Supplementary material -Table of content

Supplementary Figures (Fig 1- Fig 6)

Supplementary Tables (1-13) Lists of genes belonging to distinct biological processes identified by GREAT analyses to be significantly enriched with UBTF1/2-bound genes

Supplementary Table 14 List of the common UBTF1/2 bound genes within +/- 2kb of their TSSs in NIH3T3 and HMECs.

Supplementary Table 15 List of gene identified by microarray expression analysis to be differentially regulated following UBTF1/2 knockdown by siRNA

Supplementary Table 16 List of UBTF1/2 binding regions overlapping with histone genes in NIH3T3 cells

Supplementary Table 17 List of UBTF1/2 binding regions overlapping with histone genes in HMEC

Supplementary Table 18 Sequences of short interfering RNA oligonucleotides

Supplementary Table 19 qPCR primer sequences for qChIP experiments

Supplementary Table 20 qPCR primer sequences for reverse transcription-qPCR

Supplementary Table 21 Sequences of primers used in CHART-PCR

Supplementary Methods

Supplementary Fig 1. (A) ChIP-seq analysis of UBTF1/2 and Pol I (POLR1A) binding across mouse rDNA. UBTF1/2 is enriched at the enhancer and promoter regions and along the entire transcribed portions of rDNA with little if any enrichment in the intergenic spacer (IGS), which separates the rDNA repeats. This enrichment coincides with the distribution of the largest subunit of Pol I (POLR1A) across the rDNA. All sequencing reads were mapped to the published complete sequence of the mouse rDNA repeat (Gene bank accession number: BK000964). The graph represents the frequency of ribosomal sequences enriched in UBTF1/2 and Pol I-ChIPed DNA expressed as fold change over those of input genomic DNA. The lower panel represents a schematic of a single rDNA repeat. Scale bars in kb are shown below; the site of transcription initiation start is indicated at 0kb. En: enhancer elements; ETS: external transcribed spacer; IGS: intergenic spacer.

(B) UBTF1/2 is localized to active NORs. Combined immunofluorescence (IF)-FISH analysis of UBTF1/2 and rDNA in interphasic human fibroblasts. Active NORs are associated with UBTF1/2 while silent NORs (indicated by the arrow) are devoid of

UBTF1/2. Nuclei were visualized by DAPI.

Supplementary Fig 2: UBTF1/2 regulates biological processes linked to chromatin and nucleosome assembly. (A, B) Gene ontology analysis using GREAT of UBTF1/2

ChIP-seq data. The most significantly enriched gene ontologies of UBTF1/2-bound genes for the 3705 peaks in NIH3T3 cells and the 9000 most significant peaks (based on p-value) in HMECs. (C) The most significantly enriched gene ontologies identified by GREAT of the common genes (Fig 1E) which overlap with UBTF1/2

ChIP-seq peaks within +/- 2 kb of their TSSs in the NIH3T3 and HMEC cell lines.

(D) The most significantly enriched ontologies identified using GREAT of UBTF1/2 bound genes that overlapped with Pol II ChIP-seq peaks in NIH3T3 cells. The most significantly enriched ontologies identified using GREAT of the UBTF1/2 bound regions that are common between the HMEC and HMLER ChIP-seq data (E) and the

UBTF1/2 bound regions that are unique to HMLER (F).

Supplementary Fig 3: (A) qChIP analysis of Pol I (POLR1A) binding in NIH3T3 cells to ChIP-seq peaks as indicated. The % of DNA immunoprecipitated with anti-

Pol I or rabbit serum (RS) antibodies was calculated relative to the unprecipitated input control. (n=5) Ave ± s.e.m, *p-value < 0.05 compared to corresponding RS samples. Amplicons at ETS and IGS of rDNA were used as a positive and negative control for Pol I binding, respectively. (B) IGV (Integrated Genome Viewer) screenshots of mapped reads from UBTF1/2 ChIP and input gDNA at HIST1 and

HIST2 clusters in HMEC. (C) A list of the known number of canonical histone genes across the mouse and human genome as described in (Marzluff et al., 2002) and the number of canonical histone genes bound by UBTF1/2 in ChIP-seq data from

NIH3T3 and HMEC. (D) Ubtf1/2 knockdown leads to cell cycle arrest. NIH3T3 cells transfected with sirEgfp, sirUbtf1/2#1 or sirUbtf1/2#2 for 48h were harvested and fixed in 90% ethanol. Cells were stained with propidium iodide at 50 µg/ml in PBS and analysed using the FACSCalibur and Cellquest Pro software (Becton Dickinson).

The percentage of cells in G0/G1, S and G2/M phases were determined using Modfit

3.0 software. (n=3) Ave ± s.e.m, *p< 0.05.

Supplementary Fig 4: UBTF1/2 regulates histone gene expression by mediating Pol

II recruitment. (A) Total protein lysates of NIH3T3 cells transfected with sirEgfp or sirUbtf1/2#1 or sirUbtf1/2#2 for 48h and analysed by western blotting. (B) The results of (n=3) as A were quantitated by phosphoimager scanning, normalized to Tubulin levels and represented graphically, Ave ± s.e.m. **p-value < 0.01, *p-value < 0.05 compared to corresponding sirEgfp controls. (C) ChIP reChIP assay of the histone

H2a, H4 and H1 genes in NIH3T3 cells using UBTF1/2 antibody for the first ChIP and antibodies to Pol I (POLR1A), Pol II or RS for the second ChIP. The % of DNA immunoprecipitated was calculated relative to the first ChIP. Error bars represent Ave

± s.e.m, (n=4), *p-value < 0.05. (D) Ubtf1/2 knockdown does not affect euchromatic and heterochromatic marks or nucleosome occupancy at histone genes. qChIP analysis of the histone H2a and H1 genes in sirEgfp or sirUbtf1/2#1 transfected

NIH3T3 cells using antibodies against UBTF1/2, H3K27me3, H3K9me3, H4 hyperacetylation, H3K4me3, H3K9ac or total histones H3, H4 or H1. qChIPs were performed as described in Fig 4C, (n=3) Ave ± s.e.m, *P < 0.05 compared to sirEgfp

ChIP.

Supplementary Fig 5: The UBTF2 isoform mediates histone gene expression. (A)

Tet-Off inducible RNAi resistant-rUbtf1, rUbtf2 and pRT (empty vector) 3T3-MEF cell lines were stimulated by doxocyclin for 5 days then transfected with sirEgfp or sirUbtf1/2#1 and harvested after 48 h for western blot analysis. (B) qChIP analysis of histone H2a, H1 and H4 genes using antibodies to FLAG in samples as in A (n=3)

Ave ± s.e.m, *p-value < 0.05, **p-value < 0.01 compared to pRT/sirEgfp sample. qChIPs were performed as described in Fig 4C.

Supplementary Fig 6: 48h after transfecting NIH3T3 cells with sirEgfp or sirUbtf1/2#1, IF for UBTF1/2 combined with FISH analysis for rDNA was performed. Nuclei were visualized by DAPI. Ubtf1/2 knockdown cells exhibit micronuclei (yellow arrows).

Supplementary Table 1. List of genes belonging to the biological processes term (Chromatin assembly) identified by GREAT analysis to be significantly enriched with UBTF1/2-bound genes in NIH3T3

Genomic region-gene association table (76 regions, 85 genes)

Gene region (distance to TSS) Asf1a region_320 (+657) Ctcf region_3371 (+651) Gm14483 region_3594 (-223684) Gm5382 region_3598 (+337549) Gm6026 region_3660 (-214579) Gm9998 region_900 (+480) H1f0 region_1282 (+415) H2afb1 region_1861 (-31271) H2afj region_3051 (-4053) H2afx region_3454 (+398) H2afy region_956 (+236) H2afy2 region_1262 (-191749), region_1261 (+232545) H3f3a region_214 (+547) H3f3b region_668 (+512) Hells region_1810 (+60118) Hist1h1a region_909 (-2641), region_910 (-1514) Hist1h1b region_871 (-2615), region_870 (+449) Hist1h1c region_902 (+277) Hist1h1d region_891 (-3550), region_892 (+314) Hist1h1e region_899 (+198) Hist1h2ab region_904 (-4749), region_905 (-4038), region_906 (+261) Hist1h2ac region_900 (-173) Hist1h2ae region_896 (-4868), region_895 (-3053), region_894 (-60) Hist1h2af region_886 (-2602), region_887 (+243) Hist1h2ag region_882 (-26) Hist1h2ah region_880 (-612), region_879 (+284) Hist1h2ai region_864 (+241) Hist1h2ak region_869 (-206) Hist1h2an region_872 (-122) Hist1h2ap region_873 (-71) Hist1h2ap region_876 (-205) Hist1h2bb region_903 (-1476), region_904 (-395), region_905 (+316) Hist1h2bc region_900 (-67) Hist1h2be region_899 (-1236), region_898 (+35400) Hist1h2bf region_896 (-1898), region_895 (-83) Hist1h2bg region_894 (-120) Hist1h2bh region_890 (-1284), region_889 (+187) Hist1h2bj region_881 (-2024), region_882 (-255) Hist1h2bk region_879 (-619), region_880 (+277)

Hist1h2bl region_865 (-1805), region_864 (-520) Hist1h2bm region_865 (-4150), region_866 (-149) Hist1h2bn region_868 (-3788), region_869 (-90) Hist1h2bp region_871 (-4319), region_872 (-148) Hist1h2br region_874 (-1833), region_873 (-97) Hist1h2br region_875 (-1800), region_876 (+37), region_877 (+97428) Hist1h3a region_910 (+232) Hist1h3b region_906 (-1031), region_907 (+252) Hist1h3c region_905 (-1529), region_904 (-818), region_903 (+263) Hist1h3d region_894 (-3191), region_895 (-198), region_896 (+1617) Hist1h3e region_893 (+217) Hist1h3f region_889 (-887), region_890 (+584) Hist1h3g region_886 (-4109), region_887 (-1264), region_888 (+258) Hist1h3h region_864 (-965), region_865 (+320) Hist1h3i region_872 (-3943), region_871 (+228) Hist1h4a region_910 (-997), region_909 (+130) Hist1h4b region_907 (-4389), region_908 (+222) Hist1h4c region_901 (+215) Hist1h4d region_897 (+241), region_898 (+4122) Hist1h4f region_892 (-3703), region_891 (+161) Hist1h4h region_885 (-30980), region_886 (+265) Hist1h4i region_882 (-1623), region_881 (+146) Hist1h4j region_867 (+199) Hist1h4k region_869 (-3528), region_868 (+170) Hist1h4n region_873 (-1450), region_874 (+286) Hist1h4n region_876 (-1622), region_875 (+215) Hist2h2aa2 region_2262 (+883) Hist2h2ab region_2261 (+508) Hist2h2ac region_2261 (+420) Hist2h2bb region_2266 (-325) Hist2h2be region_2261 (-697) Hist2h3b region_2266 (+681) Hist2h3c1 region_2262 (-283) Hist2h3c1 region_2263 (+330), region_2264 (+1661) Hist2h4 region_2265 (+213), region_2264 (+16118) Hist4h4 region_3051 (+184) Hmga2 region_429 (-86238), region_428 (+882) Myst3 region_3253 (+266) Nap1l1 region_409 (+366) Nap1l3 region_3635 (-322987) Rbbp4 region_2550 (+408) Set region_1889 (+4971) Shprh region_269 (+36392) Smarca2 region_1789 (-619185) Smarca5 region_3331 (+536) Sox9 region_660 (+504)

Supplementary Table 2. List of genes belonging to the biological processes term (Chromatin assembly and disassembly) identified by GREAT analysis to be significantly enriched with UBTF1/2-bound genes in HMEC

Genomic region-gene association table (156 regions, 111 genes)

Gene region (distance to TSS) ARID1A region_5198 (-75222), region_4816 (-420), region_4562 (+48515), region_3302 (+76649) ARID2 region_6633 (-474411), region_2512 (-319625), region_2781 (-314136), region_3668 (-2660), region_1999 (-2154), region_454 (-855), region_2383 (+140), region_3044 (+848) ASF1A region_250 (+795) BAZ1B region_4233 (+437) CASC5 region_7628 (+269) CDKN2A region_6286 (+163535) CENPK region_1625 (-423) CENPN region_900 (-73728), region_7466 (+233) CHAF1A region_7444 (+884), region_4638 (+10760) CHAF1B region_1378 (+44690) CTCF region_2200 (+953) H1F0 region_2581 (-52527), region_3700 (-32848), region_3797 (+409) H1FX region_2580 (+607), region_2024 (+38280) H2AFJ region_7899 (-3799), region_450 (+354) H2AFX region_222 (+325) H2AFY region_2752 (+61905), region_7439 (+160390), region_3608 (+263569) H2AFY2 region_1840 (+338) H3F3B region_7612 (+1224) H3F3B region_2485 (-28006), region_7403 (+903) H3F3C region_7317 (-167679), region_4800 (+99932) HILS1 region_4344 (-27432), region_6142 (-5640) HIST1H1A region_5778 (-3984) HIST1H1B region_3024 (-4430) HIST1H1C region_5839 (+584) HIST1H1T region_6508 (-5375) HIST1H2AB region_730 (+197) HIST1H2AC region_374 (-143) HIST1H2AD region_296 (-182) HIST1H2AE region_162 (-146) HIST1H2AG region_5303 (-470), region_179 (+208) HIST1H2AH region_188 (-476), region_613 (+212), region_4114 (+91561) HIST1H2AJ region_2263 (-563), region_89 (+160) HIST1H2AK region_460 (-560), region_5337 (+1188) HIST1H2AL region_2375 (+168)

HIST1H2AM region_1228 (-570), region_6149 (+205) HIST1H2BB region_1145 (-1952) HIST1H2BC region_374 (-98), region_6508 (+10393) HIST1H2BD region_353 (+245), region_1458 (+815) HIST1H2BE region_1658 (+180) HIST1H2BF region_2086 (-3880), region_2586 (-2601), region_296 (-134) HIST1H2BG region_162 (-130) HIST1H2BH region_3890 (+194) HIST1H2BI region_7410 (-1801), region_5563 (+222), region_6555 (+6587) HIST1H2BJ region_179 (-450), region_5303 (+228), region_1215 (+112646), region_6334 (+175727), region_361 (+301601), region_2615 (+339513), region_4099 (+360974) HIST1H2BK region_613 (-483), region_188 (+205) HIST1H2BL region_1355 (-2391), region_523 (-464), region_2507 (+145), region_6935 (+744), region_1855 (+119982) HIST1H2BM region_1355 (-4722), region_89 (-464), region_2263 (+259) HIST1H2BN region_5337 (-1511), region_460 (+237) HIST1H2BO region_6149 (-445), region_1228 (+330) HIST1H3B region_730 (-1311), region_1706 (+183) HIST1H3C region_1145 (+198) HIST1H3D region_296 (-189), region_2586 (+2278), region_2086 (+3557) HIST1H3F region_3890 (-1238) HIST1H3G region_5563 (-1814), region_7410 (+209) HIST1H3H region_6935 (-1012), region_2507 (-413), region_523 (+196) HIST1H3I region_3024 (+310) HIST1H3J region_1228 (-2963), region_6149 (-2188) HIST1H4A region_5778 (+117) HIST1H4B region_1706 (-4625) HIST1H4C region_7464 (+246) HIST1H4E region_2354 (+187) HIST1H4G region_3890 (-4868) HIST1H4H region_334 (+284), region_6555 (+5936) HIST1H4J region_356 (+258) HIST1H4K region_373 (+191) HIST2H2AA3 region_200 (-156), region_3752 (+894) HIST2H2AA3 region_543 (-97) HIST2H2AB region_408 (+910) HIST2H2AC region_408 (+31) HIST2H2BC region_2489 (-2170), region_543 (-191) HIST2H2BE region_408 (-324) HIST2H2BF region_1930 (-994) HIST2H3C region_543 (-1650), region_2489 (+329) HIST2H3C region_200 (-1709), region_3752 (-659), region_5761 (+666) HIST2H3D region_1930 (+314) HIST2H4A region_715 (-62) HIST2H4A region_696 (+187)

HIST3H2A region_2607 (+270) HIST3H2BB region_2607 (-518), region_5509 (+6341) HIST4H4 region_450 (-3559), region_7899 (+594) HMGA1 region_1754 (-91513) HMGA2 region_7279 (-226847), region_4482 (-165077), region_671 (+45), region_3673 (+1540) HMGB2 region_2328 (-448), region_7525 (+163941) HP1BP3 region_3566 (+280), region_4308 (+54071) ITGB3BP region_151 (-89), region_4406 (+81905) KAT6A region_593 (-88048) KAT6B region_4836 (-573306), region_7445 (-535282), region_7171 (-508333), region_4591 (-477431), region_4795 (-340456), region_3014 (-186848), region_4213 (+203084) MIS18BP1 region_506 (+264) MTA2 region_2527 (+42) NAP1L1 region_7149 (-193483) NAP1L4 region_5647 (+53619) NAP1L5 region_2855 (-8905) NPM1 region_5211 (+3301), region_7147 (+12804) OIP5 region_5831 (-494), region_1643 (+48296) RBBP4 region_5235 (-747), region_7622 (+374) SET region_4673 (+1384) SHPRH region_2346 (+267) SMARCA5 region_3675 (+785) SMARCC1 region_749 (-370), region_7710 (+171737) SMARCC2 region_6030 (-16998), region_4971 (+29502) SMARCD1 region_7239 (-14801) SMARCD3 region_6032 (-65061), region_516 (-51044) SMARCE1 region_645 (-393) SOX9 region_6647 (-137051), region_164 (+608), region_824 (+1813), region_3655 (+183193), region_1116 (+344475), region_5789 (+446358), region_5860 (+470988) SUPT16H region_50 (+446) TNP1 region_1381 (-652890), region_1910 (-209143) TSPY2 region_1917 (+288871) TSPYL1 region_4477 (+593) TSPYL2 region_3988 (-29525), region_3100 (-10531) TSPYL5 region_4640 (+214900) TSPYL6 region_2824 (+48262)

Supplementary Table 3. List of genes belonging to the biological processes term (Regulation of gene silencing) identified by GREAT analysis to be significantly enriched with UBTF1/2-bound genes from the intersected gene list of UBTF1/2 bound genes within +/- 2 kb of their TSSs in NIH3T3 and HMECs

Genomic region-gene association tables (14 regions, 8 genes)

Gene ChIP-seq region (distance TSS) Hist1h3b unnamed (-1030), unnamed (+253) Hist1h3c unnamed (-818), unnamed (+263) Hist1h3d unnamed (-3191), unnamed (-197), unnamed (+1617) Hist1h3f unnamed (-887), unnamed (+584) Hist1h3g unnamed (-4109), unnamed (+259) Hist1h3h unnamed (+321) Hist1h3i unnamed (+227) Sirt1 unnamed (+470)

Supplementary Table 4. List of genes belonging to the biological processes term (Chromatin assembly) identified by GREAT analysis to be significantly enriched with UBTF1/2-bound genes from the intersected gene list of UBTF1/2 bound genes within +/- 2 kb of their TSSs in NIH3T3 and HMECs

Genomic region-gene association tables (33 regions, 47 genes)

Gene ChIP-seq region (distance to TSS) Gm9998 unnamed (+479) H1f0 unnamed (+416) H2afj unnamed (-4052) H2afx unnamed (+398) H2afy2 unnamed (+232544) H3f3b unnamed (+511) Hist1h1a unnamed (-2641) Hist1h1b unnamed (-2616) Hist1h1c unnamed (+277) Hist1h1e unnamed (+198) Hist1h2ab unnamed (-4749), unnamed (+262) Hist1h2ac unnamed (-174) Hist1h2ae unnamed (-4868), unnamed (-3054), unnamed (-60) Hist1h2af unnamed (-2602) Hist1h2ag unnamed (-27) Hist1h2ah unnamed (-612), unnamed (+283) Hist1h2ak unnamed (-207) Hist1h2bb unnamed (-1476), unnamed (-395) Hist1h2bc unnamed (-66)

Hist1h2be unnamed (-1236) Hist1h2bf unnamed (-1898), unnamed (-84) Hist1h2bg unnamed (-120) Hist1h2bh unnamed (-1284), unnamed (+187) Hist1h2bj unnamed (-254) Hist1h2bk unnamed (-618), unnamed (+277) Hist1h2bl unnamed (-1806) Hist1h2bm unnamed (-4149), unnamed (-149) Hist1h2bn unnamed (-3787), unnamed (-89) Hist1h2bp unnamed (-4318) Hist1h3b unnamed (-1030), unnamed (+253) Hist1h3c unnamed (-818), unnamed (+263) Hist1h3d unnamed (-3191), unnamed (-197), unnamed (+1617) Hist1h3f unnamed (-887), unnamed (+584) Hist1h3g unnamed (-4109), unnamed (+259) Hist1h3h unnamed (+321) Hist1h3i unnamed (+227) Hist1h4a unnamed (+130) Hist1h4b unnamed (-4388) Hist1h4h unnamed (+265) Hist1h4i unnamed (-1624) Hist1h4j unnamed (+200) Hist1h4k unnamed (-3529), unnamed (+169) Hist4h4 unnamed (+183) Hmga2 unnamed (+881) Myst3 unnamed (+266) Rbbp4 unnamed (+407) Sox9 unnamed (+504)

Supplementary Table 5. List of genes belonging to the biological processes term (Nucleosome assembly) identified by GREAT analysis to be significantly enriched with UBTF1/2-bound genes from the intersected gene list of UBTF1/2 bound genes within +/- 2 kb of their TSSs in NIH3T3 and HMECs

Genomic region-gene association tables (31 regions, 45 genes)

Gene ChIP-seq region (distance to TSS)

Gm9998 unnamed (+479) H1f0 unnamed (+416) H2afj unnamed (-4052) H2afx unnamed (+398) H2afy2 unnamed (+232544) H3f3b unnamed (+511) Hist1h1a unnamed (-2641) Hist1h1b unnamed (-2616) Hist1h1c unnamed (+277) Hist1h1e unnamed (+198) Hist1h2ab unnamed (-4749), unnamed (+262) Hist1h2ac unnamed (-174) Hist1h2ae unnamed (-4868), unnamed (-3054), unnamed (-60) Hist1h2af unnamed (-2602) Hist1h2ag unnamed (-27) Hist1h2ah unnamed (-612), unnamed (+283) Hist1h2ak unnamed (-207) Hist1h2bb unnamed (-1476), unnamed (-395) Hist1h2bc unnamed (-66) Hist1h2be unnamed (-1236) Hist1h2bf unnamed (-1898), unnamed (-84) Hist1h2bg unnamed (-120) Hist1h2bh unnamed (-1284), unnamed (+187) Hist1h2bj unnamed (-254) Hist1h2bk unnamed (-618), unnamed (+277) Hist1h2bl unnamed (-1806) Hist1h2bm unnamed (-4149), unnamed (-149) Hist1h2bn unnamed (-3787), unnamed (-89) Hist1h2bp unnamed (-4318) Hist1h3b unnamed (-1030), unnamed (+253) Hist1h3c unnamed (-818), unnamed (+263) Hist1h3d unnamed (-3191), unnamed (-197), unnamed (+1617) Hist1h3f unnamed (-887), unnamed (+584) Hist1h3g unnamed (-4109), unnamed (+259)

Hist1h3h unnamed (+321) Hist1h3i unnamed (+227) Hist1h4a unnamed (+130) Hist1h4b unnamed (-4388) Hist1h4h unnamed (+265) Hist1h4i unnamed (-1624) Hist1h4j unnamed (+200) Hist1h4k unnamed (-3529), unnamed (+169) Hist4h4 unnamed (+183) Myst3 unnamed (+266) Sox9 unnamed (+504)

Supplementary Table 6. List of genes belonging to the biological processes term (negative regulation of megakaryocytic differentiation) identified by GREAT analysis to be significantly enriched with UBTF1/2-bound genes from the intersected gene list of UBTF1/2 and Pol II peaks in NIH3T3

Genomic region-gene association tables (18 regions, 12 genes)

Gene ChIP-seq region (distance to TSS) Hist1h4a region_1859 (-997), region_1858 (+130) Hist1h4b region_1856 (-4388), region_1857 (+222) Hist1h4c region_1851 (+214) Hist1h4d region_1848 (+242) Hist1h4f region_1843 (-3703), region_1842 (+161) Hist1h4h region_1836 (-30980), region_1837 (+265) Hist1h4i region_1834 (-1624), region_1833 (+145) Hist1h4j region_1822 (+200) Hist1h4k region_1824 (-3529), region_1823 (+169) Hist1h4n region_1828 (+287) Hist2h4 region_731 (+212) Hist4h4 region_1192 (+183)

Supplementary Table 7. List of genes belonging to the biological processes term (Chromatin assembly) identified by GREAT analysis to be significantly enriched with UBTF1/2-bound genes from the intersected gene list of UBTF1/2 and Pol II peaks in NIH3T3

Genomic region-gene association tables (58 regions, 73 genes)

Gene ChIP-seq region (distance to TSS) Asf1a region_1281 (+657) Ctcf region_1370 (+652) Gm9998 region_1850 (+479) H1f0 region_135 (+416) H2afb1 region_480 (-31271) H2afj region_1192 (-4052) H2afx region_1419 (+398) H2afy region_1890 (+235) H2afy2 region_124 (+232544) H3f3a region_667 (+547) H3f3b region_1716 (+511) Hist1h1a region_1858 (-2641), region_1859 (-1514) Hist1h1b region_1826 (-2616), region_1825 (+448) Hist1h1c region_1852 (+277) Hist1h1d region_1842 (-3550), region_1843 (+314) Hist1h1e region_1849 (+198) Hist1h2ab region_1854 (-4749), region_1855 (+262) Hist1h2ac region_1850 (-174) Hist1h2ae region_1847 (-4868), region_1846 (-3054), region_1845 (-60) Hist1h2af region_1837 (-2602), region_1838 (+243) Hist1h2ag region_1834 (-27) Hist1h2ah region_1832 (-612), region_1831 (+283) Hist1h2ai region_1819 (+241) Hist1h2ak region_1824 (-207) Hist1h2an region_1827 (-122) Hist1h2bb region_1853 (-1476), region_1854 (-395) Hist1h2bc region_1850 (-66) Hist1h2be region_1849 (-1236) Hist1h2bf region_1847 (-1898), region_1846 (-84) Hist1h2bg region_1845 (-120) Hist1h2bh region_1841 (+187) Hist1h2bj region_1833 (-2023), region_1834 (-254) Hist1h2bk region_1831 (-618), region_1832 (+277) Hist1h2bl region_1820 (-1806), region_1819 (-520) Hist1h2bm region_1820 (-4149), region_1821 (-149) Hist1h2bn region_1823 (-3787), region_1824 (-89) Hist1h2bp region_1826 (-4318), region_1827 (-148) Hist1h2br region_1828 (-1834)

