Anatomy of the Brainstem
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Pharnygeal Arch Set - Motor USMLE, Limited Edition > Neuroscience > Neuroscience
CNs 5, 7, 9, 10 - Pharnygeal Arch Set - Motor USMLE, Limited Edition > Neuroscience > Neuroscience PHARYNGEAL ARCH SET, CNS 5, 7, 9, 10 • They are derived from the pharyngeal (aka branchial) arches • They have special motor and autonomic motor functions CRANIAL NERVES EXIT FROM THE BRAINSTEM CN 5, the trigeminal nerve exits the mid/lower pons.* CN 7, the facial nerve exits the pontomedullary junction.* CN 9, the glossopharyngeal nerve exits the lateral medulla.* CN 10, the vagus nerve exits the lateral medulla.* CRANIAL NERVE NUCLEI AT BRAINSTEM LEVELS Midbrain • The motor trigeminal nucleus of CN 5. Nerve Path: • The motor division of the trigeminal nerve passes laterally to enter cerebellopontine angle cistern. Pons • The facial nucleus of CN 7. • The superior salivatory nucleus of CN 7. Nerve Path: • CN 7 sweeps over the abducens nucleus as it exits the brainstem laterally in an internal genu, which generates a small bump in the floor of the fourth ventricle: the facial colliculus • Fibers emanate from the superior salivatory nucleus, as well. Medulla • The dorsal motor nucleus of the vagus, CN 10 • The inferior salivatory nucleus, CN 9 1 / 3 • The nucleus ambiguus, CNs 9 and 10. Nerve Paths: • CNs 9 and 10 exit the medulla laterally through the post-olivary sulcus to enter the cerebellomedullary cistern. THE TRIGEMINAL NERVE, CN 5  • The motor division of the trigeminal nerve innervates the muscles of mastication • It passes ventrolaterally through the cerebellopontine angle cistern and exits through foramen ovale as part of the mandibular division (CN 5[3]). Clinical Correlation - Trigeminal Neuropathy THE FACIAL NERVE, CN 7  • The facial nucleus innervates the muscles of facial expression • It spans from the lower pons to the pontomedullary junction. -
Facial Nerve Disorders Cn7 (1)
FACIAL NERVE DISORDERS CN7 (1) Facial Nerve Disorders Last updated: January 18, 2020 FACIAL PALSY .......................................................................................................................................... 1 ETIOLOGY .............................................................................................................................................. 1 GUIDE TO LESION SITE LOCALIZATION ................................................................................................... 2 CLINICAL GRADING OF SEVERITY .......................................................................................................... 2 House-Brackmann grading scale ........................................................................................... 2 CLINICO-ANATOMICAL SYNDROMES ..................................................................................................... 2 Supranuclear (Central) Palsy ................................................................................................. 2 Nuclear Lesion ...................................................................................................................... 3 Cerebellopontine Angle Syndrome ....................................................................................... 3 Facial Canal Syndrome ......................................................................................................... 3 Stylomastoid Foramen Syndrome ........................................................................................ -
The Clinical Treatment and Outcome of Cerebellopontine Angle
www.nature.com/scientificreports OPEN The clinical treatment and outcome of cerebellopontine angle medulloblastoma: a retrospective study of 15 cases Tao Wu 1,4, Pei-ran Qu3,4, Shun Zhang2, Shi-wei Li1, Jing Zhang1, Bo Wang2, Pinan Liu 1,2, Chun-de Li1,2 & Fu Zhao 1,2 ✉ Medulloblastoma (MB) is the most common malignant pediatric brain tumor arising in the cerebellum or the 4th ventricle. Cerebellopontine angle (CPA) MBs are extremely rare tumors, with few cases previously described. In this study, we sought to describe the clinical characteristics, molecular features and outcomes of CPA MB. We retrospectively reviewed a total of 968 patients who had a histopathological diagnosis of MB at the Beijing Neurosurgical Institute between 2002 and 2016. The demographic characteristics, clinical manifestations and radiological features were retrospectively