Le Syndrome D Intoxication Fongique Acromelalgien Nouvelles Avancees Scientifiques Et Creation De Fiches De Reconnaissances

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Le Syndrome D Intoxication Fongique Acromelalgien Nouvelles Avancees Scientifiques Et Creation De Fiches De Reconnaissances http://portaildoc.univ-lyon1.fr Creative commons : Paternité - Pas d’Utilisation Commerciale - Pas de Modification 2.0 France (CC BY-NC-ND 2.0) http://creativecommons.org/licenses/by-nc-nd/2.0/fr BOUVARD (CC BY-NC-ND 2.0) UNIVERSITE CLAUDE BERNARD - LYON 1 FACULTE DE PHARMACIE INSTITUT DES SCIENCES PHARMACEUTIQUES ET BIOLOGIQUES 2018 THESE n°53 T H E S E pour le DIPLOME D'ETAT DE DOCTEUR EN PHARMACIE présentée et soutenue publiquement le 12 juin 2018 par M. BOUVARD Jérémy Né le 31 juillet 1992 A Lyon 9è ***** LE SYNDROME D’INTOXICATION FONGIQUE ACROMELALGIEN : NOUVELLES AVANCEES SCIENTIFIQUES ET CREATION DE FICHES DE RECONNAISSANCES DES CHAMPIGNONS IMPLIQUES ***** JURY M. Didier BLAHA, Maitre de conférences des universités Mme Veronica RODRIGUEZ NAVA, Maitre de conférences des universités Mme Caroline PALIARD, Docteur en Pharmacie, expert en Mycologie M. Alexandre PONCHON, Docteur en Pharmacie BOUVARD (CC BY-NC-ND 2.0) UNIVERSITE CLAUDE BERNARD LYON 1 • Président de l’Université M. Frédéric FLEURY • Présidence du Conseil Académique M. Hamda BEN HADID • Vice-Président du Conseil d’Administration M. Didier REVEL • Vice-Président de la Commission Recherche M. Fabrice VALLEE • Vice-Président de la Formation et de la Vie Universitaire M. Philippe CHEVALIER Composantes de l’Université Claude Bernard Lyon 1 SANTE • UFR de Médecine Lyon Est Directeur : M. Gilles RODE • UFR de Médecine Lyon Sud Directeur : Mme Carole BURILLON Charles Mérieux • Institut des Sciences Pharmaceutiques et Directrice : Mme Christine VINCIGUERRA Biologiques • UFR d'Odontologie Directeur : M. Denis BOURGEOIS • Institut des Techniques de Directeur : M. Yves MATILLON Réadaptation • Département de formation et centre de Directeur : Anne-Marie SCHOTT Recherche en Biologie Humaine SCIENCES ET TECHNOLOGIES • Faculté des Sciences et Technologies Directeur : M. Fabien DE MARCHI • UFR de Sciences et Techniques des Directeur : M. Yannick VANPOULLE Activités Physiques et Sportives (STAPS) • Ecole Polytechnique Universitaire de Lyon Directeur : M. Pascal FOURNIER (ex ISTIL) • I.U.T. LYON 1 Directeur : M. Christophe VITON • Institut des Sciences Financières et Directeur : M. Nicolas LEBOISNE d'Assurance (ISFA) • ESPE Directeur : M. Alain MOUGNIOTTE 2 BOUVARD (CC BY-NC-ND 2.0) UNIVERSITE CLAUDE BERNARD LYON 1 ISPB -Faculté de Pharmacie Lyon LISTE DES DEPARTEMENTS PEDAGOGIQUES DEPARTEMENT PEDAGOGIQUE DE SCIENCES PHYSICO-CHIMIQUE ET PHARMACIE GALENIQUE • CHIMIE ANALYTIQUE, GENERALE, PHYSIQUE ET MINERALE Monsieur Raphaël TERREUX (Pr) Madame Julie-Anne CHEMELLE (MCU) Madame Anne DENUZIERE (MCU) Monsieur Lars-Petter JORDHEIM (MCU-HDR) Madame Christelle MACHON (MCU) • PHARMACIE GALENIQUE -COSMETOLOGIE Madame Marie-Alexandrine BOLZINGER (Pr) Madame Stéphanie BRIANCON (Pr) Madame Françoise FALSON (Pr) Monsieur Hatem FESSI (Pr) Monsieur Fabrice PIROT (PU - PH) Monsieur Eyad AL MOUAZEN (MCU) Madame Sandrine BOURGEOIS (MCU) Madame Ghania HAMDI-DEGOBERT (MCU-HDR) Monsieur Plamen KIRILOV (MCU) Madame Giovanna LOLLO (MCU) Monsieur Damien SALMON (AHU) • BIOPHYSIQUE Madame Laurence HEINRICH (MCU) Monsieur David KRYZA (MCU – PH - HDR) Madame Sophie LANCELOT (MCU - PH) Monsieur Cyril PAILLER-MATTEI (MCU-HDR) Madame Elise LEVIGOUREUX (AHU) DEPARTEMENT PEDAGOGIQUE PHARMACEUTIQUE DE SANTE PUBLIQUE • DROIT DE LA SANTE Monsieur François LOCHER (PU – PH) Madame Valérie SIRANYAN (MCU - HDR) • ECONOMIE DE LA SANTE 3 BOUVARD (CC BY-NC-ND 2.0) Madame Nora FERDJAOUI MOUMJID (MCU - HDR) Madame Carole SIANI (MCU – HDR) Monsieur Hans-Martin SPÄTH (MCU) • INFORMATION ET DOCUMENTATION Monsieur Pascal BADOR (MCU - HDR) • HYGIENE, NUTRITION, HYDROLOGIE ET ENVIRONNEMENT Madame Joëlle GOUDABLE (PU – PH) • INGENIERIE APPLIQUEE A LA SANTE ET DISPOSITIFS MEDICAUX Monsieur Gilles AULAGNER (PU – PH) Monsieur Daniel HARTMANN (Pr) • QUALITOLOGIE – MANAGEMENT DE LA QUALITE Madame Alexandra CLAYER-MONTEMBAULT (MCU) Monsieur Vincent GROS (MCU-PAST) Madame Audrey JANOLY-DUMENIL (MCU-PH) Madame Pascale PREYNAT (MCU PAST) • MATHEMATIQUES – STATISTIQUES Madame Claire BARDEL-DANJEAN (MCU-PH) Madame Marie-Aimée DRONNE (MCU) Madame Marie-Paule GUSTIN (MCU - HDR) DEPARTEMENT PEDAGOGIQUE SCIENCES DU MEDICAMENT • CHIMIE ORGANIQUE Monsieur Pascal NEBOIS (Pr) Madame Nadia WALCHSHOFER (Pr) Monsieur Zouhair BOUAZIZ (MCU - HDR) Madame Christelle MARMINON (MCU) Madame Sylvie RADIX (MCU -HDR) Monsieur Luc ROCHEBLAVE (MCU - HDR) • CHIMIE THERAPEUTIQUE Monsieur Marc LEBORGNE (Pr) Monsieur Thierry LOMBERGET (Pr) Monsieur Laurent ETTOUATI (MCU - HDR) Madame Marie-Emmanuelle MILLION (MCU) • BOTANIQUE ET PHARMACOGNOSIE Madame Marie-Geneviève DIJOUX-FRANCA (Pr) Madame Marie-Emmanuelle HAY DE BETTIGNIES (MCU) 4 BOUVARD (CC BY-NC-ND 2.0) Madame Isabelle KERZAON (MCU) Monsieur Serge MICHALET (MCU) • PHARMACIE CLINIQUE, PHARMACOCINETIQUE ET EVALUATION DU MEDICAMENT Madame Roselyne BOULIEU (PU – PH) Madame Catherine RIOUFOL (PU- PH) Madame Magali BOLON-LARGER (MCU - PH) Madame Christelle CHAUDRAY-MOUCHOUX (MCU-PH) Madame Céline PRUNET-SPANO (MCU) Madame Florence RANCHON (MCU) DEPARTEMENT PEDAGOGIQUE DE PHARMACOLOGIE, PHYSIOLOGIE ET TOXICOLOGIE • TOXICOLOGIE Monsieur Jérôme GUITTON (PU – PH) Madame Léa PAYEN (PU-PH) Monsieur Bruno FOUILLET (MCU) Monsieur Sylvain GOUTELLE (MCU-PH) • PHYSIOLOGIE Monsieur Christian BARRES (Pr) Madame Kiao Ling LIU (MCU) Monsieur Ming LO (MCU - HDR) • PHARMACOLOGIE Monsieur Michel TOD (PU – PH) Monsieur Luc ZIMMER (PU – PH) Monsieur Roger BESANCON (MCU) Monsieur Laurent BOURGUIGNON (MCU-PH) Madame Evelyne CHANUT (MCU) Monsieur Nicola KUCZEWSKI (MCU) Madame Dominique MARCEL CHATELAIN (MCU-HDR) • COMMUNICATION Monsieur Ronald GUILLOUX (MCU) • ENSEIGNANTS ASSOCIES TEMPORAIRES Monsieur Olivier CATALA (Pr-PAST) Madame Corinne FEUTRIER (MCU-PAST) Madame Mélanie THUDEROZ (MCU-PAST) 5 BOUVARD (CC BY-NC-ND 2.0) DEPARTEMENT PEDAGOGIQUE DES SCIENCES BIOMEDICALES A • IMMUNOLOGIE Monsieur Guillaume MONNERET (PU-PH) Madame Cécile BALTER-VEYSSEYRE (MCU - HDR) Madame Morgane GOSSEZ (AHU) Monsieur Sébastien VIEL (AHU) • HEMATOLOGIE ET CYTOLOGIE Madame Christine VINCIGUERRA (PU - PH) Madame Brigitte DURAND (MCU - PH) Monsieur Yohann JOURDY (AHU) • MICROBIOLOGIE ET MYCOLOGIE FONDAMENTALE ET APPLIQUEE AUX BIOTECHNOLOGIE INDUSTRIELLES Monsieur Patrick BOIRON (Pr) Monsieur Jean FRENEY (PU – PH) Monsieur Frédéric LAURENT (PU-PH-HDR) Madame