Safety data sheet
Page: 1/15 BASF Safety data sheet according to UN GHS 4th rev. Date / Revised: 12.06.2018 Version: 1.2 Product: Lupro-Grain® (ID no. 30062123/SDS_GEN_00/EN) Date of print 13.06.2018
1. Identification Product identifier
Lupro-Grain®
Relevant identified uses of the substance or mixture and uses advised against
Relevant identified uses: feed additive(s)
Details of the supplier of the safety data sheet
Company: BASF SE 67056 Ludwigshafen GERMANY Operating Division Nutrition and Health
Telephone: +49 621 60-48434 E-mail address: [email protected]
Emergency telephone number
International emergency number: Telephone: +49 180 2273-112
2. Hazards Identification
Classification of the substance or mixture
According to UN GHS criteria
Flam. Liq. 4 Acute Tox. 5 (oral) Acute Tox. 5 (dermal) Skin Corr./Irrit. 2
Page: 2/15 BASF Safety data sheet according to UN GHS 4th rev. Date / Revised: 12.06.2018 Version: 1.2 Product: Lupro-Grain® (ID no. 30062123/SDS_GEN_00/EN) Date of print 13.06.2018 Eye Dam./Irrit. 1 STOT SE 3 (irritating to respiratory system)
For the classifications not written out in full in this section the full text can be found in section 16.
Label elements
Globally Harmonized System (GHS)
Pictogram:
Signal Word: Danger
Hazard Statement: H227 Combustible liquid. H318 Causes serious eye damage. H315 Causes skin irritation. H313 May be harmful in contact with skin. H303 May be harmful if swallowed. H335 May cause respiratory irritation.
Precautionary Statements (Prevention): P280 Wear protective gloves and eye/face protection. P271 Use only outdoors or in a well-ventilated area. P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash with plenty of water and soap thoroughly after handling.
Precautionary Statements (Response): P310 Immediately call a POISON CENTER or doctor/physician. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304 + P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P303 + P352 IF ON SKIN (or hair): Wash with plenty of soap and water. P362 + P364 Take off contaminated clothing and wash it before reuse. P370 + P378 In case of fire: Use alcohol-resistant foam, carbon dioxide, dry powder or water spray for extinction.
Precautionary Statements (Storage): P233 Keep container tightly closed. P403 + P235 Store in a well-ventilated place. Keep cool. P405 Store locked up.
Page: 3/15 BASF Safety data sheet according to UN GHS 4th rev. Date / Revised: 12.06.2018 Version: 1.2 Product: Lupro-Grain® (ID no. 30062123/SDS_GEN_00/EN) Date of print 13.06.2018 Precautionary Statements (Disposal): P501 Dispose of contents/container to hazardous or special waste collection point.
According to UN GHS criteria
Hazard determining component(s) for labelling: propionic acid...%
Other hazards
According to UN GHS criteria
If applicable information is provided in this section on other hazards which do not result in classification but which may contribute to the overall hazards of the substance or mixture. The product does not contain a substance fulfilling the PBT (persistent/bioaccumulative/toxic) criteria or the vPvB (very persistent/very bioaccumulative) criteria.
3. Composition/Information on Ingredients Substances
Not applicable
Mixtures
Chemical nature
Preparation based on: propionic acid...%, Ammonium propionate, propane-1,2-diol, Water
Hazardous ingredients (GHS) According to UN GHS criteria
propionic acid...% Content (W/W): >= 50 % - < 75 % Flam. Liq. 3 CAS Number: 79-09-4 Acute Tox. 5 (oral) EC-Number: 201-176-3 Acute Tox. 5 (dermal) Skin Corr./Irrit. 1B Eye Dam./Irrit. 1 STOT SE 3 (irr. to respiratory syst.) H226, H313, H303, H335, H314
Specific concentration limit: STOT SE 3, irr. to respiratory syst.: >= 10 % Skin Corr./Irrit. 2: 10 - < 25 % Eye Dam./Irrit. 2: 10 - < 25 % Skin Corr./Irrit. 1B: >= 25 %
Page: 4/15 BASF Safety data sheet according to UN GHS 4th rev. Date / Revised: 12.06.2018 Version: 1.2 Product: Lupro-Grain® (ID no. 30062123/SDS_GEN_00/EN) Date of print 13.06.2018 For the classifications not written out in full in this section the full text can be found in section 16.