Hist1h3a region_1859 (+232) Hist1h3b region_1855 (-1030), region_1856 (+253) Hist1h3c region_1854 (-818), region_1853 (+263) Hist1h3d region_1845 (-3191), region_1846 (-197), region_1847 (+1617) Hist1h3e region_1844 (+216) Hist1h3f region_1841 (-887) Hist1h3g region_1837 (-4109), region_1838 (-1264), region_1839 (+259) Hist1h3h region_1819 (-965), region_1820 (+321) Hist1h3i region_1827 (-3943), region_1826 (+227) Hist1h4a region_1859 (-997), region_1858 (+130) Hist1h4b region_1856 (-4388), region_1857 (+222) Hist1h4c region_1851 (+214) Hist1h4d region_1848 (+242) Hist1h4f region_1843 (-3703), region_1842 (+161) Hist1h4h region_1836 (-30980), region_1837 (+265) Hist1h4i region_1834 (-1624), region_1833 (+145) Hist1h4j region_1822 (+200) Hist1h4k region_1824 (-3529), region_1823 (+169) Hist1h4n region_1828 (+287) Hist2h2aa2 region_730 (+883) Hist2h2ab region_729 (+508) Hist2h2ac region_729 (+420) Hist2h2bb region_732 (-325) Hist2h2be region_729 (-697) Hist2h3b region_732 (+681) Hist2h3c1 region_730 (-283) Hist2h4 region_731 (+212) Hist4h4 region_1192 (+183) Hmga2 region_1546 (+881) Myst3 region_1303 (+266) Nap1l1 region_1539 (+366) Rbbp4 region_890 (+407) Set region_497 (+4971) Smarca5 region_1346 (+536) Sox9 region_1710 (+504)

Supplementary Table 8. List of genes belonging to the biological processes term (Regulation of gene silencing) identified by GREAT analysis to be significantly enriched with UBTF1/2-bound genes from the intersected gene list of UBTF1/2 and Pol II peaks in NIH3T3

Genomic region-gene association tables (20 regions, 12 genes)

Gene ChIP-seq region (distance to TSS) Hist1h3a region_1859 (+232) Hist1h3b region_1855 (-1030), region_1856 (+253) Hist1h3c region_1854 (-818), region_1853 (+263) Hist1h3d region_1845 (-3191), region_1846 (-197), region_1847 (+1617) Hist1h3e region_1844 (+216) Hist1h3f region_1841 (-887) Hist1h3g region_1837 (-4109), region_1838 (-1264), region_1839 (+259) Hist1h3h region_1819 (-965), region_1820 (+321) Hist1h3i region_1827 (-3943), region_1826 (+227) Hist2h3b region_732 (+681) Hist2h3c1 region_730 (-283) Sirt1 region_1378 (+470)

Supplementary Table 9. List of genes belonging to the biological processes term (Chromatin assembly or disassembly) identified by GREAT analysis to be significantly enriched with UBTF1/2-bound genes from the intersected gene list of UBTF1/2 and Pol II peaks in NIH3T3

Genomic region-gene association tables (55 regions, 70 genes)

Gene ChIP-seq region (distance to TSS) Asf1a region_1281 (+657) Gm9998 region_1850 (+479) H1f0 region_135 (+416) H2afb1 region_480 (-31271) H2afj region_1192 (-4052) H2afx region_1419 (+398) H2afy region_1890 (+235) H2afy2 region_124 (+232544) H3f3a region_667 (+547) H3f3b region_1716 (+511) Hist1h1a region_1858 (-2641), region_1859 (-1514) Hist1h1b region_1826 (-2616), region_1825 (+448) Hist1h1c region_1852 (+277) Hist1h1d region_1842 (-3550), region_1843 (+314) Hist1h1e region_1849 (+198) Hist1h2ab region_1854 (-4749), region_1855 (+262) Hist1h2ac region_1850 (-174) Hist1h2ae region_1847 (-4868), region_1846 (-3054), region_1845 (-60) Hist1h2af region_1837 (-2602), region_1838 (+243) Hist1h2ag region_1834 (-27) Hist1h2ah region_1832 (-612), region_1831 (+283) Hist1h2ai region_1819 (+241) Hist1h2ak region_1824 (-207) Hist1h2an region_1827 (-122) Hist1h2bb region_1853 (-1476), region_1854 (-395) Hist1h2bc region_1850 (-66) Hist1h2be region_1849 (-1236) Hist1h2bf region_1847 (-1898), region_1846 (-84) Hist1h2bg region_1845 (-120) Hist1h2bh region_1841 (+187) Hist1h2bj region_1833 (-2023), region_1834 (-254) Hist1h2bk region_1831 (-618), region_1832 (+277) Hist1h2bl region_1820 (-1806), region_1819 (-520) Hist1h2bm region_1820 (-4149), region_1821 (-149) Hist1h2bn region_1823 (-3787), region_1824 (-89) Hist1h2bp region_1826 (-4318), region_1827 (-148) Hist1h2br region_1828 (-1834)

Hist1h3a region_1859 (+232) Hist1h3b region_1855 (-1030), region_1856 (+253) Hist1h3c region_1854 (-818), region_1853 (+263) Hist1h3d region_1845 (-3191), region_1846 (-197), region_1847 (+1617) Hist1h3e region_1844 (+216) Hist1h3f region_1841 (-887) Hist1h3g region_1837 (-4109), region_1838 (-1264), region_1839 (+259) Hist1h3h region_1819 (-965), region_1820 (+321) Hist1h3i region_1827 (-3943), region_1826 (+227) Hist1h4a region_1859 (-997), region_1858 (+130) Hist1h4b region_1856 (-4388), region_1857 (+222) Hist1h4c region_1851 (+214) Hist1h4d region_1848 (+242) Hist1h4f region_1843 (-3703), region_1842 (+161) Hist1h4h region_1836 (-30980), region_1837 (+265) Hist1h4i region_1834 (-1624), region_1833 (+145) Hist1h4j region_1822 (+200) Hist1h4k region_1824 (-3529), region_1823 (+169) Hist1h4n region_1828 (+287) Hist2h2aa2 region_730 (+883) Hist2h2ab region_729 (+508) Hist2h2ac region_729 (+420) Hist2h2bb region_732 (-325) Hist2h2be region_729 (-697) Hist2h3b region_732 (+681) Hist2h3c1 region_730 (-283) Hist2h4 region_731 (+212) Hist4h4 region_1192 (+183) Myst3 region_1303 (+266) Nap1l1 region_1539 (+366) Set region_497 (+4971) Smarca5 region_1346 (+536) Sox9 region_1710 (+504)

Supplementary Table 10. List of genes belonging to the biological processes term (Nucleosome assembly) identified by GREAT analysis to be significantly enriched with UBTF1/2-bound genes from the intersected gene list of UBTF1/2 bound regions in HMEC and HMLERs

Genomic region-gene association tables (64 regions, 64 genes)

Gene ChIP-seq region (distance to TSS) CASC5 MACS_peak_10402 (+325) CENPK MACS_peak_24272 (-215) CENPN MACS_peak_12387 (+595) H1F0 MACS_peak_20780 (-52574), MACS_peak_20783 (+188) H1FX MACS_peak_22346 (+37261) H2AFJ MACS_peak_7309 (-4142), MACS_peak_7310 (+442) H2AFY2 MACS_peak_4245 (+750) H3F3B MACS_peak_14464 (+439) H3F3C MACS_peak_7444 (-167314) HILS1 MACS_peak_13993 (-5679) HIST1H1B MACS_peak_26049 (+1159), MACS_peak_26049 (+1159) HIST1H1C MACS_peak_25940 (+719) HIST1H1E MACS_peak_25946 (+446) HIST1H2AC MACS_peak_25944 (+443) HIST1H2AD MACS_peak_25953 (-252) HIST1H2AE MACS_peak_25957 (+323) HIST1H2AG MACS_peak_25997 (-139), MACS_peak_25997 (-139) HIST1H2AH MACS_peak_25998 (-149), MACS_peak_25998 (-149) HIST1H2AJ MACS_peak_26044 (-137), MACS_peak_26044 (-137) HIST1H2AK MACS_peak_26048 (-549) HIST1H2AL MACS_peak_26049 (+1093), MACS_peak_26049 (+1093) HIST1H2AM MACS_peak_26052 (-312), MACS_peak_26052 (-312) HIST1H2BB MACS_peak_25939 (-1840) HIST1H2BC MACS_peak_25944 (-684) HIST1H2BD MACS_peak_25946 (-1344), MACS_peak_25947 (+557), MACS_peak_25947 (+557) HIST1H2BE MACS_peak_25949 (+145) HIST1H2BF MACS_peak_25952 (-2590), MACS_peak_25953 (-64) HIST1H2BG MACS_peak_25957 (-599) HIST1H2BI MACS_peak_25964 (-67) HIST1H2BJ MACS_peak_25997 (-103), MACS_peak_25997 (-103), MACS_peak_25993 (+112682), MACS_peak_25992 (+176003) HIST1H2BK MACS_peak_25998 (-122), MACS_peak_25998 (-122) HIST1H2BL MACS_peak_26043 (-2344), MACS_peak_26042 (-71), MACS_peak_26042 (-71), MACS_peak_26042 (-71), MACS_peak_26035 (+119970) HIST1H2BM MACS_peak_26043 (-4769), MACS_peak_26044 (-167), MACS_peak_26044 (-167)

HIST1H2BN MACS_peak_26048 (+226) HIST1H2BO MACS_peak_26052 (+72), MACS_peak_26052 (+72) HIST1H3B MACS_peak_25935 (+94) HIST1H3C MACS_peak_25939 (+86) HIST1H3D MACS_peak_25953 (-259), MACS_peak_25952 (+2267) HIST1H3G MACS_peak_25964 (-1525) HIST1H3H MACS_peak_26042 (-197), MACS_peak_26042 (-197), MACS_peak_26042 (-197) HIST1H3J MACS_peak_26052 (-2705), MACS_peak_26052 (-2705) HIST1H4B MACS_peak_25935 (-4714) HIST1H4C MACS_peak_25942 (+283) HIST1H4E MACS_peak_25954 (+103) HIST1H4H MACS_peak_25970 (-36865) HIST2H2AB MACS_peak_2184 (+683) HIST2H2AC MACS_peak_2184 (+258) HIST2H2BE MACS_peak_2184 (-551) HIST2H2BF MACS_peak_2181 (-448), MACS_peak_2181 (-448) HIST2H3D MACS_peak_2181 (+860), MACS_peak_2181 (+860) HIST3H2A MACS_peak_3448 (-478) HIST3H2BB MACS_peak_3448 (+230) HIST4H4 MACS_peak_7310 (-3647), MACS_peak_7309 (+937) HMGB2 MACS_peak_23786 (-188) HP1BP3 MACS_peak_621 (+172), MACS_peak_620 (+54285) ITGB3BP MACS_peak_1616 (-174) KAT6A MACS_peak_29409 (-88550) MIS18BP1 MACS_peak_9394 (+138), MACS_peak_9394 (+138) OIP5 MACS_peak_10428 (-345), MACS_peak_10427 (+48222) RBBP4 MACS_peak_1037 (-352), MACS_peak_1037 (-352) SHPRH MACS_peak_27128 (+20) SMARCA5 MACS_peak_23672 (+628) SOX9 MACS_peak_14368 (+470817) TSPYL1 MACS_peak_26945 (+833)

Supplementary Table 11. List of genes belonging to the biological processes term (Regulation of G1/S transition of mitotic cell cycle) identified by GREAT analysis to be significantly enriched with UBTF1/2-bound genes from the unique gene list of UBTF1/2 bound regions in HMLER cells

Biological Process: regulation of G1/S transition of mitotic cell cycle

Gene ChIP-seq region (distance to TSS) ATM MACS_peak_6687 (-135) BID MACS_peak_20435 (+947) CCND1 MACS_peak_6337 (-607996), MACS_peak_6341 (-531245), MACS_peak_6352 (-143832), MACS_peak_6356 (-2251) CDK2 MACS_peak_7794 (+108) CDKN1A MACS_peak_26397 (+76213), MACS_peak_26400 (+151294) DGKZ MACS_peak_5819 (-66011), MACS_peak_5822 (-14722) DLG1 MACS_peak_22982 (-211422), MACS_peak_22977 (-158240), MACS_peak_22975 (-96436), MACS_peak_22972 (+168) FBXO31 MACS_peak_12529 (+66314), MACS_peak_12522 (+454380), MACS_peak_12518 (+599829), MACS_peak_12517 (+702600) FHL1 MACS_peak_32164 (+455) GML MACS_peak_30140 (-18653) GTSE1 MACS_peak_21058 (+157) HRAS MACS_peak_5292 (+16972) HUS1 MACS_peak_27924 (+100) INO80 MACS_peak_10422 (-337) MDM2 MACS_peak_7962 (+69) NBN MACS_peak_29682 (+332) PCBP4 MACS_peak_21770 (-332), MACS_peak_21769 (+11027) PML MACS_peak_10897 (+336) PPP2R5C MACS_peak_10109 (-133926), MACS_peak_10112 (-361), MACS_peak_10116 (+186638) PRMT2 MACS_peak_20421 (+85) PSMA4 MACS_peak_11025 (+232) PSMA5 MACS_peak_1941 (+160) PSMA6 MACS_peak_9351 (-22), MACS_peak_9351 (-22), MACS_peak_9354 (+44537), MACS_peak_9354 (+44537), MACS_peak_9355 (+49699), MACS_peak_9355 (+49699) PSMB1 MACS_peak_27344 (+115117) PSMB10 MACS_peak_12201 (+769) PSMB2 MACS_peak_1110 (+82) PSMB4 MACS_peak_2252 (+139), MACS_peak_2253 (+58527) PSMB7 MACS_peak_31116 (+72207), MACS_peak_31108 (+156502) PSMB8 MACS_peak_26258 (-371) PSMC1 MACS_peak_9942 (+139), MACS_peak_9942 (+139) PSMC2 MACS_peak_28435 (+320)

PSMC3 MACS_peak_5859 (+6) PSMC4 MACS_peak_16526 (-235) PSMC5 MACS_peak_14229 (-138) PSMC6 MACS_peak_9469 (+168), MACS_peak_9469 (+168) PSMD1 MACS_peak_18779 (-3907) PSMD10 MACS_peak_32044 (+100) PSMD11 MACS_peak_13365 (+167) PSMD12 MACS_peak_14294 (+216), MACS_peak_14289 (+86165) PSMD13 MACS_peak_5272 (-307) PSMD14 MACS_peak_18358 (-70013), MACS_peak_18359 (-63304) PSMD2 MACS_peak_22774 (+153) PSMD4 MACS_peak_2247 (-54) PSMD5 MACS_peak_31046 (-100) PSMD6 MACS_peak_21923 (-191080) PSMD7 MACS_peak_12321 (+217) PSMD8 MACS_peak_16458 (-12545) PSME1 MACS_peak_9289 (+227), MACS_peak_9289 (+227) PSME2 MACS_peak_9291 (-658), MACS_peak_9291 (-658) PSME3 MACS_peak_13670 (+43) PSMF1 MACS_peak_18982 (+162) PTPN6 MACS_peak_7214 (-19184), MACS_peak_7215 (-8876), MACS_peak_7217 (-59) RB1 MACS_peak_8884 (+237) RBM38 MACS_peak_19919 (-2083), MACS_peak_19921 (+4363), MACS_peak_19922 (+44453) RFWD3 MACS_peak_12329 (+150) RPS27L MACS_peak_10662 (+22) TP53 MACS_peak_12930 (+443) TP73 MACS_peak_164 (-71), MACS_peak_168 (+50628), MACS_peak_170 (+64380), MACS_peak_171(+94629) UBA52 MACS_peak_16206 (-116) UBB MACS_peak_13039 (+110), MACS_peak_13041 (+5875) USP17L2 MACS_peak_29045 (-55837), MACS_peak_29044 (+22750) WNT9A MACS_peak_3423 (+514) ZC3H12D MACS_peak_27154 (+34035)

Supplementary Table 12. List of genes belonging to the biological processes term (Mitotic cell cycleG1/S transition DNA damage checkpoint) identified by GREAT analysis to be significantly enriched with UBTF1/2-bound genes from the unique gene list of UBTF1/2 bound regions in HMLER cells

Biological Process: Mitotic cell cycleG1/S transition DNA damage checkpoint

Gene ChIP-seq region (distance to TSS) ATM MACS_peak_6687 (-135) BID MACS_peak_20435 (+947) CCND1 MACS_peak_6337 (-607996), MACS_peak_6341 (-531245), MACS_peak_6352 (-143832), MACS_peak_6356 (-2251) CDK2 MACS_peak_7794 (+108) CDKN1A MACS_peak_26397 (+76213), MACS_peak_26400 (+151294) DGKZ MACS_peak_5819 (-66011), MACS_peak_5822 (-14722) DLG1 MACS_peak_22982 (-211422), MACS_peak_22977 (-158240), MACS_peak_22975 (-96436), MACS_peak_22972 (+168) FBXO31 MACS_peak_12529 (+66314), MACS_peak_12522 (+454380), MACS_peak_12518 (+599829), MACS_peak_12517 (+702600) FHL1 MACS_peak_32164 (+455) GML MACS_peak_30140 (-18653) GTSE1 MACS_peak_21058 (+157) HRAS MACS_peak_5292 (+16972) HUS1 MACS_peak_27924 (+100) INO80 MACS_peak_10422 (-337) MDM2 MACS_peak_7962 (+69) NBN MACS_peak_29682 (+332) PCBP4 MACS_peak_21770 (-332), MACS_peak_21769 (+11027) PML MACS_peak_10897 (+336) PPP2R5C MACS_peak_10109 (-133926), MACS_peak_10112 (-361), MACS_peak_10116 (+186638) PRMT2 MACS_peak_20421 (+85) PSMA4 MACS_peak_11025 (+232) PSMA5 MACS_peak_1941 (+160) PSMA6 MACS_peak_9351 (-22), MACS_peak_9351 (-22), MACS_peak_9354 (+44537), MACS_peak_9354 (+44537), MACS_peak_9355 (+49699), MACS_peak_9355 (+49699) PSMB1 MACS_peak_27344 (+115117) PSMB10 MACS_peak_12201 (+769) PSMB2 MACS_peak_1110 (+82) PSMB4 MACS_peak_2252 (+139), MACS_peak_2253 (+58527) PSMB7 MACS_peak_31116 (+72207), MACS_peak_31108 (+156502) PSMB8 MACS_peak_26258 (-371) PSMC1 MACS_peak_9942 (+139), MACS_peak_9942 (+139) PSMC2 MACS_peak_28435 (+320)

PSMC3 MACS_peak_5859 (+6) PSMC4 MACS_peak_16526 (-235) PSMC5 MACS_peak_14229 (-138) PSMC6 MACS_peak_9469 (+168), MACS_peak_9469 (+168) PSMD1 MACS_peak_18779 (-3907) PSMD10 MACS_peak_32044 (+100) PSMD11 MACS_peak_13365 (+167) PSMD12 MACS_peak_14294 (+216), MACS_peak_14289 (+86165) PSMD13 MACS_peak_5272 (-307) PSMD14 MACS_peak_18358 (-70013), MACS_peak_18359 (-63304) PSMD2 MACS_peak_22774 (+153) PSMD4 MACS_peak_2247 (-54) PSMD5 MACS_peak_31046 (-100) PSMD6 MACS_peak_21923 (-191080) PSMD7 MACS_peak_12321 (+217) PSMD8 MACS_peak_16458 (-12545) PSME1 MACS_peak_9289 (+227), MACS_peak_9289 (+227) PSME2 MACS_peak_9291 (-658), MACS_peak_9291 (-658) PSME3 MACS_peak_13670 (+43) PSMF1 MACS_peak_18982 (+162) PTPN6 MACS_peak_7214 (-19184), MACS_peak_7215 (-8876), MACS_peak_7217 (-59) RB1 MACS_peak_8884 (+237) RBM38 MACS_peak_19919 (-2083), MACS_peak_19921 (+4363), MACS_peak_19922 (+44453) RFWD3 MACS_peak_12329 (+150) RPS27L MACS_peak_10662 (+22) TP53 MACS_peak_12930 (+443) TP73 MACS_peak_164 (-71), MACS_peak_168 (+50628), MACS_peak_170 (+64380), MACS_peak_171 (+94629) UBA52 MACS_peak_16206 (-116) UBB MACS_peak_13039 (+110), MACS_peak_13041 (+5875) USP17L2 MACS_peak_29045 (-55837), MACS_peak_29044 (+22750) WNT9A MACS_peak_3423 (+514) ZC3H12D MACS_peak_27154 (+34035)

Supplementary Table 13. List of genes belonging to the biological processes term (DNA damage response, signal transduction by p53) identified by GREAT analysis to be significantly enriched with UBTF1/2-bound genes from the unique gene list of UBTF1/2 bound regions in HMLER cells

Gene ChIP-seq region (distance to TSS) ATM MACS_peak_6687 (-135) CDK2 MACS_peak_7794 (+108) CDKN1A MACS_peak_26397 (+76213), MACS_peak_26400 (+151294) GML MACS_peak_30140 (-18653) GTSE1 MACS_peak_21058 (+157) MDM2 MACS_peak_7962 (+69) PCBP4 MACS_peak_21770 (-332), MACS_peak_21769 (+11027) PML MACS_peak_10897 (+336) PPP2R5C MACS_peak_10109 (-133926), MACS_peak_10112 (-361), MACS_peak_10116 (+186638) PSMA4 MACS_peak_11025 (+232) PSMA5 MACS_peak_1941 (+160) PSMA6 MACS_peak_9351 (-22), MACS_peak_9351 (-22), MACS_peak_9354 (+44537), MACS_peak_9354 (+44537), MACS_peak_9355 (+49699), MACS_peak_9355 (+49699) PSMB1 MACS_peak_27344 (+115117) PSMB10 MACS_peak_12201 (+769) PSMB2 MACS_peak_1110 (+82) PSMB4 MACS_peak_2252 (+139), MACS_peak_2253 (+58527) PSMB7 MACS_peak_31116 (+72207), MACS_peak_31108 (+156502) PSMB8 MACS_peak_26258 (-371) PSMC1 MACS_peak_9942 (+139), MACS_peak_9942 (+139) PSMC2 MACS_peak_28435 (+320) PSMC3 MACS_peak_5859 (+6) PSMC4 MACS_peak_16526 (-235) PSMC5 MACS_peak_14229 (-138) PSMC6 MACS_peak_9469 (+168), MACS_peak_9469 (+168) PSMD1 MACS_peak_18779 (-3907) PSMD10 MACS_peak_32044 (+100) PSMD11 MACS_peak_13365 (+167) PSMD12 MACS_peak_14294 (+216), MACS_peak_14289 (+86165) PSMD13 MACS_peak_5272 (-307) PSMD14 MACS_peak_18358 (-70013), MACS_peak_18359 (-63304) PSMD2 MACS_peak_22774 (+153) PSMD4 MACS_peak_2247 (-54) PSMD5 MACS_peak_31046 (-100) PSMD6 MACS_peak_21923 (-191080) PSMD7 MACS_peak_12321 (+217) PSMD8 MACS_peak_16458 (-12545)

PSME1 MACS_peak_9289 (+227), MACS_peak_9289 (+227) PSME2 MACS_peak_9291 (-658), MACS_peak_9291 (-658) PSME3 MACS_peak_13670 (+43) PSMF1 MACS_peak_18982 (+162) RBM38 MACS_peak_19919 (-2083), MACS_peak_19921 (+4363), MACS_peak_19922 (+44453) TP53 MACS_peak_12930 (+443) UBA52 MACS_peak_16206 (-116) UBB MACS_peak_13039 (+110), MACS_peak_13041 (+5875)

Supplementary Table 14. List of the common UBTF1/2-bound genes within +/- 2kb of their TSSs in NIH3T3 and HMEC cell lines

Gene Symbol ABCD3 ABHD12 ABR ABTB2 ACO1 ACSL3 ACTG1 ADAM10 ADAMTS1 ADSS AEBP1 AGBL5 AGPAT3 AGPS AHI1 AKAP9 AMOTL2 ANKRD13C ANKRD52 ANP32E ANTXR1 APBB2 APC API5 ARFGEF1 ARHGAP5 ARID1A ARIH1 ARL4C ARL6IP2 ARL8A ATAD2 ATAD2B ATG2A ATP11B ATP1B3 ATP2A2 ATXN1 ATXN2 B4GALT6 BACH2 BAG3 BAHCC1 BAZ2B BBX BCAR3 BDNF BIRC6 BMI1 BMPER BMPR1A BNC2 BPTF BRD1 BRD2 BRWD2 BTAF1 BTBD1 BTG1 BZW1 CAB39 CACHD1 CAMK2D CAND1 CAPN2 CAPN7

CAPRIN1 CBFA2T2 CBFB CCDC100 CCDC109A CCDC131 CCDC142 CCDC44 CCDC85B CCDC88A CCDC96 CCNC CCND3 CCNYL1 CCRN4L CD44 CD47 CDC25A CDC27 CDC2L5 CDC42EP1 CDC42SE2 CDK6 CDKN1B CDKN2AIP CDKN2C CDV3 CEBPB CEBPD CENTB2 CENTG3 CHST11 CHSY1 CITED2 CLIP1 CLOCK CLSTN1 CLTC CMTM6 CNIH CNN3 CNNM3 CNOT2 CNOT4 COBLL1 COG3 COL4A1 COL4A3BP COPZ1 CPE CPEB2 CREB1 CRIM1 CRTC3 CSF1 CUL1 CUL3 CUL4A DAAM1 DCBLD1 DDAH1 DDHD2 DDIT4 DDR1 DDX42 DEGS1 DICER1 DIDO1 DIP2C DLG5 DLST

