Brainstem: Structure & Func On

Total Page:16

File Type:pdf, Size:1020Kb

Brainstem: Structure & Func On Brainstem: Structure & Func1on Adrian Poniatowski StudyAid Neuroanatomy Seminar November 26, 2017 A pleasure to meet you... • Name: Adrian Poniatowski • Hometown: New York City • Job: Professional Baller, Future Doctor • Hobbies: Winning @ Life Brainstem = Manha<an • Connects everything • Every connecon is important • Small lesions = big problems • Locaon, locaon, locaon! Ques1on 1 Cranial nerves exit from the following locaons EXCEPT • a.) vagus nerve from posterior lateral sulcus • b.) facial nerve from cerebello-ponne angle • c.) abducens nerve from anterior lateral sulcus • d.) trochlear nerve lateral to the frenulum of the superior medullary velum • e.) oculomotor nerve from interpeduncular fossa 3 Midbrain Pons Cross-secons: Clinical Correlates Medulla Ques1on 2 All of the following locaons given are correct EXCEPT: • a.) motor nucleus of trigeminal - ponne tegmentum • b.) superior salivatory nucleus of VII - ponne tegmentum • c.) superior vesMbular nucleus of VIII - ponne tegmentum • d.) motor nucleus of hypoglossal - dorsal medulla • e.) motor nucleus of VI - mesencephalic tegmentum MLF Pathway • FuncMon: Connects oculomotor nuclei to integrate eye movements • Nerves: CN III and VI • Lesion causes Internuclear Opthalmoplegia • Abnormal adducMon of IPSILATERAL eye, usually with nystagmus • Where is the lesion here? Ques1on 3 Muscles of the eyeball are innervated by all of the following EXCEPT: • a.) axons of the nucleus located in the mesencephalic tegmentum • b.) axons of the nucleus located in the ponne tegmentum • c.) axons of the nucleus located in the dorsal medulla • d.) axons of the superior cervical ganglion • e.) axons of the ciliary gangilion Ques1on 4 • Which of the following is NOT located in rhomboid fossa? • a.) medial eminence • b.) cuneate tubercle • c.) facial colliculus • d.) locus ceruleus • e.) hypoglossal triangle Cor1cobulbar Tract Cor1cobulbar Tract Cor1cobulbar Tract • Pathway: Primary motor corMces - internal capsule - crus cerebri – X- CN nuclei in dorsal pons • Nerves: Brainstem LMN • FuncMon: Regulaon of brainstem acMvity Bell’s Palsy • It looks far worse than it is • Central vs. peripheral lesion • CN VII • Principal of contralateral and ipsilateral MOTOR input Ques1on 5 Tracts which control voluntary movement of muscles of facial expression are characterized by all of the following EXCEPT: • a.) They arise from the postcentral gyrus • b.) they traverse genu of the internal capsule • c.) they traverse crus cerebri • d.) they reach contralateral motor nucleus • e.) they reach dorsal pons (ponne tegmentum) Solitary Tract • Pathways: Gustatory, Swallowing, Vagal Pathways • Nerves: inferior ganglion of CN X, geniculate ganglion of CN VII, and CN IX • Solitary nucleus originates in medulla .
Recommended publications
  • The Interpeduncular Fossa Approach for Resection of Ventromedial Midbrain Lesions
    TECHNICAL NOTE J Neurosurg 128:834–839, 2018 The interpeduncular fossa approach for resection of ventromedial midbrain lesions *M. Yashar S. Kalani, MD, PhD, Kaan Yağmurlu, MD, and Robert F. Spetzler, MD Department of Neurosurgery, Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, Phoenix, Arizona The authors describe the interpeduncular fossa safe entry zone as a route for resection of ventromedial midbrain le- sions. To illustrate the utility of this novel safe entry zone, the authors provide clinical data from 2 patients who under- went contralateral orbitozygomatic transinterpeduncular fossa approaches to deep cavernous malformations located medial to the oculomotor nerve (cranial nerve [CN] III). These cases are supplemented by anatomical information from 6 formalin-fixed adult human brainstems and 4 silicone-injected adult human cadaveric heads on which the fiber dissection technique was used. The interpeduncular fossa may be incised to resect anteriorly located lesions that are medial to the oculomotor nerve and can serve as an alternative to the anterior mesencephalic safe entry zone (i.e., perioculomotor safe entry zone) for resection of ventromedial midbrain lesions. The interpeduncular fossa safe entry zone is best approached using a modi- fied orbitozygomatic craniotomy and uses the space between the mammillary bodies and the top of the basilar artery to gain access to ventromedial lesions located in the ventral mesencephalon and medial to the oculomotor nerve. https://thejns.org/doi/abs/10.3171/2016.9.JNS161680 KEY WORDS brainstem surgery; interpeduncular fossa; mesencephalon; safe entry zone; surgical technique; ventromedial midbrain HE human brainstem serves as a relay center for the pyramidal tract, which is located in the middle three- ascending and descending fiber tracts that are es- fifths of the cerebral peduncle, to remove ventral lesions sential for motor and sensory control.