4. First-Aid Measures Description of first aid measures First aid personnel should pay attention to their own safety. If the patient is likely to become unconscious, place and transport in stable sideways position (recovery position). Immediately remove contaminated clothing.
If inhaled: Keep patient calm, remove to fresh air, seek medical attention. Immediately administer a corticosteroid from a controlled/metered dose inhaler.
On skin contact: Immediately wash thoroughly with plenty of water, apply sterile dressings, consult a skin specialist.
On contact with eyes: Immediately wash affected eyes for at least 15 minutes under running water with eyelids held open, consult an eye specialist.
On ingestion: Immediately rinse mouth and then drink 200-300 ml of water, seek medical attention.
Most important symptoms and effects, both acute and delayed Symptoms: The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11.
Indication of any immediate medical attention and special treatment needed Treatment: Treat according to symptoms (decontamination, vital functions), no known specific antidote.
5. Fire-Fighting Measures Extinguishing media Suitable extinguishing media: water spray, carbon dioxide, dry powder, alcohol-resistant foam
Unsuitable extinguishing media for safety reasons: water jet
Special hazards arising from the substance or mixture carbon oxides, harmful vapours The substances/groups of substances mentioned can be released in case of fire.
Advice for fire-fighters Special protective equipment:
Page: 5/15 BASF Safety data sheet according to UN GHS 4th rev. Date / Revised: 12.06.2018 Version: 1.2 Product: Lupro-Grain® (ID no. 30062123/SDS_GEN_00/EN) Date of print 13.06.2018 Wear a self-contained breathing apparatus.
Further information: Dispose of fire debris and contaminated extinguishing water in accordance with official regulations. Cool endangered containers with water-spray.
6. Accidental Release Measures Personal precautions, protective equipment and emergency procedures Wear suitable protective clothing. Avoid contact with the skin, eyes and clothing. Do not breathe vapour/spray. Ensure adequate ventilation. Avoid all sources of ignition: heat, sparks, open flame. Wear respiratory protection if ventilation is inadequate. Information regarding personal protective measures see, section 8.
Environmental precautions Do not discharge into drains/surface waters/groundwater.
Methods and material for containment and cleaning up For small amounts: Pick up with suitable absorbent material (e.g. acid binder). For large amounts: Dike spillage. Cover with blanket of foam (alcohol-resistant foam). Pump off product. For residues: Pick up with suitable absorbent material (e.g. acid binder). Dispose of absorbed material in accordance with regulations. Cleaning operations should be carried out only while wearing breathing apparatus.
7. Handling and Storage Precautions for safe handling Ensure thorough ventilation of stores and work areas. Wear suitable protective clothing and eye/face protection. Avoid contact with the skin, eyes and clothing. Keep container tightly sealed.
Protection against fire and explosion: Take precautionary measures against static discharges. Avoid all sources of ignition: heat, sparks, open flame. If exposed to fire, keep containers cool by spraying with water.
Conditions for safe storage, including any incompatibilities Segregate from alkalies and alkalizing substances.
Suitable materials for containers: Stainless steel 1.4401, Stainless steel 1.4301 (V2), High density polyethylene (HDPE), Aluminium, Low density polyethylene (LDPE) Further information on storage conditions: Keep container tightly closed and dry; store in a cool place.
Specific end use(s) For the relevant identified use(s) listed in Section 1 the advice mentioned in this section 7 is to be observed.
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8. Exposure Controls/Personal Protection Control parameters
Components with occupational exposure limits
57-55-6: Propane-1,2-diol 79-09-4: propionic acid...%
Exposure controls Personal protective equipment Respiratory protection: Wear respiratory protection if ventilation is inadequate. Gas filter for gases/vapours of organic compounds (boiling point >65 °C, e. g. EN 14387 Type A)
Hand protection: Wear chemical resistant protective gloves. butyl rubber (butyl) - 0.7 mm coating thickness chloroprene rubber (Neoprene) Supplementary note: The specifications are based on tests, literature data and information of glove manufacturers or are derived from similar substances by analogy. Due to many conditions (e.g. temperature) it must be considered, that the practical usage of a chemical-protective glove in practice may be much shorter than the permeation time determined through testing.
Eye protection: Tightly fitting safety goggles (splash goggles) (e.g. EN 166)
Body protection: Body protection must be chosen depending on activity and possible exposure, e.g. apron, protecting boots, chemical-protection suit (according to EN 14605 in case of splashes or EN ISO 13982 in case of dust).
