Microbiology KU Medical Center Molecular Virology and Pathogenesis (MICR 812) Location of Classes: TBD A. Contact Information Jianming Qiu, Ph.D. 4004 Hixon 588‐4329
[email protected] B. Purpose of this Course This Virology course is aimed at graduate students who pursue master degree in science in the Department of Microbiology. It provides a contemporary understanding of how viruses are built, how they infect and replicate in host cells, how they spread and evolve, how they interact with host cells, how they eventually cause diseases, and how infection of a host can be prevented. This course will provide a balanced approach to Virology, combining the molecular and pathogenesis aspects of Virology. While it is focused primarily on human viruses, it will also discuss animal viruses, as human viruses often are evolved from animal viruses. In addition to traditional topics, this course will explain new “hot” trends in Virology, including: virus‐based vector in human gene therapy; modern advances in vaccinology; “oncolytic” viruses to treat cancers; emerging viruses and potential bioterrorism agents (influenza virus, coronavirus, and filoviruses). C. Intended Course Outcomes By the end of this course, students should be able to: 1. Describe virus taxonomy, virus structure and virus entry, trafficking and egress. 2. Describe the basics of the viral gene expression, including viral replication, transcription, post‐transcriptional regulation, translation and post‐translational regulation of virus genes. 3. Apply techniques used in modern virology and design experiments to test novel hypotheses in virology. 4. Distinguish diverse characteristics of viruses – host range, target tissues, replication strategy, transmission, etc., in particular, of these emerging/reemerging viruses, e.g., influenza and Ebola viruses, and medical important viruses, e.g., HIV.