analyzed. Molecular subgroup was evaluated by the expression profling array or immunohistochemistry. Overall survival (OS) and progression-free survival (PFS) were calculated using Kaplan-Meier analysis. In this study, 15 patients (12 adults and 3 children) with a mean age at diagnosis of 25.1 years (range 4–45 years) were included. CPA MBs represented 1.5% of the total cases of MB (15/968). Two molecular subgroups were identifed in CPA MBs: 5 WNT-MBs (33%) and 10 SHH-MBs (67%). CPA WNT-MBs had the extracerebellar growth with the involvement of brainstem (P = 0.002), whereas CPA SHH-MBs predominantly located within the cerebellar hemispheres (P = 0.004). The 5-year OS and PFS rates for CPA MB were 80.0% ± 10.3% and 66.7% ± 12.2%, respectively. -
Auditory and Vestibular Systems Objective • to Learn the Functional
Auditory and Vestibular Systems Objective • To learn the functional organization of the auditory and vestibular systems • To understand how one can use changes in auditory function following injury to localize the site of a lesion • To begin to learn the vestibular pathways, as a prelude to studying motor pathways controlling balance in a later lab. Ch 7 Key Figs: 7-1; 7-2; 7-4; 7-5 Clinical Case #2 Hearing loss and dizziness; CC4-1 Self evaluation • Be able to identify all structures listed in key terms and describe briefly their principal functions • Use neuroanatomy on the web to test your understanding ************************************************************************************** List of media F-5 Vestibular efferent connections The first order neurons of the vestibular system are bipolar cells whose cell bodies are located in the vestibular ganglion in the internal ear (NTA Fig. 7-3). The distal processes of these cells contact the receptor hair cells located within the ampulae of the semicircular canals and the utricle and saccule. The central processes of the bipolar cells constitute the vestibular portion of the vestibulocochlear (VIIIth cranial) nerve. Most of these primary vestibular afferents enter the ipsilateral brain stem inferior to the inferior cerebellar peduncle to terminate in the vestibular nuclear complex, which is located in the medulla and caudal pons. The vestibular nuclear complex (NTA Figs, 7-2, 7-3), which lies in the floor of the fourth ventricle, contains four nuclei: 1) the superior vestibular nucleus; 2) the inferior vestibular nucleus; 3) the lateral vestibular nucleus; and 4) the medial vestibular nucleus. Vestibular nuclei give rise to secondary fibers that project to the cerebellum, certain motor cranial nerve nuclei, the reticular formation, all spinal levels, and the thalamus. -
Lipoma of the Midbrain
LIPOMA OF THE MIDBRAIN POST-MORTEM FINDING IN A PATIENT WITH BREAST CANCER VERÔNICA MAIA GOUVEA * — MYRIAM DUMAS HAHN ** — LEILA CHIMELLI ** SUMMARY — Intracranial lipomas are rare, usually do not have clinical expression and are located mare frequently in the corpus callosum. Other locations include the spinal cord, midbrain tectum, superior vermis, tuber cinereum, infundibulum and more rarely cerebello pontine angle, hypothalamus, superior medullary velum and insula. We report the case of a lipoma of the left inferior colliculus which was a post-mortem finding in a woman who died of breast cancer. Although there are reports of intracranial lipomas in patients with malignant tumors there is no explanation for the co-existence of the two tumors. The present tumor also includes a segment of a nerve which is not uncommon, but a less common finding was the presence of nests of Schwann cells within it, shown by immunohistochemistry. Lipoma do mesencéfalo: achado de necrópsia, em paciente com câncer da mama. RESUMO — Lipomas intracranianos são raros, em geral sem expressão clínica, localizados mais freqüentemente no corpo caloso. Outras localizações incluem medula espinhal, teto mesencefálico, vermis superior, tuber cinereum, infundibulum e mais raramente o ângulo ponto-cerebelar, hipotálamo, véu medular superior e insula. Relatamos o achado de necrópsia de um lipoma do colículo inferior esquerdo em uma mulher com câncer de mama. Embora haja relatos de lipomas intracranianos em pacientes com tumores malignos não há explicação para a co-existência dos dois tumores. O presente tumor também inclui o segmento de um nervo, o que não é incomum, mas um achado menos comum foi a presença de ninhos de células de Schwann no tumor, mostradas por imuno-histoquímica. -