General safety and hygiene measures Handle in accordance with good industrial hygiene and safety practice. Wearing of closed work clothing is required additionally to the stated personal protection equipment. Avoid contact with the skin, eyes and clothing. Do not inhale gases/vapours/aerosols. Hands and/or face should be washed before breaks and at the end of the shift. No eating, drinking, smoking or tobacco use at the place of work. Store work clothing separately. Handle in accordance with good industrial hygiene and safety practice.
9. Physical and Chemical Properties Information on basic physical and chemical properties
Form: liquid Colour: colourless to yellowish
Page: 7/15 BASF Safety data sheet according to UN GHS 4th rev. Date / Revised: 12.06.2018 Version: 1.2 Product: Lupro-Grain® (ID no. 30062123/SDS_GEN_00/EN) Date of print 13.06.2018 Odour: pungent Odour threshold: Not determined due to potential health hazard by inhalation. pH value: 4,2 - 4,8 (measured with the undiluted substance) crystallization temperature: -29,5 °C Boiling range: 143 - 211 °C Flash point: 62,5 °C (DIN 51755) Evaporation rate: not determined Flammability: Combustible liquid. Lower explosion limit: For liquids not relevant for classification and labelling., The lower explosion point may be 5 - 15 °C below the flash point. Upper explosion limit: For liquids not relevant for classification and labelling. Ignition temperature: 455 °C Vapour pressure: 2 hPa (measured) (20 °C) 18 hPa (measured) (50 °C) Density: approx. 1,031 g/cm3 (pyknometer) (20 °C) Relative density: approx. 1,03 (20 °C) Relative vapour density (air): not determined Solubility in water: fully soluble Partitioning coefficient n-octanol/water (log Kow): not applicable for mixtures Information on: propionic acid...% Partitioning coefficient n-octanol/water (log Kow): 0,33 (measured) Literature data. Information on: propane-1,2-diol Partitioning coefficient n-octanol/water (log Kow): -1,07 (Directive 92/69/EEC, A.8) (20,5 °C; pH value: 6,2 - 6,4) ------Thermal decomposition: not determined Viscosity, dynamic: 13,7 mPa.s (20 °C) Viscosity, kinematic: 10,6 mm2/s (20 °C) Explosion hazard: Based on the chemical structure there is no indicating of explosive properties.
Page: 8/15 BASF Safety data sheet according to UN GHS 4th rev. Date / Revised: 12.06.2018 Version: 1.2 Product: Lupro-Grain® (ID no. 30062123/SDS_GEN_00/EN) Date of print 13.06.2018 Fire promoting properties: Based on its structural properties the product is not classified as oxidizing. Grain size distribution: The substance / product is marketed or used in a non solid or granular form.
10. Stability and Reactivity Reactivity No hazardous reactions if stored and handled as prescribed/indicated.
Corrosion to metals: The product is not to be labelled as corrosive for transport purposes. The product has not been tested. The statement has been derived from substances/products of a similar structure or composition.
Possibility of hazardous reactions No hazardous reactions if stored and handled as prescribed/indicated.
Conditions to avoid Avoid all sources of ignition: heat, sparks, open flame. See MSDS section 7 - Handling and storage.
Incompatible materials
Substances to avoid: strong alkalies
Hazardous decomposition products
Hazardous decomposition products: No hazardous decomposition products if stored and handled as prescribed/indicated.
11. Toxicological Information Information on toxicological effects
Acute toxicity
Assessment of acute toxicity: Of low toxicity after single ingestion. Of low toxicity after short-term skin contact. The product has not been tested. The statement has been derived from the properties of the individual components.
Information on: propionic acid...%
Experimental/calculated data: LD50 rat (oral): 3.455 mg/kg (BASF-Test)
Information on: Ammonium propionate
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Experimental/calculated data: LD50 rat (oral): 2.000 - 5.000 mg/kg (BASF-Test) ------
Information on: propionic acid...% Experimental/calculated data: LD50 rat (dermal): 3.235 mg/kg (other) ------
Irritation
Assessment of irritating effects: Skin contact causes irritation. May cause severe damage to the eyes.
Experimental/calculated data: Skin corrosion/irritation rabbit: Irritant. (OECD Guideline 404) The product has not been tested. The statement has been derived from substances/products of a similar structure or composition.
Serious eye damage/irritation cattle: irreversible damage (BCOP) Tested as a preparation.
