The Newsletter of the NIH Alumni Association

Summer 2002 Vol. 14, No. 2 date Zerhouni Selected 15th Briefings on Bioterrorism, Award Presentation to NIH Director Fredrickson at 2002 NIHAA Annual Meeting By Rich McManus The reality of the nation's concern with terrorism was brought home to Dr. Elias Zerhouni (pronounced eh­ those who attended NlHAA's annual LEE-as zer-800-nee) was confirmed, meeting on June 1. The principal pro­ by unanimous voice vote of the U.S. gram presentation was an authoritative Senate on May 2, to become 15th ctirec­ briefing on bioterrorism, and t11e venue tor of the National Institutes of Health. of the meeting itself was in part deter­ Two days earlier, at a 75-minute confir­ mined by anti-terrorism measures. The mation hearing before the Senate com­ Cloister, site of previous meetings, is mittee on health, education, labor, and within the NIH secu1ity perimeter. Its pensions chaired by Sen.Ted Kennedy use for the Saturday session was not (which also voted unanimously to con­ feasible. However, the nearby fllm), Zerhouni offered a preliminary vi­ Bethesda United Methodist Church sion of his µJans for NIH, which in­ provided a welcome and comfortable clude relying not only on the creative meeting hall with parking for about 7~ spark of the individual scientist, but members and guests who attended the also on a "new science" approach em­ meeting. Dr. Donald S. Fredrickson- 11th NIH Director phasizing multidisciplinary teams work­ ing in concert. (See Annual Meeting, p. 11) A successful administrator, entrepre­ neur, basic scientist and clinician him­ Zerhouni Welcomed, Kirschstein Applauded at self during more tban a guarter century 84th ACD Meeting on June 6 at Johns Hopkins University School of Medicine, Zerhouni, who appeared By Carla Garnett with his mother, bis wife Nadia and three children, as well as with a friend Just moments after 8:30 a.m. on June 6 business executives that assembles on (See Zerhowii, p.12) and a scant 2 weeks after his first day campus to consider the NIH enterprise on the job,new NIH director Dr. Elias every June and December. Zerhouni was formally handed the (See ACD, p. 14) gavel at the 84'11 meeting of the advi­ sory committee to the director (ACD), In This Issue Page which he now chairs as head of the Dr. Donald Kennedy to deliver sixth 2 agency. James A. Shannon lecture "I think we should have a ceremony Research Festival 2002 schedule 3 that allows Dr. Zerhouni's previous Calendar of exhibits and events 5 home institution to tum the gavel over News from and about NIHAA members 6 to our new chairman," said NIH deputy director Dr. Ruth Kirschstein, who had Safra Founda1ion supports family lodge J 6 chaired the twice-yearly ACD meetings NlH haven from antinepotism rules 18 as acting NIH director since 2000. She Bioterrorism at NJl:I 20 calledonA CD member Dr. William FYI 22 Brody, president of Johns Hopkins Uni­ NIH notes 24 versity, to introduce Zerhouni to the Dr. Donald S. Fredrickson (1924-2002) 30 Dr. Elias Zerhouni · 15th NIH Director 36-year-old gathering of physicians, re­ NIH retrospective 31 searchers, lawyers, professors and N I H A A U P D A T E

Dr. Donald Kennedy To Give Sixth Shannon Lecture

On Wednesday, Nov. 20, 2002, Dr. Drug and Cosmetics Act i:n the pro­ Donald Kennedy, foaner FDA commis­ posed Drug Regulation Reform Act of Update sioner (1977-1979), former president of 1978, and conducted amajorrevision of The NIHAA Update is the newsletter ofthe Stanford University, and now editor of many of the agency's manufacturing NIH AlumniAssociation. The NIHAA office is Science magazine, will deliver the sixth practices. He left in June 1979 and re­ at 9101 Old Georgetown Rd., Bethesda, MD James A. Shannon Lecture at 3 p.m. in turned to Stanford, where he was vice 20814-1616, 301-530-0567; email address: Masur Auditorium, Bldg. 10. He will president for academic affairs and pro­ [email protected]; we/Jsile: wwwfnih. speak on "A Second Postwar Revolu­ vost and then, from 1980 to 1991, presi­ org!nihaa. .htm l. tion in Biomedicine." dent of the university. Editor's Note Kennedy is an intemationally recognized In 1992, Kennedy returned to the neurophysiologist who was born in New Stanford faculty as Bing professor of en­ The ND-IAA Update welcomes letters and Yorlcin 1931. He pursued both his under­ vironmental sciences. He was named in news from its re(J.(/ers. We wish to provide graduate and graduate education at Harvard June 2000 editor of Science. The many news about NIH to its alumni and to report alumni concerns and informatio~ppoint­ receiving a Ph.D. inbiological sciences in recognitions he has received include hon­ ments, honors, publications and other interest­ 1956. Following a 4-yearpeiiod on thefac­ orary degrees from Columbia, Rochester, ing developments--10 their colleagues. If you ulty of Syracuse University, he moved in Michigan and Arizona universitie.c; and have news about yourself or other alumni or 1960 to thedepaitment ofbiological sci­ membership in the National Academy of comments/suggestions for the N1HAA Up­ ences at Stanford, the institution where he Sciences. date, please drop a note to the editor. We has spent the restof bis academic career. In 1997, the NIHAA established a reserve the right to edit materia_ls. His broad interests include comparative lecture series named in honor of Dr. Editor: Harriet R. Greenwald mruine biology, public policy, nutrition and James A. Shannon, NIH director recombinant DNA technology. He was ap­ from 1955 to 1968, to promote public NIHAA Newsletter EditorialAdyisory pointed to head FDA in April 1977. discussion of issues that affect the Committee As FDA commisioner, he dealt with mission of intramural and extramural Storm Whaley, Chair , the ban on saccharin, the overhauling NIH. The event is supported by the Artrice Bader of the drug provisions of the Federal NTH Federal Credit Union. Michael M. Gottesman Victoria A. Harden Carl Leventhal Mark your calendar Robert G. Martin Abner L. Notkins Saul Rosen THIS IS YOURJNVITATIONTO THE SHANNON LECTURE Richard G. Wyatt

The NIB Alumni Association NTHAA Newsletter Board of Contributing cordially invites you to attend the sixlh Editors James A. Shannon Lecture PamelaE. Anderson Linda Brown "A Second Postwar Revolution in Giorgio Bernardi Biomedicine" H. Franklin Bunn Henryk Eisenberg Dr. Donald Kennedy Lars A. Hanson Wednesday, Nov. 20, 2002 at 3 p.m. George Klein Richard M. Krause Masur Auditorium, Bldg. 10 Richard McManus Carlos Monge Roger Monier Michael Sela

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NIHAA Officers Cyrus R, Creveling, President Research Festival '02 Slated for Oct. 15-18 Murray Goldstein, Vice.President Carolyn McHale, Vice President By Paula Cohen J. Paul Van Nevel, SeG-retary/1reasurer Preparations are well under way for these representatives. For a listing of Past Presidents the 16'hann ual NIH Research Festival exhibitors and more information, visit William I Gay, 1999- 2002 to be held on the Bethesda campus tl1e NIH Job Fair web site at William S. Jordan, Jr., 1997-1999 on Oct. 15-18. The festival organizing www.training.nih.gov/jobfair. CalvinB. Baldwin,Jr., 1995-1997 committee, co-chaired this year by Dr. Two days of scientific symposia be­ Thomas J . Kennedy, Jr., 1993-1995 Barry Hoffer, scientific director, gin with plenary session 1 on Wednes­ .Joe R. Held, 1991-1993 Gordon D. Wallace, 1990-1991 NIDA, and Dr. Thomas Kindt, direc­ day morning, Oct 16 from 8:30 - 10:30 tor, Division oflntramural Research, a.m. on "Biode.fense: A New NIH Board ofDirectors NIAID, has planned a wide-ranging Mission," is chaired by Dr. Thomas Alexander Adler program showcasing the scientific di­ Kindt, NIAID. Plenary session 2, Artrice V. Bader versity of the intramural research pro­ "Bench-to-Bedside: NIH Success Sto­ W. Emmet/. Barkley gram. ries," chaired by Dr. Barry J. Hoffer, Edwin Becker This year 's festival will follow a for­ NIDA, will be Thursday, Oct. 17 from William Branche, Jr. Samuel Broder mat similar to last year's, with two ple­ 8:30 - 10:30 a.m. Both plenary sessions Christine Carrico nary sessions, 12 mini-symposia, and will be held in Natcher Center-Audito­ Andrew Chiarodo four poster sessions; a job fair for rium. Rita Colwell postdoctoral fellows; a biomedical re­ The morning plenary sessions will be Julius Currie search equipment show; special exhib­ followed by concurre~t mini-symposia Murray Eden Joan Fredericks its on intramural resources; and several with topics solicited from the 1C scien­ Carl Fretts lunchtime food fairs as well as other re­ tific directors and members of the vaii­ Samuel S. Herman freshments served throughout the day ous special .interest groups. Four Margaret Heydrick (for details, see box on p. 4). poster sessions are also scheduled, fea­ Jane SundelofJones The NTH Job Fair for postdoctu.ral turing poster presentations by NIH .in­ l!win Kopin John Landon fellows, sponsored by the Foundation tramural scientists. L. Earl Laurence for the NIH and spearheaded by the The Technical Sales Association Carl Leventhal NIH Office ofEducation's acting direc­ will again sponsor the popular re­ Terry L. Lierman tor Brenda Hanning and fair coordina­ search festival exhibit show on Thurs­ Sally Nichols tor Shirley Forehand, will kick off re­ day and Friday, Oct. 17 and 18. Over .lames O'Donnell Vincent Oliverio search festival events on Tuesday, 400 exhibit booths will display state­ Karl Piez Oct.15. A keynote address on "From of-the-art equipment, supplies, and Richard Sherberl NIH Bench to the Biotech Bedside," services by leading regional and na­ Lawrence £. Shulman by Dr. Michael Zasloff, dean, research tional biomedical research suppliers in Joan Topalian and translational science, Georgetown parking lot l OD adjacent to the Clini­ Michael Walker University Medical Center, will begin cal Center. NIHAA Staff job fair activities at 10 a.m., in Natcher NIHAA members are encouraged to Harrie/ R. Greenwald Conference Center. The job fair will attend. Stop by and visit the NIHAA Mary Calley Hartman follow from ·11 a.m to 3 p.m. in the booth, in the front lobby of the Natcher Natcher Conference Center, and will Center, which is part ofthe special ex­

THE NIH A LUMNI Assoc1NnON THANKS host a number ofrepresentatives from hibits on intramural resources. WYETu, MERCK & Co., INc. AND THE industry, government, the acadernic Program booklets will be available FOUNllATlON FOR ADVANCED EDUCATION IN community, and nonprofit organiza­ this year. Final schedule detail.s are THE SCIENCES,lNc., FOR THEIR HELP IN UNDERWRITING TiffiPUBUSHJNG OFTFffiNI HAA tions. NIH postdoctoral fellows who available on the Research Festival UPDATE. W E ALSO T RANK TRE NIH FEDERAL are.completing their research training web site at http://festival02.nih.gov. CREDIT UNION FOR THEIR SUPPORT. W E and seeking permanent employment For information you may also call EXTEND APPRECIATION TO NlHAAMEMllERS \VUO MAKE DONATIONS BEYOND TH.EJR DlJF,S. will have the oppornmity to meet with 301-496-177 6.

3 N I H A A UPDATE

2002 NIH Research Festival Schedule, Oct. 15·18

(All Research Festival activities except for the Technical Sales show will take place in Natcher Conference Center)

Tuesday, October 15 Thursday, October 17

10:00 a.m. - 11:00 a.m. NIHJob Fair Keynote,c\.ddress 8:00 a.m. - 8:30 a.m. Continental Breakfast "From NIH Bench to the Biotecb 8:30 a.m. - 10:30 a.m. Plenary Session 2 Bedside" "Bench-to-Bedside: NIH Succes~ Stories" 11:00 a.m.- 3:00 p.m. NTHJob Fair for Postdoctoral Fellows 10:30 a.m. - 11:00 a.m. Coffee Break

12:00 p.m. - 1:00 p.m. NIH Job Fair Lunch 11:00 a.m. - 12:30 p.m. Mini-Symposia Session 3 Tent Behind Natcher Cafeteria Amyloicl formation Tech Transfer - Eureka! Chromatin Structure Wednesday, October16 1:2:30 p.m. - 2:00 p.m. Poster Session 3 Special Exhibits on 8:00 a.m. - 8:30 a.m. Continental Breakfast Intramural Resources Research Festival Lunch 8:30 a.m.-10:30 a.m. Plenary Session l: ''Biodefense: A Tent Behind Natcher Cafeteria New NIH Mission" 2:00 p.m. - 3:30 p.m. Mini-Symposia Session 4 10:30 a.m. - 11:00 a.m. Coffee Break ProteQmics Neural Immune Factors 11:00 a.m. -12:30 p.m. Mini-Symposia Session Chipping Away at Cancer Imaging involving brain & heart (ba'sk ) 3:30 p.m. - 5:00 p.m. Poster Session 4 Prions Special Exhibits on Intramural Stem Cells Resourc.es 12:30 p.m. - 2:00 p.m. Poster Session 1 Ref're§)lment_s Special Exhibits on Intramural Resources Research Festival Lunch Tent Behind Natcher Cafeteria Technical SalesAssociation (TSA) 2:00 p.m. - 3:30 p.m. Mh1i-Symposia Ses·sion 2 Research FestivalExhibitShowTenton ParkingLot lOD Imaging juvolving brain &· heart (adjacent to ClinicalCenter) {clfoical) Structural Biology Thursday, O<;t..17 9:30 a.m. - 3:30 p.m. Patterning Friday, Oct. 18 9:30 a.m. - 2:30 p.m. 3:30 p.m. - 5:00 p.m. Poster Session 2 Special Exhibits on Jntn,tmural Resources Final schedule is availabJe on the Research Festival web site Refreshments at http://festival02.nih.gov.