Brainstem and Its Associated Cranial Nerves
Brainstem and its Associated Cranial Nerves Anatomical and Physiological Review By Sara Alenezy With appreciation to Noura AlTawil’s significant efforts Midbrain (Mesencephalon) External Anatomy of Midbrain 1. Crus Cerebri (Also known as Basis Pedunculi or Cerebral Peduncles): Large column of descending “Upper Motor Neuron” fibers that is responsible for movement coordination, which are: a. Frontopontine fibers b. Corticospinal fibers Ventral Surface c. Corticobulbar fibers d. Temporo-pontine fibers 2. Interpeduncular Fossa: Separates the Crus Cerebri from the middle. 3. Nerve: 3rd Cranial Nerve (Oculomotor) emerges from the Interpeduncular fossa. 1. Superior Colliculus: Involved with visual reflexes. Dorsal Surface 2. Inferior Colliculus: Involved with auditory reflexes. 3. Nerve: 4th Cranial Nerve (Trochlear) emerges caudally to the Inferior Colliculus after decussating in the superior medullary velum. Internal Anatomy of Midbrain 1. Superior Colliculus: Nucleus of grey matter that is associated with the Tectospinal Tract (descending) and the Spinotectal Tract (ascending). a. Tectospinal Pathway: turning the head, neck and eyeballs in response to a visual stimuli.1 Level of b. Spinotectal Pathway: turning the head, neck and eyeballs in response to a cutaneous stimuli.2 Superior 2. Oculomotor Nucleus: Situated in the periaqueductal grey matter. Colliculus 3. Red Nucleus: Red mass3 of grey matter situated centrally in the Tegmentum. Involved in motor control (Rubrospinal Tract). 1. Inferior Colliculus: Nucleus of grey matter that is associated with the Tectospinal Tract (descending) and the Spinotectal Tract (ascending). Tectospinal Pathway: turning the head, neck and eyeballs in response to a auditory stimuli. 2. Trochlear Nucleus: Situated in the periaqueductal grey matter. Level of Inferior 3. -
Pilocytic Astrocytoma of the Cerebellopontine Angle in a Child Presenting with Auditory Neuropathy Spectrum Disorder
Otology & Neurotology 00:00Y00 Ó 2014, Otology & Neurotology, Inc. Imaging Case of the Month Pilocytic Astrocytoma of the Cerebellopontine Angle in a Child Presenting With Auditory Neuropathy Spectrum Disorder *Frederike Schneider, *Martin Kompis, †Christoph Ozdoba, ‡Ju¨rgen Beck, *Marco Caversaccio, and *Pascal Senn *University Department of Otorhinolaryngology, Head and Neck Surgery, ÞUniversity Institute of Diagnostic and Interventional Neuroradiology, and þUniversity Department of Neurosurgery, Inselspital, Bern, Switzerland Auditory neuropathy spectrum disorder (ANSD) is a preserved transient evoked OAEs (TEOAEs), and patho- clinical syndrome with hearing loss characterized by logic BERA findings on the left side indicating unilateral measurable otoacoustic emissions (OAEs) and absent or ANSD (Fig. 1). On the right side, all tests were normal abnormal brain stem evoked response audiometry find- (Fig. 1). ings (BERA) (1,2). Routine magnetic resonance imaging The unenhanced, T2-weighted axial images showed a (MRI) has been advocated in children with ANSD be- large, partially cystic, expansive tumor in the cerebello- cause cochlear, neural, or central abnormalities are ob- pontine angle (CPA) on the left side with displacement of served in up to 64% of affected cases (2). In the two the brain stem and the lower Cranial Nerves VII and VIII largest reported imaging series comprising a combined (Fig. 1). Postgadolinium axial and coronal sequences total of 221 children, developmental malformations, such showed strong enhancement of the CPA lesion (Fig. 2). as cochlear nerve deficiency or hindbrain malformations, A retromastoidal craniotomy with subtotal tumor re- were predominantly observed, suggesting a benign origin moval was performed in the neurosurgery department. of ASND in general. Bilateral ANSD cases are approxi- Total resection was not possible because of unclear bor- mately 4 times more frequently associated with intracra- ders between tumor mass and vital brain stem structures. -
Differential Diagnosis and Surgical Management of Cerebellopontine Angle Cystic Lesions Tobias Alécio Mattei, M.D.1 Carlos R