Respiratory/Skin sensitization
Assessment of sensitization: Skin sensitizing effects were not observed in animal studies. The product has not been tested. The statement has been derived from the properties of the individual components.
Information on: propionic acid...% Experimental/calculated data: Guinea pig maximization test guinea pig: Non-sensitizing. (OECD Guideline 406) The product has not been tested. The statement has been derived from substances/products of a similar structure or composition.
Information on: Ammonium propionate Experimental/calculated data: Guinea pig maximization test guinea pig: Non-sensitizing. (OECD Guideline 406)
Information on: propane-1,2-diol Experimental/calculated data: Guinea pig maximization test guinea pig: Non-sensitizing. ------
Germ cell mutagenicity
Assessment of mutagenicity: Based on available Data, the classification criteria are not met.
Information on: propionic acid...%
Page: 10/15 BASF Safety data sheet according to UN GHS 4th rev. Date / Revised: 12.06.2018 Version: 1.2 Product: Lupro-Grain® (ID no. 30062123/SDS_GEN_00/EN) Date of print 13.06.2018 Assessment of mutagenicity: Results from a number of mutagenicity studies with microorganisms, mammalian cell culture and mammals are available. Taking into account all of the information, there is no indication that the substance is mutagenic. The product has not been fully tested. The statements have been derived in parts from products of a similar structure or composition.
Information on: Ammonium propionate Assessment of mutagenicity: The substance was not mutagenic in bacteria. The chemical structure does not suggest a specific alert for such an effect.
Information on: propane-1,2-diol Assessment of mutagenicity: No mutagenic effect was found in various tests with bacteria and mammalian cell culture. The substance was not mutagenic in studies with mammals. ------
Carcinogenicity
Assessment of carcinogenicity: Based on available Data, the classification criteria are not met.
Information on: propionic acid...% Assessment of carcinogenicity: In long-term animal studies in which the substance was given in high concentrations by feed, a carcinogenic effect was not observed.
Information on: propane-1,2-diol Assessment of carcinogenicity: In long-term animal studies in which the substance was given in high doses by feed, a carcinogenic effect was not observed. ------
Reproductive toxicity
Assessment of reproduction toxicity: Based on available Data, the classification criteria are not met.
Information on: propionic acid...% Assessment of reproduction toxicity: The results of animal studies gave no indication of a fertility impairing effect.
Information on: propane-1,2-diol Assessment of reproduction toxicity: The results of animal studies gave no indication of a fertility impairing effect. ------
Developmental toxicity
Assessment of teratogenicity: Based on available Data, the classification criteria are not met.
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Information on: propionic acid...% Assessment of teratogenicity: No indications of a developmental toxic / teratogenic effect were seen in animal studies. The product has not been tested. The statement has been derived from substances/products of a similar structure or composition.
Information on: propane-1,2-diol Assessment of teratogenicity: No indications of a developmental toxic / teratogenic effect were seen in animal studies. ------
Specific target organ toxicity (single exposure)
Assessment of STOT single: Causes temporary irritation of the respiratory tract.
Remarks: The product has not been tested. The statement has been derived from the properties of the individual components.
Repeated dose toxicity and Specific target organ toxicity (repeated exposure)
Assessment of repeated dose toxicity: After repeated exposure the prominent effect is local irritation. The product has not been tested. The statement has been derived from the properties of the individual components.
Information on: propionic acid...% Assessment of repeated dose toxicity: No substance-specific organtoxicity was observed after repeated administration to animals. After repeated administration the prominent effect is the induction of corrosion.
Information on: Ammonium propionate Assessment of repeated dose toxicity: No data available.
Information on: propane-1,2-diol Assessment of repeated dose toxicity: Repeated oral uptake of the substance did not cause substance-related effects. ------
Aspiration hazard
No aspiration hazard expected.
12. Ecological Information Toxicity
Assessment of aquatic toxicity:
Page: 12/15 BASF Safety data sheet according to UN GHS 4th rev. Date / Revised: 12.06.2018 Version: 1.2 Product: Lupro-Grain® (ID no. 30062123/SDS_GEN_00/EN) Date of print 13.06.2018 There is a high probability that the product is not acutely harmful to aquatic organisms. The ecotoxicological effects are solely caused by the pH. The inhibition of the degradation activity of activated sludge is not anticipated when introduced to biological treatment plants in appropriate low concentrations.
