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CSHL AR 1986.Pdf COLD SPRING HARBOR LABORATORY ANNUAL REPORT 1986 Cold Spring Harbor Laboratory Box 100 Cold Spring Harbor New York 11724 Book designEmily Harste EditorsElizabeth Ritcey, Dorothy Brown, Annette Kirk Photography Susan Zehl, Herb Parsons, David Mick los Cover: Oliver and Lorraine Grace Auditorium (photo by S. Zehl) Contents Officers of the Corporation/Board of Trusteesv Governance and Major Affiliations vi Committeesvii A Tribute to Walter Hines Pageix DIRECTOR'S REPORT 1 DEPARTMENTAL REPORTS 21 Administration23 Buildings and Grounds 24 Public Affairs and Development 25 Library Services27 Publications28 RESEARCH 33 Tumor Viruses35 Molecular Genetics of Eukaryotic Cells79 Genetics93 Cell Biology119 Neuroscience 151 COLD SPRING HARBOR MEETINGS 153 Symposium on Quantitative Biology155 Meetings 165 BANBURY CENTER 269 Director's Report271 Meetings 275 EDUCATIONAL ACTIVITIES 291 Postgraduate Courses 293 Seminars 313 Undergraduate Research 317 DNA Literacy Program319 Nature Study 323 FINANCIAL STATEMENT 325 GRANTS AND CONTRIBUTIONS 333 Financial Support of the Laboratory334 Grants 335 Endowments and Gifts for Facilities340 Annual Giving Programs Corporate Sponsor Program343 Alumni Cabin Campaign 345 Individual Contributions and Memorial Gifts347 Long Island Biological Association348 LABORATORY STAFF 355 (Back row) M. Scharff, B. Clarkson, J.D. Watson, W.H. Page, R.L. Cummings, T Whipple, C. Basilico, H.E. Sampson (Middle row) T.J. Knight, R. Landau, Mrs. G.N. Lindsay, J. Klingenstein, Mrs. S. Hatch, F.M. Richards, G.W. Cutting, Jr. (Front row) O.R. Grace, W.S. Robertson, T.E. Shenk, W. Everdell (Back row) D.L. Luke Ill,B. Clarkson, E. Pulling, T Whipple, Mrs. H.U. Harris, Jr, F.M. Richards, J.R. Warner (Middle row) Mrs. G.N. Lindsay, Mrs. S. Hatch, R. Landau, T.J. Knight (Front row) D.D. Sabatini, J.D. Watson, D. Botstein, T. Maniatis, G.W. Cutting, Jr. These photos, taken at two 1986 meetings, include most board members. Officers of the Corporation Bayard D. Clarkson, M.D., Chairman Taggart Whipple, Vice-Chairman Mrs. Sinclair Hatch, Secretary David L. Luke III, Treasurer James D. Watson, Ph.D., Director G. Morgan Browne, Administrative Director Board of Trustees INSTITUTIONAL TRUSTEES INDIVIDUAL TRUSTEES HONORARY TRUSTEES Albert Einstein College of Medicine Mrs. Charles Dolan Robert L. Cummings Jonathan R. Warner, Ph.D. Oyster Bay, New York Glen Head, New York Columbia University William Everdell Harry Eagle, M.D. Eric R. Kandel, M.D. Glen Head, New York Albert Einstein College of Medicine Harvard University Oliver R. Grace Thomas Maniatis, Ph.D. Oyster Bay, New York H. Bentley Glass, Ph.D. East Setauket, New York Long Island Biological Association Mrs. Henry U. Harris, Jr. George W. Cutting, Jr. Glen Head, New York Walter H. Page Cold Spring Harbor, New York Massachusetts Institute of Technology Mrs. Sinclair Hatch David Botstein, Ph.D. Oyster Bay, New York Edward Pulling Oyster Bay, New York Memorial Sloan-Kettering Cancer Center John Klingenstein Bayard D. Clarkson, M.D. New York, New York New York University Ralph Landau, Ph.D. David D. Sabatini, M.D., Ph.D. New York, New York Princeton University Mrs. George N. Lindsay Thomas J. Silhavy, Ph.D. Laurel Hollow, New York Rockefeller University David L. Luke III James E. Darnell, Jr, M.D. Locust Valley, New York State University of New York, Stony Brook William S. Robertson Sidney Strickland, Ph.D. Huntington, New York Wawepex Society Harvey E. Sampson Townsend J. Knight Cold Spring Harbor, New York Yale University James D. Watson, Ph.D. Frederick M. Richards, Ph.D. Cold Spring Harbor New York Taggart Whipple Oyster Bay, New York Governance and Major Affiliations The Laboratory is governed by a 25-member Board of Trustees which meetsthree or four times a year. Authority to act for the Board of Trusteesbetween meetings is vested in the Executive Committee of the Board of Trustees. The Executive Committee is composed of the Officers of the Board plus any other members who may be elected to the Executive Committee by the Board ofTrustees. Additional standing and ad hoc committees are appointed by the Board of Trustees to provide guidance and advice in specific areas of the Laboratory's operations. Representation on the Board of Trustees itself is divided between community representatives and scientists from major research institutions. Ten such institutions are presently represented on the Board of Trustees: Albert Einstein College of Medicine, Columbia University, Harvard University, Massachusetts Institute of Technology, Memorial Sloan-Kettering Cancer Center, New York University, Princeton University, The Rockefeller University, The State University of New York at Stony Brook, and Yale University. Also represented as participating institutions are the Wawepex Society and the Long Island Biological Association (LIBA). The Wawepex Society was formed in the mid-nineteenth century as a philanthropic arm of the Jones family, who supported the formation of the Laboratory. LIBAs origins began in 1890 when members of the