DLX2 DNAJB14 DNAJC1 DNM1L DOCK8 DSE DTWD1 DUSP1 DUSP10 DUSP12 DUSP16 DUSP4 DUSP6 DUSP7 DYNLL2 DYRK1A E2F5 EDEM1 EEF1A1 EEF2K EFNA5 EFNB2 EGLN1 EIF2C2 EIF3J EIF4G2 EIF5B ELAC1 ELF2 ELL2 EML1 ENDOD1 EP300 EPHA2 ERBB2IP ERMP1 ERN1 ERRFI1 ETNK1 ETS1 ETS2 EXOSC4 EXOSC6 EXOSC7 EXOSC8 EXT1 EXTL3 FAM102B FBXL11 FBXO45 FBXW4 FEM1B FGD6 FGFBP3 FGFR1 FIGN FIP1L1 FKBP5 FMNL2 FNBP4 FNDC3B FOSL2 FOXC1 FOXC2 FOXJ2 FOXK1 FOXK2 FOXP1 FRMD6 FRYL FSCN1

FYN FZD3 FZD7 GAB1 GADD45A GALNT2 GARNL1 GAS1 GCLM GDNF GFOD1 GGNBP2 GHR GLG1 GLUD1 GNAQ GPD2 GPR125 GRAMD3 GRSF1 H1F0 H2AFX H3F3B HDGF HDGFRP3 HECTD1 HEG1 HERPUD2 HIAT1 HIF1A HINT1 HIPK1 HIPK3 HIST1H1C HIST1H1E HIST1H2AB HIST1H2AE HIST1H2AG HIST1H2AH HIST1H2BB HIST1H2BC HIST1H2BF HIST1H2BH HIST1H2BK HIST1H2BM HIST1H2BN HIST1H3B HIST1H3C HIST1H3D HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H4A HIST1H4H HIST1H4J HIST1H4K HIST4H4 HIVEP2 HLX HMGA2 HMGB1 HNRNPU HNRPLL HOXA2 HOXA3 HOXA5 HPS6 HS2ST1 HSPA8 IARS2

ICT1 ID1 IER5 IER5L IGF1R IGHMBP2 INTS8 IRF2 IRX1 IRX2 IRX5 ITGA6 ITGAV ITGB1BP1 ITGB5 ITSN2 JAG1 JAK2 JMJD1B JUN KCMF1 KLF10 KLF4 KLF5 KLF6 KLHDC2 KLHL11 KLHL21 KLHL22 KTN1 LAMC1 LASP1 LASS5 LASS6 LATS1 LATS2 LEMD2 LEMD3 LGR4 LIN9 LNPEP LOX LPHN2 LRIG1 LRIG3 LRP11 LRRC1 LRRC41 LRRC58 LRRC8C LRRK2 LTBP3 LTBR LUZP1 MAGI1 MAN2A1 MAP3K4 MAP4K5 MAPK14 MAPK6 MAPK8IP3 MARK3 MARS2 MARVELD1 MAZ MBNL1 MBTPS2 MCL1 MED13 MED26 MEIS1

MEIS2 MEX3C MGAT1 MGAT4B MIB1 MICALL1 MIER1 MINPP1 MKLN1 MLF2 MLLT4 MPPE1 MSH6 MTDH MTFR1 MYC MYH9 MYO10 MYO18A MYO1B MYO5A MYO6 MYST3 NAT12 NCOA7 NCOR1 NDEL1 NDFIP1 NDST2 NDUFS7 NEDD4 NEDD4L NEK9 NFATC3 NFE2L2 NFKB1 NIPBL NOTCH2 NPEPPS NR2F1 NR2F2 NRD1 NRF1 NRG1 NRIP1 NRP1 NRP2 NSFL1C NUDT3 NUDT4 NUP54 NXN OBSL1 OPN3 ORAI1 OSBPL11 OSBPL1A OSBPL3 OSMR OTUD7B OXA1L OXR1 P4HA1 PAIP1 PAK2 PANK1 PANK2 PAWR PBX3 PCBD2 PCBP1

PCBP2 PCGF2 PCGF6 PCNX PCTK2 PCYT1A PDCD6IP PDGFA PDGFC PDK1 PDZD8 PELI1 PHC3 PHF17 PHLDA1 PHLDA3 PHLPP PIK3R1 PITPNC1 PJA2 PKD2 PKP4 PLK2 PLXNA2 POLG POLR3E POM121 PPAP2B PPIL3 PPM1B PPM1L PPP1R12A PPP1R15B PPP1R9B PPP2R5A PPP3R1 PRCC PRKAR2A PRKCE PRMT6 PROS1 PRPSAP1 PRRX1 PSMD14 PSMD3 PSPH PTEN PTGFRN PTMA PTP4A1 PTP4A2 PTPLA PTPN9 PTPRG PTRF PURB PVRL1 RAB11FIP5 RAB28 RAB33B RAC1 RAF1 RANBP2 RANBP9 RAP1GDS1 RAP2B RAPH1 RASAL2 RASSF3 RB1CC1 RBBP4

RBM12B RBMS1 RDH10 RDX REEP3 REL RELL1 REST REV3L RGL2 RGMB RGS20 RHOB RHOBTB3 RIPK5 RND3 RNF11 RNF14 RNF146 RNF149 RNF19A RNPEP ROD1 ROR1 RPL23 RREB1 RRM2B RSBN1 RTN4 RUFY1 RUNX1 RUNX2 RXRA SAMD1 SAMD14 SAP30 SAP30L SCARB2 SCHIP1 SCLT1 SCYL1 SEC24B SEC31A SEC63 SENP6 SERBP1 SETD5 SETD7 SFPQ SFRS1 SFRS2 SGPP1 SH3RF1 SHB SHFM1 SHOC2 SIAH2 SIRT1 SIX1 SKI SLAIN2 SLC12A2 SLC16A1 SLC22A15 SLC25A3 SLC25A30 SLC25A37 SLC30A4 SLC35A1 SLC44A1 SLC4A7

SLCO3A1 SLK SLMAP SMAD7 SMARCE1 SMC4 SMC5 SMO SMURF2 SNRPB SNTB2 SNX5 SOCS3 SOLH SOX4 SOX9 SP3 SPATA5L1 SPRED1 SPRY2 SRF SRXN1 SS18 STEAP1 STEAP2 STIM2 STK17B STK39 SUV420H1 TAF5 TANC1 TBC1D12 TBC1D20 TBCC TBX18 TBX3 TCF7L2 TDRD3 TEAD3 TESK2 TFDP2 TGFBR2 TGFBR3 THAP4 TIA1 TJP2 TKT TLE1 TLK2 TM9SF3 TMCC3 TMED2 TMEM165 TMEM168 TMEM16F TMEM17 TMEM183A TMEM55A TMF1 TOB1 TOP2B TRAM2 TRIB1 TRIB2 TRIM27 TRIM33 TRIM47 TRIM8 TRIO TRIP12 TRPM7

TSC22D1 TSG101 TSHZ1 TSPAN5 TTC32 TTRAP TWIST1 TWSG1 TXNDC5 UBAP2L UBB UBE2A UBE2D2 UBE2D3 UBE2J1 UBE2R2 UBL3 UBN1 UBR2 UBTD1 UBTF UIMC1 UPF1 USP24 USP3 USP47 USPL1 UTRN VCP VDAC1 VEGFA VPS36 VPS4A VRK2 WASL WBP4 WDFY3 WDR22 WDR32 WEE1 WHSC1L1 WNK1 WNT5A WRNIP1 WWTR1 XPOT YAF2 ZBTB1 ZBTB7A ZC3H6 ZC3H7B ZCCHC14 ZCCHC2 ZDHHC1 ZDHHC17 ZFAND5 ZFP36L2 ZFYVE16 ZMIZ1 ZMYND11 ZMYND19 ZNHIT2 ZNRF2 ZXDC ZZZ3

Supplementary Table 15. List of genes identified by microarray expression analysis to be differentially regulated following Ubtf1/2 knockdown

