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JOURNAL OF VIROLOGY VOLUME 57 * MARCH 1986 * NUMBER 3 Arnold J. Levine, Editor in Chief Michael B. A. Oldstone, Editor (1988) (1989) Scripps Clinic & Research Foundation Princeton University La Jolla, Calif. Princeton, N.J. Thomas E. Shenk, Editor (1989) David T. Denhardt, Editor (1987) Princeton University University of Western Ontario Princeton, N.J. London, Ontario, Canada Anna Marie Skalka, Editor (1989) Bernard N. Fields, Editor (1988) Hoffmann-La Roche Inc. Harvard Medical School Nutley, N.J. Boston, Mass. Robert A. Weisberg, Editor (1988) Robert M. Krug, Editor (1987) National Institute of Child Health Sloan-Kettering Institute and Human Development New York, N.Y. Bethesda, Md. EDITORIAL BOARD James Alwine (1988) Hidesaburo Hanafusa (1986) Lois K. Miller (1988) Priscilla A. Schaffer (1987) David Baltimore (1987) William S. Hayward (1987) Peter Model (1986) Sondra Schlesinger (1986) Tamar Ben-Porat (1987) Roger Hendrix (1987) Bernard Moss (1986) Schubert (1988) Kenneth I. Berns (1988) Martin Hirsch (1986) Fred Murphy (1986) June R. Scott (1986) Michael Botchan (1986) John J. Holland (1987) Opendra Narayan (1988) Bart Sefton (1988) Thomas J. Braciale (1988) Ian H. Holmes (1986) Joseph R. Nevins (1988) Charles J. Sherr (1987) Joan Brugge (1988) Robert W. Honess (1986) Nancy G. Nossal (1987) Saul J. Silverstein Barrie J. Carter (1987) Nancy Hopkins (1986) Abner Notkins (1986) (1988) John M. Coffin (1986) Peter M. Howley (1987) J. Thomas Parsons (1986) Patricia G. Spear (1987) Geoffrey M. Cooper (1987) Alice S. Huang (1987) Ulf G. Pettersson (1986) Nat Sternberg (1986) Donald Court (1987) Steve Hughes (1988) Lennart Philipson (1987) Bruce Stillman (1988) Richard Courtney (1986) Tony Hunter (1986) Lewis I. Pizer (1987) Mark F. Stinski (1986) Clyde S. Crumpacker II Jack ]. Keene (1988) Craig R. Pringle (1986) James Strauss (1987) (1988) Thon&as J. Kelly, Jr. (1988) Carol Prives (1986) F. William Studier (1987) Thomas Curran (1988) George Khoury (1987) Robert Purcell (1986) Lawrence S. Sturman (1988) Walter Doerfler (1986) Elliott Kieff (1987) R. Frank Ramig (1988) William Summers (1988) Peter Doherty (1986) David Knipe (1988) Fred Rapp (1987) John M. Taylor (1987) Elvera Ehrenfeld (1986) Daniel Kolakofsky (1986) Dan S. Ray (1986) Howard M. Temin (1988) Robert N. Eisenman (1988) Michael Lai (1988) Gordon M. Ringold (1987) George F. Vande Woude (1986) Suzanne U. Emerson (1986) Robert Lamb (1988) Harriet Robinson (1988) Inder Verma (1986) Ellen Fanning (1988) Robert A. Lazzarini (1987) William S. Robinson (1986) Edward K. Wagner (1986) Emanuel (1987) Myron Levine (1988) Bernard Roizman (1988) Raymond M. Welsh, Jr. (1988) S. Jane Flint (1987) Maxine Linial (1988) John K. Rose (1988) Gail Wertz (1988) Donald Ganem (1988) Douglas R. Lowy (1986) Naomi Rosenberg (1986) Reed B. Wickner (1988) Costa Georgopolous (1986) Robert Martin (1987) Roland R. Rueckert (1988) Eckard Wimmer (1988) Walter Gerhard (1986) Warren Masker (1987) Norman P. Salzman (1987) Owen Witte (1986) Stephen P. Goff (1988) Thomas Merigan (1986) Joseph Sambrook (1988) Charles Hamish Young (1986) Larry M. Gold (1988) George Miller (1987) Charles E. Samuel (1986) Julius S. Youngner (1986) Helen R. Whiteley, Chairman, Publications Board Linda M. Illig, Managing Editor, Journals Judith Nedrow, Production Editor The Journal of Virology (ISSN 0022-538X), a publication of the American Society for Microbiology, 1913 I St., NW, Washington, DC 20006, is devoted to the dissemination offundamental knowledge concerning of , , and . Investigators are invited to submit reports of original research in all areas of basic virology, including biochemistry, biophysics, genetics, immunology, morphology, physiology, and pathogenesis and immunity. Instructions to authors are published in the January issue each year; reprints are available from the editors and the Publications Department. The Journal is issued monthly, four volumes per year. The nonmember subscription price is $285 per year; single copies are $21. The member subscription price is $41 (foreign, $54 [surface rate]) per year; single copies are $7.00. Correspondence relating to subscriptions, reprints, defective copies, availability of back issues, lost or late proofs, disposition of submitted manuscripts, and general editorial matters should be directed to the ASM Publications Department, 1913 I St., NW, Washington, DC 20006 (phone: 202 833-9680). Claims for missing issues from residents of the United States, Canada, and Mexico must be submitted within 3 months after publication of the issues; residents of all other countries must submit claims within 6 months of publication of the issues. Claims for issues missing because offailure to report an address change or for issues "missing from files" will not be allowed. Second-class postage paid at Washington, DC 20006, and at additional mailing offices. POSTMASTER: Send address changes to Journal of Virology, ASM, 1913 I St., NW, Washington, DC 20006. Made in the U.S.A. Copyright © 1986, American Society for Microbiology. a*: 1I%#t, ( I IJ t All Rights Reserved. The code at the top of the first page of an article in this journal indicates the copyright owner's consent that copies of the arti- cle may be made for personal use or for personal use of specific clients. This consent is given on the condition, however, that the copier pay the stated per-copy fee through the Copyright Clearance Center, 21 Congress St., Salem, MA 01970, for copying beyond that permitted by Sections 107 and 108 of the U.S. Copyright Law. This consent does not extend to other kinds of copying, such as copying for general distribution, for advertising or promotional purposes, for creating new collective works, or for resale. Author Index

Almond, Jeffrey W., 1187 Forghani, Bagher, 1195 Levantis, Pedros, 907 Schoenmakers, Harrie, 1037 Arias, Carlos F., 1207 Frenkel, Niza, 933 Li, Yen, 1065, 1073 Seifert, Jan-Marcus, 1084 Ariga, Hiroyoshi, 792 Fukai, Konosuke, 1113 Long, Le, 1198 Seriburi, Orrawadee, 1113 Arnheiter, Heinz, 922 Fukui, Yasuhisa, 792 L6pez, Susana, 1207 Shimizu, Norio, 1016 Aubert, Christine, 992 Lowy, Arthur, 1048 Shiroki, Kazuko, 792 Gahmberg, Nina, 899 Lucher, Lynne A., 839, 848 Silagi, Selma, 1048 Bacchetti, S., 1177 Galloway, Denise A., 802 Luria, Sylvia, 998 Simmons, Daniel T., 776 Barkas, Alexander E., 1073 Garreis-Wabnitz, Christine, Smith, Geoffrey L., 786 Baskar, John F., 1149 968 Makino, Shinji, 729 Smythers, Gary W., 826 Bauer, Eva, 1084 Gattoni-Celli, S., 1119 Marrero, Robert, 1145 Sodroski, Joseph G., 738 Baumann, Raymond P., 816 Geballe, Adam P., 864 Marshall, R. L., 745 Springer, Timothy A., 952 Bechade, C., 1191 Ghysdael, Jacques, 1198 Martin, P., 1191 Sriskantha, A., 1004 Beck, Ewald, 983 Gilden, Donald, 1195 Mathews, Michael B., 765 Staczek, John, 816 Begue, A., 1191 Gillespie, David A. F., 907 McClure, Marcella A., 917 Stanat, Sylvia C., 1149 Bennink, Jack R., 786 Gonze, Martine, 1198 McCorquodale, D. James, 875 Stanway, Glyn, 1187 Besemer, Juergen, 1084 Gordon, Siamon, 952 McCorquodale, Maureen M., Stavnezer, Edward, 1065, Beug, H., 1127 Graeve, Lutz, 968 875 1073 Bhat, Bheem M., 1155 Green, Kim Y., 893 Melief, Cees, 1037 Stec, David S., 715 Bissell, Mina J., 907 Green, Maurice, 839, 848 Meulemans, Guy, 1198 Stehelin, D., 1191 Blair, Edward D., 1023 Grodzicker, Terri, 765 Minor, Philip D., 1187 Sternglanz, Rolf, 875 Blaisdell, Peter W., 759 Grose, Charles, 1195 Mocarski, Edward S., 864 Stillman, Bruce W., 883 Bodnar, John W., 1094 Gurney, Elizabeth G., 1168 Moran, Elizabeth, 765 Stohlman, Stephen A., 729 Brackmann, Karl H., 848 Moran, Myriam G., 1113 Strebel, Klaus, 983 Brahic, Michel, 992 Harada, Shinji, 1159 Moreno-L6pez, Jorge, 1173 Strohmaier, Karl, 983 Breindl, Michael, 968 Hart, Kevin, 907 Morner, Torsten, 1173 Sullivan, Donna C., 816 Brennan, Lynn A., 1073 Haseltine, William A., 738 Moss, Bernard, 786 Swain, Margaret A., 802 Brodeur, David, 1073 Hatanaka, Masakazu, 1159 Muirhead, B., 1177 Symington, Janey S., 839, 848 Bruenn, J. A., 754 Hayashi, Kozaburo, 942 Murphy, Brian R., 721 Bums, Mary C., 1182 Hayman, M. J., 1127 Takada, Kenzo, 1016 Burny, Arsene, 1198 Hayward, Anthony R., 976 Nemeroff, M. E., 754 Tamowski, Susan, 1168 Hemming, Val G., 721 Teumer, Jeffrey K., 1065 Calothy, C., 1191 Hengartner, Hans, 1139 O'Callaghan, Dennis J., 816 Thompson, Richard L., 1023 Cardosa, M. Jane, 952 Henry, C., 1191 Odenwald, Ward F., 922 Tibbetts, Clark, 1055 Cerny, Andreas, 1139 Hirsch, Stan, 952 Ogra, Pearay L., 1203 Turck, Claudette Magarian, Chamorro, Mario, 992 Horowitz, Mia, 998 Ohshima, Kiyoshi, 792 1065 Chanock, Robert M., 721 Horswood, Robert L., 721 Ono, Yasushi, 1016 Charan, Shiv, 1139 Horzinek, Marian C., 1010 Ooka, Tadamasa, 1105 Vafai, Abbas, 1195 Chen, Tsai-E, 1048 Hosaka, Yasuhiro, 1113 Oroszlan, Stephen, 826 van der Zeijst, Bernard A. Chow, Marie, 1094 Hsiao, W.