Florence MORFIN (PU – PH) Monsieur Didier BLAHA (MCU) Madame Ghislaine DESCOURS (MCU-PH) Madame Anne DOLEANS JORDHEIM (MCU-PH) Madame Emilie FROBERT (MCU - PH) Madame Véronica RODRIGUEZ-NAVA (MCU-HDR) • PARASITOLOGIE, MYCOLOGIE MEDICALE Monsieur Philippe LAWTON (Pr) Madame Nathalie ALLIOLI (MCU) Madame Samira AZZOUZ-MAACHE (MCU - HDR) DEPARTEMENT PEDAGOGIQUE DES SCIENCES BIOMEDICALES B • BIOCHIMIE – BIOLOGIE MOLECULAIRE - BIOTECHNOLOGIE Madame Pascale COHEN (Pr) Madame Caroline MOYRET-LALLE (Pr) Monsieur Alain PUISIEUX (PU - PH) Madame Emilie BLOND (MCU-PH) Monsieur Karim CHIKH (MCU - PH) Madame Carole FERRARO-PEYRET (MCU - PH-HDR) Monsieur Boyan GRIGOROV (MCU) Monsieur Hubert LINCET (MCU-HDR) Monsieur Olivier MEURETTE (MCU) Madame Angélique MULARONI (MCU) Madame Stéphanie SENTIS (MCU) 6 BOUVARD (CC BY-NC-ND 2.0) Monsieur Anthony FOURIER (AHU) • BIOLOGIE CELLULAIRE Madame Bénédicte COUPAT-GOUTALAND (MCU) Monsieur Michel PELANDAKIS (MCU - HDR) • INSTITUT DE PHARMACIE INDUSTRIELLE DE LYON Madame Marie-Alexandrine BOLZINGER (Pr) Monsieur Daniel HARTMANN (Pr) Monsieur Philippe LAWTON (Pr) Madame Sandrine BOURGEOIS (MCU) Madame Marie-Emmanuelle MILLION (MCU) Madame Alexandra MONTEMBAULT (MCU) Madame Angélique MULARONI (MCU) Madame Valérie VOIRON (MCU - PAST) • Assistants hospitalo-universitaires sur plusieurs départements pédagogiques Monsieur Alexandre JANIN • Attachés Temporaires d’Enseignement et de Recherche (ATER) Monsieur Karim MILADI (85ème section) Monsieur Antoine ZILLER (87ème section) Pr : Professeur PU-PH : Professeur des Universités, Praticien Hospitalier MCU : Maître de Conférences des Universités MCU-PH : Maître de Conférences des Universités, Praticien Hospitalier HDR : Habilitation à Diriger des Recherches AHU : Assistant Hospitalier Universitaire PAST : Personnel Associé Temps Partiel 7 BOUVARD (CC BY-NC-ND 2.0) REMERCIEMENTS A Monsieur Didier BLAHA, d’avoir accepté de diriger ma thèse, et de présider mon jury. Merci de votre gentillesse, votre accessibilité, votre soutien et de m’avoir accompagné tout au long de ce travail. A Madame Veronica RODRIGUEZ NAVA, d’avoir accepté de faire partie de mon jury. A Madame Caroline PALIARD, d’avoir également dirigé ma thèse, et de faire partie de mon jury. Merci de votre soutien, vos conseils, votre expertise et de votre aide durant tout ce travail. A Monsieur Alexandre PONCHON, d’avoir accepté de faire partie de mon jury de thèse. Au plaisir de se retrouver autour d’une bière avec la famille VPI. A mes parents, à mon frère. Merci de m’avoir toujours soutenu, toujours encouragé, écouté et aidé dans mes choix. D’être toujours là pour moi, de m’accompagner et d’avoir fait de moi ce que je suis aujourd’hui. Je vous remercie du fond du cœur, je vous aime, je vous dois tout. A toute ma famille. À papy Deryck, qui me regarde de là-haut. Merci à vous tous de m’avoir toujours soutenu et encouragé. Je vous aime. A Laure, mon étoile à l’infini. A tous mes amis pharma, tous mes amis, pour leur soutien, tous ces moments et qui sont toujours là. Je souhaite qu’il y ait encore pleins de bons moments avec vous. A mon burô de l’AAEPL, aux anciens de l’Amicale, à la famille VPI, pour tous ces moments de vie associative qui m’ont aidé à devenir ce que je suis. Merci
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