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Calendar of Upcoming Exhibits and Events

Elhlblts Masur Auditorium, Bldg. I 0. For October 2002-March 2003 more information and confirmation of National Libraryof'Medicine FAES Chamber Music Series the fulL schedule, call Hilda Madine, program director, at 301-594-5595. A new exhibit has opened in the The Chamber Music Series, sponsored NLM Rotunda; for more informa­ Oct. 9- Mider Lecture: by FAES, Sundays at4 p.m., has had to Dr. JeffTrent (NHGRI) tion call 301-594-7170. change its location. The concerts will Oct. 23 - Stctten Symposium: (2 Another exhibit on "Smallpox,"is now be held at the Landon School's p.m.) Drs. Douglas Laufenberger, on display outside the History of Mondz.ac Performing Arts Center. With Garrett Odell, Lucille Shapiro Medicine Division's Reading Room the exception of the Jan. 20 concert, all (NfGMS) until mid-November 2002. performances will be Sundays at 4 p.m. For more information call 301-496-7976 Nov. 6 - Astute Clinician: DeW ittStetten, Jr., Museum orvisitwww.faes.org. Dr. Henry Masur(NIH) Nov. 20 -Shannon Lectw·e: Oct. 6 - ChamberOrchestra ofPhiladel­ For more infom1ation about the Dr. Donald Kennedy (AAAS) Stetten Museum exhibits, call the NTH phia with lgnat Solzhenitsyn, conductor Historical Office at 301-496-66 10 or and pianist Dec. 18 - Khoury Lecture: Dr. Nadia Rosenthal (NCI) check out: www.nih.gov/od/museum. Oct. 20- Auryn Quartet with David Soyer, cellist Jan. 15, 2003 - Dyer Lecture: Other Activities of Interest Nov. 3 - Prazak Quartet Dr. SusanGottesman (NCI) :'llov. 17 - Peter Serkin, piano Medicine for the Public Jan. 12, 2003 - Viktoria Mullova, violin, Memorial Program fen-Dr. Donald A free lecture series on health and Charles Abramovic, piano Fredrickson onFriday, Oct. 18, in disease sponsored by the CC and Jan. 20 - Radu Lupu, piano (Monday, 8 Natcher Conference Center starting at presented by NIH physicians and p.m.) 9:30 a.m. with refreshments, then scientists, Tuesday evenings al 7 Feb. 2 - Richard Goode, piano program 10 a.rn. -11 :30 a.m., followed by p.m. in Masur Auditorium, Bldg. I 0. Feb. 23 - Wolfgang Holzmair, baritone, reception/buffet (see pg. 29). For more information call 301-496­ Russell Ryan, piano 2563. Mar. 2 - Winner Borciani Quartet Share tlle Health competition Sept. 17 - Bioterro1ism, Dr. Pierre :\1ar. 23 - Trio Fonrenay Saturday, Oct. 26, 8:30 a.m. - 3 p.m., an ''Exposition ofHealth from NIH to Noel M usic Lecture Series Sept. 24 -The Genetics of Speech its Neighbors," sponsored by the NIH and Communication Disorders, The FAES graduate school at NIH is of­ Office ofCommunity Liaison at the fering, starting Tuesday, Sept. 17, a per­ Dr. Dennis Drayna Natcher Conference Crenter, Bldg. 45. fonnance-leccure series presenting the en­ For more information call 301-650-8600. Oct. 1- Coping with Anxiety and tire cycle of 16 Beethoven string quartets. Virology Award Depression in Uncertain Times, Two classes will be held on Tuesday, but Dr. Dennis S. Charney the class is usually on Monday night from Thursday, Nov. 7, Fourth Dr. Nom1an Oct. 8 - Nutritional Therapies for 5:30 to 7:30 p.m. Formore information, call P. Salzman Memorial Award in Virol­ Age-re1ated Eye Disease,Dr. 301-946-2311 orsendane-mailto ogy Program al 8 a.m. in the Cloister, Emily Chew [email protected]. For a course catalog, Bldg. 60. Formore information call Oct. 15 - The Teen Brain, Dr. Jay visit www.faes.org. Carla Robinson at 301 -402-531 I . Giedd NIH Events NIHAA Events Oct. 29 - Endometriosis: Scrambled Eggs and Killer ThesixthJamesA. Shannon Lecture The NIHDirector's Wednesday After­ will be Wednesday, Nov. 20, 3 p.m. in Cramps, Dr. Pamela Stratton noon Lecture Series (WALS) is at 3 p.m. in Masur Auditorium. Dr. Donald Kennedy is the speaker. For more information about NIH events call 301-496-1766. For more information about NIHAA events caJI 301-530-0567. 5 N I H A A UPDATE

News From and About NIHAA Members and Foreign Chapters

Dr. Paul A. Bunn, Jr., who was at NCI as a section head in the Division of Dr. Julius Axelrod, winner of the 1970 Nobel Prize for Physiology or Medicine Cancer Treatment (1974-1984), was in­ while working at NIMH, was recently feted on the occasion of his 90lh birthday srn ll e

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also the recipient of the 1999 Rous­ Dr. Thomas Malone, who was atNIH Dr. Joe Mcintosh, who was a medical Whipple Award and the Ernst Jung (1962-1986) lastly as N1H deputy director, staff fellow in the NCI surgery branch Prize for Medicine, and the author of participated recently in an NIH program (l986-1989) and then was in pediatric more than 200 research articles. His re­ on "Successful Aging." In his talk he surgery, Children's Hospital ofBuffalo search is on hepatitis B and C virus in­ described himself as a "living witness for writes that "1 moved to Tampa and am fections and carcinogenesis studies. successful aging." Athletically inclined working at the H. Lee Moffitt Cancer from a young age, he has continued to Center and Research Institute." Dr. Vay Liang W. (Bill) Go, who was swim, jog and teach his be.loved judo with NIDDK as director of Lhc Division (NIH's Bldg. 31 fitness center is named Dr. Joseph Perpich, associate director of Digestive Diseases and Nub·ition after him). The most stimulating and for program pla1U1ing and evaluation at (1985-1988), is now at the Center for Hu­ valuable thing that he and his wife have NIH (1976-1981), currently beads a man Nutrition, University of California, done is to rear his grandchildren after Bethesda-based consulting company in Los Angeles. He was named recipient their mother was paralyzed in an automo­ program planning, development and of the 2002 Mayo Foundation Distin­ bile accident. He also took up flying assessment and information services in guished Alumni Award given by the lessons at age 50 and recently began the biomedical sciences, education and Mayo Medical and Graduate Schhols in learning to play the violin. "It's entirely medicine for academia, philanthropy, Rochester. He also received an honor­ satisfying to do this at an advanced age," industry and government. He served as ary membership from the Japan Pan­ he said. "I also think young. I don' t for a vice president for grants and special creas Society at its annual meeting in moment feel oract like I'm in my upper programs at the HHM1 (1987-2000), and Tokyo on July 4-5. seventies." was vice president for planning and business development at two Washing­ Dr. Leonard Herzenberg, who was at Marjorie Melton, who was at NMI and ton, D.C. metropolitan area biotechnol­ NIAID(1957- 1959), is now professor N1AID (1942-1972), has written the fol­ ogy companies ( 1981-1987). emeritus in the genetics department at lowing note: "In the summer 2001 Stanford University School of Medi­ newsletter of the NIH Alumni Associa­ Dr. RichardS. Rivlin, who was a clinical cine. He recently received the 2002 tion there was an article about the his­ associate in the Endocrinology Branch, Edwin F. Ullman Award at the American tory of Building 3, now being prepared NCI (1961-1963), is now senior vice presi­ Association for Clinical Chemistry an­ for 'decommissioning.' While the ar­ dent for medkal affairs aml Naylor-Dnna nual Oakridge conference in La Jolla. ticle was mainly about the biochemists chair in nutrition at the American Health The award is sponsored by Dade of the National Heart Institute, I was Foundation, New York City and Valhalla, Behring lnc. He was recognized for the inlerested that I found no mention of NY. He received tbe American College of development of monoclonal antibodies other groups that also occupied that Nutrition 2001 Award at the annual meet­ and the fluorescence-activated cell building. In May of 1943, the labora­ ing of the American College ofNutrition sorter as tools for biomedical studies. tory where I worked moved into Build­ on Oct. 5, 2001, in Orlando. He was se­ ing 3, the last laboratory to move to lected for his contributions to the field of Dr. Robert Lefkowitz, who was at the Bethesda campus from the building nutrition over an extensive career encom­ NlAMD(1968-1970), is now the James located at 26lh and E streets, NW, passing enom1ous research output as B. Duke professor of medicine and bio­ Washington, D.C. This laboratory was well as clinical experience and teaching chemistry, Duke University Medical testing drugs to find a substitute for ability. Center. He is also an investigator, quinine to treat malaria in the U.S. Howard Hughes Medical Institute. On forces fighting in the South Pacific. Dr. Norman Salzman, an NlHAAmem­ June 19 he delivered in Masur Audito­ The laboratory was headed by Dr. G. ber, a pioneer in the field of virology, rium a lecture on "Bcta-Arrcstins: Traf­ Robert Coatney and PHS officer Dr. and a noted teacher and mentor died in fic Cops of Cell Signaling." He also Clark C.ooper. Dr. Nathan Eddy also December 1997. His family established participated that day in a symposium had an office in that building. I was a fund at the Foundation for the NIH to honoring Dr. Henry Metzger, scientific out of the country from 1948-1950, and support a Norman P. Salzman Memorial director, NIAMS, who will be retiring when I returned the malaria laboratory Award in Virology. On Thursday, Nov. 7 this fall. was now located in Building 5." at 8 a.m. at the Cloister, a post-doctoral student will receive the fourth Norman

7 N I H A A UPDATE

P. Salzman Memorial AwardinVirology. man of medicine at both Michael Reese As NIH director be oversaw a budget For more infonuation about the fund, con­ Medical Center (University of Chicago) increase of from under $11 billion to tactthe FNJH, LCloister Court, Bethesda, and the Albert Einstein College ofMedi­ nearly $18 billion, instituted changes in MD 20814orcall 301-402-531J. cine. He has recently been honored by the intrnmural and extramural research bis colleagues in both pharmaceutical programs and recruited leaders for the Randy Schools, president of the R&W medicine (fastLifet:imeAcbievement institutes. On June 13, he received the at NIH and involved in fund-raising for Award from the American Academy of medal in a White House ceremony. NIH charities and other humanitarian Phannaceutical Physicians) and academia causes, was surprised on June 4 when (2002 Special AchievemeutAward from Dr. J. Craig Venter, ch ie.f of the recep­ Montgomery County Executive Doug the Association of Professors of Medi­ tor biochemistry and molecular biology Duncan presented to him an award for cine). He writes: "Ilook back on my Nlli section, NINOS (1987-1992), is now his deep community involvement in days with great fondness. I am a firm be­ chairman, the Institute for Genomic Re­ making Montgomery County a better 1iever and advocate for the synergies of search, Rockyille, Md. He was recently place to live. He was recognized for his gpvemment, academia and industry in elected to membership in the National community work above and beyond the bringing the full fruits of basic research Academy of Sciences. call of duty, as well as for his commit­ to the benefit of mankind." ment to improving the quality oflife for Dr. Gary Williams, who was at NCI the poor and underprivileged in Mont­ Dr. Ana Szarfman, who was a visiting (1969-1971), is now professor of pathol­ gomery County. associate in the connective tissue sec­ ogy and director of environmental pa­ tion, Laboratory ofDevelopmental Biol­ thology and toxjcology at New York Dr. Michael Sela, who was atNIDDK, ogy and Anomalies, NIDR (1980-1982), Medical Col­ (1956-1974), reports from Israel that "I is now medical officer, Center for Drug lege. Here­ am writing to keep you informed about Evaluation and Research, Food and ceived the the last Christian Anfinsen Memorial Drug Administration. In February 2002, Ambassador Lecture. It was given on Mar. 7, 2002, she was awarded the 2001 FDA Scien­ in Toxicology by Dr. Peter Schultz, a professor of pro­ tific Achievement Award for Outstand­ Award from tein chemistry Scripps in San Diego. at ing lntercenter Scientific Collaboration. theMid­ It was an extremely successful lecture, The citation is "For outstanding col­ Atlantic very well attended ...both myself and laboration for development and imple­ chapter of the Sara Fuchs are very much involved in mentation of a scientific and sophisti­ Society of the programming." cated signal surveillance system to Toxicology in identify potential safety concerns for 2001 and the Enhancement ofAnimal Dr. Louis M. Sherwood (National Heart medical products." Welfare Award from the Society ofToxi­ Institute J963-1966) retired from his sec­ cology in2002. He will convene the 1Q'h ond career at Dr. Harold Varmus, fom1er NIH diJector annual course 011 the safety assessment Merck&Co. (1993-1999) anda Nobel laureate for of medi.cines in Hyeres, France, Sept. 8­ cancer research, is currently president on Mar. 31, 13,2002. For infom1ation contact Bar­ and chief executive officer ofMemorial­ 2002; he bara Krokus@ nymc.edu. served as se­ Sloan Kettering Cancer Center in New nior vice presi­ York City. He bas been named a 2001 Dr. Jerome Yates, who was at NCI dent for U.S. National Medal of Science winner for where he helped create the Community medical & sci­ his career accomplishments. In 1989, he Clinical Oncology Program and advo­ entific affairs and Dr. J. Michael Bishop, chancellor of cated NCI-funded research on aspects and chief medi­ the UCSF, were award the Nobel Prize in of supportive care and cancer in the eld­ cal officer for Medicine or Physiology, for their dis­ erly (mid- l 980s), has been named na­ the past 10 years. He was previously ex­ covery that normal human and animal tional vice president for research at the ecutive vice pre,sident for worldwide de­ cells contain genes capable of becom­ American Cancer Society. He wi Usu­ velopment in the Merck Research Labo­ ing cancer genes, which led to the pervise worldwide scientific investiga­ ratories (1989-1992). He served as chair­ search for the genetic origins of cancer. tions and advances in 011cology, coordi­