Fold change (FC) raw P values GeneSymbol FC.sirUbtf1/2#1 vs Mock FC.sirUbtf1/2#2 vs Mock FC.sirUbtf1/2#1 vs sirEgfp FC.sirUbtf1/2#2 vs sirEgfp raw P value sirUbtf1/2#1 vs Mock raw P value sirUbtf1/2#2 vs Mock raw P value sirUbtf1/2#1 vs sirEgfp raw P value sirUbtf1/2#2 vs sirEgfp Slc4a4 -3.316579495 -2.185056663 -3.367770606 -2.218782819 4.47E-09 8.48E-07 3.80E-09 6.76E-07 Fancb -2.474811256 -1.582269802 -2.695727896 -1.723512787 1.12E-06 0.000982132 3.88E-07 0.000227143 --- -2.181226341 -1.948015673 -2.620081681 -2.339949818 0.000972477 0.003163874 0.000154986 0.000474825 Snora73a -2.073970184 -1.913116171 -2.442023325 -2.252623662 0.000506703 0.001320354 7.98E-05 0.000195673 Idi1 -2.692902457 -2.027969355 -2.435357173 -1.834017307 1.20E-06 4.63E-05 4.03E-06 0.000202048 Cenpl -2.525627525 -1.476960723 -2.426075566 -1.418743772 5.65E-05 0.030587891 8.73E-05 0.048830171 Idi1 -2.664603258 -2.074954329 -2.413416918 -1.879352908 1.09E-06 2.77E-05 3.67E-06 0.000117489 Ncapg2 -2.004057522 1.112948877 -2.399133592 -1.075645175 2.15E-05 0.349278661 1.74E-06 0.519966415 Snora73b -2.077090794 -2.201335155 -2.250944407 -2.385588088 0.000142982 6.86E-05 5.21E-05 2.58E-05 Mboat1 -1.987529372 -1.123243571 -2.226507579 -1.258301064 4.53E-05 0.3391227 9.20E-06 0.07087537 --- -1.897197505 1.021898072 -2.188383912 -1.12876462 0.000920401 0.888990567 0.000159395 0.4400816 Mastl -2.038171244 -1.065124882 -2.162327487 -1.130007508 0.00024041 0.669898 0.00011456 0.41320952 Tpx2 -2.146471859 -1.040495373 -2.15942025 -1.046772064 4.16E-07 0.648819214 3.79E-07 0.600459909 Fam33a -2.012038018 -1.232745663 -2.148773992 -1.316521753 3.63E-05 0.095366344 1.43E-05 0.034045055 Sgol1 -2.232502354 -1.563911659 -2.140196529 -1.499249619 0.000394539 0.021694264 0.000626067 0.034641094 Prc1 -2.148474022 -1.401144463 -2.127253683 -1.387305449 2.71E-06 0.004782935 3.14E-06 0.005813001 Atp5f1 -2.19822414 -1.119357572 -2.121918343 -1.080501902 8.00E-07 0.245543541 1.36E-06 0.41909308 Ska1 -2.388094128 -1.587293921 -2.116572079 -1.40682143 3.40E-05 0.006602928 0.000146567 0.033546316 Ercc6l -1.847842651 1.030877027 -2.099483891 -1.102149983 3.61E-05 0.77125471 4.85E-06 0.359292103 Atp5f1 -2.120307273 -1.085657261 -2.095604744 -1.073008868 1.31E-07 0.299206826 1.58E-07 0.370894034 Arhgap19 -2.202922107 -1.323139081 -2.08399993 -1.251710963 3.81E-05 0.053577084 7.86E-05 0.113030703 Hist1h4d -2.582828884 -1.378465454 -2.07512832 -1.10750376 3.66E-06 0.025310517 5.84E-05 0.438363841 Calcrl -1.360582615 -1.970055689 -2.07105626 -2.99878605 0.097049403 0.001588139 0.000907609 1.96E-05 Cenpq -3.046018994 -1.083685269 -2.042738489 1.375994397 6.73E-06 0.620524354 0.000521097 0.064307208 Hist1h4b -2.270193484 -1.301804214 -2.0410486 -1.17040494 1.85E-07 0.008244487 9.61E-07 0.087516055 Sass6 -1.814429622 -1.15499743 -2.033159643 -1.294232707 6.03E-05 0.190878506 9.88E-06 0.027658783 Vmn1r43 -1.754656364 -1.331870486 -2.031030211 -1.54165183 0.000402871 0.033373136 4.60E-05 0.00315705 Kif15 -2.052432431 -1.186873641 -2.031021405 -1.174492146 6.71E-06 0.116925881 7.87E-06 0.139006211 Ect2 -1.774673677 -1.167515072 -2.01990195 -1.328844847 0.000118034 0.17420605 1.53E-05 0.020010265 Ndufaf2 -2.051557939 -1.457373435 -2.019274036 -1.434439789 2.09E-05 0.005293637 2.64E-05 0.006968043 Hist1h4b -2.211444182 -1.269752764 -2.008961448 -1.153492533 7.53E-07 0.022790346 3.29E-06 0.148058734 --- -2.137497755 -1.648716558 -2.004027593 -1.545766991 0.00058663 0.011333596 0.001208372 0.023604831 F630043A04Rik -2.040536114 -1.326220252 -1.999534501 -1.29957178 7.86E-06 0.016198659 1.07E-05 0.023728104 Hist1h4m -2.295273477 -1.33648801 -1.995323588 -1.16183369 2.83E-07 0.006176482 2.43E-06 0.117427148 Hist1h4m -2.295273477 -1.33648801 -1.995323588 -1.16183369 2.83E-07 0.006176482 2.43E-06 0.117427148 Kbtbd8 -1.216673492 1.061355009 -1.966329234 -1.522725134 0.079505182 0.574583717 1.47E-05 0.001213004 Pola1 -1.469692677 1.146952506 -1.962691301 -1.164340577 0.004626748 0.249535406 4.09E-05 0.203796584 Hist1h4b -2.203099692 -1.293347425 -1.961130723 -1.151297593 2.28E-07 0.008490119 1.48E-06 0.11537829 Casc5 -1.900664142 -1.048307281 -1.953866772 -1.077651078 0.000151687 0.709997263 0.00010181 0.557083138 Cnot6 -1.647025714 -1.262586816 -1.951880629 -1.496284319 0.004368147 0.134234914 0.000462422 0.015846143 Kif11 -1.78622784 -1.009458281 -1.94052035 -1.096654242 5.50E-05 0.92711564 1.39E-05 0.376927084 Snhg8 -2.129107509 -2.034482266 -1.935316059 -1.849303609 0.000628735 0.001044413 0.001837746 0.003088257 Snord52 -2.250875082 -2.671586013 -1.935018278 -2.296692432 0.000257777 4.12E-05 0.001448354 0.000206282 Kpna1 -1.292639792 -1.252695553 -1.928513506 -1.868919947 0.063307662 0.098363979 0.000151521 0.000237866 Pank2 -1.755765447 1.036717616 -1.928180191 -1.05930407 1.35E-05 0.679806191 2.49E-06 0.511702677 Chek1 -1.467686436 1.245384496 -1.922520186 -1.051802438 0.000457979 0.020673036 2.12E-06 0.557248261 Esco2 -1.719360355 -1.103413463 -1.914070698 -1.228370405 0.00102145 0.463882306 0.000217344 0.138031333 Neil3 -1.9142551 -1.171484347 -1.892940884 -1.15844049 8.25E-05 0.201071598 9.76E-05 0.232919742 Rad54b -1.817760676 -1.177609355 -1.891765894 -1.225552541 0.000210481 0.19429498 0.000115135 0.112079887 Gins1 -1.825630608 -1.227711366 -1.891229625 -1.271825799 3.06E-06 0.022543332 1.60E-06 0.009512539 F730047E07Rik -1.608108497 -1.013904026 -1.891146882 -1.192358253 0.000296699 0.891012479 1.69E-05 0.097457968 G2e3 -1.887776578 -1.344094827 -1.88447064 -1.341741003 0.000377353 0.047616411 0.000386574 0.048770437 Lsm3 -1.911394502 -1.170576211 -1.872433466 -1.146715694 6.23E-05 0.190138848 8.54E-05 0.251142029 Psma1 -1.826233222 -1.097669725 -1.869641222 -1.123760395 7.67E-05 0.405134778 5.26E-05 0.300718714 Cdc7 -1.92047075 -1.379464807 -1.866843979 -1.340944958 3.54E-05 0.010585024 5.53E-05 0.017611428 Mre11a -1.664340342 -1.442381805 -1.866307129 -1.617414046 6.24E-05 0.001177775 7.59E-06 0.000109385 Terf1 -1.810830555 -1.190831875 -1.864965015 -1.226431584 0.000348663 0.187532717 0.000226042 0.127750378 --- -1.850794972 -2.385690207 -1.855807991 -2.39215203 0.00883151 0.000756055 0.008601604 0.000736936 Gsg2 -1.783662066 -1.060016153 -1.855713008 -1.102835454 8.06E-05 0.587017616 4.18E-05 0.36637881 Suv39h2 -1.59715535 1.02502168 -1.85485248 -1.132998053 0.000713111 0.822315271 5.68E-05 0.267176246 Ppil5 -2.086488976 -1.402865244 -1.840334657 -1.237361691 0.000130654 0.030188508 0.000689073 0.151044439 Zfp238 -1.626629156 -1.107710775 -1.838490781 -1.251985457 5.69E-05 0.249278053 5.40E-06 0.019539322 Spc25 -2.190631032 -1.33980348 -1.831911091 -1.120408146 1.36E-05 0.028148962 0.000178912 0.356775659 Ska2l -1.842074268 -1.308311442 -1.826533404 -1.297273727 0.000298125 0.053563507 0.000337438 0.0605247 Rps6ka5 -1.378247936 -1.010665714 -1.825007346 -1.338273256 0.020682118 0.932369307 0.00024715 0.032763577 Shcbp1 -1.667534429 -1.229032525 -1.818607198 -1.340378559 0.000662436 0.099842283 0.000166309 0.025418827 Ppp3cb -1.579488989 -1.314327158 -1.815236369 -1.510497683 0.000225325 0.010505398 1.65E-05 0.000556092 Cenpi -1.866376129 -1.407972925 -1.814085653 -1.368525584 0.000163916 0.01410282 0.00025128 0.022200341 Blm -1.567383874 -1.015551201 -1.807574084 -1.171177056 7.46E-05 0.851205086 4.16E-06 0.070959246 Ctgf -2.194134133 -1.842282105 -1.806710568 -1.516985903 0.000149578 0.001300175 0.001668833 0.016024196 Snhg1 -1.709269212 -2.082906183 -1.806597367 -2.201509744 0.003940644 0.000337211 0.001954103 0.000174593 Kif14 -1.793531993 -1.252672381 -1.801543748 -1.258268102 1.59E-05 0.025777918 1.46E-05 0.023438978 Atad5 -1.385756033 1.274063715 -1.798145237 -1.018466719 0.0369089 0.108677677 0.001008285 0.898749393 2810026P18Rik -1.872232789 -1.454330729 -1.79695991 -1.395859549 1.08E-05 0.001325241 2.20E-05 0.003130974 Atp11c -1.155633431 1.073054169 -1.793879825 -1.446610464 0.243673379 0.562300445 0.000238068 0.007838538 Fdft1 -2.006733393 -1.280885761 -1.783006923 -1.138082511 7.26E-05 0.067627746 0.000405866 0.317844994 --- -2.497341254 -1.871359837 -1.777880955 -1.33223884 4.80E-06 0.000223135 0.000474613 0.039949267 Fignl1 -1.670387745 -1.061424288 -1.77728346 -1.12934966 0.000417626 0.600053274 0.000149116 0.292264631 Dgcr8 -1.539611269 -1.059042423 -1.774013669 -1.220279282 0.000718296 0.573927584 5.36E-05 0.065801976 Mnd1 -2.02733081 -1.096115026 -1.772835685 1.043277892 0.000376506 0.553739841 0.002064642 0.783471485 Gm10124 -1.691297471 -1.119671788 -1.765929084 -1.169079366 0.000122794 0.275009132 5.71E-05 0.138866708 Fam54a -1.733026942 -1.340960754 -1.765873451 -1.36637633 0.000875086 0.040862213 0.000663823 0.031095625 Melk -1.848419507 -1.085825279 -1.758194912 -1.032824245 4.23E-06 0.343364077 1.07E-05 0.706172145 2610528E23Rik -1.603984436 -1.401656863 -1.757756649 -1.536032155 4.91E-05 0.001020485 7.71E-06 0.000125101 Rbl1 -1.730812957 -1.100552126 -1.751766989 -1.113875925 4.40E-06 0.223746201 3.46E-06 0.173894024 Hmgb1 -1.529369033 1.070794087 -1.750912696 -1.069168698 0.001877422 0.5469587 0.000185558 0.555779788 Lin7c -1.449122627 1.111123225 -1.747955619 -1.085583012 0.000422093 0.211518408 7.56E-06 0.32476952 Cks1b -1.710740159 -1.020431222 -1.738428302 -1.03694679 1.12E-05 0.804595035 8.16E-06 0.657998712 2810417H13Rik -1.774469563 -1.097638113 -1.731263722 -1.070912167 0.000142793 0.412599006 0.000214485 0.544510433 Pbk -1.810244587 -1.17329895 -1.722005065 -1.116107044 0.000254674 0.209884703 0.000549828 0.381496943 Ndc80 -1.752443652 -1.077074054 -1.713798613 -1.053322323 3.62E-05 0.441813405 5.45E-05 0.588382381 Ttc32 -1.944159043 -1.181908248 -1.709873191 -1.039479375 0.000691316 0.292638934 0.003542306 0.803617383 Nucks1 -1.4231091 1.074001125 -1.709581504 -1.118528047 0.001393294 0.433356123 3.18E-05 0.226437312 4930422G04Rik -1.350819211 1.191927109 -1.704362131 -1.058558711 0.008329896 0.094280697 9.02E-05 0.569598463 Arhgap11a -1.757640348 -1.080761917 -1.703406489 -1.04741386 2.65E-05 0.410118157 4.75E-05 0.620374762 Vmn1r45 -1.540265621 -1.364964651 -1.702968703 -1.509150142 0.000812239 0.00839358 0.000128303 0.001197782 Aurkb -2.435822577 -1.973343854 -1.701263704 -1.378252384 0.00039415 0.00328673 0.015100507 0.116408585 Cep55 -1.719812075 -1.411441764 -1.700562183 -1.395643468 1.67E-05 0.00112498 2.08E-05 0.001458279 Kif20b -1.6260584 -1.147897633 -1.692474487 -1.194783323 0.001120075 0.264344407 0.000586415 0.155861859 Msh2 -1.227187003 1.315480499 -1.689962025 -1.046843557 0.033927747 0.007167471 3.32E-05 0.60679101 Znhit3 -1.848142412 -1.485665328 -1.688344299 -1.357208497 8.08E-06 0.000575955 4.28E-05 0.004143848 Ankrd49 -1.740618883 -1.498419862 -1.686050651 -1.451444546 0.000704438 0.006968717 0.001137878 0.01138942 Ccdc99 -1.870718598 -1.816539054 -1.685442194 -1.636628604 0.000154942 0.000241067 0.000768169 0.001223918 Ttk -1.827850398 -1.108294603 -1.680972136 -1.019236776 2.33E-05 0.305249953 0.000103842 0.846442321 Bub1b -1.751774741 -1.104673042 -1.678418971 -1.05841473 7.64E-06 0.238604568 1.78E-05 0.494021109 Gemin6 -1.939385322 -1.519303787 -1.674107784 -1.311486824 8.75E-06 0.000726772 0.000113276 0.014247521 Nusap1 -1.781440671 -1.435695926 -1.673367958 -1.348598131 3.92E-05 0.002359803 0.000120878 0.008381341 Bard1 -1.508084214 1.080839062 -1.672167642 -1.02587203 0.000548384 0.41166 7.04E-05 0.784990435 Epb4.1l4a -1.539340566 -1.217728523 -1.671183871 -1.32202601 0.000117199 0.029686445 2.05E-05 0.004103842 Hjurp -2.132724303 -1.402151624 -1.670343706 -1.098161228 4.95E-07 0.001534142 3.66E-05 0.293892209 Alg13 -1.377630154 -1.050900889 -1.65735742 -1.264285905 0.014962937 0.673265951 0.000651322 0.061620858 Tmx1 -1.398132277 1.076267452 -1.656911918 -1.101110625 0.002986884 0.443352965 9.62E-05 0.318839271 Cdk1 -1.883254676 -1.345031259 -1.65633033 -1.182960594 5.61E-06 0.004954591 6.02E-05 0.07942577 Clock -1.272859879 1.130572002 -1.653139513 -1.148763644 0.023565803 0.216636382 0.000118661 0.165828092 Oip5 -1.702700881 -1.396528125 -1.650941985 -1.354076304 8.96E-05 0.004181132 0.000157967 0.007810273 Hist1h4f -1.999001046 -1.246938248 -1.645278515 -1.026292964 3.75E-05 0.078546559 0.000782743 0.826425285 Eri1 -1.365667919 1.131006363 -1.64517748 -1.065129959 0.003175623 0.180960672 5.91E-05 0.482193318 Rad51ap1 -1.707278185 -1.18915219 -1.643670934 -1.144848512 1.21E-05 0.049565737 2.62E-05 0.115263281 Fam98b -1.447919628 1.292327974 -1.642657143 1.139122091 0.031829377 0.120527522 0.006510538 0.414867556 Stk17b -1.284392502 -1.177045502 -1.641627289 -1.504423308 0.035363982 0.151237718 0.000415783 0.00198321 Phf6 -1.465209749 1.088565157 -1.6402027 -1.028355543 0.001467861 0.393887356 0.00016186 0.776130646 Snhg1 -1.634701791 -1.769884596 -1.635430055 -1.770673085 0.001392171 0.000405869 0.001382433 0.000403125 Siah1b -1.384806115 -1.043876811 -1.632905065 -1.230895584 0.003417664 0.648747643 0.000115942 0.041175986 Hist1h2bc -2.429102372 -1.704616742 -1.629325617 -1.14337533 6.67E-05 0.004564631 0.008032748 0.409884584 Rad18 -1.410713206 -1.121033882 -1.629195874 -1.294652781 0.001424437 0.208175806 6.53E-05 0.010009395 Pgm2l1 -1.393230634 1.285875733 -1.628049002 1.100410037 0.018021537 0.061568842 0.001516209 0.451707432 2410017P07Rik -1.665945836 -1.104806513 -1.625974493 -1.078298689 7.97E-06 0.198923226 1.35E-05 0.324961197 Rrm1 -1.50954612 1.048980639 -1.625836252 -1.026745822 0.000213859 0.572457958 4.35E-05 0.754398235 Birc5 -1.847035124 -1.500396336 -1.625556525 -1.32048331 8.74E-07 7.53E-05 1.19E-05 0.001973857 Cep63 -1.319928657 1.100459894 -1.624494605 -1.118390826 0.009234709 0.314670725 0.000121891 0.243053056 2810417H13Rik -1.706702968 -1.141255459 -1.615346018 -1.080165966 0.000240974 0.244913962 0.000621444 0.490185343 2610039C10Rik -1.62134252 -1.028220636 -1.61358014 -1.0232979 0.00012163 0.765166724 0.000133671 0.804658132 Plk4 -1.665217519 -1.222506792 -1.613332012 -1.184415441 0.000157289 0.062392784 0.000282532 0.110003421 Racgap1 -1.713039099 -1.205766232 -1.612246481 -1.134820778 0.000241302 0.110081372 0.000681639 0.267933032 Lsm2 -1.805534568 -1.344120328 -1.612061544 -1.200090394 1.07E-06 0.001046521 1.15E-05 0.023321624 Gm11277 -2.541331531 -1.720043092 -1.611899744 -1.09097809 6.91E-05 0.005799314 0.012510136 0.608796307 Vmn1r40 -1.385492458 1.068519275 -1.609552194 -1.087222766 0.002178018 0.45764818 8.56E-05 0.351541596 Nampt -1.502528923 -1.15391514 -1.604908311 -1.232540666 0.001348586 0.18120665 0.000390958 0.05918973 Depdc1a -1.877234004 -2.012180043 -1.604463848 -1.719801649 0.00047608 0.000187669 0.004287007 0.001603154 Gemin6 -1.879232834 -1.600048636 -1.603108189 -1.364945857 1.85E-05 0.000321924 0.000310546 0.007241887 Depdc1a -1.813886309 -1.97739105 -1.601544034 -1.745908123 0.000977022 0.000310769 0.005380942 0.001640922 Stard4 -1.436680305 -1.320336813 -1.601379642 -1.471698669 0.00027454 0.00237772 2.15E-05 0.000152275 Gm11277 -2.512296936 -1.711084962 -1.601158677 -1.090523375 6.60E-05 0.005528399 0.012301918 0.604420511 Zfp367 -1.426232824 1.116944096 -1.60083932 -1.004907016 0.000414703 0.17224377 2.85E-05 0.950096178 Hells -1.331795283 1.197194647 -1.596529158 -1.001323977 0.008955104 0.077144625 0.000219092 0.988995033 B3galnt2 -1.373819421 -1.366744239 -1.596043031 -1.587823396 0.00361177 0.004040493 0.000155137 0.000172027 Mki67 -1.615076352 -1.162890262 -1.592637267 -1.14673363 0.000943773 0.208675387 0.00119497 0.251600824 Hist1h2be -2.40738914 -1.684659741 -1.592021901 -1.114076307 5.86E-05 0.004536953 0.009358473 0.494737047 Zfp449 -1.494140542 -1.284296801 -1.591065324 -1.367609035 0.00165332 0.029395497 0.00051146 0.008961868 Pold3 -1.40751576 -1.013606426 -1.588385475 -1.143857689 0.00080551 0.868302342 5.10E-05 0.115512394 Dsn1 -1.460906698 -1.091489442 -1.587012766 -1.18570726 0.000698205 0.332673713 0.000120185 0.071397288 Wee1 -1.272317269 -1.044737866 -1.58618207 -1.302461666 0.036552261 0.680348387 0.000589816 0.023783546 Cks2 -1.922553881 -1.469364643 -1.582837024 -1.209726698 5.14E-05 0.004392509 0.001212136 0.114824176 Orc2l -1.327259784 -1.277978809 -1.582622251 -1.523859702 0.011319627 0.024210501 0.000333701 0.000697295 Usp1 -1.366644228 1.037302233 -1.5809755 -1.115229774 0.005648156 0.706813322 0.000296124 0.272294879 Brca1 -1.303736944 1.161308807 -1.579052415 -1.042938871 0.02533536 0.17953359 0.000735867 0.697025712 Cep57 -1.614473717 -1.231991154 -1.578925461 -1.204864582 0.000177769 0.044364897 0.000274271 0.068496624 Eif5b -1.208746663 1.573748411 -1.57527949 1.207571832 0.06555388 0.000305689 0.000299915 0.066785522 Dhfr -1.638573976 -1.162745411 -1.573175539 -1.116338148 0.000348362 0.172270076 0.000726425 0.311387261 Gm11277 -2.443484854 -1.700215548 -1.572372506 -1.094081748 7.79E-05 0.005467251 0.014190256 0.586010306 4930422G04Rik -1.246141871 1.026701547 -1.571830987 -1.228553691 0.020345036 0.758237461 0.000102096 0.02818864 Hmgcs1 -1.585597093 -1.117713715 -1.571599821 -1.107846806 3.92E-05 0.174081003 4.77E-05 0.208640556 Polr3g -1.238104673 -1.035322929 -1.571594308 -1.314192296 0.055009266 0.738392247 0.000587314 0.018094956 Tmem168 -1.162752003 1.208356731 -1.569770889 -1.11725938 0.174317366 0.094154171 0.000788338 0.310302761 Mad2l1 -1.404988194 -1.024845038 -1.569366815 -1.144748261 0.006412774 0.820132616 0.000832075 0.222874087 Nuf2 -1.582364187 -1.2232805 -1.56799771 -1.212174187 0.000237058 0.04875797 0.000284029 0.058401246 Cks2 -1.873241314 -1.420281428 -1.565061609 -1.186621243 8.12E-05 0.008230134 0.001538332 0.155127497 Cenpf -1.631619094 -1.051857556 -1.563843043 -1.0081643 0.000266829 0.623723342 0.000587615 0.93683549 Rab18 -1.376405229 1.012411223 -1.562976316 -1.121628749 0.007703907 0.905914293 0.000683613 0.281783545 Higd1a -1.62626569 -1.388249607 -1.558510576 -1.330410958 0.00048081 0.008545078 0.001026968 0.018616325 Rad51 -1.364876387 1.074453431 -1.558366932 -1.062646477 0.000382766 0.299977725 1.20E-05 0.377805947 Zwilch -1.649332532 -1.157848633 -1.555985439 -1.092318001 0.000600845 0.216118482 0.001620785 0.44794008 6330403K07Rik -2.243509483 -2.009888911 -1.555888521 -1.393871124 2.09E-07 1.18E-06 0.00014549 0.001656912 Tesk2 -1.186553062 -1.246688127 -1.551912046 -1.630563676 0.086188272 0.032222363 0.000327559 0.000123288 Tnnt2 -1.358892212 1.392216638 -1.551484587 1.219394871 0.047245993 0.034191756 0.007660845 0.180921175 Wdr5 -1.383889766 -1.07930653 -1.551318185 -1.209885273 0.001527126 0.370455517 0.00011391 0.036864891 Kctd9 -1.241246511 -1.165232183 -1.550512684 -1.455558798 0.037159415 0.125248184 0.000370891 0.00134343 Gins3 -1.480102006 1.087344037 -1.547545849 1.039956322 0.001161218 0.398206787 0.000478382 0.68958012 6330503K22Rik -1.45786881 -1.007090326 -1.546194199 -1.068105175 0.001213781 0.940438872 0.000363208 0.489805225 Wdr76 -1.319832457 1.10368202 -1.544664067 -1.060403792 0.00686278 0.278082793 0.000214681 0.513085661 Gm4383 -1.493897976 -1.157948242 -1.54404872 -1.196821021 0.000646013 0.131585464 0.000327234 0.070045866 Nasp -1.442472762 1.062200827 -1.544018162 -1.007715986 0.000819232 0.494177962 0.000185972 0.930002146 Il1rl1 -1.756973462 -1.102505945 -1.541867442 1.033563643 1.85E-06 0.194346831 3.22E-05 0.651588243 Aurka -2.09562441 -1.488157735 -1.537560184 -1.091861724 1.17E-05 0.003083186 0.001732264 0.441790462 Asph -1.405930552 1.082113084 -1.53754301 -1.010626673 0.00262978 0.410627094 0.000412284 0.911140797 Lsm6 -1.454908266 -1.04523238 -1.536479337 -1.10383451 0.000562086 0.606970146 0.000168285 0.259725877 --- -1.564157695 -1.785782683 -1.535149812 -1.752664682 0.000767893 7.40E-05 0.001085037 0.000101647 Utp15 -1.400173349 -1.028457178 -1.53423396 -1.126927556 0.000576343 0.716401192 6.37E-05 0.137011373 Nup37 -1.592608092 -1.311731669 -1.531893674 -1.261725001 0.000801386 0.026091253 0.001597691 0.051189725 Mir16-2 -1.166345034 -1.04718667 -1.531841916 -1.375342962 0.13447365 0.641157402 0.000622525 0.005445101 Nup107 -1.392383162 1.086246039 -1.529182576 -1.011049392 0.000874068 0.308619722 9.52E-05 0.89034985 Sec61a2 -1.159747223 1.227755468 -1.526882847 -1.072335042 0.151240905 0.054284468 0.000708502 0.485870176 Kif22 -2.10839338 -1.295818455 -1.525440733 1.066625947 4.21E-06 0.023615056 0.001026182 0.536850033 Ppwd1 -1.111371222 1.294516893 -1.524138212 -1.059393936 0.275483027 0.015068646 0.000491416 0.545031336 Scyl3 -1.444011047 -1.050252342 -1.519750092 -1.105338562 0.001916522 0.617825294 0.000685354 0.315088699 Nup85 -1.582365071 -1.334478131 -1.515769927 -1.278315514 0.00012335 0.005157817 0.00030465 0.013661493 Hist1h2bb -1.938949551 -1.623163727 -1.515416022 -1.268608725 5.63E-06 0.000138282 0.000543746 0.022774462 Lsm6 -1.466142115 -1.107826291 -1.51414014 -1.144093903 0.00116587 0.293550012 0.000603268 0.173460808 Ccnb1 -1.683543506 -1.340356384 -1.513819893 -1.205230605 0.000185703 0.013210509 0.001298731 0.091867842 Ddah1 -1.182692075 1.193979079 -1.512832123 -1.071327699 0.087428229 0.072607674 0.00048441 0.462611921 9930111J21Rik2 -1.095875684 -1.468742038 -1.512827285 -2.027559387 0.476421655 0.008408462 0.005274787 6.42E-05 Hist1h2bm -2.130077635 -1.772264466 -1.511860489 -1.257896228 2.07E-05 0.000308374 0.003975534 0.076265302 9930111J21Rik2 -1.110156484 -1.536025985 -1.511552461 -2.09140233 0.413878856 0.003921113 0.005061701 3.85E-05 Umps -1.34479189 -1.156718744 -1.509806263 -1.298655366 0.001977668 0.082643239 0.000120175 0.004778408 Mtbp -1.539418747 -1.118832594 -1.508065756 -1.096045585 0.00019432 0.211766447 0.000302405 0.303180561 Naa38 -1.539163295 -1.119622041 -1.507514877 -1.096600269 0.000610951 0.266772895 0.000917807 0.361123561 Haus6 -1.291254651 -1.356940829 -1.507198565 -1.583869819 0.031609795 0.012869694 0.001861691 0.000758244 Vrk1 -1.370020986 1.027102846 -1.504241041 -1.068996494 0.00091335 0.72621818 9.05E-05 0.387899655 Snora21 -1.59788607 -1.805106994 -1.500789989 -1.695419064 0.0058317 0.001107926 0.013748381 0.002590616 E330016A19Rik -1.222023617 1.21519183 -1.500711724 -1.01058497 0.021763097 0.025018981 0.000133724 0.893896551 Ccna2 -1.54173133 -1.055371497 -1.496613298 -1.024486554 6.70E-05 0.495255676 0.000132908 0.757879774 Fbxo5 -1.614287073 -1.257812455 -1.495503955 -1.165259596 0.00020138 0.031124037 0.000904729 0.132150879 Etf1 -1.278151058 1.145682781 -1.494863629 -1.020833716 0.015491687 0.148524169 0.000498578 0.819889639 Hist2h4 -1.798594271 -1.346672397 -1.491915436 -1.117050893 1.57E-05 0.005493945 0.000606617 0.241741523 Snord49a -1.925126937 -2.035686051 -1.491471115 -1.577125583 0.001225465 0.000630967 0.027009813 0.013819481 Fabp5 -1.589740748 -1.370591146 -1.489618413 -1.284270917 3.54E-05 0.001171465 0.000155099 0.006095931 Inhba -1.067514792 -1.120439303 -1.48729931 -1.561035608 0.480233194 0.22757883 0.000621415 0.000227336 Hsd17b7 -1.492852075 -1.622295958 -1.483488414 -1.612120382 0.003044219 0.000716692 0.00340116 0.000798273 Agpat9 1.044703365 -1.665235431 -1.482045535 -2.578280616 0.67223136 0.000191172 0.001692774 2.46E-07 Fez1 -1.72861439 -1.212863738 -1.477436123 -1.036627202 0.000279047 0.110707057 0.004018492 0.755412421 Cdca2 -1.701149887 -1.261926719 -1.474069921 -1.093476967 3.30E-05 0.019489774 0.000619657 0.327312177 Fabp5 -1.558858077 -1.386882409 -1.472111008 -1.309705413 5.36E-05 0.00085755 0.00020096 0.00364256 Ccnb1 -1.706249906 -1.392015283 -1.471041966 -1.200124842 0.00015682 0.006713621 0.002354214 0.100941615 Cdkn2d -2.013613963 -1.217206729 -1.470714128 1.12482149 1.02E-06 0.035581494 0.000455339 0.18530969 Ccdc14 -1.521645519 -1.169020292 -1.467964076 -1.127778955 0.00057223 0.120311598 0.001187586 0.223315859 Gm11277 -2.142034593 -1.616191222 -1.467935957 -1.107575581 7.60E-05 0.003618975 0.014402503 0.468709277 Gm11277 -2.142034593 -1.616191222 -1.467935957 -1.107575581 7.60E-05 0.003618975 0.014402503 0.468709277 Ubtf -1.664609837 -1.725186182 -1.467702318 -1.521113058 0.000632165 0.000353246 0.005246613 0.002856801 Haus1 -1.650629796 -1.261827301 -1.467517643 -1.121846843 0.000352539 0.046693643 0.002953512 0.298522521 Rad54l -1.613255946 -1.017604865 -1.466758106 1.080850437 6.51E-05 0.839846922 0.00050295 0.374690302 Zfp639 -1.571618297 -1.153920697 -1.466432962 -1.076691045 0.000597511 0.182901313 0.002216833 0.48122266 Ott -1.405630172 -1.692170805 -1.462923606 -1.761143625 0.005786049 0.00019098 0.00272167 9.58E-05 Ott -1.405630172 -1.692170805 -1.462923606 -1.761143625 0.005786049 0.00019098 0.00272167 9.58E-05 Prim2 -1.607122556 -1.110508335 -1.460389728 -1.00911717 2.26E-05 0.188363957 0.000205605 0.906331198 Ott -1.398995622 -1.679278695 -1.458018346 -1.750126381 0.005198466 0.000164936 0.002327771 7.95E-05 Ott -1.385660277 -1.665454052 -1.455682134 -1.749614787 0.006138682 0.000185808 0.002345691 7.74E-05 Hist1h2be -1.569662217 -1.309809257 -1.453846102 -1.213166159 7.54E-05 0.005088827 0.000420815 0.032188733 Tmem194 -1.491764986 -1.321876818 -1.453042392 -1.287564107 0.000656391 0.008706639 0.001140936 0.015318869 Ccnb1 -1.693348797 -1.384637737 -1.451534319 -1.186907977 0.000279997 0.009984231 0.004252601 0.138585728 Ott -1.383108221 -1.654099912 -1.45014658 -1.734273063 0.012392601 0.000560555 0.005423091 0.000255497 Ott -1.394029673 -1.690209768 -1.449975839 -1.758042439 0.005368259 0.000139169 0.002486157 6.95E-05 --- -1.664079195 -1.985669794 -1.449613983 -1.729758241 0.007446481 0.000886325 0.038687431 0.004653806 --- -1.664079195 -1.985669794 -1.449613983 -1.729758241 0.007446481 0.000886325 0.038687431 0.004653806 Selk -1.599959494 -1.594513464 -1.448380114 -1.443450039 0.001210462 0.001281553 0.006537855 0.00692904 Med4 -1.329029605 -1.429177727 -1.443947476 -1.552755156 0.009910565 0.002203431 0.001783846 0.000412482 Dtymk -1.648512598 -1.213524558 -1.443642801 -1.062713135 7.69E-06 0.018016147 0.000173671 0.413224265 Tyms -1.520442782 -1.026817152 -1.443638381 1.025695728 6.94E-05 0.728603695 0.000241529 0.73934817 Polr2h -1.521739139 -1.377448394 -1.437903482 -1.301562003 0.00017696 0.001732055 0.000635455 0.006672586 OTTMUSG00000019001 -1.400564276 -1.687235678 -1.437818946 -1.732115738 0.004942948 0.000145511 0.002958906 9.13E-05 Snora74a -1.439101676 -2.060574958 -1.436855907 -2.057359358 0.034468936 0.000385705 0.035132554 0.000393053 Nsl1 -1.723226848 -1.277076156 -1.436375106 -1.064491538 0.000530637 0.063460726 0.009930852 0.614125027 Cyp51 -1.536807302 -1.251083601 -1.435323524 -1.168467719 0.000246589 0.023135505 0.00107526 0.097844211 Hist1h1b -1.852165376 -1.334496762 -1.434675607 -1.033692767 5.32E-05 0.017592415 0.004655521 0.761415196 --- -1.638376601 -1.975636664 -1.434359674 -1.729622822 0.006578734 0.000619189 0.035149487 0.003292739 --- -1.638376601 -1.975636664 -1.434359674 -1.729622822 0.006578734 0.000619189 0.035149487 0.003292739 Cks2 -1.703890509 -1.380554522 -1.432348603 -1.160541321 0.000122271 0.006557585 0.003190777 0.162140054 Ak5 -1.223517047 1.403174614 -1.432253137 1.198676418 0.070801926 0.005505283 0.003717684 0.100765469 Ott -1.397861877 -1.686443803 -1.431301899 -1.726787359 0.004561729 0.000124022 0.002850443 8.11E-05 Fam83d -1.854556381 -1.265202913 -1.425416229 1.028343385 0.000563774 0.111901038 0.022952506 0.843005482 Pms2 -1.517675495 -1.3038416 -1.42532915 -1.224506454 0.000427749 0.011165424 0.001614395 0.042460679 Snora21 -1.524248864 -1.816853347 -1.4225717 -1.69565759 0.006238289 0.000459104 0.017594082 0.001260595 Sc4mol -1.548294721 -1.546581899 -1.421468767 -1.419896248 0.001069973 0.001091768 0.005185496 0.005293452 Ppih -1.511483538 -1.357544361 -1.419917477 -1.275303975 0.000116478 0.001553724 0.000512162 0.007542895 Ott -1.398104607 -1.702472776 -1.419701199 -1.728770958 0.005356429 0.000132429 0.003976611 0.000101064 Gm9078 -1.541798301 -1.177840002 -1.41750503 -1.082887513 0.000162965 0.073331176 0.00105445 0.361820038 Pttg1 -1.583002503 -1.20452618 -1.411145569 -1.073758113 0.000580748 0.093748448 0.005047586 0.502523458 Prr11 -1.493435972 -1.495988468 -1.409696187 -1.41210556 0.001507291 0.001458826 0.004592673 0.004442924 Cdc25b -1.881446539 -1.435485413 -1.401136356 -1.069023625 0.000398049 0.019027791 0.026823406 0.631513914 Mrpl18 -1.603071956 -1.770924219 -1.396225485 -1.542419551 0.000254458 4.07E-05 0.003964005 0.000536942 Mbtps2 -1.129945481 -1.255401648 -1.39594353 -1.550933065 0.164334293 0.016333438 0.001334637 0.000124627 Mecom -1.529871113 -1.281528148 -1.395831855 -1.169247394 0.000409243 0.017451211 0.002801612 0.111138323 Gm16516 -1.486094665 -1.62285511 -1.392055078 -1.520161366 0.001288051 0.000236475 0.004738659 0.000825833 Luzp4 -1.469654905 -1.795257725 -1.390649515 -1.698748649 0.003898528 0.000127673 0.010384064 0.000316949 --- -1.637485677 -2.491751746 -1.388352967 -2.112648055 0.000706962 1.48E-06 0.012104742 1.34E-05 D2Ertd750e -1.783015063 -1.230759538 -1.386067501 1.045195235 8.44E-05 0.068935425 0.0079433 0.680908241 Snx25 -1.218362738 -1.541572109 -1.382128095 -1.748781423 0.033222755 0.000146954 0.001730611 1.12E-05 6720489N17Rik -1.797655649 -1.814352501 -1.380084665 -1.392903065 0.001275402 0.001127706 0.044101059 0.039143218 Ube2t -1.632734602 -1.550042983 -1.376205198 -1.30650579 0.000202099 0.000543686 0.005782758 0.016419639 --- -1.59359881 -1.970311378 -1.37217982 -1.696550911 0.008535054 0.000561449 0.056557181 0.003788662 Sqle -1.54685076 -1.363712168 -1.369725402 -1.207557475 4.51E-05 0.000992789 0.000886165 0.024222389 Ott -1.455248534 -1.790299622 -1.368496271 -1.683573836 0.004224987 0.000116862 0.01274692 0.000325522 Spc24 -1.589241963 -1.357057816 -1.363128575 -1.163979011 0.000252729 0.006276083 0.005719176 0.131789926 H1f0 -1.554047103 -1.353510151 -1.36265352 -1.18681433 6.11E-05 0.00165539 0.001398366 0.04486803 Exd2 -1.147927697 -1.375045359 -1.359403259 -1.628361392 0.093194026 0.000991886 0.00132452 1.88E-05 Zfp825 -1.364986347 -1.781109045 -1.358207883 -1.772264133 0.040743152 0.000945069 0.043596922 0.001013175 Snora61 -1.793568083 -2.208425905 -1.354261444 -1.667506288 0.001129253 7.58E-05 0.052048184 0.003061665 Zmynd17 -1.574032827 -1.25664113 -1.352236519 -1.079568354 0.00085977 0.05131127 0.01384548 0.486322151 Hyls1 -1.335742784 -1.617213733 -1.349394954 -1.633742721 0.016866736 0.000508778 0.013999151 0.000424962 Golga1 -1.687884253 -1.407044484 -1.347661883 -1.123430245 2.08E-05 0.001082561 0.002985247 0.182533236 Gmeb1 -1.491342349 -1.225781316 -1.346226858 -1.106506316 0.000553379 0.039356336 0.005122356 0.277037172 Cenph -1.496479435 -1.178490889 -1.344660065 -1.058931782 0.00043665 0.082612357 0.004633175 0.524674042 Mrpl49 -1.491287027 -1.206559867 -1.344175488 -1.087535912 0.000468567 0.05065633 0.004656135 0.355065248 Tmem107 -1.626588603 -1.227985057 -1.340618622 -1.012093428 0.000568359 0.081321482 0.018010405 0.913917007 0610007P14Rik -1.610757254 -1.419163627 -1.339610752 -1.180269001 9.43E-05 0.00139036 0.005047546 0.080167789 Cacna2d1 -1.295324108 -1.65412569 -1.338972816 -1.709864982 0.06307319 0.0015532 0.039031879 0.000940894 Hirip3 -1.574349605 -1.259666402 -1.332652896 -1.06628037 0.000317035 0.029748866 0.009419494 0.511471956 B130024G19Rik -1.880892447 -2.041381365 -1.332593934 -1.446298766 5.56E-05 1.59E-05 0.020964232 0.004877511 Tinf2 -1.614565805 -1.35229674 -1.331876694 -1.115527472 1.72E-05 0.001231683 0.001832427 0.164614364 Gm10589 -1.594676668 -1.629122716 -1.323501158 -1.35208964 0.000135732 8.85E-05 0.007365308 0.004592465 Ammecr1 1.0405695 -2.111823691 -1.321712378 -2.904462054 0.716077164 7.16E-06 0.021061705 1.17E-07 Agps 1.046438364 -1.374092604 -1.320085921 -1.898155793 0.613760779 0.002890838 0.007103063 4.43E-06 --- -1.668444304 -2.291442848 -1.316663044 -1.808306162 0.005328858 0.000108693 0.097842537 0.001918378 Oxsr1 -1.164171281 -1.484511142 -1.311595224 -1.672501078 0.068751112 0.000161831 0.003463301 1.15E-05 Slc7a3 -1.446706293 -1.663077796 -1.30733508 -1.502862021 0.010755699 0.001210646 0.050828798 0.00590908 Tube1 -1.609248032 -1.237375549 -1.306623373 -1.004682796 