS=Homo sapiens GN=CPA1 1.00 0.33 0.67 PE=1 SV=2 HEXB_HUMAN Beta‐hexosaminidase subunit beta OS=Homo sapiens 1.00 0.33 0.67 GN=HEXB PE=1 SV=3 DSC1_HUMAN Desmocollin‐1 OS=Homo sapiens GN=DSC1 PE=1 SV=2 1.00 0.33 0.67 GUC2A_HUMAN Guanylin OS=Homo sapiens GN=GUCA2A PE=1 SV=2 1.00 0.33 0.67 IL6RB_HUMAN Interleukin‐6 receptor subunit beta OS=Homo sapiens 1.00 0.33 0.67 GN=IL6ST PE=1 SV=2 RNT2_HUMAN Ribonuclease T2 OS=Homo sapiens GN=RNASET2 PE=1 1.00 0.33 0.67 SV=2 S12A3_HUMAN Solute carrier family 12 member 3 OS=Homo sapiens 1.00 0.33 0.67 GN=SLC12A3 PE=1 SV=2 IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytoplasmic OS=Homo 1.17 0.50 0.67 sapiens GN=IDH1 PE=1 SV=2 APOA2_HUMAN Apolipoprotein A‐II OS=Homo sapiens GN=APOA2 1.67 1.00 0.67 PE=1 SV=1 LMAN2_HUMAN Vesicular integral‐membrane protein VIP36 OS=Homo 1.05 0.38 0.67 sapiens GN=LMAN2 PE=1 SV=1 IGKC_HUMAN Ig kappa chain C region OS=Homo sapiens GN=IGKC 1.78 1.11 0.68 PE=1 SV=1 HMCN1_HUMAN Hemicentin‐1 OS=Homo sapiens GN=HMCN1 PE=1 0.78 0.10 0.68 SV=2 IGSF8_HUMAN Immunoglobulin superfamily member 8 OS=Homo 0.80 0.11 0.69 sapiens GN=IGSF8 PE=1 SV=1 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 AXA2L_HUMAN Putative annexin A2‐like protein OS=Homo sapiens 2.25 1.55 0.70 GN=ANXA2P2 PE=5 SV=2 K1C13_HUMAN Keratin, type I cytoskeletal 13 OS=Homo sapiens 1.55 0.83 0.71 GN=KRT13 PE=1 SV=4 ITIH4_HUMAN Inter‐alpha‐trypsin inhibitor heavy chain H4 OS=Homo 0.91 0.20 0.72 sapiens GN=ITIH4 PE=1 SV=4 SIAE_HUMAN Sialate O‐acetylesterase OS=Homo sapiens GN=SIAE 1.00 0.27 0.73 PE=1 SV=1 SPB12_HUMAN Serpin B12 OS=Homo sapiens GN=SERPINB12 PE=1 2.00 1.27 0.73 SV=1 SODE_HUMAN Extracellular superoxide dismutase [Cu‐Zn] OS=Homo 0.89 0.16 0.73 sapiens GN=SOD3 PE=1 SV=2 TGON2_HUMAN Trans‐Golgi network integral membrane protein 2 1.00 0.25 0.75 OS=Homo sapiens GN=TGOLN2 PE=1 SV=2 GSHR_HUMAN Glutathione reductase, mitochondrial OS=Homo 1.00 0.25 0.75 sapiens GN=GSR PE=1 SV=2 UROK_HUMAN Urokinase‐type plasminogen activator OS=Homo 1.00 0.25 0.75 sapiens GN=PLAU PE=1 SV=2 CALB1_HUMAN Calbindin OS=Homo sapiens GN=CALB1 PE=1 SV=2 1.00 0.25 0.75 PGCP_HUMAN Plasma glutamate carboxypeptidase OS=Homo sapiens 1.00 0.25 0.75 GN=PGCP PE=1 SV=1 CD276_HUMAN CD276 antigen OS=Homo sapiens GN=CD276 PE=1 1.25 0.50 0.75 SV=1 HEMO_HUMAN Hemopexin OS=Homo sapiens GN=HPX PE=1 SV=2 3.17 2.41 0.75 LAC2_HUMAN Ig lambda‐2 chain C regions