Authors: Pallavi Subhraveti Ron Caspi Tomer Altman Quang Ong An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Peter D Karp Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Ecol413997Cyc: Escherichia coli B str. REL606 Cellular Overview Connections between pathways are omitted for legibility. Alexander Shearer D-alanine 4-amino-4- undecaprenyldiphospho- undecaprenyldiphospho- Co 2+ 2+ succinateL-tartrate α Co 2+ D-serine leu deoxy- -L- N-acetyl-(N- N-acetyl-(N- Ni Mg 2+ 2+ melibiose an apo-[c-type gly arabinopyranosyl acetylglucosaminyl) acetylglucosaminyl) Mg Mg 2+ partially N- β cytochrome] antimonous acid glutathione ditrans,octacis muramoyl-L-alanyl- muramoyl-L-alanyl- N-acetyl- -D-mannosamine 1,6- deacetylated an ion an ion cys γ γ GlcNAc anhydro- with reduced a sugar alcohol homoserine lactone -undecaprenyl succinate -D-glutamyl-meso- -D-glutamyl-meso- L-2-hydroxybutyrate L-2-hydroxybutyrate D-tartrate Li + magnesium hydrogenphosphate melibionate poly-β-1,6- poly-β-1,6- an organosulfur compound an organosulfur compound an L,L-homocystine met L-homoserine N-acetyl-D- galactitol β L-cysteine an an aromatic urea L-homoserine thr phosphate 2,3-dioxo- α,α- 2,6-diaminopimeloyl- 2,6-diaminopimeloyl- glycolate glycolate methyl-β-D- a lipopolysaccharide 5-dehydro-D-gluconate 2-deoxy-D-glucose methyl α-D-glucoside methyl-α-D-galactopyranoside calcium hydrogenphosphate antimonous acid D-mannitol D-mannitol 2-O-α- D-fructose N,N'- N-acetyl- - N-acetyl-D- lactulose N-acetyl-D- N-acetyl-D- β-D- arbutin-6-phosphate a short-chain carboxylate a short-chain carboxylate oligopeptide D-cystine ser fumarate fumarate galactosamine L-arabinose D-sorbitol succinate α α D-glycerate D-glycerate β-D- D-fructose L-ascorbate β residues amino acid leu thr a C4-dicarboxylate L-gulonate succinate trehalose D-alanyl-D-alanine D-alanyl-D-alanine methyl-β-D- a lipopolysaccharide D-mannitol acetate -lactose -lactose D-fructuronate L-idonate β-D-glucose salicin β-D-glucose melibiose melibionate arsenite D-sorbitol L-rhamnose mannosyl- D-mannose β-D-galactose maltose diacetylchitobiose aldehydo-L- N-acetyl- -D-glucosamine(anhydrous)-N-acetylmuramate muramate muramate 3-hydroxy-trans-cinnamate melibiose glucosamine p-aminobenzoyl cellobiose arbutin methyl β-D-glucoside 6-phosphate N,N'- oligopeptide L-cystine [+ 3 more] shikimate thr thr acetoacetate fumarate 2-oxoglutarate D-galactosamine (R)-lactate (R)-lactate galactoside sulfate GlcNAc D-gluconate D-gluconate arsenate ribopyranose D-galactonate psicoselysine salicin glucosamine [+ 27 more] [+ 27 more] H O orotate fumarate galactoside D-sorbitol succinate D-gluconate β melibiose β-L-lyxopyranose D-glycerate D-glucopyranose β-D-glucose galactonate GlcNAc-1,6-anhMurNAc-L-Ala-γ-D-Glu-DAP-D-Ala 3-(3-hydroxyphenyl)propionate [+ 2 more] glutamate β-D-cellobiose diacetylchitobiose 2 S-sulfo-L-cysteine glutathione D-gluconate -D-glucose N-acetyl- galactitol mannitol- putative leucine / L- / L-cysteine undecaprenyl- 2,3-diketo-L- trehalose- arabinose mannose- glucose- sorbitol- mannose- N,N'- fructose- L-ascorbate N-acetylmuramic N-acetylmuramic N,N'- oligopeptide galactosamine lipopolysaccharide / sorbitol specific ribose ABC Sec Holo- oligopeptide UspT GlpF CycA YifL ShiA YpjD CsrD FhuF YbjM IgaA YgjV RarD YceL LeuE phenylalanine ABC TdcC RhtB RhtA RhtC 01127 YgiY DctA FtsY YfgO YoaD YfcA YgiS phosphate-α-L- AtoE gulonate:Na + DcuA DauA DcuC DcuC YeaV specific PTS KgtP EIIAga MurJ FtsW 03695 CorA MgtA LldP GlcA HtpX MelB MglBAC ABC MsbA MtlA SatP DcuB TtdT CysZ NagE SetB SetA YhcB GntU GntT GntP IdnT specific PTS BglF specific PTS GarP GudP MelB MelB MelB PitB ArsB specific PTS RhaT HrsA specific PTS GalP 01590 diacetylchitobiose- specific PTS specific PTS DgoT LgoT AmpG FrlA acid-specific acid-specific MhpT ElaB YhcL RodZ PspA LacY AscF EttA PgaCD PgaA AbgT Blr diacetylchitobiose- AscF BglF FecR ChiP PhoE OmpF AqpZ ABC YdcL YddG TcyP YhgN DnaA transporter transport system PTS PTS enzyme transporter Translocon ABC ABC transporter exporter Ara4N flippase symporter enzyme II transporter enzyme II enzyme II enzyme II enzyme II specific PTS enzyme II enzyme II enzyme II PTS enzyme II PTS enzyme II specific PTS enzyme II transporter complex permease II CmtBA transporter YhiM CydDC β YfhM antimonous acid homoserine lactone undecaprenyldiphospho- undecaprenyldiphospho- L-2-hydroxybutyrate L-2-hydroxybutyrate methyl- -D- magnesium hydrogenphosphate antimonous acid poly-β-1,6- partially N- arbutin an ion an ion met L-homoserine 2+ β a lipopolysaccharide α-lactose α-lactose β an aromatic D-alanine fumarate D-galactosamine 2+ Co galactoside methyl- -D- D-mannitol 1-phosphate N-acetyl-D- D-fructuronate 5-dehydro-D-gluconate salicin 6-phosphate D-glycerate D-glycerate methyl-α-D-galactopyranoside L-rhamnose 2-O-(6- -D-galactose maltose aldehydo-L- β melibionate salicin 6- arbutin-6-phosphate methyl β-D-glucoside an apo-[c-type N,N'- L,L-homocystine a sugar alcohol L-homoserine thr a C4-dicarboxylate 4-amino-4- succinate N-acetyl-(N- N-acetyl-(N- Co 2+ glycolate glycolate a lipopolysaccharide acetate calcium hydrogenphosphate arsenite β N-acetyl- -D-glucosamine(anhydrous)-N-acetylmuramate 3-hydroxy-trans-cinnamate N-acetyl-D- deacetylated p-aminobenzoyl an organosulfur compound an organosulfur compound shikimate leu ser thr acetoacetate fumarate fumarate 2-oxoglutarate 2+ Mg succinate succinate sulfate D-gluconate D-gluconate melibiose melibiose β β -D- D-galactonate psicoselysine H O amino acid α α 2+ galactoside glucosamine D-gluconate L-idonate β α melibionate -L-lyxopyranose D-glucopyranose -D-glucose β galactonate β lactulose β β cytochrome] diacetylchitobiose 2 urea D-serine thr orotate deoxy-α-L- 2,3-dioxo- fumarate , - 6-phosphate acetylglucosaminyl) acetylglucosaminyl) Mg Ni (R)-lactate (R)-lactate D-sorbitol 6-phosphate succinate -D-glucose 6-phosphate methyl -D-glucoside 6-phosphate arsenate D-mannitol 1-phosphate phospho- N-acetyl-D-mannosamine 6-phosphate N,N'- -D- L-ascorbate GlcNAc-1,6-anhMurNAc-L-Ala-γ-D-Glu-DAP-D-Ala 1,6- N-acetyl- - 3-(3-hydroxyphenyl)propionate phosphate glucosamine poly-β-1,6- glutamate -D- -D-cellobiose 6'-phosphate a short-chain carboxylate a short-chain carboxylate an D-cystine glutathione thr N-acetyl-D- 2+ L-arabinose galactitol 1-phosphate 2-deoxy-D-glucose 6-phosphate + D-mannitol ribopyranose gly leu succinate trehalose 6- Mg D-tartrate L-tartrate 6-phosphate D-gluconate β-D-glucose 6-phosphate Li melibiose D-sorbitol 6-phosphate α-D- N-acetyl-D-glucosamine 6-phosphate diacetylchitobiose fructofuranose 6-phosphate anhydro- muramate 6- melibiose cellobiose 6'- with reduced an L-cystine [+ 3 more] cys arabinopyranosyl L-gulonate muramoyl-L-alanyl- muramoyl-L-alanyl- galactosamine β-D-glucose 6-phosphate N-acetyl-D- [+ 27 more] [+ 27 more] oligopeptide D-sorbitol 6-phosphate 1-phosphate β [+ 2 more] L-cysteine oligopeptide ditrans,octacis phosphate γ-D-glutamyl-meso- γ-D-glutamyl-meso- mannosyl)- F6P 6'-phosphate 1-phosphate N-acetyl- - phosphate glucosamine phosphate S-sulfo-L-cysteine UbiB 6-phosphate α residues -undecaprenyl 2,6-diaminopimeloyl- 2,6-diaminopimeloyl- D-glycerate -D-mannose 6-phosphate muramate HokC phosphate D-alanyl-D-alanine D-alanyl-D-alanine YdeP YjbE Amino Acid Biosynthesis C1 Compound Utilization 6 a cleaved YihY and Assimilation a peptidoglycan a nascent peptidoglycan a mature peptidoglycan a peptidoglycan dimer an O - a [protein]- a [chaperone- 1-myristoyl- 3-oxo-(9Z)- 1-chloro-2,4- p-aminobenzoyl 3-oxo-(5Z)- (S)-1-pyrroline- a (3R,7Z)-3- a cis-delta9-3- a [protein]- superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis superpathway of tryptophan biosynthesis sn-glycerol a cis- sn-glycerol an unsulfurated glutathione an N-modified palmitoyl-CoA H O an acyl-CoA H O Carbohydrate Degradation γ γ methylguanine ADP]-[disordered- cys 2 2 hydroxyhexacos- hydroxyC28:1- lipoprotein superpathway of superpathway of leucine, valine, and isoleucine biosynthesis cysteine biosynthesis I superpathway of asparagine biosynthesis proline biosynthesis I superpathway of serine superpathway of aspartate and asparagine biosynthesis; Fermentation mixed acid fermentation N-acetyl-galactosamine with (L-alanyl- -D- with (L-alanyl- -D- (meso-diaminopimelate with pentapeptide L-cysteine sn-glycerol a palmitoleoyl-[acp] octadecenoyl-CoA a myristoyl-[acp] dinitrobenzene glutamate L-cystathionine dodecenoyl-CoA aminoacyl-[tRNA] 5-carboxylate GMP L-tyrosine GMP OpgH histidine biosynthesis galactosamine L-lyxose L-rhamnose fucose degradation 3-phosphate vaccenoyl-[acp] 3-phosphate [sulfur carrier] signal peptide tyrosine phenylalanine biosynthesis and glycine biosynthesis I interconversion of aspartate and asparagine degradation formaldehyde oxidation glutamyl-meso-2,6- glutamyl-meso-2,6- containing) stems (meso- in DNA form scaffold 3-phosphate fused DNA- 7-enoyl-[acp]3-oxoacyl- [acp] 3-oxoacyl- signal MalM YqiI D-erythrose D-erythrose Secondary Metabolite Biosynthesis degradation degradation degradation I kinase: phosphoenolpyruvate N-acetyl-D- II (glutathione-dependent) diaminopimeloyl-D- diaminopimeloyl- diaminopimelate protein] complex binding [ACP] [ACP] peptide GMP 4-phosphate 4-phosphate D-erythrose phosphoenol pyruvate 3-phospho- phosphoenolpyruvate β-L-fucopyranose 3-ketoacyl- glutathione S- p-aminobenzoyl- 3-ketoacyl- acyl-CoA acyl-CoA thr ser asp PRPP glt alanine) tetrapeptide D-alanyl-D-alanine) containing) 6 transcriptional wzc glt asp asn galactosamine β α-L-rhamnopyranose peptidoglycan lytic O -alkylguanine- acyl-[acp]:1-acyl- acyl-acp:sn- acyl-acp:sn- L-cysteine cystathionine peptidyl- reductase: reductase: peptidase: reductase: 3-deoxy-7- 4-phosphate pyruvate serine glutamate D-glycerate methylerythritol phosphate pathway D-galactosamine -L-lyxopyranose formaldehyde CoA transferase: glutamate CoA thioesterase: thioesterase: YmgF acetolactate D-3- pentapeptide endotransglycosylase: DNA- non- sn-glycerol-3- desulfurase: β-lyase: malY tRNA repressor GMP fabG fabG sppA protein- guaC 3-deoxy-7- ATP aspartate L-aspartate:ammonia L-asparaginase: autoinducer AI-2 biosynthesis I N-galactosamine L-lyxose L-fucose thiolase: glycerol-3- glycerol-3- yfcF hydrolase: thiolase: tesB yciA phosphoheptulonate threonine acetyltransferase: 5-kinase: phosphoglycerate pyruvate kinase: pykF phosphoenolpyruvate galactosamine L-rhamnose mltD N-acetylmuramoyl- sufS / proline nucleosidase: tyrosine synthase: phosphoribosyltransferase: transaminase: ligase (AMP- ansA D-glyceraldehyde phosphorylase/ isomerase: mutarotase: fucU alkyltransferase: chaperonin phosphate 2-O- phosphate 1-O- phosphate 1-O- abgA abgB cystathionine fadA hydrolase: 3-ketoacyl- 3-ketoacyl- lipoprotein YjhB SfmC YcbU synthase: aroG phosphoheptulonate 3-deoxy-7- deaminase: cysE L-aspartate:ammonia L-aspartate:L- proB dehydrogenase: serA pyruvate pyruvate kinase: pykA carboxylase: ppc mutarotase: peptidoglycan DD- fadA glutathione S- acyl-CoA acyl-CoA dehydrogenase ppnN kinase: etk IMP ilvB ilvN hisG L-glutamate 3-phospho- aspC forming): asnB L-asparaginase translocase: phosphorylase rhaA 2-O-α-mannosyl-D- peptidoglycan lytic L-alanine ogt molecular acyltransferase: acyltransferase acyltransferase cysteine β-lyase: metC arfB (acyl-carrier- (acyl-carrier- signal a [protein]- [+ 2 isozymes] synthase: aroG phosphoheptulonate ilvA O-acetyl-L-serine ligase (AMP- glutamine amido- 3-phosphate rhaM α-L-fucopyranose transpeptidase: acetyl-CoA C- transferase: acetyl-CoA C- thioesterase: thioesterase: / 1-pyrroline- [+ 3 isozymes] 5-phosphate hydroxypyruvate asp II: ansB SAM agaW agaE and translocase: L-xylulose glycerate degradation S-hydroxymethylglutathione endotransglycosylase: amidase: amiB chaperone plsC (glycerol-3- (glycerol-3- desulfurase: peptidyl- protein) protein) peptide L-tyrosine 3-deoxy-D-arabino- [+ 2 isozymes] synthase: aroG forming): asnB ligase (AMP- asparagine mrcA O-6-methylguanine- acyltransferase: gstA acyltransferase: yciA tesB 5-carboxylate threonine 1-(5-phospho-β-D-ribosyl)-ATP asp oxaloacetate agaC agaB β mltC ATPase: hscA phosphate phosphate iscS 4-aminobenzoate D-ribose 5- reductase: reductase: peptidase: phosphate heptulosonate- [+ 2 isozymes] O-acetylserine forming): asnB glutamate-5- 3-phosphoserine synthetase: 1-deoxy-D- pyruvate agaV agaF -L-rhamnopyranose L-fucose 2-O-(6-phospho- S-(hydroxymethyl) DNA fadI glt fadI tRNA (S)-2-acetolactate dehydratase: asparagine agaD agaF L-xylulose [+ 2 isozymes] γ pyruvate dehydrogenase phosphate WcaD 3-deoxy-D-arabino- sulfhydrylase: cysK semialdehyde aminotransferase: aspartate asnA xylulose-5- N-acetyl-D- α-D-mannosyl) a peptidoglycan dimer L-alanyl- -D- methyltransferase: 1-myristoyl-2- acyltransferase) acyltransferase) L-homocysteine hydrolase: guanine ECB_04076 ECB_04076 rseP 7-phosphate tdcB synthetase: asnA kinase: L-rhamnose isomerase: fucI glutathione PutA: putA a (7Z)-3- a (9Z)-3- YjfY Lpp heptulosonate- 3-deoxy- phosphoribosyl-ATP dehydrogenase: ammonia- malate galactosamine D-galactosamine glucose and glucose-1-phosphate degradation a nascent peptidoglycan with pentapeptide stem glutamyl-meso-2,6- ada : plsB : plsB 2,4-dinitrophenyl- pth (2R)-2,3-dihydroxy-3- O-acetylserine serC asn phosphate SAH D-lactate lyxK isomerase: -D-glycerate dehydrogenase: frmA a mature peptidoglycan a mature peptidoglycan a [disordered- an [Fe-S cluster palmitoleoyl- palmitate a carboxylate oxohexacos- oxooctacos- a peptide YjiN 3-dehydroquinate (2Z)-2-aminobut- pyrophosphatase: hisI lyase: aspA dehydrogenase: mdh 6-phosphate L-fuculose (meso-diaminopimelate diaminopimeloyl- (7Z)- a sulfurated S-glutathione (3Z)-dec-3- 7-phosphate D-arabino- methylbutanoate:NADP + sulfhydrylase: cysM asn proA synthase: dxs 6-phosphate α with D,D cross-links D-alanine with (L-alanyl-γ-D- strand (non- form [Fe-S] cluster biosynthesis sn-glycerol acetyl-CoA ala acetyl-CoA glt 7-enoyl-[acp] 9-enoyl-[acp] synthase: aroB 3-phospho- dehydrogenase: ldhA L-xylulose - rhaA -D-glucose hexadecenoyl-CoA [sulfur carrier] heptulosonate- 2-enoate N-acetylgalactosamine- 2-O-(6- S-formylglutathione (meso-diaminopimelate glutamyl-meso-2,6- reducing terminus) containing) D-alanyl-D-alanine scaffold protein] chaperone]-ATP 3-phosphate 1-myristoyl- 1-cis-vaccenoyl- enoyl-CoA 3-dehydroquinate oxidoreductase asn 1-(5-phospho-β-D-ribosyl)-AMP L-glutamate-5- L-serine fumarate S-adenosylhomocysteine (S)-malate 5-phosphate L-fuculokinase: 1-phosphate a [protein]-S- 7-phosphate cys 1-deoxy-D-xylulose 6-phosphate keto-L-rhamnulose phospho-α- containing) diaminopimeloyl-D- a guanine in DNA sn-glycerol sn-glycerol- an N-modified 3-dehydroquinate synthase: aroB (isomerizing): ilvC semialdehyde nucleosidase: mtn fucK S-formylglutathione methyl-L-cysteine a tRNA PspG (R)-2,3- phosphoserine 5-phosphate (R)-lactate formate acetyl-CoA deacetylase: agaA putative L- mannosyl)- alanine) tetrapeptide 3-phosphate 3-phosphate amino acid YbaV FimI 3-dehydroquinate phosphoribosyl-AMP fumarase C: fumC D-tagatofuranose α-D-glucose- phosphoglucomutase: hydrolase: yeiG 3-dehydroquinate dihydroxy-3- phosphatase: S-ribosyl-L- D-galactosamine xylulose 5- D-glycerate 3-dehydroquinate synthase: aroB cyclohydrolase: hisI 1-deoxy-D-xylulose [+ 4 isozymes] 6-phosphate L-fuculose 1-phosphate 1-phosphate pgm methylbutanoate 2-iminobutanoate serB homocysteine 6-phosphate phosphate 3- hydrolase: S-formylglutathione SohB dehydratase: aroD 1-(5-phospho-β-D-ribosyl)- 5-phosphate formate hydrogenlyase phosphate acetaldehyde citrate synthase: gltA phosphatase: undecaprenyldiphospho-N-acetyl- a peptidoglycan a nascent peptidoglycan an O 4 - a nascent peptidoglycan L-alanyl-γ-D- poly-β-1,6- β an oxidized queuosine at a (3R,5Z)-3- 3-dehydroquinate 3-dehydroquinate tagatose-6- epimerase: hydrolase: frmB a nascent peptidoglycan a [protein]- a 2,3,4-saturated methyl -D-glucoside a nucleoside 2,3-dihydroxy- 5-[(5-phosphoribosylamino) (S)-1-pyrroline- reductoisomerase: dxr complex: hycD acetyltransferase: eutD dehydrogenase: mhpF fumarate L-rhamnulofuranose α-D-glucose mngB γ γ γ methylthymine γ 1-palmitoylglycerol acetate prephenate sn-glycerol a purine a glutamine PPP stearoyl-CoA H O a cytidine 34 L-methionine- L-methionine- ATP dehydratase: aroD ser S-ribosylhomocysteine phosphate sgbU L-fuculose yihX (N-acetylglucosaminyl)muramoyl- with (L-alanyl- -D-glutamyl- with (L-alanyl- -D- with (L-alanyl- -D- L-cysteine with (L-alanyl- -D-glutamyl- a myristoyl-[acp] fatty acyl CoA SAM a palmitoyl-[acp] glutamyl-L-lysyl- N-acetyl-D- ATP 6-phosphate i RNA 2 nitroaromatic glt position 34 lys hydroxytetracos- 3-dehydroshikimate isovalerate 3-phosphate 3-phosphate synthetase triphosphate Ile2 (R)-S-oxide (S)-S-oxide XTP DcrB YraK methylideneamino]imidazole- 5-carboxylate lyase: luxS hycC hycF hycG phosphate [+ 2 isozymes] 6-phosphate formate L-alanyl-γ-D-glutamyl-meso-2,6- meso-2,6-diaminopimeloyl-D- glutamyl-meso-2,6- glutamyl-meso-2,6- in DNA meso-2,6-diaminopimeloyl-D- D-alanyl-D-alanine ribonucleoside glucosamine compound of a tRNA Asp in tRNA 5-enoyl-[acp] Ap A YqeG 3-dehydroquinate MEP citrate kinase: pfkB phosphate [+ 4 isozymes] α NADPH- 3-oxoacyl- methionine- methionine- 4 dehydratase: 4-carboxamide hycB hycE fdhF acetyltransferase: pta fumarate reductase: L-xylulose 5- rhamnulokinase: -D-mannose synthetase: shikimate 3-dehydroshikimate dehydratase: aroD pyrroline-5- 5,10-methylenetetrahydrofolate:glycine (S)-4,5- D-tagatofuranose D-tagatofuranose aldolase: fucA D-glycerate diaminopimeloyl-D-alanyl-D-alanine alanyl-D-alanine) pentapeptide diaminopimeloyl-D- diaminopimeloyl-D- alanyl-D-alanine) pentapeptide [ACP] (R)-sulfoxide S-sulfoxide ilvD frdA frdD frdC frdB phosphate 3- rhaB 6-phosphate fused predicted methyl β-D- inorganic acyl-CoA dependent XTPase: dehydrogenase: 2-oxobutanoate 1-(5-phosphoribosyl)-5- carboxylate hydroxymethyltransferase: glyA dihydroxypentan- acetaldehyde citrate hydro-lyase: acnB 6-phosphate 1,6-bisphosphate alanine) tetrapeptide alanine) tetrapeptide O-4-methylthymine- acyl-[acp]:1-acyl- carboxy-S- D-alanyl-D-alanine glutamine synthetase DNA- tRNA Ile - reductase: reductase: reductase: entE 2-C-methyl-D- epimerase: D-glucopyranose acetyl- acyl-acp:sn- glucoside 6- triphosphatase: thioesterase: nitroreductase glutamyl-Q ZipA shikimate 3-dehydroshikimate 3-methyl-2- [(5-phosphoribosylamino) reductase: 2,3-dione citrate hydro-lyase (cis- L-rhamnulose glycerate DNA adenosyl-L- purine nucleoside directed RNA Ap A yjjX aroE erythritol 4-phosphate CO H acetyl phosphate succinate tagatose-6- peptidoglycan D-alanyl-D-alanine sn-glycerol-3- glycerol-3- carboxypeptidase: adenylyltransferase: NfsA: nfsA tRNA(Asp) lysidine fabG msrC bisC 4 oxobutanoate acetohydroxybutanoate superpathway of lysine, threonine and methionine biosynthesis I methylideneamino]imidazole-4- 2 2 ethanol ulaE 1-phosphate DHAP L-lactaldehyde 2-kinase: CoA:acetoacetyl- methionine phosphate ygiF tesB dehydrogenase: proC gly cytidylyltransferase: aconitate-forming): acnA L,D- methyltransferase: phosphate 2-O- dacD phosphorylase: glnE polymerase synthetase: synthetase: FtsP YgiL shikimate phosphate tagatose-1,6- L-ribulose 5- glucose glycosyltransferase: carboxypeptidase: CoA transferase: phosphate 1-O- glucohydrolase: acyl-CoA NAD(P)H synthetase: 3-ketoacyl- methionine methionine aroE shikimate synthase: ilvB ilvN carboxamide isomerase: hisA dehydrogenase: adhE garK transpeptidase: ada acyltransferase: synthase: deoD inorganic subunit tilS lysU XDP UspB dehydrogenase: 2-isopropylmalate ispD acetate kinase: purT kinase: pfkB bisphosphate phosphate dehydrogenase: mrcA dacD α subunit/β acyltransferase D-alanyl-D-alanine bglA nitroreductase: gluQ (acyl-carrier- sulfoxide sulfoxide valine [+ 2 isozymes] oxaloacetate pro cis-aconitate rhamnulose- glycerate 4 cmoA triphosphatase: thioesterase: ydiB shikimate dehydrogenase: phosphoribulosylformimino- superpathway of alanine biosynthesis 4-(cytidine 5'- (2R,4S)-2-methyl-2,4- ethanol aldolase: ldtD O -methylthymine- plsC (glycerol-3- partially N- adenylyl- alpha: rpoA synthase: leuA transaminase: acetate kinase: ackA D-tagatofuranose L-ribulose-5- 1-phosphate gcd [+ 2 isozymes] [+ 5 isozymes] subunit: ydiF carboxypeptidase: acetate ppa yciA a hydroxylaminonfsB protein) reductase: reductase: Ap4A dehydrogenase: aroE (S)-2-aceto-2- AICAR-P diphospho)-2-C- dehydrogenase: adhP β-D-glucose 2-kinase: DNA α-D-ribose- deacetylated poly- [+ 2 isozymes] dihydroxydihydrofuran- D-threo-isocitrate 1,6-bisphosphate kbaY kbaZ phosphate dacA [glutamine group-containing glutamyl- a lysidine 34 reductase: msrB msrA ilvE hydroxybutanoate aspartate pyruvate fermentation phosphate 4- aldolase: rhaD glxK carboxy-S- 2-oxo-3- β-1,6-N-acetyl- β-D-glucose Uup shikimate ydiB shikimate methyl-D-erythritol methyltransferase: ogt 1-phosphate synthase] Ile2 Lpp YdeQ (2S)-2- 3-one acetate ethanol hydro-lyase: acnB tagatose- D-allose D-glucono- a nascent peptidoglycan a nascent peptidoglycan a nascent peptidoglycan 1-palmitoyl-2-myristoyl acyltransferase) a purine base methanol compound queuosine at in tRNA a (5Z)-3-ECB_04076 met met dehydrogenase: (R)-2,3-dihydroxy-3- transaminase: aspC imidazole glycerol 3-methyl-2-oxobutanoate 4-(cytidine 5'- to ethanol I epimerase: glucokinase: 2-phospho- di-trans,octa-cis- adenosyl-L- phenylpropanoate D-glucosamine 6-phosphate isopropylmalate D-threo-isocitrate tagatose-1,6- bisphosphate degradation with (L-alanyl-γ-D-glutamyl- with L,D cross links D-alanine with (L-alanyl-γ-D-glutamyl- D-alanine acetyl-CoA a fatty acid : plsB L-alanyl-γ-D- position 34 shikimate shikimate + araD 1,5-lactone phosphatidate methionine phosphate diphosphate stearate oxotetracos- ydiB methylpentanoate:NADP phosphate diphospho) DHAP glk D-glycerate undecaprenyl diphosphate RNA Asp YcdZ val cys valine hydro-lyase (cis- bisphosphate aldolase: gatY L-lactaldehyde meso-2,6-diaminopimeloyl-D- (meso-diaminopimelate a [protein]-S- meso-2,6-diaminopimeloyl- glutamyl-L- of a tRNA kinase: aroL (2S)-2- oxidoreductase asp synthase: hisF hisH -2-C-methyl- pyruvate [+ 2 isozymes] D-allopyranose a thymine in DNA D-alanine 5-enoyl-[acp] shikimate transaminase: ilvE aconitate-forming): acnA aldolase: β-D-glucose alanyl-D-alanine) pentapeptide containing) methyl-L-cysteine D-alanine) tetrapeptide lysyl-D-alanine shikimate shikimate isopropylmalate (isomerizing): ilvC homoserine and D-erythritol D-xylulose D-allose 1-palmitoylglycerol kinase: aroL AI-2 kbaY kbaZ D-glyceraldehyde 6-phosphate SecM YejO kinase: aroK hydro-lyase (2- aspartate D-erythro-imidazole- methionine biosynthesis pyruvate kinase: ispE preQ biosynthesis D-threo-isocitrate DHAP 5-phosphate kinase: 3-phosphate shikimate (R)-2,3-dihydroxy- AICAR L-cysteine:[protein 0 3-phosphate YbiO shikimate isopropylmaleate- kinase: thrA val 2-phospho-4-(cytidine tagatose- alsK D-gluconate kinase: 3-methylpentanoate glycerol-phosphate cysteine] aldehydo-D-allose ribose L-arabinose shikimate 3-phosphate kinase: aroK forming): leuC leuD [+ 2 isozymes] 5'-diphospho)-2-C- isocitrate bisphosphate acetoin degradation YiaA aroL 2,3-dihydroxy-3- imidazoleglycerol- asp glutamate--pyruvate sulfurtransferase: degradation degradation I methyl-D-erythritol aldolase: gatY 6-phosphate N 6 -(3-methylbut- an inactive a CcmE-[c-type a CcmG protein 3-O-β-D- β N,N'- a peptide with a [protein] a (3R,6Z)-3- adenylyl- a [disulfide-bond acetyl-CoA formate dehydrogenase: icd L-Ala-γ-D-Glu- α -D-cellobiose + shikimate 3-phosphate 2-isopropylmaleate methylvalerate phosphate aminotransferase: alaC iscS valine--pyruvate GTP a sulfurated UDP-N- -D- 1-palmitoylglycerol a (4Z)-hexadec- a (5Z)-tetracos- a cis-delta13- a cis-delta9- a carboxylic ester NADP FMNH carbamoyl- GDP 3-phosphoshikimate 1- shikimate L-aspartyl-4-phosphate 2-C-methyl-D- allose-6- β 2-en-1-yl)- ribonucleoside SAM cytochrome-- with reduced a palmitoyl-[acp] a malonyl-[acp] a malonyl-[acp] a malonyl-[acp] a malonyl-[acp] a protein galactopyranosyl- 6'-phosphate DL-allothreonine 2 diacetylchitobiose an N-terminal C-terminal glt HypE hydroxyoctadec- [glutamine carrier protein] aspartate GTP acetoin -D-ribopyranose L-arabinopyranose meso-DAP-D-Ala acetylmuramate 4-enoyl-[acp] 5-enoyl-[acp] C32:1-[acp] C28:1-[acp] ITP YbcL YdeR carboxyvinyltransferase: kinase: hydro-lyase: ilvD dehydratase: hisB glutamate--pyruvate L-cysteine aminotransferase: acetaldehyde D-glyceraldehyde trehalose degradation [sulfur carrier] 37 3-phosphate L-methionine phosphate synthase] with reduced L- nucleoside kinase: thrA erythritol 2,4- 2-oxoglutarate DHAP phosphate D-ribose L-arabinose adenosine triphosphate CcmH disulfide] cysteine residues D-arabinose L-glutamate 6-enoyl-[acp]3-oxoacyl- 3-phosphoshikimate 1- aroK (2S)-2- desulfurase: sufS avtA cyclohydrolase dehydrogenase: 3-phosphate I (low osmolarity) trehalose degradation protein aroA (S)-3-methyl-2- aspartate- aminotransferase: alaA cyclodiphosphate 7,8- isomerase: pyranase: isomerase: in tRNA reductase complex chitin [ACP] cysteine residues di- and YoaE carboxyvinyltransferase: isopropylmalate imidazole acetol-phosphate [+ 2 isozymes] I: folE II (trehalase) UDP-N-acetylmuramate:L- carboxylesterase: putative 6- FMN disulfide ITPase: 5-enolpyruvyl- oxopentanoate semialdehyde synthase: ispF mhpF α α rpiB rbsD β β β β methionine carbamoyl- triphosphate MreD aroA shikimate 3- hydro-lyase (2- dihydroneopterin , -trehalose araA γ acyl-[acp]:1-acyl- -ketoacyl -ketoacyl -ketoacyl -ketoacyl aminopeptidase: galactoside- bioH phospho-beta- allothreonine reductase: disaccharide ribosomal reductase: glutamine isoleucine L-aspartyl- [+ 2 isozymes] D-allulose 6- isopentenyl- alanyl- -D-glutamyl-meso oxidase hydrolase: yjjX shikimate 3-phosphate phosphate isopropylmaleate- dehydrogenase: asd histidinol-phosphate 2-C-methyl-D-erythritol- triphosphate 6-phosphate α,α-trehalose D-ribose L-ribulose ribonucleoside thiol:disulfide sn-glycerol-3- [acyl-carrier [acyl-carrier [acyl- [acyl- ypdF arabinose acetaldehyde- deacetylase: aminopeptidase: protein S6 -[HypE] fabG synthetase 5-enolpyruvyl- transaminase: 4-phosphate ala adenosine tRNA -diaminoheptanedioate- carboxylesterase: glucosidase: ssuE (quinone) nudJ MarB SfmA aminotransferase: 2,4-cyclodiphosphate 6-carboxy-5,6,7,8- phosphate pyranase: triphosphate oxidoreductase: phosphate 2-O- protein] protein] carrier carrier aminopeptidase: galactohydrolase: lyase (glycine- chbG map modification: ligase: hypF 3-ketoacyl- deadenylase: a [disulfide- chorismate shikimate 3-phosphate 3-phosphoshikimate 1- forming): leuC leuD acetaldehyde Pentose Phosphate Pathways acetaldehyde acetyl-CoA methylthiolase: D-alanine ligase: mpl yjfP glvG FMN : dsbB ilvE L-aspartate-semialdehyde hisC tetrahydropterin trehalose-6- D-allulose-6- fucU ribulokinase: reductase ccmG acyltransferase: synthase: fabB synthase: fabB protein] protein] lacZ forming): glyA rimK glnE IDP synthase: carboxyvinyltransferase: (2R,3S)-3- aspartate- alanine superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass xylose trehalase: treF mtfA (acyl-carrier- bond carrier GMP chorismate synthase: queD β araB miaB synthase: [+ 3 isozymes] reductase: aroC isopropylmalate semialdehyde racemase: dadX ethanol degradation I phosphate ethanol phosphate 3- -D-ribofuranose activase: nrdG plsC synthase: N-acetyl-β-D- protein) protein] carrying ZapA aroA ile L-histidinol-phosphate pentose phosphate pathway UDP-N-acetylmuramoyl- fre HypE-S- synthase: 5-enolpyruvyl- [+ 3 isozymes] 6-carboxy-5,6,7,8- dehydrogenase: adhE hydrolase: dehydrogenase: epimerase: L-ribulose 5- 2-methylthio-N 6 - a c-type fabB fabB acetate glucosaminyl- met a peptide reductase: a disulfide bond DedD 3-isopropylmalate 4-hydroxy- homoserine dehydrogenase: β-D-glucose 6-phosphate L-alanyl-D-γ- D-arabinose β-D-galactose an alcohol a carboxylate β a [protein] C- carboxamide chorismate aroC 1-hydroxy-2-methyl- isopentenyl- β-D-glucose α-D-glucose phosphate 5'-deoxyadenosine 37 an unsulfurated a CcmH- a c-type a (6Z)-3-oxooctadec- a (7Z)-3-oxohexacos- a proteinogenic β -D-glucose acetaldehyde ADP a glutamine FlgJ YfcV shikimate 3- asd tetrahydropterin ethanol β D-xylopyranose treC adhE alsE dimethylallyladenosine met an active cytochrome dipalmitoyl a peptide -D-glucose gly (1->4)-D- terminal α-L- ECB_04076 dehydrogenase: tetrahydrodipicolinate dehydrogenase: metL histidinol- 2-(E)-butenyl diphosphate:NAD(P)+ -D-glucose [sulfur carrier] CcmG disulfide cytochrome glutamyl-meso-2,6- 6-enoyl-[acp] 7-enoyl-[acp] amino acid 6-phosphate a (6Z)-3- synthetase D-alanine xylose 5'-deoxyadenosine + glucosamine α gln phosphate dehydrogenase: adhP glucose-6-phosphate ethanol glucokinase: L-ribulose-5- in tRNA met ribonucleoside biogenesis phosphatidate FMN NADPH H glutamate- - oxooctadec- chorismate leuB synthase: dapA homoserine phosphatase: hisB L-aspartate- 4-diphosphate oxidoreductase: ispH 6-phosphate β-D-glucose F6P diaminopimeloyl- a cis-delta15-3- a cis-delta11-3- chorismate anthranilate chorismate isomerase: pgi isomerase: D-glucopyranose dehydrogenase: α-D-ribofuranose phosphate 4- triphosphate protein CcmE L-glutamate semialdehyde ethanol + glk D-alanine 6-enoyl-[acp] synthase: 3-isopropylmalate dehydrogenase: thrA NADP -dependent xylA 6-phosphate epimerase: reductase oxo-C34:1-[acp] oxo-C30:1-[acp] mutase: pheA synthase: (2S,4S)-4-hydroxy-2,3,4,5- histidinol adhP β YijD anthranilate aroC dehydrogenase homoserine IPP 7-carboxy-7- glucose-6- F6P D-xylulose -D-glucose ribokinase: araD OpgG ElfG NarX chorismate trpE trpD tetrahydrodipicolinate phosphate synthase: (decarboxylating) dehydrogenase: dimethylallyl- deazaguanine ethanol 6-phosphate rbsK [+ 2 isozymes] mutase: tyrA chorismate : dmlA 4-hydroxy- L-homoserine histidinol dehydrogenase: xylulokinase: UDP-N-acetyl-α-D-muramoyl-L- a reduced L-alanyl-γ-D- L-glycero-L-galacto- GDP-α-D- trpE trpD metL diphosphate:NAD(P)+ 7-cyano-7- 6-phosphofructokinase: 3-cis- + dehydrogenase: hisD selenocysteine biosynthesis I (bacteria) fructose 1,6- D-glucopyranose chitobiose degradation α-D-ribose D-xylulose ATP 2-N-acetamidomethylphosphonate γ 1-palmitoylglycerol ATP methylphosphonate a (7Z)-hexacos- an acyl-[acyl- a cis-delta19- acetyl-CoA L-cysteinyl-glycine NAD FADH 4-hydroxy- a ubiquitin C- D-gluconate L-lactaldehyde ADP ATP 2'-AMP anthranilate tetrahydrodipicolinate isopentenyl- deazaguanine zwf xylB D-arabinose alanyl- -D-glutamyl-meso-2,6- a palmitoleoyl-[acp] + + ferredoxin [iron- a malonyl-[acp] a malonyl-[acp] a malonyl-[acp] dodecenoyl-CoA glutamyl-meso- a type IV prepilin ThiS 2 octuluronate mannose S-sulfo-L-cysteine 5'Ap3A (2S)-2-isopropyl- homoserine oxidoreductase: ispH pfkB 6-phosphate 5-phosphate 5-phosphate 3-phosphate NADP H 7-enoyl-[acp] carrier protein] C38:1-[acp] ATP L-threonine terminal thioester chorismate ∆ bisphosphatase: ybhA diaminopimeloyl-D-alanyl-D-alanine sulfur] cluster diaminopimelate D-gluconate 5- NADP + - prephenate 3-oxosuccinate reductase: dapB diphosphate - synthase: queC Other 6-phospho 6-phosphofructokinase: D-xylulose N,N'-diacetylchitobiose degradation II 1-phosphate anthranilate anthranilate mutase: pheA homoserine O- homoserine histidinal dehydrogenase: [+ 3 isozymes] dehydrogenase: YraP YdeS sec isomerase: idi D-glucono- 5-phosphate dependent GDP- YjjP (S)-2,3,4,5-tetrahydrodipicolinate succinyltransferase: kinase: thrB thrA tRNA ser pfkA 6'-phosphate α-D-ribose-1-(2-N- α-D-ribose 1- 3-ketoacyl- cysteinylglycine flavin:NADH Ap A YicG phosphoribosyl chorismate preQ 1,5-lactone lactose degradation III chitin D-arabinopyranose β β kduD aldehyde 3 anthranilate selenide 0 muramoylpentapeptide acyl-[acp]:1-acyl- ferredoxin- -ketoacyl -ketoacyl β-ketoacyl murein leader ThiS L-glycero- 4-hydroxy- mannose S-sulfo-L- prephenate prephenate transferase: trpD mutase: tyrA metA histidinal aspartate D-mannose disaccharide D-arabinose acetamidomethylphosphonate) methylphosphonate CoA dipeptidase: pepA reductase: deubiquitinase: synthetase: 6-phosphogluconolactonase: fructose 1,6-bisphosphate carboxypeptidase: dacA sn-glycerol-3- NADP + [acyl-carrier [acyl-carrier [acyl- tripeptide peptidase: adenylyltransferase: L-galacto- L-threonine 5-keto-D- reductase: hydrolase: cysteine dehydratase: dehydrogenase: phosphoribosyl tetrahydrodipicolinate cys dehydrogenase: hisD L-homoserine DMAPP degradation II fructose bisphosphate isomerase: melibiose degradation -5-triphosphate synthase: 5-triphosphate thiolase: [+ 3 isozymes] hpaC elaD lysU N-(5-phosphoribosyl) 4-methyl-2- L-serine:tRNASec selenide, pgl degradation α-lactose N-monoacetylchitobiosedeacetylase: chbG trehalose degradation phosphate 2-O- reductase: protein] protein] carrier amidase: gspO thiF octuluronate- aldolase: gluconate 5- ybbO nudK reductase: pheA tyrA transferase: trpD prephenate succinylase: dapD O-phospho-L-homoserine aldolase: fbaB fucI phnL phnH phnG phnI muramoyl pentapeptide synthase: phnL fadA adenosine -anthranilate oxopentanoate α VI (periplasmic) acyltransferase: synthase: fabB mpaA FAD 1-phosphate ltaE reductase: [+ 3 isozymes] grxA Ivy ElfA N-(5-phosphoribosyl) O-succinyl-L-homoserine homoserine O- ligase (AMP- water D-gluconate DHAP -D-mannose 6'-phosphate D-ribulose carboxypeptidase: dacC phnH phnG phnI fpr synthase: fabB protein] his asp fructose bisphosphate melibiose acetyl-CoA C- reductase: fre idnO (S)-propane- phosphoribosylanthranilate prephenate leucine N-succinyl-2-amino-6-ketopimelate succinyltransferase: forming): serS dikinase: 6-phosphate monoacetylchitobiose- α α α plsC synthase: an N-terminal aldolase: ydjI α ADP YjcH 2-oxo-3- -anthranilate threonine aspartate 6-phosphate aldolase: fbaA mannose-6- lactose , -trehalose -D-ribose 1- acyltransferase: cys gly a thiol 5-dehydro- 1,2-diol -D-mannose 5'Ap3A AMP RsxA 4-hydroxyphenylpyruvate isomerase: trpC dehydratase: aminotransferase: metA selD fabB L-phenylalanyl- a peptide ThiS-COAMP a ubiquitin phenylpropanoate synthase: thrC triose-phosphate phosphate galactohydrolase: 6-phosphate (acetamidomethylphosphonate) UDP-N-acetylmuramoyl-L- α an oxidized L-alanyl-D- 1-phosphate phosphoribosylanthranilate pheA tyrB N-succinyldiaminopimelate transaminase: 6-phosphogluconate adenine -D-ribose-1- a (9Z)-3-oxooctacos- fadI meso- glycolaldehyde D-gluconate GMP sulfite 1-(o- O-succinylhomoserine(thiol) an L-seryl- hydrolase: chbF α-galactosidase: γ ferredoxin [iron- a 3-oxoacyl-[acp] [type IV prepilin] + gly O-succinyl-L- aspC dehydrogenase, isomerase: tpiA isomerase: lacZ 5-triphosphate D-alanine alanyl-D- -glutamyl-meso-2,6- methylphosphonate- NADPH glutamate FAD NADH H aldehydo-L- cys tyrosine isomerase: trpC aminotransferase: argD -lyase: metB cys sec selenophosphate Tetrapyrrole Biosynthesis trehalase: treF 1-palmitoyl-2-palmitoleoyl- adenine 9-enoyl-[acp] diaminopimelate DHAP carboxyphenylamino) 2-oxo-3- leucine homoserine [tRNA ] oxaloacetate manA N-acetyl-D-glucosamine D-ribulose melA diaminopimeloyl-D-alanine sulfur] cluster arabinuronate RseB aminotransferase: 1-(o- N-succinyldiaminopimelate thr decarboxylating: gnd sn-glycerol 3-phosphate 5-triphosphate a cis-delta21-3- -1'-deoxyribulose phenylpropanoate transaminase: β β 6-phosphate 5-phosphate 3-keto-5-cis- aspC D-ribulose F6P -D-galactose -D-glucose oxo-C40:1-[acp] 5'-phosphate carboxyphenylamino) ilvE aminotransferase: serC ammonia tetrapyrrole biosynthesis malate D-glyceraldehyde 3-phosphate α-D-galactose β-D-glucose α-D-glucose β-D-glucose tetradecenoyl-CoA thiamin YgdR serine biosynthesis L-cystathionine O-succinylhomoserine(thiol) selenocysteine siroheme biosynthesis 5-phosphate phe tyrosine indole-3- -1'-deoxyribulose uracil assimilation cycle III I (from glutamate) superpathway of heme biosynthesis from uroporphyrinogen-III dehydrogenase: fructose degradation triphosphate N-succinyl-L,L-2,6-diaminopimelate -lyase: metB synthase: selA glyceraldehyde- + + aminotransferase: 5'-phosphate leu mdh H H glycerol degradation α synthase / tyrB indole-3- 3-phospho- cystathionine ribulose- 3-phosphate β-D-fructofuranose a [ribosomal bis(guanylyl a [ThiI sulfur- a [prolipoprotein]- a [protein chain microcin B17 precursor GDP- -D- a mismatched YhjJ phosphate I (reductive) succinyl- glt an L- uroporphyrinogen-III uroporphyrinogen-III ribose-5- a sulfurated a [disordered-form [Fe-S] an S-sulfanyl-[L- a uracil in DNA (I) a holo-[EntB aryl- bis-MGD cofactor a cis-delta11- acetate butanoyl-CoA a cis,cis-delta11,29-3- oxalate acetyl-CoA a ribonucleoside an oligopeptide D-lactaldehyde glyoxylate ATP synthase phe D-glycerate β-lyase: malY ammonium glt (S)-malate dehydrogenase: gapA protein S12] 2,3- molybdopterin) cys carrier protein]- S-1,2-diacyl-sn- a malonyl-[acp] D-β-lysine elongation factor a tRNA precursor a lipoyl-[acp] peptide containing D-tyrosyl-tRNA Tyr SucB lipoyl-ACP mannose 3'-GMP synthase: trpC glycerol uracil D-3- diaminopimelate selenocysteinyl- S-adenosyl-L- phosphate 3- phosphate 1-phosphate cluster scaffold protein] cysteine desulfurase] carrier protein] chaperone C30:1-[acp] hydroxy C48:2-[acp] Apo-GcvH diphosphate DNA base pair cystathionine L-cystathionine 1-phosphofructokinase: Detoxification [sulfur carrier] L-aspartate 89 dihydroxybenzoate cofactor L-cysteine glyceryl-L-cysteine 34 azole residues NADP + - glyoxylate tyr phosphate phosphoglycerate sec glutamate--tRNA methionine:uroporphyrinogen- epimerase: isomerase P]-L-lysine 3-oxoacyl-[ACP] ribonucleoside- methyl- MzrA (1S,2R)-1-C-(indol-3- desuccinylase: dapE β [tRNA ] uroporphyrinogen 13-DPG fruK thiamin synthase: trpC -lyase: metC ligase: gltX III C-methyltransferase: cysG rpe A: rpiA fructose 1,6- reductase: fabG diphosphate dependent GDP- directed reductase: yl)glycerol 3-phosphate dehydrogenase: serA glutamine cystathionine decarboxylase: hemE bifunctional fused predicted acetyl- peptidyl- triphosphate 3-phospho- Glu superoxide aldehyde mismatch ghrB + + β an L-glutamyl-[tRNA ] precorrin-1 phosphoglycerate bisphosphate protein scaffold 2,3- bis-MGD cysteine prolipoprotein β-ketoacyl EF-P-lysine 3-ketoacyl-(acyl- reductase: microcin B17 Tyr mannose H H ApaG (1S,2R)-1-C-(indol-3- 5,6-dihydrouracil hydroxypyruvate L,L-diaminopimelate L-homocysteine synthetase: glnA -lyase: malY ribose-5- arsenate uracil DNA acetyl- RNase D lipoyl-protein CoA:oxalate D-Tyr-tRNA dipeptidase: lipoyl-protein synthase / D-xylulose radicals arginine dependent methylthiotransferase: protein for iron- dihydroxybenzoate- cofactor desulfurase: signal lysyltransferase: carrier-protein) nrdE nrdF precursor reductase: mannosyl repair: glyoxylate yl)glycerol 3-phosphate cystathionine coproporphyrinogen III phosphate kinase: pgk detoxification glycosylase [acyl- CoA:acetoacetyl- exonuclease: rnd ligase: lipB CoA- deacylase: dtd dcp ligase: lipB ATP synthase indoleglycerol 3-phosphoserine S-adenosyl-L- sedoheptulose 5-phosphate degradation acid resistance rimO sulfur cluster [aryl-carrier chaperone: iscS peptidase: lspA epmA reductase: protease: ybbO hydrolase: mutL reductase: indoleglycerol diaminopimelate β-lyase: metC glutamyl-tRNA isomerase: II (glutaredoxin) (G:U carrier CoA transferase: transferase: ribonucleoside- guanosine phosphate aminotransferase: cobalamin- gln methionine:precorrin-1 C- bisphosphate bypass 3-phospho-D-glycerate assembly: iscU tldE tldD [+ 3 isozymes] mutH mutS ghrA glutamate biosynthesis III epimerase: dapF reductase: hemA rpiB superoxide specific): nth protein] ligase: entE fdhD protein] α β ECB_04076 yfdE diphosphate gmm a properly + + MscM aldolase: trpA phosphate serC independent methionine coproporphyrinogen coproporphyrinogen III methyltransferase: cysG heme biosynthesis arsenate subunit/ a [glycine-cleavage (R)-propane- H PntAB H D-sedoheptulose superoxide arg a [ThiI sulfur- an (S-diacyl- synthase: a cis,cis-delta11,29- a dipeptide