-L. W., 1119 M., 1010 Chowdhury, Rukhsana, 960 Huang, Eng-Shang, 1149 Perrault, Jacques, 917 Vennstrom, B., 1127 Clark, Steven, 1182 Huegin, Ambros W., 1139 Pettersson, Ralf F., 899 Verderame, Michael F., 857 Cole, Gerald A., 715 Hughes, Pamela J., 1187 Pettersson, Ulf, 848, 1173 Virtanen, Anders, 848 Constantinou, Andreas, 875 Hunter-Laszlo, Mary, 976 Pintel, David, 1163 Voelkel-Meiman, Karen, 875 Copeland, Terry D., 826 Pinter, Abraham, 1048 Wach, M. P., 1004 Cortez, Nenita G., 1048 Iwasaki, Yazo, 942 Pollack, Robert, 857 Waddell, Anna, 715 Costa, Robert H., 1023 Polvino-Bodnar, Maryellen, Wagner, Edward K., 1023 Cuypers, Theo, 1037 Jacobs, Liesbeth, 1010 1094 Walsh, Edward E., 721 Jenson, A. Bennett, 721 Porterfield, James S., 952 Ward, David C., 1094 Daillie, Jacques, 1105 Jerkofsky, MaryAnn, 809 Portetelle, Daniel, 1198 Warner, Huber R., 759 Das, Jyotirmoy, 960 Jones, Stephen N., 1055 Prelich, Gregory, 883 Weinberg, David H., 833 Davison, Andrew J., 1195 Prince, Gregory A., 721 Weinstein, I. B., 1119 Debuire, B., 1191 Katoh, lyoko, 826 Werner, Fred-Jochen, 1084 de Goede, Ruud, 1037 Keck, James G., 729 Quint, Wim, 1037 Werner, Gudrun, 1084 Deiss, Louis P., 933 Keller, Paul Malcolm, 1195 Westrop, Gareth D., 1187 Deppert, Wolfgang, 1168 Keranen, Sirkka, 899 Radaszkiewicz, Thaddaus, Witte, Owen N., 1182 De Siervo, August J., 809 Ketner, Gary, 833 1037 Wold, William S. M., 1155 de The, Guy, 1105 Kettman, Richard, 738 Raines, M. B., 1127 Wong, David T., 1203 de Turenne-Tessier, Mireille, Kikukawa, Ronko, 1159 Roberts, Richard J., 765 Wroblewska, Zofia, 1195 1105 Kobayashi, Nobuyuki, 1159 Rodriguez, L. L., 745 Wyke, John A., 907 Devi-Rao, Gayathri, 1023 Konopka, James B., 1182 Romaine, C. P., 1004 Dorsett, Preston H., 893 Koyanagi, Yoshio, 1159 Rosen, Craig A., 738 Yamamoto, Naoki, 1159 Draper, Kenneth G., 1023 Kruppa, Joachim, 968 Rosenberg, Naomi, 1182 Yamanishi, Koichi, 1195 Dubois-Dalcq, Monique, 922 Kuismanen, Esa, 899 Rosenwirth, Brigitte, 1084 Yanagi, Kazuo, 942 Dunn, Glynis, 1187 Kung, H. J., 1127 Yasbin, Ronald E., 1145 Sakuma, Sadatoshi, 1016 Yasuda, Yuko, 1113 Edson, Clark M., 1195 Labieniec-Pintel, Laura, 1163 Saule, S., 1191 Yewdell, Jonathan W., 786 Ellis, Ronald W., 1195 Lai, Michael M. C., 729 Schaller, Heinz, 983 Yoshinaka, Yoshiyuki, 826 Espejo, Romilio T., 1207 Larsen, Pamela L., 1055 Schiff-Maker, Leslie, 1182 Evans, David M. A., 1187 Lazzarini, Robert A., 922 Schild, Geoffrey C., 1187 Zauke, Michael, 968 Evelegh, M. J., 1177 Leach, Fredrick S., 864 Schlagnhaufer, B., 1004 Zerler, Brad, 765 Leibson, Paul J., 976 Schmaljohn, Alan L., 715 Zijlstra, Maarten, 1037 Ferre, F., 1191 Letchworth, G. J., III, 745 Schmaljohn, Connie S., 715 Zinkernagel, Rolf M., 1139 AUTHOR INDEX VOLUME 57

Aasted, Bent, 285 Burny, Arsene, 1198 Draper, Kenneth G., 1023 Groff, Dennis E., 353 Adam, Stephen A., 614 Butel, Janet S., 357 Dreyfuss, Gideon, 614 Grose, Charles, 155, 1195 Ahlers, Suzanne E., 13 Dubois-Dalcq, Monique, 922 Guarino, Linda A., 563 Aldrich, Carol E., 229 Caldwell, Susan E., 678 Dudley, Jaquelin P., 385 Gurney, Elizabeth G., 1168 Alexander, Stephen, 340 Callahan, P. L., 7 Dufraisse, Gabrielle, 81 Almond, Jeffrey W., 1187 Callahan, Robert, 709 Dunn, Glynis, 1187 Haj-Ahmad, Yousef, 267 Aloni, Yosef, 402 Calothy, C., 1191 Hamelin, Richard, 301 Amini, Shohreh, 357 Campbell, Kathryn, 379 Eckhart, Walter, 367 Harada, Shinji, 1159 Amster-Choder, Orna, 402 Candrea, Adina, 81 Edson, Clark M., 1195 Hart, Kevin, 907 Anderson, Janice R., 446 Cardosa, M. Jane, 952 Efstathiou, Stacey, 446 Harvey, Robert W., 50 Arfsten, Ann, 385 Caton, Andrew J., 623 Eiden, Joseph, 706 Haseltine, William A., 379, Arias, Carlos F., 1207 Cerny, Andreas, 1139 Elango, Narayanasamy, 481 738 Ariga, Hiroyoshi, 792 Chamorro, Mario, 992 Elder, John H., 340 Hatanaka, Masakazu, 1159 Arlinghaus, Ralph B., 301 Chanock, Robert M., 721 Ellis, Ronald W., 1195 Haus, Margarete, 335 Arnheiter, Heinz, 922 Charan, Shiv, 1139 Emini, Emilio A., 438, 638 Hay, John, 578 Asselin, Claude, 165 Chen, Tsai-E, 1048 Espejo, Romilio T., 1207 Hay, Nissim, 402 Astell, Caroline R., 656 Chesebro, Bruce, 285, 389 Evans, David M. A., 1187 Hayashi, Kozaburo, 942 Aubert, Christine, 992 Chirikjian, Jack G., 353 Evans, Leonard, 389 Hayman, M. J., 1127 Avendanlo, Luis F., 183 Choi, Yang Do, 614 Evelegh, M. J., 1177 Hayward, Anthony R., 976 Chou, Joany, 629 Helenius, Ari, 603 Chow, Marie, 1094 Falser, Norbert, 335 Hemming, Val G., 721 Bacchetti, S., 1177 Chowdhury, Rukhsana, 960 Fadndez, Gustavo, 183 Hengartner, Hans, 1139 Balachandran, N., 117 Chu, Chi-Ming, 693 Favre, Michel, 688 Henneberry, Jean, 603 Bandtlow, Ingrid, 335 Cizdziel, Paul E., 310 Feldman, Lawrence T., 13 Henry, C., 1191 Bargmann, William J., 371 Clark, H. Fred, 46 Ferre, F., 1191 Herzog, Norbert K., 371 Barkas, Alexander E., 1073 Clark, Karen L., 237 Fichot, Odile, 1181 Hirano, Akiko, 343 Baskar, John F., 1149 Clark, Robin, 539 Field, A. Kirk, 438 Hirsch, Stan, 952 Bastin, Marcel, 165 Clark, Steven, 1182 Field, Hugh J., 446 Hodgman, Charles, 647 Bauer, Eva, 1084 Cole, Charles N., 539 Fleming, Jo-Ann G. W., 552 Hogg, Evelyn, 709 Bauer, William R., 433 Cole, Gerald A., 715 Fluck, Michele M., 205, 211 Holland, John J., 219 Baumann, Raymond P., 816 Colicelli, John, 37, 674 Folk, William R., 237 Horaud, Florian, 81 Bayer, Manfred E., 258 Coligan, John E., 481 Forghani, Bagher, 1195 Horowitz, Mia, 998 Bayer, Margret H., 258 Colonno, Richard J., 7, 246, Frenkel, Niza, 933 Horswood, Robert L., 721 Bechade, C., 1191 438 Friderici, Karen, 205, 211 Horzinek, Marian C., 1010 Beck, Ewald, 983 Constantinou, Andreas, 875 Friedrichs, William E., 155 Hosaka, Yasuhiro, 1113 Begue, A., 1191 Copeland, Terry D., 826 Fukai, Konosuke, 1113 Hruby, Dennis E., 65 Belardelli, Filippo, 456 Cortez, Nenita G., 1048 Fukui, Yasuhisa, 792 Hsiao, W.-L. W., 1119 Bell, Susanne, 647 Costa, Robert H., 1023 Hsu, Chih-Li Lilian, 385 Bennink, Jack R., 786 Cowie, Alison, 505 Gagnon, G. C., 28 Huang, Eng-Shang, 1149 Ben-Porat, Tamar, 191 Crainic, Radu, 81 Gahmberg, Nina, 899 Huegin, Ambros W., 1139 Besemer, Juergen, 1084 Croissant, Odile, 688 Galibert, Francis, 349 Hughes, Pamela J., 1187 Bestwick, Richard K., 534 Crowell, Richard L., 438 Gallahan, Daniel, 709 Hunter-Laszlo, Mary, 976 Beug, H., 1127 Curran, Joseph A., 684 Galloway, Denise A., 802 Hussain, Khalid A., 71 Bhat, Bheem M., 1155 Cuypers, Theo, 1037 Gardiner, Edith M., 656 Hutt-Fletcher, Lindsey M., Bisher, Margaret E., 578 Garreis-Wabnitz, Christine, 117 Bishop, Gail Abendroth, 294 Daillie, Jacques, 1105 968 Bissell, Mina J., 907 Das, Jyotirmoy, 960 Gattoni-Celli, S., 1119 Isfort, Robert J., 464 Blair, Donald G., 301, 310 D'Auriol, Luc, 349 Geballe, Adam P., 864 Ishijima, Yoichi, 670 Blair, Edward D., 1023 Davison, Andrew J., 1195 Gentry, Mary K., 397 Israel, Mark A., 357 Blaisdell, Peter W., 759 Deb, Sumitra, 138 Gerhard, Walter, 623 Issel, Charles J., 71 Blavat, Geraldine, 46, 376 Debuire, B., 1191 Gessani, Sandra, 456 Iwasaki, Yazo, 942 Blissard, Gary W., 318 Deen, Keith C., 422 Gething, Mary-Jane, 603 Blondel, Bruno, 81 de Goede, Ruud, 1037 Ghosh, Prabhat K., 91 Jablonska, Stefania, 688 Bloom, Marshall E., 285 Deiss, Louis P., 933 Ghysdael, Jacques, 1198 Jacobs, Liesbeth, 1010 Bodnar, John W., 1094 DeLucia, Angelo L., 138 Gilden, Donald, 1195 Jambou, Robert C., 481 Boege, Ulrike, 275 DeMarchi, Jean, 191 Gillespie, David A. F., 907 Jashes, Matilde, 183 Bolen, Joseph B., 357 Deppert, Wolfgang, 1168 Girard, Marc, 81 Jenson, A. Bennett, 721 Bose, Henry R., Jr., 371 De Siervo, August J., 809 Glorioso, Joseph C., 294 Jerkofsky, MaryAnn, 809 Brackmann, Karl H., 848 Desrosiers, Ronald C., 701 Goff, Stephen P., 37, 674 Jones, Ronald, 585 Brahic, Michel, 992 de The, Guy, 1105 Gombold, James L., 110 Jones, Stephen N., 1055 Breindl, Michael, 968 de Turenne-Tessier, Mireille, Gonze, Martine, 1198 Brennan, Lynn A., 1073 1105 Gordon, Siamon, 952 Kabat, David, 534 Brodeur, David, 1073 Devi-Rao, Gayathri, 1023 Graeve, Lutz, 968 Kabat, Karen, 301 Bruenn, J. A., 754 Diamond, David, 81, 638 Graham, Frank L., 267 Kai, Chieko, 670 Buchmeier, Michael J., 397 DiMaio, Daniel, 475 Grass, David S., 129 Kalderon, Daniel, 50 Buckler-White, Alicia J., 697 DiPaolo, Joseph A., 572 Green, Kim Y., 893 Kamen, Robert, 505 Buckmaster, Anne, 647 Doms, Robert W., 603 Green, Maurice, 839, 848 Kaplan, Albert S., 191 Buhring, Hans-Jorg, 408 Doniger, Jay, 572 Greenberg, Harry B., 46, 585 Katoh, lyoko, 826 Burkhardt, Anne L., 629 Dorsett, Preston H., 893 Gresser, Ion, 456 Kawashima, Makoto, 688 Bums, Mary C., 1182 Dougherty, Edward M., 197 Grodzicker, Terri, 765 Keck, James G., 729 ii AUTHOR INDEX J. VIROL.