OS=Homo sapiens 2.64 1.86 0.77 GN=IGLC2 PE=1 SV=1 RAI3_HUMAN Retinoic acid‐induced protein 3 OS=Homo sapiens 1.00 0.20 0.80 GN=GPRC5A PE=1 SV=2 CK054_HUMAN Ester hydrolase C11orf54 OS=Homo sapiens 1.00 0.20 0.80 GN=C11orf54 PE=1 SV=1 FUCO_HUMAN Tissue alpha‐L‐fucosidase OS=Homo sapiens GN=FUCA1 1.00 0.20 0.80 PE=1 SV=4 MMRN2_HUMAN Multimerin‐2 OS=Homo sapiens GN=MMRN2 PE=1 1.00 0.20 0.80 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 SV=2 LDHB_HUMAN L‐lactate dehydrogenase B chain OS=Homo sapiens 0.85 0.05 0.80 GN=LDHB PE=1 SV=2 PGBM_HUMAN Basement membrane‐specific heparan sulfate 1.20 0.39 0.81 proteoglycan core protein OS=Homo sapiens GN=HSPG2 PE=1 SV=3 PIGR_HUMAN Polymeric immunoglobulin receptor OS=Homo sapiens 1.57 0.75 0.82 GN=PIGR PE=1 SV=4 VTCN1_HUMAN V‐set domain‐containing T‐cell activation inhibitor 1 1.00 0.14 0.86 OS=Homo sapiens GN=VTCN1 PE=1 SV=1 LAC1_HUMAN Ig lambda‐1 chain C regions OS=Homo sapiens 2.60 1.73 0.87 GN=IGLC1 PE=1 SV=1 EGF_HUMAN Pro‐epidermal growth factor OS=Homo sapiens GN=EGF 1.05 0.16 0.88 PE=1 SV=2 K2C6A_HUMAN Keratin, type II cytoskeletal 6A OS=Homo sapiens 1.42 0.53 0.89 GN=KRT6A PE=1 SV=3 CD9_HUMAN CD9 antigen OS=Homo sapiens GN=CD9 PE=1 SV=4 1.00 0.11 0.89 PVR_HUMAN Poliovirus receptor OS=Homo sapiens GN=PVR PE=1 1.12 0.22 0.90 SV=2 PPIA_HUMAN Peptidyl‐prolyl cis‐trans isomerase A OS=Homo sapiens 1.83 0.93 0.90 GN=PPIA PE=1 SV=2 A2GL_HUMAN Leucine‐rich alpha‐2‐glycoprotein OS=Homo sapiens 1.57 0.64 0.93 GN=LRG1 PE=1 SV=2 ATRN_HUMAN Attractin OS=Homo sapiens GN=ATRN PE=1 SV=2 1.26 0.32 0.94 AMY1_HUMAN Alpha‐amylase 1 OS=Homo sapiens GN=AMY1A PE=1 1.00 0.03 0.97 SV=2 AGRIN_HUMAN Agrin OS=Homo sapiens GN=AGRN PE=1 SV=4 1.20 0.22 0.98 PEBP1_HUMAN Phosphatidylethanolamine‐binding protein 1 1.40 0.42 0.98 OS=Homo sapiens GN=PEBP1 PE=1 SV=3 SCTM1_HUMAN Secreted and transmembrane protein 1 OS=Homo 1.33 0.34 0.99 sapiens GN=SECTM1 PE=1 SV=2 CD7_HUMAN T‐cell antigen CD7 OS=Homo sapiens GN=CD7 PE=1 SV=1 1.33 0.33 1.00 TWSG1_HUMAN Twisted gastrulation protein homolog 1 OS=Homo 1.33 0.33 1.00 sapiens GN=TWSG1 PE=2 SV=1 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 LDHA_HUMAN L‐lactate dehydrogenase A chain OS=Homo sapiens 2.00 1.00 1.00 GN=LDHA PE=1 SV=2 CALL3_HUMAN Calmodulin‐like protein 3 OS=Homo sapiens 2.00 1.00 1.00 GN=CALML3 PE=1 SV=2 DESP_HUMAN Desmoplakin OS=Homo sapiens GN=DSP PE=1 SV=3 2.00 1.00 1.00 