glycolate aldolase: trpA L-amino acid synthase: metH L-homocysteine a [ribosomal a lipoprotein subunit: ydiF [a protein chain a nucleoside 5'- 6 reductase: a peptide matched OpgD ser homocysteine L-glutamate:NADP+ III oxidase: hemF dehydrogenase: hemN from uroporphyrinogen- 2,3-bisphosphoglycerate- arsenate an unsulfurated a tRNA 3-oxo-C48:2-[acp] complex H protein] N D-tyrosine a tRNA Tyr 1,2-diol SucB-lipoate 3-ureidopropionate 3-phospho- exporter: lysO glutamate-1-semialdehyde precorrin-2 7-phosphate D-ribose 5- dismutase: arginine 5'-deoxyadenosine met protein S12]-3- an S-sulfanyl-[cysteine α β a 2,3- [bis-MGD cofactor ala carrier protein]- sn-glyceryl) signal peptide fabB elongation factor monophosphate nrdB nrdA DNA base pair 2-oxoglutarate transmethylase: metE III I (aerobic) phosphoglycerate reductase: [sulfur carrier] a 5'-phospho- a [DNA]-3'- , - uracil -[(R)-lipoyl]-L-lysine a 2'- microcin B17 D-mannose indole indole ser L-serine oxidoreductase cobalamin- sedoheptulose- phosphate independent sodB decarboxylase, methylsulfanyl- desulfurase]-[disordered-form dihydroxybenzoyl- chaperone]- S-sulfanyl- -L-cysteinyl- EF-P]-N-(β-L- acetate oxalyl-CoA a peptide GDP L-glutamate:NADP+ glutamate-1- mutase: gpmA arsC unsaturated deoxyribonucleoside (transaminating) methionine protoporphyrinogen IX protoporphyrinogen IX uroporphyrinogen-III phosphoglycerate Carboxylate Degradation degradative: adiA 89 [DNA] L-cysteine [apolipoprotein] 34 oxidoreductase phosphoserine meso-diaminopimelate independent precorrin-2 7-phosphate L-ascorbate superoxide L-aspartate scaffold protein] complex aldehyde [EntB aryl- bis-MGD acetyl-CoA n-butanoate lysyl)-L-lysine 5'-diphosphate tyr TyrP tyr met : gltD gltB semialdehyde 2,1- transketolase: mutase: gpmM superpathway of hexuronide ketogluconate metabolism L-ascorbate arsenite agmatine a cis-delta13-3- 03552 (deaminating): gltD gltB synthase: homocysteine dehydrogenase: cysG uroporphyrinogen kinase: pfkA degradation II dismutase: carrier protein] tryptophan tryptophan phosphatase: aminomutase: hemL tktB and hexuronate degradation degradation I oxo-C32:1-[acp] YahO diaminopimelate metH transmethylase: decarboxylase: hemE (bacterial, aerobic) sodA glutamate synthase: trpB synthase: trpB serB glt protoporphyrinogen D-sedoheptulose- transketolase: 2-phospho-D-glycerate a β-D- 2,5-didehydro- (bacterial, anaerobic) β-alanine decarboxylase: lysA metE 5-amino-levulinate sirohydrochlorin coproporphyrinogen III hydrogen tyr tyr dehydrogenase: gdhA dehydrogenase: hemG 1,7-bisphosphate tktA L-ascorbate glucuronoside D-gluconate L-ascorbate AroP ser peroxide phe phe glt enolase: eno β 6-phosphate peptidoglycan a 5'-phospho- porphobilinogen sirohydrochlorin coproporphyrinogen D-sedoheptulose D-glyceraldehyde -D- catalase: an [RNA]-3'- a nascent peptidoglycan 3-oxo-(7Z)- a thymine a cis,cis-delta13,31-3- a cis,cis-delta17,29- phosphoenol trp trp lys met sedoheptulose 2,5-diketo- L-ascorbate- a 2,3,4-saturated 2- a 2,3,4-saturated a cis-delta15- an ADP-sugar 2,3- a (3R)-3- ribonucleoside- citrate H O ATP an mRNA HMP-PP L-threonine 3- ferrochelatase: cysG glucuronidase: ribonucleoside- gly with (L-alanyl-γ-D-glutamyl- MlpA tetrapeptide, tetradecenoyl-CoA glycol in DNA a malonyl-[acp] ser 3-sulfinoalanine ATP L-selenocysteine pyruvate 2 AceF lipoyl-ACP a protein synthase: hemB III oxidase: hemF bisphosphate 7-phosphate 3-phosphate L-dehydro- 6-phosphate adeD GTP dGTP fatty acyl-[acp] C34:1-[acp] hydroxydocosanoyl-[acp] hydroxy C50:2-[acp] 3-hydroxyC48:2-[acp] xanthosine O-phosphate PspD ElfD uidA D-gluconate a 5'-hydroxy- 2',3'- meso-2,6-diaminopimeloyl- lysophosphatidate glycan chain 1 dihydroxybenzoate 3-oxoacyl-[ACP] 3-oxoacyl-[ACP] 3-oxoacyl-[ACP] [RNA] HMP-PP protoporphyrin IX phosphoenolpyruvate lactonase: 2-methylcitrate cycle I [+ 2 isozymes] branched chain aldolase: fbaA ascorbate reductase: ribonucleotide- cyclophosphate D-alanine) tetrapeptide hydrolase: porphobilinogen siroheme protoporphyrinogen IX transaldolase: ulaG ADP-sugar reductase: fabG reductase: fabG reductase: fabG poly(A) amino acid / D-glucopyranuronate dkgB 2-keto-D-gluconate O 3'-[RNA] 3-ketoacyl-CoA bifunctional citrate lyase cof ferrochelatase: hemH 3-keto-L-gulonate 2 L,D- β enterobactin RNA 5' phe phe D-erythrose talB phosphoenolpyruvate pyruvate kinase: pykF acyl-[acp]:1-acyl- L,D- thiolase: fadA thymine -ketoacyl diphosphatase: 3-ketoacyl-(acyl- 3-ketoacyl-(acyl- 3-ketoacyl-(acyl- cysteine sulfinate selenocysteine citrate lyase: lipoyl-protein polymerase: phenylalanine hydroxymethylbilane DHAP 2,5-diketo- 6-phosphate propanoate xanthosine HMP-PP [+ 2 isozymes] 4-phosphate transaldolase synthetase: ppsA pyruvate kinase: pykA RNA transpeptidase: dGTP sn-glycerol-3- transpeptidase: glycol DNA [acyl- nudE synthase: carrier-protein) carrier-protein) carrier-protein) desulfinase: sufS adenylyl lyase: sufS citD citE citF ligase: lipB pcnB ABC transporter synthase: hemC D-gluconate acetyl-CoA C- nucleosidase: hydrolase: LolA Aminoacyl-tRNA Charging A: talA dehydroascorbate 3-keto-L- ligase: rtcB ldtD triphosphohydrolase: dgt phosphate 2-O- ldtC glycosylase: carrier ADP-sugar entE entF reductase: reductase: reductase: cysteine sulfinate transferase: thr protoheme IX reductase: propanoate:CoA acyltransferase: rihC nudJ ElyC pyruvate (bicyclic form) acyltransferase: nth protein] entD entB ECB_04076 ECB_04076 ECB_04076 desulfinase: csdA rtcA leucine / L- hydroxymethylbilane protoporphyrin IX gulonate-6- ligase (AMP- fadI pyrophosphatase: aldehydo-D- aldehydo-D- dkgA a nascent peptidoglycan plsC a peptidoglycan synthase: a cis,cis-delta13,31- a cis,cis-delta17,29- pyruvate an mRNA HMP-P phe phenylalanine phe tRNA charging D-erythrose phosphate forming): acs nudF a 3-oxodocosanoyl-[acp] selenide acetate oxaloacetate F6P pyruvate galacturonate glucuronate 2,5-diketo- γ fabB 3-oxo-C50:2-[acp] 3-oxo-C48:2-[acp] a 5'-(5'- ala AceF-lipoate arg a peptide ABC transporter ferrochelatase: hemH 4-phosphate decarboxylase: [+ 4 isozymes] with (L-alanyl- -D-glutamyl- D-alanine PPP tripeptide D-alanine D-ribofuranose uroporphyrinogen- dehydrogenase: D-gluconate GMP i an apyrimidinic enterobactin xanthine D-galacturonate D-glucuronate sgbH a ligated RNA meso-2,6-diaminopimeloyl- 2'-deoxyguanosine crosslinked to thymine glycol sulfite diphosphoadenosine)- LolB III synthase: hemD [+ 2 isozymes] transketolase: lpd aceF aceE 2,3-dioxo- reductase: 2-keto-L-gulonate 2-keto-D- a 2,3,4-saturated 1,2-diacyl- acetyl-CoA (5Z)-dodecenoyl-CoA site in DNA an α-D-aldose ala Gly Phe ser Asn Tyr Thr asp Arg Ile Met glu His Ala Lys Trp Pro Cys Leu Gln isomerase: glycine) tetrapeptide lipopolysaccharide AMP (ribonucleoside)-[RNA] phe PheP phe gly a tRNA phe a tRNA ser a tRNA asn tRNA tyr a tRNA thr a tRNA tRNA asp arg a tRNA ile a tRNA met a tRNA glt a tRNA his a tRNA a tRNA ala lys a tRNA trp a tRNA pro a tRNA cys a tRNA leu a tRNA gln a tRNA tktB isomerase: uxaC gluconate 3-keto-L- propanoyl-CoA 1-phosphate val Val L-gulonate uxaC ghrB sn-glycerol 3-phosphate a cis-delta17-3- a tRNA uroporphyrinogen-III protoheme IX transketolase: acetyl-CoA 2-keto-L- reductase: YohD 2,3-diketo- D-tagaturonate gulonate-6- 2-methylcitrate oxo-C36:1-[acp] tktA D-fructuronate gulonate ghrB phosphate asparagine--tRNA oxaloacetate L-gulonate synthase: prpC glycine--tRNA phenylalanine--tRNA L-serine:tRNASer ligase tyrosyl-tRNA threonine--tRNA aspartate--tRNA arginine--tRNA isoleucine--tRNA methionine--tRNA glutamate--tRNA histidine--tRNA alanine--tRNA lysine--tRNA ligase: lysS tryptophan--tRNA proline--tRNA cysteine--tRNA leucine--tRNA glutamine--tRNA D-glyceraldehyde tagaturonate reductase: decarboxylase: FlgA ligase: asnS valine--tRNA ligase: valS reductase: YhdV ligase: glyQ glyS ligase: pheS pheT (AMP-forming): serS synthetase: tyrS ligase: thrS ligase: aspS ligase: argS ligase: ileS ligase: metG ligase: gltX ligase: hisS ligase: alaS lysine--tRNA ligase: lysU ligase: trpS ligase: proS ligase: cysS ligase: leuS ligase: glnS 3-phosphate reductase: D-mannonate ghrB ulaD (2S,3S)-2- citrate synthase: gltA yiaK a pyrimidine base di-trans,octa-cis an apo-[c-type 5-amino-6-(5-phospho- 3-oxo-(11Z)- an O-acetyl- an insertion (S)-3- oxidoreductase: UDP-α-D-glucose an adenosine 37 a cis-delta17- a cis,cis-delta15,33-3- a cis,cis-delta21,39- a D-aminoacyl- formate uxaB L-idonate L-xylulose - methylcitrate a 5'-hydroxy- -undecaprenyl F6P cytochrome] a CcmH protein DMAPP a malonyl-[acp] a peptide a RNA-DNA hybrid GlnK Apo-GcvH (R)-lipoate ADP-ribose sequence AceF hydroxybutanoyl- FMN a protein creatine- uxuB lesion in DNA an [RNA]-3'- GTP D-ribosylamino)uracil in tRNA C36:1-[acp] octadecenoyl-CoA hydroxy C52:2-[acp] 3-hydroxyC58:2-[acp] [tRNA] (R)-lipoate Gly Phe ser Asn Tyr Thr asp Arg Ile Met Glu His Ala Lys Trp Pro Val Cys Leu Gln 3-keto-L-gulonate 2-methylcitrate ribonucleotide- phosphate UTP FMN phosphate LdrD a glycyl-[tRNA ] an L-phenylalanyl-[tRNA ] an L-seryl-[tRNA ] an L-asparaginyl-[tRNA ] an L-tyrosyl-[tRNA ] an L-threonyl-[tRNA ] an L-aspartyl-[tRNA ] an L-arginyl-[tRNA ] an L-isoleucyl-[tRNA ] an L-methionyl-[elongator tRNA ] an L-glutamyl-[tRNA ] an L-histidyl-[tRNA ] an L-alanyl-[tRNA ] an L-lysyl-[tRNA ] an L-tryptophanyl-[tRNA ] an L-prolyl-[tRNA ] an L-valyl-[tRNA ] an L-cysteinyl-[tRNA ] an L-leucyl-[tRNA ] an L-glutaminyl-[tRNA ] D-altronate 5-phosphate ribonucleoside- with reduced L- with an internal 3-oxoacyl-[ACP] 3-oxoacyl-[ACP] element IS30putative CoA enoyl-CoA ATP- acetyl-CoA malate:quinone malate L-idonate 5- dehydratase: 3'-[RNA] D-mannonate 3'-phosphate cysteine residues disulfide bridge reductase: fabG reductase: fabG 2''-O-acetyl- transposase: phosphatase: dependent YceI oxidoreductase: dehydrogenase:mqo mdh 3-keto-L- dehydrogenase: putative L- bifunctional fructose-6- 5-amino-6-(D- 3-ketoacyl-CoA lipoate-apo- formate hydratase: prpD UDP- tRNA β proline RNase: rnhB [protein-PII 2] D-aminoacyl- ybjI YnfM gulonate D-altronate idnD xylulose 5- DNA 3'-PO4/5'- phosphate ribitylamino) -ketoacyl thiolase: fadA 3-ketoacyl-(acyl- 3-ketoacyl-(acyl- GcvH protein ADP-ribose dehydrogenase: yhhI-1 lipoate-AceF fadB HslVU cis-2- glucose:undecaprenyl- dimethylallyltransferase: aminopeptidase: ribonuclease: rnhA uridylyltransferase: tRNA FMN (S)-malate citrate kinase: dehydratase: D-mannonate phosphate 3- glycosylase: OH RNA aldolase: fsaA thiol:disulfide uracil [acyl- carrier-protein) carrier-protein) ligase: lplA deacetylase: fdhF an insertion[+ 3 isozymes] ligase: lplA enoyl-CoA protease: malate synthase G: glcB methylaconitate phosphate glucose- miaA acetyl-CoA C- pepP glnD deacylase: phosphatase: lyxK uxaA dehydratase: 5-dehydro-D-gluconate epimerase: nei ligase: rtcB oxidoreductase: glycosidase: carrier reductase: reductase: ymdB sequence IS30 hydratase: hslV hslU creatine malate synthase A: aceB (2R,3S)-2- 1-phosphate fructose-6- acyltransferase: yigB uxuA sgbU ccmH ybiA protein] ECB_04076 ECB_04076 dtd with integrated fadJ a peptide YabI YjfN Carbohydrate Biosynthesis phosphate 6 fadI a nucleoside 5'- a [glycine-cleavage citrate hydro-lyase: acnB 3-keto-L-gulonate methylisocitrate transferase: wcaJ N -(3-methylbut- synthase: DNA a cis,cis-delta15,33- a cis,cis-delta21,39- CO A(H2) riboflavin L-xylulose 5- a [DNA]- aldolase: fsaB complex H protein] N 6 2 transposon crotonyl-CoA peptidoglycan biosynthesis I (meso-diaminopimelate containing) Cell Structure Biosynthesis 6-phosphate 5-keto-D- hydro-lyase: acnB a 5'-phospho- a modified 2-en-1-yl)- fabB a proteinogenic monophosphate 3-oxo-C52:2-[acp] 3-oxo-C58:2-[acp] acetate ADP-D-ribose AceF-lipoate YbjO palmitate biosynthesis Fatty Acid and Lipid Biosynthesis citrate hydro-lyase (cis- phosphate 3- nucleotide- 4-oxo-2-pentenal GMP an apo-[c-type a peptide uridylyl-[GlnK] -[(R)-lipoyl]-L-lysine superpathway of lipopolysaccharide biosynthesis stearate biosynthesis gluconeogenesis I aconitate-forming): acnA 3-keto-L- gluconate 5- (2R,3S)-2- [DNA] nucleobase RNA α D-ribofuranose adenosine 37 amino acid a tRNA II (bacteria and plants) PRPP biosynthesis II O-antigen building blocks biosynthesis (E. coli) ADP-L-glycero-β-D-manno galactose degradation I (Leloir pathway) trehalose biosynthesis I UDP-N-acetyl- fumarase C: fumC epimerase: 3'-phosphate -D-glucopyranosyl- UMP cytochrome]-- 5,6-diaminouracil acetyl-CoA palmitoleoyl-CoA a D-amino acid II (bacteria and plants) reductase: methylisocitrate D-glyceraldehyde 5-phosphate in tRNA -heptose biosynthesis α [+ 4 isozymes] gulonate-6- superpathway of D-glucarate ulaE diphosphoundecaprenol dihydroxyacetone CcmH disulfide EfeO a (3R)-3- α -D-glucosamine 2-dehydro- 3-phosphate a cis-delta19-3- (S)-malate UDP- -D- α-D-glucose β-D-glucose α fumarate cis-aconitate phosphate and D-galactarate degradation idnO an acetoacetyl-[acp] hydroxytetradecanoyl- D-ribose 5- D-sedoheptulose β-D-galactose -D-glucose UDP-N-acetylglucosamine 3-deoxy-D- L-ribulose 5- YbjJ UDP-N-acetyl- a palmitoyl-[acp] galactose 1-phosphate 6-phosphate UDP-α-D-glucose decarboxylase: 2-methylisocitrate oxo-C38:1-[acp] [acp] α-D-glucosamine phosphateα 7-phosphate 6-phosphate 1-carboxyvinyltransferase: D-threo-isocitrate gluconate phosphate acetoacetyl-[acp] malate -D-ribose 1,5- glucose-6- D-sedoheptulose galactose-1- Respiration respiration (anaerobic) glyoxylate sgbH D-glucarate D-galactarate lyase: prpB YidD dTDP-glucose α murA succinate:quinone hydro-lyase: acnB 2-dehydro-3- L-ribulose-5- reductase: fabG dehydrogenase, phosphomutase: phosphate 7-phosphate epimerase: -D-glucose acyl-[acyl-carrier- superpathway of (KDO) -lipid A biosynthesis pyrophosphorylase: trehalose-6- UDP-N-acetyl-α- oxidoreductase: sdhA 3-keto-L- deoxygluconokinase: phosphate 4- a 5- a [50S ribosomal (Z)-2- GMP-N-ε-(N-α-acetyl α-D-ribose-1- a protein 2 a 3-oxooctadecanoyl- NAD-requiring: α deoB isomerase: gmhA galM 1-phosphate D-threo-isocitrate carboxy-S- 3-oxo-(9Z)- peptidoglycan D- RNase II poly-A hydrogen (2E,5Z)- guanosine 2'- PqiC -D-ribose- UDP-Galf isomerase: D-glycero-D- phosphate 2-phospho-D-glycerate gulonate-6- D-glucarate pyruvate succinate 34 Reactive Blue 5 2-oxoglutarate a peptide with a an alkylsulfonate a cis,cis-delta19,37-3- a cis,cis-delta17,35- a uridylylated N-methyl-L- a reduced an acetic ester ATP biotin 3-ketoacyl-(acyl- protein]--UDP-N- malate rfbA D-glucosamine- sdhD sdhC sdhB hydro-lyase (cis- kdgK galactarate epimerase: adenosyl-L- hydroxyuridine YhaS SAM subunit protein methylureidoacrylate lysine methyl ester) methylphosphonate a 3-oxoacyl-[acp] SucB dodecenoyl-CoA with incorrect [acp] maeA 1-phosphate pgi hexadecenoyl-CoA alanyl-DAP crosslink leader sequence hydroxy-C56:2-[acp] 3-hydroxyC54:2-[acp] PII protein tryptophan substrate mRNA peroxide thioredoxin (R)-lipoate monophosphate carrier-protein) acetylglucosamine O- a (3R)-3- dehydrogenase: manno-heptose α synthase: otsA phosphate dehydratase: dehydratase: 81 5'-phosphoramidate 5-phosphate enoyl-CoA dTDP-glucose -D-galactose UTP--glucose- enolpyruvate aconitate-forming): acnA D-gluconate araD D-galactonate degradation methionine in tRNA L16]-L-arginine peracid 3-oxoacyl-[ACP] 3-oxoacyl-[ACP] 3-ketoacyl- disulfide bonds MdtD reductase: acyltransferase: lpxA hydroxytetradecanoyl- UDP-N-acetyl- 3-oxoacyl- mdh pyrophosphorylase: 7-phosphate isocitrate lyase: aceA decarboxylase: KDGP gudD garD hydratase: D-ribulose F6P heptose 7- 1-phosphate α α UDP-N- enolase: eno [+ 2 isozymes] reductase: fabG reductase: fabG (acyl-carrier- YidI ECB_04076 [acp] α-D-glucosamine [ACP] , -trehalose succinate ulaD dye- protein- 3-ketoacyl-CoA meso- alkanesulfonate exoribonuclease acetylesterase: fadB biotin-ATP 5-phosphate rffH galactokinase: uridylyltransferase: acetylenolpyruvoylglucosamine D-threo-isocitrate D-gluconate D-xylulose D-galactonate tRNA U34 pyruvate (Z)-2- purine nucleoside leader carbon- 3-ketoacyl-(acyl- 3-ketoacyl-(acyl- PII-UMP N-methyl-L- protein) UDP-3-O-[(3R)-3- phosphate 6-phosphate 5-dehydro-4- decolorizing thiolase: fadA diaminopimelic monooxygenase: lipoate-SucB YdhX a (3R)-3- reductase: malate α L-glutamine--D- galK galU reductase: murB isocitrate L-xylulose - kinase: gntK 5-phosphate arginine phosphoramidase: peptidase: phosphorous deuridylylation: tryptophan II: rnb aes enoyl-CoA ligase: birA hydroxymyristoyl]- acyl-[acyl-carrier- D-arabinose -D-ribose 1,5- dTDP-α-D-glucose kinase: hldE phosphoenolpyruvate 2-keto-3- carboxymethyltransferase: peroxidase: formate-lyase methylureidoacrylate ssuD carrier-protein) carrier-protein) reductase: ligase: lplA a protein D-ribulose fabG fructose-6- β trehalose-6- ala α succinate 5-phosphate deoxy-D-glucarate D-gluconate D-galactonate oxygenase: acetyl-CoA C- acid-D-alanyl hydroxybutanoyl-[acp] α 5-phosphate dehydrogenase: bisphosphate D-glycero- -D- α UDP-N- -D- succinyl-CoA dehydrogenase: icd deoxygluconate cmoB activating peracid hinT lepB lyase: phnJ reductase: reductase: glnD oxidase: solA a (3R)-3-ECB_04076 hydratase: with correct 5-phosphate N-acetyl- -D- protein]--UDP-N- -D-galactose α-dehydro- dehydratase: yfeX roxA acyltransferase: endopeptidase: guanosine isomerase: 3-ketoacyl- oxaloacetate maeB dTDP- phosphate manno-heptose UDP-α-D-glucose phosphate acetylmuramate synthetase: sucD sucC putative L- kinase: idnK enzyme: pflA amidohydrolase: rutB ECB_04076 ECB_04076 RNase II fadJ disulfide bonds (3R)-3- glucosamine acetylglucosamine O- ribose 1,5- 1-phosphate 6-phosphate β fadI dacB hydroxyacyl-[acyl- (S)-3-hydroxy-(5Z) biotinyl-5'- SapA D-arabinose (acyl-carrier- glucose 4,6 aminotransferase: 1,7-bisphosphate phosphatase: glt pyruvate kinase: pykF phosphoenolpyruvate xylulose 5- -deoxy-D D-gluconate dgoD α a cis,cis-delta19,37- a cis,cis-delta17,35- AMP an oxidized H O acetate an alcohol UDP-3-O-acyl-N- gutQ aldolase: eda 5-phospho- - an aldehyde sulfite UMP substrate with 2 carrier protein] YqjE hydroxybutanoyl- acyltransferase: lpxA bisphosphate carboxylase: ppc a 5-(carboxymethoxy) 3-[(4-amino-6-chloro- a [50S ribosomal N-α-acetyl lysine [+ 3 isozymes] -dodecenoyl-CoA adenylate Eco 5-phosphate protein) dehydratase: glmS D-glycero- otsB UDP-N- pyruvate kinase: pykA phosphate 3- -glucarate 6-phosphate pyruvate fermentation 2-dehydro-3-deoxy- 2,2'-disulfonyl methane D-ribose 1,2- 3-oxo-C56:2-[acp] 3-oxo-C54:2-[acp] formaldehyde no poly-A tail thioredoxin SucB-lipoate [acyl-carrier acetylglucosamine D-arabinose pyruvate glutamate uridine 34 in tRNA SAH 1,3,5-triazin-2-yl) phthalate 2-ketobutyrate formate- succinate GMP a leader sequence a peptide a PII protein trp phosphoenol phosphokinase: rfbB β acetylmuramate--L- aldolase: garL D-galactonate azobenzene 5'-deoxyadenosine subunit protein L16]- carbamate (Z)-2-methyl- methyl ester isomerase: deacetylase: lpxC UDP-3-O-[(3R)-3- reductase: D-glucosamine -D-manno- α,α-trehalose epimerase: D-glyceraldehyde to acetate IV lyase / pyruvate cyclic phosphate protein] 5-phosphate pyruvate phnN alanine ligase: murC racemase: Hydrogen pyruvate amino]benzenesulfonate (3R)-3-hydroxy- acetyl-CoA (7Z)-tetradecenoyl-CoA peroxyaminoacrylate peptidoglycan peptidoglycan gutQ UDP-3-O-(3- hydroxymyristoyl]- ECB_04076 dTDP- 6-phosphate heptose-1,7- pyruvate oxaloacetate succinyl-CoA 2-oxoglutarate sgbU 3-phosphate 2-dehydro-3- dehydratase: fabZ isomerase: murI Production tartronate semialdehyde formate-lyase 4 81 a (3R)-3- carboxykinase phosphoenolpyruvate bisphosphate 7- L-arginine tetrapeptide, tetrapeptide, D-arabinose hydroxymyristoyl) N-acetyl-α-D- kdsD PRPP glucose 4,6- phosphoglucosamine L-xylulose 5- pyruvate deoxygalactonokinase: 3-hydroxyacyl- hydroxyoctadecanoyl- (ATP): pck synthetase: ppsA UDP-N- glycan chain 1 glycan chain 2 YaiY 5-phosphate -α-D-glucosamine glucosamine dehydratase: mutase: glmM phosphatase: malate hydrogen phosphate 3- tartronate dgoK HdeB YcaI [acp] D-arabinose [acp] acetylmuramoyl- D-glutamate pyruvate malonate isomerase: UDP-3-O-(3- UDP-3-O-acyl-N- rffG gmhB UDP-glucose:α- dehydrogenase: mdh production V epimerase: semialdehyde 2-dehydro-3-deoxy- dehydratase: fabA 5-phosphate D-glucosamine D-glycero-β-D- UDP- L-alanine dehydrogenase: degradation I kdsD hydroxymyristoyl) acetylglucosamine (3R)-3- phosphoenolpyruvate D-galactose- reductase: garR D-galactonate α-D-ribose-1-(2-N- a nascent peptidoglycan di-trans,octa-cis 1-myristoyl- an unstable a [protein disulfide 1-deoxy- dTDP-4-dehydro- 2-oxoglutarate ulaE (biotin-independent) lipid A-core 3-oxo-(7Z)- salicin 6- a cis,cis-delta19,31- a 5'-NAD- glucosamine N- 3-deoxy- hydroxyacyl- 1-phosphate manno-heptose glucose 4- lpd aceF aceE (S)-malate 6-phosphate acetamidomethylphosphonate) 1-cis-vaccenoyl-sn- thiosulfate pyruvate an alkylated DNA a [protein] Ser/Thr CDP-glycerol [DNA] RecA filament- a polypeptide O-phospho- D-arabinose deacetylase: lpxC 6-deoxy-α-D- 1-phosphate UDP-N- dehydrogenase: formate L-ribulose 5- [a holo malonate SAM (meso-DAP containing) a palmitoleoyl-[acp] -undecaprenyl hexadecenoyl-CoA O-acetyl-L-serine sn-glycerol a myristoyl-[acp] a PII protein phosphate capped-[RNA] L-allo-threonine isomerase] 2'-deoxyadenosine D-xylulose a (2E)-but-2-enoyl-[acp] UDP-3-O-(3- D-manno- [acyl-carrier 1-phosphate epimerase: formate D-glycerate glycerol-3-phosphate UTP dATP 3-hydroxyC50:2-[acp] 1-deoxy- L-tyrosine 5-phosphate acyltransferase: glucopyranose glucosamine- uridylyltransferase: acetylmuramoyl- decarboxylase acetyl-CoA formate 5-phosphate diphosphate 3-phosphate 3-oxoacyl-[ACP] protein 3' to 5' DNA complexRecA filament- serine carrying a 3'-monophosphate enolase: eno galE fumarase C: fumC lpd sucB sucA phosphate pyrophosphohydrolase: Spy lpxD hydroxymyristoyl) octulosonate protein] 1-phosphate heptose 1-phosphate galT acetyl-CoA 2-dehydro-3-deoxy-6- kinase: yeaG proofreading endoprotease: disulfide bondthiol- D-xylulose crotonyl-[acyl- 3-deoxy- L-alanine--D- glycerate 2- acyl-carrier- endolytic murein DNA-3- reductase: fabG DNA complex YgdI QmcA UDP-2,3-bis[O-(3R)- -α-D-glucosamine 8-phosphate dehydratase: acetyltransferase: adenyltransferase: formate [+ 4 isozymes] L-ribulose-5- phosphate phosphogalactonate 3-ketoacyl-CoA S-sulfo-L- pyruvate- salicin 6- nudB RNA exonuclease: degQ disulfide kinase: carrier-protein] dTDP-4- dTDP 4-keto- glutamate a reduced kinase: garK protein] transglycosylase: acyl-[acp]:1-acyl- undecaprenyl- acyl-[acp]:1-acyl- [protein-PII] 3-ketoacyl-(acyl- L-allo- serine/ stabilisation: D-manno- 3-hydroxymyristoyl]- synthase: kdsA fabZ hldE phosphate 4- aldolase: dgoA carbon- thiolase: fadA flavodoxin phosphate methyladenine nucleoside triphosphate decapping xylB UDP-3-O-(3- 2-phospho-D-glycerate dehydrorhamnose 6-deoxy- glmU ligase: murD hydrogenlyase hydrogenase 3 acetyltransferase: mltG sn-glycerol-3- pyrophosphate cysteine uridylyltransferase: threonine threonine dnaQ recO serine exchange: reductase: fabI octulosonate α α β citrate synthase: gltA fumarate epimerase: glycerate 2- phosphorous oxidoreductase: sn-glycerol-3- glucohydrolase: glycosylase: alkA carrier-protein) hydrolase: 1-deoxy-D- -D-glucosamine hydroxymyristoyl) 3-hydroxyacyl- 3,5-epimerase: rfbC D-glucose N-acetyl- -D- ADP-D-glycero- - complex: hycD eutD 2-dehydro-3-deoxy-6- phosphate 2-O- acetyl-CoA C- synthase: glnD pyrophosphohydrolase: aldolase: ltaE protein [+ 2 isozymes] recR recF endoprotease: a [protein disulfidedsbD 8-phosphate KDO-8P 2,3-bisphosphoglycerate- hydrogenase: araD kinase: glxK lyase: phnJ pyrophosphatase: ydbK phosphate 2-O- bglB reductase: nudC a stabilized xylulose 5- tyr UDP-2,3- glucosamine N- [acp] transaminase: glucosamine D-manno-heptose UDP-N- hycC hycF hycG phosphogalactonate acyltransferase: cysM mazG kinase: srkA a nucleoside 5'- degS isomerase] YobA a butanoyl-[acp] synthase: kdsA independent colanic acid building blocks biosynthesis fumarate reductase: pyruvate decarboxylation to acetyl CoA phosphate a mature peptidoglycan a nascent peptidoglycan acyltransferase: plsC lpxT acyltransferase: ECB_04076 cytidine RecA filament- 2'-deoxyadenosine phosphate diacylglucosamine acyltransferase: dTDP-4-dehydro- 1-phosphate ADP-L-glycero-D- citrate hycB hycE fdhF hycE hycB [+ 2 isozymes] a malonyl- fadI dAMP sn-glycerol monophosphate with reduced L- dehydratase: vioA acetylmuramoyl- 2-phospho-D-glycerate acetyltransferase: pta aldolase: ECB_03722 5-phospho-α- with (L-alanyl-γ-D-glutamyl- (meso-DAP containing) plsC an alkylated [DNA] a cis,cis-delta19,31- a [protein] (L-serine/L- DNA complex a polypeptide YbaL lpxD phosphoglycerate β-L-rhamnose mannoheptose 6- meso- frdA frdD frdC frdB hycG hycF D-xylulose [holo malonate β cysteine residues YajR β-ketoacyl-ACP diphosphatase: lpxH 3-deoxy- fabA β-D-glucose N-acetylglucosamine- L-alanyl-- a [pyruvate 5'-deoxyadenosine N-methylacetamide a uridylylated -D-glucose nucleobase 3-oxo-C50:2-[acp] a 5'-phospho- acetaldehyde threonine) phosphate 3-phosphate KDO-8P UDP-2,3-bis[O-(3R)- mutase: gpmM α α diaminopimelate citrate hydro- hycC hycD decarboxylase D-ribose 1,2- met meso-2,6-diaminopimeloyl- with GlcNAc terminus di-trans,octa-cis lipid A-core 1- acetate acetyl-CoA CO a reduced salicyl alcohol NMN gly synthase: fabF D-manno- 6-phosphate dTDP-4- 1-phosphate epimerase: rfaD -D-glucose UDP- -D- D-glutamate 5-phosphate acetyl phosphate D-glyceraldehyde 1-cis-vaccenoyl-2-palmitoleoyl- S-sulfo-L-cysteine 2 PII protein 6-phosphate adenosine-[RNA] lipid X a (2E)-octadec- dTDP-viosamine CO H succinate dehydrogenase pyruvate cyclic phosphate D-alanine) tetrapeptide -undecaprenyl flavodoxin 3-hydroxymyristoyl]- octulosonate dehydrorhamnose β 1-phosphate galactose lyase: acnB 2 2 acyl-carrier diphosphate acetyl-CoA (5Z)-tetradecenoyl-CoA 1,2-dimyristoyl- β-ketohexanoyl- 3-phospho-D-glycerate uridyltransferase: ADP-L-glycero- - Macromolecule Modification H E2 protein] N 6 pyruvate 3-phosphate sn-glycerol-3-phosphate CpxP α 2-enoyl-[acp] 2 phosphate 3-deoxy- -D-glucosamine 8-phosphate reductase: rfbD dTDP-viosamine glmU D-manno-heptose citrate hydro-lyase protein] sn-glycerol [acp] lipid A glucose-6- UDP-N- -lipoyl-L-lysine acetate kinase: purT superpathway of acetate D-manno- UDP-2,3- phosphatase: enoyl-[acyl- dTDP-β-L- acetyltransferase: (cis-aconitate- pyruvate:[dihydrolipoyllysine- 3-phosphate synthase: fabB disaccharide phosphoglycerate phosphate UDP-N-acetyl- acetylmuramoyl- D-alanine tRNA processing lipoate acetate kinase: ackA utilization and formation DjlA superpathway of octulosonate diacylglucosamine kdsC carrier- rhamnose vioB α forming): acnA residue acetyltransferase]- synthase: lpxB kinase: pgk α-D-glucose isomerase: -D-glucosamine L-alanyl-D- acetyltransferase YphA unsaturated fatty acids 8-phosphate diphosphatase: lpxH protein] dTDP-N- lipoyllysine 2- a 3-oxohexanoyl-[acp] lipid A pgi glutamate--2,6- 2-oxoglutarate decarboxylation to succinyl-CoA 6 an acetyl-[holo acetate a [bis(guanylyl molybdopterin) hydrogen (1S,2R)-1- (S)-3-hydroxy-(11Z) (2R,3S)-3- D-ribulose a [protein]- a trans-2- biosynthesis (E. coli) phosphatase: KDO 6-phosphate acetylviosamine glycogen biosynthesis I (from ADP-D-Glucose) D-alanine--D- cis-aconitate a polycistronic N -(dihydrolipoyl) oxidoreductase: aceE acetate acetyl-CoA [bis-MGD cofactor glutathione 2-hydroxyethyldisulfide a single stranded DNA MoO - 6-decylubiquinol an L-leucyl- L-cysteine a 9S rRNA a cis,cis-delta11,23- L-threo-3- acetaldehyde pyruvate RNA butanal YbiJ reductase: fabI 13-DPG enterobacterial common antigen biosynthesis malonate cofactor chaperone]- 2 a protein ser C-(indol-3- cys a peptide 5-phosphate enoyl-[acyl- 2'-deoxyguanosine a protein a protein a (3R)-3- disaccharide lipid X diaminopimelate tRNA precursor lysine:NAD+ GTP peroxide [tRNA Leu ] inosine desulfurase -octadecenoyl-CoA 3-hydroxyC42:2-[acp] isopropylmalate phenylserine L-histidine kdsC phosphoglucomutase: alanine synthetase S-sulfanyl-L-cysteine chaperone]-bis-MGD molybdopterin 3-hydroxyacyl-CoA 3-isopropylmalate D-ribulose 5- protein- alcohol 3-oxoacyl-[ACP] 3-deoxy-manno- β-D-glucose ligase: murE D-threo-isocitrate a [2-oxoglutarate oxidoreductase: lpd decarboxylase acetate molybdopterin yl)glycerol 3-oxoacyl-[ACP] carrier protein]enoyl-[acyl- 3'-monophosphate hydroxydecanoyl- tetraacyldisaccharide a stearoyl-[acp] glyceraldehyde- pgm F6P ligase: ddlB a [pyruvate a [pyruvate (AMP- cofactor dehydrogenase: serine reductase: fabG lipid A α hydro-lyase: acnB dehydrogenase acyl-carrier kinase: purT 3-phosphate dehydrogenase: reductase: fabG phosphate 1- histidine dehydrogenase: carrier- [acp] KDO 4'-kinase: lpxK octulosonate triose- -D-glucose 1-phosphate 6-phosphate dehydrogenase dehydrogenase 2-hydroxyethyldisulfide exodeoxyribonuclease quinol:hydrogen acetoin protease: YggE disaccharide 3-phosphate α-D-glucose UDP-N- D-alanine--D- E2 protein] N 6 ribonuclease: protein] forming): acs cysteine fadJ ribonuclease: leuB ribonuclease dehydrogenase: autokinase: adhE 3-ketoacyl-(acyl- (3R)-3- cytidylyltransferase: mannose-6- D-threo-isocitrate 2-oxoglutarate 6 6 acetate reductase: yghU peroxide leucyl- 3-ketoacyl-(acyl- synthesis: protein] phosphate dehydrogenase: alanine rne E2 protein] N E2 protein] N -S- bis-MGD cofactor VII: xseA xseB bis(molybdenum tryptophan inosine aminopeptidase: rne phenylserine PH: rph yajO btsS lon YccF carrier-protein) hydroxydecanoyl- 3-deoxy-manno- lipid IV synthase: lpxB ECB_02817 1-phosphate dTDP-glucose acetylmuramoyl- polymyxin resistance hydro-lyase -lipoyl-L-lysine decarboxylase: kinase: ackA tRNA--protein desulfurase: 3-hydroxyacyl-CoA carrier-protein) 3-isopropylmalate alcohol reductase: FimC A isomerase: gapA phosphate ligase: ddlA -dihydrolipoyl- acetyldihydrolipoyl- chaperone: fdhD 2-hydroxyethyldisulfide ssDNA-specific oxidoreductase: synthase: pepA aldolase: ltaE poxB 1-deoxy-D- reductase: octulosonate lipid A pyrophosphorylase: L-alanyl-γ-D- (cis-aconitate- sucA ribonuclease: lipoate cofactor) transferase: aat nucleosidase: iscS dehydrogenase: dehydrogenase [+ 16 isozymes] dehydrogenase: fabI [acyl-carrier 3-deoxy-manno- tpiA UTP--glucose- isomerase: dihydrolipoate a tRNA precursor polynucleotide D-gluconate L-lysine L-lysine acetyl phosphate acetyl-CoA reductase: yfcG exonuclease: recJ ECB_01628 trpB trpA reductase: xylulose 5- a [protein]- a peptide a peptide cytidylyltransferase: 3-deoxy- D-glyceraldehyde α-D-glucose glutamyl-meso-2,6- UDP-α-D-glucuronate rne acetyltransferase: synthase: mobA rihC fadB (decarboxylating) adhP an acyl-[acyl- ECB_04076 protein] disaccharide octulosonate DHAP 1-phosphate manA rfbA D-alanyl-D-alanine forming): acnA with a 5' phosporylase: cydB cydA cydX ECB_04076 phosphate N-phospho- 2'-deoxyguanosine stearate 3-phosphate 6-phosphate dehydrogenase: lpd degradation 3-oxo-(11Z)- a single- a nucleoside carrier protein] dehydratase: fabZ ECB_02817 D-manno- uridylyltransferase: α diaminopimelate aceF conversion of succinate to propionate sulfo-bis(guanylyl a [bis(guanylyl an S-sulfanyl- a 5S rRNA a cis,cis-delta11,23- : dmlA acetoin RNA L-histidine n-butanol a (3R)-3- tetraacyldisaccharide cytidylyltransferase: -D-mannose dTDP-glucose UDP-glucuronate extension and pnp D-glyceraldehyde a proteinogenic octadecenoyl-CoA stranded RNA 4-methyl-2- benzaldehyde diphosphate YggT octulosonic UDP-N-acetyl-α-D-glucosamine D-threo-isocitrate a [2-oxoglutarate a [2-oxoglutarate molybdopterin) cofactor a single-stranded bis(guanylyl L-leucyl-[protein] Leu a peptide 3-oxo-C42:2-[acp] gly hydroxyhexanoyl-[acp] 3-hydroxydecanoyl- 3-deoxy-manno- 4'-kinase: lpxK kdsB galU 6-phosphate pyrophosphorylase: phosphoglucomutase: dehydrogenase: arnA a long 3' trailer [+ 2 isozymes] D-gluconate molybdopterin) cofactor 2-mercaptoethanol GSSG a ribonucleoside a tRNA 3-phosphate trp D-ribofuranose ala [L-cysteine amino acid YdbJ acid D-alanyl- chaperone]-L-cysteine oligodeoxyribonucleotide molybdopterin) oxopentanoate YeiS octulosonate UDP-N- rffH pgm dehydrogenase dehydrogenase D-gluconate succinyl-CoA 5'-monophosphate 6-decylubiquinone H O hypoxanthine desulfurase] [acp] α β 2 (3R)-3- transferase: lipid IV CMP-KDO UDP- -D-glucose phosphomannomutase: D-alanine- UDP- -L-threo-pentapyranos-4-ulose isocitrate 6 6 a tRNA precursor methylmalonyl- L-galactonate cofactor cytidylyltransferase: A α E2 protein] N E2 protein] N -S- kinase: gntK phosphate dehydrase: fabA fructose cpsG acetylglucosamine dTDP-α-D-glucose -D-glucose dehydrogenase: icd with a 5' hydroxyhexanoyl- kdsB waaA adding UDP-4-amino-4- -dihydrolipoyl- succinyldihydrolipoyl- propionyl- CoA degradation acetyltransferase: bisphosphate di-trans,octa-cis- 2-epimerase: wecB 1-phosphate extension and a D-gluconate acetyl-CoA [acyl-carrier a (2E)-dec- α UDP- UDP-glucose 6- phosphomannomutase: enzyme: deoxy-L-arabinose L-lysine L-lysine CoA:succinate mutase: scpA aldehydo-L- eutD -Kdo-(2->6) 3-deoxy- biotin-carboxyl carrier undecaprenyl phosphate α dTDP-glucose 4,6 2-oxoglutarate kinase: idnK YgdD protein] 2-enoyl-[acp] CMP-KDO aldolase: fbaB cpsG UDP-N-acetyl- -D-glucosamine UDP-N-acetyl-α-D-mannosamine glucose-1-phosphate murF short 3' extension D-gluconate 1 YgiW -lipid IV D-manno- glucose 4- dehydrogenase: dehydratase: rfbB aminotransferase: arnB RNase BN CoA galactonate phosphate a [TusD sulfur- an N - a 2-oxo an apo-[c-type an alkylated a precursor of a double a dipeptide with a an [RNA]-3'- a [protein chain (2E,7Z)- 5-dehydro- L-glycero- A protein assembly α adenylyltransferase: L-galactonate a [TusE sulfur carrier a heme(III)-bound an [oxidized a cis,cis-delta15,27- a cis-delta17-3- NADH H O dehydratase: fabZ fructose -D-mannose 6-phosphate 2-oxoglutarate met 2 2 L-galacto- trans-2- octulosonic epimerase: ugd UDP-N-acetyl-D- dTDP-glucose 4,6- β ribonuclease: transferase: acetyltransferase: pta protein]-L-cysteine carrier protein]-S- methyladenine a CcmAB complex carboxylate cytochrome] adenine in DNA large subunit of IMP a protein stranded DNA dGTP C-terminal L-proline ribonucleoside- elongation factor hexadecenoyl-CoA 4-deoxy-D- a protein a protein YejM UDP-N-acetylglucosamine--undecaprenyl- glgC UDP-N-acetyl- UDP-4-amino-4-deoxy- -L-arabinopyranose dihydrolipoyltranssuccinylase: oxidoreductase: CcmCDE complex DsbA protein] dGMP 3-hydroxyC46:2-[acp] hydroxyC36:1-[acp] 34 3-hydroxyacyl- bisphosphate galE 1-phosphate RNase D D-malate scpC sulfanyl-L-cysteine in RNA with reduced L- hydrogenase 3 DNA 3'-phosphate P]-L-lysine enoyl-CoA glucuronate octuluronate decenoyl- acid biotin carboxyl- mannosamine dehydratase: rffG α rbn (R)-methylmalonyl- lgoD 3-oxoacyl-[ACP] 3-oxoacyl-[ACP] RNA 3'- 5-dehydro- L-glycero- aldolase: fbaA UDP-α-D- phosphate N- a (1->4)- -D-muramoyl- UDP-4-amino-4- sucB exonuclease: degradation propanoyl-CoA dGMP 5'-phosphate endonuclease: EF-P-Lys34 hydratase: [acp] ACP transferase: carrier protein mannose-1-phosphate dehydrogenase: dTDP-4-dehydro-6- ADP-α-D-glucose ribonuclease CoA D-tagaturonate cysteine residues nucleoside triphosphate reductase: fabG reductase: fabG terminal 4-deoxy-D- L-galacto- protease: UDP-α-D- glucuronate acetylglucosaminephosphotransferase: rfe α-D-glucan L-alanyl-γ-D- RNase D 3 methyl- phosphohydrolase: Xaa-Pro NADH hydrogen:oxygen hydroxylase: dehydratase: fabA isomerase: guanylyltransferase: α deoxy-L-arabinose rnd ribonuclease TusD:TusE N1- release of heme- methionine- hydrogenase ralR pyrophosphohydrolase: phosphate fadJ glucuronate octuluronate ptrA YfiR waaA biotin- wecC deoxy- -D-glucopyranose glycogen glutamyl-meso-2,6- exonuclease: P: rnpA adenine DNA aminopeptidase: 3-ketoacyl-(acyl- 3-ketoacyl-(acyl- dipeptidase: pyrophosphatase: oxidoreductase: epmC RbbA KDO galactose cpsB di-trans,octa-cis formyltransferase: arnA Degradation/ (R)-malate sulfurtransferase: methyladenine bound CcmE: oxo-acid inosinate umpG recombination- enoyl-CoA fabA UDP-N-acetyl-α-D- rnd RNase T PH: rph 3 maturation mazG carrier-protein) carrier-protein) pepQ nudC hyaC hyaB hyaA an [RNA]-3'-cyclase: rtcA a [protein chain isomerase: L-glycero-kinase: ydjH [acetyl-CoA- α lipid I dTDP-4-dehydro- synthase: diaminopimeloyl- -undecaprenyl D-malate Secondary Metabolite Degradation demethylase: glycosylase: nucleosidase: deoxyribonucleoside pepB a (2E)-hex-2-enoyl-[acp] transferase: α-Kdo-(2->6) GDP- -D- mannosaminouronate exonuclease:polynucleotide Utilization/ tusE ccmB ccmA transaminase: protease: hycI promoting reductase: reductase: ribonucleoside-2',3'- elongation factor hydratase: kduI a peptide a peptide a (3Z)-dec- carboxylase] fructose 1,6- 6-deoxy-D-glucose glgA D-alanyl-D-alanine phosphate UDP-4-deoxy-4-formamido- superpathway of glycolysis and Entner-Doudoroff dehydrogenase tag 3-deoxy-D- L-galacto- YrbG waaA -lipid IV mannose β rnt Assimilation - Other alkB ybdL ppnN 5'-monophosphate nuclease: rpnA dGMP β fadB A -L-arabinopyranose phosphorylase: ECB_04076 ECB_04076 cyclophosphate EF-P]-N-( -lysyl)-5- glycero-2,5- octuluronate hexanoyl-[acyl- 3-enoyl-[acp] ligase: birA bisphosphate transaminase: wecE a (1->4)- (decarboxylating) methylmalonyl- superpathway of hexitol degradation (bacteria) a [TusE sulfur (S)-3-hydroxy-(7Z) GDP- UDP-N-acetyl-D- pnp a tRNA precursor phosphatase: yfbR a cis,cis-delta15,27- a cis-delta17-3- 34 KDO α-D-glucan phospho-N- undecaprenyl-phosphate acetoacetate CoA anhydromuropeptides recycling fructoselysine a [TusD]-L-cysteine a C terminal a 5'-phosphooligonucleotide a proteinogenic AMP NMNH H O hydroxy-L-lysine hexodiulosonate 1-phosphate QseG carrier-protein] β-keto-cis-∆ 5 a biotinylated fructose 1,6- PRPP biosynthesis I dTDP-thomosamine β-D-glucose 6-phosphate with a short : dmlA carrier protein]-S a heme(III)-bound 2-oxo-4- an apurinic site a large subunit a proteinogenic pro 2 -hexadecenoyl-CoA transferase: mannose 4,6- mannosaminuronic 4-deoxy-4-formamido-L- degradation a CcmABCD complex a proteinogenic an apo-[c-type 3-methyladenine 32 amino- D-ribofuranose 2'-deoxyguanosine a peptide 3-oxo-C46:2-[acp] oxo-C36:1-[acp] amino acid YaaU reductase: fabI 1,4-α- acetylmuramoyl- pyruvate decarboxylase: and psicoselysine -sulfanylcysteine formaldehyde an adenine in RNA succinate CcmE protein a [reduced amino acid -dodecenoyl- waaA [BCCP monomer] bisphosphatase: dehydratase: acid transferase: rffM 3' extension D-sorbitol 6-phosphate GlcNAc-1,6-anhMurNAc- amino acid methylthiobutanoate cytochrome] with within DNA of hydrogenase 3 5-phosphate D-ribose 5- dTDP-fucosamine glucan pentapeptide- arabinose transferase: arnC a tRNA (to acetyl CoA) scpB degradation DsbA protein] acid peptide hypoxanthine [acp] α ybhA gmd precursor with L-Ala-γ-D-Glu-DAP-D-Ala a dislufide bridge a hexanoyl-[acp] α-Kdo-(2-> -Kdo-(2-> phosphate acetyltransferase: rffC branching transferase: mraY α acetoacetate synthase: α [+ 3 isozymes] 4-deoxy-4-formamido- -L-arabinopyranosyl NADP + -dependent RNase D sorbitol-6- psicoselysine YjiG α 4)- -Kdo-(2- ribose-phosphate GDP-4-dehydro- lipid II enzyme: a 5' extension CpoB fabB 4)- -Kdo-(2- dTDP-N-acetylthomosamine ditrans,octacis-undecaprenyl phosphate exonuclease: acetoacetyl-CoA phosphate 2- 1,6-anhydro-N- β >6)-lipid IV diphosphokinase: prs α-D-rhamnose undecaprenyldiphospho- glucose-6-phosphate glucose-6-phosphate ribonuclease -ketoacyl-ACP a (5Z)-3- >6)-lipid IV A F6P glgB rnd transferase: dehydrogenase: D-mannitol 1-phosphate fructoselysine 3- A a biotinylated undecaprenyl dehydrogenase: zwf isomerase: pgi PH: rph acetylmuramoyl- a [TusA sulfur- an N 1 - UDP-N-acetylmuramoyl-L- an apo-[c-type iron(III)-[N-(2,3- D-myo-inositol synthase: fabF PRPP GDP-L- N-acetylmuramoyl-L- atoA atoD an intra- 3-hydroxy-5-cis- β α a siderophore- (2E,11Z)- YhiD oxododec- lauroyl TDP-N-acetylfucosamine:lipid II α RNase T srlD epimerase: frlC a [reduced a heme(III)-bound methyl red a (3Z)-docos- 5'-deoxyadenosine a colanic acid lipid A-core a cis,cis-delta13,25- a cis-delta21-3- -aspartyl dipeptide GDP- -D-glucose glu D-alanyl-D-alanine [BCCP dimer] glucose-6- a glycogen γ phosphate- -L-ara4FN ribonuclease L-alanine a [TusD]-L-cysteine carrier protein]-S- 2-oxoglutarate methyladenine alanyl-D-γ-glutamyl-meso-2,6- cys 'activated' tRNA cytochrome]-- a malonyl-[acp] dihydroxybenzoyl) Tar (2,3,4,5) a protein β-ketooctanoyl- acyltransferase: fucose N-acetylfucosaminyltransferase: alanyl- -D-glutamyl-meso acetoacetyl-CoA protein disulfide DsbD protein] CcmE protein 3-enoyl-[acp] tetradecenoyl-CoA 3-hydroxyC44:2-[acp] hydroxyC40:1-[acp] bound Fe(III) octadecenoyl-CoA dGMP adenine 5-enoyl-[acp] palmitoleoyl phosphate deformylase: arnD P: rnpA exonuclease: keto-D-fructose mannitol-1- amidase: ampD sulfanyl-L-cysteine in DNA diaminopimeloyl-D-alanine CcmH disulfide -L-serine] complex 3-hydroxyacyl-CoA D-alanyl- enoyl-CoA tetrakisphosphate [acp] ∆ 5 lpxL lauroyl acetyl-CoA biotin synthase: wecF -2,6-diaminopimeloyl- D-fructosyl- 3-oxoacyl-[ACP] 3-oxoacyl-[ACP] 3-oxo-cis- - acyltransferase: α rnt 6-phosphate dehydrogenase: chemotaxis protein D-alanine hydratase: ZinT acyltransferase: isomerase: pgi fcl D-alanyl-D-alanine 4-amino-4-deoxy- -L-arabinopyranosyl 6-phospho D-glucono-1,5-lactone acetyl-CoA galactitol 1-phosphate phosphate 5- β L-lysine reductase: fabG reductase: fabG GDP-glucose adenine YecN synthase: fabB dodecenoyl- (KDO) -(lauroyl) lpxP carboxyltransferase: carboxylase: N-acetyl- -D- L-Ala-γ-D-Glu- FMN dependent M-antigen isoaspartyl ferric-chelate methyltransferase: dipeptidase: deoxyguanylate 2 lpxL β-D-glucose ditrans,octacis-undecaprenyl phosphate (KDO) -lipid A F6P acetyltransferase: dehydrogenase: TusA:TusD N1- L,D- 32 thiol- β-ketoacyl ferric-chelate 5'-deoxyadenosine fadJ glucosyl fadJ deaminase: [acp] -lipid IV accD accA accC β N-acetylglucosaminyl 2 glucosamine(anhydrous) tRNA cytosine 2- holocytochrome NADH- ligase: waaL 3-ketoacyl-(acyl- 3-ketoacyl-(acyl- dipeptidase: reductase: cheR A GDP- -L-fucose lipid III atoB mtlD meso-DAP-D-Ala fructoselysine sulfurtransferase: methyladenine disulfide nucleosidase: mtn 3-hydroxyacyl-CoA ddpX enoyl-CoA kinase: gmk a 3-oxooctanoyl-[acp] 6-phosphate transferase: murG 6-phosphogluconolactonase: carboxypeptidase: sulfurtransferase: [acyl-carrier reductase: carrier-protein) carrier-protein) hydrolase: gmm nfeF adeD D-myo- YhbE reductase: myristoyl-acyl a carboxylated- -N-acetylmuramate 6-kinase: frlD tusD tusC tusB exchange: c synthase: ccmF azoreductase: iadA lipid IV 4-amino-4-deoxy-L- pgl 6-phosphofructokinase: L,D- demethylase: ldcA ttcA protein] nfeF dehydrogenase: glu-Me hydratase: inositol (2,4,5) fabG KDO - biotinylated A fructose 1,6- queuosine biosynthesis acetyl-CoA glcNAc-1,6- azoR reductase: reductase: Tar D-alanine a peptide carrier protein- 2 undecaprenyldiphospho- pfkB alkB dsbD 3-oxoacyl-[ACP] (KDO) -(lauroyl) arabinosyltransferase: arnT D-tagatofuranose carboxypeptidase: fructoselysine synthase: fabB fadB ECB_04076 ECB_04076 fadB dGDP hypoxanthine trisphosphate YncE a (3R,5Z)-3- 2 (palmitoleoyl) [BCCP dimer] N-acetyl-(N- bisphosphatase: ybhA F6P anhMurNAcaminidase: E. coli M dependent D-gluconate 6-phosphate ldcA a [TusD sulfur- 5-deoxy-D-ribose 3-keto-5-cis- LPS β-D-glucose (S)-3-hydroxy-(11Z) reductase: fabG -lipid IV 6-phosphofructokinase: 6-phosphate 6-phosphate UDP-N-acetylmuramoyl- a CcmE-[c-type N-(2,3- a cis,cis-delta13,25- a cis-delta21-3- a proteinogenic GDP Fe 2+ a siderophore hydroxydodec- A -lipid IV acetylglucosaminyl) [+ 3 isozymes] nagZ a [TusA]-L-cysteine two reduced acyltransferase: A 4'-α-L-Ara4N-α-Kdo-(2->4)-α- pfkA an uncharged preQ γ carrier protein]-S- tRNA containing N,N'-dimethyl-p- Fe 2+ adenine tetradecenoyl-CoA asp -octadecenoyl-CoA YheS 3-ketoacyl-(acyl- 0 fructose 1,6- 6-phosphofructokinase: L-alanyl- -D-glutamyl- D-alanine L-alanyl-γ-D-glutamyl- an [oxidized cytochrome--CcmH dihydroxybenzoyl) 3-oxo-C44:2-[acp] oxo-C40:1-[acp] amino acid 5-enoyl-[acp] lpxM myristoyl-acyl myristoyl-acyl muramoyl-L-alanyl- α phosphogluconate 7-cyano-7- tagatose-6- 1,6-anhydro-N- sulfanyl-L-cysteine an adenine in DNA formaldehyde succinate ser cysteine residues anthranilate Kdo-(2->6)-[P4'- -L-ara4N]-lipid A tRNA meso-diaminopimelate fructoselysine meso-2,6-diaminopimelate a thionucleotide DsbD protein] disulfide] complex phenylenediamine a (5Z)-3-oxotetracos- -L-serine HflD carrier-protein) 3-hydroxy cis carrier protein- carrier protein- γ-D-glutamyl-meso- dehydratase: edd fructose phosphate bisphosphatase: pfkB acetyl-β-muramate in a protein ∆ 5 fructose 1,6-bisphosphate deazaguanine 6-phosphate 5-enoyl-[acp] reductase: -dodecenoyl- (KDO) -lipid A bisphosphate kinase: pfkB ybhA 6-phosphofructokinase: UDP-N- 2 dependent dependent 2,6-diaminopimeloyl- reductase: queF anhydro-N- HdeA superpathway of purine nucleotides de novo biosynthesis II Nucleoside and Nucleotide Biosynthesis acetylmuramate:L- deglycase: frlB ECB_04076 [acp] acyltransferase: acyltransferase: superpathway of pyrimidine adenine and adenosine salvage III salvage pathways of pyrimidine xanthine and xanthosine salvage D-alanyl-D-alanine KDGP aldolase: fbaB preQ D-tagatofuranose [+ 3 isozymes] pfkA ADP-heptose:Kdo -lipid 1 acetylmuramic dehydratase: 2 lpxM lpxM 1,6-bisphosphate fructose alanyl-γ-D- a (3R)-3- A heptosyltransferase: ribonucleotides de novo biosynthesis deoxyribonucleotides fructose Aldehyde Degradation fructose 1,6- acid kinase: anmK β-D-glucose a purine base α-Kdo-(2-> 2/3-O-Ac-α-L- a 2,3,4-saturated two reduced 4-methyl-5-(2- arbutin-6- a [protein] N- a (1->4)- a [protein] (2E,9Z)- a 3'-half-tRNA D-myo- fabZ PRPP Aromatic Compound Biosynthesis glutamyl-meso- GDP-L-fucose a reduced trimethylamine a cis,cis-delta9,21-3- a cis-delta19-3- L-alanyl-L- geranyl a [protein]-L- DinF hydroxyoctanoyl-[acp] (KDO) -lipid bisphosphate tRNA-guanine bisphosphate bisphosphate 4)-α-Kdo-(2- a phosphatidylethanolamine α 2-oxoglutarate 1-ethyladenine 1,2-diacyl-sn- cysteine residues an [oxidized phosphonooxyethyl) terminal-formyl- an adenine in DNA α glu molecule with inositol (2,4,5) waaC (KDO) -lipid A 2 2'-deoxycytidine DHAP N-acetyl-β-muramate 6-phosphate lys lesion in DNA Fuc-(1->3)- - HMP-PP phosphate N-oxide -D-glucan glutamate IMP (L-serine/L- Tsr hexadecenoyl-CoA a protein methionine 2 2-keto-3- aldolase: fbaB diaminopimelate DsbA protein] TorC protein hydroxyC40:2-[acp] hydroxyC38:1-[acp] diphosphate YjjB a (2E,5Z)-dodeca- A, cold adapted gln hydrogen adenine xanthosine aldolase: fbaA transglycosylase: tgt tagatose-1,6- >6)-lipid IV D-Glc-PP-Und glycerol 3-phosphate CTP in a protein thiazole L-methionine DNA adenine threonine) enoyl-CoA protein- a 5'-OH end trisphosphate ZraP heptosyl- a peptidoglycan superpathway of methylglyoxal degradation 6-phosphate A 3-oxoacyl-[ACP] 3-oxoacyl-[ACP] geranyl periplasmic (3R)-3- deoxycytidine 2,3-dihydroxybenzoate deoxygluconate bisphosphate DHAP ligase: mpl inosine-5'-phosphate chemotaxis protein 2'-5' RNA 3,5-dienoyl-[acp] Kdo -lipid A amidophosphoribosyltransferase: purF carbonate adenosine superpathway of guanine and guanosine salvage a 7-aminomethyl-7- fructose methyltransferase: reductase: fabG reductase: fabG phosphate diphosphate hydratase: methionine- hydroxyoctanoyl- 2 dimer (meso- 4-hydroxybenzoate UDP-N-acetylmuramoyl- DNA- 1-ethyladenine protein-serine/ serine phosphorylase: ppnP deaminase: cdd biosynthesis 6-phosphate triose-phosphate deazaguanosine 34 aldolase: bisphosphate N-acetylmuramic arbutin-6- yhdJ phosphohydrolase: methyltransferase: fadJ ligase: ∆ 5 ADP-heptose--LPS diaminopimelate γ Kdo2-lipid VI fucosyltransferase: CTP:2,3,4-saturated thiamine peptide alanylglutamate threonine phosphatase: endoprotease S-oxide [acyl-carrier cis- -dodecenoyl- biosynthesis II L-alanyl- -D-glutamyl- formamidopyrimidine A demethylase: 3-ketoacyl-(acyl- 3-ketoacyl-(acyl- yrfG cheR 5-phospho-β- adenosine aldolase: eda isomerase: tpiA in tRNA methylglyoxal L-lactaldehyde kbaY kbaZ triose-aldolase: fbaA acid 6-phosphate phosphate DNA adenine dipeptidase: pepD enoyl-CoA reductase: thpR protein] [acp]:NAD+ heptosyltransferase: carbamoyl 2'-deoxyuridine xanthosine containing) (bacteria and fungi) meso-2,6-diaminopimelate glycosylase: mutM phosphoethanolamine wcaE alkB L-phosphatidate phosphate deformylase: carrier-protein) carrier-protein) phosphatase: nudI DegP: degP D-myo- D-ribosylamine phosphorylase: deoD chorismate tRNA preQ 34 S- tagatose- etherase: murQ glucohydrolase: [+ 3 isozymes] geranyl msrA YdgI phosphate phosphorylase: guanosine 1 phosphate 7''-transferase: eptB def methyltransferase: glu-Me hydratase: a ligated tRNA inositol (2,5) dehydratase: fabZ oxidoreductase: waaF cyclopropane phospholipid biosynthesis I isochorismate lactaldehyde cytidylyltransferase: synthase: thiE ascB reductase: reductase: pphA Tsr a peptide a protein-L- Ggt PspC synthetase: adenosine deoxyuridine uracil chorismate adenosylmethionine glyoxalase bisphosphate isomerase: N-acetyl-D-glucosamine curcumin degradation dam a (1->4)- inosine monophosphate fadB fabI (heptosyl) - fatty acid (CFA) phosphoribosylamine--glycine ppnP synthase: entC D-glyceraldehyde 3-phosphate methylglyoxal dehydrogenase: α-L-Fuc-(1->4) cdsA ECB_04076 ECB_04076 [+ 2 isozymes] methionine- bisphosphate 3-hydroxyacyl- 2 chorismate ribosyltransferase- aldolase: gatY 6-phosphate a [DNA]- a modified [+ 2 isozymes] a DNA 6- maltohexaose (S)-3-hydroxy-(9Z) Kdo -lipid A biosynthesis ligase: purD carB carA kinase: tdk phosphorylase: I: gloA reductase: dkgB aldA tpiA a 5'-phospho- phosphatidylethanolamine- α GDP an intra- α-D-glucan a cis,cis-delta9,21- a cis-delta19-3- a [protein] Ser/Thr 2 nucleotide- 4-oxo-2-pentenal -2/3-O-Ac- -L- acetaldehyde succinate a [reduced an N-terminal L- glt ala S-oxide [acp] a (5Z)-dodec- DHAP deoA α-D-ribose- a peptidoglycan isochorismate lyase: ubiC glyceraldehyde- isomerase: queA glyoxalase: N-acetylglucosamine- [DNA] nucleobase a 1,2-diacyl- adenine an oxidized trimethylamine formate methylaminopurine -hexadecenoyl-CoA lipopolysaccharide a [phospholipid] guanosine [+ 4 isozymes] curcumin KDO -lipidA Fuc-(1->3)-α- protein disulfide thiamin phosphate 3-oxo-C40:2-[acp] oxo-C38:1-[acp] dehydratase: fabA 5-enoyl-[acp] adenosine deaminase: add xanthine with D,D cross- synthase: menF 3-phosphate 34 yedU 3'-phosphate sn-glycerol 2 a CDP-2,3,4-saturated- DsbA protein] TorC protein methionyl-[protein] olefinic fatty acid GAR carbamoyl- dUMP 1-phosphate 4-hydroxybenzoate an epoxyqueuosine S-lactoyl- (S)-lactate D-glyceraldehyde 6-phosphate NADPH-dependent β-D-glucose glucosyltransferase: asp α phosphorylase: links (meso- isochorismate D-Glc-PP-Und diacylglycerol benzene-1,4-diol 3-oxo-cis-∆7- cyclopropane glycerol-3-phosphate 2-deoxy- - dehydrogenase: gapA in tRNA glutathione glyoxalase 3-phosphate deacetylase: nagA sulfoglycolysis curcumin 6-phosphate YqiH a (2E)-oct-2-enoyl-[acp] waaG phosphate xanthine ppnP guanosine YtjA PqiB fatty acyl dehydrogenase: gpsA phosphoribosylglycinamide D-ribose 1- diaminopimelate III: yhbO acetol tetradecenoyl- kinase: gsk 13-DPG S-lactoylglutathione glyceraldehyde- reductase: curA glucosyl- phospholipid formyltransferase 2: purT inosine phosphate phosphoribosyltransferase: gpt guanosine containing) epoxyqueuosine D-glucosamine 6-phosphate 6-sulfo-D-quinovose octanoyl-[acyl- [acp] hydrolase: yeiG L-1,2-propanediol 3-phosphate dihydrocurcumin (heptosyl) - aspartate phosphorylase: reductase: queG 37 2503 di-trans,octa-cis an α- a 2'- a [lipoyl-carrier an apo-[c-type di-trans,octa-cis adenosine D-myo- 2 a [phospholipid]synthase: cfa sn-glycerol 3-phosphate thymidine guanine L-lactate an adenine (L-threonylcarbamoyl) adenine Nα,Nε-diacetyl-lysyl- trimethylamine a dipetide with an N- (2E,7Z)- a [protein]-L- synthase: fabB dehydrogenase: sulfoquinovose (KDO) -lipid A a reduced 6 a cis,cis-delta7,19-3- a cis-delta15-3- (2E,6E)-farnesyl carrier-protein] Kdo -lipid A carbamoyltransferase: deoD (2S,3S)-2,3- phosphoglycerate 34 [+ 2 isozymes] dehydrogenase: phosphoglucosamine 2 2-oxoglutarate 1-methyl-dAMP H O ATP 5-aminopentanoate CsgB 2 FGAR NADPH-dependent adenylate in 23S rRNA -undecaprenyl 2 a tRNA precursor deoxyadenosine deoxyribonucleoside protein]-N -[(R) cytochrome] with -undecaprenyl met a protein 2',3'-cyclic inositol (2,5) YaiW a (7Z)-3- fatty acid containing phosphorylase: XMP phosphoribosyltransferase: gpt a queuosine dehydrogenase: isomerase: yihS in tRNA D-alanyl-D-alanine TorY protein N-oxide [DNA] hydroxyC38:2-[acp] hydroxyC34:1-[acp] terminal L-aspartate diphosphate tetradecenoyl-CoA methionine OsmY reductase: fabI lipopolysaccharide pyrB pyrI inosine phosphorylase: ppnP dihydroxy-2,3- kinase: pgk gldA gapA mutase: glmM diphosphate in DNA 5'-triphosphate 5-aminovalerate -dihydrolipoyl]- a dislufide bridge diphosphate enoyl-CoA protein- monophosphate bisphosphate oxotetradec- cyclopropane deoA guanine in tRNA (R)-lactate lldD dihydrocurcumin 3-oxoacyl-[ACP] 3-oxoacyl-[ACP] undecaprenyl farnesyl 6 thiol:disulfide L-amino acid N- core heptose acyl-CoA:sn-glycerol- acyl-acp:sn-glycerol- phosphoribosylformylglycinamide inosine phosphorylase: deoD a peptidoglycan dihydrobenzoate (S)-propane- 13-DPG 6-deoxy-6- reductase: curA transaminase: L-lysine protein N - reductase: fabG reductase: fabG diphosphate hydratase: serine methionine- YgjI YbaN an octanoyl-[acp] 7-enoyl-[acp] thymidine phosphoribosyltransferase: hpt 3-phospho-D-glycerate D-glucosamine 1-phosphate N 6 -L- 23S rRNA m 2 A2503 1-methyl-dAMP RNA D-alanyl-D-alanine oxidoreductase: pyrophosphate 7 (I) kinase: waaP 3-phosphate 1-O- 3-phosphate 1-O- 2,3-dihydro-2,3- 1,2-diol dipeptidase: acyltransferase: fadB protease: clpP 3-oxo-cis-∆ - synthetase: purL N-carbamoyl- guanine GMP sulfo-D-fructose Kdo -lipid A DNA gabT (dihydrolipoyl) 3-ketoacyl-(acyl- 3-ketoacyl-(acyl- phosphatase: phosphatase: S-oxide glucosyl- phosphorylase: dihydroxybenzoate tetrahydrocurcumin threonylcarbamoyladenine methyltransferase: 2 demethylase: helicase: dbpA endoribonuclease endonuclease carboxypeptidase: ccmG mnaT [+ 2 isozymes] β acyltransferase: plsB acyltransferase: plsB L-aspartate L-lactaldehyde D-lactate phosphoglycerate 6-deoxy-6- phosphotransferase: polymerase: 5-aminovalerate lysine:NAD+ pepE bacA enoyl-CoA reductase: -ketoacyl-ACP tetradecenoyl- (heptosyl) hypoxanthine ppnP 2,3-bisphosphoglycerate- glucosamine- synthase: tsaD tsaB tsaE rlmN alkB BN: rbn IV: nfo dacD carrier-protein) carrier-protein) an apo-[c-type pgpB 2 FGAM dehydrogenase: entA degradation dehydrogenase kinase: pgk sulfofructose RNA a [lipoyl-carrieroxidoreductase: lpd N-α-acetyl- (2E,6E)-farnesyl msrB PqqL OmpA synthase: fabF [acp] independent phosphoglycerate 1-phosphate lpxT dinB aminotransferase: reductase: reductase: cytochrome] hydratase: a peptide a protein-L- 3'-AMP Ins(2)P Skp -Kdo -lipid dihydroorotase: helicase: rhlB [+ 2 isozymes] 6 di-trans,octa-cis[+ 2 isozymes] 2 thymidine 2,3- mutase: gpmA (anaerobic) (quionone): dld kinase: yihV puuE protein]-N -[(R L-methionine phosphate fadJ β reductase: fabG a 2-lysophosphatidate a 2-lysophosphatidate hypoxanthine a peptidoglycan phosphoglycerate acetyltransferase: 6 ECB_04076 ECB_04076 with reduced L- methionine- -ketodecanoyl- A-phosphate phosphoribosylformylglycinamide pyrC an N -L- 2503 -undecaprenyl a (3R,7Z)-3- dihydroxybenzoate Polyprenyl Biosynthesis 3-phospho-D-glycerate 6-deoxy-6-sulfo-D- a 2-methyladenine a 5'-α- glutarate )-lipoyl]-L-lysine a cis,cis-delta7,19- a cis-delta15-3- a proteinogenic (S)-3-hydroxy-(7Z) YiaB lipopolysaccharide core phosphoribosyltransferase: gpt mutase: gpmM L-lactaldehyde glmU 37 α-D-Kdo-(2->4)-α- succinate a single-stranded a [DNA]-3'- cysteine residues (R)-S-oxide [acp] cyclo-ligase: purM thymidine AMP threonylcarbamoyladenine 5'-deoxyadenosine met di-trans,octa-cis- formaldehyde an oxidized trimethylamine semialdehyde asp phosphate -tetradecenoyl-CoA YnjF hydroxytetradec- heptosyltransferase: L-1,2-propanediol fructose 1-phosphate in 23S rRNA dAMP mature tRNA deoxyadenosine-5- Nα,Nε-diacetyl- [DNA] 3-oxo-C38:2-[acp] oxo-C34:1-[acp] amino acid synthase: fabB (S)-dihydroorotate hypoxanthine kinase: tdk N-acetyl-α-D- in tRNA D-Kdo-(2->6)-lipid ADP H + oligoribonucleotide hydroxyl acyl-CoA:1-acyl-sn- acyl-[acp]:1-acyl-sn- 2-phospho-D-glycerate oxidoreductase: 2,3-bisphosphoglycerate- undecaprenyl phosphate phosphate phosphate-[DNA] lysyl-D-alanine D-alanine TorY protein 7-enoyl-[acp] waaQ AIR phosphoribosyltransferase: hpt superpathway of 5-aminoimidazole polyisoprenoid biosynthesis (E. coli) phosphoglycerate glucosamine 1-phosphate A 1-diphosphate YcbF 3-hydroxy cis ∆ 7 glucosyl- glycerol-3-phosphate 2- glycerol-3-phosphate 2- dTMP fucO independent a 3-oxodecanoyl-[acp] dihydroorotate ribonucleotide biosynthesis mutase: gpmA 6-deoxy-6- RcsF (heptosyl) O-acyltransferase: plsC O-acyltransferase: plsC (S)-propane- phosphoglycerate N-acetylglucosamine- FimD -tetradecenoyl- 3 5-(carboxyamino) pyruvate sulfofructose- dehydrogenase: IMP enolase: eno 1,2-diol mutase: gpmM [acp] -Kdo -lipid IPP 1-phosphate K + TrkG K + YiiR 3-oxoacyl-[ACP] 2 imidazole pyrD PRPP 1-phosphate an adenine 37 a 5'-deoxyribose- N-acetyl-muramoyl-(L- a 2'- a single- 2-dehydro-3-deoxy- cytidine a HypE hydrogenase a [protein]- (2E,9Z)- a DNA with guanosine a [protein]- dehydratase: A-phosphate uridyltransferase: 34 2-oxoglutarate 1-methyl-dATP ATP H O pimeloyl-CoA a cis,cis-delta9,27-3- a cis-delta13-3- [DNA] RNA ribonucleotide aldolase: yihT 5,10- a uridine 5-phosphate- γ 2 deoxyribonucleoside PLP D-alanine 3'-AMP maturation protein- S-hydroxy- reductase: fabG PRPP pyrimidine isopentenyl- 2-phospho-D-glycerate gly in tRNA alanyl- -D-glutamyl-L- ala [DNA] stranded RNA L-rhamnonate L-tyrosine octadecenoyl-CoA cys unresolved 2',3'-cyclic RcsF fabZ orotate amidophosphoribosyltransferase: purF phosphoenolpyruvate glmU [DNA] hydroxyC46:2-[acp] hydroxyC32:1-[acp] 3-ketoacyl-(acyl- synthase: purK ribonucleosides ∆ methylenetetrahydrofolate in tRNA lysyl-D-alanyl-D-alanine) 5'-triphosphate 3-oxoacyl-[ACP] 3-oxoacyl-[ACP] adenosine 3'- S-carboxamide[HypE]-S- RNase T phosphate enoyl-CoA recombinational monophosphate L-cysteine 5-phospho-β- diphosphate - UDP-N-acetyl- cytidine protein-tyrosine L-cysteine ∆ 3 ∆ 7 phosphate exonuclease: hydratase: or Holliday + + carrier-protein) a trans- -cis- - salvage II Metabolic Regulator isomerase: idi phosphoenolpyruvate pyruvate kinase: pykF enolase: eno α sulfolactaldehyde DHAP tRNA m 2 A37 1-methyl-dATP ATP polynucleotide 2-keto-3-deoxy- reductase: fabG reductase: fabG carboxamide phosphatase: desulfhydrase: K Kup K a phosphatidate N5-CAIR orotate D-ribosylamine -D-glucosamine nucleosidase: rihB rnt fadB GfcE reductase: tetradecenoyl-[acp] glucosyl- cytidine Biosynthesis 5-carboxymethylaminomethyluridine- DNA-5'-terminal D-alanyl-D-alanine 8-amino-7- DNA D-alanine L-rhamnonate 3-ketoacyl-(acyl- 3' -> 5' phosphohydrolase: dehydratase: pphB cysM junctions, AcrZ phosphoribosyltransferase: synthetase: ppsA pyruvate kinase: pykA methyltransferase: demethylase: pyrophosphatase: phosphorylase: [+ 2 isozymes] 3-ketoacyl-(acyl- YodB ECB_04076 (heptosyl) - N 5 -carboxyaminoimidazole cytidine phosphoribosylamine--glycine DMAPP deoxyribophosphodiesterase: carboxypeptidase: oxononanoate polymerase: transaminase: aldolase: yfaU exonuclease: xthA umpG [+ 2 isozymes] enoyl-CoA created by RecADNA cis-∆ 7 - 3 pyrE 3-sulfolactaldehyde tRNA synthase: mnmE mnmG rlmN alkB ycaO pnp carrier-protein) carrier-protein) a HypE hydrogenasehypE [+ 3 isozymes] [+ 5 isozymes] a [protein]- Kdo -lipid A- CTP:phosphatidate deaminase: ligase: purD ppGpp biosynthesis phosphoenolpyruvate glyA a nucleoside 5'- a [protein]- hydratase: helicase: MlaC 2 ribonucleotide pyruvate reductase: yihU mutM dacC synthase: bioF umuC umuD reductase: reductase: maturation 3'-GMP a (3R)-3- tetradecenoyl- cytidyltransferase: cdsA geranyl adenosine monophosphate pyruvate L-cysteine K + TrkH K + bisphosphate mutase: purE cdd [+ 5 isozymes] cytosine D-ribofuranose ECB_04076 ECB_04076 L-tyrosine fadJ recG hydroxydecanoyl-[acp] [acp]:NAD+ orotidine 5'- pyruvate 2,3-dihydroxypropane a 2- protein-S-cyanate (S)-3-hydroxy-(9Z) a DNA segment uridine GAR diphosphate + a single- a nucleoside 5'- pppGpp 34 37 4-hydroxy- a nucleoside L-lactaldehyde pyruvate a cis,cis-delta9,27- a cis-delta13-3- [DNA] oxidoreductase: a CDP-diacylglycerol 1-sulfonate a 5-carboxymethylaminomethyluridine 7,8-dihydrofolate 5'-deoxyadenosine met methyladenine a 5'-phospho- formaldehyde succinate N-acetyl-muramoyl-(L- AMP diphosphate H 8-amino-7- pyridoxamine pyruvate (3R)-3- CAIR phosphate guanosine-5'- synthase: ispA phosphoenolpyruvate kinase: pykF dATP coenzyme A diphosphate stranded RNA 3-oxo-C46:2-[acp] oxo-C32:1-[acp] monophosphate -octadecenoyl-CoA NlpI cystine YijE cystine uridine in tRNA in tRNA [DNA] 2-pentenal- alanyl-γ-D-glutamyl- D-alanine oxononanoate 5'-phosphate MipA hydroxydecanoyl- fabI phosphoribosylglycinamide phosphoribosylglycinamide guanosine 3'-diphosphate triphosphate,3'-diphosphate synthetase: ppsA pyruvate galactosyl- phosphoribosylaminoimidazole- orotidine-5'- nucleosidase: geranyl 5-phosphate L-lysyl-D-alanine) [DNA] K + Skp [acyl-carrier a (7Z)-tetradec- phosphatidylserine formyltransferase 2: purT formyltransferase 1: purN 5'-triphosphate 3'- phosphatase: gpp Inorganic Nutrient Metabolism kinase: pykA glucosyl- CDP-diacylglycerol--glycerol- succinocarboxamide phosphate rihB diphosphate K + transporting K + protein] 7-enoyl-[acp] synthase: pssA GTP diphosphatase: spoT a peptide a peptide (heptosyl) - 3-phosphate 3- decarboxylase: farnesyl P-type ATPase SbmA 3 synthase: purC [+ 2 isozymes] FGAR pyrophosphokinase: relA pyruvate antibiotic antibiotic dehydratase: fabZ ∆ phosphatidyltransferase: superpathway of sulfate assimilation and cysteine biosynthesis Aromatic Compound Degradation a nascent peptidoglycan with (L- a 6-sulfo-α- a phosphorylated 3-oxo-cis- 9- Kdo -lipid A- pyrF diphosphate an N-terminal an electron- + (2R,3S)-3- 4 DNA with G- 4-nitrophenyl 2 hydrogen sulfide thiosulfate 34 an L-phenylalanyl- + a CcmH- NADP a reduced a tripeptide a cis,cis-delta7,25-3- a cis-delta11-3- N -acetylcytidine acetyl-CoA 5-oxo-L-proline an aromatic a nucleoside 2',3'- 3-hydroxydecanoyl- pgsA SAICAR uracil a 5,10- gly a 2-thiouridine alanyl-γ-D-glutamyl-meso-2,6- NADPH H D-quinovosyl prenyl phosphate FMNH hydroxylamine isocitrate mutated tRNA HipA hexadecenoyl- bisphosphate a phosphatidylserine phosphoribosylformylglycinamide synthase: ispA arginyl-[protein] Phe transfer quinone 2 isopropylmalate A mismatch phosphate PliG UDP-D- UMP biosynthesis I disproportionation [tRNA ] CcmG disulfide flavodoxin dITP hydroxyC44:2-[acp] hydroxyC30:1-[acp] amino acid cyclic phosphate K + KefB K + YfgH YejO [acp] [acp] GTP ppGpp methylenetetrahydrofolate in tRNA diaminopimeloyl-D-alanine) tetrapeptide diacylglycerol (2S)-2- 3-oxoacyl-[ACP] 3-oxoacyl-[ACP] dehydrogenase ribosomal-protein- 5-oxoprolinase: mono-, di-, or mono-, di-, or glucose:(glucosyl) synthetase: purL (2E,6E)-farnesyl sulfate 3-phospho-D-glycerate III (rhodanese) 3-phenylpropionate and 3-(3- isocitrate adenine aromatic- serine/ dehydrase: fabA 5'-phosphoribosyl-4-(N- 4-hydroxyphenylacetate degradation cinnamate and 3-hydroxycinnamate deoxyinosine triphosphate isopropylmalate L12-serine RNase BN synthase: fabB UMP hydroxyphenyl)propionate degradation reductase: fabG reductase: fabG 4 dehydrogenase pxpA glycosylase: threonine trisaccharide OmpG trisaccharide LPS α-1,3- a phosphatidylglycerophosphate diphosphate cys NADPH tripeptide pyrophosphatase: rdgB N -acetylcytidine ribonuclease: amino-acid a (9Z)-3- succinocarboxamide) kinase: FGAM sulfate thiosulfate degradation to 2-oxopent-4-enoate phenylalanyl- thiol:disulfide flavin flavodoxin- hydroxylamine hydro-lyase (2- acetyltransferase: pxpC pxpB < 600 Da < 600 Da glucosyltransferase: D-3-phosphoglycerate 5-carboxymethylaminomethyluridine- L,D- sulfoquinovosidase: aminopeptidase: 3-ketoacyl-(acyl- 3-ketoacyl-(acyl- amidohydrolase: phosphatase: mutY transaminase: kinase: a (2E)-dec-2-enoyl-[acp] -5-aminoimidazole cysteine tRNA--protein dehydrogenase prenyltransferase: NADP + nucleoside triphosphate reductase: hcp isopropylmaleate- rimL rbn oxohexadec- pyrH GDP guanosine-3',5'- adenylyltransferase: dehydrogenase: serA 3-phenylpropanoate 4-hydroxyphenylacetate oxidoreductase carrier-protein) carrier-protein) aceK DNA with hipA + KefC K + waaO phosphatidylglycerophosphatase: yfhB all-trans- tRNA synthase: mnmE mnmG carboxypeptidase: ldtD (quinone): mdaB yihQ pepT yqfB a nucleoside 5'- tyrB phosphorylated a ribonucleoside K 9-enoyl-[acp] galactosyl- a phosphatidylethanolamine lyase: purB phosphoribosylformylglycinamide pyrophosphokinase: relA bis(diphosphate) 3'- ditrans,polycis cysD cysN transaminase: trans-cinnamate transferase: aat CcmG: ccmG ubiX reductase: pyrophosphohydrolase: forming): leuC leuD an isocitrate glt removed adenine an aromatic 4-nitrophenol a D- a D- UDP thiosulfate 4-hydroxyphenylacetate reductase: reductase: RplL serine/threonine 3'-phosphate decanoyl-[acyl- 3-oxo-cis-∆ 9 - (glucosyl) - [+ 2 isozymes] cyclo-ligase: purM diphosphatase: spoT -undecaprenyl- octaprenyl- 3-phospho-hydroxypyruvate aspC 3-phenylpropionate [+ 3 isozymes] fpr mazG (2S)-2- dehydrogenase monophosphate mismatch leaving 2-oxo-acid CsgE UidB 2 GDP diphosphokinase: spoT ECB_04076 ECB_04076 MlaA glucoronoside glucoronoside AICAR GDP kinase: ndk diphosphate 3-mercaptopyruvate sulfurtransferase: 3-monooxygenase: hpaB cinnamate isopropylmalate kinase HipA carrier-protein] hexadecenoyl- (heptosyl) - UDP diphosphate APS dioxygenase: hcaF 3-(3-hydroxyphenyl) L-phenylalanyl-L- a nascent peptidoglycan with 6-sulfo-α-D- dIMP A ammonium H O a cis,cis-delta7,25- a cis-delta11-3- cytidine an AP site 3 a 5-carboxymethylaminomethyl- a CcmG protein a CcmH protein a proteinogenic a dipeptide 2 acetate reductase: fabI a phosphatidylglycerol AIR synthase [(2E synthase: ispB sseA hcaE hcaD hcaC 3,4-dihydroxyphenylacetate dioxygenase: a 7,8-dihydrofolate a tRNA Phe a 1,2-diglyceride prenylated FMNH [acp] Kdo -lipid A- AICAR kinase: ndk 3-phosphoserine propionate 34 arginyl-[protein] (L-alanyl-γ-D-glutamyl-meso- D-alanine an electron- quinovose 2 3-oxo-C44:2-[acp] oxo-C30:1-[acp] 2 GDP 2-thiouridine in tRNA + with an internal with reduced NADPH an oxidized + amino acid gln ,6E)-farnesyl- adenylyl-sulfate aminotransferase: serC [+ 2 isozymes] hcaF hcaE NADP H YibH reductase: fabG bisphosphate transformylase: UTP 3-(5,6-dihydroxycyclohexa- 2,6-diaminopimelate) tripeptide transfer quinol disulfide bridge cysteine residues flavodoxin iron(III) a decanoyl-[acyl-carrier protein] lipopolysaccharide diphosphate all-trans- kinase: cysC 3-(3- 3,4-dihydroxyphenylacetate hcaD hcaC a ferric a ferric 3-ketoacyl- cardiolipin synthase: clsA purH 1,3-dien-1-yl)propanoate hydroxamate glucosyltransferase: specific]: uppS octaprenyl hydroxyphenyl) dioxygenase: hpaD (2E)-3-(5,6- hydroxamate hydroxamate β (acyl-carrier- CTP 3-phospho-L-serine hydrogen sulfide thiocyanate sulfite UidC ABC -ketoacyl-ACP waaJ FAICAR diphosphate PAPS propanoate dihydroxycyclohexa- NlpD complex complex synthetase: 2,3-dihydroxy-2,3- 2-hydroxy-5- core oligosaccharide- a Chi-site containing a DNA-3'- an oxidized a non-methylated N-acetyl-β- an oxidized 2-deoxy-D- transporter synthase: fabF protein) galactosyl- di-trans,octa-cis 1,3-dien-1-yl) an N-terminal an L-phenylalanyl- a 1-palmitoyl-2-acyl-sn maltopentaose a cis,cis-delta5,23-3- pyridoxine Ptd Gro dihydrophenylpropionate hydroxylase: carboxymethylmuconate semialdehyde coenzyme A an apo-[aryl- H O ATP H isethionate fumarate glu octanoate a [reduced glyoxal 2 phosphoadenosine double stranded RecA 2 deoxyribose- ferredoxin [iron- 2 asp neuraminate glucose 6- β reductase: (glucosyl) - pyrG phosphoserine prop-2-enoate EntB L-lysyl-[protein] Phe lipid A (E. coli K-12 a protein ribosomal hybrid- Tap pyruvformly-cplx GTP 5'-phosphate -ketododecanoyl- 3 -undecaprenyl dehydrogenase: hcaB mhpA carrier protein] [tRNA ] -glycerol 3-phosphate hydroxyC42:2-[acp] ITP DsbD protein] IMP adenine and phosphosulfate phosphatase: serB 2-hydroxy-5- core type) (no GlcNAc) DNA with a blunt end 5-phosphate sulfur] cluster protein L11 cluster protein phosphate glyoxalase WecH [acp] ECB_04076 (heptosyl) - diphosphate 3-hydroxy- ribosomal 3-oxoacyl-[ACP] octanoul-ACP 2-deoxyglucose- pyruvate thiol- 3 cyclohydrolase: carboxyethylmuconate inosine triphosphate NADH chemotaxis protein III: yajL fructose- a (3R,9Z)-3- Kdo -lipid A- CTP adenosine reductase: cysH cis-3-(2- trans-cinnamate maltodextrin protein L11 reductase: fabG N-acetyl-β- synthetase: formate-lyase diguanylate disulfide D-fructose synthase: fabB 2 asp taurine degradation IV isethionate pyrophosphatase: rdgB oxidoreductase: methyltransferase: 6-phosphate D-fructose specific PTS hydroxyhexadec- purH salvage V semialdehyde phenylalanyl- ATPase: L-aspartate glyoxalase bisphosphate ser 2,3-DHP carboxyethenyl) phosphopantetheinyl 3'-phosphodiesterase: hydrogenase monooxygenase: phosphorylase: methyltransferase: 3-ketoacyl-(acyl- neuraminate aas phosphatase: deactivase: cyclase: dgcM exchange: NfrA 1-phosphate sulfite cyanate degradation dehydrogenase: hpaE tRNA--protein exodeoxyribonuclease metalloaminopeptidase: ravA oxidase: nucleoside triphosphate hcr cheR YdeT enzyme II a 3-oxododecanoyl-[acp] 9-enoyl-[acp] -3,5- 3-hydroxy- transferase: entD 2 large malP prmA carrier-protein) lyase: nanA adhE [+ 8 isozymes] dsbD III: elbB ∆ 9 superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) V: recC recB recD ypdE nfo ssuD a methylated hxpB 3-hydroxy cis taurine transferase: aat nadB pyrophosphohydrolase: a reduced hybrid- glu-Me an octanoyl-[acp] 2-deoxy- an [oxidized pyridoxine adenine assimilatory serine 2,3-dihydroxyphenylpropionate 5-carboxymethyl-2-hydroxymuconate cyclohexadiene- trans- subunit: hybC ribosomal reductase: Tap PflB c-di-GMP glycolate -hexadecenoyl- α-ketoglutarate- mazG cluster protein fosmidomycin Fsr fosmidomycin 3-oxoacyl-[ACP] IMP adenosine sulfite reductase CO 1,2-dioxygenase: mhpB 1,2-diol cinnamate β D-glucose DsbD protein] ArcB CTP acetyltransferase: cysE 2 carbonic α-D-glucose protein L11 ECB_04076 N-acetyl- -D- [acp] dependent taurine + reductase: fabG lipid A-core superpathway of fatty acid biosynthesis I (E. coli) phosphorylase: (NADPH): cysJ cysI 5-carboxymethyl-2- dehydrogenase: hydroxylase: 3',5'-ADP a holo-[aryl- L-phenylalanyl- a hepta-acylated core a double stranded DNA ADP phosphate H a [DNA]-3'- 2-deoxy-D-ribose glycolaldehyde α maltotetraose a cis,cis-delta5,23- IMP pyruvate anhydrase: can (2Z,4E)-2-hydroxy-6- holo-EntB Phe a proteinogenic a reduced sulfite -iminosuccinate succinate 1-phosphate mannosamine dehydratase: dioxygenase: tauD carrier protein] L-lysyl-[protein] a tRNA a 1-lysophosphatidate oligosaccharide lipid with a RecA protein a peptide H + 3-oxo-C42:2-[acp] 3-ketoacyl-(acyl- ppnP carbonic oxonona-2,4-diene-1,9-dioate hydroxymuconate hcaB mhpA hydroxyl 5-phosphate ferredoxin [iron- fabZ hydrogen sulfide O-acetyl-L-serine aminoacetaldehyde A (E. coli K-12 type) loaded 3' overhang amino acid β-D-galactofuranoseNlpE galactofuranose β-D-galactofuranose inosine 5'- adenylosuccinate adenosine delta-isomerase: hpaF sulfur] cluster YfaZ carrier-protein) a (2E,9Z)- acetyl-CoA anhydrase: cynT 2-hydroxy-6- α-D-galactofuranose ABC transporter α-D-galactofuranose monophosphate synthetase: purA CDP phosphorylase: 2,3-dihydroxy- reductase: hexadeca-2,9- ketonona-2,4- 5-carboxy-2-oxohept-3-enedioate ECB_04076 dehydrogenase: deoD O-acetylserine trans-cinnamate dienedioate α peptidoglycan α 2498 a (1->4)- FtsN dienoyl-[acp] CDP carbamate hydrogen carbonate ferric (2,3- 2-O-( -D- 1-(6-sulfo- - a cytidine (4S)-4-hydroxy- a protein with sn-glycerol L-alanyl-D- cysteamine guaB 2'-deoxycytidine adenosine sulfhydrylase: cysK 5-carboxyemethyl-2-oxo- 2,3- an acyl-[acyl- a uridine in tRNA H O oxalate formyl-CoA maltopentaose a cis,cis-delta5,17-3- glu enterobactin DHAP a signal peptide a (3R)-3- palmitoleoyl- adenylo-succinate hydrolase: mhpC SAM H O a tRNA precursor diphosphate 2 glucopyranosyl) DAP-DAP D-quinovosyl) α-D-glucan reduced L- Trg PLP deoxycholate deoxycholate reductase: a 1-lysophosphatidylethanolamine 2 GTP ATP dihydroxybenzoylserine) in 23S rRNA 2-oxoglutarate 3-phosphate glutamate S-phosphate MdtG diphosphate:oxidized O-acetylserine hex-3-ene-1,7-dioate dihydroxycinnamate carrier protein] CTP 3 hydroxyC36:2[acp] 3-hydroxy-2,4- signal fosfomycin fosfomycin hydroxydodecanoyl-[acp] [acp]:NAD+ acetyl-CoA:ACP nrdB nrdA cyanase: cynS (2Z)-2-hydroxypenta- -D-glycerate crosslink glycerol 23S rRNA 2'-O 3-oxoacyl-[ACP] cysteine residues glycerol-3- pyridoxal L-Ala-D/ NrdH glutaredoxin-like adenosine decarboxylase: hpaG dioxygenase: mhpB protein disulfide chemotaxis protein LpoA oxidoreductase: transacylase: fabH malonyl-CoA adenylosuccinate CTP sulfhydrylase: cysM 2,4-dienoate -ribose C2498 enterochelin pentadione peptide L-Glu YdiY (3R)-3- ribonucleoside- deaminase: ferric-chelate formyl-CoA maltopentaose reductase: fabG 2-keto-4- maltodextrin phosphate phosphatase: fabI XMP lyase: purB reductase: protein oxidoreductase: (2Z,4E,7E)-2- tRNA 3-amino-3- inorganic methyltransferase: oxidoreductase: methyltransferase: esterase: fes 5-phosphate peptidase: epimerase: hydroxydodecanoyl- diphosphate 2-hydroxyhepta-2,4-dienedioate GTPase: peptidoglycan LD- transferase: 3-ketoacyl-(acyl- hydroxyglutarate glucosidase: dehydrogenase: cof [acyl-carrier-protein] S nrdD nrdE nrdF add hydroxy-6-oxonona- 2-acylglycerophosphoethanolamine carboxypropyltransferase: CCA tRNA pyrophosphatase: reductase: glucosylglycerate sulfoquinovosidase: glucosidase: malZ dnaJ cheR thiolase: lsrF rseP a drug Bcr a drug phosphinate FocA phosphinate malonyl-ACP CO endopeptidase: rlmM malZ gpsA N-(2,3- ycjG [acyl-carrier protein] reductase: 2 acyltransferase: aas yjiA nucleotidyltransferase: cca nfeF phosphorylase: ycjM yihQ frc a 2-O- carrier-protein) aldolase: eda 3-hydroxy-2,4- [+ 2 isozymes] a palmitoleoyl-[acp] -malonyltransferase: xanthosine-5'- AMP cys cyanate 2,4,7-triene-1,9-dioate tapT ppa a protein with dihydroxybenzoyl) L-alanyl-L- cysteamine decarboxylase: nrdE nrdF 2-oxo-hept-3-ene-1,7- [+ 8 isozymes] mepA methylcytidine 2498 reductase: Trg glu-Me DHAP pentadione pyridoxal a peptide dehydratase: fabZ fabD phosphate:L- UDP inosine 2-hydroxy-6- a disulfide bond glutamate an acetyl-[acp] fabB 2-oxopent-4-enoate dioate hydratase: hpaH in 23S rRNA ECB_04076 a (1->4)- -L-serine 5-phosphate 3-hydroxyacyl- glutamine adenylate oxononatrienedioate a 3-[(3S)-3-amino- α α-D-glucose maltotetraose α multidrug dCDP S-methyl-5'- a tRNA (2,3- 2+ α-D-glucose peptidoglycan peptidoglycan 6-sulfo- -D- a cis,cis-delta5,17- α -D-glucose SlyB kinase: adk 2'-deoxyuridine 5'- hydrolase: mhpC 3-carboxypropyl]- GDP + Fe glycerol formate oxalyl-CoA glyoxylate pyruvate -D-glucan Ag43 [acp] 3-oxo-cis- a malonyl-[acp] amido- UDP 2-oxopent- 2-keto-4-hydroxypimelate a phosphatidylethanolamine thioadenosine H + containing a phosphate H dihydroxybenzoylserine) D-glycerate quinovose CvpA chenodeoxycholate efflux pump chenodeoxycholate diphosphate:oxidized inosine phosphate 3 1-phosphate tetrapeptide, tripeptide, 3-oxo-C36:2-[acp] dehydratase: fabA vaccenoyl- ligase (AMP- dCDP reductase: 4-enoate (2Z)-2-hydroxypenta- uridine in tRNA AcrAB-TolC ADP NrdH glutaredoxin-like kinase: gsk 3' CCA end glycan chain 2 glycan chain 1 [acp] forming): guaA kinase: ndk nrdB nrdA hydratase: mhpD 2,4-dihydroxyhept-2-ene- 2,4-dienoate a (2E)-dodec-2-enoyl-[acp] palmitoleate acetoacetyl-[acp] protein oxidoreductase: non-specific non-specific synthase: 1,7-dioic acid aldolase: hpaI nrdE nrdF β α LamB fabF synthase: fabF β-ketoacyl-ACP IMP 4-hydroxy-2-oxopentanoate an E. coli osmoregulated an [HPr]- phosphoenol ADP-L-glycero- - -Kdo-(2-> 3-hydroxybenzoyl- a 7,8-dihydro-8- 1402 an oxidized an organic 3-hydroxy-2,4- ion/solute ion/solute GMP ATP 2'-deoxyadenosine 5'- dCTP UTP + a cytidine a UDP-sugar long chain 2+ a phosphate dodecanoyl-[acyl- a phosphatidylethanolamine α [DNA] H O ATP H O NAD(P)H H a quinone a CDP-diacylglycerol maltoheptaose maltoheptaose an isocitrate nitroaromatic pentadione a dipeptide Fe OmpW β acetoacetyl-[acp] synthase: fabH succinate semialdehyde periplasmic glucan (OPG) L-histidine pyruvate D-manno-heptose 4)- -Kdo-(2- 2 CoA 2 oxoguanine in DNA in 16S rRNA thr hydroperoxide L-homoserine Lpp carrier-protein] -ketoacyl synthase: ADP diphosphate:oxidized dUDP 4-hydroxy-2- XTP dehydrogenase polyphosphate monoester synthase: fabB salvage pathways of pyrimidine ribonucleotides >6)-lipid IV 16S rRNA 2'-O compound thiol 5-phosphate non-heme UhpC [acyl- atpC atpA reductase: NrdH glutaredoxin-like dCTP UTP oxovalerate 2-oxopent-4-enoate A threonine nonspecific non-specific non-specific reductase: fabI guanylate succinate semialdehyde -ribose C1402 xanthosine triphosphate isocitrate NAD(P)H polyphosphate peroxidase: Autoinducer- homoserine bacterial MscK carrier atpG atpD nrdB nrdA protein oxidoreductase: deaminase: dUDP reductase: aldolase: mhpE phosphoenol 3-hydroxybenzoyl- DNA- maltodextrin deaminase: ilvA dipeptidase: ion/solute ion/solute kinase: gmk cytidine dehydrogenase ADP-heptose:Kdo exodeoxyribonuclease ATPase: ychF quinone maltoheptaose pyrophosphatase: rdgB dehydrogenase nitroreductase: bcp 2 degrading racemase: atpH atpE nrdE nrdF dcd kinase: ndk nrdD phosphoethanolamine 2 CDP-diacylglycerol phosphorylase: methyltransferase: kinase: ppk pepD ferritin: a dodecanoyl-[acp] protein] (NADP + ): gabD pyruvate:protein -lipid IV - I: sbcB RadD CoA formamidopyrimidine oxidoreductase: glucosidase: malZ threonine kinase: aceK nfsB protein: lsrG ygeA transferase: opgE A diphosphatase: cdh rsmI nucleoside triphosphate [+ 2 isozymes] ftnA synthase: an acetoacetyl-[acp] atpF atpB acetaldehyde phosphotransferase: ptsI thioesterase: entH glycosylase: mutM malP a 2'-O- a phosphorylated a hydroxylamino 3,4,4-trihydroxy- a proteinogenic GDP cytidine cytidine heptosyltransferase: [+ 3 isozymes] ATPase: radD kefF pyrophosphohydrolase: dehydratase: tdcB long chain [FeO(OH) an alcohol non-specific non-specific fabB acyl-CoA hydrolysis dUTP succinate methylcytidine 1402 isocitrate group-containing an alcohol 2-pentanone amino acid D-homoserine Li + Li + YnfB MscS kinase: udk deaminase: cytosine acetaldehyde waaC [+ 2 isozymes] mazG 2-oxobutanoate an α-D-aldose UMP polyphosphate ] monomer NhaA YddB ion/solute ion/solute β-ketoacyl-ACP dADP an E. coli osmoregulated α α in 16S rRNA dehydrogenase compound 5-phosphate Na + Na + ATP dUTP cdd dehydrogenase: an [HPr protein]- a 2'- 7,8-dihydro- an apurinic site CMP -D-glucose maltohexaose -D-glucose maltohexaose 1-phosphate an (11Z)-3- GDP 2'-deoxyguanosine 5'- a 1,2-diacyl-sn-glycerol π + a phosphatidate XMP synthase: fabF a 2,3,4-saturated fatty acyl CoA adenine and adenosine salvage II pyrophosphohydrolase: CMP periplasmic glucan with N -phospho- pyruvate heptosyl- deoxyribonucleoside [DNA] ADP phosphate H 3-hydroxybenzoate 1-phosphate kinase: ndk mhpF 8-oxoguanine within DNA β-ketomeristoyl- oxooctadec- GDP diphosphate:oxidized phosphotidylethanolamine substituent ADP Kdo -lipid IV + nudI uridine L-histidine 2 A 5'-monophosphate a quinol NAD(P) non-specific non-specific laurate 11-enoyl-[acp] CMP cytosine [+ 2 isozymes] MscL [acp] a 3-oxoacyl-[acp] reductase: NrdH glutaredoxin-likeATP dADP dequalinium dequalinium ion/solute ion/solute acyl-CoA thioesterase: tesB [+ 2 isozymes] kinase: deaminase: synthase: fabB 3-oxo-cis- nrdB nrdA protein oxidoreductase:reductase: ethidium ethidium kinase: ndk adenosine acetyl-CoA MdfA BglH OmpX vaccenoyl- acyl-CoA thioesterase: yciA GTP nrdE nrdF