0.000240373 0.045377342 0.01545458 0.962191832 --- -1.463861172 -2.060735356 -1.305260548 -1.837466975 0.027306048 0.000368907 0.106709733 0.00152576 4933409K07Rik -1.161351765 -1.668107859 -1.297821867 -1.86412672 0.116416558 5.59E-05 0.01137389 7.20E-06 Nenf -1.535618824 -1.232024201 -1.295678052 -1.039520154 0.000588992 0.049096849 0.018197364 0.694619395 4933409K07Rik -1.144133105 -1.650837834 -1.294838463 -1.868286403 0.12867178 3.42E-05 0.007947514 3.21E-06 Cd200 -1.461678543 -1.942995338 -1.291943605 -1.717368305 0.002182832 1.36E-05 0.024003725 0.000108417 Elovl6 -1.548425648 -1.58465263 -1.28792086 -1.318053069 0.000204216 0.000126357 0.011918847 0.007080055 4933409K07Rik -1.160542183 -1.686181097 -1.284762686 -1.866664208 0.110190461 3.58E-05 0.012453061 5.43E-06 Papd4 -1.082098117 -1.440966341 -1.272510883 -1.694527809 0.498722292 0.006337581 0.052495954 0.000398134 D10627 -1.139414061 -1.683746093 -1.270184544 -1.876989532 0.335501253 0.001406037 0.089202053 0.000289667 Tagap1 -1.321942307 -1.521536107 -1.269556836 -1.461241202 0.009402939 0.000487532 0.022074769 0.00112394 4933409K07Rik -1.146419398 -1.605495486 -1.258701464 -1.762740164 0.115500091 4.79E-05 0.013593892 7.27E-06 --- -1.354028588 -1.762732253 -1.258676688 -1.638599076 0.019600738 0.000229962 0.065088228 0.000759512 Xlr3a -1.632169192 -1.721667004 -1.25745393 -1.326404732 0.00240415 0.001094476 0.105180248 0.050920803 Gm3893 -1.05590496 -1.463872021 -1.256164018 -1.741504615 0.609177493 0.002622561 0.046009222 0.000112301 Mrpl18 -1.625122792 -1.998160486 -1.256034674 -1.544350289 0.000164443 4.35E-06 0.03085755 0.000444734 Cept1 -1.060432465 -1.647592722 -1.255506059 -1.950678344 0.613305306 0.000631724 0.065054836 4.27E-05 S100a7a -1.331445166 -2.454274264 -1.246191197 -2.297124254 0.030464751 2.94E-06 0.085260472 6.86E-06 Styk1 -1.027836119 -1.377043638 -1.238388349 -1.659131029 0.752014633 0.002191874 0.025231239 3.88E-05 Gm3893 -1.075155662 -1.528326324 -1.236946963 -1.758311538 0.506989777 0.001395917 0.065760516 0.00011836 Gm3893 -1.075155662 -1.528326324 -1.236946963 -1.758311538 0.506989777 0.001395917 0.065760516 0.00011836 Rpa1 -1.31214933 -1.615524921 -1.235011158 -1.520552011 0.027330499 0.000683335 0.076103243 0.001980578 Gem -1.237991634 1.229331902 -1.23495841 1.232351307 0.015213574 0.018168117 0.016188529 0.017077078 Wdr12 -1.189729456 -1.480498096 -1.230392353 -1.531098962 0.065631106 0.000505303 0.031932527 0.000245325 Pstk -1.436838515 -1.792750369 -1.228996128 -1.533424417 0.02459507 0.001202883 0.173432337 0.010175522 Immp2l -1.133155201 -1.499625447 -1.22834698 -1.625602907 0.243392655 0.001499575 0.065029259 0.000334546 Sh3bgrl -1.288136 -1.916052407 -1.227938205 -1.826510519 0.069029305 0.000182687 0.132414635 0.000363687 Gm6653 -1.614418158 -1.469358427 -1.225693128 -1.115561367 1.97E-05 0.000171325 0.017572056 0.169612128 1810006K21Rik -1.430591522 -1.636465897 -1.223560226 -1.399641025 0.00811612 0.000837749 0.103835515 0.011765904 2410129H14Rik -1.11803378 -1.550854969 -1.221770201 -1.694750571 0.369265469 0.002696356 0.118227931 0.000645148 Qk -1.097641259 -1.620114945 -1.218074892 -1.797874597 0.217243645 1.12E-05 0.016228775 1.27E-06 Snhg1 -1.879888526 -1.99683981 -1.217692048 -1.293446885 0.002787975 0.001413898 0.276226925 0.161074941 Spag5 -1.696397798 -1.411532871 -1.211272746 -1.007871679 3.31E-05 0.001538266 0.046309469 0.929908485 4933409K07Rik -1.139839211 -1.617672364 -1.208580984 -1.715231445 0.13322613 4.44E-05 0.036967327 1.35E-05 Tasp1 -1.296986225 -1.513387487 -1.203055727 -1.403784749 0.01347129 0.00050789 0.063962234 0.00246805 Xlr3b -1.546517057 -1.726599092 -1.202290453 -1.342289498 0.002081824 0.000333942 0.132681176 0.023199235 4933409K07Rik -1.126381225 -1.601407612 -1.202173439 -1.709163517 0.162460868 4.63E-05 0.038841221 1.21E-05 Ssna1 -1.594243283 -1.495566839 -1.201583625 -1.127211037 0.000880531 0.002714471 0.118707612 0.296518653 Psph -1.507018781 -1.823654049 -1.193743037 -1.444556864 0.002512696 9.98E-05 0.134123708 0.005314689 Bnip3 -1.277603273 -3.091561277 -1.192047542 -2.884532389 0.04520325 9.26E-08 0.136931491 2.00E-07 Csrp2 -1.659556643 -1.57747984 -1.186396226 -1.127720549 0.000244138 0.000612873 0.120388377 0.264032072 Rnu73a -1.333556632 -1.880153605 -1.184297657 -1.669716497 0.037703357 0.000190151 0.1984206 0.001133403 Mrpl3 -1.114704834 -2.20516423 -1.181594294 -2.337488269 0.35753778 7.71E-06 0.165992147 3.52E-06 Bnip3 -1.316882864 -2.580364724 -1.180546205 -2.313220003 0.060059839 6.36E-06 0.237345466 2.35E-05 Eef1e1 -1.170663112 -1.614430635 -1.179583945 -1.626733121 0.140901114 0.000327123 0.124155717 0.000284419 Zc3h12c -1.082492312 1.570540508 -1.178936596 1.44206061 0.497176974 0.001440882 0.169966537 0.006292346 --- -1.553653289 -1.587814207 -1.178475081 -1.204386776 0.000717288 0.000477881 0.128987549 0.089165421 Pmvk -1.693579868 -1.811082237 -1.178459366 -1.260222128 0.000164985 5.20E-05 0.133141962 0.041506542 Ccdc43 -1.132939444 -1.5551527 -1.174061114 -1.611599207 0.208055877 0.000377027 0.111948582 0.000187665 6720463M24Rik -1.579561308 -1.439773262 -1.172573231 -1.068802824 0.000382264 0.002352711 0.126864853 0.508286277 Polh -1.442160159 -1.555351545 -1.172412868 -1.264432493 0.003541664 0.000862914 0.149732176 0.041338232 Sms -1.278563876 -1.493615832 -1.172265639 -1.369438438 0.014548233 0.00046477 0.092641326 0.003128918 --- -1.349259468 -1.741348272 -1.172210944 -1.512850235 0.042270617 0.001029574 0.25515143 0.008078563 Mrto4 -1.48535903 -1.578857972 -1.171493542 -1.245235583 0.001740574 0.000550834 0.143860655 0.050076405 4933403F05Rik 1.01159899 -1.631844106 -1.169208969 -1.930097252 0.904946646 0.000152507 0.121845612 7.67E-06 Sms -1.27831971 -1.514961872 -1.168856891 -1.385235328 0.016052066 0.000400027 0.103545518 0.00274605 Wdr12 -1.122263883 -1.482411139 -1.168453056 -1.543422943 0.147342499 0.000133057 0.057533742 5.16E-05 Hnrnph2 1.041442652 -1.460156582 -1.168232659 -1.776495589 0.626186281 0.000398076 0.077529971 6.41E-06 Ndufa2 -1.341167034 -1.503720398 -1.164067008 -1.305155332 0.010336052 0.001068901 0.147118608 0.017709924 Hnrnph2 1.065447234 -1.516451197 -1.159038928 -1.872657727 0.454407169 0.000185833 0.095118647 2.71E-06 Fam162a -1.265389871 -1.767011533 -1.158426714 -1.617646395 0.011324703 6.24E-06 0.089683752 3.70E-05 Mrto4 -1.485895963 -1.5879318 -1.155165087 -1.234489777 0.004327001 0.001410605 0.234918995 0.091531006 Ppp2r3c -1.156888575 -1.521467775 -1.15271214 -1.515975188 0.09386867 0.000147616 0.101481904 0.00016005 Lsm7 -1.415735558 -1.635006223 -1.152552044 -1.33106056 0.002937537 0.000171172 0.163224761 0.01036502 Snora65 -1.479221094 -2.017384564 -1.151961118 -1.571062357 0.01241908 0.000155614 0.316770842 0.00519764 Nop16 -1.338256177 -1.638536484 -1.145741925 -1.402825541 0.024197595 0.000777308 0.257092781 0.010900388 Lsm7 -1.407939892 -1.631450819 -1.143851148 -1.325437899 0.002533275 0.00012652 0.170398223 0.009114805 Tpm3 -1.076264992 -1.456982374 -1.141602996 -1.545433006 0.478032031 0.002287194 0.210292146 0.000736577 Zfp579 -1.325638628 -1.503077201 -1.14036619 -1.293005789 0.009836238 0.000724667 0.18513124 0.016519222 Gmfb 1.011214938 -1.512936039 -1.137430826 -1.740159427 0.922573953 0.002571421 0.272564981 0.000239894 Rnf7 -1.1558308 -1.747457886 -1.135768789 -1.717126873 0.135128851 2.89E-05 0.184979506 4.00E-05 Tgs1 1.036556082 -1.289198802 -1.130487764 -1.510701163 0.712268601 0.018758059 0.219607772 0.000726815 Usp46 1.066083034 -1.395744194 -1.129716272 -1.68099432 0.605796871 0.015802742 0.331475784 0.000784293 Hars -1.019140746 -1.393820008 -1.128332355 -1.543155073 0.803996224 0.000595692 0.129845595 5.06E-05 Dnajc2 -1.002880148 -1.38243731 -1.127267716 -1.553901483 0.975222234 0.003214568 0.209226646 0.000272873 Snord58b -1.557390155 -2.116796242 -1.126217606 -1.530748855 0.018669815 0.00050962 0.486321543 0.022825951 Myct1 -1.06014152 -2.632489358 -1.123938894 -2.790907744 0.548009088 8.63E-08 0.238540944 4.19E-08 Snord58b -1.615496648 -2.209648534 -1.123148759 -1.536223558 0.014310757 0.00040687 0.508616419 0.025312081 --- -1.34019464 -1.794633537 -1.122526201 -1.503157158 0.065925395 0.001390218 0.443722619 0.01493967 Gm9457 -1.246841003 -1.589064632 -1.119358474 -1.426591648 0.076009925 0.001290395 0.34365451 0.008137445 Mrps17 -1.461596309 -1.497181895 -1.111414907 -1.138474603 0.00032833 0.000188483 0.207937477 0.127441354 Utp14a 1.061810742 -1.488623455 -1.109081274 -1.753054205 0.489724616 0.000353503 0.241089908 1.22E-05 Nars 1.074185936 -1.670064804 -1.108615092 -1.988811268 0.444568722 6.55E-05 0.276138041 2.95E-06 Avpi1 -1.401034913 -1.774422213 -1.107607931 -1.402794533 0.006216763 8.56E-05 0.344965094 0.006071199 Zfp57 -1.3403608 -1.714976998 -1.099875066 -1.40727813 0.021927047 0.000322815 0.415541965 0.009476476 Insig1 -1.422544509 -1.550251774 -1.096627159 -1.195075576 0.003442027 0.000647825 0.371926822 0.096641428 3830403N18Rik -1.10493031 -2.125444118 -1.096088341 -2.108435705 0.462107436 5.74E-05 0.498267919 6.38E-05 BC048355 -1.42536229 -1.540662039 -1.093500154 -1.181955063 0.005877264 0.001446049 0.425663605 0.147376309 Senp2 1.099376868 -1.381129129 -1.092168605 -1.658328514 0.230592975 0.000801819 0.262921071 1.12E-05 --- -1.313161963 -2.076893834 -1.089582281 -1.723280741 0.1109152 0.000457334 0.600147416 0.004387436 Cdk12 -1.161590483 -2.021946627 -1.084902426 -1.888457967 0.196977838 1.89E-05 0.473112874 5.37E-05 9430008C03Rik -1.45417251 -1.92438722 -1.080970633 -1.430508455 0.001679174 9.41E-06 0.432012346 0.002343626 Snrnp25 -1.319764366 -1.70322157 -1.079106482 -1.392640599 0.015282262 0.000116452 0.460159065 0.005321966 1810022K09Rik 1.154405215 -1.474382239 -1.069977982 -1.821139489 0.279914687 0.008959897 0.604646661 0.000361475 Arfrp1 -1.247641684 -1.507586537 -1.066222249 -1.28836855 0.042608889 0.001028526 0.527919834 0.022985888 --- -1.226799664 -1.500694058 -1.064971023 -1.302735673 0.046397467 0.000699428 0.511441249 0.013517609 Ptcd3 -1.007181676 -1.441827175 -1.06317164 -1.5219794 0.940576907 0.00171578 0.52648259 0.000568333 Xlr -1.0107762 -1.763998309 -1.061209445 -1.852013994 0.936954709 0.000816793 0.662187424 0.000407909 2700094K13Rik -1.678432697 -1.845913625 -1.059943787 -1.165709344 7.92E-05 1.42E-05 0.544169876 0.124106835 Sec23a 1.159030128 -1.633164898 -1.059874818 -2.006223606 0.133013626 0.000117986 0.53951348 3.08E-06 Emp1 -1.229643994 -1.941640505 -1.057719863 -1.670167739 0.049829246 8.08E-06 0.568840009 0.000112213 Npm3 -1.400553568 -2.412293425 -1.055999113 -1.818837762 0.046036356 5.58E-05 0.728174615 0.001674663 8430410A17Rik -1.347908078 -1.52613329 -1.055902246 -1.195517406 0.010847714 0.000983831 0.600230442 0.100451603 Tfrc 1.125978247 -2.129730636 -1.054220647 -2.528053125 0.365912218 3.79E-05 0.683758212 4.32E-06 Cox7b -1.077965494 -1.789904885 -1.053832868 -1.749833931 0.552153062 0.00034189 0.676940268 0.000482714 Sdpr -1.117789236 -1.867046081 -1.05242909 -1.757874869 0.209639559 3.87E-06 0.555666523 1.17E-05 Vmn1r32 -1.398768426 -1.565321944 -1.051873097 -1.177121252 0.001097894 8.52E-05 0.545608974 0.065896594 Snord15b -1.458403449 -2.034033433 -1.050921267 -1.465718552 0.005343064 2.45E-05 0.670421556 0.004900771 Pla2g16 -1.180075842 -1.83758344 -1.047480957 -1.63111013 0.232558721 0.000441715 0.731721798 0.002496049 Snora70 -1.29869738 -1.787918642 -1.046573319 -1.440819067 0.039917849 0.000189738 0.69872639 0.006941925 Fam165b -1.159893925 -1.87861901 -1.044727305 -1.69208971 0.157100207 1.93E-05 0.665713257 0.000118139 Cinp -1.215317209 -1.786597253 -1.043996037 -1.534743717 0.032334123 6.08E-06 0.607503266 0.00013573 1810035L17Rik -1.130662254 -1.684185454 -1.043442097 -1.554266091 0.322887322 0.000691751 0.727917448 0.002535506 Bgn -1.524827087 1.308696401 -1.042699039 1.913817549 0.008506322 0.071066767 0.765637001 0.000345655 --- -1.287122238 -1.555669712 -1.042073497 -1.259493566 0.03153509 0.000942617 0.701882187 0.046466246 Snord96a -1.537937067 -2.077867801 -1.041983662 -1.407797722 0.009416502 0.000164118 0.777503854 0.03136946 Ogfrl1 -1.059003581 -1.497309469 -1.041244619 -1.472200336 0.576694703 0.00129636 0.693062947 0.001799755 Fam173b -1.497807052 -1.457621955 -1.039042469 -1.0111657 0.000765212 0.00133666 0.689823885 0.90763453 Mir125b-1 -1.374821981 -1.59084037 -1.037793913 -1.200856893 0.005541615 0.000302761 0.707680129 0.080189805 Sepsecs 1.188698439 -1.331944593 -1.036665405 -1.641332078 0.100724727 0.011427897 0.719540761 0.00019017 Adat2 -1.141652779 -1.570356686 -1.031509323 -1.418853081 0.149501266 0.00014289 0.726115548 0.001281799 Nppb -1.082187905 -2.174511926 -1.03117861 -2.072015567 0.514621315 1.35E-05 0.798701332 2.65E-05 Ssr4 -1.273361068 -1.667931575 -1.026721263 -1.344866635 0.010217934 2.15E-05 0.75036443 0.002716374 Rpain -1.188418642 -1.506293598 -1.0221306 -1.295527287 0.06698025 0.000345503 0.804593926 0.010042515 Vgll3 1.046488726 -1.573321849 -1.019687662 -1.678878596 0.721130181 0.002788593 0.878044337 0.00101145 Tmem208 -1.478348838 -1.855664117 -1.015986869 -1.275294658 0.013512167 0.000543892 0.910178777 0.10032806 Suox 1.47495904 -1.255185417 -1.014315695 -1.877850398 0.023908892 0.160229448 0.927364853 0.001089667 Gm10058 -1.054641631 -1.84670754 -1.009934805 -1.768424615 0.724624314 0.001028434 0.947689254 0.001815051 Clcn6 -1.278714422 -1.714951591 -1.009928096 -1.354468023 0.056632201 0.000461715 0.934558996 0.022573371 Ugp2 1.178266223 -1.43359826 -1.007737825 -1.702230835 0.197913608 0.010299507 0.950225548 0.000647686 Cxcl5 -1.31224798 -1.658301477 -1.006873928 -1.272397098 0.004719189 2.26E-05 0.933587119 0.010021342 Cox7b -1.04888647 -1.740032557 -1.00508797 -1.667373773 0.655812957 0.000122476 0.962061408 0.000257003 Gm10058 -1.051461317 -1.900107855 -1.004596035 -1.815417064 0.717331426 0.000340954 0.97354484 0.000642112 Gm10058 -1.051461317 -1.900107855 -1.004596035 -1.815417064 0.717331426 0.000340954 0.97354484 0.000642112 Gm10058 -1.051461317 -1.900107855 -1.004596035 -1.815417064 0.717331426 0.000340954 0.97354484 0.000642112 Gm10058 -1.051461317 -1.900107855 -1.004596035 -1.815417064 0.717331426 0.000340954 0.97354484 0.000642112 Gm10058 -1.051461317 -1.900107855 -1.004596035 -1.815417064 0.717331426 0.000340954 0.97354484 0.000642112 Gm7241 -1.234081119 -1.69220292 -1.003756926 -1.376376621 0.055160574 0.000133062 0.970735082 0.006783659 Cpa6 1.033217059 -1.895625526 -1.003091938 -1.964648477 0.754129372 2.31E-05 0.976351494 1.30E-05 1500011K16Rik -1.053348033 -1.612944454 -1.002831973 -1.535591483 0.645794418 0.000733199 0.979969316 0.001729696 --- -1.336423339 -2.261091204 -1.001208823 -1.693942627 0.109884715 0.00029319 0.994420927 0.007882947 Kcna4 -1.026601393 1.46676334 1.009250519 1.519710548 0.792849058 0.001634293 0.926530385 0.00081229 Ttbk2 1.120732142 1.519690481 1.011183117 1.371144183 0.151423795 7.32E-05 0.884327429 0.000914985 Zfp438 -1.048881156 1.515310314 1.013761864 1.611253271 0.628624861 0.000753014 0.889387355 0.000228073 Hectd1 1.393639514 1.798899197 1.016988718 1.312721239 0.003667454 2.60E-05 0.861809617 0.012677374 Tnks2 1.442923851 1.963758881 1.022825809 1.392023053 0.001385345 4.07E-06 0.809535434 0.002974847 Ifi203 1.312595299 2.682464222 1.023043513 2.090726382 0.086559668 1.12E-05 0.879377265 0.000204147 Tgtp1 1.419320187 1.715917654 1.025619782 1.239945084 0.005276286 0.00017045 0.814537498 0.06185477 Tpbg 1.273487291 2.170173023 1.026625896 1.749491996 0.043517849 5.71E-06 0.812615987 0.000158589 Erap1 1.481100362 2.379436482 1.027326084 1.650433168 0.005146156 4.16E-06 0.822954755 0.000860655 Tnfaip6 -1.650573454 1.291419425 1.028288632 2.191882177 0.000933429 0.050666476 0.818743239 1.37E-05 Cxcr7 -1.780089711 -1.177939086 1.028322335 1.55399038 0.000836781 0.247483041 0.839819528 0.00592509 Ube2l3 1.000892009 1.538017336 1.029084957 1.581339936 0.991222829 9.85E-05 0.72415774 5.34E-05 Prtg 1.221410247 1.668165748 1.029151499 1.405584474 0.049638199 8.27E-05 0.761761436 0.002627668 Ugdh 1.20440522 1.591953456 1.029525305 1.360801448 0.047825546 9.46E-05 0.739060825 0.002987509 H2afy -1.008600633 2.113303858 1.031036616 2.197633522 0.960344447 0.000603712 0.859225003 0.00039011 Igf2bp1 1.153207306 1.767421708 1.031270331 1.580539387 0.290876232 0.000645799 0.81593993 0.003437087 Sesn3 1.163746111 1.713788308 1.032069433 1.519874919 0.098981744 2.18E-05 0.71822187 0.000254524 Abcd3 1.209542056 1.534551394 1.0327643 1.310272666 0.057916373 0.000388889 0.731197483 0.010963417 Ncam1 -1.101449308 1.316873957 1.034385322 1.500344783 0.317263602 0.010590438 0.722041453 0.000685478 Vcam1 1.03179702 2.111036652 1.035827863 2.119283678 0.711701263 3.91E-07 0.677903159 3.67E-07 Hnrnpul2 1.191780854 1.516127728 1.03603833 1.317999391 0.043726836 0.000126845 0.66104948 0.003665654 Map2k4 1.320082723 1.498362283 1.037555386 1.177679118 0.001542073 5.58E-05 0.609531513 0.036380423 Il13ra2 1.205173261 2.934343122 1.045508352 2.54559269 0.345868167 6.67E-05 0.819365327 0.000253519 Ext1 -1.080420208 1.443098759 1.045896429 1.63071262 0.34804533 0.000427077 0.582060789 2.78E-05 Fbxl17 1.091240621 1.506059658 1.046194901 1.443890472 0.312687045 0.000240694 0.596448258 0.000620952 Tm9sf2 1.383598946 1.494229963 1.047347826 1.131092582 0.003332916 0.000653373 0.621675563 0.200642615 Zbtb1 1.172682499 1.64600118 1.047410299 1.470166553 0.19660691 0.000848576 0.69915753 0.005562029 Lphn2 1.113507952 1.543926509 1.048685032 1.454046753 0.200728373 9.50E-05 0.562010829 0.000372956 Pde4b -1.137759674 1.445703915 1.050610269 1.728110604 0.238914821 0.003514515 0.645043409 0.000138546 Gm5887 -1.080053382 1.437812985 1.051414398 1.632756956 0.474859932 0.003892313 0.639935353 0.00037442 Aak1 1.173269383 1.491094645 1.051951851 1.336913582 0.063830969 0.000191674 0.533405706 0.002635138 Ptplad2 1.264507381 1.903401748 1.052454765 1.58420921 0.041213711 2.62E-05 0.631406059 0.000613691 Hdgfrp3 1.237944412 1.563543873 1.052456567 1.329269715 0.036998227 0.000278584 0.589001928 0.008308992 Acvr1 1.206773365 1.49097541 1.053260126 1.301308925 0.029137826 0.000149652 0.512490062 0.004310009 Adam10 1.538999336 1.907872206 1.054407759 1.307131986 6.76E-05 8.57E-07 0.501119994 0.003679565 AI607873 1.232227921 2.514542613 1.055109303 2.153105979 0.177466695 2.22E-05 0.720539352 0.000137999 Tcf12 -1.006413497 1.457392912 1.056120312 1.549053797 0.939053192 0.00044304 0.517003946 0.000113242 Galnt4 1.172091083 1.527819928 1.065535514 1.388924817 0.149014179 0.001166683 0.551079215 0.00705257 Lrig3 1.210439544 1.749294695 1.065843372 1.540328194 0.02084432 2.62E-06 0.398559113 4.17E-05 Lphn2 -1.155279837 1.505086339 1.066927993 1.85517002 0.26937206 0.005822196 0.613655407 0.00023526 Atxn1 -1.033538663 1.540729667 1.06774732 1.700284761 0.763862598 0.001323937 0.552508902 0.000233997 Tcf4 1.002301437 1.40732957 1.068677893 1.500528627 0.981008587 0.002961803 0.495344539 0.000795758 Kdm4c 1.370848321 1.55210119 1.068901311 1.2102309 0.001473802 8.11E-05 0.417165502 0.031436991 Pdgfra 1.06329771 1.865091264 1.069082413 1.875237999 0.622833358 0.000168659 0.592737973 0.000155584 Plod2 1.577415641 1.501529282 1.071810367 1.020247682 0.000212386 0.000580982 0.461111557 0.82973752 Trp53inp1 1.976338292 3.760327182 1.072218532 2.04008216 3.09E-05 1.40E-08 0.544023728 1.93E-05 1190002N15Rik 1.400886953 1.608426105 1.07246033 1.231343606 0.001182981 5.48E-05 0.412412201 0.02503125 Rcan1 1.186815757 1.639125382 1.072805286 1.481664162 0.136208554 0.000460936 0.526748429 0.00279125 Baz1a 1.366991912 1.527114603 1.073153986 1.198857952 0.00931661 0.001140571 0.506307662 0.101862135 Usp9x 1.348067427 1.72542361 1.075525635 1.376590877 0.0168664 0.000219627 0.518451568 0.011619728 Dock4 1.219461855 1.613683288 1.075636531 1.423362843 0.028641806 4.22E-05 0.384508734 0.00069637 Ppp3ca 1.134163507 1.623645759 1.075939431 1.540293338 0.245556809 0.00037967 0.492434545 0.000996689 Bcor 1.261588415 1.66453234 1.076443704 1.420253496 0.02205484 6.35E-05 0.427319552 0.001670109 Zeb2 1.20859327 1.836007763 1.078174244 1.637884581 0.039917201 4.52E-06 0.3828125 4.11E-05 Ap3b1 1.455802688 1.529886831 1.080934184 1.135941696 0.000308683 9.78E-05 0.338938867 0.12738695 Helb 1.145757097 1.543364085 1.081232234 1.456447447 0.112754344 9.94E-05 0.347608313 0.000371312 Uaca 1.087281159 1.61583889 1.082151087 1.608214947 0.293120567 2.25E-05 0.320178512 2.49E-05 Ppm1l 1.014854362 1.438277191 1.085152547 1.53790555 0.845366217 0.000248095 0.28959146 4.95E-05 S100a2 -1.037874993 1.34900944 1.086292178 1.520921114 0.707991164 0.008311251 0.409101743 0.000745403 Nfia -1.134254409 1.636860713 1.086418064 2.017061684 0.301697463 0.000930708 0.491939647 3.67E-05 Btg2 1.145118752 1.973012275 1.087028977 1.872924978 0.288888575 7.92E-05 0.508185607 0.000169005 Ccl11 1.271566011 1.578388519 1.087103637 1.349416299 0.014853562 0.000122139 0.349901796 0.003831465 Ly75 1.348999464 1.684053141 1.089083557 1.359581404 0.002396299 1.64E-05 0.308345009 0.001982419 Frk 1.410554782 1.588138928 1.090356398 1.227628635 0.0027512 0.000249526 0.375677372 0.048002555 6720456H20Rik 1.095467282 1.796330896 1.09119484 1.789325009 0.306359448 9.13E-06 0.326775962 9.82E-06 Myo1b 1.283962986 1.808061748 1.093996279 1.540552839 0.011686179 8.29E-06 0.314239074 0.000196901 Zadh2 1.217332133 1.589822985 1.096905779 1.43254743 0.049102684 0.000175322 0.327578047 0.001517313 E230016K23Rik 1.214881936 1.546455949 1.097325501 1.396815196 0.098590798 0.00144985 0.412346215 0.008948926 Parp8 1.253504115 1.653586142 1.099003248 1.449773096 0.025029876 7.06E-05 0.311528231 0.00105303 Rc3h1 1.328359205 1.579078423 1.100020892 1.307642728 0.006603612 0.000158883 0.301705822 0.009358278 Crot 1.336253144 1.57885921 1.10232281 1.302457193 0.002872808 5.89E-05 0.244395446 0.005393748 Reck 1.355992635 1.601312202 1.102606623 1.30208483 0.022404501 0.001426813 0.423448905 0.043006307 Zfp365 1.250458256 1.553951812 1.102660626 1.370282829 0.059672728 0.001242456 0.384922756 0.011996949 Tshz1 1.174779382 1.719394511 1.103640569 1.615276506 0.068409609 1.20E-05 0.246452911 4.28E-05 Efna5 1.228504938 1.504493634 1.107017898 1.355714029 0.040485739 0.000533765 0.282986131 0.004928363 Bmper 1.179128441 1.513233745 1.107824588 1.42172599 0.136475317 0.00142822 0.3426494 0.004619218 Stambpl1 1.331001509 1.557134961 1.112636064 1.301669834 0.010866157 0.000467965 0.290774023 0.017019646 Cd47 1.09040169 1.963251865 1.115010962 2.007560491 0.427783271 1.90E-05 0.321765672 1.35E-05 Map3k5 1.05410183 1.718907445 1.116067936 1.819954609 0.605816272 9.49E-05 0.289917906 3.52E-05 2310047M10Rik -1.145878534 1.245590422 1.117295436 1.594710555 0.220753744 0.057913024 0.314104074 0.000636038 Srgap2 1.20850507 1.600654531 1.119745887 1.48309376 0.080245507 0.00036496 0.27867712 0.001561441 Trip12 1.481279795 1.575916555 1.120815792 1.192423043 0.000939547 0.000269686 0.244041231 0.081769426 Tlr7 1.153690843 4.153649155 1.121022586 4.036033177 0.182159091 1.62E-09 0.280720413 2.11E-09 6330578E17Rik 1.472813851 1.493718867 1.121979669 1.137904969 0.000819308 0.000609194 0.226002065 0.177094172 Hipk3 1.29564993 1.799179091 1.12249542 1.558731446 0.025700524 6.21E-05 0.28366205 0.00078595 Prl7a2 1.429671452 1.702629723 1.126478413 1.341549925 0.014697264 0.001015075 0.368748185 0.038190929 Zfp36l1 -1.033697818 1.782695474 1.127309808 2.077370915 0.77108032 0.000149375 0.301742404 1.43E-05 Has2 1.262699048 1.652630002 1.128364928 1.476812498 0.075781884 0.001047163 0.337200057 0.006423204 Rest 1.2536318 1.544323798 1.129518366 1.391430955 0.025706974 0.00029357 0.199648946 0.002677559 Rsbn1 1.227975569 1.677368347 1.130124648 1.543707676 0.1253222 0.001100199 0.347716753 0.003996547 Fbxo11 1.299473549 1.514370311 1.130405677 1.317343319 0.025918488 0.001488348 0.26260317 0.020164599 Arih1 1.468963177 1.498392437 1.131499145 1.154167639 0.000248108 0.00015632 0.138268315 0.089578031 Fam199x 1.185841958 1.506633697 1.133280513 1.43985343 0.059367504 0.000228958 0.154020944 0.000637135 Antxr2 1.439746839 1.945860306 1.133739809 1.532282781 0.002373463 9.70E-06 0.22180676 0.000693775 4930429B21Rik 1.400606012 1.744425607 1.134701317 1.413246849 0.008832382 0.000193151 0.272337021 0.00752511 Camsap1l1 1.293989248 1.624428205 1.13597874 1.426067418 0.00434372 1.76E-05 0.114318463 0.000362895 Irx5 1.174978694 1.504702336 1.136459093 1.455373328 0.0907177 0.000424837 0.171360307 0.00086815 Akr1c18 1.717021076 2.203822963 1.137445871 1.459929271 0.003831026 0.000179415 0.422231894 0.029408777 Dennd4c 1.413148539 1.649092219 1.139219446 1.329427072 0.003288141 0.000161061 0.202604796 0.011307878 Pdcd4 1.453668714 2.015797669 1.140314985 1.581271074 0.016574176 0.000168155 0.354911106 0.004963012 Dclk1 -1.098930216 3.796739731 1.142331711 4.766210013 0.486954933 9.79E-08 0.331020812 1.39E-08 1700081L11Rik 1.253968017 1.51774082 1.142677343 1.383040097 0.028269486 0.000504407 0.170992673 0.003541405 Marcksl1 1.093249618 1.985071456 1.146753499 2.082221297 0.449910909 3.64E-05 0.252483407 1.82E-05 Exoc2 1.337832128 1.684395457 1.14881102 1.446408726 0.020076329 0.000352505 0.231083439 0.005035131 AI314180 1.537037068 1.516883135 1.148893695 1.133829175 0.000621419 0.000804683 0.176864273 0.218928735 Cited2 1.348606282 1.785943553 1.14965403 1.52247341 0.013574131 8.57E-05 0.208527977 0.001425199 Dtx3l 1.353430345 1.613571916 1.150031237 1.371077658 0.002967358 5.96E-05 0.118773883 0.002192785 Zswim7 -1.096603008 1.247815069 1.151043021 1.575038648 0.394873305 0.053839194 0.202058576 0.000726889 Plau -1.002334358 1.788110391 1.152300478 2.065250264 0.986627186 0.000834965 0.317308767 0.000117706 Adora2b 1.119227192 1.717318401 1.152307148 1.768075583 0.239588936 4.17E-05 0.144532697 2.44E-05 Dcaf5 1.016476933 1.411773689 1.153734774 1.602409601 0.881836402 0.006617006 0.20676641 0.000670613 Exoc4 1.258603863 1.637565537 1.154283048 1.501834052 0.016813982 4.69E-05 0.112237526 0.000292507 Reep3 1.547858131 1.614533494 1.155547483 1.205323717 2.65E-05 1.00E-05 0.060834878 0.019737571 A930001N09Rik 1.534170495 1.625512332 1.156113057 1.224946013 0.001031092 0.000355845 0.182293 0.069992021 Cdkn2c -1.69420548 1.131389765 1.15668023 2.21713246 0.000113365 0.232866383 0.163677174 1.45E-06 Cenpj 1.307103305 1.531971697 1.156847559 1.355866603 0.017799117 0.000785699 0.165702483 0.008655971 Nfatc3 1.157447538 1.605606899 1.157001815 1.604988595 0.236798929 0.001348207 0.237973615 0.001356758 Usp8 1.305143947 1.528791502 1.159696954 1.358420924 0.002782037 5.02E-05 0.063064904 0.000960896 D030016E14Rik 1.377282061 1.493514845 1.160741311 1.258699599 0.0012621 0.000183789 0.081308538 0.011746134 Snx24 1.455111245 1.666062841 1.162465557 1.33099148 0.000415696 2.17E-05 0.085189939 0.003467472 Ptp4a1 -1.104153734 1.329074907 1.16669552 1.7121292 0.431386677 0.035765656 0.22815329 0.000632539 Sos2 1.696203734 2.038288288 1.169257721 1.405069609 0.000204375 1.04E-05 0.161180796 0.006290432 Gkap1 1.43370331 1.97868336 1.169318469 1.613800415 0.000996632 1.84E-06 0.092676374 7.96E-05 Maoa 1.808556403 1.644759366 1.169676042 1.063741016 2.25E-05 0.000127419 0.119909052 0.524026521 Lima1 1.112028313 1.570133777 1.169888192 1.651829315 0.299501642 0.000448621 0.133843513 0.00017287 Zyg11b 1.421038509 1.592533486 1.171702363 1.313106743 0.003480444 0.000384731 0.135058787 0.016510448 Ptp4a1 -1.096962288 1.312907873 1.173130431 1.689554676 0.462194418 0.043370461 0.213314715 0.000785042 Lphn2 -1.001444865 1.506424362 1.17382523 1.770833848 0.99153046 0.008509608 0.250454085 0.000797261 Tnc 1.045725325 6.243162414 1.176090278 7.021463905 0.763999128 6.59E-09 0.28563565 2.98E-09 Lpin1 1.100568909 1.500294748 1.176101263 1.6032604 0.36472345 0.001450304 0.135308853 0.000418791 Slain2 1.19903959 1.583881479 1.176177438 1.553681526 0.042792549 6.38E-05 0.066213857 9.68E-05 Mef2d 1.272800759 1.587687727 1.176432199 1.467477884 0.042508933 0.000787701 0.154702369 0.003256588 Slc19a2 1.283510857 1.53282665 1.176473202 1.404997447 0.01572243 0.000349781 0.094900786 0.00220848 Luzp1 1.458069842 1.654222945 1.177787183 1.336234059 0.001471826 0.000122586 0.1081171 0.00891026 Igf2r 1.249037524 1.632452763 1.178337205 1.54004967 0.026228244 8.56E-05 0.087814612 0.000278768 Igf2bp3 1.424173059 1.558008677 1.181151309 1.292149137 0.000176374 1.88E-05 0.031509443 0.002517183 Apcdd1 1.225432011 2.584748985 1.181279586 2.491620249 0.073620841 3.70E-07 0.135218332 5.90E-07 Fas 1.409484204 3.425940542 1.181478863 2.871742958 0.021355994 2.61E-07 0.228002099 1.60E-06 Nfia 1.127553898 1.687660652 1.181654838 1.768635964 0.21627677 6.44E-05 0.093503585 2.71E-05 Kdelc2 1.21337435 1.596679392 1.182714748 1.55633442 0.054493725 0.000176167 0.089990797 0.000293757 Fbxl20 1.432188811 1.815466391 1.183449591 1.500160413 0.002133892 2.28E-05 0.0992615 0.000830566 Klk1b1 1.358202311 1.542258515 1.184053401 1.34450989 0.013036243 0.001277315 0.138465836 0.015675798 Dyrk3 1.64166316 1.433956103 1.185759662 1.03573458 1.32E-05 0.000300966 0.040132766 0.647782057 4933411G11Rik 1.61962508 1.539066235 1.187039933 1.127997524 0.000890586 0.002118192 0.156028299 0.309949362 Enpp3 1.124829061 1.446666165 1.187117902 1.526777146 0.234635825 0.001649579 0.091794036 0.000551567 BC049715 1.109523525 1.396478241 1.187141439 1.494170382 0.252024034 0.001854267 0.068878269 0.000416851 Snrk 1.298186083 1.674997249 1.189343138 1.534561578 0.026611057 0.000244291 0.121673336 0.001181207 Mta3 1.121534219 1.477323028 1.190938904 1.56874524 0.182289562 0.000309529 0.050790107 8.17E-05 Ifnar2 1.387208217 1.561510034 1.19125342 1.340933642 0.002932506 0.000241683 0.074603991 0.006128001 Pros1 1.718306524 2.326016426 1.191566515 1.612985372 1.05E-05 6.06E-08 0.04704821 3.84E-05 Gkap1 1.321312188 1.70834553 1.192129779 1.54132354 0.02482868 0.000275935 0.134852709 0.001620696 Sumo3 1.310618736 3.359210497 1.196538109 3.066813609 0.038270797 8.05E-08 0.151144531 2.08E-07 Chd9 1.527319515 1.542602572 1.196860732 1.208837068 0.001875952 0.001573473 0.126282385 0.108248983 Gm10524 1.04586124 1.500853381 1.202211616 1.725222524 0.621778617 0.000458233 0.057513241 2.80E-05 Map2k6 -1.208617093 1.352614965 1.202542031 1.965907976 0.113891271 0.017783177 0.122958655 3.39E-05 Arid5b 1.179737945 1.622824079 1.204613844 1.65704287 0.078434861 7.42E-05 0.05067437 4.89E-05 BC018507 1.232056872 1.559938469 1.20651613 1.527600688 0.051547975 0.000481981 0.07611807 0.000723674 Ube2h 1.544363416 1.82888821 1.207220973 1.429632548 0.00035039 1.43E-05 0.060824589 0.001736595 Polk 1.562023657 1.714456115 1.209464489 1.327491924 0.001872561 0.000402882 0.124478027 0.029025471 Phf11 1.476801528 1.681683879 1.209742103 1.377574273 0.000547189 3.73E-05 0.046654246 0.002559975 Ube2h 1.592639256 1.860779073 1.212384556 1.416503958 0.000157835 8.55E-06 0.05179207 0.001825332 Ebf1 1.116312055 1.771794803 1.213156902 1.925505583 0.358156262 0.000228986 0.117613426 6.32E-05 Ifngr2 1.28958379 1.660292391 1.214293878 1.563359358 0.053772798 0.000917951 0.130047685 0.002420467 Lamb1-1 1.241963384 1.584627656 1.216788466 1.552506845 0.052720631 0.000519086 0.075913054 0.00075993 Elf1 1.263405238 1.519807499 1.217938087 1.465112999 0.020282801 0.000360905 0.044409398 0.000786048 Plekhb2 1.583958916 1.535197604 1.219673075 1.182126105 0.000749417 0.001317907 0.084243482 0.139577288 Pgm1 1.509860258 1.285469076 1.220003236 1.038689789 9.48E-05 0.005279944 0.020394805 0.624774794 Ssbp2 1.240496042 1.779399944 1.221485282 1.752130413 0.026423228 1.21E-05 0.037091631 1.61E-05 Irf2 1.185463862 1.792919496 1.221870652 1.847981861 0.136784256 9.61E-05 0.084243637 5.87E-05 Nrg1 1.153405657 1.667074382 1.222059942 1.766303823 0.079603259 9.82E-06 0.018901745 3.02E-06 Ankmy2 1.284037144 1.624422581 1.2231912 1.547446984 0.007543895 3.13E-05 0.024715027 8.93E-05 Osbpl8 1.546667776 1.327162945 1.225990627 1.051996657 0.0004359 