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nate research initiatives with other ACS strategic programs and be involved in fundraising activities. After leaving NIHAA Members Who Recently Retired from NIH NCI, he was senior vice president of Dr. Gilbert Wheeler Beebe, one ofthe world's leading authorities in radia­ population sciences and senior vice tion effects, recently retiredat age 89 after a 60-year research career. He presidentfor clinical affairs at Roswell plans to remain at NCI as scienti.st emeritus. After a long career studying ra­ Park Cancer Institute in Buffalo. diation effects, he joined NCI in I 977, as a health statistician in the epidemiol­ ogy program. After the Chernobyl nuclear accident in Ukraine, he along Dr. Robert Young, president ofthe Fox with investigators in Ukraine and Belarus and at Columbia, studied children Chase Cancer Center, Philadelphia and exposed to radioiodines, and 88,000 cleanup workers exposed to whole body Dr. Robert F. Ozols, senior vice presi­ gamma radiation. On.Tune 18, the board ofRadiation Effects Research of the dent ofmedical science at Fox Chase, National Research Council held the Beebe symposium in the new NRCl build­ 11 have been awarded the 25' Bristol­ ing in Washington in his honor ... Martha Fewell, administrative assistant to Myers Squibb Award for Distinguished four NCI directors since 1987, retired in June after29 years at NCI. She Achievement in Cancer Research, a started as an assistant in the Cancer Therapy Evaluation Program. In 1979, $50,000 cash prize. Their research, be­ she became an assistant to Dr. Eli Glatstein, who headed the Radiation Oncol­ gun at NCI when they were both work­ ogy Branch in the Clinical Oncology Program, DCT. She worked for 8 years ing inthe NCI Medicine Branch (Young at the Clinical Center until moving over to the NCI director's office. She and joinedNClin 1970 as senior investiga­ her husband Joe Fewell, who also retired from NCI several years ago, plan to tor and attending physician and Ozols move to Florida to be near their daughter and otherfamily members ... Edwin came in 1976 as a clinical associate), Haugh, who joined the staff of the Journal ofthe National Cane.er Institute has contributed to the understanding in 1976 retiredin January. He served as managing editor of the Journal from of how ovarian cancer and tumor resis­ 1980 through 1987. Since retiring he has assisted in the publication of the tance develop. They demonstrated NJHAA Update . .. Janyce Hedetniemi,firstdirectoroftheOffice ofCommu­ that combination therapy for ova1ian nity Liaison, who bas had a 25-year career at NIH, retired in.Tune. She has cancer is more effective than single servedthree NIHinstitutes, NICHD, NHLBT and NIGMS. Before joining drugs and were among the first to rec­ NIH, shewas a member ofthe senior staffof the President's B iomedical Re­ ognize the importance ofplatinum com­ search Panel. As director of OCL, she worked with the community about a pounds in ovarian cancer. The chemo­ myriad of issues and problems concerning parking, construction, lighting, therapy regimen they developed has noise, environmental issues, tree preservation and NIH security to name just become standard therapy for advanced a few. Now retired, she looks forward to spending more time with her family ovarian cancer. and friends ... Dr. JeanneKetley, chief of the cardiovascular science initial review group at CSR, retired from NIH in a blaze ofglory. A fire truck with lights flashing and sirens wailing took her happily to her retirement lun­ What's Your News? cheon. Her NlH career encompassed research workat NIDR, NIAMDD (now NTDDK) and then NIA. She joinedDRG in 1979 where she headed various We want to hear from you. study sections. She became chief of her lastjob in 1995. Now retired, she Please send your news with went on a cruise, hopes to open~ her own business and just enjoy her retire­ photo if possible to Harriet ment . . . Donna F. Spiegler retired in.Tune from the Division of Safety in the Greenwald,NIHAA Update, 9101 Office o:f Research Services . .. R. Anne T homas, who was NIH associate Old Georgetown Rd., Bethesda, director for communications, has retired. She held a variety of communica­ MD 20814-1522oremail tions positions for more than 30 years at NIH. She is now vice president, [email protected]. public affajrs at Memorial Sloan-Kettering Cancer Center inNew York. She What's Your Email? will qversee a wide range of communications efforts including media rela­ tions, web site design and content, publications, community affairs and If you would like to send us special events. your email address, please send it to the above email address.

9 N I H A A U P D A T E

ALetter from NIHAA President Dr. Cyrus Creveling NIHAA Wants You I am honored to become the new president of the NIH Alumni Associa­ tion. It will be a real cha)lenge to follow in the footsteps ofthe successful The NIH Alumni Association term of Dr. William Gay. With the assistance of our board ofdirectors, the (NIHAA) has launched a volunteer following goals and activities will be acted upon: program. Currently our program is To increase our membership (attempts are in progress to work more effec­ targeting retired or soon to be re­ tively with the personnel offices at NIH to contact new retirees and to make tired NIII'ers in the local metropoli­ our presence known inTetirement seminars); to publish NlHAA Update tan area. We are still in the recrujt­ three issues a year; and to expand the NIHAA web site. The current web ing phase and want to have you as page ( www.fnih.org/nihaa.html) lists our officers, board members, commit­ a volunteer! tee chairs and members, our forthcoming activities and provides a "career Retirement can be thought of net" for NIHfellows. having lots of free ti me. Instead, We have also started a "Volunteer Committee" with an emphasis on volun­ retirees should think of themselves teering not only at NIH, but in the outside community such as the Science as people with a vast amount of ex­ Teachers Association and the Montgomery County School system (see box perience in a variety of areas! Re­ in next column). We will continue to cooperate with the N1H History Office tirementis the "fun" partoflife to identify, describe, and locate historical artifacts and materials (e.g., photo­ where retirees can choose activi­ graphs) that are ofhistorical relevance to NIH. ties they enjoy. Volunteering is a The association will continue to participate in the annual ResearchFestival rewarding activity for both you both at NIH andFortDetrick, the Share the Health Fair, and the Community Li­ and the people with wh~m yon in­ aison program ofNIH, and to cosponsor the Shannon Lecture. We will teract. Volunteering is giving back strengthen om awareness and concern for the community on issues such as to the community. the proposed N1H fence, the natural gas line and the biotenorism building on The NIHAA bas eompiled a direc­ campus. We will also be involved in future reunion plans. tory of volunteer opportunities of The officers and the board will continue to explore integrating our aims specific interest, including opportu­ and goals with the Foundation for Advanced Education in the Science and nities at the Children's Inn and in the Foundation for the NIH. A SJ)ecial thanks to FAES for t heir financial the Montgomery County Public support of NIHAA. School System. Other opportuni­ Our annual meeting was well attended with more than 70 members present. ties include: helping atthe Clinical The 2002 Public ServiceAward was presented to Dr. Donald Fredrickson. Cente(, participating in the NIHAA The first Award for Service to NIH was presented to Dr. Ruth Kirschstein. A or NIH speaker's bureau, language certificate was given to Dr. William Gay inappreciation for his outstanding interpreting for the CC, mercury service as president. education for the NlH Environmen­ One last note - we are all saddened by the untimely death ofDr. Fredrickson tal Branch (training provided), con­ on June 7. The NlHAA is helping with the memo1ial program tor him on Fri­ ducting v'isitor tours, and judging day, Oct. 18, at tbe Natcher Conference Center (seep. 29). science fairs and other events wjth the Office ofEducation. Shown together at the To find out how yoo can give annu al meeting on back to your community with re­ June 1 are Dr. Cy ru s warding volunteer work, call "Bob" Creveling (I), Maggie Heydrkkat301-663-6043 or incom in gp resident, Dr. visit http://www.fnih.org and click Donald S. Fredri ckson on NIB Alumni Association. You (c),th e 2002 NIH AA publicservice awardee, wil I find the volunteer information and Dr. William Gay, under Activities. Interested volun­ outgoing president. teers can complete the online form to participate.

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Amrnal Meeting (continued from p. 1) porting, more epidemiologists, new fa­ go toward more research in microbial Dr.William Raub, longtime NIH official cilities, inf01mation technology and genomics, proteomics and bioinformatics. and former deputy director, gave a public education regarding the nature of For the long te1m it is necessary to under­ gripping presen­ risks, as well as !raining and education stand the genetic basis of microbial viru­ tation on for all levels of public health specialists lence and development of drug resistance. "Enhancing in dealing with potential outbreaks. IL is At the conclusion of his presentation, Preparedness for recognized that the quality and rapidity Raub introduced Dr. D.A. Henderson Bioterrorism." of response at the local level can deter­ who was recalled from retirement to Raub, now mine the severity and duration of an head the Office of Public Health Pre­ deputy di rector outbreak. Coopera tive agreements have paredness. Henderson is known world­ oftheDHHS been executed with state health depart­ wide for hls leadership in the success­ Office of Public ments in the amount of more than $1 bil­ ful effort to eradicate smallpox. He told Or. WilliamRaub Health Prepared­ lion to enable them to plan for a consis­ the members and guests that there is a ness, was joined in the discussion by tent response. A parallel investment is lack of recognition on the part of the Dr. D. A. Henderson, former director of being made with the CDC to enable a United States of the extent of the pro­ the preparedness office. suitable national response. gram of the former Soviet Union in bio­ Events of the past fall had brought Raub noted that our nation's re­ logical warfare, and that there remains biotcrrorism to the forefront of public sponse to an attack of bioten-orism has worldwide concern over the plants that consciousness as a most serious danger, both local and national components. manufactured and stockpiled smallpox Raub told the audience. He likened the He stated that the national component virus and anthrax spores. havoc created by biological terror to the is fai rly strong and told of the National Henderson estimated that 80% of the aftermath of a nuclear attack but pointed Pharmaceutical Stockpile that consists U.S. population is folly" susceptible to out that a missile is not required to of millions of doses of antibiotics and smallpox. launch it-"only a few sick people." other agents in 12 locations around the He said that by December of 2002 he The budget for this health prepared­ country. Packs of these agents can be expects some 300 million doses of small­ ness effort has grown from $300 million moved anywhere in the country in 12 pox vaccine available. While it wi ll then last year to £3 billion this year and $4.6 hours and in most cases within 6 hours. be possible to make the vaccine avail­ billion has been requested for next However, state and local health depart­ able to the general population, he asked yea r. Raub regards this as an unparal­ ments need well-estabHshed protocols if this is a wise move, since smallpox leled opportunity to rebuild the public for rnass distribution of such vaccines vaccine is probably the most reacto­ health system that has been allowed to and antibiotics. genic vaccine there is. He stated that fa ll into disrepair over the past few de­ A second response component is the anthrax can be treated with antibiotics if cades. Laboratory Response Network for detected early, and that there is cur­ The health preparedness office has a rapid screening of lab samples at the rently available in the National Pharma­ four-pronged strategy for countering required level. A third level of re­ ceutical Stockpi le sufficient antibiotics bioterrorism: prevention, detection, re­ sponse is hospital preparedness to treat 20 million people for 60 days. A sponse, and research and development. through full sharing of information on vaccine is needed since the current one While much of the responsibility for their individual capabilities. The Na­ is painful and requires 6 doses. The prevention rests with the military, law tional Disaster Medical System of the Army is actively involved in vaccine de­ enforcement and intelligence agencies, federal government has teams of doc­ velopment in concert with NIAID with a the CDC has been given new authority tors, nurses and other health profes­ goal of having a vaccine within 18 to regulate the use, possession and sionals to be deployed as needed. months for those at highest risk. transfer of select pathogenic agents. In closing, Raub stated that, "TI1e limi­ The association 's 2002 Public Service The challenge is to all ow research to tations of the present dictate the future Award was presented to former NJ H di­ continue under this more stringent regu­ directioris (of research and develop­ rector Donald S. Fredrickson. Alumni lation. ment.) There is not enough smallpox members and the scientific community The detection initiative will require that vaccine. There is no good anthrax vac­ worldwide were shocked and saddened infectious disease surveillance be en­ cine. There are no truly effective antiviral to learn of his death only 6 days later, hanced, involving improved case-re­ drugs." At NIH, increased funding wi ll on June 7 (seep. 30 of Update).

11 N I H A A U P D A T E

Zerhouni (continued from p. I) than an individual cell, which holds White House, Zerhouni concluded, from his native Algeria whom he has "al I human DNA- the entire molecular "As an immigrant, lam very touched known since the sixth grade, fielded machinery... While we have discovered by being here today. Tt says about our mostly compliments from Kennedy's the component parts of the human ge­ great country what no other country committee, who cal led him a "rare find," nome, the real challenge for the 21"1 can say about itself." an encapsulation of the American century is to discover how all the parts Kennedy began the questioning, ask­ dream, and a man whose trademark hu­ work together. That is the biggest chal­ ing Zerhouni what he hoped to achieve mility should not, in the words of Sen. lenge for medicine." The quest will re­ as director. "I want to reestablish mo­ John Warner (R-Va.), prevent him from quire multidisciplinary teams and rale and momentum, and provide the vi­ "going at it with both fists fin Con­ cross-cutting initiatives, he said, as sion and energy to recruit a number of gress) to get everything you can get well as the "creative spark of the indi­ institute directors in order to make the forNlH." vidual that leads to TICW knowledge and agency even more effective than it has Committee members Sen. Paul Sarbanes progress." been," Zcrhouni said. He added that ofMaryland, along with Sen. Barbara Zerhouni- who has also been vice priority-setting would be a major chal­ Mikulski, also ofMaryland, offered in­ dean for research at Hopkins, as well as lenge. "Science is evolving at such a troductory biographical details about a member of the National Academy of pace that cross-cutting initiatives need Zerhouni (see box on next page). Es­ Science's Institute of Medicine since to be encouraged," he continued. He tablishing a friendly tone from the out­ 2000, and has served on NCT's board of said he would work to enhance interac­ set, Sarbanes even told the hearing scientific advisors since 1998-ac­ tions among scientists, identify bottle­ that his wife, a schoolteacher, had in­ knowledged that advances in genome necks to research progress and address structed Zerhouni's daughter Yasmin and stem cell science have given rise to th~m. He also said scientists need and gained "a very positive impression "deep moral issues" and that the de­ more resources, and proposed a Na­ ofthe family." bate over such issues "can be polariz­ tional Molecular Library, which could Zerhouni, who was most recently ex­ ing." He said he had made a series of quickJy provide researchers with bio­ ecutive vice dean of the Hopkins medi­ personal visits with senators to discuss logical molecules of interest. "That's cal school, chair of its department of ra­ his views on these and other issues, my own notion," he cautioned. "l diology and radiological science, and and concluded, "Disease knows no haven't yet sought the advice of my professor of radiology and biomedical politics- NIH must serve all ofus ... it peers." He also mused about a Na­ engineering, said his experience in Bal­ must not be factional, but must remain tional Institute of Emerging Biotech­ timore has taught him that he could not factual." NIH's role is to present data to in­ nologies, to take advantage of a broad succeed without getting input from form debate on mor"dl issues, he said. range of breakthroughs in such areas many scientific disciplines, from the One of his greatest recent successes at as nanotechnology. most basic to the most clinical. With Hopkins was securing funds to establish On other issues, Zerhouni said he respect to the former, he declared, 'I am an InstituteofCell Engineering, which is ex­ would live within established guide­ convinced that fu rther fundamental dis­ pected LO take advantage ofstem cell re­ lines on stem cells and conduct such covery will help us face future chal­ search, an area where federal funding has research in an "open and transparent" lenges in healthcare." He added, "We lagged to date, he said. manner; emphasized that NIH should still have to make discoveries that will He completed his opening statement by play a major role in "ingraining a cul­ facilitate the way we deliver health acknowledging the outstanding service ture of safety" in trials involving hu­ care." Calling for a more rapid transla­ ofDr. Ruth Kirschstein, who has been mans; explained that clinical trials have tion of the fruits of basic research to acting NJ H director since Jan. I, 2000 their own "ecosystem" that must be patient care, he said, "Biomedical re­ (she was also hailed by virtually every managed and understood; and main­ search in the year 2002 is at a turning member ofthe committee, and was recog­ ta incd NIH must do more to understand point that may require new strategies." nized with an ovation) and the advice of the self-destructive behaviors that lie He then produced two items: a DNA Nlli's last director, Dr. Harold Varmus. behind much preventable disease. chip, representing a "revolution in "Both have been ve1y helpful to me dur­ Asked a very broad question by technology that is unprecedented in its ing this process," said Zcrhouni. Mikulski concerning managing every­ rate and scale," and a tiny needle Echoing a sentiment he expressed at thing from tire tmcks to Nobel Prize whose point was nonetheless larger his Mar. 26 nomination ceremony at the winners, along with recruiting and re­