Keller, Paul Malcolm, 1195 Meyers, Michael L., 101 Raines, M. B., 1127 Stanway, Glyn, 1187 Keranen, Sirkka, 899 Minor, Philip D., 1187 Ramig, Robert F., 110 Staprans, Silvija I., 591 Kerr, I. M., 362 Minson, Anthony C., 446, 647 Rando, Robert F., 353 Stark, G. R., 362 Ketner, Gary, 833 Mocarski, Edward S., 864 Rankin, Carolyn, 18 Stavnezer, Edward, 1065, Kettman, Richard, 738 Montelaro, Ronald C., 71 Rao, Veena N., 91 1073 Kikukawa, Ronko, 1159 Moran, Elizabeth, 765 Reddehase, Matthias J., 408 Stec, David S., 715 Ko, Doreen S. W., 275 Moran, Myriam G., 1113 Ren, Gui-Fang, 693 Stehelin, D., 1191 Kobayashi, Nobuyuki, 1159 Moreau-Gachelin, Francoise, Richardson, Christopher, 684 Steinhauer, David A., 219 Kolakofsky, Daniel, 684 349 Richman, Douglas D., 647 Sternglanz, Rolf, 875 Komine, Ken-Ichi, 670 Moreno-L6pez, Jorge, 1173 Risser, Rex, 385 Steven, Alasdair C., 578 Konopka, James B., 1182 Morner, Torsten, 1173 Robbins, Joan M., 709 Stillman, Bruce W., 883 Kooistra, Dale A., 413 Moss, Bernard, 786 Robert-Lezenes, Jacqueline, Stohlman, Stephen A., 729 Koprowski, Hilary, 397 Mosser, Anne G., 246 349 Strebel, Klaus, 983 Koszinowski, Ulrich H., 408 Muirhead, B., 1177 Roberts, Chester R., 578 Stringer, Ruth A., 464 Koyanagi, Yoshio, 1159 Murphy, Brian R., 697, 721 Roberts, Richard J., 765 Strohmaier, Karl, 983 Kozak, Christine, 385, 526, Murphy, Edwin C., Jr., 310 Robinson, H. L., 28 Sullivan, Donna C., 816 709 Rodriguez, L. L., 745 Summers, Max D., 318, 552, Kruppa, Joachim, 968 Naeve, Clayton W., 697 Roizman, Bernard, 629 563 Kuismanen, Esa, 899 Nash, Michael A., 310 Romaine, C. P., 1004 Swain, Margaret A., 802 Kumel, Gunther, 294 Nath, Nrapendra, 101 Rosen, Craig A., 379, 738 Sweet, Raymond W., 422 Kung, Hsing-Jien, 464, 1127 Nemeroff, M. E., 754 Rosenberg, Naomi, 1182 Symington, Janey S., 839, 848 Nishio, Jane, 389 Rosenwirth, Brigitte, 1084 Labieniec-Pintel, Laura, 1163 Nonoyama, Meihan, 145 Rueckert, Roland R., 246 Takada, Kenzo, 1016 Ladin, Beth F., 18 Norrby, Erling, 394 Tambourin, Pierre, 349 Lai, Michael M. C., 729 Notkins, Abner Louis, 397 Saegusa, Junzo, 397 Tamowski, Susan, 1168 La Monica, Nicola, 515 Sakuma, Sadatoshi, 1016 Taniguchi, Hiroyuki, 670 Lancaster, Wayne D., 353 Obalek, Slavomir, 688 Salinovich, Olivia, 71 Tattersall, Peter, 656 Lancz, Gerald, 145 O'Callabhan, Dennis J., 816 Sample, Jeff, 145 Tavitian, Armand, 349 Larsen, Pamela L., 1055 Odenwald, Ward F., 922 Sandino, Ana Maria, 183 Tegtmeyer, Peter, 138 Lazzarini, Robert A., 922 Offit, Paul A., 46, 376 Saule, S., 1191 Templeton, Dennis, 367 Leach, Fredrick S., 864 Ogra, Pearay L., 1203 Sawicki, Dorothea L., 328 Teumer, Jeffrey K., 1065 LeBlanc, Paul A., 117 Ohshima, Kiyoshi, 490, 792 Sawicki, Stanley G., 328 Thompson, Richard L., 1023 Lederman, Howard M., 706 Ohta, Hiroaki, 670 Schaeffer, , 173 Tian, Ying C., 547 Leibson, Paul J., 976 Okada, Hidechika, 670 Schaller, Heinz, 983 Tibbetts, Clark, 1055 Letchworth, G. J., III, 745 Oldstone, Michael B. A., 397 Schiff-Maker, Leslie, 1182 Tjian, Robert, 539 Letvin, Norman L., 701 Ono, Yasushi, 1016 Schild, Geoffrey C., 1187 Tornow, Joanne, 539 Levantis, Pedros, 907 Ooka, Tadamasa, 1105 Schiller, John T., 1 Trepo, Ludmilla Vitvitski, 101 Lewis, Andrew M., Jr., 357 Oroszlan, Stephen, 826 Schlagnhaufer, B., 1004 Trus, Benes L., 578 Li, Jing-Po, 534 Orth, Gerard, 688 Schleif, William A., 438 Tsao, Hsu, 693 Li, Yen, 1065, 1073 Schmaljohn, Alan L., 715 Turck, Claudette Magarian, Lien, Jau-Min, 229 Schmaljohn, Connie S., 715 1065 Long, Le, 1198 Partin, Kathryn, 138 Schnorr, Kenneth L., 71 Long, W. J., 7 Paucha, Eva, 50 Schoenmakers, Harrie, 1037 Long, William L., 438 Payne, Susan L., 71 Schwartz, Stanley A., 294 Vafai, Abbas, 1195 L6pez, Susana, 1207 Pendrys, John, 191 Scraba, Douglas G., 275 van der Zeijst, Bernard A. Lowy, Arthur, 1048 Perrault, Jacques, 917 Seifert, Jan-Marcus, 1084 M., 1010 Lowy, Douglas R., 1 Pettersson, Ralf F., 899 Seriburi, Orrawadee, 1113 Vass, William C., 1 Lucher, Lynne A., 839, 848 Pettersson, Ulf, 848, 1173 Sherry, Barbara, 246 Vass-Marengo, Judit, 165 Luria, Sylvia, 998 Pillemer, Eric A., 413 Sheshberadaran, Hooshmand, Veach, Ruth Ann, 191 Lyles, Douglas S., 678 Pincus, Steven E., 638 394 Velicer, Leland F., 464 Pintel, David, 1163 Shih, Ding S., 547 Venkatesan, Sundararajan, Pinter, Abraham, 1048 Machida, Curtis, 534 Shimizu, Norio, 1016 481 Poddar, Saibal K., 433 Shiroki, Kazuko, 490, 792 Vennstrom, B., 1127 Makino, Shinji, 729 Pollack, Robert, 857 Manley, James L., 129 Silagi, Selma, 1048 Verderame, Michael F., 857 Polvino-Bodnar, Maryellen, Silva, Daniel P., 701 Elcira Mapoles, John E., 438 1094 Villarreal, C., 65 Marrero, Robert, 1145 Silver, Jonathan, 526 Vinson, S. Bradleigh, 318 Porterfield, James S., 952 Simmons, Daniel T., 776 Virtanen, 848 Marshall, R. L., 745 1198 Anders, Martin, P., 1191 Portetelle, Daniel, Simon, Suzanne, 367 Vo, Phuoc T., 585 Mason, William S., 229 Prabhakar, Bellur S., 397 Sitbon, Marc, 389 Voelkel-Meiman, Karen, 875 Mathews, Michael B., 765 Prelich, Gregory, 883 Skehel, J. J., 124 Vonderfecht, Steven, 706 McClintock, J. Thomas, 197 Priehs, Claudette, 205, 211 Smith, Alan E., 50 Vousden, Karen H., 1 Prince, Gregory A., 721 Smith, Geoffrey L., 786 McClure, Marcella A., 917 826 McCorquodale, D. James, 875 Proietti, Enrico, 456 Smythers, Gary W., Wach, M. P., 1004 Pun, Thierry, 578 Sninsky, John J., 101, 173 McCorquodale, Maureen M., Snyder, Robert L., 173 Waddell, Anna, 715 875 Sodroski, Joseph G., 379, 738 Wagner, Edward K., 1023 McGee, Juli S., 340 Quint, Wim, 1037 Spector, Deborah H., 497, 591 Waldron, Linda M., 701 McMahon, M., 362 Spencer, Eugenio, 183 Walsh, Edward E., 721 Medveczky, Peter, 714 Racaniello, Vincent R., 515 Springer, Timothy A., 952 Wang, M.-L., 124 Melief, Cees, 1037 Race, Richard E., 285 Srinivasappa, Javaraiah, 397 Ward, David C., 1094 Mercer, John A., 497 Radaszkiewicz, Thaddaus, Sriskantha, A., 1004 Warner, Huber R., 759 Meriam, Chris, 515 1037 Staczek, John, 816 Weaver, Robert F., 18 Meulemans, Guy, 1198 Rafner, Bjorg, 394 Stanat, Sylvia C., 1149 Wehrly, Kathy, 389 VOL. 57, 1986 AUTHOR INDEX iii

Weinberg, David H., 833 Wildy, Peter, 446 Wroblewska, Zofia, 1195 Yewdell, Jonathan W., 623, Weiner, Ronald M., 197 Wiley, D. C., 124 Wyke, John A., 907 786 Weinstein, I. B., 1119 Wimmer, Eckard, 638 Yolken, Robert, 706 Weissman, Irving L., 413 Winberry, Larry, 211 Yamamoto, Naoki, 1159 Yoshikawa, Yasuhiro, 670 Weissman, Sherman M., 91 Witte, Owen N., 413, 1182 Yamanishi, Koichi, 1195 Yoshinaka, Yoshiyuki, 826 Werner, Fred-Jochen, 1084 Wold, William S. M., 1155 Yamanouchi, Kazuya, 670 Werner, Gudrun, 1084 Wolf, Hans, 335 Yanagi, Kazuo, 942 Zauke, Michael, 968 Westrop, Gareth D., 1187 Wolfinbarger, James, 285 Yasbin, Ronald E., 1145 Zerler, Brad, 765 White, Judy, 603 Wong, David T., 1203 Yasuda, Yuko, 1113 Zijlstra, Maarten, 1037 Wiktor, Tadeusz J., 397 Wong, Timothy C., 343 Yasumoto, Shigeru, 572 Zinkernagel, Rolf M., 1139 SUBJECT INDEX VOLUME 57

Abelson murine leukemia a-Amanitin resistance trans-activating gene mapping, 563 v-abl- and c-abl-encoded molecules vaccinia virus genomic location BamHI M region monoclonal antibodies, 1182 essential vaccinia virus genes, 65 Epstein-Barr virus Acquired immunodeficiency syndrome HindIll N fragment, 65 characterization and mapping, 145 temperature-sensitive mutants, 65 Base substitution levels human leukemic T-cell line Molt 4 Amphotericin B RNA virus single base sites differential susceptibility, 1159 ecotropic murine leukemia virus quantitation, 219 Adenoviruses effect on murine cell fusion, 1048 sequence analysis, 219 ElA gene products Amplicon Bovine herpesvirus 1 lytic and transforming functions, 765 envelope ElA repression DNA cleavage and packaging, 933 biochemical characterization, 745 pseudorabies virus tsG mutant, 13 Antibodies immunological characterization, 745 helper-independent human adenovirus hepatitis B virus Bovine leukemia virus type 5 cloning vector polypeptide X, 101 enhancer sequence activation construction, 267 respiratory syncytial virus infection in long terminal repeats, 738 deletion mutant development, 267 neonates trans-acting regulatory factors, 738 herpes simplex virus type 1 thymidine role of placenta and breast milk, 1203 protease kinase gene transfer, 267 Antigenic variants biological specificity, 826 region E3 mutants type 1 poliovirus gag precursor polyprotein in vitro E3A RNA 3'-end formation, 1155 neutralizing monoclonal antibodies, processing, 826 Adenovirus type 