0.010048803 0.050111427 0.601697043 St5 1.311887407 1.572229284 1.22661413 1.470033666 0.028396684 0.001163786 0.087074184 0.00380714 Rnf216 1.168902817 1.430683262 1.226965638 1.501749483 0.094080846 0.001065411 0.033805832 0.000368241 Cpd 1.198707879 1.799333075 1.229026643 1.844843374 0.155519924 0.000261379 0.109756955 0.000178747 Chd4 1.358631055 1.615240209 1.232772943 1.465610858 0.007102425 0.000228801 0.04920763 0.001530275 Plscr1 1.40566574 1.753051092 1.235897559 1.541327716 0.007854453 0.000164236 0.074066587 0.0015048 Bbs2 1.049352047 1.588542997 1.237625821 1.873557914 0.658103868 0.000701293 0.065469008 4.22E-05 Gtf2i 1.18278054 1.701489501 1.238370308 1.781458187 0.166067632 0.000408483 0.084012633 0.000194624 Rnf217 1.628130094 1.563202454 1.239712335 1.190274274 0.000507494 0.0010428 0.066789115 0.129318213 Efnb2 1.20743842 1.618036977 1.241541627 1.663737237 0.034240097 3.53E-05 0.01756131 1.97E-05 Ap3s1 1.450249118 1.744805319 1.241558093 1.493727621 0.00490167 0.000201376 0.072100456 0.002902911 Spp1 -1.006605731 1.689725475 1.242589586 2.113504904 0.936976692 1.76E-05 0.019030672 3.22E-07 Ccl8 1.360529798 1.802917192 1.245806916 1.650891227 0.030853728 0.000428927 0.10840077 0.00160353 Tap1 1.153895363 1.802459674 1.247967815 1.949406968 0.1943048 6.83E-05 0.053527888 1.92E-05 Ap3s1 1.434019733 1.670365041 1.249346312 1.455255012 0.00472476 0.000303168 0.056880336 0.003604919 Slain2 1.251810952 1.599725215 1.249815011 1.597174544 0.013261312 3.88E-05 0.013795747 4.01E-05 Ubr2 1.543645846 1.522558044 1.249967334 1.232891485 0.000628241 0.000820048 0.040401146 0.052392376 Lmbrd1 1.523475881 1.374084446 1.250085647 1.127502749 0.000231715 0.002327773 0.020543492 0.181640279 Ttc28 1.067423394 1.480452621 1.250851317 1.734856216 0.580266323 0.004369123 0.072812681 0.000307917 Osr1 -1.007088961 1.812337426 1.251128697 2.283541351 0.961623213 0.001071405 0.142877299 5.63E-05 Nr2f1 1.249282146 1.575949949 1.251964235 1.579333361 0.016592501 7.37E-05 0.015764125 7.04E-05 Nrp1 1.154690516 2.040619238 1.252342612 2.213194265 0.128357597 1.50E-06 0.024236265 4.28E-07 Frrs1 1.547146506 1.562502698 1.253798548 1.266243116 0.000732492 0.000607895 0.042150516 0.035057499 Glis3 1.175273838 1.461903757 1.255338814 1.561495261 0.087798196 0.000734212 0.021736434 0.000180818 Glod4 1.081471918 1.50697657 1.25877712 1.754042426 0.421969752 0.000716834 0.02931953 3.92E-05 2810046L04Rik 1.402672411 1.569966943 1.261305905 1.411739876 0.001167002 9.34E-05 0.014407511 0.001004443 Pbx1 -1.034194246 2.010635998 1.261392345 2.622924332 0.78714093 5.71E-05 0.078388096 1.81E-06 Clcn3 1.284981125 1.667297209 1.262315656 1.63788816 0.019617585 0.000102954 0.02814885 0.000144081 AI452195 1.066988907 1.332485104 1.263484035 1.577873627 0.512378415 0.01016468 0.029674175 0.000338981 Cpe 1.552379618 1.493596637 1.264200012 1.216329347 4.50E-05 0.000110735 0.007639925 0.020896348 Phldb2 1.600726123 1.458982328 1.265459895 1.153403819 0.000199291 0.001288808 0.025193684 0.150612439 Tbx18 1.225519843 1.918952798 1.266704426 1.983440754 0.025494513 1.49E-06 0.0115507 8.43E-07 Neo1 1.534441424 1.686525531 1.26671866 1.392267783 5.09E-05 6.29E-06 0.006621527 0.000551282 Gbe1 1.872195377 1.790377738 1.270675057 1.215144723 4.01E-05 8.33E-05 0.040355485 0.087276077 Fabp4 -1.058530228 2.326460972 1.270985129 3.12996517 0.66009415 1.17E-05 0.079359103 3.86E-07 Rcor1 1.380106171 1.574878192 1.272041014 1.451561984 0.004431057 0.000302778 0.023912342 0.001559167 Lipa 1.548519959 1.294429843 1.272375892 1.063597093 4.75E-05 0.004100191 0.006440057 0.425448464 Ppap2b 1.150218283 3.182361268 1.272402463 3.520413797 0.35305575 1.67E-06 0.120666259 6.34E-07 Ap3s1 1.470801403 1.745687384 1.273222975 1.511182461 0.003294201 0.000163949 0.043613337 0.002020477 Osmr 1.585693843 4.358588651 1.273724422 3.501079883 0.000320648 5.57E-10 0.025830073 4.44E-09 St6gal1 1.121249286 1.318221006 1.274328575 1.498191987 0.146750886 0.002387485 0.005848221 9.44E-05 Prrx1 1.094143157 1.879181424 1.274945869 2.189708521 0.34548235 8.78E-06 0.019745325 7.61E-07 --- 1.505889339 2.923402343 1.275242644 2.475644946 0.001278228 5.63E-08 0.031440491 4.31E-07 Kif3a 1.562612652 1.327495047 1.27600059 1.084007902 0.0003131 0.009174115 0.020971954 0.403148903 Ktn1 1.501393044 1.182549197 1.276230797 1.005203607 0.000192765 0.056965057 0.009296356 0.949640586 Dhrs7 1.416457675 1.645830757 1.277188623 1.484009268 0.016059279 0.001572849 0.074764302 0.007813706 Fzd7 1.338051249 1.521507649 1.281229434 1.456895157 0.004392761 0.000245573 0.01192738 0.000635251 Fryl 1.298548676 1.621928865 1.282863566 1.60233766 0.011540833 0.000101521 0.015046302 0.000129361 Mapkapk2 1.366816142 1.559869938 1.285916606 1.467543874 0.009350174 0.00076994 0.029427208 0.002415821 Blcap 1.490841332 1.436688304 1.290137977 1.243275259 9.90E-05 0.000245184 0.004013954 0.010771391 Gngt2 -1.155892841 1.189839148 1.294576184 1.780465001 0.287509437 0.205958957 0.069100999 0.000624947 Plscr1 1.455176374 1.814451247 1.297036099 1.617267026 0.001619284 2.47E-05 0.017084752 0.000201195 Serpinb8 1.567787978 2.608245506 1.299043987 2.161150414 0.002317676 1.68E-06 0.048134551 1.84E-05 Zbtb38 1.479981312 1.822929971 1.303160478 1.60513533 0.002916578 7.94E-05 0.028935461 0.000683728 Hexim1 1.198655362 1.74934769 1.305551337 1.905354356 0.043277418 8.50E-06 0.005646227 1.75E-06 Aplp2 1.701966604 1.941978195 1.306387408 1.49061436 0.00232061 0.00039252 0.08244793 0.014445478 Klhdc1 1.592772116 2.0445357 1.310652 1.682396859 0.012169335 0.00059292 0.116119415 0.006239822 Rhoj 1.301967428 1.99212537 1.313769564 2.010183683 0.041325953 4.34E-05 0.03574844 3.80E-05 Zfp395 1.309943139 1.6700058 1.316798791 1.678745857 0.054129305 0.001364545 0.050207252 0.001260969 Cd34 1.086019892 1.592077269 1.320760464 1.93620092 0.345097396 8.24E-05 0.00542067 1.99E-06 Zmynd8 1.258791715 1.445232909 1.321264465 1.516958575 0.01484676 0.000569556 0.004688333 0.000191237 Elmod2 1.574893644 1.340827729 1.321576111 1.125159088 0.000267265 0.00741725 0.010058608 0.228131409 Fgd1 1.02623908 1.233285418 1.323083913 1.59001945 0.808107334 0.065150095 0.018315201 0.000593527 Gm10441 1.886469217 2.446179438 1.323774979 1.71653537 0.003223531 0.000199539 0.138394011 0.009153348 Apbb2 1.145341815 1.655580149 1.324916608 1.915153718 0.278001115 0.000933209 0.034811345 9.85E-05 Ceacam1 1.457833422 1.791969176 1.325411316 1.629195892 0.008557529 0.000331454 0.03835232 0.001450126 Golga4 1.579769581 1.249025807 1.326613926 1.048871335 0.000537116 0.047057714 0.015185417 0.647070934 Foxc1 1.243627137 1.485404407 1.329472599 1.587939342 0.051105814 0.001729327 0.014645983 0.000492006 Bbx 1.221752243 2.316025776 1.330083964 2.521385789 0.035780777 1.49E-07 0.005230192 4.59E-08 Serpinb6b 1.109463286 3.041620515 1.333087353 3.654691319 0.409946585 3.45E-07 0.034133186 5.41E-08 Rfx7 1.276738915 1.685220242 1.333293037 1.759868355 0.036716964 0.000228964 0.016687325 0.000108829 Cd53 1.383400214 7.624659987 1.333323297 7.348659261 0.050062416 2.72E-09 0.078075229 3.44E-09 Mlkl 1.61037374 1.232716786 1.33424196 1.021342077 1.24E-05 0.011545757 0.001326754 0.773170641 4931406C07Rik 1.26772162 1.429258039 1.33441113 1.504445302 0.008686078 0.000430563 0.002364273 0.000127695 Tmem131 1.495696875 1.307716947 1.33884101 1.170574806 0.000294672 0.006522261 0.003749137 0.081470505 D14Ertd668e 1.095463745 1.326051113 1.340786973 1.623013143 0.287377527 0.004200688 0.003225403 4.34E-05 Ostm1 1.519699771 1.315723862 1.344116644 1.163707711 0.000188036 0.005267844 0.003170815 0.089121006 Pdgfrb -1.335678083 1.877557151 1.344599248 3.372002044 0.252430281 0.021224056 0.242203784 0.000199702 Zmat3 1.461420762 1.7976186 1.347561898 1.657566661 0.004107992 0.000116954 0.01741438 0.000451345 Arfgef2 1.607681914 1.330624846 1.34824602 1.115898386 0.000132491 0.007172264 0.005385248 0.246319644 Impact 1.59613091 1.429424124 1.34881123 1.207935576 7.84E-05 0.000872739 0.003329054 0.042385957 Elf4 1.470490343 1.583947481 1.352296796 1.456634595 0.001959719 0.000476584 0.01001085 0.002353855 Phf21a 1.147097166 1.268349397 1.352616117 1.495592428 0.141934451 0.017524804 0.004170892 0.00045798 Tmem173 1.660204415 2.613085023 1.355511672 2.133512727 0.022996768 0.000272514 0.147417396 0.001918756 Cd80 1.654633778 4.899344388 1.357691606 4.020103325 0.004702749 5.25E-08 0.060464571 2.64E-07 6530418L21Rik 1.120377144 1.424606116 1.360037938 1.729344779 0.295107137 0.004516189 0.01083662 0.000131996 Spata6 1.841169835 1.435814951 1.363677766 1.063448296 5.25E-06 0.000833925 0.00270903 0.481444162 9030617O03Rik 1.561031901 2.003464191 1.363715105 1.750223284 0.002608899 5.68E-05 0.02316748 0.000424935 Pex1 1.141082987 1.632299749 1.365666447 1.953562557 0.194158967 0.000181907 0.006259743 7.78E-06 Foxo3 1.615742542 1.571908485 1.366094586 1.329033317 2.76E-05 5.03E-05 0.001375577 0.002737323 Aven 1.621795489 1.949096689 1.37625323 1.654000539 0.000146455 5.42E-06 0.004195473 0.000100336 Ercc5 1.285300532 1.48475458 1.378421925 1.592326632 0.035832098 0.002629583 0.010212936 0.000747404 Sema5a 1.111762825 1.415783822 1.3843634 1.762929342 0.416701695 0.015928632 0.022473012 0.00054171 Aggf1 1.183176638 1.37673931 1.384979153 1.611555859 0.03831307 0.000688781 0.000590055 1.54E-05 Fam175b 1.095007998 1.379137267 1.385706895 1.745265809 0.405401166 0.008982444 0.008221588 0.000126939 Nfe2l2 1.479407818 2.014552905 1.389877574 1.892636952 0.000110829 1.93E-07 0.00053167 5.85E-07 Mpp1 1.513103798 1.352946049 1.391774266 1.244458904 0.000375145 0.004305826 0.002297455 0.027302954 Jhdm1d 1.928981422 2.57133253 1.393246974 1.85719843 0.000150791 3.57E-06 0.020808235 0.000260271 Ift81 1.305023942 1.440298754 1.397453753 1.542309558 0.008576628 0.000928996 0.00182201 0.000211295 Lphn2 1.124005365 1.846322746 1.397850805 2.296148949 0.482124007 0.002054675 0.057803836 0.000160447 Ggta1 1.0505589 1.199672077 1.398505964 1.597005702 0.545754369 0.038657293 0.000904937 4.34E-05 Ptpn14 1.411737669 1.887962826 1.399367761 1.871420144 0.006458385 4.10E-05 0.007589807 4.72E-05 Serpinb1b 1.818140235 1.607898457 1.399490771 1.237659785 0.000701953 0.003989702 0.028723714 0.143931067 Trp53bp1 1.512773638 1.176063947 1.40078467 1.089001227 0.000407869 0.091475512 0.002130471 0.356557057 Tmem2 1.706536825 1.834375505 1.404891586 1.510133666 0.000112912 3.23E-05 0.004491237 0.001096993 Cyp2j6 1.495240643 1.143679691 1.40625789 1.075618561 0.000357735 0.139368457 0.001404987 0.408824451 Ppp1r10 1.27430421 1.356137022 1.407871772 1.498281977 0.0157749 0.003927096 0.001705553 0.000439572 Gm608 1.327462663 1.549694621 1.410201223 1.646284532 0.019958622 0.001190401 0.006636898 0.000407695 2010011I20Rik 1.522660245 1.749761372 1.410374341 1.620728295 0.002625505 0.000258714 0.009781346 0.000911596 Grb10 1.142038972 1.412273234 1.411640564 1.745669135 0.301591768 0.014681058 0.01478527 0.000520249 Kctd1 1.522099789 1.624715523 1.418138799 1.513745772 0.000560848 0.000155057 0.002395229 0.000626721 Fam120c 1.124662773 1.387130771 1.418331904 1.749334889 0.170378622 0.001286927 0.000759315 8.28E-06 Entpd5 1.607583219 1.901213918 1.420165945 1.679564223 1.59E-05 5.36E-07 0.000305079 6.16E-06 Igfbp7 1.567054513 2.031258811 1.420626385 1.841454676 8.91E-05 6.53E-07 0.000807317 3.60E-06 4833408A19Rik -1.003890755 1.187402826 1.426039501 1.699871484 0.968862409 0.100931575 0.002793032 9.47E-05 Eif2ak2 1.596251937 1.306815143 1.427000954 1.168253214 0.000243945 0.014157647 0.002301398 0.125366008 Cat 1.847111257 1.459506351 1.430502276 1.130320195 5.10E-07 9.55E-05 0.000160203 0.100992186 Olfml3 -1.049134395 1.412485671 1.431406281 2.12118279 0.766489524 0.047087552 0.040241154 0.000327633 Glrx 1.259345757 1.544751497 1.435037927 1.760260813 0.01894183 0.000200673 0.000991523 1.49E-05 Synpo 1.011856127 1.267594026 1.437082108 1.800292202 0.919769706 0.058450113 0.007147149 0.000166276 A830007P12Rik 1.255012505 1.54318963 1.437533657 1.767621457 0.030065298 0.000416771 0.001773662 3.16E-05 Ttll7 1.884124181 1.512065562 1.442932297 1.157995984 0.000234952 0.006340739 0.012978747 0.273252259 Ddx58 1.410272324 1.6352043 1.447798419 1.678715634 0.00101475 3.91E-05 0.000553288 2.29E-05 Ak3 1.549725739 1.365609581 1.44890648 1.276768219 0.00011125 0.002018593 0.0005029 0.010138597 Inpp5d 1.447089089 2.215680159 1.449500866 2.219372902 0.00576392 6.63E-06 0.005599019 6.48E-06 Trib2 1.203078106 1.917851945 1.44976304 2.311097553 0.200673453 0.000336582 0.017483732 3.03E-05 Pvrl1 1.495886746 1.102606868 1.453784049 1.071573286 0.000388699 0.277964373 0.000726117 0.437621093 Prnp 1.606372686 1.258086115 1.454566405 1.139193795 0.000330547 0.037816546 0.0022183 0.213521894 Ifitm3 1.31860417 1.544670729 1.455789208 1.705375295 0.005253076 0.000141313 0.000525153 1.83E-05 Mbnl2 1.377209737 1.618804601 1.459355444 1.715360592 0.002502102 7.65E-05 0.000686203 2.44E-05 Fggy 1.241614539 1.355712075 1.45970455 1.593843358 0.020994692 0.002626167 0.000471813 6.87E-05 Aox1 1.616479723 1.281308816 1.463702342 1.160209243 0.00039009 0.030996943 0.002482562 0.17211772 Gm10639 3.276636458 3.026988622 1.464389972 1.352817695 2.18E-05 4.42E-05 0.063245621 0.132135843 Gsta2 3.344580143 3.049873409 1.468232503 1.338859611 8.91E-06 2.07E-05 0.047516195 0.120896094 Atxn7l1 1.453248611 1.555398783 1.468690441 1.571926033 0.00214582 0.000572435 0.001742634 0.000467971 St7l 1.570663689 1.511535922 1.469137714 1.413831901 0.00076937 0.001557133 0.002643736 0.00542661 Naip2 1.601830203 1.239611076 1.475599591 1.141924777 0.000247215 0.042625968 0.001245021 0.189480485 Wfs1 1.621887209 1.230051534 1.475619169 1.119120745 0.000385104 0.066120467 0.002215492 0.296567486 Tob1 1.616418362 1.450385593 1.475797331 1.324208656 6.96E-05 0.000707968 0.000481787 0.005620273 Atp6v1h 1.784775127 1.552150763 1.481984816 1.288825594 0.00015686 0.001630244 0.003649964 0.040960838 Atl1 1.777106187 1.624856009 1.48311044 1.356047786 0.000371951 0.001497766 0.006444429 0.026777183 Bag3 1.558945589 1.448542753 1.490185911 1.384652561 0.000733898 0.00294116 0.001713673 0.006987194 Col6a3 1.230393 1.104910551 1.49087179 1.338824237 0.044121493 0.304694541 0.000813048 0.007698507 H2-M10.2 1.440534531 1.472487565 1.495123847 1.528287747 0.002452889 0.001588477 0.001176719 0.00076714 Dhx40 1.714328227 1.779251875 1.496750225 1.553433935 1.79E-05 8.81E-06 0.00030196 0.000134574 Pik3r1 1.689328674 2.018187135 1.49708202 1.788516184 1.50E-05 5.69E-07 0.00020115 4.92E-06 4833427G06Rik 2.061611826 3.501908395 1.497715371 2.544058957 0.000972246 4.85E-06 0.035530501 0.000102146 Steap2 1.43361581 1.391264505 1.499272748 1.454981831 0.000191911 0.000417501 6.27E-05 0.000131876 Uros 1.138035121 1.25115337 1.502119087 1.651426502 0.25385068 0.058471042 0.002231667 0.000416779 Myst4 1.604895274 1.401416122 1.502774357 1.312242765 0.000283533 0.004056532 0.001008862 0.015183008 Tcte2 1.772225981 1.488351109 1.505306897 1.264187082 4.17E-05 0.001121362 0.000895337 0.030141773 Acp6 1.330477059 1.382877696 1.505816928 1.565123299 0.012720076 0.005935205 0.001114195 0.000531055 Vwa5a 1.643880627 1.498825884 1.505996503 1.373108547 3.42E-05 0.000247425 0.000222458 0.001863894 Siae 1.660451563 1.537297194 1.507548506 1.395734834 1.69E-05 8.94E-05 0.000139289 0.000864342 Klhdc5 1.578841042 1.833759064 1.507835806 1.751289396 0.000191633 1.13E-05 0.000492308 2.59E-05 Klhl24 2.056374798 1.838355863 1.507856533 1.34799206 1.09E-05 6.23E-05 0.001921209 0.014950253 Plcb4 1.349277036 1.796093318 1.508667453 2.008266249 0.002032858 3.65E-06 0.000140728 4.91E-07 Tmem42 1.304158297 1.22064178 1.51200077 1.415174304 0.006998062 0.032524731 0.000234112 0.001037917 Abcc2 1.41424286 -1.020736496 1.512217044 1.047554172 0.000758262 0.802567247 0.000160651 0.573269899 Ift172 1.43859447 1.200489307 1.514398748 1.26374704 0.00046129 0.038075465 0.00014037 0.010956052 Capn6 1.577581593 3.083810628 1.517447708 2.966262657 0.00098342 7.74E-08 0.001960287 1.19E-07 Slc35f1 2.918198843 2.380772557 1.518127832 1.238543798 2.85E-06 2.77E-05 0.010585921 0.15239701 N4bp2 1.712146813 2.662104906 1.520434532 2.364024042 4.00E-05 4.35E-08 0.000418361 2.11E-07 Gm6644 1.277329363 1.705073693 1.521657888 2.031221476 0.061633503 0.000590113 0.003700707 4.25E-05 Pcbd2 1.285167588 1.436441641 1.524278674 1.70369793 0.020183409 0.002049241 0.000617443 7.32E-05 Ptgs1 1.232255191 2.072817126 1.524878146 2.565047855 0.147216972 0.000107224 0.007933318 7.76E-06 Akr1b3 1.290322646 1.718555785 1.526043109 2.032507312 0.033483721 0.000199163 0.001601358 1.37E-05 Ankrd42 1.587950588 1.228822107 1.526547483 1.181305835 3.18E-05 0.017462744 7.75E-05 0.046831172 Atp6v1e1 1.606637016 1.220083622 1.527113073 1.159692969 0.000278816 0.06232688 0.000739058 0.153436812 Runx2 1.232443095 1.297200583 1.529447175 1.609810445 0.049131442 0.017941119 0.000647225 0.000240247 Sepp1 1.424325273 1.742049207 1.529830544 1.871089516 0.013919001 0.000607486 0.004540578 0.000209836 Epb4.1l5 1.584612312 1.804259517 1.530996683 1.743212087 0.001068308 0.00012186 0.001945279 0.000213247 Gm6644 1.298331731 1.72392417 1.533350361 2.03598178 0.031214433 0.000204222 0.001567964 1.46E-05 Mab21l1 1.391747272 2.297347849 1.535790675 2.535119325 0.017415399 9.51E-06 0.00357695 2.77E-06 1700109F18Rik 1.443788342 1.406478395 1.536233538 1.496534649 0.00254243 0.004260236 0.000760629 0.001260689 Naip1 1.391487362 1.027648624 1.537067177 1.135163001 0.001699865 0.75313717 0.000185508 0.158432099 Gsta1 4.632174355 4.034282589 1.539762427 1.341019632 1.63E-05 4.32E-05 0.090621839 0.236727672 Nsun3 1.265467033 1.902298479 1.539922237 2.314870047 0.011043824 1.52E-06 0.0001033 6.37E-08 Kazald1 1.26298175 1.204956689 1.541185473 1.470378922 0.029610777 0.073447337 0.000526477 0.001344319 Gm6644 1.272522441 1.708092744 1.54152487 2.069171718 0.068269968 0.000637613 0.00326885 3.71E-05 Fat3 1.419917827 -1.047357756 1.542454152 1.037179678 0.003911557 0.654889849 0.00079602 0.723981456 Ube2r2 1.531965713 1.618268211 1.542495081 1.629390745 4.81E-05 1.38E-05 4.10E-05 1.19E-05 Nqo1 1.782401388 1.244877725 1.543029916 1.077694163 8.36E-05 0.056218851 0.001062424 0.488203263 Pigl 1.338987239 1.075654434 1.544480845 1.240734505 0.001821145 0.352568619 5.56E-05 0.013154577 Sntb2 1.448239751 1.865716793 1.546003116 1.991661928 0.000352108 1.72E-06 7.80E-05 5.40E-07 Trim34 1.30358391 -1.068202797 1.547183804 1.111089922 0.013430303 0.4922163 0.000381401 0.279204334 Tmem106a 1.415284066 1.301888701 1.547352157 1.423375235 0.001499149 0.009698485 0.000219185 0.001321752 Irak4 1.743206739 1.389928313 1.548048389 1.234320772 0.000230117 0.01122906 0.001707834 0.082755756 Plin3 1.43852899 1.081578489 1.550744631 1.165949416 0.002341561 0.435687906 0.000530833 0.13869728 Vdr 1.007621616 1.695310929 1.550939898 2.609437232 0.97148409 0.02426431 0.054289585 0.000434141 Stat3 1.656175369 1.951735959 1.553431372 1.830656298 0.001161001 9.79E-05 0.003194064 0.000250458 Dapp1 1.660609012 1.231188102 1.557283866 1.154582056 0.000590232 0.090760353 0.001742211 0.229633939 Idua 1.621334396 1.284019369 1.55998305 1.235432034 0.000240817 0.023717785 0.000500837 0.049844799 2810002N01Rik 1.132915531 1.123969701 1.562594841 1.550256138 0.129566742 0.153664951 5.25E-05 6.28E-05 Cpt2 1.329253468 1.548317515 1.567138225 1.82540623 0.022081154 0.001467039 0.001186345 9.08E-05 Mocos 1.663741455 1.581507406 1.5714631 1.49379011 0.000195742 0.0004965 0.000559294 0.001463359 Tmem116 1.34300336 1.013450936 1.573558915 1.187431695 0.006007679 0.885275404 0.00021093 0.080061269 Snx30 1.624061638 1.213134586 1.574542114 1.176144705 4.65E-05 0.035863232 8.91E-05 0.071459789 Dyrk4 1.192147349 1.213159002 1.578492899 1.60631391 0.061204599 0.042064396 0.000120728 8.42E-05 Fam82a1 1.968861827 1.991896003 1.58031561 1.598804093 3.49E-05 2.93E-05 0.001220412 0.001000012 Mapre3 1.539591578 1.122927882 1.589982096 1.159681082 0.001065031 0.286441437 0.000590421 0.178723507 Prepl 1.437012458 1.122425207 1.592780753 1.244093087 0.001455785 0.227441227 0.000174087 0.031811193 Pcdhb15 1.446428252 1.294296162 1.599423346 1.431199574 0.002458983 0.021876856 0.000355383 0.003028198 2900010M23Rik -1.211092709 -1.593655309 1.602484253 1.217802233 0.1212493 0.001314072 0.001198215 0.111764439 Aig1 1.685818643 1.057926415 1.602772799 1.005811442 0.000255338 0.606907443 0.000619027 0.957568809 Gsta1 5.356945865 4.513612476 1.606617542 1.353690921 9.89E-06 3.07E-05 0.076719792 0.242131251 Ccdc96 1.637421838 1.11689685 1.610978742 1.09885983 0.000696398 0.346390088 0.000916879 0.419929537 Acsl1 1.372758597 1.425078122 1.611237495 1.672646093 0.0122663 0.006279555 0.000710646 0.000373491 Cbr3 1.42783886 1.09040246 1.61171673 1.230825086 0.005258959 0.434663757 0.000587872 0.074365538 Rsph3a 1.488963161 1.328162087 1.613344849 1.439111134 0.001962165 0.016871019 0.000448053 0.003722344 Tmcc1 1.350546029 1.210617042 1.618760466 1.451041997 0.00082723 0.01718941 9.11E-06 0.000124814 Aldh3a2 1.353685481 1.021378932 1.621974407 1.223807533 0.003491268 0.809427178 6.78E-05 0.034452736 Mdm2 1.982469918 1.801780751 1.626199035 1.477981629 6.01E-05 0.000249535 0.001254231 0.005957185 Gipc2 1.549179937 1.212272685 1.627867632 1.273847807 0.001116881 0.093124956 0.000460177 0.039950735 Pld1 1.673686005 1.950660119 1.630564029 1.900401995 0.000173384 1.29E-05 0.000278528 1.96E-05 5133401N09Rik 1.278239383 1.036970234 1.632562284 1.324414281 0.013294512 0.680923506 6.21E-05 0.005926632 Tns1 1.269051505 1.377119195 1.6358107 1.775110235 0.089013643 0.027915039 0.002093901 0.00062286 Chst14 1.234929633 1.293936727 1.639231613 1.717556962 0.055518202 0.023175326 0.000247751 0.000107012 Arfgef2 1.9044369 1.378268406 1.642370761 1.188607367 0.000560982 0.043566883 0.004106569 0.251547262 Chst11 1.777081046 1.753347578 1.64568995 1.623711251 0.000834042 0.001009867 0.002515148 0.003057924 Asah2 1.705326724 1.541669716 1.648058504 1.489897419 6.67E-06 5.93E-05 1.36E-05 0.000131389 Plxna2 1.446814363 1.841289542 1.649713322 2.099509077 0.011314455 0.000281457 0.001470329 4.41E-05 Cd80 1.681792304 2.280369479 1.654050188 2.242753494 0.003020859 5.93E-05 0.003787821 7.25E-05 Rsph3a 1.506654653 1.3437192 1.656839679 1.477662637 0.002617608 0.019558216 0.000507286 0.003683907 Gabarap 1.618643276 -1.004961419 1.664814575 1.023446941 1.95E-05 0.94887322 1.07E-05 0.764335972 Gm15070 1.885369118 1.135237567 1.665613906 1.002916331 0.000383713 0.366926836 0.002208664 0.983218304 Vcan 1.531107364 2.180572073 1.667832086 2.375292651 0.005400519 3.32E-05 0.001472512 1.12E-05 Nynrin 1.491512187 1.744463645 1.668197609 1.951113847 0.003593877 0.000257741 0.000536523 4.48E-05 Dis3l 1.605911463 1.419016452 1.66933007 1.47505444 0.000255505 0.0029366 0.000123515 0.001346 Ugt1a9 1.457114587 1.513966206 1.677182617 1.742620536 0.000556075 0.000237911 2.80E-05 1.33E-05 Tomm34 1.45112961 1.462221766 1.680812829 1.693660639 0.001647493 0.001410584 9.27E-05 8.05E-05 Ttll7 2.409718007 1.584889347 1.685484691 1.108555741 1.51E-08 2.73E-05 7.22E-06 0.190594512 Pla1a 2.53697016 1.824839518 1.685695778 1.212518902 4.17E-05 0.001961907 0.00527206 0.242377505 Hscb 1.281673636 -1.069433952 1.686804447 1.230646494 0.017623832 0.478065978 6.11E-05 0.041027387 Mgst2 1.348607393 1.170768813 1.687232936 1.464740377 0.026182653 0.210592617 0.000685671 0.006828638 Ptgr1 1.539437044 1.298274333 1.693229575 1.427974276 0.000159714 0.007830755 2.23E-05 0.000851119 Akr1b10 1.601815748 1.177318742 1.693576975 1.244762337 0.001540239 0.194424642 0.000628538 0.089065344 Arsb 1.771673907 1.637305204 1.694965998 1.566415038 1.59E-06 8.34E-06 3.96E-06 2.27E-05 Mettl7a1 1.292060081 1.052364855 1.700620951 1.385131966 0.00332462 0.491972458 4.08E-06 0.000516347 Sgtb 1.309934897 1.233516601 1.700724151 1.601508196 0.036395314 0.093495955 0.000466623 0.00125218 Gm5785 1.966330343 1.627624966 1.702260852 1.409042113 0.000117143 0.001911366 0.000965141 0.017702257 Atp6v0d1 1.719647244 1.443093621 1.713779093 1.438169185 0.000911594 0.013115959 0.000959333 0.013815078 Pon3 1.759416418 1.208937654 1.720721705 1.182349579 4.66E-05 0.070555758 6.94E-05 0.105908715 Copz2 1.196613896 -1.010179977 1.721930634 1.424501315 0.116265449 0.926002566 0.000179525 0.005335363 Mmgt2 1.4557034 1.058341538 1.722721007 1.252471622 0.003996486 0.610564397 0.000206479 0.05790992 Gla 2.001086994 1.385929391 1.724938816 1.1946724 5.83E-06 0.004913753 7.16E-05 0.090029862 Prr13 1.816411786 1.256007525 1.730913768 1.196887586 4.58E-05 0.042713154 0.000104562 0.100495689 Plac1 1.163336117 1.384827786 1.731518732 2.061188695 0.320255089 0.043855353 0.002255851 0.000234342 Cblb 1.913233664 1.581804842 1.73645803 1.435651992 2.33E-05 0.000614356 0.000116879 0.003762683 Zcchc2 1.730539425 1.082964165 1.737039945 1.087032163 1.72E-05 0.365993436 1.60E-05 0.344574689 Alox5ap 1.084396908 1.263880676 1.739064797 2.026905808 0.500125638 0.065471814 0.000339565 3.30E-05 Ubc 1.710410457 1.255000173 1.743150894 1.27902321 0.000295571 0.061838065 0.000216087 0.045211399 Irgm2 1.397328596 1.307143385 1.756001118 1.642666765 0.013434124 0.039880067 0.000314197 0.000916089 Ccl9 1.485197109 1.664754123 1.756829143 1.969225863 0.009713899 0.001769578 0.000803217 0.000159564 Naip5 1.566299462 1.156137805 1.769818293 1.306361834 0.000387787 0.154630736 4.00E-05 0.015122976 Il6 2.134525185 3.689394266 1.778175023 3.073465135 0.000208653 6.76E-07 0.002052257 3.79E-06 Csf1r 1.781490227 1.02671319 1.779228534 1.025409725 8.69E-05 0.806149625 8.87E-05 0.815298688 Gpnmb 1.83302921 1.06010782 1.790214236 1.035346355 0.000269962 0.647473795 0.000384017 0.784998544 Tcp11l2 1.850463584 1.175460251 1.791402354 1.137943096 0.000255126 0.220764286 0.000412023 0.32286846 Ccl2 1.53681516 3.331717956 1.795761899 3.893098089 0.005636553 3.13E-07 0.000559768 7.17E-08 Tom1 1.794935728 1.045564803 1.798834794 1.047836042 0.000716687 0.746277728 0.000695025 0.734427602 Tom1 1.817303937 1.046213211 1.810514661 1.042304658 0.0006976 0.747221939 0.000734858 0.76746439 Mpv17 1.064358166 -1.069568436 1.811925678 1.591636922 0.609509922 0.582094409 0.000213284 0.001673433 Hist1h1c 1.818814624 1.320494242 1.82012439 1.321445157 9.17E-05 0.024185348 9.06E-05 0.023881927 Il18 1.468008065 1.966996622 1.821750523 2.440979182 0.032654624 0.000951741 0.002394662 8.06E-05 Sep-09 1.517403082 1.912353718 1.826129282 2.301435368 0.036294253 0.002941325 0.004876123 0.000403884 Mmp19 1.286665759 1.5616299 1.833090713 2.224827425 0.085151643 0.005591015 0.000563588 4.29E-05 Steap3 1.213995391 -1.113177832 1.846577613 1.366425566 0.136973827 0.397502894 0.000207696 0.02370937 Lif 1.517742163 1.925855913 1.859191157 2.35911894 0.010642859 0.000401568 0.000643444 3.10E-05 Dalrd3 1.391792663 1.020365561 1.863194864 1.365964861 0.028109573 0.883200606 0.000417264 0.036616264 BC031353 1.93819309 1.820067387 1.863868382 1.750272495 1.11E-05 3.17E-05 2.12E-05 6.25E-05 Cpeb4 2.417189554 1.564004686 1.87200648 1.211252507 1.11E-06 0.000969928 4.52E-05 0.0955726 Lxn 1.676199376 2.288482865 1.87439005 2.559068791 8.51E-05 5.13E-07 1.15E-05 1.12E-07 Ddit3 1.348110377 -1.181374993 1.878355182 1.179409148 0.005912962 0.091440716 8.59E-06 0.094398246 Rhoq 1.840203312 1.161649083 1.885704129 1.190371987 4.72E-06 0.096964966 3.04E-06 0.057617625 Tmem67 1.8785033 1.370320238 1.887276405 1.376719994 6.10E-05 0.01333275 5.67E-05 0.012280026 Creg1 1.844129454 1.061298362 1.898345915 1.09249999 3.97E-06 0.486087527 2.36E-06 0.305472054 Mmp14 1.437054827 1.140399058 1.911156901 1.516630743 0.019205566 0.353239435 0.000334991 0.008880919 Rnasel 1.852621126 1.961562251 1.915067269 2.027680464 0.000189289 8.18E-05 0.000115914 5.10E-05 AV249152 1.691555906 1.389129141 1.919875672 1.576628496 0.000133089 0.005633403 1.53E-05 0.000485508 Ppbp 1.774836868 1.282008634 1.92827758 1.392842661 0.000124582 0.038738967 3.30E-05 0.00884598 Cndp2 1.801084067 1.403818374 1.92917939 1.50365967 0.000212722 0.012491244 7.49E-05 0.00397136 Dpcd 1.947224452 1.014340121 1.940597491 1.010888032 1.20E-05 0.888976946 1.26E-05 0.915430918 Ly6c2 1.609908426 2.046579445 1.941135059 2.467647879 0.000433928 7.91E-06 1.79E-05 5.70E-07 Abhd4 1.809080149 1.526861607 1.943751842 1.640524364 0.000320611 0.004431456 0.000111949 0.001431289 Plscr2 3.074136721 3.955534234 1.95617869 2.517042174 5.55E-06 5.51E-07 0.000812106 4.39E-05 Slc4a3 1.846766454 1.575039288 1.957513004 1.669490953 0.001576102 0.011668853 0.000767499 0.005601311 Nqo2 1.692647588 1.351409197 1.96684876 1.57033131 0.000191973 0.012230216 1.60E-05 0.000735511 Trp53inp2 1.701223873 1.217663516 1.967032293 1.40791785 0.000150783 0.076313978 1.34E-05 0.005075956 Dmpk 1.393803007 -1.221251204 1.967911026 1.156109732 0.009811427 0.093341508 2.95E-05 0.212131202 Arl8a 2.182491352 1.385248506 1.991923415 1.264293182 0.000572341 0.084578092 0.001559454 0.202683229 Ly6a 1.840077861 1.803803392 2.008169748 1.968581591 0.000383051 0.000510209 0.000112575 0.000148031 Dync2li1 1.816328654 1.614056026 2.008594119 1.784910145 2.92E-06 3.13E-05 4.85E-07 4.07E-06 Nat6 2.064448484 1.146803257 2.010755631 1.116976823 0.000101979 0.326060494 0.000144904 0.424824281 Ogn 1.916947714 1.093466492 2.013530157 1.148559108 6.48E-05 0.451269322 3.12E-05 0.249713629 Tctn2 2.303905427 1.194266161 2.061040262 1.068373126 0.000675745 0.369179589 0.002084399 0.734658724 Tmem53 1.905471065 1.302564199 2.076841352 1.419711504 0.000926941 0.107510578 0.000320411 0.038908757 Ccl7 1.489517423 2.411355162 2.078727229 3.365217188 0.004839843 3.71E-06 2.70E-05 8.57E-08 Pepd 1.089634654 -1.133630437 2.104702585 1.703877349 0.623266739 0.475159176 0.000687057 0.007683484 H2-DMa 1.840341226 1.318032964 2.105301135 1.507794454 0.000288033 0.04705708 4.32E-05 0.006012778 Sgpl1 1.688759889 1.412266425 2.120564841 1.773373792 1.96E-05 0.000954942 3.40E-07 7.57E-06 Wdr19 1.845937541 1.565691883 2.125079337 1.802455063 0.000167106 0.002260648 2.17E-05 0.000240449 Ly6c1 1.731551283 2.968731448 2.140346423 3.669607595 7.37E-05 3.26E-08 2.32E-06 3.45E-09 C1s 1.706442059 1.092703386 2.145373635 1.373768903 0.009582612 0.625739039 0.000771612 0.096008907 BC028528 1.672595032 -1.186858084 2.151061392 1.083585565 0.009429811 0.332591682 0.000532391 0.645295806 Edil3 1.955173323 1.274611837 2.180545367 1.421535832 2.84E-06 0.015988538 4.98E-07 0.001415713 Arsb 1.682253776 1.40508666 2.181948089 1.822451638 0.005719136 0.051030203 0.000245805 0.002125513 Ifi30 1.769337256 -1.028725366 2.277957413 1.251513474 0.002836902 0.85983664 0.000135576 0.176378512 Xdh 2.316842326 1.503366407 2.292618769 1.487648082 3.84E-06 0.003077252 4.42E-06 0.003690827 Mgst1 2.571688741 2.922660261 2.324108629 2.641291625 3.40E-05 8.94E-06 0.00010419 2.55E-05 Fetub 2.275567622 1.121007628 2.431094069 1.197624262 1.10E-05 0.367599784 4.75E-06 0.163861766 Cp 2.240914637 4.333427979 2.504049859 4.842272678 2.08E-05 2.02E-08 5.22E-06 8.07E-09 AA467197 2.825667681 1.151589594 2.508804048 1.022453083 1.02E-07 0.19328812 4.41E-07 0.832766233 Fbxo36 2.178483871 1.088113872 2.798978624 1.398039943 1.30E-05 0.485961473 5.67E-07 0.013279558 Serpinb9e 2.995929979 1.780635933 2.83598077 1.685569856 7.26E-06 0.002621231 1.26E-05 0.005206503 Hmox1 3.534271364 1.465925689 2.944206606 1.221181865 7.25E-05 0.113308765 0.000311998 0.392094605 Txnip 2.914509712 5.007238917 3.028147243 5.202472532 2.28E-06 1.68E-08 1.53E-06 1.25E-08 Hyal1 2.404957679 -1.163392318 3.217802237 1.150073825 1.51E-05 0.280752176 6.12E-07 0.317464621 Ang2 3.908112392 1.779371199 3.486541091 1.587428963 7.34E-08 0.000665278 2.12E-07 0.003579567 Ppargc1a 3.266253315 2.006017971 3.605389624 2.214303572 3.05E-06 0.000592482 1.23E-06 0.000183547 Hist1h2bc 4.086368092 1.934843339 4.72568815 2.237553258 6.66E-07 0.001272091 2.07E-07 0.000236562 Supplementary Table 16. List of UBTF1/2 binding regions overlapping with histone genes in NIH3T3 cells

