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New Rules Pertaining to the Banning of Anabolic Steroids in the Western Australian Harness Racing Industry to Be Introduced 1St September 2014
NEW RULES PERTAINING TO THE BANNING OF ANABOLIC STEROIDS IN THE WESTERN AUSTRALIAN HARNESS RACING INDUSTRY TO BE INTRODUCED 1ST SEPTEMBER 2014 Notice is hereby given that the Board of Racing and Wagering WA have resolved that the RWWA Rules of Harness Racing 2004 be amended. In accordance with section 45 (1) (b) of the Racing and Wagering Western Australia Act 2003 the Board of Racing and Wagering WA on the 10th April 2014 resolved that these amendments be adopted accordingly into the RWWA Rules of Harness Racing. The Harness Racing Board had advised of these amendments and the RWWA Board has determined that these amendments will come into effect on 1st September 2014. The details of the relevant rules pertaining to this ban of anabolic steroids for reference can be found following this advice. There are many implications arising from the introduction of these rules, and to assist trainers and veterinarians to comply with the new rules the following explanatory statement has been prepared. Which steroids are banned under these rules? The new rules ban the use of "anabolic androgenic steroids" in Standardbred horses at any time from birth until retirement. "Anabolic androgenic steroids" include those that are currently registered in Australia by the APVMA for use in horses, such as boldenone, ethylestrenol (in Nitrotain), methandriol, nandrolone, stanozolol and testosterone. Exogenous anabolic androgenic steroids that are banned also include but are not limited to those listed in the WADA prohibited list, such as 1-androstenediol; 1-androstenedione; -
Ranvet's Filybol
Ranvet's Filybol Ranvet Chemwatch Hazard Alert Code: 2 Chemwatch: 4787-83 Issue Date: 08/02/2016 Version No: 5.1.1.1 Print Date: 10/28/2016 Safety Data Sheet according to WHS and ADG requirements S.GHS.AUS.EN SECTION 1 IDENTIFICATION OF THE SUBSTANCE / MIXTURE AND OF THE COMPANY / UNDERTAKING Product Identifier Product name Ranvet's Filybol Chemical Name peanut oil Synonyms Not Available Other means of Not Available identification Relevant identified uses of the substance or mixture and uses advised against Relevant identified Non-virilising anabolic combination for fillies, mares, colts and stallions. uses Details of the supplier of the safety data sheet Registered company Ranvet name Address 10-12 Green Street Banksmeadow NSW 2019 Australia Telephone +61 2 9666 1744 Fax +61 2 9666 1755 Website https://www.ranvet.com.au/other_msds.htm Email [email protected] Emergency telephone number Association / Not Available Organisation Emergency telephone +61 425 061 584 numbers Other emergency Not Available telephone numbers SECTION 2 HAZARDS IDENTIFICATION Classification of the substance or mixture Poisons Schedule S4 Carcinogenicity Category 2, Reproductive Toxicity Category 2, Acute Aquatic Hazard Category 2, Chronic Aquatic Hazard Classification [1] Category 2 1. Classified by Chemwatch; 2. Classification drawn from HSIS ; 3. Classification drawn from EC Directive 1272/2008 - Annex Legend: VI Label elements GHS label elements SIGNAL WORD WARNING Continued... Chemwatch: 4787-83 Page 2 of 10 Issue Date: 08/02/2016 Version No: 5.1.1.1 Ranvet's Filybol Print Date: 10/28/2016 Hazard statement(s) H351 Suspected of causing cancer. H361 Suspected of damaging fertility or the unborn child. -
Part I Biopharmaceuticals