nrdD dUMP cmk codA a drug a drug adenosine uridine a [ThiI sulfur- an aminated amino hydrogen S-methyl-5'- a guanine 966 a [protein]-L- a supercoiled a uridine 34 d-biotin d [acp] (KDO) -lipid A 2-oxobutanoate an N-terminal an L-leucyl- nitrite maltohexaose a protein with melibionate a uracil in DNA a ribonucleoside a fatty acid a phosphate + + nucleosidase: thymidylate CDP uridine 2 a phosphatidylethanolamine a uracil in tRNA carrier protein]-S- glycerophosphoserine A(H2) ser L-allo-threonine phe lys Na Na Ni(2+) ABC kinase: udk group donor arginyl-[protein] Leu peroxide thioadenosine in 16S rRNA proline (ω = 180) duplex DNA in tRNA -sulfoxide Ni 2+ Ni 2+ reductase: [tRNA ] a disulfide bond triphosphate monoester a 3-oxotetradecanoyl-[acp] 3-ketoacyl-(acyl- coenzyme A a 2,3,4-saturated fatty acid rihC synthase: thyA phosphorylase: sulfanyl-L-cysteine 2 peptidyl-prolyl DNA 3'-5' biotin transporter CDP glutaredoxin:protein 16S rRNA m G966 ribonucleoside- phenylalanine tRNA U34 acyl-ACP fabG 3-hydroxy acid L-allo-threonine lysine 2,3- + + carrier-protein) GTP dGDP adenine udp maltodextrin disulfide methyltransferase: cis-trans helicase: hydroxylase: synthetase: sulfoxide Na ChaA Na 3-oxoacyl-[ACP] dTMP kinase: ndk Nucleoside and Nucleotide Degradation Kdo2-lipid A 2-oxobutanoate nitrite reductase - α-galactosidase: uracil-DNA triphosphate dehydrogenase: dehydrogenase: transaminase: aminomutase: 3-ketoacyl- reductase: reductase: uridine tRNA uridine 4- leucyl- glycerophosphoserine hydroperoxidase: 5'-methylthioadenosine phosphorylase: reductase: grxB rsmD isomerase: tig uvrD trhO aas reductase: reductase: fabG dATP UMP phosphoethanolamine aminotransferase: NADH dependent: melA glycosylase: reductase: nrdD ilvE a polysaccharideLolB 02818 a polysaccharide (acyl-carrier- nrdD dTMP CTP tRNA--protein phosphodiesterase: ugpQ 2 ydfG ydfG a 5- epmB LpoB β-ketoacyl-ACP ECB_04076 phosphorylase: 7''-transferase: eptB sulfurtransferase: thiI katG nucleosidase: mtn malP glutaredoxin: an N - a 2'- [+ 5 isozymes] [+ 3 isozymes] bisC adenine superpathway of pyrimidine avtA nirD nirB 966 ung [+ 2 isozymes] a [protein]-L- 34 a 2,3,4-saturated 3-ketoacyl-(acyl- protein) dGDP kinase: tmk ppnP transferase: aat methylguanine deoxyribonucleoside 2-aminomalonate- 2-amino-3- 2-oxo-3- a single hydroxyuridine an alcohol synthase: fabB 3-oxoacyl-[ACP] phosphoribosyltransferase: apt uracil superpathway of purine deoxyribonucleosides degradation adenosine uracil degradation III grxC ω fatty acyl-[acp] D-β-lysine biotin Na + NhaB Na + carrier-protein) reductase: kinase: ndk deoxyribonucleosides degradation a protein with in 16S rRNA semialdehyde oxobutanoate proline ( = 0) stranded DNA in tRNA β-ketoacyl-ACP reductase: fabG dTDP phosphoribosyltransferase: upp nucleotides 7-O-[2-aminoethoxy(hydroxy) α 5'-triphosphate phenylpropanoate a polysaccharide 02815 a polysaccharide reductase: ECB_04076 a [protein] sn-glycerol S-methyl-5- -D-glucose reduced L- α-D-galactose D-gluconate uracil AMP 2'-deoxycytidine uracil α a 1,2-diacyl-sn-glycerol a [ThiI sulfur-carrier a 4-thiouracil in tRNA a deaminated A H O + maltopentaose an apyrimidinic synthase: fabF dTDP degradation II phosphoryl]- -D-Kdo-(2->4) Leu ser 2 ammonium NAD H O 1-phosphate cysteine residues ECB_04076 a (3R,11Z)-3- 2-aminobutanoate amino group donor N-terminal L- a tRNA 3-phosphate 2 adenine thio-D-ribose site in DNA a 2,3,4-saturated a (3R)-3-hydroxyacyl- 2'-deoxyguanosine -α-D-Kdo-(2->6)-lipid A protein]-L-cysteine hydroxyoctadec- dGTP kinase: ndk uracil AMP uracil leucyl-L-arginine OmpL a (3R)-3- fatty acyl-[acp] [acyl-carrier protein] deoxycytidine MliC 11-enoyl-[acp] 3-hydroxyacyl- 2'-deoxyadenosine oxygenase: YgdQ D-allose hydroxytetradecanoyl-[acp] dTTP deaminase: cdd [acp] rutA D-allose ABC D-allose 3-hydroxy cis thymidine dehydratase: fabA an (S-diacyl-sn- an (S-diacyl-sn- ferric enterobactin an [RNA]-3'- 745 32 L-glyceraldehyde type-1 transporter (3R)-3- vaccenoyl- 2'-deoxyuridine deoxyguanosine (Z)-3- O-succinyl-L- maltose a guanine + a uridine 4-hydroxy- an organic 2+ enoyl-[acyl- a phosphatidylethanolamine glyceryl)-L-cysteinyl- a phosphoglyceride glyceryl)-L-cysteinyl- 2-oxoglutarate cadaverine a 1-lysophosphatidylcholine choline Met NAD(P) FMNH his717 an alcohol Ins(1)P selenate Cu hydroxymyristoyl- (3R)-3- adenosine complex initiator tRNA met ribonucleoside- in 23S rRNA 2 in tRNA ArcB-P L-kynurenine 3-phosphate hydroperoxide transmembrane [acp] carrier-protein] thymidine deoxyadenosine phosphorylase: ureidoacrylate homoserine dAMP L-threonine [apolipoprotein] [apolipoprotein] 2',3'- 1 sugar alkyl aldehyde proteins selenate [acyl-carrier dehydratase: 2,3,4-saturated hydroxyacyl-[acyl- phosphorylase: deaminase: add deoD peracid 23S rRNA m G745 tRNA Um32 kynurenine- inositol- cupric aliphatic reductase: fabI cyclophosphate phosphatase: hydroperoxide reductase: rhomboid reductase: ethidium TehA ethidium YqhH protein] fabZ fatty acyl- carrier protein] a (3R)-3- Cofactor, Carrier, and Vitamin Biosynthesis deoA deoxyadenosine cadaverine ferric choline dAMP RNA 2',3'-cyclic methyltransferase: FMN methyltransferase: 4-hydroxythreonine phosphohistidine oxoglutarate phosphate reductase: BhsA an aliphatic sulfonate an aliphatic adenosine amylomaltase: yigL reductase: yahK protease: ynfH ynfG dehydratase: fabZ [acp]:NAD+ dehydratase:hydroxydecanoyl-[acp] fabZ phosphorylase: ureidoacrylate apolipoprotein N- apolipoprotein N- aminotransferase: enterobactin monooxygenase: phosphohydrolase: phosphodiesterase: rlmA reductase: trmJ kinase: thrB phosphatase: sixA transaminase: phosphatase: rclA sulfonate ABC sulfonate 3-hydroxyacyl- thymidine deoxyinosine deaminase: add O-succinylhomoserine methionine--tRNA malQ 1 glpG deoD an N - a 2'-O- [+ 3 isozymes] ahpF ahpC [+ 3 isozymes] ynfF ynfE 3-hydroxyacyl- oxidoreductase: uracil amidohydrolase: acyltransferase: lnt acyltransferase: lnt patA esterase: fes yeaW yeaX yfbR thpR fre 4-phospho- aspC suhB cleaved type-1 + transporter [acp] (3R)-3- biotin biosynthesis I phosphorylase: 2'-deoxyinosine phosphorylase: lyase: metB ligase: metG an [RNA]-3'- 745 32 Cu tetrahydromonapterin lipoate lipoate salvage I aminopropanol thioredoxin demethylmenaquinol- adenosylcobalamin methylguanine methyluridine 4-(2-aminophenyl)- L-glyceraldehyde an alcohol an aldehyde myo-inositol selenite [acp] fabI superpathway of menaquinol-8 biosynthesis I superpathway of ubiquinol- citrate lyase activation flavin biosynthesis I (bacteria and plants) 1,4-dihydroxy-2- phosphorylase: ppnP deoD rutB hydroxy-L- ArcB transmembrane ferric dehydratase: hydroxydecanoyl- biosynthesis biosynthesis and phosphate pathway 8 biosynthesis I salvage from cobalamin 2'-deoxyadenosine ribunucleoside- in 23S rRNA in tRNA 2,4-dioxobutanoate an (aminoalkyl)phosphonate an (aminoalkyl)phosphonate dehydratase: fabA 8 biosynthesis (prokaryotic) naphthoate biosynthesis I deoA inosine an N-acyl-(S-diacyl- an N-acyl-(S-diacyl- iron(III)-[N-(2,3- N-(2,3- L-1-glycero-3- D-glucopyranose maltotriose threonine proteins citrate outer PhnCDE fabA [acyl-carrier incorporation II biosynthesis I 2'-phosphate an alkylphosphonate an alkylphosphonate a malonyl-[acp] 3'-dephospho- (R)-lipoate all-trans- thymine (Z)-3- a 1-lysophosphatidylethanolamine sn-glyceryl)-L- a 1-lysophospholipid sn-glyceryl)-L- 5-aminopentanal a carboxylate glycolaldehyde trimethylamine FMN NAD(P)H H + ferric ferric EcnA a (2E,11Z)- a trans-2-enoyl- protein] chorismate 7,8-dihydroneopterin an oxidized 2-deoxy-α-D- carbamate glutamate dihydroxybenzoyl) dihydroxybenzoyl) 2-oxobutanoate succinate phosphocholine an L-methionyl- membrane QseG malonyl-CoA (2E,6E)-farnesyl 1,4-dihydroxy- cob(I)alamin Met dicitrate dicitrate a (2E)-tetradec-2-enoyl-[acp] octadeca-2,11- CoA octanoate lipoate-ATP GTP octaprenyl chorismate inosine peroxyaminoacrylate cysteinyl-[lipoprotein] cysteinyl-[lipoprotein] -L-serine] complex -L-serine [initiator tRNA ] transport [acyl-carrier protein] dehydratase: fabZ triphosphatedihydroneopterin thr thioredoxin cobalamin ribose 1-phosphate methyltransferase: isochorismate diphosphate triphosphoribosyl- octanoate- adenylate 2-naphthoate diphosphate isochorismate phosphorylase: aminoacrylate dienoyl-[acp] 3-hydroxydecanoyl- adenosyltransferase: deoxyribose 1,5- complex chloramphenicol MdtL chloramphenicol myristoyl-[acyl- bioC triphosphate 2'- synthase: entC ppnP cis-vaccen- synthase: entC all-trans- chorismate dephospho-CoA non- transferase: phosphomutase: peracid carrier-protein] [acp] a malonyl-[acp] methyl ester epimerase: folX GTP cyclohydrolase 1,4-dihydroxy- btuR α 2-enoyl- isochorismate octaprenyl- synthase: citG 7,8-dihydromonapterin lipoylated lplA isochorismate uracil 2-deoxy- - inosine reductase: rutC an osmoregulated a [TusE sulfur a ring-opened 7- RNase R degradation a [DNA]-nucleotide-3'- an N-acetyl-β- RNase III mRNA an N-terminal L- 4-phospho- a uracil 1498 a debranched a [protein]-α- a 1,2-diacyl- D-glucopyranose a pyrimidine base dehydrase: fabA II: ribA thioredoxin coenzyme B deoB 34 a nucleoside 2+ 6+ ferric L-threonine 3- 2-naphthoate 12 a phosphatidylglycerol a phosphatidylglycerol a uridine in tRNA maltohexaose an acyl-[acyl- oxaloacetate syringaldazine Cu Cr ferric ferric reductase: fabI [acp] synthase: menF diphosphate 2'-(5''-triphospho- triphosphate apo domain lipoyl-adenylate synthase: menF D-ribose 1- phosphorylase: CO a prolipoprotein periplasmic glucan carrier protein]-S methylguanine in DNA substrate RNA phosphoglycolaldehyde D-hexosaminide processing alanyl-[S5 protein hydroxy-L- in 16S rRNA α-limit dextrin L-glutamate sn-glycerol 3- 6-phosphate lesion in DNA CheY-ac β-ketoacyl [acyl- chorismate α reductase: 2-deoxy-D-ribose 2 aminoacrylate carrier protein] diphosphate citrate ABC YceK -D-ribosyl)-3'- 2,5-diamino-6-(5-phospho-D- O-phosphate octaprenyltransferase: isochorismate of 30S ribosome] 3 dicitrate dicitrate YbhC putative reductase: synthase: ispB a [lipoyl-carrierligase: lplA phosphate deoD -sulfanylcysteine substrate ribosomal-protein- threonine 4-hydroxythreonine- 16S rRNA m U1498 chemotaxis protein putative diphosphate sugar oxaloacetate bifunctional polyphenol NADH chromate transporter a myristoyl-[acp] a (2E)-dec-2-enoyl-[acp] carrier protein] lyase: ubiC lipoyl- trxB menA 5-phosphate phosphate diacylglycerol CheY isochorismate all-trans- dephospho-CoA 6 ribosylamino)pyrimidin-4(3H)-one deoxyribose 1,5- phosphatase: keto-enol- cupric ABC fabI protein] N - β-N- S5-alanine N- 4-phosphate methyltransferase: maltodextrin methyltransferase: nucleoside (IDP) pyrophosphate DNA oxidase: reductase: cefoperazone cefoperazone synthase: fabB octaprenyl adenylate- 2-succinyl-5- aminoacrylate DNA- maltohexaose acyltransferase: deacetylase: exporter trans-2- 4-hydroxybenzoate apo-citrate lyase phosphomutase: hypoxanthine phosphatidylglycerol--prolipoprotein phosphoglycerol tRNA-specific 3'-phosphodiesterase: acetylglucosaminidase: acetyltransferase: dehydrogenase: rsmE phosphorylase: cheR diphosphatase: yigL isomerase: glycosylase: pgeF reductase: yieF β-ketoacyl-ACP a cis- 2-succinyl-5- octanoyl-L-lysine -protein diaminohydroxyphosphoribosylaminopyrimidine enolpyruvyl- deoxyribose- hydrolase: rutD formamidopyrimidine RNase R: rnr ribonuclease glucosidase: malZ phosphatase: a 3-oxoglutaryl- diphosphate phosphoribosyl- deoB nfo an N 3 - a [protein]-L- plsX fumA nth tetramethoxy cobB ndh YbhFSR decenoyl-ACP lipoyl deaminase: ribD demethylmenaquinol-8 diacylglyceryl transferase: lgt transferase: opgB 2-thiouridylase: nagZ an N-terminal N-acetyl-rimJ 3-amino-1-pdxA malP yibQ pgpB [+ 3 isozymes] Cd 2+ ZupT Cd 2+ synthase: fabF vaccenoyl-[acp] enolpyruvyl- 7,8-dihydromonapterin ligase: lplA (R)-1-amino- a reduced 6-hydroxy-3- phosphate glycosylase: mutM III: rnc 1498 5 an apyrimidinic 3+ [acp] methyl ester dephospho-CoA 2-deoxy-D-ribose malonate methyluracil glutamate-O a nucleoside 5'- azobismethylene + Cr β isomerase: fabA synthase: a [lipoyl-carrier hypoxanthine mnmA L-alanyl-[S5 protein hydroxyacetone an acyl phosphate a phosphatidate D-glucopyranose enol-oxaloacetate CheY Cu N-acetyl- -ketopalmityl- 6-hydroxy-3- 4-hydroxybenzoate transferase: citX 5-amino-6-(5-phospho- 2-propanol O thioredoxin NAD salvage pathway III cyclohexene- aldolase: deoC semialdehyde monophosphate site in DNA lipA 6 5-phosphate in 16S rRNA -methyl-ester quinine HslJ EcnB N-acetyl-α-D- 3-oxo-glutaryl- dihydromonapterin protein]-N -[(R -2-phosphate 1-carboxylate hydroxylase: an (S-diacyl-sn- an OPG-6- 2,6-diamino-4- glycolaldehyde an N-acetyl-β- of 30S ribosome] α 1-phosphate α-D-glucose N-acetyl-α-D- galactosamine [acp] a (3Z)-dec-3-enoyl-[acp] cyclohexene- octaprenyltransferase: a holo [citrate a [lipoyl-carrier D-ribosylamino)uracil malonic a 1,2-diacyl- an apurinic site a nucleoside 5'- a [DNA]-3'- RNase III -D-glucose maltopentaose maltotriose [acp] methyl ester 34 a diribonucleotide an alcohol galactosamine reductase: folM 6 )-lipoyl]-L-lysine 1-(β-D xdhC xdhB xdhA glyceryl)-L-cysteinyl- sn-glycerol 1-phosphate (glycerophospho) a 2-thiouridine a [TusE sulfur carrier hydroxy-5-(N-methyl) phosphate D-hexosamine a single- 1-phosphate galactosamine transporter synthase: fabB 1-carboxylate ubiA lyase acyl- protein]-N -[(R 5-amino-6-(5- synthase: menD D-glyceraldehyde 3-phosphate semialdehyde sn-glycerol within DNA monophosphate hydroxyl processing chloride ClcB chloride 1-phosphate reductase: fabG deoxyribose- acetaldehyde [apolipoprotein] -D-glucose stranded RNA β-keto-cis-∆ 5 - synthase: carrier protein] )-lipoyl]-L-lysine phosphoribosylamino) glutathione ribofuranosyl) 2-succinyl-5-enolpyruvyl- in tRNA protein]-L-cysteine formamidopyrimidine complex cis-vaccenate tetrahydromonapterin phosphate guanosine xanthine reductase: rutE product mRNA a 3-oxohexadecanoyl-[acp] 3-ketoacyl-(acyl- menD 3-octaprenyl-4- citrate lyase uracil reductase: ribD redox nicotinamide 6-hydroxy-3-cyclohexene- acetaldehyde dodecenoyl-[acp] ribosylnicotinamide aldolase: nucleotides malonic cetylpyridinium cetylpyridinium carrier-protein) 2-succinyl-5- hydroxybenzoate synthetase: reactions II 1-carboxylate dehydrogenase: Gdx synthase: fabB 5-amino-6-(5-phospho- kinase: nadR deoC degradation III xanthine:NAD+ semialdehyde 3-oxoacyl-[ACP] (1R,6R)-2- a [DNA]-nucleotide- RNase E mRNA 5-phospho-α- guanosine 2251 (5Z)- D-glucose 1- ethyl-(2R)- trans-∆ 2 - D-myo-inositol phosphoryl- chloride ClcA chloride YddL YaiO guanidinium guanidinium reductase: enolpyruvyl-6-hydroxy- 3-octaprenyl-4- citC D-ribitylamino)uracil NMN mhpF oxidoreductase: a [TusA]-L-cysteine an [L-cysteine desulfurase]- a DNA containing an glutathione dCTP a [protein]-L-lysine 2-C-methyl-D-erythritol- a uridine in tRNA a nucleoside 3',5'- histidinol a nucleoside a nucleoside 5'- a (5Z)-3-oxododec- glutathione reductase: ydfG L-1-glycerophosphorylethanolamine palmitate bromoacetate glutathionylspermidine processing D-ribose 1,2- methyl-(3S)- (1,2,3,4,5)- reductase: fabG ECB_04076 3-cyclohexene- hydroxybenzoate an acetyl-holo succinyl-6- xdhC xdhB xdhA S-sulfanyl-L-cysteine apurinic/apyrimidinic site 3'-phosphoglycolate dCTP in 23S rRNA 2,4-cyclodiphosphate tetradecenoyl-CoA bisphosphate phosphate decenoyl-CoA diphosphate monophosphate ethanolamine 5-enoyl-[acp] 5-amino-6-(5- D-glyceraldehyde GMP [+ 2 isozymes] peptidyl-lysine N- tRNA- hydroxybutanoate pentakisphosphate 3-ketoacyl-(acyl- 1-carboxylate [citrate lyase acyl- NMN hydroxy-2,4- acetaldehyde substrate cyclic phosphate α 23S rRNA 2'-O 1-hydroxy-2- acyl-CoA 3',5'-nucleoside histidinal/histidinol sugar 2,4-dienoyl- decarboxylase: ubiD 5-phospho- -D-ribosyl pyrophosphohydrolase: 16 β nucleoside 5 a (3R)-3-hydroxyglutaryl- phospho-D- 3-phosphate guanosine-5'- 3-hydroxypropanoate -keto ester M-antigen M-antigen 3-oxo-cis-∆ - adenylyltransferase: cyclohexadiene- acetyl-CoA urate -ribose G2251 acetyltransferase: methyl-2-(E dihydrouridine dehydrogenase: bisphosphate dehydrogenase: phosphatase: CoA carrier-protein) [acp] methyl ester (1R,6R)-2- carrier protein] ribitylamino)uracil glutathione IscS:TusA apurinic/apyrimidinic fatty acyl-CoA bromoacetate 1,2-cyclic phosphate nudI reductase: diphosphate Mn 2+ MntP Mn 2+ monomer monomer dodecenoyl-[acp] 2-octaprenylphenol D-ribulose 5-phosphate nadR 1-carboxylate acetaldehyde phosphate L-1-glycerophophorylethanolamine glutathionylspermidine 3'-phosphodiesterase: methyltransferase: phnO )-butenyl 4- synthase: dusC fadE phosphatase: hisD yigL reductase: WzxC reductase: succinyl-6- phosphatase: yigB reductase: sulfurtransferase: endonuclease: xthA synthetase: fadD dehalogenase: ribonuclease: phosphodiesterase: nucleoside triphosphate dkgA kinase: ndk undecaprenyl undecaprenyl reductase: fabG 3-hydroxyglutaryl- synthase: menH dehydrogenase: phosphohydrolase: phosphodiesterase: ugpQ amidase: gss xthA rlmB [+ 4 isozymes] diphosphate [+ 2 isozymes] 2-trans,5-cis- yciV [+ 3 isozymes] fadH D-myo-inositol ECB_04076 hydroxy-2,4- 3,4-dihydroxy- gor + purine ribonucleosides degradation tusA gstB rne phnP 2-O- 6 ethyl-2- ∆ 2 ∆ 4 a nucleoside YgiB diphosphate diphosphate [acp] methyl ester 2-octaprenylphenol 5-amino-6-(5- NAD (1R,6R)-6-hydroxy-2- mhpF yrfG endonuclease IV: nfo [+ 2 isozymes] α-D-ribose 1,5- pyrophosphohydrolase: a [protein]-N - a 5,6-dihydrouridine tetradecadienoyl- a nucleoside 5'- his trans- , cis- - a nucleoside ethanolamine a (3R,5Z)-3-hydroxydodec- cyclohexadiene- methylguanosine 2251 synthase: ispG D-glucopyranose methylacetoacetate triphosphate (2,3,4,5) a (3R)-3- dehydratase: fabZ 2-butanone- succinylcyclohexa-2,4- [+ 3 isozymes] bisphosphate mazG acetyl-L-lysine 1-hydroxy-2-methyl-2-(E) in tRNA CoA monophosphate decadienoyl-CoA 5-enoyl-[acp] 1-carboxylate 6-hydroxylase: ubiI phospho-D- [+ 2 isozymes] pseudouridine in 23S rRNA tetrakisphosphate fluoride CrcB fluoride D-xylose XylE D-xylose hydroxyhexadecanoyl-[acp] 4-phosphate diene-1-carboxylate guanosine adenosine a [TusA sulfur-carrier protein]- sn-glycerol glutathione- a [DNA]-3'- RNase E dCMP -butenyl 4-diphosphate a (2E)-enoylglutaryl- synthase: menH 3-(all-trans ribitylamino)uracil adenosine degradation an [L-cysteine ethanolamine a 5'-deoxyribose- bromide glutathione spermidine 2-phosphoglycolate a single- 3-hydroxy cis ∆ 5 - synthase: ribB GSSG acetyl-CoA nucleotides 3-phosphate a [DNA]-3'-hydroxyl AMP palmitoyl-CoA diphosphate hydroxyl (3R)-3- [acp] methyl ester (1R,6R)-6-hydroxy-2- -octaprenyl) phosphatase: ybjI o-succinylbenzoate desulfurase]-L-cysteine S-sulfanyl-L-cysteine 5-phosphate-[DNA] S-acetate processing stranded RNA guanosine degradation III hydroxypalmitoyl- dodecenoyl-[acp] succinylcyclohexa-2,4- benzene-1,2-diol 1-deoxy-L-glycero- synthase: menC pseudouridine product mRNA dehydratase: fabZ enoylglutaryl- ARP phosphorylase: adenosine curli [acyl-carrier diene-1-carboxylate 2-octaprenyl-6- tetrulose 4-phosphate pyrimidine pseudouridine AMP YqjA [acp] methyl ester ppnP deaminase: secretion protein] a (2E,5Z)-dodeca- hydroxyphenol 2-succinylbenzoate AMP 3 o-succinylbenzoate ribonucleosides add kinase: psuK 6 an N - DNA combined with RNase II RNase G reductase: fabI + a [protein]-N - + a deoxyinosine N-acetyl-9-O- an L-methionyl- (2-aminoethyl) a 5,6,7,8- thiamin 2-phospho- CsgA and CsgA dehydratase: fabZ 3,5-dienoyl-[acp] methylase: ubiG 6,7-dimethyl-8- degradation guanosine pseudouridine nucleosidase: NAD 2-oxoglutarate coenzyme A [EntF L-seryl- octanoate NADPH NAD a polypeptide exogenous DNA to form an [oxidized a ribosomal an oligopeptide ppGpp degradation prenol tellurite ethylphosphate synthase: menC acetyl-L-lysine methylcytosine in DNA acetylneuraminate Met phosphonate tetrahydropteridine degradation ser D-glycerate assembly 2-methoxy- o-succinylbenzoate--CoA phosphorylase: carrier protein] [initiator tRNA ] DsbD protein] protein-L-alanine diphosphate 3-hydroxyacyl- ∆ 5 a glutaryl-[acp] methyl