local community became involved as friends and with membership on the Board of Managers of the Biological Station in Cold Spring Harbor, under the aegis of the Brooklyn Academy of Arts and Sciences. When the Brooklyn Academy withdrew its support of the Biological Station, community leaders, in 1924, organized their own association that actually administered the Laboratory until the Laboratory's reorganization as an independent unit in 1962. Today, LIBA remains a nonprofit organization organized under the Department of Social Welfare of the State of New York and represents a growing constituency of "friends of the Laboratory" : Its 500 members support the Laboratory through annual contributions and participation in fund drives to raise money for major construction projects. The Laboratory is chartered as an educational and research institution by the Board of Regents of the Education Department of the State of New York. It is designated as a "public charity" by the Internal Revenue Service. Cornmittees Audit Education Nominating Townsend J. Knight, Chairman Mrs. Charles Dolan, Co-Chairman Taggart Whipple, Chairman Oliver R. Grace Mrs. Henry U. Harris, Jr., Bayard D. Clarkson, M.D. Harvey E. Sampson Co-Chairman George W. Cutting, Jr. Helen Brown, Ph.D. James E. Darnell, Jr, M.D. Mrs. Miner D. Crary, Jr. Harvey E. Sampson Banbury Mrs. Joel M. Fairman David Micklos David Botstein, Ph.D., Chairman Byam K. Stevens, Jr. Eric R. Kandel, M.D. Robertson House Stephen J. Prentis William S. Robertson, Chairman David D. Sabatini, M.D., Ph.D. Executive Mrs. Charles Dolan Sidney Strickland, Ph.D. Mrs. Henry U. Harris, Jr. Jonathan Warner Ph.D. Bayard D. Clarkson, M.D., Chairman Mrs. Walter C. Meier G. Morgan Browne Stephen J. Prentis George W. Cutting, Jr. Jack Richards Building James E. Darnell, Jr, M.D. Oliver R. Grace Mrs. George N. Lindsay, Chairman Mrs. Sinclair Hatch George W. Cutting, Jr Robertson Research Fund Trustees Mrs. George N. Lindsay (Laboratory Representatives) Mrs. Charles Dolan David Luke Ill Oliver R. Grace Harvey E. Sampson David Luke Ill, Chairman Mrs. Henry U. Harris, Jr. James D. Watson, Ph.D. G. Morgan Browne, Jr. Jack Richards Taggart Whipple Bayard D. Clarkson, M.D. Mrs. James D. Watson Mrs. George N. Lindsay James D. Watson, Ph.D. Finance and Investment Commercial Relations (Family Representatives) David Luke Ill, Chairman Taggart Whipple, Chairman Mrs. Robert J. Ernst Ill William Everdell William Everdell Townsend J., Knight Oliver R. Grace Townsend J. Knight Walter C. Meier, M.D. Mrs. Sinclair Hatch Ralph Landau, Ph.D. William S. Robertson John Klingenstein Richard Roberts, Ph.D. Townsend J. Knight Bruce Stillman, Ph.D. William S. Robertson Tenure and Appointments Harvey E. Sampson Taggart Whipple James E. Darnell, Jr., M.D., Chairman Development David Botstein, Ph.D. Mrs. Sinclair Hatch, Chairman Thomas Maniatis, Ph.D. G. Morgan Browne Neurobiology David D. Sabatini, M.D., Ph.D. George W. Cutting, Jr. Eric R. Kandel, M.D., Chairman Mrs. George N. Lindsay John Klingenstein David Micklos William S. Robertson Harvey E. Sampson Charles F. Stevens, Ph.D. Charles R. Thompson Taggart Whipple Officers, Trustees, and Committees as of November 8, 1986 A Tribute to Walter Hines Page Walter H. Page retired in November as chairman of the Board of Trustees, concluding 25 years of active service to the Laboratory and a legacy of family stewardship stretching unbroken for more than 60 years. The Page family's commitment to science at Cold Spring Harbor began in 1924 when Walter's father, Arthur W. Page, became a founding director of the Long Island Biological Association (LIBA). Including 13 years as president, Arthur Page served continuously on the LIBA board until 1958, when Walter became president. Jane Nichols Page (Walter's wife) was LIBA vice-president from 1952-1958. In 1962, Walter led negotiations that culminated in the merger of the Biological Laboratory and the neighboring Carnegie Department of Genetics to form what we now know as Cold Spring Harbor Laboratory. In 1972, he helped bring into existence the Robertson Research Fund, the Laboratory's major endowment. He was elected chairman of the Board of Trustees in 1980. Born in nearby Huntington, Walter attended Milton Academy and graduated from Harvard University in 1937. Choosing a career in banking, he served the Morgan Bank and its successor, the Morgan Guaranty Trust Company, at home and abroad until his retirement in 1979 as chairman of the board. He also served as director of numerous companies, including United States Steel Corporation, the Royal Group, Inc., and the Saudi International Bank. Over the years, the Laboratory has benefited from the counsel of this truly wise man and from his consummate business acumen. We look forward to his continued advice as an honorary trustee and caring neighbor. DIRECTOR'S REPORT Our genetic uniqueness, like that of all other forms of life, is determined by the information present in DNA, the chromosomally located chemical substance out of which our genes are made.
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