1 Part I Biopharmaceuticals Translational Medicine: Molecular Pharmacology and Drug Discovery First Edition. Edited by Robert A. Meyers. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA. Published 2018 by Wiley-VCH Verlag GmbH & Co. KGaA. 3 1 Analogs and Antagonists of Male Sex Hormones Robert W. Brueggemeier The Ohio State University, Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Columbus, Ohio 43210, USA 1Introduction6 2 Historical 6 3 Endogenous Male Sex Hormones 7 3.1 Occurrence and Physiological Roles 7 3.2 Biosynthesis 8 3.3 Absorption and Distribution 12 3.4 Metabolism 13 3.4.1 Reductive Metabolism 14 3.4.2 Oxidative Metabolism 17 3.5 Mechanism of Action 19 4 Synthetic Androgens 24 4.1 Current Drugs on the Market 24 4.2 Therapeutic Uses and Bioassays 25 4.3 Structure–Activity Relationships for Steroidal Androgens 26 4.3.1 Early Modifications 26 4.3.2 Methylated Derivatives 26 4.3.3 Ester Derivatives 27 4.3.4 Halo Derivatives 27 4.3.5 Other Androgen Derivatives 28 4.3.6 Summary of Structure–Activity Relationships of Steroidal Androgens 28 4.4 Nonsteroidal Androgens, Selective Androgen Receptor Modulators (SARMs) 30 4.5 Absorption, Distribution, and Metabolism 31 4.6 Toxicities 32 Translational Medicine: Molecular Pharmacology and Drug Discovery First Edition. Edited by Robert A. Meyers. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA. Published 2018 by Wiley-VCH Verlag GmbH & Co. KGaA. 4 Analogs and Antagonists of Male Sex Hormones 5 Anabolic Agents 32 5.1 Current Drugs on the Market 32 5.2 Therapeutic Uses and Bioassays -
Permanent Ban on Anabolic Androgenic Steroids From
Permanent Ban on Anabolic Androgenic Steroids to be introduced into the Greyhounds Australasia Rules Warning to trainers – Anabolic Androgenic Steroids (AAS) usage in greyhounds On 1 January 2016, Greyhounds Australasia will introduce Anabolic Androgenic Steroids to the list of Permanently Banned Prohibited Substances within GAR 79A (2) xx. as follows: “Anabolic androgenic steroids excluding those that are defined as an exempted substance pursuant to GAR 1.” The relevant exempted substance listed within GAR 1 is as follows: “Ethyloestrenol when administered orally to a greyhound bitch and where it has been prescribed by a veterinary surgeon for the sole purpose of regulating or preventing oestrus in that bitch.” Participants are advised that in accordance with GAR 79A they must never possess, acquire, attempt to acquire, administer or allow to be administered to any greyhound from birth until retirement, any anabolic androgenic steroid, excluding ethyloestrenol where it is appropriately prescribed for use as an oestrous suppressant in females. “Anabolic androgenic steroids” include those that are currently registered in Australia by the APVMA such as boldenone, ethyloestrenol, methandriol, nandrolone, stanozolol and testosterone. Others include but are not limited to 1- androstenediol; 1-androstenedione; bolandiol; bolasterone; boldione; calusterone; clostebol; danazol; dehydrochlormethyltestosterone; desoxymethyltestosterone; drostanolone; fluoxymesterone; formebolone; furazabol; gestrinone; 4-hydroxytestosterone; mestanolone; mesterolone; -
2004 Prohibited List
The World Anti-Doping Code THE 2004 PROHIBITED LIST INTERNATIONAL STANDARD (update 17 March 2004) This List shall come into effect on 26 March 2004. THE 2004 PROHIBITED LIST WORLD ANTI-DOPING CODE Valid 26 March 2004 (Updated 17 March 2004) SUBSTANCES AND METHODS PROHIBITED IN-COMPETITION PROHIBITED SUBSTANCES S1. STIMULANTS The following stimulants are prohibited, including both their optical (D- and L-) isomers where relevant: Adrafinil, amfepramone, amiphenazole, amphetamine, amphetaminil, benzphetamine, bromantan, carphedon, cathine*, clobenzorex, cocaine, dimethylamphetamine, ephedrine**, etilamphetamine, etilefrine, fencamfamin, fenetylline, fenfluramine, fenproporex, furfenorex, mefenorex, mephentermine, mesocarb, methamphetamine, methylamphetamine, methylenedioxyamphetamine, methylenedioxymethamphetamine, methylephedrine**, methylphenidate, modafinil, nikethamide, norfenfluramine, parahydroxyamphetamine, pemoline, phendimetrazine, phenmetrazine, phentermine, prolintane, selegiline, strychnine, and other substances with similar chemical structure or similar pharmacological effect(s)***. * Cathine is prohibited when its concentration in urine is greater than 5 micrograms per millilitre. ** Each of ephedrine and methylephedrine is prohibited when its concentration in urine is greater than 10 micrograms per millilitre. *** The substances included in the 2004 Monitoring Program are not considered as Prohibited Substances. The Prohibited List 2004 1 26 March 2004 S2. NARCOTICS The following narcotics are prohibited: buprenorphine, dextromoramide, -
