Neuromodulation Shapes Interneuron Communication in the Mouse Striatum
From DEPARTMENT OF NEUROSCIENCE Karolinska Institutet, Stockholm, Sweden NEUROMODULATION SHAPES INTERNEURON COMMUNICATION IN THE MOUSE STRIATUM Matthijs Constantijn Dorst Stockholm 2020 All previously published papers were reproduced with permission from the publisher. Published by Karolinska Institutet. Printed by US-AB © Matthijs Constantijn Dorst, 2020 ISBN 978-91-7831-908-4 Neuromodulation shapes interneuron communication in the mouse Striatum THESIS FOR DOCTORAL DEGREE (Ph.D.) By Matthijs Constantijn Dorst Principal Supervisor: Opponent: Professor Gilad Silberberg Professor Hagai Bergman Karolinska Institutet The Hebrew University of Jerusalem Department of Neuroscience Edmond & Lily Safra Center for Brain Sciences Co-supervisor(s): Examination Board: Professor Per Uhlén Professor Per Svenningsson Karolinska Institutet Karolinska Institutet Department of Medical Biochemistry and Department of Clinical Neuroscience Biophysics Division of Neuropharmacology - movement disorders Senior lecturer Karima Chergui Karolinska Institutet Department of Physiology and Pharmacology Division of Molecular Neurophysiology Professor Klas Kullander Uppsala Universitet Department of Neuroscience Research group Formation and Function of Neuronal Circuits Included Studies The following studies are included in this thesis, and will be referenced through- out the text as such: Study 1 Garas, F.N., Shah, R.S., Kormann, E., Doig, N.M., Vinciati, F., Nakamura, K.C., Dorst, M.C., Smith, Y., Magill, P.J. and Sharott, A., 2016. Sec- retagogin expression delineates functionally-specialized populations of striatal parvalbumin-containing interneurons. Elife, 5, p.e16088. Study 2 Lindroos, R., Dorst, M.C., Du, K., Filipović, M., Keller, D., Ketzef, M., Kozlov, A.K., Kumar, A., Lindahl, M., Nair, A.G., Pérez-Fernández, J., Grillner, S., Silberberg, G., Kotaleski, J.H., 2018. Basal Ganglia Neuromodulation Over Multiple Temporal and Structural Scales—Simulations of Direct Pathway MSNs Investigate the Fast Onset of Dopaminergic Effects and Predict the Role of Kv4.
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