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taining minority investigators, Zerhouni play an important calmly admitted that he dido 't have a role in enticing new catch-all answer in his pocket. Mikulski scientists to sray." laughed, "I'm sure the White House Kennedy ended warned you not to break new ground or the hearing by con­ break any knuckles today." gratulating President Zerhouni said the loss ofcapable mi­ Bush on nominating nori ties was the number-one problem in such a strong candi­ biomedkal training, observing that sci­ date. "l think our ence does a good job of attracting country is very for­ such trainees, but a poor job of keep­ tunate to have Dr. In a brief ceremony beginning the 84th ACD meeting (seep. 1), NIH deputy director Dr. Ruth Kirschstein passes the gavel to the group's ing them. "lt took me 5 years to break Zerhouni at the helm new chair, NIH director Dr. Elias Zerhouni (c). Introducing him is the in to being funded by NTH," he com­ NIH, of the and the head of his previous place of employment, ACD member Dr. William miserated. "I think role models could world is, too." Brody, president of Johns Hopkins University. New Director No Stranger to NIH

President Bush's choice to lead NIH world's first CT across basic science and clinical disci­ is not a stranger either to the agency or scan images of plines, a departure from traditional specialty government. From 1985 to 1988, he was a the brain soon ·silos' characteristic ofacademic medicine. consultant to the White House, and is cur­ after they were He is known as an innovator with a knack rently a principal investigator on threeNIH made by for identifying major trei1oswitbin complex grants, and coiavestigator on_ two others. England's Dr. situations, defining a vision and building He also holds five patents, one singularly Godfrey consensus for action." and four jointly. His 35-page curriculum vi­ Hounsfield, The Hopkins biography concludes, tae lists 157 publications as author or coau­ prompting his "Married to Nadia Azza, a pediatrician d1or, and l l book chapters. nephew's pur­ and medical school classmate whom he suit ofradiol­ met whm both qualified for the Alge­ According to a biographical sketch Dr. Elias A. Ze rhouni prepared by Hopkins, Dr. Elias Adam ogy, a field that rian national swimming team during Zerhouni, 51, was born in Nedroma,AJ­ combined his interests in physics and high school, the couple has three chil­ geria, a small mountain town on French mathematics with medicine. (Apoi­ dren. Will, 25, is a second-year student Algeria's western border. He was one gnant bonor for Dr. Zerhouni earlier at Harvard Law School. Yasmin, 22, just of eight children and his dad taught this year was his appointment as :finished her undergraduate work at Co­ math and physics. He came to the U.S. Hounsfield lecturer at the European lumbia University and will pursue a atage 24, having earned ltls medica1 de­ Congress ofRadiology.)" master's degree in education at Colum­ gree at the University of Algiers Zerhouni is credited with having "led bia. Adam, 16, is a junior at the Severn School ofMedicinein 1975. He com­ efforts at Hopkins to restructure the School in Severn a Park, Md., where the pleted his residency in diagnostic radi­ school ofmedicine's Clinical Practice farnil y lives. Now fluent in English, ology at Hopkins in 1978 as cruefresi­ Association; developed a comprehen­ French and Arabic, and conversant in dent. Except for a 4-year stint in the sive strategic plan for research; helped German as well, Zerhouni plays lute department of radiology at Eastern Vir­ reorganize the school's academic lead­ and piano ('neither very well!' be in­ ginia Medical School, he has spent his ership and worked with elected officials sists) and shares an enthusiasm for op­ entire career at Johns Hopkins. to plan a major biotechnology research era and tennis with his wife [who works Zerhouni 's choice of radiology, says park and urban revitalization project at tl1e international adoption clinic at the Hopkins bio, reflects tlie influence near the Hopkins medical campus... Johns Hopkins]." He adds, "Free and ofhis maternal uncle, a. well-known ra­ Z.erhouni believes that bringing the scuba diving with the kids is something diologist who trained in France and fruits of biomedical research to the bed­ we love doing, too." Sweden. "He showed Dr. Zerhouni the side requires integration of discoveries

13 N I H A A UPDATE

ACD (continued from p. 1) sense of humor, he plays the lute and tors who nurtured me and helped me "I sort of feel Jjke the father of the the piano, loves to scuba dive and Us­ become the physician, teacher, re­ bride," Brody quipped, before launch­ teo to opera. It's a great loss for searcher and executive I am today ... r ing into an abbreviated biography of Hopkins, but I think it's a wonde1ful wouldn'thave left Johns Hopkins for the new director thal was sprinkled Jjb­ gain for NIH. Congratulations, Elias." any other job." Immediately revealin.g the quick sense erally with personal notes about the Accountability, Communication Top List friendship and high level of profes­ of humor alluded to in the introduction, sional respect that have developed Zerhouni began his remarks, smiling Zerhouni then briefly touched on over more than 20 years between him­ broadly: "First let me say thank you to three overarching priorities be said he self and Zerhouni. "When President Bill Brody for all his nice comments. gleaned from his meetings in Congress, Bush announced his intention to nomi­ Bill, if you had said all those things to his experiences during the confirmation nate Elias as director of NIH, a col­ me before, I would have stayed." process and his 14 days on the job. league of mine from the West Coast Sobering, Zerhouni acknowledged, "The first and foremost message that called me and said, 'Gee, they ap­ "There are few things that happen in I received from every senator, every pointed a radiologist. That's kind of one's life that are important and critical congressman, everyone in the adminis­ unusual.' And l said, ' Well, describing to what happens to you. [For me] , one tration and outc;ide the NIH commu­ Dr. Zerhouni as a radiologist is like de­ of them was meeting Bill Brody. If I nity," he said, "is the doubling of the scribing Bill Gates as a computer pro­ have to count the three or four things budget and questions about whether or grammer.' Elias is one of the most that have been determining, I would not it is well used. 'How do we know it broad-gauged people that l lmow in the say that crossing paths with Dr. Brody is well used?' 'What does the public field of medicine and biomedical sci­ was one of them." gain for it?' There is a huge cry out ence." The new NIII chief then contrasted there for accountability arid transpar­ his last position with his cun-ent. De­ ency. This I think is going to be a con­ Warm Welcome scribing the various hats he wore at stant theme over the next few years. JHU, Zerhouni joked about what he This is a concern that really comes Himself an expert in the field of radiol­ called "the Hopkins reengineering across every layer of the many bosses ogy, Brody continued, "Many of us in method (four jobs for the price of one.) that I'm talking about." biomedical science strive to have an im­ The difference here though is 1 have The second issue that Zerhouni portant discovery or invention, but one job and many bosses - Congress, said he "heard over and over again" Elias has bad a number of them. I think White House, the Administration. It's from everybody is "science policy in that regard, he's quite unusual. Early quite a daunting position. With that as being influenced more and more by in his career, Elias discovered tbat there a preamble, I'm very honored and ex­ earmarks. This is something we need was a way to differentiate benign from cited to be here. I saw the composition to grapple with" and perhaps curb in malignant nodules on computer tech­ of the committee and I am very im­ someway. nology which then sparked a tremen­ pressed and thankful for having your "The last but not least concern," he dous controversy because people adv ice and support." concluded, "is the level of expectation couldn' treproduce the work. So Elias ZerhOLmi said he'd had a lot of job of­ of the public such that there is now a then went into the detailed physics of fers over the years that he had "de­ cry for effective translation of the dis­ computer tomography and showed clined within 10 seconds," but that coveries into tangible benefits." why (depending on the type of scanner he'd once acknowledged in a meeting Elaborating, Zerhouni related a phe­ and how lhe method was conducted) that "probably the only one I would nomenon that was described to him to you could come up with en-oneous re­ consider is an NIH job, because I ad­ illustrate the point: "A hypothesis sLLlts. l think il was this work that made mire NIH." He had expressed similar says, 'You know, the cure can be here Elias a consultant to the Reagan White feelings in a May 17 farewell message in 5 years, if we only bad X amount of House during President Ronald to colleagues and friends at Hopkins, dollars.' One of the fundamental diffi­ Reagan's illness." writing, "You tookme in and exposed culties we have is that the research en­ Noting more ofZerhouni's break­ me to an extraordinary environment for terprise is often compared to the moon through inventions, Brody said, "I innovation and discovery. More than shot strategy. 'Why is it that President could go on and on. He has a great that, you provided me with great men- Kennedy can say we'll go to the moon

14 SU MME R 2 0 0 2

ill 10 years aod we did it, and you scien­ interviewing candidates, NlMH's com­ emy, who talked about the possibility of tists tel l us you can' t get a cure in 10 mittee has interviewed already, expanding the academy. years for one thing or another?"' NIAAA's is "moving apace" and By the meeting's midpoint, the cordial Zerhouni said the issue proves why NINDS's is being reinstalled for a new tone of Zerhouni 's ACD initiation had basic discourse is needed with the pub­ search. At NIBIB, Dr. Roderic been well established, primarily by the lic regarding "the realities of science.'' Pettigrew, currently ofEmory Univer­ warm greetings that began the day. He said people involved in biomedical sity, has been appointed and will start 'We' ve known each other for years, sol science need to spread the word to the in early fall; Dr. Marvin Cassman's de­ don't need to introduce myself to you," public: "When we talk about going to pa1ture from NIGMS since the last ACD said ACD member Dr. Donald Wilson, the moon, we're really talking about an meeting was acknowledged and acom­ vice president for medical affairs and dean incremental technological challenge. minee to fill that spot is under way. of the School of Medicine at the Univer­ We know where the moon is. We see it Kirschstein also noted that several va­ sity of Maryland, addressing Zerhouni every night. Fundamentally, we lcnew cancies on the ACD roster had been de­ and leading the first of many of the we could get there. We knew the laws liberately left open ill anticipation of group's personal tributes to Kirschstein. of physics. We knew the laws of grav­ Zerhouni 's arrival and subsequent input "For at least the last 30 years, I've been ity. We knew escape velocities. That on nominees. an employee of the NIH for several days a kind of project was a technological chal­ NIH deputy director for extramural re­ year, and over this time it's been my privi­ lenge. People need to convey the mes­ search Dr. Wendy Baldwin then gave a lege to work with our Ruth Kirschstein sage that in biomedical research we're short briefing on the stem cell registry and I just want to thank her for au she's not just dealing with a technological and announced that three more memo­ done over the years." challenge that has a well-defined end­ randa of understanding and six new Attempting to stave off the barrage of point and scientists are clear on just stem cell lilies meeliug Prelii

15 N I H A A UPDATE

Family Lodge Dedicated with Major Gift by Safra Foundation

By Dianne Needham Edmond was not my most important therapy patients and family members goal; it was my only goal," she said. need a facility where they can transi­ Personal stories can have a positive pub­ The lodge is planned as a temporary tion to home. They need a place where lic result, as is demonstrated in the case of residence for caregivers of patients they can gain confidence in home-care the family lodge planned for NIB. taking part in clinical trials. CC direc­ procedures in order to gain indepen­ A ceremony marking the naming of the tor Dr. John Gallin told the audfonce dence from the hospital." facility was held Apr. 17 at the Russell that patients come from every state in Offeri ng thanks to Lily Safra and the Senate Office Building in Washington, the union, traveling great distances be­ Safra Foundation, as well as to partners D.C. The Foundation for the NIH for­ cause of the hope that NIH provides in industry, for their generous gifts, Gallin mally accepted a $3 million donation - hope that "our research will save said the lodge would be a much-needed from the Edmond J. Safra Philanthropic their lives, or improve the lives of fam- refuge to welcome and comfort care­ Foundation and announced the givers. He predicts the facility will dedication of the Edmond J. Safra become an important model for Family Lodge at NTH. other clinical research centers. It was a personal story that NBC's morning news co­ caught the eye of Lily Safra, wife anchor Barbara Harrison moder­ of the late Edmond Safra, who ated the event. The program passed away in I 999. ln the FNIH also included FN1H board chair­ annual report she read the account man Dr. Charles Sanders, actor of a patient with metastatic kidney and patient advocate Michael J. cancer whose local doctor had Fox (who also suffers from told him nothing more could be Parkinson's disease), Ohio Con­ done, but that NIH was conduct­ gressman Ralph Regula, Massa­ ing a clinical study that might chusetts Sen. Ted Kennedy, and help. The patient would undergo Residents of the lodge (rendered above) will find amenities Dr. Patricia Grady, director, Na­ an experimental bone marrow that reflect the comforts of home as well as the support and companionship of others facing similar challenges. tional Institute of Nursing Re­ transplant at the Clinical Center, Groundbreaking will occur some time in the near future with search. which obliged him and his wife to completion projected for 2003. "This is what the Ametican remain nearby for several months. people are all about, helping When that story drew Mrs. Safra's at­ ily members, or the lives of others who people help others. As people commit­ tention, she stepped forward with a have their disease." He noted that pa­ ted to giving, Lily we thank you," said contribution to the foundation's Family tients frequently spend months in the Sanders. Regula noted, "Mrs. Safra, the Lodge Campaign. Her husband had Clinical Center and that it becomes Edmond J. Safra Family Lodge will stand suffered from Parkinson's disease, so their home away from home. Despite as a monument for years. Those who she knew ftrsthand about the chal­ special amenities such as recreation will never know you will realize that your lenges of being a daily caregiver. Un­ rooms, a gym and a school, he said gift says there are those who care." like many families dealing with illness, there was more that could be done. ''I want to thank Lily Safra for the however, she possessed the financial Gallin expressed concern about two work she does," added Fox. "Her gift resources to ease the burden. It was things in particular. 'The stress of here represents the high standard she her empathy for patients and their fami­ chronic and severe illness is enor­ brings to everything she does." lies in their most dire moments that in­ mous, especially when far away from Both Kennedy and Grady agreed spir~LI Mrs. Safra 's gifl. home, and too many families fracture. with Gatlin that the lodge might become At a mid-day ceremony in the Senate What is missing is a convenient place a model for others to follow. "Patients caucus room, she said the lodge reflects near the hospital to take a break and get better more quickly when they have "the spirit and values" of her late hus­ get a moment of sol itude, or take a a family member nearby and their tTeat­ band. "When my husband became ill, nap, or get a good night's sleep," he ment is more effective," said Kennedy, my world narrowed quickly. Helping said. "And following intensive adding that he hoped news of the Safra