Gas Chromatography for the Analysis of Drugs Michelle L
Seton Hall University eRepository @ Seton Hall Seton Hall University Dissertations and Theses Seton Hall University Dissertations and Theses (ETDs) Spring 5-16-2015 QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) Extraction – Gas Chromatography for the Analysis of Drugs Michelle L. Schmidt [email protected] Follow this and additional works at: https://scholarship.shu.edu/dissertations Part of the Analytical Chemistry Commons, and the Medicinal-Pharmaceutical Chemistry Commons Recommended Citation Schmidt, Michelle L., "QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) Extraction – Gas Chromatography for the Analysis of Drugs" (2015). Seton Hall University Dissertations and Theses (ETDs). 2060. https://scholarship.shu.edu/dissertations/2060 QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) Extraction – Gas Chromatography for the Analysis of Drugs BY Michelle L. Schmidt DISSERTATION Submitted to the Department of Chemistry and Biochemistry at Seton Hall University in partial fulfillment of the requirements for the degree of Doctor of Philosophy. May, 2015 1 © Michelle L. Schmidt 2015 2 We certify that we have read this dissertation and that in our opinion it is adequate to scientific scope and quality as a dissertation for the degree of Doctor of Philosophy. APPROVED _________________________________________________________ Nicholas H. Snow, Ph.D Research Mentor and Chair, Department of Chemistry and Biochemistry _________________________________________________________ Yuri V. Kazakevich, Ph.D Member of the Dissertation Committee _________________________________________________________ Sergiu M. Gorun, Ph.D Member of the Dissertation Committee 3 ACKNOWLEDGEMENTS I would like to thank Dr. Nicholas H. Snow for his continued guidance, input, and advice throughout my time at Seton Hall University and whose help was invaluable and deeply appreciated. -
Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DIX to the HTSUS—Continued
20558 Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DEPARMENT OF THE TREASURY Services, U.S. Customs Service, 1301 TABLE 1.ÐPHARMACEUTICAL APPEN- Constitution Avenue NW, Washington, DIX TO THE HTSUSÐContinued Customs Service D.C. 20229 at (202) 927±1060. CAS No. Pharmaceutical [T.D. 95±33] Dated: April 14, 1995. 52±78±8 ..................... NORETHANDROLONE. A. W. Tennant, 52±86±8 ..................... HALOPERIDOL. Pharmaceutical Tables 1 and 3 of the Director, Office of Laboratories and Scientific 52±88±0 ..................... ATROPINE METHONITRATE. HTSUS 52±90±4 ..................... CYSTEINE. Services. 53±03±2 ..................... PREDNISONE. 53±06±5 ..................... CORTISONE. AGENCY: Customs Service, Department TABLE 1.ÐPHARMACEUTICAL 53±10±1 ..................... HYDROXYDIONE SODIUM SUCCI- of the Treasury. NATE. APPENDIX TO THE HTSUS 53±16±7 ..................... ESTRONE. ACTION: Listing of the products found in 53±18±9 ..................... BIETASERPINE. Table 1 and Table 3 of the CAS No. Pharmaceutical 53±19±0 ..................... MITOTANE. 53±31±6 ..................... MEDIBAZINE. Pharmaceutical Appendix to the N/A ............................. ACTAGARDIN. 53±33±8 ..................... PARAMETHASONE. Harmonized Tariff Schedule of the N/A ............................. ARDACIN. 53±34±9 ..................... FLUPREDNISOLONE. N/A ............................. BICIROMAB. 53±39±4 ..................... OXANDROLONE. United States of America in Chemical N/A ............................. CELUCLORAL. 53±43±0 -
Pharmacy Data Management Drug Exception List