    [Show full text]
  • Auditory and Vestibular Systems Objective • to Learn the Functional
    Auditory and Vestibular Systems Objective • To learn the functional organization of the auditory and vestibular systems • To understand how one can use changes in auditory function following injury to localize the site of a lesion • To begin to learn the vestibular pathways, as a prelude to studying motor pathways controlling balance in a later lab. Ch 7 Key Figs: 7-1; 7-2; 7-4; 7-5 Clinical Case #2 Hearing loss and dizziness; CC4-1 Self evaluation • Be able to identify all structures listed in key terms and describe briefly their principal functions • Use neuroanatomy on the web to test your understanding ************************************************************************************** List of media F-5 Vestibular efferent connections The first order neurons of the vestibular system are bipolar cells whose cell bodies are located in the vestibular ganglion in the internal ear (NTA Fig. 7-3). The distal processes of these cells contact the receptor hair cells located within the ampulae of the semicircular canals and the utricle and saccule. The central processes of the bipolar cells constitute the vestibular portion of the vestibulocochlear (VIIIth cranial) nerve. Most of these primary vestibular afferents enter the ipsilateral brain stem inferior to the inferior cerebellar peduncle to terminate in the vestibular nuclear complex, which is located in the medulla and caudal pons. The vestibular nuclear complex (NTA Figs, 7-2, 7-3), which lies in the floor of the fourth ventricle, contains four nuclei: 1) the superior vestibular nucleus; 2) the inferior vestibular nucleus; 3) the lateral vestibular nucleus; and 4) the medial vestibular nucleus. Vestibular nuclei give rise to secondary fibers that project to the cerebellum, certain motor cranial nerve nuclei, the reticular formation, all spinal levels, and the thalamus.
    [Show full text]
  • Central Neurocircuits Regulating Food Intake in Response to Gut Inputs—Preclinical Evidence
    nutrients Review Central Neurocircuits Regulating Food Intake in Response to Gut Inputs—Preclinical Evidence Kirsteen N. Browning * and Kaitlin E. Carson Department of Neural and Behavioral Sciences, Penn State College of Medicine, Hershey, PA 17033, USA; [email protected] * Correspondence: [email protected]; Tel.: +1-717-531-8267 Abstract: The regulation of energy balance requires the complex integration of homeostatic and hedonic pathways, but sensory inputs from the gastrointestinal (GI) tract are increasingly recognized as playing critical roles. The stomach and small intestine relay sensory information to the central nervous system (CNS) via the sensory afferent vagus nerve. This vast volume of complex sensory information is received by neurons of the nucleus of the tractus solitarius (NTS) and is integrated with responses to circulating factors as well as descending inputs from the brainstem, midbrain, and forebrain nuclei involved in autonomic regulation. The integrated signal is relayed to the adjacent dorsal motor nucleus of the vagus (DMV), which supplies the motor output response via the efferent vagus nerve to regulate and modulate gastric motility, tone, secretion, and emptying, as well as intestinal motility and transit; the precise coordination of these responses is essential for the control of meal size, meal termination, and nutrient absorption. The interconnectivity of the NTS implies that many other CNS areas are capable of modulating vagal efferent output, emphasized by the many CNS disorders associated with dysregulated GI functions including feeding. This review will summarize the role of major CNS centers to gut-related inputs in the regulation of gastric function Citation: Browning, K.N.; Carson, with specific reference to the regulation of food intake.