PCD12_HUMAN Protocadherin‐12 OS=Homo sapiens GN=PCDH12 PE=2 2.00 1.00 1.00 SV=1 SH3L1_HUMAN SH3 domain‐binding glutamic acid‐rich‐like protein 2.00 1.00 1.00 OS=Homo sapiens GN=SH3BGRL PE=1 SV=1 LEG3_HUMAN Galectin‐3 OS=Homo sapiens GN=LGALS3 PE=1 SV=5 2.00 1.00 1.00 CRGD_HUMAN Gamma‐crystallin D OS=Homo sapiens GN=CRYGD PE=1 2.00 1.00 1.00 SV=3 PSB6_HUMAN Proteasome subunit beta type‐6 OS=Homo sapiens 2.00 1.00 1.00 GN=PSMB6 PE=1 SV=4 SHBG_HUMAN Sex hormone‐binding globulin OS=Homo sapiens 2.00 1.00 1.00 GN=SHBG PE=1 SV=2 CEAM6_HUMAN Carcinoembryonic antigen‐related cell adhesion 2.00 1.00 1.00 molecule 6 OS=Homo sapiens GN=CEACAM6 PE=1 SV=3 A2AP_HUMAN Alpha‐2‐antiplasmin OS=Homo sapiens GN=SERPINF2 2.00 1.00 1.00 PE=1 SV=3 PDIA1_HUMAN Protein disulfide‐isomerase OS=Homo sapiens 2.00 1.00 1.00 GN=P4HB PE=1 SV=3 FCN2_HUMAN Ficolin‐2 OS=Homo sapiens GN=FCN2 PE=1 SV=2 2.00 1.00 1.00 UTER_HUMAN Uteroglobin OS=Homo sapiens GN=SCGB1A1 PE=1 SV=1 2.00 1.00 1.00 PRAM_HUMAN PML‐RARA‐regulated adapter molecule 1 OS=Homo 2.00 1.00 1.00 sapiens GN=PRAM1 PE=1 SV=1 1433T_HUMAN 14‐3‐3 protein theta OS=Homo sapiens GN=YWHAQ 2.00 1.00 1.00 PE=1 SV=1 PRDX1_HUMAN Peroxiredoxin‐1 OS=Homo sapiens GN=PRDX1 PE=1 2.00 1.00 1.00 SV=1 DYDC2_HUMAN DPY30 domain‐containing protein 2 OS=Homo sapiens 2.00 1.00 1.00 GN=DYDC2 PE=1 SV=1 GLOD4_HUMAN Glyoxalase domain‐containing protein 4 OS=Homo 2.00 1.00 1.00 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 sapiens GN=GLOD4 PE=1 SV=1 LV403_HUMAN Ig lambda chain V‐IV region Hil OS=Homo sapiens PE=1 2.00 1.00 1.00 SV=1 CHIT1_HUMAN Chitotriosidase‐1 OS=Homo sapiens GN=CHIT1 PE=1 3.00 2.00 1.00 SV=1 CBG_HUMAN Corticosteroid‐binding globulin OS=Homo sapiens 3.00 2.00 1.00 GN=SERPINA6 PE=1 SV=1 PNPH_HUMAN Purine nucleoside phosphorylase OS=Homo sapiens 3.00 2.00 1.00 GN=PNP PE=1 SV=2 PROF1_HUMAN Profilin‐1 OS=Homo sapiens GN=PFN1 PE=1 SV=2 7.00 6.00 1.00 SIRB1_HUMAN Signal‐regulatory protein beta‐1 OS=Homo sapiens 1.40 0.38 1.03 GN=SIRPB1 PE=1 SV=5 VTDB_HUMAN Vitamin D‐binding protein OS=Homo sapiens GN=GC 2.38 1.35 1.03 PE=1 SV=1 FCG3A_HUMAN Low affinity immunoglobulin gamma Fc region 1.44 0.38 1.06 receptor III‐A OS=Homo sapiens GN=FCGR3A PE=2 SV=2 K2C6C_HUMAN Keratin, type II cytoskeletal 6C OS=Homo sapiens 1.64 0.53 1.11 GN=KRT6C PE=1 SV=3 UFO_HUMAN Tyrosine‐protein kinase receptor UFO OS=Homo sapiens 1.40 0.27 1.13 GN=AXL PE=1 SV=3 