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30 September 2002 The Wellcome Trust Annual Review 1 October 2001 –30September2002 1October2001 Review Annual Trust Wellcome The Annual Review 2002 The Wellcome Trust is an independent research-funding charity, established under the will of Sir Henry Wellcome in 1936. It is funded from a private endowment, which is managed with long-term stability and growth in mind. Its mission is to foster and promote research with the aim of improving human and animal health. Its work covers four areas: Knowledge – improving our understanding of human and animal biology in health and disease, and of the past and present role of medicine in society. Resources – providing exceptional researchers with the infrastructural and career support they need to fulfil their potential. Translation – ensuring maximum health benefits are gained from biomedical research. Public engagement – raising awareness of the medical, ethical and social implications of biomedical science. The Wellcome Trust Annual Review 1 October 2001 – 30 September 2002 1 October 2001 Review Annual Trust Wellcome The Annual Review 2002 The Wellcome Trust is an independent research-funding charity, established under the will of Sir Henry Wellcome in 1936. It is funded from a private endowment, which is managed with long-term stability and growth in mind. Its mission is to foster and promote research with the aim of improving human and animal health. Its work covers four areas: Knowledge – improving our understanding of human and animal biology in health and disease, and of the past and present role of medicine in society. Resources – providing exceptional researchers with the infrastructural and career support they need to fulfil their potential. Translation – ensuring maximum health benefits are gained from biomedical research. Public engagement – raising awareness of the medical, ethical and social implications of biomedical science. 1 FROM THE DIRECTOR CONTENTS From the Director Reflecting on 2 Highlights of the year 4 Planning for the future five years at the 6 Financial summary Wellcome Trust 8 Knowledge Advancing knowledge and understanding in the biomedical When I became Director of the With the UK Government, for sciences and their impact on Wellcome Trust in 1998, I wanted example, we have worked on society – past, present and future. to make sure that the Trust retained projects to address the decaying its reputation for leadership, state of research infrastructure 16 Resources independence and distinctiveness. in the UK. In 1998, the Trust Contributing to a long-term and Yet I also wanted to enhance contributed £300 million to the vibrant research environment. two key aspects of its activities: £750 million Joint Infrastructure Such partnerships are not confined These are just a few examples 24 Translation innovation and collaboration. Fund, and in 2000, £225 million to to the UK, and the Trust has a of the Wellcome Trust’s activities the £1.1 billion Science Research long history of working with other over the past five years, a period Advancing the translation of Trust- Having stepped down as Director Investment Fund.These funds are countries.The great strides in that has seen massive – and much funded research into health benefits. in March 2003, it is perhaps an investing in new buildings, tropical medicine being made by needed – investment into UK apt time to reflect on the last five 30 Public engagement laboratories and equipment at our overseas research programmes biomedical research, both by years.We have seen many exciting Engaging with the public through universities throughout the UK. in South-East Asia (Thailand and the Trust and by Government. and remarkable advances during informed dialogue. Vietnam), Kenya and Malawi Such investment by the Trust is this time – the highlight, for me, I must emphasize, however, that would not be possible without the intended to enhance UK research: being the sequencing of the human we see it as the Government’s role enthusiastic support of local it does not, and will not replace 38 A year at the Trust genome. As a nation, we should to support the university research governments and close working investment by the Government. take great pride in the fact that infrastructure. I was particularly relationships with local organizations. In all that it does, the Trust is a UK Funding the UK – through its scientists at pleased with the outcome of the catalyst, not a solution. Career Schemes and Clinical Initiatives the Wellcome Trust Sanger Institute 2002 Spending Review in which Our public engagement programmes International Programmes in Cambridgeshire – should have the Government committed have also been developing rapidly Finally, I would like to say how Centres and Initiatives contributed one-third of the data £500 million per annum for over the last few years. From much I have enjoyed leading the Research Partnerships and Ventures to this huge international university infrastructure from public consultations to innovative Trust through such a productive Medicine, Society and History undertaking. 