Pharmacy Data Management Drug Exception List Patch PSS*1*127 updated the following drugs with the listed NCPDP Multiplier and NCPDP Dispense Unit. These two fields were added as part of this patch to the DRUG file (#50). Please refer to the Release notes for ePharmacy/ECME Enhancements for Pharmacy Release Notes (BPS_1_5_EPHARMACY_RN_0907.PDF) on the VistA Documentation Library (VDL). The IEN column reflects the IEN for the VA PRODUCT file (#50.68). The ePharmacy Change Control Board provided the following list of drugs with the specified NCPDP Multiplier and NCPDP Dispense Unit values. This listing was used to update the DRUG file (#50) with a post install routine in the PSS*1*127 patch. NCPDP File 50.68 NCPDP Dispense IEN Product Name Multiplier Unit 2 ATROPINE SO4 0.4MG/ML INJ 1.00 ML 3 ATROPINE SO4 1% OINT,OPH 3.50 GM 6 ATROPINE SO4 1% SOLN,OPH 1.00 ML 7 ATROPINE SO4 0.5% OINT,OPH 3.50 GM 8 ATROPINE SO4 0.5% SOLN,OPH 1.00 ML 9 ATROPINE SO4 3% SOLN,OPH 1.00 ML 10 ATROPINE SO4 2% SOLN,OPH 1.00 ML 11 ATROPINE SO4 0.1MG/ML INJ 1.00 ML 12 ATROPINE SO4 0.05MG/ML INJ 1.00 ML 13 ATROPINE SO4 0.4MG/0.5ML INJ 1.00 ML 14 ATROPINE SO4 0.5MG/ML INJ 1.00 ML 15 ATROPINE SO4 1MG/ML INJ 1.00 ML 16 ATROPINE SO4 2MG/ML INJ 1.00 ML 18 ATROPINE SO4 2MG/0.7ML INJ 0.70 ML 21 ATROPINE SO4 0.3MG/ML INJ 1.00 ML 22 ATROPINE SO4 0.8MG/ML INJ 1.00 ML 23 ATROPINE SO4 0.1MG/ML INJ,SYRINGE,5ML 5.00 ML 24 ATROPINE SO4 0.1MG/ML INJ,SYRINGE,10ML 10.00 ML 25 ATROPINE SO4 1MG/ML INJ,AMP,1ML 1.00 ML 26 ATROPINE SO4 0.2MG/0.5ML INJ,AMP,0.5ML 0.50 ML 30 CODEINE PO4 30MG/ML -
Anabolic Steroid Use, Misuse and Addiction
Anabolic Steroid Use, Misuse And Addiction Introduction Anabolic steroids have an important role to play in the treatment of medical conditions. There is, however, an illicit use of anabolic steroids. Today, most athletes, involved in sports activities that require greater strength, take anabolic steroids to increase their weight and strength. These sports include competitive sports like weight lifting, wrestling, and other strength based contests. In addition, people who are obsessed about having a “perfect” physical appearance also misuse anabolic steroids. The number of individuals using anabolic steroids for sports or to improve their looks is growing. This increased use of anabolic steroids is driven by the perception that they may give a person an edge when it comes to sports activities. Unfortunately, many individuals use anabolic steroids without regard for the disastrous impacts it can have on their bodies. Anabolic Steroids And Testosterone: An Overview Anabolic steroids are an androgenic hormone, and is also known by its proper name anabolic-androgen steroids (AAS). Testosterone is a natural anabolic steroid and it is the primary sex hormone in males. In order to understand anabolic steroids, it is important to know how testosterone works. Testosterone is vital for the development of reproductive organs like the prostate and testes. It enhances male sexual features such as increased bone mass, muscles and body hair growth.1 Testosterone also promotes health and overall wellbeing. For example, it helps ce4less.com ce4less.com ce4less.com ce4less.com ce4less.com 1 prevent osteoporosis. Many abnormalities in the body, such as bone loss or frailty, are associated with testosterone deficiency.2 Synthetic anabolic steroids are an artificial form of the male hormone testosterone. -
Anti-Doping Manual Revised Dec. 2018
PGA TOUR Anti-Doping Program Manual REVISED DECEMBER 2018 Table of Contents How To Use This Manual .......................................................................................................................................................2 SECTION 1: Player Guide To Anti-Doping ...........................................................................................................................3 Who is covered by the Anti-Doping Program .........................................................................................................3 What substances and methods are banned ..........................................................................................................3 Am I liable for a prohibited substance in my body even if I did not intend to take the substance ........................3 What should players know about nutritional and health products ...................................................................3 Are there supplements that have been tested/certified as free from banned substances ........................3 What about medical treatment.................................................................................................................................4 What medications are permitted .............................................................................................................................4 Who conducts the testing and who will be tested ................................................................................................4 What are the steps in -