GeneID chromosome strand gene start gene end distance gene info peak start peak end Hist1h2ai chr13 + 21808290 21808683 242 exon_1 21808223 21808841 Hist1h3h chr13 + 21809496 21809984 321 exon_1 21809317 21810318 Hist1h2bm chr13 + 21813966 21814347 -148 NA 21813093 21814543 Hist1h4j chr13 + 21826964 21827276 200 exon_1 21826621 21827708 Hist1h4k chr13 - 21842062 21842374 170 exon_1 21841699 21842710 Hist1h2bn chr13 + 21845991 21846372 -89 NA 21845213 21846592 Hist1h1b chr13 - 21871751 21872423 449 exon_1 21871339 21872610 Hist1h3i chr13 - 21874783 21875266 228 exon_1 21874499 21875578 Hist1h2an chr13 - 21878694 21879087 -122 NA 21878442 21879976 Hist1h4m chr13 + 21903652 21903964 249 exon_1 21903502 21904301 Hist1h4m chr13 - 21923715 21924027 215 exon_1 21923321 21924303 Hist1h2bn chr13 + 21925626 21929399 23 exon_1 21924886 21926412 Hist1h2ah chr13 - 22127034 22127421 284 exon_1 22126695 22127580 Hist1h2bk chr13 + 22127755 22128136 278 exon_1 22127603 22128463 Hist1h4i chr13 - 22132684 22133221 146 exon_1 22132555 22133596 Hist1h2ag chr13 - 22134345 22134818 -26 NA 22134111 22135578 Hist1h4h chr13 + 23622918 23623388 260 exon_1 23622651 23623705 Hist1h2af chr13 + 23625779 23626172 244 exon_1 23625605 23626441 Hist1h3g chr13 + 23627286 23627778 259 exon_1 23627092 23627999 Hist1h2bh chr13 - 23634840 23635221 187 exon_1 23634625 23635443 Hist1h3f chr13 + 23635833 23637681 672 exon_1 23635981 23637029 Hist1h4f chr13 - 23643200 23643512 161 exon_1 23642868 23643834 Hist1h1d chr13 + 23646902 23649877 313 exon_1 23646710 23647720 Hist1h3e chr13 - 23653823 23654234 217 exon_1 23653452 23654583 Hist1h2ae chr13 - 23662385 23663089 -60 NA 23662275 23664023 Hist1h2bf chr13 - 23665678 23666059 -83 NA 23665390 23666895 Hist1h3d chr13 + 23666339 23668081 1618 exon_1 23667449 23668465 Hist1h4d chr13 + 23673470 23673782 242 exon_1 23673310 23674115 Hist1h4d chr13 + 23673470 23673782 4123 NA 23677182 23678004 Hist1h1e chr13 - 23712497 23714427 198 exon_1 23713787 23714671 Hist1h2bc chr13 + 23776067 23784349 -66 NA 23775152 23776851 Hist1h4c chr13 - 23790006 23790318 215 exon_1 23789650 23790557 Hist1h1c chr13 + 23830675 23832235 278 exon_1 23830453 23831453 Hist1h3c chr13 - 23836910 23837390 263 exon_1 23836746 23837508 Hist1h2bb chr13 + 23838602 23839070 -394 NA 23837857 23838559 Hist1h2bb chr13 + 23838602 23839070 317 exon_1 23838567 23839272 Hist1h2ab chr13 + 23842956 23843462 262 exon_1 23842753 23843684 Hist1h3b chr13 + 23844248 23844659 253 exon_1 23844022 23844981 Hist1h4b chr13 + 23848889 23849201 223 exon_1 23848706 23849518 Hist1h4a chr13 - 23852714 23853026 130 exon_1 23852483 23853309 Hist1h3a chr13 - 23853721 23854255 232 exon_1 23853523 23854523 H2afy chr13 - 56175535 56236876 201 intron_1 56236096 56237255 Hist2h2ac chr3 - 96024377 96024767 420 NA 96023553 96025141 Hist2h3c1 chr3 - 96042038 96043050 -283 NA 96042052 96044614 Hist2h3c1 chr3 + 96049460 96051219 331 exon_1 96048999 96050583 Hist2h3c1 chr3 + 96049460 96051219 1662 exon_1 96050652 96051592 Hist2h4 chr3 - 96066858 96067256 229 exon_1 96066535 96067520 Hist2h2bb chr3 + 96073622 96074115 -324 NA 96072224 96074372 H2afz chr3 + 137527451 137529886 2754 NA 137530205 137531457 Hist4h4 chr6 - 136752588 136752900 184 exon_1 136752180 136753253 H3f3a chr1 - 182732698 182743734 547 intron_1 182742528 182743846 H3f3b chr11 - 115883274 115885818 512 exon_2 115884672 115885941 H2afx chr9 + 44142797 44144156 399 exon_1 44142475 44143917 H1f0 chr15 + 78858641 78860930 416 exon_1 78858489 78859626 Supplementary Table 17. List of UBTF1/2 binding regions overlapping with histone genes in HMEC Gene ID Chr Strand Gene Type peak start peak end Distance to TSS HIST2H2BA chr1 + pseudo 120904423 120905560 -1043 HIST2H2BA chr1 + pseudo 120905691 120906677 150 HIST2H2BF chr1 + protein-coding 149398705 149399282 236 HIST2H2BF chr1 + protein-coding 149399737 149400866 -1072 HIST2H2BF chr1 + protein-coding 149783122 149785629 -447 HIST2H2AA4 chr1 + protein-coding 149814731 149815463 -779 HIST2H2BC chr1 + pseudo 149821567 149822166 474 HIST2H2AC chr1 + protein-coding 149856919 149860646 257 H3F3A chr1 + protein-coding 226221961 226222894 -27981 H3F3A chr1 + protein-coding 226233979 226234550 -16144 H3F3AP4 chr1 + pseudo 226249052 226252488 342 H3F3AP4 chr1 + pseudo 226263221 226263695 13030 H3F3AP4 chr1 + pseudo 226270369 226272172 20842 H3F3AP4 chr1 + pseudo 226285629 226286208 35490 H3F3AP4 chr1 + pseudo 226296593 226299176 47456 H3F3AP4 chr1 + pseudo 226308922 226310854 59460 H3F3AP4 chr1 + pseudo 226311165 226311879 61094 HIST3H2A chr1 + protein-coding 228633431 228633933 11878 HIST3H2BB chr1 + protein-coding 228644518 228647557 229 H2AFY2 chr10 + protein-coding 71811910 71814304 750 H2AFX chr11 + protein-coding 118964591 118966586 589 HIST4H4 chr12 + protein-coding 14921971 14924284 938 H2AFJ chr12 + protein-coding 14927093 14928330 441 H2AFJ chr12 + protein-coding 14928349 14928900 1354 H1FNT chr12 + protein-coding 48690286 48691090 -32075 H3F3B chr17 + protein-coding 73774645 73776197 439 H1F0 chr22 + protein-coding 38172860 38173421 -27974 H1F0 chr22 + protein-coding 38198209 38198947 -2536 H1F0 chr22 + protein-coding 38200437 38202167 188 H1FX chr3 + protein-coding 129062420 129063338 -27759 H1FOO chr3 + protein-coding 129279637 129280594 18058 H2AFZ chr4 + protein-coding 100870202 100871057 883 H2AFY chr5 + protein-coding 134721673 134722937 12623 H2AFY chr5 + protein-coding 134726530 134727366 7980 H2AFY chr5 + protein-coding 134733730 134735497 315 HIST1H1A chr6 + protein-coding 25991755 25993534 25396 HIST1H1A chr6 + protein-coding 26017408 26018355 159 HIST1H3A chr6 + protein-coding 26020532 26021590 343 HIST1H4A chr6 + protein-coding 26021719 26022391 148 HIST1H3B chr6 + protein-coding 26031702 26032685 95 HIST1H2AB chr6 + protein-coding 26033338 26034095 80 HIST1H2BB chr6 + protein-coding 26043436 26043980 177 HIST1H2BB chr6 + protein-coding 26044124 26045234 -794 HIST1H3C chr6 + protein-coding 26045281 26046168 85 HIST1H1C chr6 + protein-coding 26054938 26057021 720 HIST1H4C chr6 + protein-coding 26103851 26105066 282 HIST1H2BC chr6 + protein-coding 26123136 26124306 411 HIST1H2AC chr6 + protein-coding 26124367 26125265 443 HIST1H2AC chr6 + protein-coding 26125288 26126871 1706 HIST1H1E chr6 + protein-coding 26156211 26157799 446 HIST1H2BD chr6 + protein-coding 26157976 26159835 556 HIST1H2BE chr6 + protein-coding 26171956 26173096 -11498 HIST1H2BE chr6 + protein-coding 26183823 26184515 145 HIST1H4D chr6 + protein-coding 26188553 26189546 255 HIST1H3D chr6 + protein-coding 26195439 26196370 3560 HIST1H3D chr6 + protein-coding 26196713 26197681 2267 HIST1H2BF chr6 + protein-coding 26199081 26200365 -64 HIST1H4E chr6 + protein-coding 26204281 26205671 103 HIST1H2BG chr6 + protein-coding 26215201 26216118 1213 HIST1H2BG chr6 + protein-coding 26216129 26217040 288 HIST1H2AE chr6 + protein-coding 26217084 26217858 323 HIST1H3E chr6 + protein-coding 26224282 26224830 -827 HIST1H1D chr6 + protein-coding 26232966 26233514 1976 HIST1H1D chr6 + protein-coding 26233835 26235198 700 HIST1H3F chr6 + protein-coding 26249640 26250981 525 HIST1H2BH chr6 + protein-coding 26251441 26252308 -5 HIST1H3G chr6 + protein-coding 26270908 26271997 160 HIST1H2BI chr6 + protein-coding 26272244 26274029 -68 HIST1H4H chr6 + protein-coding 26285133 26286643 -161 HIST1H4H chr6 + protein-coding 26296175 26296696 -10708 HIST1H4H chr6 + protein-coding 26305413 26306075 -20017 HIST1H4H chr6 + protein-coding 26310126 26310623 -24647 HIST1H4H chr6 + protein-coding 26313057 26313799 -27701 HIST1H4H chr6 + protein-coding 26321872 26323312 -36865 HIST1H2BJ chr6 + protein-coding 27059299 27060287 40782 HIST1H2BJ chr6 + protein-coding 27064264 27065358 35764 HIST1H2BJ chr6 + protein-coding 27094521 27095389 5620 HIST1H2BJ chr6 + protein-coding 27099398 27101958 -103 HIST1H2BK chr6 + protein-coding 27113960 27115558 -122 HIST1H2BL chr6 + protein-coding 27758828 27760472 16059 HIST1H2BL chr6 + protein-coding 27774915 27776645 -71 HIST1H3H chr6 + protein-coding 27777687 27778419 211 HIST1H2AJ chr6 + protein-coding 27781796 27783513 -136 HIST1H4J chr6 + protein-coding 27791363 27793002 279 HIST1H4K chr6 + protein-coding 27798841 27799634 68 HIST1H2AK chr6 + protein-coding 27804640 27805297 1149 HIST1H2BN chr6 + protein-coding 27805309 27808022 225 HIST1H2AL chr6 + protein-coding 27832819 27835580 1092 HIST1H3I chr6 + protein-coding 27839526 27840298 187 HIST1H3J chr6 + protein-coding 27858097 27858981 31 HIST1H2BO chr6 + protein-coding 27860497 27862053 72 H2AFV chr7 + protein-coding 44885377 44885582 2246 H2AFV chr7 + protein-coding 44885939 44886659 1426 H2AFV chr7 + protein-coding 44886811 44888824 -92 Supplementary Table 18. Sequences of short interfering RNA oligonucleotides sirEgfp sense 5’-GCAGCACGACTTCTTCAAG-3’ sirEgfp anti-sense 5’-CTTGAAGAAGTCGTGCTGC-3’ sirUbtf1/2 #1 sense 5’-AAAGTTGCGTTTAAGGATT-3’ sirUbtf1/2 #1 anti-sense 5’-AATCCTTAAACGCAACTTT-3’ sirUbtf1/2 #2 sense * 5’-CCAATAAACGTAAGAACATTT-3’ sirUbtf1/2 #2 anti-sense * 5’-PATGTTCTTACGTTTATTGGTT-3’ sirUbtf1 sense 5’-ACGAAGGAGGTGAAGGACTCC-3’ sirUbtf1 anti-sense 5’-CCTCCTCCACTTCCTGAGGGA-3’