2 81 purification and chemical analysis, DNA-binding Antigenic variation 826 nucleotide mapping, 883 equine infectious anemia virus Bovine papillomavirus structure and function, 883 persistent infection, 71 chimera with minute virus of mice i-leader protein Avian leukosis virus P39 transcription unit of minute virus biosynthesis, 848 lymphomas of mice, 1163 immunoblot analysis, 848 chicken c-myc gene mutations, 28 DNA nonsense mutation immunoprecipitation, 848 proviral insertion and deletion construction, 475 intracellular distribution, 848 patterns, 28 effect on focus formation, 475 late promoter Avian type 1 simian virus 40 transcription and rep- Sloan-Kettering avian retrovirus E5 open reading frame, 1 lication, 129 specific ski sequence identification, transforming sequences, 1 Li-encoded proteins 1065 Bovine papillomavirus 1 biosynthesis and properties, 839 transformation by recombination, transformed hamster embryo cells immunoblot analysis, 839 1073 pp60c-src protein kinase activity, 357 immunoprecipitation, 839 Avian retrovirus MH2 Bovine NCDV transcriptional ER4 v-mil-defective mutants coinfection with simian rotavirus SA-11 host cell shutoff, 833 CL25 provirus cloning and character- neutralization phenotypes, 376 late gene expression, 833 ization, 1191 reassortant RNA segments, 376 viral DNA replication, 833 propagation of subgenomic RNA, virulence compared with simian transformed hamster embryo cells 1191 rotavirus SA-11 pp60c-src protein kinase activity, 357 5-Azacytidine gene segment 4, 46 Adenovirus type 3 endogenous retrovirus-related sequence molecular basis, 46 ElA gene expression expression Bowen's disease of the skin autoregulation, 1055 C3H 1OT1/2 cells, 1119 human papillomavirus Adenovirus type 5 isolation and characterization, 688 ElA gene expression Bacillus subtilis bacteriophage 0105 molecular cloning, 688 autoregulation, 1055 DNA analysis Adenovirus type 12 circular permutation of prophage Campoletis sonorensis virus ElA 13S mRNA unique region genome, 1145 C. sonorensis endoparasitic insertion mutation, 490 Bacteriophages genetic relationship, 552 EiB 58K gene product bacteriophage fd, 258 DNA, 552 cell transformation initiation, 792 bacteriophage T5 parasitized H. virescens larvae viral DNA synthesis, 792 DNA gyrase effect on growth, 875 mRNA infection, mapping, and trans- transformed hamster embryo cells Pre-early gene localization, 759 lation, 318 pp60c-src protein kinase activity, 357 restriction enzyme fragment isolation, protein identification, 318 Adsorptive mutants 759 superhelical DNA homology, 318 influenza A virus B. subtilis bacteriophage +105 Campoletis sonorensis wasps conditions for selection, 623 circular permutation of prophage C. sonorensis virus Agaricus bisporus viruses genome, 1145 genetic relationship, 552 double-stranded RNAs choleraphage i138 infection polydnavirus DNA, 552 synthesis and characterization, 1004 DNA synthesis, 960 proteins Aleutian disease virus replicative intermediates, 960 minute virus of mice monoclonal antibodies E. coli HB11 envelope P39 transcription unit, 1163 antigenic differences among strains, cleavage plane, 258 Capsomers 285 extrusion site, 258 herpes simplex virus type 2 viral antigen sequestration sites, 285 lipid concentration, 258 three-dimensional organization, 578 virus replication sites, 285 Baculoviruses Carbohydrate side chains Alkaline exonuclease gene A. californica nuclear polyhedrosis vi- Rauscher murine leukemia virus enve- herpes simplex virus types 1 and 2 rus lope glycoprotein detailed sequence analysis, 1023 delayed-early gene, 563 neutralizing antibody response, 340 iv VOL. 57, 1986 SUBJECT INDEX v cDNA differential regulation of f and -y genes, DNA sequences adenovirus ElA gene products 864 polyomavirus lytic and transforming functions, 765 early transcript characterization, 591 large T antigen, 505 polioviruses late-gene expression control DNA tumor virus transformation type 1-type 3 recombinant produc- posttranscriptional events, 864 primary hamster embryo cells tion, 1187 , murine pp60c-src protein kinase activity, 357 rotavirus SAl BALB/c and CH3 mice Double-stranded RNA base sequence heterogeneity, 1207 pathogenesis, 497 A. bisporus virus double-stranded RNA, 1207 cloned long-term CTL lines synthesis and characterization, 1004 cDNA library immediate-early membrane antigen Duck hepatitis B virus measles virus-specific gene products specificity, 408 capped oligoribonucleotide expression in primate cells, 343 selection and characterization, 408 minus-strand DNA synthesis tem- Cell surface proteins infection of mouse testes plate, 229 murine leukemia virus replication in sperm cells, 1149 plus-strand DNA synthesis primer, monoclonal antibody, 413 Cytotoxic T lymphocytes 229 orientation in cell membrane, 413 influenza A virus hemagglutinin gene Central nervous system infection product recognition, 786 Early-region promoter Theiler's virus lesions, 992 simian virus 40 Chicken c-myc gene Daudi cells late transcription initiation site, 91 avian leukosis virus-induced mutations, wild-type and interferon-resistant cells recombinant pVNR4, 91 28 c-myc mRNA levels, 362 EcoRI restriction fragments Chickens interferon-induced gene expression, Epstein-Barr virus fowlpox virus infection 362 cloning and mapping, 145 cobra venom factor, 670 Deletion mutant Ecotropic AKV murine leukemia virus complement depletion, 670 simian virus 40 mouse lymphoma DNA Choleraphage 4i138 large T-antigen properties, 539 provirus structures, 1037 infection DNA Encephalomyocarditis virus DNA synthesis, 960 aberrant retroviral clone mouse peritoneal macrophages replicative intermediates, 960 structure and formation, 674 antiviral state of mouse cells, 456 Cobra venom factor bovine papillomavirus Endogenous genome fowlpox virus infection of chickens nonsense mutation, 475 mouse mammary tumor virus complement depletion, 670 cleavage and packaging in herpes gene order, 709 simplex virus mouse chromosome 6, 709 cowpea mosaic virus a sequence amplification, 933 Enhancer sequences viral polypeptide cleavage, 547 use of amplicons, 933 activation in long terminal repeats Complement depletion Epstein-Barr virus fragment bovine leukemia virus, 738 fowlpox virus infection latent genome trans activation, 1016 human T-cell leukemia virus, 738 chickens and embryos, 670 Friend spleen focus-forming virus Core origin of replication endogenous sequences, 349 HeLa and rhabdomyosarcoma cells simian virus 40 herpes simplex virus sequence detection monoclonal antibody, 438 interaction with flanking regulatory restriction enzyme analysis, 446 receptor blockade, 438 sequences, 138 Southern hybridization, 446 Envelope glycoprotein carbohydrate side Coronaviruses human papillomavirus type 16 chains plus- and minus-strand RNA synthesis transformation, 572 Rauscher murine leukemia virus effect of cycloheximide, 328 human papillomavirus type 6 neutralizing antibody response, 340 temporal sequence, 328 cloning and characterization, 353 Envelope glycoproteins Coronaviruses, murine minute virus of mice bovine herpesvirus 1 mixed infection terminal protein, 1094 biochemical characterization, 745 high-frequency RNA recombination, pseudorabies virus immunological characterization, 745 729 detection in inner ear, 335 Envelope, host bacterium Cotton rats DNA binding phage fd infection respiratory syncytial virus simian virus 40 large T antigen cleavage plane, 258 effect of Formalin, 721 binding in mutants, 50 extrusion site, 258 pulmonary pathology, 721 transforming activity, 50 lipid concentration, 258 Cowpea mosaic virus DNA-binding protein E5 open reading frame viral polyprotein cleavage adenovirus type 2 bovine papillomavirus type 1 ATP dependence, 547 nucleotide mapping, 883 transforming sequences, 1 proteolytic activity, 547 structure and function, 883 Epstein-Barr virus DNA-binding region BamHI M region Cycloheximide simian virus 40 tumor antigen characterization and mapping, 145 coronavirus RNA synthesis, 328 location, 776 EcoRI restriction fragments Cyclosporin A DNA gyrase cloning and mapping, 145 humoral immune response to vesicular bacteriophage T5 growth effect of tunicamycin stomatitis virus host A and B subunits, 875 antigen expression, 117 T-dependent antibody response, 1139 inhibition of replication, 875 immunoglobulin synthesis reduction, T-independent antibody response, DNA homology 117 1139 Campoletis sonorensis protein and glycoprotein synthesis, Cytolytic T-lymphocyte lines parasitized H. virescens larvae, 318 117 murine cytomegalovirus equine herpesvirus type 1 and 3 replication inhibition, 117 immediate-early membrane antigen colinear arrangement, 816 specific binding, 117 specificity, 408 Southern blot hybridization, 816 yield reduction, 117 selection and characterization, 408 DNA replication latent genome Cytomegalovirus, human adenovirus type 2 ER4, 833 effect of transfected viral DNA, 1016 vi SUBJECT INDEX J. VIROL.