ITIH1_HUMAN Inter‐alpha‐trypsin inhibitor heavy chain H1 OS=Homo 2.00 0.86 1.14 sapiens GN=ITIH1 PE=1 SV=3 HV320_HUMAN Ig heavy chain V‐III region GAL OS=Homo sapiens PE=1 2.14 1.00 1.14 SV=1 CUTA_HUMAN Protein CutA OS=Homo sapiens GN=CUTA PE=1 SV=2 1.50 0.33 1.17 TETN_HUMAN Tetranectin OS=Homo sapiens GN=CLEC3B PE=1 SV=2 1.50 0.33 1.17 HSP72_HUMAN Heat shock‐related 70 kDa protein 2 OS=Homo sapiens 2.00 0.80 1.20 GN=HSPA2 PE=1 SV=1 IGHG3_HUMAN Ig gamma‐3 chain C region OS=Homo sapiens 2.03 0.82 1.21 GN=IGHG3 PE=1 SV=2 CBPM_HUMAN Carboxypeptidase M OS=Homo sapiens GN=CPM PE=1 1.33 0.13 1.21 SV=2 K2C75_HUMAN Keratin, type II cytoskeletal 75 OS=Homo sapiens 2.00 0.79 1.21 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 GN=KRT75 PE=1 SV=2 ACTBL_HUMAN Beta‐actin‐like protein 2 OS=Homo sapiens 2.71 1.50 1.21 GN=ACTBL2 PE=1 SV=2 PTPRS_HUMAN Receptor‐type tyrosine‐protein phosphatase S 1.50 0.25 1.25 OS=Homo sapiens GN=PTPRS PE=1 SV=2 CYTM_HUMAN Cystatin‐M OS=Homo sapiens GN=CST6 PE=1 SV=1 1.50 0.25 1.25 SDC4_HUMAN Syndecan‐4 OS=Homo sapiens GN=SDC4 PE=1 SV=2 1.33 0.06 1.27 TPIS_HUMAN Triosephosphate isomerase OS=Homo sapiens GN=TPI1 3.00 1.71 1.29 PE=1 SV=2 IGHG1_HUMAN Ig gamma‐1 chain C region OS=Homo sapiens 2.58 1.25 1.33 GN=IGHG1 PE=1 SV=1 TIMD3_HUMAN Hepatitis A virus cellular receptor 2 OS=Homo sapiens 1.67 0.33 1.33 GN=HAVCR2 PE=1 SV=3 KV206_HUMAN Ig kappa chain V‐II region RPMI 6410 OS=Homo 2.33 1.00 1.33 sapiens PE=4 SV=1 RNF26_HUMAN RING finger protein 26 OS=Homo sapiens GN=RNF26 2.34 1.00 1.34 PE=2 SV=1 ANXA2_HUMAN Annexin A2 OS=Homo sapiens GN=ANXA2 PE=1 SV=2 3.00 1.63 1.38 THY1_HUMAN Thy‐1 membrane glycoprotein OS=Homo sapiens 1.67 0.20 1.47 GN=THY1 PE=1 SV=2 AMYP_HUMAN Pancreatic alpha‐amylase OS=Homo sapiens 1.50 0.03 1.47 GN=AMY2A PE=1 SV=2 QPCT_HUMAN Glutaminyl‐peptide cyclotransferase OS=Homo sapiens 1.83 0.33 1.50 GN=QPCT PE=1 SV=1 CEP55_HUMAN Centrosomal protein of 55 kDa OS=Homo sapiens 2.00 0.50 1.50 GN=CEP55 PE=1 SV=3 PCOC1_HUMAN Procollagen C‐endopeptidase enhancer 1 OS=Homo 2.00 0.50 1.50 sapiens GN=PCOLCE PE=1 SV=2 CYTC_HUMAN Cystatin‐C OS=Homo sapiens GN=CST3 PE=1 SV=1 2.00 0.50 1.50 LAMP2_HUMAN Lysosome‐associated membrane glycoprotein 2 2.25 0.75 1.50 OS=Homo sapiens GN=LAMP2 PE=1 SV=2 HSP7C_HUMAN Heat shock cognate 71 kDa protein OS=Homo sapiens 2.50 1.00 1.50 GN=HSPA8 PE=1 SV=1 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 