16 SUMM E R 2 0 0 2

Family Lodge would soon "echo forth, causing it to be replicated throughout the country and world." NIH Buildings Eligible for Historic Register "Patients are often discharged from a Many of the original research buildiags located on the NIB campus are eligible hospital without knowing how to cope to be listed in the National Register of Historic Places as a result 6f the pioneer­ with their conditions," Grady observed. ing biomedical research that has been conducted on campus since 1938. The "Their caregivers are chaUenged, too. register is the nation's official list of buildings, structures, districts and sites that Care.gjvers need special knowledge to best represent United States history and architecture. The properties listed in deal with many challenging issues and the register are acknowledged by the federal government as worthy of preserva­ attend to their own health as well. An tion for their significance in American history and culture, and are SQ considered NIB program to address these issues during the planning of construction and renovation projects. The original research buildings, which fonn the NIH historic core district and officers' quarters historic district, were built in the 1930's and 1940's. They meet ATrib ute to EdmondJ. Safra register criteria for significance in American history, architecture, and culture, and During ltis lifetime, Edmond J. j:>Ossess integrity of location, design, setting, wortananship, and other distinctive Safra, considered by many as the cbarncteristics. These buildings include, listed by historic names: Bldg. l - Ad­ 20th century's greatest private ministration Building and Power Plant; Bldg. 2 - Industrial Hygiene Laboratory; banker, quietly conducted a major Bldg. 3 - Public Health Methods Bldg.; Bldg. 6 - National Cancer Institute~ Bldg. philanthropic mission. Rarely tak­ 4 -Institute for Experimental Biology; and Bldg. 5 - Microbiological Institute. ing personal credit, he supported Bldgs. I SB, C, D,E,F, Gare known as the officers' quarters, Bldg. 15Iis the NIH thousands of students, underwrote director's h.ouse and Bldg. 15H is the surgeon general's hou~e. medical research, built and restored The Memorial Laboratory Bldg. 7 is eligible for the register because it was schools and synagogues as well as one of the first bio-containment laboratories in the nation. All of the existing churches and mosques, endowed buildings that pre-date NIH on the Bethesda campus such as the Wilson Estate professorships and contributed to (Tree Tops), the Convent of the Sisters of the Visitation (the Cloisters) and the cou11tless humanitarian, religious, George Freeland Peter Estate (the Stone Hoµse) are also eligible for the na­ educational and cultural causes. He tional register. The Roeky Mountain Laboratory in Hamilton, Mont., js already founded the Edmond 1. Safra Phil­ listed on the National Register of Historic Places. anthropjc Foundation in 1999. The crown jewel of NIH's arcbiteetural legacy, according to the Division of After Safra's tragic death, lhe Engineering Services, is the National Library of Medicine, the world's lar.gest foundation and bis wife, Lily, who medical library. The library collects materials in all areas of biomedicine and was a charter member of the foun­ healthcare, as well as works on biomedical aspects of technology, the humani­ dation and serves on its cbunc.il, ties, and the physical, life and social sciences. supported many projects consistent Contrary fo what one might think, a building that is listed or eligible for listing with his vision and in his memory. on the National Register of Historic Places can be altered or even demolished. When a federal agency must alter an historic structure to meet program needs, it is required to consult with the state historic preservation officer, who gets an for Safra Family Lodge residents would opportunity to comment on the alteration. First the agency's federal preserva­ provide lasting benefits as they return tion officer must make a determination of effect. If the alteration, for example, is home and pick up their caregiving re­ to demolish the interior of a historic building, the officer will make a determina­ sponsibilities again. The program cou.ld tion of adverse effect on historic property. The federal and state preservation become a model for other research and officers will execute a binding memorandum of agreement that usually stipu­ care organizations to follow." lates how the agency will mitigate the loss of historic property. In many cases, Residents will find amenities that reflect photographic documentation is used, for this purpose. the comforts of home as well as the sup­ When NIH converted Bldg. 2 into an administrative office building, it was re­ po11 and companionship of others facing quired to prepare an historic American building survey document for the Na­ similar chal.lenges. Groundbreaking for tional Park Service to be included in the National Archives. the lodge will occur soon with comple­ For more information about the NIH historic preservation program, contact tion projected for 2003. Ricardo He1Ting, 301-402-2048.

17

SUMMER 2 0 0 2

scientists worked in the same room of Anfinsen 's laboratory. Former NIH di­ Documentary Film: Bldg. 3 in Historic Video rector and heart institute scientist Dr. On May 1, 2002, Dr. Buhm Soon Park premiered hjs documentary film on Donald Fredrickson recalled: "I [as a Bldg. 3 on the NTH campus. The video was made to show the l1istory of the clinical associate] got into a room of building's construction and give an idea of the scientfic research that has Thressa Stadtman's. I was there with been done there, focusing especially on the four laboratories that operated in four women and I thought all the scien­ Bldg. 3 in the spring of2000 before tists at the NfH were women." the bujlding's renovation. This clustering had not so much to Builtin 1938 along with Bldgs. l do with administrative obstacles as so­ and 2, Bldg. 3 was home first to the cial conventions that made male scien­ Division of Public Health Methods, tists reluctant about working with fe.­ with animal surgery rooms on the rnale partners or even their wives. The third floor and an animal breeding level of thefr reservation was greatly area in the attic. Furnace and me­ reduced in 1954 when Dr. DeWitt chanical equipment occupied the Stetten, Jr., was appointed associate di­ basement. rector of the National Institute of Ar­ After World War II, Bldg. 3 became thritis and Metabolic Diseases (precur­ the home for the intramural laborato­ sor ofNIDDK). He set a precedent for ries of the National Heart Instit11te, as other NIH couptes by working closely well as Dr. Arthur Kornberg's labora­ with his then wife, Dr. Marjorie Roloff, tory in the National Institute of Ar­ in the same section of the laboratory. thritis and Metabolic Diseases. In There were scientists such as Drs. 1962, Dr. Earl Stadtman became the Building 3, circa 1950 Bruce Ames and Marshall Nirenberg, chief of the Laboratory of Biochemis- who met, courted and married their life try in Bldg. 3, and in 1974, Dr. Edward partners on campus. Among other Korn became the chief of the Laboratory of Cell Biology. ln 2000 there were notable couples were the future leaders four labs in the building: Korn's Laboratory of Cell Biology; the Laboratory of NIH, Dr. Alan Rabson (deputy of Biochemistry led by Dr. Boon Chock, who had succeeded Stadtman; Dr. director of NCI) and Dr. Ruth Sue Goo Rhee's Laboratory of Cell Signaling; and Dr. James Ferretti 's section Kirschstein (two-time acting director of in the Laboratory of Biophysical Chemistry. These labs subsequently moved NlH and now deputy director of NIH). to Bldg. 50, as Bldg. 3 is now under renovation to be used as office spaces. Kirschstein 's remarkable career, which Five Nobel. laureates - Drs. Arthur Kornberg, Juli.us Axelrod, Christian included becoming the first woman to Anfinsen, Michael Brown, and Stanley Prusiner - worked in Bldg. 3, along head any institute at NIH (she became with three NIH directors - James Shannon, Donald Fredrickson, and James di.rector of the National Institut.e of Wyngaarden - and several dozens members of the National Academy of GeneralMedical Sciences in 1974), Sciences. started wben she was a resident physi­ The film is based on Park's interviews with scientists, technicians, and sec­ cian at the Clinical Center. Later, she retaries in Bldg. 3. The scientists discuss their research, explain the circum­ worked as a researcher in the Division stances that led to their arrivals at NIH, and point out some key research in­ of Bio1ogics Standards. This would struments. The film, which includes historical photographs from the Office not have been possible had the of NIH History, ably demonstrates the scientists' passion for their work and antinepotism rules been practiced at the friendly re·search atmosphere in Bldg. 3. It will provide an excellent his­ NIH as in academia. torical document for future scientists and historians. The video is available to those wbo are interested through Bulun Soon (The author is a DeWitt Stetten Jr. Park, [email protected] fellow of the NIH History Office and NHLBI.)

19 N I H A A UPDATE

New Facilities To Bolster Anti·Bioterror Effort called "Class A" agents are the most (jkeJy candidates to be employed By Rich McManus British troops used blankets and hand­ against civilians. These include small­ kerchiefs to spread smallpox to the Dela­ pox, anthrax, plague, botulinum toxin, In order to address the threat posed by ware Indians at Ft. Pitt, to World War £, tularemia, and some hemorrhagic fever biological agents used as a means to wben an animal disease known as glan­ viruses, many of which share common spread terror, NTH is building several new ders (Burkholderia mallei) was used, characteristics: they result in high mor­ research facilities to conduct studies on not too successfully, by German soldiers bidity and mortality, tbey offer the po­ such pathogens, including a major new to sicken the Allies' horses, mules and tential for person-to-person transmis­ structure-Bldg. B - to be completed sheep, to the modem era. Within the sion, a low infective dose is required to by 2005 on land that is now a carpool past 70 years, developed nations have start large damage, and the pathogen parking lot just east of Bldg. 31 's C wing. alternately embraced, and then rejected, can be aerosolized, or spread in a mist. The effort to build new laboratory use of such weapons in war. Further characteristics of the most likely space and upgrade existing research fa­ Until about 20 years ago, bioweaponry agents include an ability to contaminate cilities answers not just the need to pre­ was restricted to state vs. state warfare, food and water, a tendency not to be pare for the use of such organisms as which was a condition worrisome treatable, an ability to cause anxiety, anthrax, smallpox, plague, botulinum enough. But starting with the tainting and, finally, they can be weaponized. toxin and tularemia as instruments ofter­ of Tylenol with cyanide on store Key factors in a federal reaction to an ror or war; it aJso is part of a 20-year ef­ shelves in 1982, there has been a suc­ incident, said Kindt, include early detec­ fort mounted chiefly by the National In­ cession of incidents involving the use tion of the pathogen, a rapid public health stitute of Allergy and Infectious Dis­ of pathogens by individuals or small response, and the availability of vaccines eases to counter emerging and re­ groups to spread terror. Kindt touched or thernpies for those exposed. NIH, he emerging viruses and pathogens world­ briefly on some infamous cases: the said, is contributing to readiness via basic wide, including hanta virus, Ebola, and Rajneesh cult's use of salmonella to research including genomics of tbe organ­ multidrng-resistant tuberculosis. poison salad bars in 1984; the attack by isms and host responses to tbem, and the On the same day that NIAID made the Aum Shinrikyo group on the Tokyo development of diagnostics, vaccines and pub(jc its counter-bioterrori sm research subway system in 1995, when nerve antimicrobials. agenda - the fruit of a 2-day meeting gas killed 12 and sickened 5,000 people; Medicine's chief vulnerability to date at Pooks Hill last February by a blue and the discovery in 1995, based on in­ has been a dearth of state-of-the-art re­ ribbon advisory panel - the institute's formation provided by defectors, that search on pathogens due to a lack of fa­ scientific director Dr. Thomas Kindt both Iraq and Russia had large and cifaies equipped to study such bugs addressed a gathering of young poorly managed bioweapons programs. safely, Kindt said. He emphasized that the researchers in Lipsett Amphitheater Witb the world already on alert from "same levels of expertise and facilities" Mar. 14 to give an overview of the these incidents, enter the anthrax poi­ are needed to address such unintentional threat and how to combat it. "This topic sonings of fall 2001, a crime that made public health threats as MDR-TB and has dominated our thinking for the last bioterrorism a threat that Kindt said Ebola as are required to answer the delib­ several months," he said. was. finally. "too real to ignore." erate threats posed by terrorists. Unlike biowarfare, which is aimed Focusing primarily on his institute's He reviewed tbe escalating series of against troops lo achieve military ob­ response to bioterrorism, Kindt first safety rules governing pathogen re­ jectives, bioterrorism is targeted at ci­ pointed out that NlAID and NTH play search, ranging from BSL-1 (biosafety vilians, and need not necessarily result complementary roles with sister agen­ level 1), which is characteristic of most in immediate casualties, Kindt ex­ cies within HHS in the event of an at­ lab:; al NIH, tu BSL-4, lht: lt:vt:l 1~u iri11g plained. "One can instill a lot of terror tack; CDC, FDA and the Office of Pub­ the most extensive safety measures, in­ even without a lot of death and de­ lic Health Preparedness are also play­ cluding full-body suits, and sophjsti­ struction." He gave an overview of ers in the response. While he conceded cated filtering and decontamination of ev­ historical uses of biowcapons ranging that there are "an incredible number of erything going into and out of the lab. from the Middle Ages, when the things" a clever and welJ-trained scien­ At NlAID's Rocky Mountain Labora­ corpses of plague victims were cata­ tist could do to cook up a dangerous or tories, in Hamilton, Mont., a new BSL-3 pulted toward the enemy, to 1763, when novel pathogen, Kindt said that so- facility has just opened, Kindt said; it is