Persistence and degradability
Assessment biodegradation and elimination (H2O): Product is expected to be readily biodegradable. Easily eliminated from water.
Elimination information: approx. 95 % (10,000000 d) (Directive 88/302/EEC, part C, p. 99) (aerobic, activated sludge)
Bioaccumulative potential
Assessment bioaccumulation potential: Significant accumulation in organisms is not to be expected. The product has not been tested. The statement has been derived from the properties of the individual components.
Mobility in soil
Assessment transport between environmental compartments: Volatility: The substance will not evaporate into the atmosphere from the water surface. Adsorption in soil: Adsorption to solid soil phase is not expected. The product has not been tested. The statement has been derived from the properties of the individual components.
Results of PBT and vPvB assessment
According to Annex XIII of Regulation (EC) No.1907/2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH): The product does not contain a substance fulfilling the PBT (persistent/bioaccumulative/toxic) criteria or the vPvB (very persistent/very bioaccumulative) criteria. Self classification
Other adverse effects
The product does not contain substances that are listed in Regulation (EC) 1005/2009 on substances that deplete the ozone layer.
13. Disposal Considerations
Waste treatment methods
Observe national and local legal requirements.
Page: 13/15 BASF Safety data sheet according to UN GHS 4th rev. Date / Revised: 12.06.2018 Version: 1.2 Product: Lupro-Grain® (ID no. 30062123/SDS_GEN_00/EN) Date of print 13.06.2018 14. Transport Information
Land transport
ADR Not classified as a dangerous good under transport regulations UN number: Not applicable UN proper shipping name: Not applicable Transport hazard class(es): Not applicable Packing group: Not applicable Environmental hazards: Not applicable Special precautions for None known user
RID Not classified as a dangerous good under transport regulations UN number: Not applicable UN proper shipping name: Not applicable Transport hazard class(es): Not applicable Packing group: Not applicable Environmental hazards: Not applicable Special precautions for None known user
Inland waterway transport ADN Not classified as a dangerous good under transport regulations UN number: Not applicable UN proper shipping name: Not applicable Transport hazard class(es): Not applicable Packing group: Not applicable Environmental hazards: Not applicable Special precautions for None known user:
Transport in inland waterway vessel Not evaluated
Sea transport
IMDG Not classified as a dangerous good under transport regulations UN number: Not applicable UN proper shipping name: Not applicable
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Air transport
IATA/ICAO Not classified as a dangerous good under transport regulations UN number: Not applicable UN proper shipping name: Not applicable Transport hazard class(es): Not applicable Packing group: Not applicable Environmental hazards: Not applicable Special precautions for None known user
Transport in bulk according to Annex II of MARPOL and the IBC Code Regulation: Not evaluated Shipment approved: Not evaluated Pollution name: Not evaluated Pollution category: Not evaluated Ship Type: Not evaluated
15. Regulatory Information Safety, health and environmental regulations/legislation specific for the substance or mixture
If other regulatory information applies that is not already provided elsewhere in this safety data sheet, then it is described in this subsection.
16. Other Information
Any other intended applications should be discussed with the manufacturer. Corresponding occupational protection measurements must be followed.
Full text of classifications, hazard symbols and hazard statements, if mentioned in section 2 or 3: Flam. Liq. Flammable liquids Acute Tox. Acute toxicity Skin Corr./Irrit. Skin corrosion/irritation Eye Dam./Irrit. Serious eye damage/eye irritation STOT SE Specific target organ toxicity — single exposure
Page: 15/15 BASF Safety data sheet according to UN GHS 4th rev. Date / Revised: 12.06.2018 Version: 1.2 Product: Lupro-Grain® (ID no. 30062123/SDS_GEN_00/EN) Date of print 13.06.2018 H226 Flammable liquid and vapour. H313 May be harmful in contact with skin. H303 May be harmful if swallowed. H335 May cause respiratory irritation. H314 Causes severe skin burns and eye damage.
The data contained in this safety data sheet are based on our current knowledge and experience and describe the product only with regard to safety requirements. This safety data sheet is neither a Certificate of Analysis (CoA) nor technical data sheet and shall not be mistaken for a specification agreement. Identified uses in this safety data sheet do neither represent an agreement on the corresponding contractual quality of the substance/mixture nor a contractually designated use. It is the responsibility of the recipient of the product to ensure any proprietary rights and existing laws and legislation are observed.
Vertical lines in the left hand margin indicate an amendment from the previous version.