2004/2005.The Government has approaches that explore science period and give my thanks, not Catalyst BioMedica Ltd put this funding into the baseline, through drama and art, our only to the staff of the Trust, While the independence and indicating that it intends this to approach is very much one of but also to the many individuals scale of the Trust enables it to be a permanent measure. discussion, debate and listening. working within government, the 52 Board of Governors support enterprises such as the One of our latest initiatives is a research and funding councils and development of the Wellcome The Trust is also working closely 53 Advisory committees national network of science other charitable foundations who Trust Genome Campus, much with the Medical Research Council learning centres, a partnership have shared the vision and made of the work we fund requires and Department of Health on between the Trust and the it possible. a collaborative approach – often the UK Biobank project. Using Department for Education and the most fruitful method of genetic information from DNA Dr Mike Dexter Skills.The Trust is allocating up to achieving one’s aims. By working samples and the medical records Director of the Wellcome Trust £25 million over five years to the together with other organizations, of a cohort of 500 000 adults March 2003 initiative that will enable science we can take greater steps towards aged between 45–69, the Biobank teachers to learn more about our common goals – an excellent project will explore the interactions contemporary scientific ideas, example being the Human between genes, environment and train in new teaching approaches, Genome Project involving several lifestyle – and how that impacts and gain experience of new nations, multiple funders and on health – knowledge that will scientific techniques. various institutions. be essential to our understanding of common conditions of later life such as cancer and heart disease. Front cover A malaria parasite oocyst on the outside of a mosquito stomach wall. 1 FROM THE DIRECTOR CONTENTS From the Director Reflecting on 2 Highlights of the year 4 Planning for the future five years at the 6 Financial summary Wellcome Trust 8 Knowledge Advancing knowledge and understanding in the biomedical When I became Director of the With the UK Government, for sciences and their impact on Wellcome Trust in 1998, I wanted example, we have worked on society – past, present and future. to make sure that the Trust retained projects to address the decaying its reputation for leadership, state of research infrastructure 16 Resources independence and distinctiveness. in the UK. In 1998, the Trust Contributing to a long-term and Yet I also wanted to enhance contributed £300 million to the vibrant research environment. two key aspects of its activities: £750 million Joint Infrastructure Such partnerships are not confined These are just a few examples 24 Translation innovation and collaboration. Fund, and in 2000, £225 million to to the UK, and the Trust has a of the Wellcome Trust’s activities the £1.1 billion Science Research long history of working with other over the past five years, a period Advancing the translation of Trust- Having stepped down as Director Investment Fund.These funds are countries.The great strides in that has seen massive – and much funded research into health benefits. in March 2003, it is perhaps an investing in new buildings, tropical medicine being made by needed – investment into UK apt time to reflect on the last five 30 Public engagement laboratories and equipment at our overseas research programmes biomedical research, both by years.We have seen many exciting Engaging with the public through universities throughout the UK. in South-East Asia (Thailand and the Trust and by Government. and remarkable advances during informed dialogue. Vietnam), Kenya and Malawi Such investment by the Trust is this time – the highlight, for me, I must emphasize, however, that would not be possible without the intended to enhance UK research: being the sequencing of the human we see it as the Government’s role enthusiastic support of local it does not, and will not replace 38 A year at the Trust genome. As a nation, we should to support the university research governments and close working investment by the Government. take great pride in the fact that infrastructure. I was particularly relationships with local organizations. In all that it does, the Trust is a UK Funding the UK – through its scientists at pleased with the outcome of the catalyst, not a solution. Career Schemes and Clinical Initiatives the Wellcome Trust Sanger Institute 2002 Spending Review in which Our public engagement programmes International Programmes in Cambridgeshire – should have the Government committed have also been developing rapidly Finally, I would like to say how Centres and Initiatives contributed one-third of the data £500 million per annum for over the last few years.
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