20 SUMMER 2 0 0 2

focusing on TB and Q fever (Coxiella burnetii). RML scientists are also study­ Resolution on Anti-Bioterrorism Facility at NIH ing Yersinia pestis (plague), and have re­ Approved unanimously May 2, 2002, by the NIH Alumni Association Board cently developed an animal model in of Directors which vaccine testing can begin, he re­ "Whereas, the September 11 terrorist attacks and their aftermath have in­ ported. Other bugs under investigation stilled in all peoples a great concern about potential bioterrorist attacks; and within NfAID include strep, pox virus, Whereas, the National Lnstitute of Allergy and Infectious Diseases of the Na­ vaccinia, anthrax, tick-borne encephalitis tional Institutes of Health is to be commended for its newly announced and West Nile virus, for which a vaccine 'Biodefense Agenda;' and is nearl y ready for testing. Whereas, the NIH Alumni Association strongly believes in the need to con­ "But we need some new facilities to duct biomedical research aimed at countering bioterro1ism; and make our program really fly," Kindt added. Whereas, the NIH Record reported on its front page April 2 that NIAID He said a new BSL 3/4 faci lity at RML has would erect a BSL-3 facil ity for anti-bioterrorism research on the carpool park­ been funded, and described a new ing lot of Building 31 C; and campus buildjng dcdkatcd to counter­ Whereas, Donald A. Henderson, director of the US DHHS Office of Public bioterrorism and emerging disease Health Preparedness, was reported to have said April 11 on an American Asso­ research - Bldg. B, which will include ciation for lhe Advancement of Science panel that 'even legitimate research BSL-3 labs. "Bldg. B will feature 175,000 holds the risk of a disease escaping from a controlled laboratory,' and gross square feet of space, including six Whereas, the NIH Alumni Association members believe that there is a risk, floors and a ground-floor vivarium. We're however remote, that a disease could escape from the planned anti-bioterrorism in the conceptual design phase now." facility, affecting NIH staff, neighbors, and commuters on Cedar Lane and Groundbreaking for the new lab building is Rockville Pike; and · expected in mid to late 2003, with comple­ Whereas, the NIH Alumni Association members believe that placement of an tion anticipated in 2005. anti-bioterrorism facility on the NIH campus would place major security pres­ Kindt also sajd that NJAID's Twin­ sures on NIH, resulting in a negative impact on the NIB campus environment, brook Ill Bldg. is going to get an ex­ and harming recruitment and retention of employees; and panded BSL-3 capacity, which should be Whereas, the NIH Alumni Association is on record as opposing any further available by December 2003, and an­ incursion into NIH parking because of the adverse affect on staff recruitment nounced that a BSL-4 facility is in the and retention; planning stages for the Frederick Cancer Therefore, be itRESOLVED, that while NIH Alumni Association members are in Research and Development Center. He favor of anti-bioterrorism research, any facility conducting such research should cautioned that ii isn't just the recent an­ not be built at NIH, where it might endanger members of the staff, NIH neighbors, thrax attacks that have prompted the new and commuters; could create a negative impact on the campus environment by push for faci lities. "Two years ago," adding additional, intensive security measures; and would consume critically Kindt said, "the Raub repo1t [written by needed parking spaces. The NIH Alumni Association further resolves that NIH fonner ND-l acting director Dr. WiJJjam should involve its scientific director and the scientific directors of all the institutes, Raub] and other reports concluded that as well as representatives of neighborhood groups, in determining a suitable loca­ we were neglecting a large number of in­ tion." fectious organis:ns, mainly due to a lack Response of Dr. Zerhounl to NIHAA Resolution of facilities for studying them. "There are major threats of bioterror­ Paul Van Nevel, NIHAA secretary/treasurer, sent a copy of the above resolu­ ism out there," he concluded. "We must tion to Dr. Ruth Kirschstein, NIH deputy director. He received the following re­ do the research and development sponse from Dr. Zerhouni. necessary to defend against any of the "I have reviewed your letter to Dr. Kirschstein transmitting the NIH Alumni agents that might be used." Association's concerns and resolution about the proposed Lab B Facility on (NIAJD's bioterrorism research lhe NIH Bethesda campus. For all the reasons mentjoned, I agree that this is a agenda can be found a1 serious issue that needs further review before a finaJ decision. www.niaid.nih.gov/dmidlpdfl Thus, I intend to review this in some depth and then will make a final decision. biotresearchagenda.pdf) Thank you for conveying the views of the Alumni Association."

21

SUMMER 2 0 0 2

Women's Health Time Capsule Buried on Campus CancerNet for Fellows:

The third annual celebration of Nati onal Women's Health Week, May 12-18, was Making Career Contacts punctuated on May 14 when the HHS Office of Wo men's Health (OWH) dedicated The Easy Way a Women's Health Time Capsule and buried it on tbe grnunds of the Lawton Chiles International House, known familiarly on campus as Stone House. The capsule, NlBAA members are invited to whicb contains more than 60 items that have had an impact on women's health in visit the CareerNet site at: http:// the past century, will be unearthed in 2100. felcom. nih . gov/Caree rs/Job net/ Guest speaker at a tea given in index.html. There, NIH fellows and conjunction with the dedication employees can view the current ca­ was Helen Thomas, a legend reer contact listings, and scientists among journalists, who served for in permanent positions can com­ 57 years as a correspondent and plete a form to volunteer as a career the first woman White House contact. bureau chief. She was the first Members of the NIH Fellows' woman officer of the White House Committee maintain the site by ad­ Correspondents Association and vertising, recruiting volunteers, and the first woman officer of the. periodic.ally updating the site. They National Press Club. For nearly 40 include information supplied from years, she covered presidential contacts both i nside and outside news briefings, from the presidencies of John F. Kennedy to Bill Clinton. She NIH, including NIH alumni. published her memoirs in 1999: Front Row atthe White House - My Life and Times. NIH alumni who wish to have their Event planne.rs included representatives from NIH's Office of Research on contact information added to this Women's Health, the Heal.th Resources and Services Administration Office of valuable resource may do so on the Women's Health, the Substance Abuse and Mental Health Services Administra­ web site. For more information please tion, and the Food and Drug Administration. They first unveiled the time capsule contact either Dr. Diane Lawrence on Dec. 3, 2001, at an OWH 10'h anniversary celebration and since then the capsule ([email protected]) or Dr. has toured all over the United States. Janaki Kuruppu Placed into the time capsule (see above) were items from a number of categories: ([email protected]). body image and health; diagnoses and treatment; legislation and policy; health education/communications; preventive health; quality of life; social and cultural factors (including a music CD and a Barbie doll).

New Children's Inn Addition Planned No longer will the Children's Inn at NIH have to say, "There is no room at tlie inn." That's according to Dr. Lori Wiener, presi­ dent of the inn, who sa.id a new wing will be built on the existing faci lity. "We often find ourselves overbooked, having to bump children back to hotels," sbe said. Wiener pointed out that dur­ ing the summers of 1998-2001, families were turned away on ~:- nearly 500 occasions due to space lin1itations. The new wing (shown in an architect's rendering) is slated to On April 24, a formal groundbreaking ceremony was held to open in 2003 and will provide space for 18 more families , mark the start of the wing's construction. bringing the inn's total capacity to 55 families . Before moving forward with the inn's expansion, a review was conducted on the inn's usage, institute protocols and future pediatric research plans. Based on this data, the inn's board of directors decided that in order to continue to support NIH pediatric research, a new wing was justified. Twelve years have gone by since the original groundbreaking for the Children's Inn.

23 N I H A A UPDATE

Mary Ann Guadagno bas moved to the NIH Notes January 2002 • July 2002 CSR to become the new scientific review administrator for the epidemiology and Appointments and professor of medicine, head of hematology, disease control 3 study section. She comes and director of hematology research at the from the NIA, where she coordinated grant Personnel Changes Lombardi Cancer Center at Georgetown review> for its behavior and social science of University ... Dr. Gary G. Christoph is the aging review committee ... Dr. James Dr. Ra ndolph Addison has joined the CSR new deputy director of the Center for Hanson has been named new director of as a scientific review administrator for the lnformation Technology. He will also serve NICHD's Mental Retardation and Develop­ SSS-U study section in the cell development as CIT's chief operating officer. Before mental Disabilities Branch. Before coming to and function integrated review group. Prior joining CIT, he served as first chief informa­ NJ CHD, he was acting chief of the Clinical to coming to CSR, Addison was a research tion officer and director, Office oflnforma­ and Genetic Epidemiology Research Branch, associate professor of biochemistry and tion Services, for the Center for Medicare and NCI ... Or. Ann Hardy bas joined the CSR molecular biology at Georgetown University Medicaid Services (formerly the Health Care as scientific review administrator of the social ... Dr. Abraham Bautista recently joined Financing Administration) ... Dr. Jeffrey sciences, nursing, epidemiology and methods the CSR as scientific review administrator for Elias recently joined Lhe CSR as the new 5 study section, which reviews grant the AIDS and related research 2 and 5 study scientific review administrator of the applications for the areas of biostatistics and sections. He was professor of physiology at behavioral and biobchavioral processes 5 research methods. She joins CSR from Louisiana State University Medical Center, scientific review group. He comes to CSR CDC's National Center for Health Statistics studying chemokine activity related to SIV from the University of Nevada in Reno ... in Hyattsville, Md .... Dr. Okihide and I !JV infections and alcohol use ... Or. Dr. Thomas Gallagher has been named Hikosaka recently joined the NEI Laboratory William Benzing recently joined the CSR as director of the NIH 's Office of Community of Sensorimoror Research. Formerly a scienti l'ic review administrator for the brain Liaison. He is experienced in both the public professor in the department of physiology at disorders and clinical neuroscience 2 study and private sectors and brings a diverse the J untendo University in Tokyo, be was a section. He comes to CSR from Gliatech, background in education and administration. visiting scientist (1979-1981) in the lnc. in Cleveland ... Or. Dale Birkle was Most recently, he served as principal deputy laboratory. His current studies focus on appointed scientific review aiministrator at assistant secretary for budget, technology, reinforcement learning ... Dr. Karen the NCCAM. She has a Ph.D. in pharmacol­ and finance at DHHS. He replaced Jan Hofman has been named director of the ogy. Her expertise focuses on the impact of Hedetniemi who recently retired ... Dr. FIC's Division of Advanced Studies and the physical and psychological environment Judith Greenberg has been named acting Policy Analysis. This division is responsible on brain structure and function ... John director of NlGMS. She is a developmental for analyzing social, economic and pub! ic Burklow has been named acting associate biologist who served as director of the health policies related to international director for communications and public NIGMS Division of Genetics and Develop­ biomccical research, with an emphasis on li aison at NIH. He had been deputy associate mental Biology for the past 14 years ... Dr. disparities in global health, and developing director and director of the Public Informa­ tion Division within the NIH Office of Communications and Public Liaison. He Pettigrew Is First NIBIB Director joined NTH in 1986 and was deputy director Dr. Roderic I. Pettigrew has been named first director of of NCI 's Office of Cancer Communica- the National institute of Biomedical Imaging and tions ... Dr. Marvin Cassman, NlGMS Bioengineering. He is currently professor of radiology, director, has left after nearly27 years at NIH. medicine (cardiology) and bioengineering and director of He is heading up a new University of the Emory Center for MR Research, Emory University California "Institute for Quantitative School of Medicine in Atlanta. He is expected to begin Biomedical Research" that will try to develop his appointment in late August or early September 2002. an approach to systems biology by integrat­ NIBIB was established in December 2000 and awarded ing the physical with the biological sciences its first grants in April 2002. lts mission is to improve ... Dr. George Chacko has become the health by supporting fundamental researcl1 in bioengineer­ scientific review administrator of the CSR 's ing and bioimaging science and transferring the results to new special review H study section, which medical applications. The instit11te also coordinates examines applications in computational ongoing efforts of NIH centers and institutes and biology. He trained as a veterinarian at the exchanges information with other federal agencies. Pettigrew is known for his College of Veterinary Medicine in Bangalore, pioneering work at Emory involving dynamic three-dimensional imaging of the heart India, but also received his Ph.D. in using magnetic resonance (MRD. He also was co-developer of the first computer biochemistry and immunology from Ohio software package specifically designed for cardiac ir:iaging using MR1. He has State University. He previously worked in received multiple grants from NIH for his research on cardiac imaging. More the NCI Laboratory oflmmune Cell Biology information on Pettigrew and NIBIB can be found at: http://www.nibib.nih.gov. . . . Dr. Bruce Cheson, head of the medicine section in the NCI Cancer Therapy Evalua­ tion Program since 1984, became on July 1

