Supplementary Table 3. Genes Predicted to Be Regulated by Myc in KRAS Mutant NSCLC Cells

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Supplementary Table 3. Genes predicted to be regulated by Myc in KRAS mutant NSCLC cells. Normalized basal gene expression microarray data for non-squamous NSCLC NCI60 cell lines were grouped according to KRAS mutation status. Genes showing significant differences in expression between KRAS mutant and KRAS wildtype cells were analyzed using Ingenuity Pathway Analysis (IPA) and genes predicted to be regulated by MYC were identified. Fold Symbol Entrez Gene Name p-value Family Change AMD1 adenosylmethionine decarboxylase 1 0.02 1.50 enzyme BAG1 BCL2-associated athanogene 0.02 2.57 other BRCA1 breast cancer 1, early onset 0.04 1.65 transcription regulator CANX calnexin 0.05 1.78 other CCNA2 cyclin A2 0.02 1.98 other CRIP2 cysteine-rich protein 2 0.04 -4.89 other DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21 0.03 1.59 enzyme EIF4A1 eukaryotic translation initiation factor 4A1 0.04 1.87 translation regulator EMP1 epithelial membrane protein 1 0.03 -6.37 other FABP5 fatty acid binding protein 5 (psoriasis-associated) 0.02 2.26 transporter GAR1 GAR1 ribonucleoprotein homolog (yeast) 0.03 1.56 ion channel GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, 0.01 2.08 enzyme GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) 0.01 2.29 enzyme HIST1H4A histone cluster 1, H4a 0.03 1.97 other HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 0.02 1.89 enzyme HSPA9 heat shock 70kDa protein 9 (mortalin) 0.00 2.01 other HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.03 1.52 enzyme METAP1 methionyl aminopeptidase 1 0.03 1.67 peptidase MYC v-myc myelocytomatosis viral oncogene homolog (avian) transcription regulator NOLC1 nucleolar and coiled-body phosphoprotein 1 0.02 1.94 transcription regulator NOP56 NOP56 ribonucleoprotein 0.01 3.03 other NOP58 NOP58 ribonucleoprotein 0.01 1.61 enzyme PAICS phosphoribosylaminoimidazole carboxylase 0.02 1.72 enzyme PCNA proliferating cell nuclear antigen 0.00 1.96 enzyme PFAS phosphoribosylformylglycinamidine synthase 0.02 2.02 enzyme SHMT1 serine hydroxymethyltransferase 1 (soluble) 0.03 2.10 enzyme SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.01 1.51 transporter TRAP1 TNF receptor-associated protein 1 0.04 1.81 enzyme .

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University of California, San Diego
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Supplemental Data.Pdf
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