    [Show full text]
  • Anatomy of the Brainstem
    Anatomy of the Brainstem Neuroanatomy block-Anatomy-Lecture 5 Editing file Objectives At the end of the lecture, students should be able to: 01 List the components of brain stem. 02 Describe the site of brain stem 03 Describe the relations between components of brain stem & their relations to cerebellum. 04 Describe the external features of both ventral & dorsal surfaces of brain stem Color guide 05 List cranial nerves emerging from brain stem 06 Describe the site of emergence of each cranial nerve ● Only in boys slides in Green ● Only in girls slides in Purple ● important in Red ● Notes in Grey Development of Brain Brain stem ● The brain develops from the cranial part of neural tube. ● The brainstem is the region of the brain that connects the ● The cranial part is divided into 3 parts: cerebrum with the spinal cord. ● Site: It lies on the basilar part of occipital bone (clivus). - Subdivided into: ● Parts from above downwards : 1. Telencephalon: (cavities: 2 lateral ventricles) 1. Midbrain Two cerebral hemispheres. Forebrain 2. Pons 2. Diencephalon: (cavity: 3rd ventricle) 3. Medulla oblongata thalamus, hypothalamus, epithalamus & subthalamus ● Connection with cerebellum: Each part of the brain stem is connected to the Midbrain - (cavity: cerebral aqueduct) cerebellum by cerebellar peduncles (superior, middle & inferior). - (cavity: 4th ventricle) - Subdivided into: Hindbrain 1. Pons 2. Cerebellum 3. Medulla oblongata 3 Sagittal section of Brain 4 Functions of the Brain Stem Pathway of tracts between cerebral cortex & spinal cord (ascending and descending tracts). 1 Site of origin of nuclei of cranial nerves (from 3rd to 12th). 2 Site of emergence of cranial nerves (from 3rd to 12th).
    [Show full text]
  • Brainstem and Its Associated Cranial Nerves
    Brainstem and its Associated Cranial Nerves Anatomical and Physiological Review By Sara Alenezy With appreciation to Noura AlTawil’s significant efforts Midbrain (Mesencephalon) External Anatomy of Midbrain 1. Crus Cerebri (Also known as Basis Pedunculi or Cerebral Peduncles): Large column of descending ​ “Upper Motor Neuron” fibers that is responsible for movement coordination, which are: a. Frontopontine fibers b. Corticospinal fibers Ventral Surface c. Corticobulbar fibers d. Temporo-pontine fibers 2. Interpeduncular Fossa: Separates the Crus Cerebri from the middle. ​ 3. Nerve: 3rd Cranial Nerve (Oculomotor) emerges from the Interpeduncular fossa. ​ 1. Superior Colliculus: Involved with visual reflexes. ​ ​ ​ ​ Dorsal Surface 2. Inferior Colliculus: Involved with auditory reflexes. ​ ​ ​ 3. Nerve: 4th Cranial Nerve (Trochlear) emerges caudally to the Inferior Colliculus after decussating in the ​ superior medullary velum. Internal Anatomy of Midbrain 1. Superior Colliculus: Nucleus of grey matter that is associated with the Tectospinal Tract (descending) and the Spinotectal Tract ​ (ascending). a. Tectospinal Pathway: turning the head, neck and eyeballs in response to a visual stimuli.1 Level of ​ ​ ​ b. Spinotectal Pathway: turning the head, neck and eyeballs in response to a cutaneous stimuli.2 Superior ​ ​ ​ ​ 2. Oculomotor Nucleus: Situated in the periaqueductal grey matter. Colliculus ​ 3. Red Nucleus: Red mass3 of grey matter situated centrally in the Tegmentum. Involved in motor control (Rubrospinal Tract). ​ 1. Inferior Colliculus: Nucleus of grey matter that is associated with the Tectospinal Tract (descending) and the Spinotectal Tract ​ (ascending). Tectospinal Pathway: turning the head, neck and eyeballs in response to a auditory stimuli. ​ ​ ​ ​ 2. Trochlear Nucleus: Situated in the periaqueductal grey matter. Level of ​ Inferior 3.