24 SUMMER 2 0 0 2

strategics and programs to address global the biobehavioral and behavioral processes Allergy, Immunology, and Transplantation hettllh concerns. She came to FTC in March 3 and 7 study sections at the CSR. Ni comes ... Dr. Richard Wyatt has joined the 1999 from Johns Hopkins where she served to CSR from Yale Un iversity School of Vaccine Research Center as chief of the as acting clinical director for the Center of Medicine where he led a research· team structural virology secti on in the Laboratory Medical Genetics ... Or.. J ohn F. " Jack" studying reading disabili ty using neuro­ of Virology. He comes to NIH from Jones, J r., recemly joined the CIT as chief imaging, eye-movement monitoring, and Boston, where he was an instructor and IT architect for NIH. He served as chief IT computational modeling ... Dr. Charles conducted research at Dana-Farber Cancer architect for Sandia National Laboratory and Peterson has been named director of the Institute and Harvard School of Medicine. most recently as senior advisor for Division of Blood Diseases and Resources, cybersecurity to the secretary. Department of NHLBI. He succeeds Dr. Barbara Alving, Awards and Honors Energy. Initially he wi ll focus on enterpri se wbo was appointed deputy director, NHLBI systems critical to the NJH mission. Hi s goal ... Dr. Luci Roberts has joined the CSR as Dr. Ahmed M. Elkashef, chief, Clinical is to optimize the useful ness of currenUT scientific review administrator for the Medicine Branch, Division of Treatment systems and services to support that mission behavioral and biobehavioral processes l Research and Development, NIDA, has . . . Dr. Rober t W. Karp has joined the study section. She comes from NICHD; for received the Physician Researcher of the NIDDK Division of Digestive Diseases and the past 4 years she was a fellow in its Year Award from the Commissioned Corps. Nutrition as director of the Genetics and Laboratory of Comparative Ethology, where He has fashioned both clinical pharmacology Genomics Program. Before coming to she studied the ncurocndocrinology of social sites and a clinical trials group in the Nl DOK, he directed the genetics program at bonding and parental behavior in nonhuman continental United States and Hawaii capable NlAAA (1991-2001). Mc will develop and pri mates ... Dr. Laura Shrestha has been of performing studies of potential pharmaco­ coordinate animal and hu man genetic studies named deputy associate director for the therapies for the treatment of cocaine and in digestive diseases and obesity .. . Dr. behavioral and social research program at the methamphetaminc dependence ... Dr. Robert J . Kuc-zmar ski recently joined the NIA ... Dr. Sherry Stuesse has joined the Anthony S. Fa uci, NlAID director. was NIDDK Division of D igestive Diseases and CSR as a scientific review administrator of named Mar. 27 as the winner of the Nutrition as director of the division's Obesity the brain disorders and : linical neuroscience $500,000 Albany Medical Center Prize in Prevention and Treatment Program. Prior to 5 study section and the brain disorders and Medicine and Biomedical Research, the joining NIDDK, he was a nutritionist and clin.ical neuroscience fellowship study richest award in medicine i11 the United health statistician for CDC's National Center section. She comes to CSR from the States, second only to the Nobel Prize for Health Statistics ... Or. .Jiayin "Jerry" Northwestern Ohio Universities College of worldwide. He was cited for his research on Li recently joined NIGMS as a program Medicine, where she was a professor in its AIDS and other diseases of the immune director in the Structural Genomics and neurobiology and phannacology department system, for his overall contributions to the Proteomics Technology Branch of the ... Freder ick C. Walker has been named advancement of science and for his distin­ Division of Cell Biology and Biophysics. He acting director of the N1H Office of Human guished public service. The prize also worked at Celcra Genomics and at the NCI Resources Management. He has been deputy recognizes Fauci 's role as a spokesperson Mouse Cancer Genetics Program in director of Human Resources since August after the events of Sept. 11, 2001 , and Frederick ... Dr. King Li has been appointed 2001. Since coming to NIH in 1972, he has following last fall's anthrax attacks. Fauci associate director of the Radiology and served in a wide range of OD management was honored during a reception and dinner at Imaging Sciences Department, and director of positions ... Dr. William Watson, a board­ the Franklin Plaza in Troy, N.Y. on Apr. 17 Diagnostic Radiology. Prior to coming to the certified laboratory animal veterinarian, has . .. Dr. Harold P. Freeman, director of the CC last summer, he was a tenured associate been selected as director of the NIH Center to Reduce Cancer Health Disparities, professor at Stanford University Medical Chimpanzee Sanctuary Program administered NCI, is one of four recipients of the UCSF Center's department of radiology ... Dr. by the National Center for Research Medal, the most prestigious honor bestowed Peter Lyster has joined the CSR as scientific Resources. He came to NCRR from by the University of California, San review administrator for the new study Tuskegee University where he directed the Francisco. He was described as "a national section that reviews applications for neuro­ Comparative Medicine Resource Center, advocate for poor and underserved patients informatics. He comes to CSR from the coordinated the Biomedicine Program, and who has focused critical attention and NASA Data Assimilation Office at Goddard taught at the College ofVeterinary Medicine. research on their needs and has argued that Space Flight Center in Greenbelt . .. Dr. Nursing, and Allied Health ... Regina H. poverty and diminished access to healthcare Ernest Marquez has been named NIMH White has joined the OD Office of Extramu­ are the principal underlying causes of racial a:.~01,;iate director for special populations; be ral Research as director of rile Office of disparities in death rates from cancer and wil l develop and coordinate research on the Policy for E xtramural Research Administra­ other diseases" ... Dr. Peter Greenwald, mental health needs of women and minority tion. She comes to NI H from the University director of the D ivision of Cancer Preven­ populations ... J ohn Meyer has been named of Vermont, where she spent 11 years as tion, NCI, received the American Cancer director of the Office of Review at the director of the Offi ce of Sponsored Programs Society Award for his research in chemo­ NCRR. He will oversee ihe office where, for ... Dr. Denise Wiesch has moved to the prevention, nutrition, early detection, bio­ the past 4 years, he has served most recently CSR to be scientific re,·iew administrator for marker development and validation, and as deputy director and before that as a its epidemiology and disease control 2 study preventive oncology training. The award scientific review administrator ... Dr. Wcij ia section. She comes from NlAID, where she was given at the American Society of Ni is the scientific review administrator for was a program officer in the Division of Clinical Oncology's 2002 annual meeting on

25 N I H A A UPDATE

Award for Senior U.S. Scientists. This award recognizes his lifetime career achieve­ Academies Induct Four NIH'ers ments and provides for extended stays to Four NIH scientists are am0ng an elite class of new inductees to the National Academy conduct research collaborations in Germany. of Sciences and the American Academy of Arts and Sciences, both of which announced their 2002 honorees at the end of April. Retirements Dr. Adriaan Bax, chief of the NMR biophysical spectroscopy section at the National fustitute of Diabetes and Digestive and Kidney Diseases, won membership to both Elaine P rice Beck, a manuscript editor with academies. Also namedNAS members were Dr. Harvey J. Alter, chief, infectious the Journal ofthe National Cancer lnstifute diseases section and associate director of research, department oftransfusion medicine, retired in January 2002. She came to NIAID Clinical Center; and Dr. J oseph F. Fraumeni, director, Division o'f Cancer Epidemiol­ in 1961 and in 1963 joined the staff of ogy and Genetics, National Cancer Institute. Cancer Chemotherapy Reports, which was In all, 72 new members and 15 foreign assocjates were nametl to NAS this year. merged with JNCT in 1988. She is now Election to membership in the academy is considered one of the highest honors that can enjoying time with her grandchildren and be accorded a U.S. scientist or engineer. NAS is a 11rivate organization of scientists and doing freelance editing .. . Jerry EIJiott, engineers dedicated to the furtherance of science and its use for1:he general welfare. It program and management analys.is officer at was established in 1863 by a congressional act of incorpotation. signed by Abraham the NIH Office ofMedical Applications of Lincoln, that calls on the academy to act as an official adviser to the foderalgovemmem, Research for the past 18 years, has retired upon request, in any matter of science or technology. from the federal government after 40 years of Also named an AAAS fellow from NIB, in il,ddition to Bax, is Dr. Sue H. Wiclmer, service. ln retirement, Elliott bas many cluef, DNA molecular biology section, Laboratory of Molecular Biology, NCI. activities planned ranging from an interest in Founded in 1780, theAme1icanAcademy of Arts and Sciences is an international Civil War history, hiking the entiJe Appala­ learned society composed of the world's leading scientists, scholars, artists, bu~iness chian Trail, playingracquelbaU and working people and public leaders. Its current membership stoands at 3,700 American fellows on his boat ... Robert MacKinnon, NIDDK and 600 foreign honorary members. retirement specialist, i.s retiring himself. Tuesdays and Wednesdays,'fiowever, l1e is still 011 campus as a consultant to help NIH May 18 in Orlando ... Dr. Van S. Hubbard, received an honorary Doctor ofSc ience human resources staff deal with retirement director of NIH's Division of Nutrition degree from his alma mater, California State and health benefits questions. In addition to Research Coordination and chief of NIDDK's University, Fresno, in recognition of "his hi~ work al NlH, he wilJ continue to play golf Nutritional Sciences Branch, is the first outstanding national leadership and and tennis, do volunteer work in a soup recipient of the North American Association dedication to the improvement of the quality kitchen and enjoy his retirement home in for the Study of Obesity's George Bray of life for all citizens" . . . Dr. Mark Ocean Pines, near Ocean City ... Dr. Sarni FotITTders Award. The award recognized his Mattson, cbief of NIA's Laboratory of Mayyasi, scientific review administrator of outstanding contributions in advancing the Neuroscience, recently received the CSR's AIDS study sect.ion, wb.ich reviews scientific and clinical aspects of understanding Santiago Grisolia Chair Prize in Valencia, AIDS immunology and pathogenesis grant and treating obesity ... Dr. Ruth Kirschstein, Spain. The award, named for a famous applications, has retired. He first came to NIH deputy director, recently received several Spanish scientist, was given to Mattson for NJ..H in 1983 and worked at NCI. His honors: the "K:irschstein Awards" is the new his contributions to the fields of aging and retirement plans include traveling with his name of the National Research Service neuroscience . .. Dr. David Moore, a wife to Hungary, playing more tennis, Awards, an NIH training grants program. clinical fellow in N INDS's Development visiting with his family and looking for Sen. Tom Harkin (D-IA) announced the and Metabolic Neurology Brancb, was opportunities lo help others ... Or. David nan1e, an expression of thanks to Kirschstein recently selected to receive the S. Weir Monsees, the scientific review administrator (who served as acting director from January Mitchell Award from the American for the epidemiology and disease control 2000 to May 2001) from members of Academy of Neurology. The award was study section 2, has retired after 24 years al Congress; she also received from the NIH given for his manuscript, "White Matter NIH. He now plans to devote more time to Alumni Association the group's first Award Lesions in Fabry Disease Occur in Prior his passion for archaeology and to take for Service to NlH, and she was also honored Selectively 1-1.ypometabolic and Hyperfused courses and join digs in the U.S. as well as by FASEB when they named a garden at their Brain Regions: A Pathopbysiological abroad ... Steven Parris, mailroom services headquarters in Rockville after her ... Dr. Model of Leukoarafosis," which describes chief, retired recently Mark A. Klebanoff, director of the Division his recent work on the etiology of after 39 years of of Epidemiology, Statistic: ~ and Prevention leukoaraiosis in Fabry disease. Since service to NlCHD. Research, NICI-ID, was inducted into the coming to .NINDS, Moore has also received For almost 40 years Johns Hopkins Society of Scholars on May lhe 2001. Oldendorf Award from the at NICHD, Parris 22. His research interests focus on the American Society of Neuroin1aging and the approached his work epidemiology of pregnancy complications, NIH Bench-to-Bedside Award in 2001 ... with enthusiasm, a particularly preterm birth and reduced fetal Dr. Paul Nettesheim, senior science strong work ethic growth ... Dr. Ernest D. Marquez, associate advisor to the director ofNIEHS, has been and a desire to director for spec.ial populations, NIMH, has named recipient of a Humboldt Research ensure that every-

26 SUMMER 2 0 0 2

thing was done as efficiently as possible. At where he was chief of newborn medicine at began as an editorial clerk with the PHS in the gathering for his retirement. more than Boston Children's Hospital and also chief of 1945 and rose to be managing editor of 100 current and former staff at N ICH D and the hospital's joint progr.im in neonatology at JNC/. She retired in 1975 ... NIH, including Cal Baldwin, the former Harvard Medical School ... Judith Dr . Peter Frommer, 70, former deputy NTCHD executive officer who hired him, Binstock, who worked for NCI in the director of the NHLBI, and a leader in wished him well ... Joan O ' Brien Division of Cancer Prevention for 21 years, biomedical engineering, died Mar. 7 after a Rodriguez, who came to NCI in 1958 as a died Mar. 15. She entered government hea1t attack and stroke. He had been battling clerk steno, retired in January 2002 as a service in 1979 with the PHS at the pancreatic cancer for 3 years. He was a manuscript editor with the Journal of the Parklawn Bldg. as a clerk typist and moved pioneer in biomedical engineering who also National Cancer Institute. She now spends to NCI in March 1981. She served with the helped create programs in myocardial time walking and reading poetry .. . Or. Chemoprevention Branch and most recently infarction and new approaches to research Martin Slater recently retired from the CSR with the breast and gynecologic cancer that brought together basic and clinical as scientific review administrator of the research group ... Pa ula Uene Bondy, 48, a studies. He was involved in the method­ microbial physiology an

27 N I H A A U P D A T E

cytometry-a way of examining the structure May 25 at hi s home in Potomac after a the executive committee of Shady Grove and function of individual cells. A memorial massive heart attack. Among cancer Adventist Hospital established a patient fund at the CAP Foundation has been set up researchers, he is known for the develop­ education oncology library in his honor ... in his name at the College of American ment of the "Mantel-Hacnszel Procedure," Barbara Coe Oxenham, 52, who was a Pathologists, 325 Waukega.'l Road. which was originally used to assess contracting officer in the procurement unit at Northfield, Ill. 60093 ... John Paul J ones, associations between an environmental NIH, died of renal failure and leukemia July 76, an NlH employee, died on Mar. 29 in exposure and cancer risk. His paper on this 2 at Shady Grove Adventist Hospital. She Delaware, OH, where he resided with his procedure was published in the Journal of retired this spring ... Dr. Richard J ames niece and sister while recovering from the National Cancer Institute in 1959 and Dick" Podolsky, 78, an internationally surgery. He had served as a mail clerk with has since influenced the design and analysis renowned muscle physiology researcher the Division of Support Services, ORS. He of subsequent epidemiological studies. He who made major contributions in the fields joined N1H in 1968 after h ~.v ing served in also devised methods to measure the safety of muscle physiology and muscle structure, the U.S. Navy. His combined military and of varying doses of drugs, evaluate died Oct. l 0, 2001, in Boston. At NIH, he federal service totaled 45 years. Of special diagnostic tests and assess exposure to served as chief of the Laboratory of Physical note was his participation in the blood donor radiation. After he retired from NCI he was Biology for more than 20 years. The lab program donating over I 00 pints and his a research professor at various academic was formerly part of the then National volunteer work for Alcoholics Anonymous institutions both here and abroad ... E lwyn Institute of Arthritis, Diabetes, Digestive and throughout his 34-year tenure with NIH ... L. Meencn who was at NIB (1957-1963) as Kidney Diseases but moved to the new Ann Landers, 83, the celebrated syndicated an administrative officer in PlantEngineering National Institute of Arthritis and advice columnist, died of multiple myeloma and Grants, died Jan. 20 ... Dr. Kenneth Musculoskelatal and Skin Diseases in 1986 June 22 in Chicago. Her real name was Mclmon, 67, who was at NIH ( 1961-1964) ... Dr. Harvey D. Preisler, 61, who was a Ester Pauline Friedman Lederer. She as a senior assistant surgeon and clinical staff associate in the NCI clinical trials actively supported the National Cancer Act associate at the Heart Institute where his medical branch in 1967, died of lymphoma of 1971 in her column. ln 1980, she was interest in medical research was initiated, May 19 in Rush-Presbyterian-St. Luke's appointed to a 6-year term on the National died Apr. R of a hP.11rt attack at his home in Medical Cent.er. He was director of the Rush Cancer Advisory Board and also served on Woodside, CA. After leaving NTH, he Cancer Institute in Chicago a·nd a leading the advisory committee to the director, Nil-I taught at the University of California S