G6PI_HUMAN Glucose‐6‐phosphate isomerase OS=Homo sapiens 4.50 3.00 1.50 GN=GPI PE=1 SV=4 OLFM4_HUMAN Olfactomedin‐4 OS=Homo sapiens GN=OLFM4 PE=1 7.00 5.50 1.50 SV=1 QSOX1_HUMAN Sulfhydryl oxidase 1 OS=Homo sapiens GN=QSOX1 1.67 0.09 1.58 PE=1 SV=3 HV303_HUMAN Ig heavy chain V‐III region VH26 OS=Homo sapiens 2.67 1.00 1.67 PE=1 SV=1 A1AG1_HUMAN Alpha‐1‐acid glycoprotein 1 OS=Homo sapiens 3.00 1.33 1.67 GN=ORM1 PE=1 SV=1 GSTP1_HUMAN Glutathione S‐transferase P OS=Homo sapiens 3.00 1.33 1.67 GN=GSTP1 PE=1 SV=2 AMY2B_HUMAN Alpha‐amylase 2B OS=Homo sapiens GN=AMY2B 1.75 0.03 1.72 PE=1 SV=1 MUC18_HUMAN Cell surface glycoprotein MUC18 OS=Homo sapiens 2.00 0.25 1.75 GN=MCAM PE=1 SV=2 ALBU_HUMAN Serum albumin OS=Homo sapiens GN=ALB PE=1 SV=2 3.38 1.61 1.77 TTHY_HUMAN Transthyretin OS=Homo sapiens GN=TTR PE=1 SV=1 2.78 0.90 1.88 P3IP1_HUMAN Phosphoinositide‐3‐kinase‐interacting protein 1 2.75 0.83 1.92 OS=Homo sapiens GN=PIK3IP1 PE=1 SV=2 ACBP_HUMAN Acyl‐CoA‐binding protein OS=Homo sapiens GN=DBI 3.00 1.00 2.00 PE=1 SV=2 PDXK_HUMAN Pyridoxal kinase OS=Homo sapiens GN=PDXK PE=1 SV=1 3.00 1.00 2.00 PCDH1_HUMAN Protocadherin‐1 OS=Homo sapiens GN=PCDH1 PE=1 3.00 1.00 2.00 SV=2 PSA4_HUMAN Proteasome subunit alpha type‐4 OS=Homo sapiens 3.00 1.00 2.00 GN=PSMA4 PE=1 SV=1 ACAM_HUMAN Adipocyte adhesion molecule OS=Homo sapiens 3.00 1.00 2.00 GN=ACAM PE=1 SV=1 NCAM1_HUMAN Neural cell adhesion molecule 1 OS=Homo sapiens 3.00 1.00 2.00 GN=NCAM1 PE=1 SV=3 TRAK1_HUMAN Trafficking kinesin‐binding protein 1 OS=Homo sapiens 3.00 1.00 2.00 GN=TRAK1 PE=1 SV=1 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 MICA2_HUMAN Protein MICAL‐2 OS=Homo sapiens GN=MICAL2 PE=1 3.00 1.00 2.00 SV=1 XPP2_HUMAN Xaa‐Pro aminopeptidase 2 OS=Homo sapiens 3.00 1.00 2.00 GN=XPNPEP2 PE=1 SV=3 I18BP_HUMAN Interleukin‐18‐binding protein OS=Homo sapiens 3.00 1.00 2.00 GN=IL18BP PE=1 SV=2 FRIH_HUMAN Ferritin heavy chain OS=Homo sapiens GN=FTH1 PE=1 4.00 2.00 2.00 SV=2 FRIL_HUMAN Ferritin light chain OS=Homo sapiens GN=FTL PE=1 SV=2 4.00 2.00 2.00 RALYL_HUMAN RNA‐binding Raly‐like protein OS=Homo sapiens 4.00 2.00 2.00 GN=RALYL PE=1 SV=2 ALDOA_HUMAN Fructose‐bisphosphate aldolase A OS=Homo sapiens 6.00 4.00 2.00 GN=ALDOA PE=1 SV=2 GDIR2_HUMAN Rho GDP‐dissociation inhibitor 2 OS=Homo sapiens 8.00 6.00 2.00 GN=ARHGDIB PE=1 SV=3 TRFE_HUMAN Serotransferrin OS=Homo sapiens GN=TF PE=1 SV=2 4.92 