    [Show full text]
  • The Oculomotor Cistern: Anatomy and High- ORIGINAL RESEARCH Resolution Imaging
    The Oculomotor Cistern: Anatomy and High- ORIGINAL RESEARCH Resolution Imaging K.L. Everton BACKGROUND AND PURPOSE: The oculomotor cistern (OMC) is a small CSF-filled dural cuff that U.A. Rassner invaginates into the cavernous sinus, surrounding the third cranial nerve (CNIII). It is used by neuro- surgeons to mobilize CNIII during cavernous sinus surgery. In this article, we present the OMC imaging A.G. Osborn spectrum as delineated on 1.5T and 3T MR images and demonstrate its involvement in cavernous H.R. Harnsberger sinus pathology. MATERIALS AND METHODS: We examined 78 high-resolution screening MR images of the internal auditory canals (IAC) obtained for sensorineural hearing loss. Cistern length and diameter were measured. Fifty randomly selected whole-brain MR images were evaluated to determine how often the OMC can be visualized on routine scans. Three volunteers underwent dedicated noncontrast high-resolution MR imaging for optimal OMC visualization. RESULTS: One or both OMCs were visualized on 75% of IAC screening studies. The right cistern length averaged 4.2 Ϯ 3.2 mm; the opening diameter (the porus) averaged 2.2 Ϯ 0.8 mm. The maximal length observed was 13.1 mm. The left cistern length averaged 3.0 Ϯ 1.7 mm; the porus diameter averaged 2.1 Ϯ1.0 mm, with a maximal length of 5.9 mm. The OMC was visualized on 64% of routine axial T2-weighted brain scans. CONCLUSION: The OMC is an important neuroradiologic and surgical landmark, which can be routinely identified on dedicated thin-section high-resolution MR images. It can also be identified on nearly two thirds of standard whole-brain MR images.
    [Show full text]
  • Lateral Hypothalamic Modulation of the Gustatory-Salivary Reflex in Rats’
    0270.6474/84/0405-1208$02.00/O The Journal of Neuroscience Copyright 0 Society for Neuroscience Vol. 4, No. 5, pp. 1208-1216 Printed in U.S.A. May 1984 LATERAL HYPOTHALAMIC MODULATION OF THE GUSTATORY-SALIVARY REFLEX IN RATS’ RYUJI MATSU02 AND KIYOSHI KUSAN03 Neurophysiology Laboratory, Department of Biology, Illinois Institute of Technology, Chicago, Illinois 60616 Received June 27, 1983; Revised November 29, 1983; Accepted January 3, 1984 Abstract It is well recognized that the basic mechanism for the gustatory-salivary reflex is located in the lower brainstem and that suprabulbar structures possibly influence this mechanism. This study is designed to evaluate the neurophysiological mechanism underlying the effect of the lateral hypo- thalamic area (LHA) on the bulbar gustatory-salivary reflex. Submandibular salivary secretion and the electrical activity of the preganglionic parasympathetic fibers innervating the submandibular and sublingual glands were recorded in anesthetized rats. Stimulation of the tongue with high concentrations of chemical solutions (1 M and 2 M NaCl and 0.01 M and 0.05 M HCl) and/or pinching the tongue with a small clamp induced a profuse salivary secretion (3 to 28.5 ~1/5 min) recorded from a unilateral submandibular gland. The preganglionic fibers consisted of three types: taste-related fibers, which increased their firing rate by taste stimuli; pinch-related fibers, which increased their firing rate by pinching; and unidentified fibers, which did not respond to taste or pinching stimulations of the tongue. Electrical stimulation of the ipsilateral LHA caused the secretion of a small amount of saliva (1.5 ~1/5 min), and it appeared that taste-related fibers more often received polysynaptic connections from the LHA than other types of fibers.