28 SUMMER 2 0 0 2

the training of research psychologists. He since 1999 at NCI's Division of Cancer Charline Lovelle Jordan Weaver, 74, died also helped develop in the last decade Epidemiology and Genetics, died of cancer June 16 from non-Hodgkin's lymphoma at NlMH's A lDS research. His wife, Iris Byer Mar. 3 at her home in Silver Spring. She Casey House hospice in Rockville. She was Schneider, an NCI officia4 died in i 996 ... was a leading contributor to studies of a secretary in the grants management Dr. Susan M . Sieber, 59, a 30·year veteran radiation health effects in the former Soviet djyjsion of NIDA ... Dr. Richard Jed of NCI, died Jan. 22 in Rockville of breast Union. Her epidemiologic studies also Wyatt, 63. chief, Neuropsychiatry Branch. cancer. She joined NCI as a staff fellow in included work on occupational cancers, the NIMH, died June 7 after a long battle with 1971. Io 1980, she was appoimed acting effects of Agent Orange on Vietnam War cancer. He was a schizophrenia researcher chief of the Laboratory of Chemical veterans, ru1d the health of submariners ... who was one of the early pioneers in the Pharmacology. Over the next two decades, Rosemary Tobin, 78, a retired NIH intramural research program. He joined however, her interest in developmental employee, died of chronic obstructive NlMH as a clin.i.cal associate in 1967. While toxicology, biochemical epidemiology and pulmonary disease Mar. 22 at Forest Glen at NIMH, he created a model program in cancer in women and special populations Jed Rehabilitation Center. She came to Washing­ biological psychiatry research, led studies of to roles in a wide variety of NCI offices ton and worked for DHEW and NIH before schizophrenia, mood disorders, Alzheimer's including the Division of Etiology and the retiring from NIH ln the mid-1980s as an disease, brain grafts for Parkinson's disease, Division of Cancer Epidemiology and executive assistam ... Virginia A. Vogel, 83, neurochem.istry, sleep and neuroplasticity. Genetics. After serving as associate director a retired secretary who worked at NIH in the He also mentored and trained many of of special projects in the late 1990s, she was 1970s, died May 26 at Montgomery General today's leading neuroscientists ... Virginia appointed director of NCI's Office of Hospital. She had scleroderma. After she E. Johnson Zakotnik, 77, who worked at Communications in 2000. She retired from left NIH, she was a volunteer in the White NIMH as I'. nurse, died of stomach cancer Jan. that position late in 2001 . . . Guerry Riggles House communications office ... Virginia 6 at a nursing home in Om10nd Beach, FL. Smith, 93, wl10 worked for mnre than 10 M. "Ginger" Wantling, 63, a secretary at government agencies before retiring from Nll-1. [n the 1970s and 1980s, died Jan. 10 al Nrn. in 1968 as chief of the grants manage­ Kent and Queen Anne's Hospital in ment branch of the DRG, died Feb. 17 at his Chestertown, after a stroke. She joined the borne .in Arlingwn after a heart attack. He staff of Frances Humphrey Howard at Mis. Mary Calley Harttnan made a began working for the federal government in NLM. Sbe also worked for Dr. Vincent Gontribution to NIHAA in memory of 1927 as a copy puller for the superintendent DeVita when he was director of NCI ... Dr. Dr. Donald M. MacCanon, Hazel of documents at the Govemment Printing Vaman S. Waravdekar, a retired NCI Rea and Dr. Vaman S. Waravdekar. Office. He took accounting courses and took scientist, died Feb. 4, 2002. He joined NCI An ammymous contribution has up various accounting positions in the in 1948 as a PHS fellow to work with Dr. government. He joined NIH in 1963 ... Dr. Murray J. Shear in the Laboratory of beenmadeinmenrory of Dr. Robert Harold Stanley died Nov. 10, 2001 in Chemical Pharmacology. In 1957, he left to Berliner. Those wishing to make Florida where he had retired. At NIH, he join the All India Institute of Medical similar memorial contributions was assistant chief (senior dental surgeon), Sciences, New Delhi, [ndia, as a professor sl1ou1d contact NIHAA. Clinical Investigation Branch, NIDR in 1949 of biochemistry. He rejoined NCT in 1972 and 1953-1968. He was professor emeritus, to work in the Office of Program Planning University of Florida College of Dentistry. and Analysis until retiring in 1983 ... In the spring 1000 issue of Update he wrote about his experience with the first use of the drng tetracycl.ine ... Dr. Harry G. Steinman, Memorial Program for Dr. Donald S. Fredrickson who was at NCI from 1938-1977, died Apr. 11 , 2001 ... Dr. Katherine Duncan Tebow, A memorial programto honor Dr. Donald S. Fredrickson, formeI director of NIH 88, a retired medicalJesearch grants (Ju1y 1975 to June 1981) and internationally renowned authority on lipid metabo­ administrator at NlH (early l960s-1987), lism and its disorders, is sclietluled to begin Oct. 18, 2002, at 9;30 a.m. in the died of pulmonary disease Feb. 8 at Natcher Conference Center. There will be coffee/refreshments at9:30 followed Suburban Hospital. At NIH she worked for by the 10 a.m.-11 :30 a.rn. program, ending with the reception/buffet. what is now the Office of Human Research Protection. She then volunteered at the Please save the date and join the scientific community, friends and family in office- which is now a prut of HHS- four honoring him for his years of pr0fessional dedication, scientific excellence and days a week until 2000 . . . Andrew oursranding public service. Dr. Thomas Malone, fonner deputy director and Theodore, 96, a retired statistician who acting director qfNlll, will se.rve as master of ceremonies. The grogram will in­ worked at CDC as chief of the tuberculosis clude remarkis by spe;lkers who will describe different phases of his career and a research branch, died of sepsis July 22 at Suburban Hospital. After he retired from video illustrating his life. A ceception/buffet will be held foll0wing the program CDC and moved to the area, he continued to in the foyer area of the Natcher Conference Center where there will be posters work as a volunteer with Greek heart patients with highlights of his life and career. A commemorative booklet prepared for the at the Clinical Center ... Dr. Terry Lynn program will be provided to all attendees. Duel Thomas, 53, a senior staff scientist

29 N I H A A U P D A T E

Former NIH Director Fredrickson Mourned

Dr. Donald S. Fredrickson, 77, an authority on lipid metabo­ tional Heart Institute as a clinical associate. He was among lism and its disorders who was NIH director for 6 years (July 1, the first cadre of house staff for the then new Clinical Center. 1975, to June 30, 198 1), died on June 7 at his home in Fredrickson held numerous positions at NIH, several in the Bethesda. Only 6 days earlier, he had accepted the NIH heart insti tute simultaneously. From 1955 to 196 J he was a Alumni Association's 2002 Public Service Award in acer­ member of the Laboratory of Cellular Physiology and Metabo­ emony at Bethesda United Methodist Church. And he had lism. He then served as clinical director (1961-1966), while given a public lecture at NfH last December on a topic for continuing his research as head of the section of molecular which he became famous: legitimizing recombinant DNA re­ diseases, Laboratory of Metabolism (1962-1966). He was ap­ search at a time when public fears threatened to proscribe that pointed institute director in 1966, serving in that capacity un til avenue of investigation. 1968. He combined this responsibility with research as chief He said on Dec. 11 , 200 l, "We ' re ... in the midst of a revolu­ of the Molecular Diseases Branch (1966-1974), and as dirnctor tion and we have been for the past 30 years - and it's the of intramural research ( 1969-1974). most important one in the history of medicine and biology. I His earliest research interests centered on the metabolism of was in the first phase of it, and it was the most enjoyable pe­ sterols. Later he focused on the structure of the plasma lipo­ riod of my life, l think." His remarks capsulized a book he had proteins, their importance in the transport of fats, and the ge­ recentl y published, The Recombinant DNA Controver:;y: A netic factors regulating their metabolism and concentration in Memoir. The book's jacket reads, "In this fascinating memoir, blood. It was during this period that be discovered rwo new Donald Fredrickson tells the story of the controversy over re­ genetic disorders: Tangier disease (absence of high density combinant DNA and its revolutionary impact on modem sci­ lipoproteins) and cholestcryl ester storage disease, a lysoso­ ence.. .. Relying on vast archives of hearing records, corre­ mal enzyme deficiency. spondence, and extensive personal records and diaries, Dr. In 1965, he and his coworkers introduced a system for identi­ Fredrickson recalls the numerous personalities from microbiol­ fying and classifying blood-lipid abnormalities on the basis of ogy, molecular biology, and other scientific disciplines, as well plasma lipoprotein patterns. From this work came recognition as the leaders among Congress, the administration, and gov­ of new causes of hyperlipidemia. The system was adopted by ernment agencies, environmentalists, and many others, who laboratories around the world. had a role during this challenging period." Fredrickson and his colleagues also discovered several pre­ Said former NIH deputy director Dr. Thomas Malone, "I was viously unknown apolipoproteins, and uncovered new knowl­ privileged to have served as Don's deputy from 1977 through edge including descriptions concerning the structure and 198 1. Thls appointment was one of the most fulfilling during function of various apoproteins. my 20 years at NIH. Following a superb and productive pe­ Before becoming f\TJH director. he served for 1 year (1974- ri od of bench research, he made the transition to the adminis­ 1975) as president of the Institute of Medicine, National Acad­ trative sector with case and grace. He cackled head-on the emy of Sciences. He was a member of numerous professional questions generated by the new technologies. For example, societies in addition to NAS and the American Academy of he was at the center of the recombinant DNA controversy and Arts and Sciences, was honored with 10 honorary doctorates its solution. He was equally at home with science as he was and authored more than 270 publications. He left the NIH di­ with the great writers and philosophers, past and present. He rectorship lo return to NAS as a visiting scholar. was a superb writer and speaker. I shall always remember his In 1983, he joined the Howard Hughes Medical Institute as genius and wit and wi ll be forever appreciative that be passed vice president, rising Lo president and CEO inl984; he left my way." HHMI in 1987, and became a scholar at the National Library of Fredrickson was born Aug. 8. 1924. in Canon City, Colo. He Medicine. His CV notes whimsically that, for2:'l years, he was received both his B.S. (1946) and M.D. (1949) from the. Univer­ physician to King Hassan IT of Morocco. sity of Michigan, and was certified by the American Board of Burial took place in The Netherlands. He is survived by his Internal Medicine in 1957. He did postgraduate work at Peter wife, Henriette, and 1wo sons, Eric of Columbus, Ohjo, and Bent Brigham and Massachusetts General Hospitals and Rurik, an NlAID employee, of Bethesda. A memorial service Harvard Medical School prior to coming to NIH in 1953. al NIH is scheduled for Friday, Oct. 18 in Natcher Conference In that year, he joined the scientific staff of the then Na- Center. SUMMER 2 0 0 2

NIH Retrospectives: 5 Decades of History

is still flourishing and can be seen on demic of acquired immunosuppression, Center Dr. across the street from NLM] opportunistic infection, and Kaposi's -i!Hilkll ... TheAug. 28, 1962, issueoftheN/H sarcomas-a disease which began ..., . ..._..., .._...... ~u ...... Record presented changes in format. among homosexual males but is now The Record's distribution has increased affecting other segments of the from 4,800 to 11,300 ... Congress population. Since first detected 2 years Summer 1952 authorized the establishment of two ago, 485 people i11 24 states and 8 new research institutes at NIH -the foreign count:Jies have been infected. NIH is featured in the Aug. 30 issue of National Institute of Chi Id Health and There are 187 deaths in the U.S. as of Collier's magazine. The story, "They're Human Development and the National July 23. There were representatives Adding Years to Your Life," by Frank Institute of General Medical Sciences [ from each institute and Liaisons from the Holeman , is based on material gathered Both institutes celebrate their 4Q•h CDC and FDA ... To mark its 2Qlh at Nil-J. The article with illustrations anniversary this year]. anniversary the National Institute of describes the research activities of lhc General Medical Sciences is inaugurat­ institutes as well as the grants program ing an annual lectureship named in ... The NIH library has obtained a honor of Dr. De Witt Stetten, Jr. number of books on medical research written by PHS and NIH scientists. uf~1Record ...... " .':... :~:;;.· -~::. :... .., '::. ... :. ·:: ..., . .._...... -...... - Among them arc: Dr. R.C. Williams' history, "The United States Public Heath Summer 1972 Service 1798-1950," Dr. W. F. Von The NIH Record Oettingen's new treatise, "Poisoning," NIH withstood the effects of Hurricane and two books were published: Dr. Agnes nicely according to Thomas Summer 1992 Theodore Von Brand's "Chemical Cook, chief of lhe maintenance and Physiology of Endoparasitic Animals," landscaping section, Plant Engineering William Donald Schaefer recently and Dr. John R. McGibony's "Principles Branch ... In addition lo the present no­ became the first governor of Maryland of Hospital Administration" ... There smoking ban in public conference to visit NIH in an official capacity. He are peculiar stirrings in the Hamster rooms and auditoriums, a si milar visited several labs, a patient-care unit, department. With the first days of restriction has been placed in cafeteria and the Children's Inn ... In July 1992, summer comes word that plans are and work areas. The department has the Alcohol, Drug Abuse, and Mental beginning to jell for the next Hamster directed that "no-smoking areas are to Health (ADAMI-IA) Reorgani zati on show. No hints yet as to what it will be. be established in cafete1ias under Act, amended by the PHS act provides contract to DHEW in Department­ for the inclusion of three ADAMHA controlled buildings." research institutes-NIMH, NlHAA, and NIDA- into NIH effective Oct l 1992 ... Dr. Lance Liotta, chief of the ' tumor invasion and metastases section in the Laboratory of Pathology, chief of Summer 1962

t~1R~:;:'~ -::i·~ ecord~ the Laboratory of Pathology, and ...... :...... :.·:· ...,- ...... , ... - ... _ codirector of the Anatomic Pathology On Friday, May 11 a tree planting Summer 1982 Residency Program in the Laboratory of ceremony took pince on the grounds of Pathology, NCI, has been named the National Library of Medicine. The On July 6, Dr. Claude Lenfant was deputy director for intramural research tree was grown from a slip of a famous appointed director of the National effective July 6. Oriental plane tree on the Greek island of Heart, Lung and Blood Lnstiture by NIH Cos. According to legend, it was under director Dr. James B. Wyngaarden ... In this tree that Hippocrate's instructed his June an NIH working group was formed pupils in the fifth century B.C. [The tree to aid in controlling the current epi-

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