66 Revisão Differential Diagnosis and Surgical Management of Cerebellopontine Angle Cystic Lesions Tobias Alécio Mattei, M.D.1 Carlos R. Goulart, B.S2 Julia Schemes de Lima, B.S.3 Ricardo Ramina, M.D, PhD.4 SUMÁRIO ABSTRACT A maioria dos tumores de ângulo ponto-cerebelar em adultos Cerebellopontine angle (CPA) tumors in adults are mainly são benignos e extra-axiais. A lesão mais comum do ângulo benign and extra-axial. Although the most common CPA lesion ponto-cerebelar (schwannoma vestibular) é familiar à maioria (vestibular schwannoma) is familiar to most neurosurgeons, dos neurocirurgiões. Entretanto lesões císticas do ângulo cystic lesions of the CPA do pose an important diagnostic ponto-cerebelar merecem uma análise cuidadosa, levando-se challenge demanding a careful consideration of a wide em consideração uma ampla gama de diagnósticos diferenciais, range of differential diagnosis including: epidermoid cysts, dentre os quais: cistos epidermóides, cistos aracnóides, arachnoid cysts, cystic schwannomas, cystic meningiomas neurinomas císticos, meningiomas císticos, bem como outras as well as other rare entities such as vascular and malignant entidades mais raras como lesões vasculares e tumorais tumoral lesions. The authors present a critical review of malignas. Os autores apresentam uma revisão critica da the current literature on cystic CPA lesions, providing an literatura, proporcionando ao leitor uma visão geral sobre os overview about possible differentials as well as guidelines for possíveis diagnósticos diferenciais bem como atuais diretrizes preoperative imaging evaluation of a cystic CPA lesion. para a avaliação imagenológica de lesões císticas no ângulo Keywords: Cerebello-pontine angle, epidermoid cysts, ponto-cerebelar. arachnoid cysts, cystic schwannomas, cystic meningiomas, diferencial diagnosis, surgical management. -
Morphometric Assesment of the External Anatomy of Fourth Ventricle and Dorsal Brainstem in Fresh Cadavers
DOI: 10.5137/1019-5149.JTN.24942-18.1 Turk Neurosurg 29(3):445-450, 2019 Received: 26.09.2018 / Accepted: 20.11.2018 Published Online: 19.12.2018 Original Investigation Morphometric Assesment of the External Anatomy of Fourth Ventricle and Dorsal Brainstem in Fresh Cadavers Veysel ANTAR1, Okan TURK1, Salim KATAR2, Mahmut OZDEN3, Balkan SAHIN4, Sahin YUCELI5, Erdogan KARA6, Ayse YURTSEVEN6 1Istanbul Training and Research Hospital, Department of Neurosurgery, Istanbul, Turkey 2Selahattin Eyyubi City Hospital, Department of Neurosurgery, Diyarbakir, Turkey 3Bahcesehir University, Department of Neurosurgery, Istanbul, Turkey 4Sultan Abdulhamit Han Training and Research Hospital, Department of Neurosurgery, Istanbul, Turkey 5Erzincan Neon Hospital, Department of Neurosurgery, Erzincan, Turkey 6Ministry of Justice, Council of Forensic Medicine, Istanbul, Turkey Corresponding author: Veysel ANTAR [email protected] ABSTRACT AIM: To investigate the external anatomy of the fourth ventricle and dorsal brainstem using morphometric data, which could be useful for preoperative surgical planning. MATERIAL and METHODS: Between January 2017 and December 2017, 42 fresh adult cadavers were investigated for the measurements of the cadaver brainstems and fourth ventricle, and they were recorded by photography. Measurements were evaluated according to body mass indexes (BMIs) of the patients. We also investigate the visualization of facial colliculus and stria medullaris on brainstem. RESULTS: A total of 42 fresh cadavers with a mean age of 45.38 ± 16.41 years old were included in this research. We found no statistically significant difference between measurements and BMIs. Facial colliculus was visualized in 92.9% (n=39), but it could not visualized in 7.1% (n=3) of the subjects. -
Cranial Nerve Disorders: Clinical Manifestations and Topographyଝ
Radiología. 2019;61(2):99---123 www.elsevier.es/rx UPDATE IN RADIOLOGY Cranial nerve disorders: Clinical manifestations and topographyଝ a,∗ a b c M. Jorquera Moya , S. Merino Menéndez , J. Porta Etessam , J. Escribano Vera , a M. Yus Fuertes a Sección de Neurorradiología, Hospital Clínico San Carlos, Madrid, Spain b Servicio de Neurología, Hospital Clínico San Carlos, Madrid, Spain c Neurorradiología, Hospital Ruber Internacional, Madrid, Spain Received 17 November 2017; accepted 27 September 2018 KEYWORDS Abstract The detection of pathological conditions related to the twelve cranial pairs rep- Cranial pairs; resents a significant challenge for both clinicians and radiologists; imaging techniques are Cranial nerves; fundamental for the management of many patients with these conditions. In addition to knowl- Cranial neuropathies; edge about the anatomy and pathological entities that can potentially affect the cranial