    [Show full text]
  • Morphometric Assesment of the External Anatomy of Fourth Ventricle and Dorsal Brainstem in Fresh Cadavers
    DOI: 10.5137/1019-5149.JTN.24942-18.1 Turk Neurosurg 29(3):445-450, 2019 Received: 26.09.2018 / Accepted: 20.11.2018 Published Online: 19.12.2018 Original Investigation Morphometric Assesment of the External Anatomy of Fourth Ventricle and Dorsal Brainstem in Fresh Cadavers Veysel ANTAR1, Okan TURK1, Salim KATAR2, Mahmut OZDEN3, Balkan SAHIN4, Sahin YUCELI5, Erdogan KARA6, Ayse YURTSEVEN6 1Istanbul Training and Research Hospital, Department of Neurosurgery, Istanbul, Turkey 2Selahattin Eyyubi City Hospital, Department of Neurosurgery, Diyarbakir, Turkey 3Bahcesehir University, Department of Neurosurgery, Istanbul, Turkey 4Sultan Abdulhamit Han Training and Research Hospital, Department of Neurosurgery, Istanbul, Turkey 5Erzincan Neon Hospital, Department of Neurosurgery, Erzincan, Turkey 6Ministry of Justice, Council of Forensic Medicine, Istanbul, Turkey Corresponding author: Veysel ANTAR [email protected] ABSTRACT AIM: To investigate the external anatomy of the fourth ventricle and dorsal brainstem using morphometric data, which could be useful for preoperative surgical planning. MATERIAL and METHODS: Between January 2017 and December 2017, 42 fresh adult cadavers were investigated for the measurements of the cadaver brainstems and fourth ventricle, and they were recorded by photography. Measurements were evaluated according to body mass indexes (BMIs) of the patients. We also investigate the visualization of facial colliculus and stria medullaris on brainstem. RESULTS: A total of 42 fresh cadavers with a mean age of 45.38 ± 16.41 years old were included in this research. We found no statistically significant difference between measurements and BMIs. Facial colliculus was visualized in 92.9% (n=39), but it could not visualized in 7.1% (n=3) of the subjects.
    [Show full text]
  • Lecture (6) Internal Structures of the Brainstem.Pdf
    Internal structures of the Brainstem Neuroanatomy block-Anatomy-Lecture 6 Editing file Objectives At the end of the lecture, students should be able to: ● Distinguish the internal structure of the components of the brain stem in different levels and the specific criteria of each level. 1. Medulla oblongata (closed, mid and open medulla) 2. Pons (caudal and rostral). 3. Midbrain ( superior and inferior colliculi). Color guide ● Only in boys slides in Green ● Only in girls slides in Purple ● important in Red ● Notes in Grey Medulla oblongata Caudal (Closed) Medulla Traversed by the central canal Motor decussation (decussation of the pyramids) ● Formed by pyramidal fibers, (75-90%) cross to the opposite side ● They descend in the lateral white column of the spinal cord as the lateral corticospinal tract. ● The uncrossed fibers form the ventral corticospinal tract Trigeminal sensory nucleus. ● it is the larger sensory nucleus. ● The Nucleus Extends Through the whole length of the brainstem and its note :All CN V afferent sensory information enters continuation of the substantia gelatinosa of the spinal cord. the brainstem through the nerve itself located in the pons. Thus, to reach the spinal nucleus (which ● It lies in all levels of M.O, medial to the spinal tract of the trigeminal. spans the entire brain stem length) in the Caudal ● It receives pain and temperature from face, forehead. Medulla those fibers have to "descend" in what's known as the Spinal Tract of the Trigeminal ● Its tract present in all levels of M.O. is formed of descending (how its sensory and descend?see the note) fibers that terminate in the trigeminal nucleus.