trans activation, 1016 Friend murine leukemia helper virus identification and localization, 173 thymidine kinase induction strains Guanidine characterization, 1105 early splenomegaly induction resistant poliovirus mutants Equine herpesvirus type 1 and 3 recombinant mink cell focus-forming polypeptide 2C-encoding RNA DNA homology virus generation, 389 sequence, 638 Southern blot hybridization, 816 replication efficiency, 389 resistance mutation, 638 evolutionary relationship, 816 genomic structural analysis, 389 Guanine nucleotide contacts Equine infectious anemia virus Friend murine leukemia virus polyomavirus antigenic and biochemical characteriza- neoplasms in mice large T antigen, 505 tion during infection chromosome 7, 526 Gypsy moth cell line antigenic variation, 71 common proviral integration region, A. californica nuclear polyhedrosis genetic variation, 71 526 virus glycoprotein structure variation, 71 Friend spleen focus-forming virus protein synthesis, 197 Erythroleukemia identification in mouse genome semipermissive replication, 197 Friend spleen focus-forming virus integrated proviral DNA sequence membrane glycoprotein function, 534 analysis, 349 Hamster embryo cells, transformed Erythroleukemic cells octadecanucleotide probe, 349 pp60c-src protein kinase activity Rous-associated virus 1 membrane glycoprotein function, 534 adenovirus 2 and 12, 357 erbB-related protein expression, 1127 mutant and revertant viruses bovine papillomavirus 1, 357 in vitro characterization, 1127 nucleotide sequences, 534 simian virus 40, 357 Escherichia coli Fusion HeLa cells foot-and-mouth disease virus genome influenza virus variant infection inhibition expression hemagglutinin gene, 603 monoclonal antibody, 438 gene product localization and charac- pH dependence, 603 Heliothis virescens larvae terization, 983 Fusion glycoprotein monoclonal antibody Campoletis sonorensis virus hepatitis B virus Newcastle disease virus mRNA identification, mapping, and polypeptide X expression, 101 glycosylation and reactivity, 1198 translation, 318 Escherichia coli HB11 envelope protein identification, 318 phage fd infection Genetic variation superhelical DNA homology, 318 cleavage plane, 258 equine infectious anemia virus Hemagglutination extrusion site, 258 persistent infection, 71 antigen lipid concentration, 258 Genome-linked protein localization by monoclonal anti- European elks bodies, 893 papillomavirus DNA degree of similarity, 1084 Hemagglutinin pulmonary fibromatosis, 1173 molecular cloning, 1084 influenza A virus sequence determination, 1084 adsorptive mutant selection, 623 Fibroblasts Glycoprotein genes influenza virus fusion variant herpes simplex virus type 1 replication varicella-zoster virus genetic structure, 603 inhibition by mononuclear cells, 976 nomenclature, 1195 pH dependence, 603 Fibromas products, 1195 Hemagglutinin antibodies, anti-influenza pulmonary fibromatosis in European Glycoprotein gI postinfection human sera elks pseudorabies virus antigenic drift, 124 papillomavirus DNA, 1173 release from cells, 191 specificity analysis, 124 Fibrotropic minute virus of mice Glycoproteins Hemagglutinin gene correction of earlier DNA sequence, Friend spleen focus-forming virus products in influenza A virus 656 pathogenic function, 534 cross-reactivity, T10 Fischer rat fibroblasts site identification, 534 cytotoxic T lymphocytes, 786 polyomavirus large T antigen herpes simplex virus type 1 Hemagglutinin-neuraminidase glycoprotein serum independence, 211 genetic mapping, 647 human parainfluenza type 3 virus polyomavirus middle and small T isolation and identification, 647 limited amino acid sequence, 481 antigen herpes simplex virus type 1-infected mRNA nucleotide sequence, 481 properties, 211 target cells Newcastle disease virus monoclonal viral proteins, 211 human natural killer cells, 294 antibody Flanking regulatory sequences limiting dilution culture, 294 glycosylation and reactivity, 1198 simian virus 40 Marek's disease herpesvirus Hepatitis B virus interaction with core origin of synthesis, processing, and secretion, polypeptide encoded by ORF X replication, 138 464 expression in E. coli, 101 Glycoprotein, soluble plasmid construction, 101 vesicular stomatitis virus specific antibodies in sera, 101 replication in macrophages formation during or after translation, Herpes simplex virus antibody and complement, 952 968 DNA cleavage and packaging Foot-and-mouth disease virus Glycosylation inhibition a sequence amplification, 933 fusion protein antisera tunicamycin use of amplicons, 933 gene product localization and charac- Epstein-Barr virus production and genome terminal a sequence terization, 983 functions, 117 promoter of gene in L component, Formalin Golgi complex 629 respiratory syncytial virus inactivation Uukuniemi virus glycoproteins latent infection pulmonary pathology in cotton rats, accumulation and morphological DNA sequence detection, 446 721 changes, 899 ribonucleotide reductase subunits Fowlpox virus virus maturation, 899 identification and separation, 1177 infection in chickens and embryos Ground squirrel hepatitis virus reaction with monoclonal antibodies, cobra venom factor, 670 pre-s-encoded polypeptides 1177 complement depletion, 670 hepadnavirus host cell entry, 173 Herpes simplex virus type 1 VOL. 57, 1986 SUBJECT INDEX vii

alkaline exonuclease gene Human papillomavirus type 16 antigenic drift, 124 detailed sequence analysis, 1023 DNA-induced transformation specificity, 124 human natural killer cells NIH 3T3 cells, 572 Insertion mutation glycoprotein specificity, 294 Human parainfluenza type 3 virus Adenovirus type 12 ElA mRNA hydrocephalus in mice hemagglutinin-neuraminidase glyco- polypeptide functions, 490 mechanisms, 942 protein Integrated defective genome morphological alterations, 942 limited amino acid sequence, 481 polyomavirus new glycoprotein mRNA nucleotide sequence, 481 biological properties, 205 genetic mapping, 647 Human pararotavirus origin and structure, 205 isolation and identification, 647 in vitro transcription, 183 superinfection rescue, 205 replication inhibition in fibroblast cul- RNA polymerase Interferon ture activation, 183 Daudi cells, wild type and interferon human blood mononuclear cells, 976 properties, 183 resistant quantitation technique, 976 structure, 183 gene expression, 362 thymidine kinase gene transfer Human peritoneal macrophages human adenovirus type 5 cloning attachment antiviral state of mouse cells, 456 vector, 267 blocking by receptor antibody, 7 Intracisternal A particle Herpes simplex virus type 2 Human 14 long terminal repeat alkaline exonuclease gene mutational analysis transactivation by oncogene products, detailed sequence analysis, 1023 antigen mapping, 246 998 hexavalent capsomers neutralization immunogens three-dimensional organization, 578 antigenic groups, 246 LaFrance disease ribonucleotide reductase subunits monoclonal antibodies, 246 A. bisporus viruses 3'-coterminal transcripts, 802 Human T-cell leukemia virus double-stranded RNA synthesis, 1004 nucleotide sequence analysis, 802 enhancer sequence activation Large T antigen Herpesviruses long terminal repeats, 738 polyomavirus Marek's disease herpesvirus trans-acting regulatory factors, 738 DNA-binding function, 505 A antigen glycoprotein, 464 Human T-cell leukemia virus type II guanine contacts, 505 Herpesvirus saimiri trans activator genes mutant genome, 165 nononcogenic deletion mutants retrovirus vector construction, 379 neoplastic transformation, 165 defective for in vitro immortalization, Human T-cell lymphotrophic virus tumorigenesis, 165 701 type III simian virus 40 Host range restriction human leukemic T-cell line Molt 4 deletion mutants, 539 avian influenza A virus differential susceptibility, 1159 DNA-binding properties, 50 squirrel monkeys, 697 trans activator genes Late gene expression Human adenoviruses retrovirus vector construction, 379 simian virus 40 transformed hamster embryo cells Hydrocephalus transfection into COS and mouse L pp60c-src protein kinase activity, 357 herpes simplex virus type 1 in mice cells, 91 Human adenovirus type 5 cloning vector mechanisms, 942 Latent infection construction, 267 morphological alterations, 942 herpes simplex virus herpes simplex virus type 1 thymidine DNA sequence detection, 446 kinase gene transfer, 267 Immediate-early membrane antigen Lipid metabolism Human cytomegalovirus murine cytomegalovirus varicella-zoster