2.86 2.05 LV302_HUMAN Ig lambda chain V‐III region LOI OS=Homo sapiens PE=1 3.00 0.80 2.20 SV=1 ACTB_HUMAN Actin, cytoplasmic 1 OS=Homo sapiens GN=ACTB PE=1 3.68 1.32 2.36 SV=1 ACTG_HUMAN Actin, cytoplasmic 2 OS=Homo sapiens GN=ACTG1 PE=1 3.68 1.32 2.36 SV=1 CYC_HUMAN Cytochrome c OS=Homo sapiens GN=CYCS PE=1 SV=2 3.00 0.60 2.40 KPYM_HUMAN Pyruvate kinase isozymes M1/M2 OS=Homo sapiens 4.00 1.50 2.50 GN=PKM2 PE=1 SV=4 HSP71_HUMAN Heat shock 70 kDa protein 1A/1B OS=Homo sapiens 6.00 3.50 2.50 GN=HSPA1A PE=1 SV=5 GELS_HUMAN Gelsolin OS=Homo sapiens GN=GSN PE=1 SV=1 3.78 1.09 2.69 VMO1_HUMAN Vitelline membrane outer layer protein 1 homolog 3.00 0.29 2.71 OS=Homo sapiens GN=VMO1 PE=1 SV=1 PGRP2_HUMAN N‐acetylmuramoyl‐L‐alanine amidase OS=Homo 3.00 0.20 2.80 sapiens GN=PGLYRP2 PE=1 SV=1 CYTB_HUMAN Cystatin‐B OS=Homo sapiens GN=CSTB PE=1 SV=2 3.67 0.83 2.83 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 ENOA_HUMAN Alpha‐enolase OS=Homo sapiens GN=ENO1 PE=1 SV=2 4.67 1.72 2.94 TPM3_HUMAN Tropomyosin alpha‐3 chain OS=Homo sapiens 4.00 1.00 3.00 GN=TPM3 PE=1 SV=1 DCD_HUMAN Dermcidin OS=Homo sapiens GN=DCD PE=1 SV=2 4.00 1.00 3.00 ARPC3_HUMAN Actin‐related protein 2/3 complex subunit 3 OS=Homo 4.00 1.00 3.00 sapiens GN=ARPC3 PE=1 SV=3 SPRR3_HUMAN Small proline‐rich protein 3 OS=Homo sapiens 4.00 1.00 3.00 GN=SPRR3 PE=1 SV=2 ANR32_HUMAN Ankyrin repeat domain‐containing protein 32 4.00 1.00 3.00 OS=Homo sapiens GN=ANKRD32 PE=1 SV=2 CAPG_HUMAN Macrophage‐capping protein OS=Homo sapiens 5.00 2.00 3.00 GN=CAPG PE=1 SV=1 RET4_HUMAN Retinol‐binding protein 4 OS=Homo sapiens GN=RBP4 3.67 0.42 3.25 PE=1 SV=3 ANT3_HUMAN Antithrombin‐III OS=Homo sapiens GN=SERPINC1 PE=1 5.67 2.29 3.38 SV=1 S10AB_HUMAN Protein S100‐A11 OS=Homo sapiens GN=S100A11 5.00 1.50 3.50 PE=1 SV=2 TPM4_HUMAN Tropomyosin alpha‐4 chain OS=Homo sapiens 4.00 0.33 3.67 GN=TPM4 PE=1 SV=3 CALM_HUMAN Calmodulin OS=Homo sapiens GN=CALM1 PE=1 SV=2 5.00 1.33 3.67 FCG3B_HUMAN Low affinity immunoglobulin gamma Fc region 4.00 0.25 3.75 receptor III‐B OS=Homo sapiens GN=FCGR3B PE=1 SV=2 CO4A_HUMAN Complement C4‐A OS=Homo sapiens GN=C4A PE=1 5.00 1.00 4.00 SV=1 CO4B_HUMAN Complement C4‐B OS=Homo sapiens GN=C4B PE=1 5.00 1.00 4.00 SV=1 NDKA_HUMAN Nucleoside diphosphate kinase A OS=Homo sapiens 5.00 1.00 4.00 GN=NME1 PE=1 SV=1 HBA_HUMAN Hemoglobin subunit alpha OS=Homo sapiens GN=HBA1 5.00 1.00 4.00 PE=1 SV=2 