    [Show full text]
  • Prenatal Development Timeline
    Prenatal Development Timeline Nervous Cardiovascular Muscular Early Events Special Senses Respiratory Skeletal Growth Parameters Blood & Immune Gastrointestinal Endocrine General Skin/Integument Renal/Urinary Reproductive Movement Unit 1: The First Week Day 0 — — Embryonic period begins Fertilization resulting in zygote formation Day 1 — — Embryo is spherically shaped and called a morula comprised of 12 to 16 blastomeres Embryo is spherically shaped with 12 to 16 cells Day 1 - Day 1 — — Fertilization - development begins with a single-cell embryo!!! Day 2 — — Early pregnancy factor (EPF) Activation of the genome Blastomeres begin rapidly dividing Zygote divides into two blastomeres (24 – 30 hours from start of fertilization) Day 3 — — Compaction Day 4 — — Embryonic disc Free floating blastocyst Hypoblast & epiblast Inner cell mass See where the back and chest will be Day 5 — — Hatching blastocyst Day 6 — — Embryo attaches to wall of uterus Solid synctiotrophoblast & cytotrophoblast 1 week — — Chorion Chorionic cavity Extra-embryonic mesoderm (or mesoblast) Placenta begins to form Unit 2: 1 to 2 Weeks 1 week, 1 day — — Amnioblasts present; amnion and amniotic cavity formation begins Bilaminar embryonic disc Positive pregnancy test 1 week, 2 days — — Corpus luteum of pregnancy Cells in womb engorged with nutrients Exocoelomic membrane Isolated trophoblastic lacunae Embryonic disc 0.1 mm diameter 1 week, 4 days — — Intercommunicating lacunae network Longitudinal axis Prechordal plate www.ehd.org 1 of 33 Trophoblastic vascular circle 1 week,
    [Show full text]
  • Interpeduncular Heterotopia in Joubert Syndrome: a Previously
    Interpeduncular Heterotopia in Joubert Syndrome: CLINICAL REPORT A Previously Undescribed MR Finding I. Harting SUMMARY: The so-called molar tooth sign is the radiologic hallmark of JSRD. Joubert syndrome is a U. Kotzaeridou rare, most often autosomal-recessive disorder with a characteristic malformation of the midhindbrain. We describe 3 patients with JSRD and the additional MR finding of tissue resembling heterotopia in A. Poretti the interpeduncular fossa, which in one patient was combined with a more extensive intramesen- A. Seitz cephalic heterotopia. Interpeduncular heterotopia has not been reported previously, either in the J. Pietz context of JSRD or as a separate entity. This new imaging feature enlarges the spectrum of brain stem M. Bendszus abnormalities in JSRD. In view of the underlying ciliopathy, it seems likely that the interpeduncular E. Boltshauser heterotopia results from misdirected migration. ABBREVIATIONS: CNS ϭ central nervous system; GE ϭ gradient-echo; JSRD ϭ Joubert syndrome and related disorders; T1WI, T1-weighted imaging; T2WI ϭ T2-weighted imaging oubert syndrome is a rare disorder (estimated prevalence truncal control had significantly improved, and her respira- J1/100 000) with a characteristic complex malformation of tion normalized. Neurologic examination revealed persisting the midbrain-hindbrain, seen as the so-called molar tooth sign profound muscular hypotonia and lack of spontaneous move- on axial imaging. This results from vermis hypoplasia, a deep ments, horizontal nystagmus, and lack of fixation due to se- interpeduncular fossa and thickened, elongated, abnormally verely reduced visual acuity. horizontal superior cerebellar peduncles.1 Joubert syndrome In addition to the characteristic molar tooth sign, MR im- is clinically characterized by cognitive impairment, hypotonia, aging revealed a circumscribed, nodular structure within the and later evolving ataxia.
    [Show full text]
  • Seventh-And-A-Half Syndrome
    Ophthalmology And Ophthalmic Surgery Open Access Case Report Seventh-and-a-Half Syndrome Ama Sadaka*, Shauna Berry and Andrew G Lee Department of Ophthalmology, Blanton Eye Institute, the Methodist Hospital, USA A R T I C L E I N F O A B S T R A C T Article history: Received: 04 September 2017 This is a case of a patient with right internuclear ophthalmoplegia and right Accepted: 05 October 2017 Published: 13 October 2017 peripheral seventh nerve palsy with no other neurologic deficits. Magnetic Keywords: resonance imaging showed a small localized right hemipons infarct involving Seven-and-a-half syndrome; INO facial motor nucleus and facial genu as well as the right medial longitudinal fasciculus. We introduce “Seven-and-a-half syndrome” as a new Copyright: ©2017 Sadaka A clinicoradiologic syndrome. Ophthalmol Ophthalmic Surg This is an open access article distributed Case Presentation under the Creative Commons Attribution License, which permits unrestricted use, A 68-year-old white female presented with sudden onset horizontal binocular distribution, and reproduction in any medium, provided the original work is diplopia and right-sided facial weakness involving the upper and lower face properly cited. consistent with a severe lower motor neuron seventh nerve palsy. Past medical Citation this article: Sadaka A, Berry S, Lee AG. Seventh-and-a-Half Syndrome. history was significant for uncontrolled hypertension and cerebral amyloid Ophthalmol Ophthalmic Surg. 2017; 1(1):112. angiopathy. No history of head trauma or infection. Visual acuity was 20/20 in both eyes. Pupils were equal and reactive with no relative afferent pupillary defect in either eye.
    [Show full text]