virus strains differential regulation of 1 and y genes, cloned long-term CTL lines, 408 changes in infected cells, 809 864 Immortalization Lymphadenopathy-associated virus early transcripts monkey lymphocytes human leukemic T-cell line Molt 4 cell-related sequences, 591 herpesvirus saimiri, 701 differential susceptibility, 1159 characterization, 591 Immunofluorescence Lymphoid cell lines fine-structure elucidation, 591 monoclonal antibodies reticuloendotheliosis virus late-gene expression control measles virus hemagglutinin, 394 oncogene expression, 371 posttranscriptional events, 864 respiratory syncytial virus Lymphomas Human DNA nucleoprotein, 394 avian leukosis virus murine mammary tumor virus Infectious bovine rhinotracheitis virus chicken c-myc gene mutations, 28 pol-related sequences, 422 envelope proteins proviral insertion and deletion Human herpes simplex virus latent infec- biochemical characterization, 745 patterns, 28 tion immunological characterization, 745 Lymphotropic minute virus of mice DNA sequence detection, 446 Influenza A virus DNA sequence Human lymphoblastoid (Daudi) cells adsorptive mutant selection comparison with fibrotropic strain, wild-type and interferon-resistant cells monoclonal antihemagglutinin anti- 656 c-myc mRNA levels, 362 bodies, 623 Lytic infection interferon-induced gene expression, polyclonal antibody mixture, 623 polyomavirus middle T antigen 362 cloned hemagglutinin gene product rec- large T-antigen genome growth, 367 Human natural killer cells ognition small T-antigen substitution, 367 herpes simplex virus type 1 glycopro- cytotoxic T lymphocytes, 786 tein specificity Influenza A virus, avian Macrophages limiting dilution culture, 294 host range restriction in monkeys, 697 replication Human papillomavirus RNA segment 7 nucleotide sequence, antibody and complement, 952 Bowen's disease of the skin 697 Mahoney type 1 poliovirus isolation and characterization, 688 Influenza viruses neutralizing monoclonal antibody resist- molecular cloning, 688 fusion variant ance mutations Human papillomavirus type 6 DNA hemagglutinin gene, 603 location with respect to antibody- invasive vulvar carcinoma pH dependence, 603 binding site, 81 isolation and characterization, 353 hemagglutinin antibodies molecular basis, 81 viii SUBJECT INDEX J. VIROL.

Marek's disease herpesvirus tumor antigen expression, 857 neutralization immunogens, 246 A antigen glycoprotein T-cell deficiency human rhinoviruses synthesis, processing, and secretion, response to rotavirus infection, 706 blocking of attachment, 7 464 Theiler's virus expression influenza virus Measles virus correlation with white matter lesions, specificity analysis, 124 expression of gene products 992 measles virus and respiratory syncytial cDNA library, 343 West Nile virus virus primate cells, 343 interaction with primary cross-reaction, 394 Measles virus hemagglutinin macrophages, 952 immunofluorescence, 394 comparison with respiratory syncytial Middle T antigen murine leukemia virus virus nucleoprotein polyomavirus cell surface gag protein, 413 cross-reaction, 394 cell transformation, 237 neutralization immunofluorescence, 394 gastrin homology, 237 Sindbis virus variants, 715 radioimmunoprecipitation, 394 phosphorylation, 237 Newcastle disease virus Mengovirus truncated forms hemagglutinin-neuraminidase and fu- 14S capsid precursor particle polyomavirus lytic infection, 367 sion glycoproteins, 1198 purification Middle T-antigen coding region resistance to neutralization immunoaffinity chromatography, 275 polyomavirus location of mutation in type 1 sucrose gradient centrifugation, 275 transformed Fischer rat fibroblasts, poliovirus, 81 Mice 211 rubella virus antigen localization, 893 Abelson murine leukemia virus Mink cell focus-forming virus simian virus 40 large T antigen monoclonal antibodies, 1182 mouse lymphoma DNA binding sites, 1168 BALB/c and C3H strains provirus structures, 1037 Monoclonal antibody LP10 murine cytomegalovirus infection, 497 Mink cell focus-forming virus, re- herpes simplex virus type 1 ecotropic murine leukemia virus combinant new glycoprotein, 647 cell fusion, 1048 generation by Friend murine leukemia Monoclonal antihemagglutinin antibodies Friend murine leukemia virus helper virus strains influenza A virus chromosome 7, 526 early splenomegaly induction, 389 adsorptive mutant selection, 623 common proviral integration region, Minute virus of mice Monoclonal viral antibodies 526 covalently bound protein molecular mimicry neoplasms, 526 identification and characterization, reactivity with normal tissues, 397 Friend spleen focus-forming virus 1094 Mononuclear cells genomic DNA endogenous fibrotropic prototype strain MVM(p) herpes simplex virus type 1 sequences, 349 correction of earlier sequence, 656 replication inhibition, 976 herpes simplex virus latent infection lymphotrophic variant MVM(i) Mouse hepatitis virus DNA sequence detection, 446 comparison with fibrotropic strain, coronavirus plus- and minus-strand herpes simplex virus type 1 hydro- 656 RNA synthesis cephalus DNA sequence, 656 effect of cycloheximide, 328 mechanisms, 942 P39 transcription unit temporal sequence, 328 morphological alterations, 942 both capsid proteins encoded, 1163 mixed infection humoral immune response to vesicular Molecular mimicry high-frequency RNA recombination, stomatitis virus monoclonal viral antibodies 729 effect of cyclosporin A, 1139 reactivity with normal tissues, 397 Mouse L cytoplasts mixed coronavirus infection Moloney murine leukemia virus vaccinia virus infection high-frequency RNA recombination, retrovirus vectors type I topoisomerase activity, 433 729 construction, 379 Mouse mammary tumor provirus mixed rotavirus infection Moloney murine sarcoma virus T-cell lymphoma genome RNA analysis, 110 temperature-sensitive splicing defect molecular cloning and analysis, 385 kinetic analysis, 110 host cell independent, 301 polymorphism, 385 reassortant progeny analysis, 110 virus encoded, 301 synthesis mechanism, 385 mouse mammary tumor virus transformation mutant tsllO Mouse mammary tumor virus endogenous genome, 709 phenotypic reversion in infected cells, endogenous genome mumps virus 310 gene order, 709 cytotoxic T-lymphocyte generation, Monkeys mouse chromosome 6, 709 1113 avian influenza A virus mRNA murine cytomegalovirus host range restriction, 697 Campoletis sonorensis virus from H. infection of testes, 1149 RNA segment 7 nucleotide sequence, virescens larvae replication in sperm cells, 1149 697 identification, 318 murine leukemia virus lymphocyte immortalization in vitro translation, 318 provirus structures in lymphoma herpesvirus saimiri, 701 mapping, 318 DNA, 1037 Monoclonal antibodies protein products, 318 peritoneal macrophages Abelson murine leukemia virus transmissible gastroenteritis virus antiviral state of mouse cells, 456 v-abl- and c-abl-encoded molecules, characterization and translation, 1010 poliovirus type 2 Lansing 1182 vesicular stomatitis virus neurovirulence, 515 Aleutian disease virus interaction with proteins, 614 sequence mapping, 515 antigenic differences among strains, Mumps virus pseudorabies virus DNA 285 infected mice detection in inner ear, 335 viral antigen sequestration sites, 285 cytotoxic T-lymphocyte generation, in situ hybridization, 335 virus replication sites, 285 1113 rotavirus infection HeLa and rhabdomyosarcoma cells Murine cytomegalovirus molecular basis of virulence, 585 enterovirus infection inhibition, 438 BALB/c and C3H mice simian virus 40 receptor blockade, 438 pathogenesis, 497 transfected fibroblasts, 857 human rhinovirus 14 cloned long-term CTL lines VOL. 57, 1986 SUBJECT INDEX ix