2019 Prohibited List
THE WORLD ANTI-DOPING CODE INTERNATIONAL STANDARD PROHIBITED LIST JANUARY 2019 The official text of the Prohibited List shall be maintained by WADA and shall be published in English and French. In the event of any conflict between the English and French versions, the English version shall prevail. This List shall come into effect on 1 January 2019 SUBSTANCES & METHODS PROHIBITED AT ALL TIMES (IN- AND OUT-OF-COMPETITION) IN ACCORDANCE WITH ARTICLE 4.2.2 OF THE WORLD ANTI-DOPING CODE, ALL PROHIBITED SUBSTANCES SHALL BE CONSIDERED AS “SPECIFIED SUBSTANCES” EXCEPT SUBSTANCES IN CLASSES S1, S2, S4.4, S4.5, S6.A, AND PROHIBITED METHODS M1, M2 AND M3. PROHIBITED SUBSTANCES NON-APPROVED SUBSTANCES Mestanolone; S0 Mesterolone; Any pharmacological substance which is not Metandienone (17β-hydroxy-17α-methylandrosta-1,4-dien- addressed by any of the subsequent sections of the 3-one); List and with no current approval by any governmental Metenolone; regulatory health authority for human therapeutic use Methandriol; (e.g. drugs under pre-clinical or clinical development Methasterone (17β-hydroxy-2α,17α-dimethyl-5α- or discontinued, designer drugs, substances approved androstan-3-one); only for veterinary use) is prohibited at all times. Methyldienolone (17β-hydroxy-17α-methylestra-4,9-dien- 3-one); ANABOLIC AGENTS Methyl-1-testosterone (17β-hydroxy-17α-methyl-5α- S1 androst-1-en-3-one); Anabolic agents are prohibited. Methylnortestosterone (17β-hydroxy-17α-methylestr-4-en- 3-one); 1. ANABOLIC ANDROGENIC STEROIDS (AAS) Methyltestosterone; a. Exogenous* -
WADA Technical Letter – TL08 USE of INTERNAL STANDARDS
WADA Technical Letter – TL08 TL08 Document Number: Version Number: 3.0 (replaces TL01/2017 version 2.0) Written by: WADA LabEG Approved by: WADA LabEG* Date: 18 January 2017 Effective Date: 18 January 2017 *The approval by the WADA Executive Committee is applicable only to Technical Letters issued after November 2019. USE OF INTERNAL STANDARDS The World Anti-Doping Agency wishes to draw the attention of the Laboratories to the following issues that may affect Laboratory operations. This pertains, in particular, to the selection of internal standards for the analysis of androgenic anabolic steroids (AAS) by chromatographic-mass spectrometric techniques: 1. Use of 17α-Methyltestosterone as internal standard Laboratories shall exercise caution regarding the use of 17α-Methyltestosterone (MT) as an internal standard when analyzing steroids by chromatographic-mass spectrometric techniques. This applies, most importantly, to the Confirmation Procedures. The use of MT as an internal standard may lead to the formation of 17-methyl-5-androstane-3,17-diol and 17-methyl-5-androstane-3,17-diol1 when microbial activity is present in urine Samples and, therefore, to the consequent misinterpretation of the result as an Adverse Analytical Finding. In addition to MT, these artifacts are known Metabolites of various exogenous steroids (e.g. mestanolone, metandienone, oxymetholone, methandriol, and methyl-1- testosterone). Therefore, it is highly recommended that Laboratory Confirmation Procedures for AAS have the following characteristics: Avoid metabolic links between the Presumptive Adverse Analytical Finding and the internal standard e.g. by using deuterated (2H)- or carbon (13C)-labeled internal standards of endogenous steroids instead of MT or any other exogenous AAS; Incorporate solid phased extraction (SPE) to clean up the Sample prior to the enzymatic hydrolysis, since incubating directly already contaminated urine Samples may lead to the formation of microbial degradation artifacts and alter the “steroid profile”.