pairs, Neuralgia; the imaging evaluation of patients with possible cranial pair disorders requires specific exami- Cranial nerve palsy nation protocols, acquisition techniques, and image processing. This article provides a review of the most common symptoms and syndromes related with the cranial pairs that might require imaging tests, together with a brief overview of the anatomy, the most common underlying processes, and the most appropriate imaging tests for different indications. © 2018 SERAM. Published by Elsevier Espana,˜ S.L.U. All rights reserved. PALABRAS CLAVE Sintomatología derivada de los pares craneales: Clínica y topografía Pares craneales; Resumen La detección de la patología relacionada con los doce pares craneales representa Nervios craneales; un importante desafío, tanto para los clínicos como para los radiólogos. Las técnicas de imagen Neuropatía de pares craneales; son fundamentales para el manejo de muchos de los pacientes. -
Seventh-And-A-Half Syndrome
Ophthalmology And Ophthalmic Surgery Open Access Case Report Seventh-and-a-Half Syndrome Ama Sadaka*, Shauna Berry and Andrew G Lee Department of Ophthalmology, Blanton Eye Institute, the Methodist Hospital, USA A R T I C L E I N F O A B S T R A C T Article history: Received: 04 September 2017 This is a case of a patient with right internuclear ophthalmoplegia and right Accepted: 05 October 2017 Published: 13 October 2017 peripheral seventh nerve palsy with no other neurologic deficits. Magnetic Keywords: resonance imaging showed a small localized right hemipons infarct involving Seven-and-a-half syndrome; INO facial motor nucleus and facial genu as well as the right medial longitudinal fasciculus. We introduce “Seven-and-a-half syndrome” as a new Copyright: ©2017 Sadaka A clinicoradiologic syndrome. Ophthalmol Ophthalmic Surg This is an open access article distributed Case Presentation under the Creative Commons Attribution License, which permits unrestricted use, A 68-year-old white female presented with sudden onset horizontal binocular distribution, and reproduction in any medium, provided the original work is diplopia and right-sided facial weakness involving the upper and lower face properly cited. consistent with a severe lower motor neuron seventh nerve palsy. Past medical Citation this article: Sadaka A, Berry S, Lee AG. Seventh-and-a-Half Syndrome. history was significant for uncontrolled hypertension and cerebral amyloid Ophthalmol Ophthalmic Surg. 2017; 1(1):112. angiopathy. No history of head trauma or infection. Visual acuity was 20/20 in both eyes. Pupils were equal and reactive with no relative afferent pupillary defect in either eye. -
Inter-And Intrapatient Variability of Facial Nerve Response Areas in The
http://www.ncbi.nlm.nih.gov/pubmed/21206320. Postprint available at: http://www.zora.uzh.ch Posted at the Zurich Open Repository and Archive, University of Zurich. University of Zurich http://www.zora.uzh.ch Zurich Open Repository and Archive Originally published at: Bertalanffy, H; Tissira, N; Krayenbühl, N; Bozinov, O; Sarnthein , J (2011). Inter- and intrapatient variability of facial nerve response areas in the floor of the fourth ventricle. Neurosurgery, 68(1 Supp):23-31. Winterthurerstr. 190 CH-8057 Zurich http://www.zora.uzh.ch Year: 2011 Inter- and intrapatient variability of facial nerve response areas in the floor of the fourth ventricle Bertalanffy, H; Tissira, N; Krayenbühl, N; Bozinov, O; Sarnthein , J http://www.ncbi.nlm.nih.gov/pubmed/21206320. Postprint available at: http://www.zora.uzh.ch Posted at the Zurich Open Repository and Archive, University of Zurich. http://www.zora.uzh.ch Originally published at: Bertalanffy, H; Tissira, N; Krayenbühl, N; Bozinov, O; Sarnthein , J (2011). Inter- and intrapatient variability of facial nerve response areas in the floor of the fourth ventricle. Neurosurgery, 68(1 Supp):23-31. Inter- and intrapatient variability of facial nerve response areas in the floor of the fourth ventricle Abstract BACKGROUND: Surgical exposure of intrinsic brainstem lesions through the floor of the 4th ventricle requires precise identification of facial nerve (CN VII) fibers to avoid damage. OBJECTIVE: To assess the shape, size, and variability of the area where the facial nerve can be stimulated electrophysiologically on the surface of the rhomboid fossa. METHODS: Over a period of 18 months, 20 patients were operated on for various brainstem and/or cerebellar lesions.