immediate-early membrane antigen construction, 475 human papillomavirus type 6 DNA specificity, 408 open reading frame E2, 475 characterization, 353 selection and characterization, 408 Nonstructural proteins cloning, 353 infection of mouse testes Sendai virus isolation, 353 replication in sperm cells, 1149 alternate AUG codons on P/C new virus (HPV34) Murine leukemia virus mRNA, 684 Bowen's disease of the skin, 688 fusion of murine cells ribosomal initiation, 684 isolation and characterization, 688 effect of amphotericin B, 1048 specific peptide sera, 684 molecular cloning, 688 mechanism, 1048 Nuclear polyhedrosis virus Paramyxoviruses glycosylated gag polyproteins A. californica cytotoxic T lymphocytes in mice monoclonal antibody, 413 delayed-early gene, 563 mumps-specific cytotoxicity, 1113 orientation in cell membrane, 413 gypsy moth cell line, 197 Pararotavirus mouse lymphoma DNA infection cycle, 197 in vitro transcription, 183 provirus structures, 1037 protein synthesis, 197 RNA polymerase revertant virus semipermissive replication, 197 activation, 183 isolation, 37 trans-activating gene mapping, 563 properties, 183 primer tRNA, 37 transcriptional activity of 10K protein structure, 183 structure, 37 gene, 18 Phenotypic reversion Murine mammary tumor virus Nuclear protein oncogenes tsllO Moloney murine sarcoma virus pol-related sequences in human DNA intracisternal A particle deletion, 310 characterization, 422 long terminal repeat activity, 998 molecular basis, 310 comparison with complete pol gene, Nucleic acid hybridization thermosensitive splicing, 310 422 pseudorabies virus DNA Phosphorylation Murine rotavirus adaptation of standard techniques, polyomavirus middle T antigen, 237 homologous and heterologous strains 335 Picornaviruses cultivation and characterization, 585 detection in mouse inner ear, 335 human rhinovirus 14 molecular basis of virulence, 585 Nucleocapsid complex neutralization immunogens, 246 Mutation varicella-zoster virus mengovirus 14S capsid precursor resistance to neutralizing monoclonal infected cell nuclear matrix, 155 particles antibodies viral nucleocapsid, 155 purification, 275 location in type 1 poliovirus, 81 Nucleotide sequence analysis proteases and genome-linked protein herpes simplex virus type 2 degree of similarity, 1084 Neonates ribonucleotide reductase subunits, 802 molecular cloning, 1084 respiratory syncytial virus infection sequence determination, 1084 role of breast milk-acquired antibod- Octadecanucleotide probe Plasma membrane ies, 1203 Friend spleen focus-forming virus Sendai virus role of transplacentally acquired anti- provirus identification, 349 interaction with viral proteins, 678 bodies, 1203 mouse genomic DNA endogenous Neoplasms sequences, 349 A. californica nuclear polyhedrosis Friend murine leukemia virus Oligoribonucleotide virus common proviral integration region, duck hepatitis B virus plasmid 39CAT, 563 526 minus-strand DNA synthesis recombinant plasmid pVNR4 mouse chromosome 7, 526 template, 229 simian virus 40 early-region promoter, Neoplastic transformation plus-strand DNA synthesis primer, 91 polyomavirus genome 229 simian virus 40 core sequence-flanking large T antigen, 165 Oncogene expression regulatory sequence interaction Neurovirulence reticuloendotheliosis virus promoter functions, 138 poliovirus type 2 Lansing avian hematopoietic tissues, 371 replication efficiency, 138 mice, 515 transformed lymphoid cell lines, 371 T-antigen binding, 138 Neutralization Oncogene products Plus-strand DNA synthesis rubella virus antigen intracisternal A particle duck hepatitis B virus localization by monoclonal anti- long terminal repeat activity, 998 capped oligonucleotide as primer, 229 bodies, 893 Oncogenes Polioviruses Neutralization epitopes Sloan-Kettering avian retrovirus guanidine-selected mutants Sindbis virus specific ski sequence identification, polypeptide 2C-encoding RNA antibody-selected variation and 1065 sequence, 638 reversion, 715 Sloan-Kettering avian retroviruses resistance mutation, 638 Neutralization immunogens transformation, 1073 type 2 Lansing human rhinovirus 14 Origin DNA binding mouse neurovirulence, 515 monoclonal antibodies, 246 simian virus 40 large T antigen sequence mapping, 515 Neutralizing antibody response binding in mutants, 50 type 1-type 3 recombinants Rauscher murine leukemia virus transforming activity, 50 production by use of cDNA, 1187 deglycosylated virus, 340 Poliovirus, type 1 envelope glycoprotein carbohydrate Papillomaviruses neutralizing monoclonal antibody resist- side chains, 340 bovine papillomavirus ance mutations envelope glycoprotein protein moiety, DNA nonsense mutation, 475 location with respect to antibody- 340 bovine type 1 binding site, 81 Newcastle disease virus E5 open reading frame, 1 molecular basis, 81 hemagglutinin-neuraminidase and fusion transforming sequences, 1 glycoproteins European elks C. sonorensis virus monoclonal antibodies, 1198 pulmonary fibromatosis, 1173 polydnavirus DNA in wasps, 552 Nonsense mutation human papillomavirus type 16 Polymerase error frequencies bovine papillomavirus DNA DNA-induced transformation, 572 RNA virus genome single base sites x SUBJECT INDEX J. VIROL.

quantitation, 219 chicken c-myc gene, 28 role of transplacentally acquired anti- Polyomavirus Provirus, mouse mammary tumor bodies, 1203 integrated defective genome T-cell lymphoma Respiratory syncytial virus nucleoprotein biological properties, 205 molecular cloning and analysis, 385 comparison with measles virus hemag- origin and structure, 205 polymorphism, 385 glutinin superinfection rescue, 205 synthesis mechanism, 385 cross-reaction, 394 large T antigen Pseudorabies virus immunofluorescence, 394 DNA-binding function, 505 Bartha strain radioimmunoprecipitation, 394 guanine contacts, 505 glycoprotein gI, 191 Restriction enzyme fragment isolation neoplastic transformation, 165 release from cells, 191 bacteriophage T5 tumorigenesis, 165 US genome region, 191 pre-early gene localization, 759 middle T antigen virulence, 191 Reticuloendotheliosis virus cell transformation, 237 DNA detection in inner ear transformed lymphoid cell lines and gastrin homology, 237 in situ hybridization, 335 avian tissues phosphorylation, 237 Norden strain oncogene expression, 371 middle T-antigen coding region glycoprotein gI, 191 Retroviruses transformed Fischer rat fibroblasts, release from cells, 191 aberrant clone 211 US genome region, 191 structure and formation, 674 middle T antigen, truncated forms Pseudorabies virus tsG mutant tRNA sequence between LTRs, 674 lytic infection, 367 adenovirus ElA transcription repression endogenous retrovirus-related sequence mutant genome temperature, 13 expression immortalization potential, 165 tsG/adenovirus ratio, 13 C3H 1OT1/2 cells, 1119 Polypeptides wild-type pseudorabies virus, 13 effects of 5-azacytidine, 1119 adenovirus type 12 E1B product Pulmonary fibromatosis HTLV-III cell transformation initiation, 792 fibromas in European elks susceptibility in Molt-4 cells, 1159 viral DNA synthesis, 792 papillomavirus DNA, 1173 reticuloendotheliosis virus woodchuck hepatitis virus pre-s region oncogene expression, 371 identification and localization, 173 Rat cells Retroviruses, recombinant murine Polypeptide X Rous sarcoma provirus expression HTLV-II and HTLV-III/LAV hepatitis B virus gene transcription and regulation, 907 construction, 379 expression in E. coli, 101 role of 5' duplications, 907 Retrovirus MH2 plasmid construction, 101 Rauscher murine leukemia virus v-mil-defective mutants specific antibodies in sera, 101 neutralizing antibody response CL25 provirus cloning and character- Polyprotein cleavage deglycosylated virus, 340 ization, 1191 cowpea mosaic virus envelope glycoprotein carbohydrate propagation of subgenomic RNA, ATP dependence, 547 side chains, 340 1191 proteolytic activity, 547 envelope glycoprotein protein moiety, Reverse transcription pp6Oc-src protein kinase activity 340 duck hepatitis B virus transformed hamster embryo cells Reassortant viruses capped oligoribonucleotide, 229 adenoviruses 2 and 12, 357 mixed rotavirus infection in mice minus-strand DNA synthesis, 229 bovine papillomavirus 1, 357 genome RNA analysis, 110 Revertant virus simian virus 40, 357 kinetic analysis, 110 Moloney murine leukemia virus Pre-early genes progeny analysis, 110 isolation, 37 localization in bacteriophage T5 Receptor antibody primer tRNA, 37 restriction enzyme fragment isolation, human rhinoviruses structure, 37 759 blocking of attachment, 7 Reye's syndrome Primate cells Recombinant murine retroviruses varicella-zoster virus strains measles virus-specific gene product ex- HTLV-II and HTLV-III/LAV neutral lipid metabolism, 809 pression construction, 379 Rhabdomyosarcoma cells cDNA library, 343 Recombinant polioviruses enterovirus infection inhibition Promoter type 1-type 3 intergenic recombinants monoclonal antibody, 438 herpes simplex virus L component gene production by use of cDNA, 1187 Rhesus rotavirus RRV genome terminal a sequence, 629 Recombinant viruses mixed infection with SAl1 in mice Proteases Moloney murine leukemia virus reassortant progeny analysis, 110 bovine leukemia virus isolation, 37 Ribonucleotide reductase subunits biological specificity, 826 primer tRNA, 37 herpes simplex virus gag precursor polyprotein in vitro structure, 37 identification and separation, 1177 processing, 826 Reovirus reaction with monoclonal antibodies, purification and chemical analysis, genome hybridization 1177 826 cellular rRNA, 917 herpes simplex virus type 2 picornaviruses Replicase 3'-coterminal transcripts, 802 degree of similarity, 1084 S. cerevisiae virus, 754 nucleotide sequence analysis, 802 molecular cloning, 1084 Resistance to neutralizing monoclonal an- Ribosomal initiation sequence determination, 1084 tibodies Sendai virus P/C mRNA Proteins location of mutation in type 1 alternate AUG codons, 684 Sendai virus poliovirus, 81 RNA interaction with plasma membrane, Respiratory syncytial virus coronaviruses 678 cotton rats recombination during infection, 729 Proteolytic activity effect of Formalin, 721 simian virus 40 cowpea mosaic virus pulmonary pathology, 721 identification, 402 viral polypeptide cleavage, 547 infection in neonates in vitro synthesis, 402 Proviral insertion and deletion role of breast milk-acquired anti- RNA, double stranded avian leukosis virus bodies, 1203 S. cerevisiae virus VOL. 57, 1986 SUBJECT INDEX xi