• sirUbtf1/2 #2 was obtained from Dharmacon, ON-TARGETplus Duplex J- 056732-05 sirRrn3 was obtained from Dharmacon, ON-TARGETplus SMARTpool L-051638- 00-0005

Supplementary Table 19. qPCR primer sequences for qChIP experiments

Gene Forward Reverse H2afx TGCTTCAGCTTGGTGCTTAGC CCCGGCAATCAAGTCACTTT H2afz TGGTTTGATATGGCACCGTAAG TCCATAGCCTACTCTTTAGCGATGT Histone ACAACAGCCGCATCAAGCT CGGTGCCCTTGGTTTGC H1 genes * Histone ACCGGCTGCTCCGCAAG TGATGCGCGTCTTCTTGTTGT H2a genes * Histone CGTGACCAAGGCCCAGAAGAA GATGGTCGAGCGCTTGTTGTAATG H2b genes * Hist1h3a TGCGAGCGGTCTGCTTAGTA TCTCCAAGTGCTCACCAGCTT Hisotne GTGATCCGCGACGCCGTCA CGGCCCTGGCGCTTGAGC H4 genes * H3f3a GGCGTCTCGAAATGCAAGA CGGGCTTTGTGGAATGCT H3f3b GCTGGAAGCGCTCGAACA GTGGAGTATCTGCCCGTTCTG Hist1h1a AGCCCGCGGGACCTT CTGCGCTCTTTGGAAGAAGAA Dnmt3a TCTGGGAATATGACTCAGTGGTAGAG TTGGATGCTAGGTACGGAAACC Dut AAAACCGGAGACTCCAGAAAGA CCGGTAGTTGGGAGTCAAACTT Myc GGCTTGTGATAGCCGGAGACT TTTGCCGGCTTTTCTTTCC Smc4 GCTCCGGAAAGCCGTTCT AGAACCGTTAGAGCAAACTGCAT Asf1a CCAGTTCGAGATCACCTTCGA GCCACTCGCTCACCTTCAG Smarca5 CCCTCGCCTTCCTCAAAGTT TCGCTCAATTTCTCCCGATT Major GACGACTTGAAAATGACGAA CATATTCCAGGTCCTTCAGTG Satellite repeats ENH- AGGAGGCCGGGCAAGCA CCTCCTTGTTAGAGACCGTCCTTAA rDNA ETS- GGTTCGCGTGGTCCTTGT CGACTCTGGGAACATGGTCAA rDNA IGS- ACTTGCAAACCGGGCCACTAAA TTCCTTGTTCTGTCACTCGGTTGC rDNA Psmd3 ATCGTGCACCTCGGCTGTTG TAGTCCGGGGACCGAAGCAG Snrpb2 CCCTCCTCTGCCTCCACAGC AGAGGGCGGCCAAACTCCTC MACS- TCTCCACCCCATCCGTCTGC CGGCCACATCCACCGACTCT 3519 MACS- TGCACGTCAGGACCGCTACG GGATCCCGAGGCCTCTCCAG 3268 MACS- TCGGTCGTCCGACCTGGGTA CGTTTCGGCCCCAAGACCTC 6438

* Primers recognize multiple canonical histone genes. Histone H1 genes (Hist1h1a, Hist1h1c, Hist1h1d, Hist1h1e). Histone H2a genes (Hist1h2ab, Hist1h2ac, Hist1h2ad, Hist1h2ae, Hist1h2af, Hist1h2ag, Hist1h2ah, Hist1h2ai, Hist1h2ak, Hist1h2an, Hist1h2ao. Hist1h2ap). Histone H2b genes ((Hist1h2bc, Hist1h2be, Hist1h2bf, Hist1h2bg, Hist1h2bh, Hist1h2bj, Hist1h2bk, Hist1h2bl, Hist1h2bm, Hist1h2bn, Hist1h2bq, Hist1h2br). Histone H4 genes (Hist1h4a, Hist1h4b, Hist1h4c, Hist1h4f, Hist1h4h, Hist1h4i, Hist1h4j, Hist1h4k, Hist1hm, Hist1h4n, Hist4h4).

Supplementary Table 20. qPCR primer sequences for reverse transcription-RT-PCR

Gene Forward Reverse 45S- 5’ETS ACACGCTGTCCTTTCCCTATT AGTAAAAAGAATAGGCTGGACA AACACTAAA AGCAAAAC Ubtf1/2 CGCGCAGCATACAAAGAAT GTTTGGGCCTCGGAGCTT ACA Rrn3 ATTTTGAGCGCATTGTGTTG GGGAGCATCTGGCGACTGTTC AGC Gapdh GTATGACTCCACTCACGGCA GGTCTCGCTCCTGGAAGATG AA B2m TTCACCCCCACTGAGACTGA GTCTTGGGCTCGGCCATA T H2afx AAGGCCAAGTCGCGCTCTT TCGGCGTAGTGGCCTTTC H2afz TGGCGGTAAGGCTGGAAA CGGGAAACCGCCTTTGT Histone H1 CCGCGGGGTACGATGTGG AGCCGCCTTCTTGTTGAGTTTGA mRNAs* Histone H2a ACCGGCTGCTCCGCAAG TGATGCGCGTCTTCTTGTTGT mRNAs* Histone H2b CGTGACCAAGGCCCAGAAG GATGGTCGAGCGCTTGTTGTAAT mRNA* AA G Hist1h3a TGCGAGCGGTCTGCTTAGTA TCTCCAAGTGCTCACCAGCTT Histone H4 ATGGCGGGCTTGGTGAT GCGCCACCGTAAGGTTCTC mRNAs* H3f3a GGGGTCAAAGGTACCTAAGT CAAATGCTGGCATTGTCC

* Primers recognize multiple canonical histone mRNAs. Histone H1 mRNAs (Hist1h1c, Hist1h1d, Hist1h1e). Histone H2a mRNAs (Hist1h2ab, Hist1h2ac, Hist1h2ad, Hist1h2ae, Hist1h2af, Hist1h2ag, Hist1h2ah, Hist1h2ai, Hist1h2ak, Hist1h2an, Hist1h2ao. Hist1h2ap). Histone H2b mRNAs ((Hist1h2bc, Hist1h2be, Hist1h2bf, Hist1h2bg, Hist1h2bh, Hist1h2bj, Hist1h2bk, Hist1h2bl, Hist1h2bm, Hist1h2bn, Hist1h2bq, Hist1h2br). Histone H4 mRNAs (Hist1h4a, Hist1h4c, Hist1h4f).

Supplementary Table 21. Sequences of primers used in CHART-PCR

Primers Forward Reverse Hist1h2ad AAGGGCACCTTTGATTGGTTT GCACGTTGATTGGGCAAGA -P1 Hist1h2ad CCGAATGCTTCTCATTGGTCTAG TGGGCGCGAAAAAGGA -P2 Hist1h2ad CAGCGAATAATATAAAGGCTACGT GCCGCGTCCAGACATTGTA -A TCT Hist1h2ad ACCGGCTGCTCCGCAAG TGATGCGCGTCTTCTTGTTGT -B Hist1h2ad TCGCGCCAAGGCCAAGAC CCCACGCGCTCCGAGTAGTT -C

Supplementary Methods

Antibodies

Anti-H3K9Me3 (ab8898), anti-H3K4Me3 (ab8580), anti-H3K27Me3 (ab6002) anti-Histone

H4 (ab7311), anti- RNA Pol II [4H8] (ab5408), anti-Pol II phospho Ser5 (ab5131) and anti-

Pol II phospho Ser2 (ab5095) antibodies were obtained from Abcam. Anti-hyperacetylated

H4 (06-946), anti-acetyl H3K9 (07-352), anti-Histone H3 (07-690), anti-H2A (07-146) and anti-H1 (AE-4, 05-457) antibodies were from Upstate (Millipore). Antibodies to α-tubulin

(C-4585) and anti-FLAG M2-affinity gel (A2220) were obtained from Sigma. In-house rabbit anti- Pol I (POLR1A), UBTF1/2 and rabbi sera (RS) were used for western and ChIP assays.

FISH

Following performing immunofluorescence, slides were fixed in methanol:acetic acid (3:1) for 5 min at room temperature then dried dehydrated through 70%-80% ethanol series. Slides were denatured in 70% formamide/2XSSC for 10 min at 83°C and then dehydrated through ethanol series and air-dried. Probes derived from either the intergenic spacer of the human ribosomal gene repeat (kindly provided by Prof. Brain McStay, NUI Galway) or a BAC clone containing the entire mouse rDNA unit (RP23-225M6). 100 ηg of denatured biotin-labeled probe were combined with 30µg salmon sperm DNA and 18µg Cot1 carrier DNA (Invitrogen) in (50% formamide, 20% dextran sulphate in 2XSSC) were added per slide to hybridize at 37°C for 24h in a humidified chamber for 1 hr. Slides were washed in 50% formamide/2XSSC at 42°C for 15 min and 0.1XSSC at 60°C for 15 min. Streptavidin-Alexa fluor 488 was added for 1hr at 37°C and slides were then washed in 0.05% Tween-20/4XSSC for 15 min. Slides were mounted in DAPI. Images were acquired on an Olympus BX-51 microscope equipped with a Spot RT camera (model 25.4), using the UPlanAPO 40X, NA 1.2 water immersion objective and the Spot Advanced software, version 4.6.4.3. Settings for adjusting the image after acquisition (i.e. gamma adjust and background subtract settings) were identical for all images.