PGAM1_HUMAN Phosphoglycerate mutase 1 OS=Homo sapiens 5.00 0.88 4.13 GN=PGAM1 PE=1 SV=2 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 CMGA_HUMAN Chromogranin‐A OS=Homo sapiens GN=CHGA PE=1 5.50 1.00 4.50 SV=7 CERU_HUMAN Ceruloplasmin OS=Homo sapiens GN=CP PE=1 SV=1 5.61 0.86 4.75 FIBB_HUMAN Fibrinogen beta chain OS=Homo sapiens GN=FGB PE=1 6.00 1.00 5.00 SV=2 1433B_HUMAN 14‐3‐3 protein beta/alpha OS=Homo sapiens 6.00 1.00 5.00 GN=YWHAB PE=1 SV=3 S10A9_HUMAN Protein S100‐A9 OS=Homo sapiens GN=S100A9 PE=1 16.40 11.08 5.32 SV=1 PPIB_HUMAN Peptidyl‐prolyl cis‐trans isomerase B OS=Homo sapiens 8.00 2.00 6.00 GN=PPIB PE=1 SV=2 PRIO_HUMAN Major prion protein OS=Homo sapiens GN=PRNP PE=1 7.00 0.25 6.75 SV=1 1433S_HUMAN 14‐3‐3 protein sigma OS=Homo sapiens GN=SFN PE=1 8.00 1.00 7.00 SV=1 ITIH2_HUMAN Inter‐alpha‐trypsin inhibitor heavy chain H2 OS=Homo 8.00 1.00 7.00 sapiens GN=ITIH2 PE=1 SV=2 NGAL_HUMAN Neutrophil gelatinase‐associated lipocalin OS=Homo 14.33 7.06 7.27 sapiens GN=LCN2 PE=1 SV=2 H4_HUMAN Histone H4 OS=Homo sapiens GN=HIST1H4A PE=1 SV=2 16.00 8.50 7.50 CFAB_HUMAN Complement factor B OS=Homo sapiens GN=CFB PE=1 9.00 0.67 8.33 SV=2 1433E_HUMAN 14‐3‐3 protein epsilon OS=Homo sapiens GN=YWHAE 9.00 0.50 8.50 PE=1 SV=1 CALR_HUMAN Calreticulin OS=Homo sapiens GN=CALR PE=1 SV=1 9.00 0.33 8.67 ILEU_HUMAN Leukocyte elastase inhibitor OS=Homo sapiens 17.00 8.20 8.80 GN=SERPINB1 PE=1 SV=1 FIBG_HUMAN Fibrinogen gamma chain OS=Homo sapiens GN=FGG 12.00 1.00 11.00 PE=1 SV=3 1433Z_HUMAN 14‐3‐3 protein zeta/delta OS=Homo sapiens 13.00 2.00 11.00 GN=YWHAZ PE=1 SV=1 PRTN3_HUMAN Myeloblastin OS=Homo sapiens GN=PRTN3 PE=1 SV=3 26.00 15.00 11.00 ACTN1_HUMAN Alpha‐actinin‐1 OS=Homo sapiens GN=ACTN1 PE=1 22.00 4.67 17.33 © 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021 SV=2 HPT_HUMAN Haptoglobin OS=Homo sapiens GN=HP PE=1 SV=1 21.67 4.00 17.67 ACTN4_HUMAN Alpha‐actinin‐4 OS=Homo sapiens GN=ACTN4 PE=1 21.00 3.00 18.00 SV=2 HSPB1_HUMAN Heat shock protein beta‐1 OS=Homo sapiens 21.00 1.00 20.00 GN=HSPB1 PE=1 SV=2 HPTR_HUMAN Haptoglobin‐related protein OS=Homo sapiens GN=HPR 33.00 1.00 32.00 PE=2 SV=2 INVO_HUMAN Involucrin OS=Homo sapiens GN=IVL PE=1 SV=2 35.00 1.00 34.00 CO3_HUMAN Complement C3 OS=Homo sapiens GN=C3 PE=1 SV=2 42.50 1.92 40.58

© 2013 American Medical Association. All rights reserved.

Downloaded From: https://jamanetwork.com/ on 10/01/2021