conservative replication and trans- Simian rotavirus SAl1 virus encoded, 301 cription, 754 coinfection with bovine rotavirus Stereo images of viral assembly in vitro replication, 754 NCDV vesicular stomatitis virus RNA 3'-end formation neutralization phenotypes, 376 freeze-etch platinum replica method, adenovirus region E3 mutants, 1155 reassortant RNA segments, 376 922 RNA polymerase mixed infection with RRV in mice viral protein immunolabeling, 922 human pararotavirus reassortant progeny analysis, 110 Structural polypeptide activation, 183 virulence compared with bovine vaccinia virus Tian Tan strain properties, 183 rotavirus NCDV late gene cloning and DNA sequence, RNA synthesis gene segment 4, 46 693 coronaviruses molecular basis, 46 Superinfection rescue effect of cycloheximide, 328 Simian virus 40 polyomavirus temporal sequence, 328 adenovirus type 2 late promoter integrated defective genome, 205 RNA viruses early gene expression, 129 genome hybridization replication, 129 T-cell lymphoma cellular rRNA, 917 transcription, 129 mouse mammary tumor provirus RNA virus genome virus viability, 129 molecular cloning and analysis, 385 base substitution levels core origin of replication synthesis mechanism, 385 quantitation, 219 interaction with flanking regulatory Temperature-sensitive defects sequence analysis, 219 sequences, 138 Moloney murine sarcoma virus deletion mutants host cell independent, 301 DNA clones large T-antigen properties, 539 virus encoded, 301 base sequence heterogeneity, 1207 early-region mutants, 857 Terminal protein double-stranded RNA, 1207 early-region promoter minute virus of mice host response recombinant plasmid pVNR4, 91 covalent binding to DNA, 1094 T-cell-deficient mice, 706 large T antigen DNA-binding properties identification and characterization, mixed infections in mice binding in mutants, 50 1094 genome RNA analysis, 110 origin DNA binding, 50 Theiler's virus kinetic analysis, 110 transforming activity, 50 persistence and tissue lesions reassortant progeny analysis, 110 late gene expression central nervous system infection, 992 murine rotavirus primer extension analysis, 91 Thermolabile DNA-binding protein cultivation and characterization, 585 S1 nuclease analysis, 91 adenovirus type 2 neutralization specificity transfection into COS and mouse L nucleotide mapping, 883 gene identification, 376 cells, 91 structure and function, 883 virulence differences among strains monoclonal antibodies for large T Thymidine kinase gene segment 4, 46 antigen induction by Epstein-Barr virus molecular basis, 46 antigenic binding sites, 1168 characterization, 1105 reassortant virus derivation, 46 isolation, 1168 Thymidine kinase gene Rous-associated virus 1 small RNA herpes simplex virus type 1 erythroleukemic cells identification, 402 human adenovirus type 5 cloning erbB-related protein expression, 1127 in vitro synthesis, 402 vector, 267 in vitro characterization, 1127 transformed hamster embryo cells Topoisomerase activity Rous sarcoma virus pp60c-src protein kinase activity, 357 enucleated, synchronized mouse L cells integrated provirus expression in rat tumor antigen cell cycle phase, 433 cells DNA-binding region location, 776 vaccinia virus infection, 433 gene transcription and regulation, 907 purification, 776 virosomes, 433 role of 5' duplications, 907 tumor antigen expression Transcriptase Rubella virus replication-defective , 857 S. cerevisiae virus, 754 antigen localization transfected mouse fibroblasts, 857 Transcription hemagglutination and neutralization, Sindbis virus human cytomegalovirus 893 genome hybridization early transcript characterization, 591 monoclonal antibodies, 893 cellular rRNA, 917 Transmissible gastroenteritis virus neutralization epitopes mRNA characterization, 1010 Sabin type 1 poliovirus antibody-selected variation and mRNA translation, 1010 neutralizing monoclonal antibody resist- reversion, 715 protein identification, 1010 ance mutations Sloan-Kettering avian retroviruses tRNA location with respect to antibody- cloned v-ski oncogene revertant murine leukemia virus binding site, 81 virus transformation by re- primer binding site, 37 molecular basis, 81 combination, 1073 Tumor antigen Saccharomyces cerevisiae virus specific ski sequence simian virus 40 double-stranded RNA identification and properties, 1065 DNA-binding region location, 776 conservative replication and transcrip- Soluble glycoprotein expression in mice, 857 tion, 754 vesicular stomatitis virus purification, 776 in vitro replication, 754 formation during or after translation, Tunicamycin Sendai virus 968 Epstein-Barr virus replication, 117 newly synthesized proteins Splenomegaly, early interaction with plasma membrane, induction by Friend murine leukemia Uukuniemi virus 678 helper virus strains membrane glycoproteins nonstructural protein origin recombinant mink cell focus-forming accumulation in Golgi complex, 899 alternate AUG codons on P/C virus generation, 389 changes of Golgi complex, 899 mRNA, 684 Splicing defect, temperature sensitive ribosomal initiation, 684 Moloney murine sarcoma virus Vaccinia virus specific peptide sera, 684 host cell independent, 301 mouse L cytoplasts xii SUBJECT INDEX J. VIROL.

type I topoisomerase activity, 433 replication in sperm cells, 1149 freeze-etch platinum replica method, temperature-sensitive mutants Vesicular stomatitis virus 922 a-amanitin resistance gene location, base substitution frequency viral protein immunolabeling, 922 65 quantitation methods, 219 Virion assembly of picomaviruses DNA and viral protein synthesis, 65 genome hybridization 14S capsid precursor particle essential vaccinia virus genes, 65 cellular rRNA, 917 purification Tian Tan strain humoral immune response in mice immunoaffinity chromatography, 275 comparison with WR strain, 693 effect of cyclosporin A, 1139 sucrose gradient centrifugation, 275 late gene cloning and DNA sequence, mouse peritoneal macrophages Virosomes 693 antiviral state of mouse cells, 456 vaccinia-associated topoisomerase I, Varicella-zoster virus mRNA-protein interaction in HeLa cells 433 nomenclature conditions, 614 glycoprotein genes, 1195 photochemical cross-linking, 614 West Nile virus glycosylated gene products, 1195 nucleocapsid complex p32-p36 soluble glycoprotein interaction with primary murine macro- infected cell nuclear matrix, 155 formation during or after translation, phages phosphorylation, 155 968 role of cell activation, 952 viral nucleocapsid, 155 stereo images of assembly role of receptors for antibody and strain differentiation freeze-etch platinum replica method, complement, 952 neutral lipid metabolism, 809 922 Woodchuck hepatitis virus Veneral transmission viral protein immunolabeling, 922 pre-s-encoded polypeptides murine cytomegalovirus Viral assembly hepadnavirus host cell entry, 173 mouse testes, 1149 vesicular stomatitis virus stereo images identification and localization, 173 1986 APPLICATION FOR STUDENT MEMBERSHIP IN THE AMERICAN SOCIETY FOR MICROBIOLOGY 1913 I Street, NW * Washington, DC 20006 * (202) 833-9680 COMPLETE ALL INFORMATION REQUESTED AND RETURN FORM WITH REMITTANCE IN U.S. FUNDS Eligibility Any matriculated student majoring in microbiology or a related field is eligible for election as a Student Member. Student Members have all the privileges of membership except the right to vote and hold office in the Society. Student Members receive the monthly ASM News and are entitled to subscribe to the Society's scientific journals at member rates. Initiation Memberships are initiated and renewed in January each year. Unless there are directions to the contrary, membership nominations received prior to November 1 are credited to the currentyear, and back issues of the selected publications for the current year are furnished, if available. Nominations received after November 1 will become effective the following January.

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