ester ribityllumazine cytidine 5'-phosphate amn in DNA a recombinational junction (2-aminoethyl) dihydropteridine substrate mRNA substrate mRNA tellurite cis- -dodecenoyl- 6-(all-trans- adenosine inosine guanosine ribosomal-protein- ppGpp L-serine complex 2-succinylbenzoate synthase: ribE ligase: menE cytidine deoD thiamin oligopeptidase: isopentenol reductase: [acp] [acp]:NAD+ thymine AMP methionyl-tRNA resolvasome: thioredoxin:disulfide phosphonate N- S18-alanine N- reductase: hmp exoribonuclease phosphohydrolase: ribonuclease: D-galacturonate D-galacturonate octaprenyl)phenol pseudouridine- protein-lysine fatty acyl-CoA pyridine nucleotide alanyl pyrophosphate ptrB kinase: thiM deaminase: ExuT dehydratase: fabA oxidoreductase: 3-oxopimeloyl- 4-(2'-carboxyphenyl) deaminase: cdd nucleosidase: N3- deoxyribonuclease ruvC ruvA ruvB acetyltransferase: dihydropteridine narI narG narH D-glucuronate D-glucuronate 2-octaprenyl-6- degradation 5'-phosphate deacetylase: phosphopantetheinyl synthetase: fadD transhydrogenase: aminopeptidase: formyltransferase: fmt oxidoreductase: trxA acetyltransferase: hydrolase: nudJ II: rnb nudG rng sdaB YkgH [acp] methyl ester o-succinylbenzoate--CoA superpathway of thiamin diphosphate biosynthesis I -4-oxobutyryl-CoA uridine guanine ppnN methylcytosine V: nfi phnO reductase: nfsB [+ 3 isozymes] fabI methoxyphenol 4- 6,7-dimethyl-8-(1-D-ribityl)lumazine xanthosine adenosine inosine guanosine glycosidase: transferase: entD an N-formyl- resolution of recombinational rimI synthase: fabF ligase: menE thymine cobB [+ 2 isozymes] sthA pepN (2-acetamidoethyl) a ribosomal a 6,7- a nucleoside 5'- pGp a single- prenyl phosphate [+ 3 isozymes] D-glycerate a (2E)-hexadec-2-enoyl-[acp] 1,4-dihydroxy-2- uridine demethylase: alkB junction formation a [reduced thiamin phosphate a peptide Te 0 ethanol hydroxylase: ubiH phosphorylase: phosphorylase: phosphorylase: psuG adenine L-methionyl- phosphonate protein-N- dihydropteridine stranded RNA pyruvate a (5Z)-dodec-5-enoyl-[acp] 3-oxo-pimeloyl- naphthoyl-CoA phosphorylase: met DsbD protein] monophosphate ABC-type 4-(2'-carboxyphenyl) 2-methoxy-6-all cys riboflavin pantothenate and coenzyme A biosynthesis I guanine ppnP ppnP ppnP a holo-[EntF [initiator tRNA ] of two intact strands acetyl-L-alanine a macrolide a macrolide palmitoyl-[acyl- [acp] methyl ester synthase: menB udp uracil 3''-O-acetyl- a 5'-phospho- a deoxyinosine- N-acetylneuraminate tripartite -4-oxobutyryl-CoA trans-octaprenyl- synthase: ribC superpathway of tetrahydrofolate biosynthesis 5,6- deaminase: guaD nicotinamide a [protein]-L-lysine 3',5'-ADP NADH NADP + acetate a polypeptide xanthosine adenosine inosine guanosine ADP-ribose a cytosine in DNA formaldehyde succinate L-seryl-carrier AMP octanoyl-CoA diphosphate [DNA] [DNA]-3'-hydroxyl an L-amino acid Mn 2+ Mn 2+ antibiotic antibiotic carrier-protein] synthase: fabB 2-methoxy-1,4- L-cysteine:[protein 1,4-dihydroxy-2- dihydrothymine uridine efflux pump 1,4-dihydroxy- protein] 2+ MntH 2+ reductase: fabI riboflavin 3-methyl-2-oxobutanoate phosphorylase: phosphorylase: phosphorylase: phosphorylase: Alcohol Degradation Fe Fe a 3-oxopimeloyl- 2-naphthoyl- benzoquinol cysteine] superpathway of pyridoxal 5'-phosphate biosynthesis and salvage naphthoyl-CoA phosphorylase: xanthine 2-octaprenyl- ppnP deoD deoD deoD CoA sulfurtransferase: 1,4-dihydroxy-2- ppnP a palmitoyl-[acp] [acp] methyl ester GTP 3-methyl-2-oxobutanoate xanthine:NAD+ phosphonate PhnCDE phosphonate 6-methoxy-1,4- superpathway of glycol 3 synthase: iscS riboflavin kinase: ribF D-erythrose naphthoyl-CoA hydroxymethyltransferase: core oligosaccharide-lipid A (E. an N - an intrastrand non- a long-chain a pyrimidine (8S)-3',8-cyclo-7,8- a double-stranded 2-dehydro-3- RNase E (2E)-2- an adenosine 34 3-phospho- 3-oxo-pimeloyl- benzoquinol 3-ureido- uracil oxidoreductase: α-D-ribose- ethanol glycerol degradation V a 1-palmitoyl-2-acyl- cellulose UDP-α-D-glucose kojibiose phenylhydantoin an mRNA riboflavin an oligopeptide Cd 2+ Cd 2+ metabolism and degradation 2-oxoglutarate adjacent cyclobutane ribonucleotide [DNA] L-tartrate degradation hydroxypenta- Arg2 Ins(1,2,3,4,5,6)P L-idarate menB L-cysteine 4-phosphate hydrolase: menI panB coli K-12 core type) (no GlcNAc) methylcytosine hν fatty acid a (3R)-3-hydroxydecanoyl-[acp] dihydroguanosine oligonucleotide a protein deoxy-D-gluconate in [tRNA ] 6 D-glycerate [acp] methyl ester methylase: GTP isobutyrate xdhC xdhB xdhA 1-phosphate degradation I phosphatidylethanolamine Zn 2+ FieF Zn 2+ desulfurase: D-erythrose- in RNA thymidine dimer in DNA (3R)-3-hydroxyacyl- type I site-specific 5'-triphosphate 2-keto-3-deoxy- sequence-specific flavin L-tartrate substrate mRNA 2,4-dienoate tRNA L-idarate reductase: fabG 1,4-dihydroxy-2- ubiE FMN cyclohydrolase α-D-ribose 1,5- ethylene glycol Fe 2+ Fe 2+ 1,4-dihydroxy-2-naphthoate 2-dehydropantoate glycerol phenylhydantoinase: cyclic pyranopterin oligoribonuclease: ATP-dependent zinc D-gluconate endoribonuclease reductase: cysJ oligopeptidase: adenosine 34 D-ribose 02651 D-ribose naphthoyl-CoA (2E,6E)-farnesyl 6-methoxy-3- sufS 4-phosphate urate ethanol [acyl-carrier protein] cellulose kojibiose pyrimidine- deoxyribonuclease: dehydrogenase: ribonuclease: tautomerase: epimerase: 3-ketoacyl-(acyl- I: folE asp phosphomutase: glycerol N3- acyl-CoA hyuA monophosphate orn metalloendoprotease: prlC diphosphate methyl-2-all- FMN dehydrogenase: ethanol dehydratase: fabZ synthase: phosphorylase: 5'-nucleotide hsdR hsdS hsdM dehydrogenase: GhoS: ghoS riboflavin dmlA rne pptA deaminase: gudD palmitate carrier-protein) 1,4-dihydroxy- an S-sulfanyl-[L- 2-dehydropantoate deoB glycolaldehyde dehydrogenase: methylcytosine deoxyribodipyrimidine synthetase: synthase: moaC hflK hflC ftsH trans-octaprenyl- adenylyltransferase: 7,8-dihydroneopterin epd bcsB bcsA ycjT nucleosidase: a double stranded kduD [+ 4 isozymes] reductase: fre tadA D-myo-inositol 2+ 2+ all-trans- (R)-3-amino-2- dehydrogenase: 3-hydroxyacyl-[acp] phenylureidoacetic a nucleoside 5'- 2-hydroxy-3- 34 Fe FeoB Fe reductase: 2-naphthoyl- cysteine desulfurase] a [ThiS sulfur- 2-reductase: ilvC D-ribose 5- reductase: fucO gldA demethylase: alkB photolyase: phr ECB_02851 cyclic pyranopterin 3-deoxy-D-glycero- a single- a single- 2-oxopent- an inosine D-glucarate D-glycerate octaprenyl- 1,4-benzoquinol ribF triphosphate adhE ppnN DNA with 5'- reduced riboflavin a peptide oxosuccinate (1,2,4,5,6)- CoA erythronate- 2-dehydropantoate methylpropanoate phosphate dihydroxyacetone dehydratase: fabA acid monophosphate a peptide 2,5-hexodiulosonate stranded RNA stranded RNA 4-enoate in [tRNA Arg2 ] YdgA Amine and Polyamine Biosynthesis ECB_04076 cysteine :[Thil sulfur- carrier protein] terminal phosphate phosphate pentakisphosphate diphosphate 2-octaprenyl- dihydroneopterin 4-phosphate 2-reductase: panE glycolaldehyde ethanol a hepta-acylated core a (2E)-dec-2-enoyl-[acp] UDP β-D-glucose hydrolase: FAD a 1-lysophosphatidylethanolamine a long-chain cellulose D-glucopyranose a (3R)-3-hydroxypimeloyl- synthase: ispB 3-methyl-6- protein cysteine] ThiS triphosphate dehydrogenase: dihydroxyacetone oligosaccharide lipid a DNA with AMP D-ribose 5- nitrite nitrite menI erythronate- β glycolaldehyde formaldehyde a cytosine in RNA succinate fatty acyl-CoA diphosphate 1-phosphate a pyrimidine base superpathway of arginine and polyamine biosynthesis [acp] methyl ester methoxy-1,4- sulfurtransferase: adenylyltransferase: diphosphatase: (R)-pantoate -alanine kinase: dhaK A (E. coli K-12 type) nonadjacent thymidines glycine betaine 1,4-dihydroxy- all-trans-octaprenyl 4-phosphate dehydrogenase: adhP phosphate NarK benzoquinol iscS thiF nudB acetaldehyde dhaL dhaM biosynthesis I (Gram- 3-hydroxypimeloyl- 2-naphthoate diphosphate dehydrogenase: Amine and Polyamine Degradation aldA nitrate nitrate hydroxylase: a [ThiI sulfur- a carboxy- negative bacteria) [acp] methyl ester 7,8-dihydroneopterin pdxB pantothenate 6 SecA glt carrier protein]-S- adenylated-[ThiS acetaldehyde DHAP 5,10- a 2-thiouridine 34 1,N - 2457 2552 galactitol 1- a negatively α-D-mannose nitrite NarK nitrite ubiF glycolate lipid A-core a peptidoglycan β-D-glucose maltohexaose maltose lactulose (2E,6E)-farnesyl UTP uridine uridine (R)-2- choline dehydratase: fabZ 1,4-dihydroxy- sulfanyl-L-cysteine sulfur-carrier protein] 3'-phosphate 2-oxo-3-hydroxy-4- synthetase: panC a phosphatidylethanolamine 2-oxoglutarate ethenoadenine maltohexaose c-di-GMP (S)-5-hydroxyisourate hydroxypyruvate pyrazinamide L-dopa DNA with lesion Ins(1,2,3,4,5,6)P (R)-NADHX glutathione allantoin degradation dehydrogenase: methylenetetrahydrofolate in tRNA diphosphate protoheme IX in 23S rRNA in 23S rRNA hydroxyglutarate phosphate supercoiled DNA 1-phosphate 6 phosphobutanoate superpathway of N-acetylglucosamine, 4-aminobutyrate ethanolamine UTP N-acetylglutamate a (2E)-enoylpimeloyl- 2-naphthoate 3-demethylubiquinol-8 IV (anaerobic) glycolate mhpF in DNA c-di-GMP 23S rRNA 2'-O 2-oxoglutarate hydroxypyruvate galactitol-1- topoisomerase: sugar Nucleotide NADHX N-acetylmannosamine and N- degradation II utilization pyrophosphatase: yhdE 23S rRNA [acp] methyl ester octaprenyltransferase: carboxy-adenylated- phosphodiesterase: 5-hydroxyisourate 2457 -ribose U2552 reductase: ghrB phosphate 5- pyrazinamidase: 4,5-DOPA excision synthase: argA phosphohydroxythreonine (R)-pantothenate dehydrogenase: [+ 2 isozymes] lysozyme: lactulose pseudouridine reductase ((R)-2- topA phosphatase: epimerase: acetylneuraminate degradation 5-aminomethyluridine- 6 amylomaltase: nitrite NirC nitrite menA 3-demethylubiquinone- [ThiS sulfur- (S)-(+)-allantoin phosphoethanolamine 1,N - amylomaltase: heme O dosP nucleoside triphosphate hydrolase: hiuH methyltransferase: hydroxyglutarate- hydroxypyruvate dehydrogenase: topoisomerase: pncA dioxygenase yigL repair: uvrB betaine aldehyde enoylpimeloyl- D-glyceraldehyde aminotransferase: serC ethanolamine glcD glcF glcE rrrD galactohydrolase: synthase: rluE nnr N-acetyl-L- 8 3-O- carrier-protein] chorismate N-acetylneuraminate 4-aminobutanoate acetyl-CoA transferase: eptC tRNA synthase: malQ malQ pyrophosphohydrolase: extradiol: ygiD MreB [acp] methyl ester 7,8-dihydroneopterin ethenoadenine synthase: [+ 4 isozymes] (S)-2-oxo-4- 2457 rlmE forming): serA reductase: ghrA gatD topB [+ 3 isozymes] uvrC uvrA D-myo-inositol 3-phosphate 4-phospho- pantothenate kinase: coaA 4-aminobutyrate ethanolamine mnmE mnmG [+ 2 isozymes] lacZ a pseudouridine a 2'-O- keto-D-tagatose pyrazine-2- glutamate betaine aldehyde methyltransferase: ubiG sulfurtransferase: thiI allantoinase: N-acetylneuraminate glyoxylate repair: alkB cyoE mazG hydroxy-4-carboxy- DNA without (S)-NADHX GSSG reductase: fabI tyr 4-amino-4- hydroxy-L- linear dimeric GMP 2552 2-oxoglutarate D-glycerate a relaxed DNA carboxylate 4,5-seco-dopa D-mannose (1,2,3,4,5)- demethylmenaquinol-8 1-deoxy-D- D-glyceraldehyde aminotransferase: ammonia- in 23S rRNA methyluridine 6-phosphate lesion nitrite nitrite dehydrogenase: adenylate:persulfide dihydroneopterin pyruvate allB lyase: nanA lipid A-core- UMP 5-ureidoimidazoline pentakisphosphate acetylglutamate ubiquinol-8 xylulose-5- deoxychorismate 3-phosphate threonine N-acetyl-D- puuE lyase: eutB eutC a 1,2-diacyl- N-acetyl-D- a N-acetylmuramoyl- β in 23S rRNA betB a pimeloyl-[acp] methyl ester transferase: thiF aldolase: folB D-4'-phosphopantothenate a 5-(aminomethyl)-2- maltopentaose maltose maltoheptaose -D-glucose D-fructofuranose β-D-galactose NarU kinase: argB demethylmenaquinone 2-iminoacetate synthase: mannosamine acetaldehyde glyoxylate malate phosphoethanolamine sn-glycerol 7,8-dihydrofolate phosphate allantoate allantoin degradation 34 glyoxal an adenine in DNA succinate glucosamine pentapeptide- 4-aminobutyrate (hep II) thiouridine in tRNA heme o nitrate nitrate glycine betaine methyltransferase: ubiE synthase: thiH synthase: dxs 6-hydroxymethyl- pabB pabA 1-deoxy-D- carboligase: synthase diphosphoundecaprenol pimeloyl-[acp] phosphopantothenoylcysteine N-acetylmannosamine to glyoxylate III transaminase: 2+ 2+ YojI N-acetylglutamyl- AIR a thiocarboxy- 7,8-dihydropterin allantoate gcl G: glcB glycerol and glycerophosphodiester degradation Zn ZntA Zn methyl ester 1-deoxy-D-xylulose 4-amino-4- xylulose-5- synthetase: dfp kinase: nanK gabT phosphate menaquinol-8 2-iminoacetate (2S)-2-amino-3-oxo-4- succinate 5-phosphate [ThiS-Protein] 2-amino-4-hydroxy-6- deoxychorismate phosphate amidohydrolase: N-acetyl-D- (S)-(+)-allantoin malate esterase: bioH molybdenum cofactor biosynthesis phosphonooxybutanoate core oligosaccharide-lipid A (E. a 5-[(methylamino)methyl]- a pyrimidine nucleoside a 23S rRNA a guanine 1207 adenine 1618 a uridine 2604 a cytidine 34 (S)-2- (S)-2- D-glucosamine D-mannitol a 2'- phosphomethylpyrimidine hydroxymethyldihydropteridine synthase: allC semialdehyde tartronate synthase glycerol a 1-palmitoyl-2-acyl- isoprimeverose + N-acetylglutamylphosphate R-4'-phosphopantothenoyl-L-cysteine mannosamine allantoinase: 34 selenophosphate L-carnitine glycerophosphoglycerol 1911/1915/1917 hydroxypyruvate a quinone thiosulfate deoxyribonucleoside 3',5'-ADP protoheme IX Cu synthase: thiC aminodeoxychorismate coli K-12 core type) (no GlcNAc) phosphatidylglycerol 2-thiouridine in tRNA an [oxidized DsbD protein] thr uridine in 16S rRNA in 23S rRNA in 23S rRNA in tRNA hydroxyglutarate hydroxyglutarate 6-phosphate 1-phosphate reductase: argC a pimeloyl-[acp] diphosphokinase: folK dxs 6-phosphate succinate semialdehyde A: aceB a glycerophosphodiester ATP 2+ 2+ 1-deoxy-D-xylulose lyase: pabC allB 23S rRNA 2 6 tRNA (cytidine- 2-oxoglutarate L-2- quinone sugar mannitol-1- 3'-monophosphate Zn ZitB Zn (2-amino-4-hydroxy- S-ureidoglycine semialdehyde thiol-disulfide 16S rRNA m G1207 23S rRNA m A1618 23S rRNA thiosulfate 3'(2'),5'- heme d N-acetyl-L- 5-phosphate:thiol cys 4'-phosphopantothenoylcysteine N-acetylmannosamine- tartronate 1911/ hydroxypyruvate YagU a small subunit of allantoate glycerol ribosylpyrimidine exchange: dsbD pseudouridine 2604 2'-O)-ribose reductase ((S)-2- hydroxyglutarate oxidoreductase, sulfurtransferase: phosphatase: phosphatase: synthase: HMP-P 7,8-dihydropteridin-6- 1-deoxy-D- 3-amino-1- dehydrogenase isoprimeverose methyltransferase: methyltransferase: pseudouridine bisphosphate glutamate 5- 8-amino-7- sulfurtransferase: molybdopterin 4-aminobenzoate decarboxylase: dfp (S)-ureidoglycine 6-phosphate semialdehyde glycerophosphodiester kinase: tRNA 2- carnitine--CoA glycerophosphoglycerol nucleosidase: rihB 1915/1917 methyltransferase: hydroxyglutarate- dehydrogenase: isomerase: hyi NADPH- yigL hxpB yl)methyl diphosphate xylulose 5- hydroxyacetone (NADP + ): gabD (S)-malate thioredoxin:disulfide α rsmC rlmF synthase: rluF glpE nucleotidase: katE semialdehyde oxononanoate thiG L-cysteine:[protein aminohydrolase: epimerase: nanE allantoate reductase: glxR selenouridine -xylosidase: yicI threonylcarbamoyl- 2 6 phosphomethylpyrimidine synthase phosphodiesterase: ugpQ glpK ligase: caiC phosphodiesterase: ugpQ synthase: rluD an N - an N - 2604 trmL forming): serA lhgD dependent: qor [+ 3 isozymes] [+ 4 isozymes] cysQ 2+ phosphate 1-phosphate 4'-phosphopantetheine N-acetyl-D- oxidoreductase: trxA 1911/ a pseudouridine a 2'-O- tartronate 2+ 2+ Zn ABC 2+ N-acetylornithine synthase: bioF cysteine] molybdopterin- allE amidohydrolase: tartronate synthase: selU AMP synthase: tsaC a pseudouridine 1207 1618 sulfite a 2'- heme d Cu Zn Zn kinase: thiD dihydropteroate succinate methylguanine methyladenine in 23S rRNA 34 2-oxoglutarate 2-oxoglutarate semialdehyde a semiquinone D-glucosamine D-mannitol AMP transporter aminotransferase: 2-[(2R,5Z)-(2-carboxy- sulfurtransferase: synthase glucosamine allC semialdehyde a pyrimidine base a [reduced DsbD protein] 1915/1917 in 23S rRNA methylcytidine deoxyribonucleoside synthase: folP pantetheine-phosphate sn-glycerol a hepta-acylated core D-ribofuranose in 16S rRNA in 23S rRNA astC 8-amino-7-oxononanoate 4-methylthiazol-5(2H)- iscS adenylyltransferase: pyridoxine pyridoxine 5'- S-ureidoglycolate 6-phosphate reductase: garR β-D-glucose α-D-xylopyranose in tRNA HMP-PP 3-phosphate a 1-lysophosphatidylglycerol oligosaccharide lipid a 5-methylaminomethyl-2- AMP L-carnitinyl-CoA glycerol sn-glycerol YcjF ylidene]ethyl phosphate phosphate adenylyltransferase: coaD N-acetylglucosamine- S-ureidoglycine unknown product diphosphate (L-threonylcarbamoyl) [+ 2 isozymes] 7,8- L-cysteine moeB selenouridine 34 in tRNA 3-phosphate ureidoglycolate Fatty Acid and A (E. coli K-12 type) 2+ Zn 2+ hydrogen desulfurase: a carboxy- 7,8-dihydropteroate synthase: pyridoxamine 6-phosphate D-glycerate aerobic glycerol adenylate Zn ZntB N-acetyl-L- diaminopelargonic pyridoxine 3'-dephospho-CoA dehydrogenase: (S)-ureidoglycine Lipid Degradation carbonate thiamine sufS adenylated pdxJ deacetylase: nagA 3-phosphate ornithine acid synthase: bioA kinase: pdxK allD aminohydrolase: phenylethylamine phosphate pyridoxal D-glucosamine 6 carbamoyl [small subunit of dihydrofolate pyridoxamine dehydrogenase: α-D-ribose-1- a 2'- 2445 1402 2605 an N -L- 55 a 3-dehydro- an S-sulfanyl- dephospho-CoA allE degradation I fatty acid β-oxidation I glucosyl-(heptosyl) - UDP-α-D-glucuronate a [protein]- a DNA methyl a 5-carboxymethylaminomethyl- a guanine a cytidine uridine sn-glycerol a uridine D-sorbitol acetylornithine synthase: thiE 6-phosphate 3 glutathione GS-methylhydroquinone hydroxymethylpyrimidine 2-oxoglutarate glutarate 37 thiamin chitin phosphate 7,8-diaminopelargonate molybdopterin synthetase: folC kinase: pdxK glpD 34 DMAPP methylphosphonate- deoxyribonucleoside threonylcarbamoyladenine Ins(2)P a sugar phosphate DHAP Ap4A D-guloside diacetyl YqhA NAD biosynthesis [L-cysteine pyridoxine kinase: coaE oxalurate Kdo -lipid A-phosphate L-cysteine phosphotriester 2-thiouridine in tRNA in 23S rRNA in 16S rRNA in 23S rRNA 3-phosphate in tRNA 6-phosphate synthetase: deacetylase: synthase] S-ureidoglycolate 2 3-dehydro- YdcO desulfurase] 5'-phosphate pyridoxamine 3-phospho- hydroxymethylpyrimidine dimethylallyl diphosphate 5-triphosphateα-D-ribose-1- 5'-monophosphate 23S rRNA m 2 G2445 16S rRNA m 4 C1402 23S rRNA in tRNA tRNA sugar sorbitol-6- thiamine diacetyl argE I (from aspartate) 7,8-dihydrofolate pyridoxal 2-phenylethylamine a (3Z)-alk-3-enoyl-CoA DHAP deoxyribonucleoside L-glyceraldehyde inositol diadenosine carB carA dethiobiotin D-glycerate 2605 55 methylglyoxal D-guloside 4- thiamin phosphate kinase: 5'-phosphate coenzyme A UDP- S-glutathionyl- kinase: thiD pyrophosphatase: nudJ methylphosphonate- methyltransferase: methyltransferase: pseudouridine pseudouridine phosphatase: phosphatase: kinase: reductase: synthetase: bioD phenylethylamine methylphosphotriester- 5-aminomethyl- glutarate 2- 5'-monophosphate 3-phosphate monophosphatase: synthase: mgsA tetraphosphatase: epimerase: carbamoyl- molybdopterin α-D-glucosamine ureidoglycolate hydroxymethylpyrimidine dimethylallyl diphosphate hxpA hxpB thiK dihydrofolate pdxY pyridoxine 5'- oxidase: tynA ∆ 3 2 glucuronate:LPS(HepIII) hydroquinone 5-triphosphate rlmL rsmH synthase: rluB reductase: gpr suhB synthase: truB apaH ucpA L-ornithine asp GTP lyase: allA -cis-∆ -trans- DNA-protein-cysteine S 2-thiouridine hydroxylase: phosphatase: yfbR 2 4 ycjR thiamine synthase kinase: pdxK an N - an N - 2605 6 55 phosphate reductase: folM pyridoxal phosphate pyridoxamine 6-phosphate glycosyltransferase: waaH reductase: yqjG pyrophosphatase: nudF α-D-ribose-1-diphosphatase: phnM a pseudouridine a cyclic N -L- L-glyceraldehyde a pseudouridine [+ 3 isozymes] [+ 4 isozymes] a 3-dehydro- a chitodextrin dethiobiotin NAD salvage pathway I formylTHF biosynthesis phenylacetaldehyde enoyl-CoA methyltransferase: ada synthase: mnmC glaH a 2'- 2445 1402 methylglyoxal (S)-acetoin L-aspartate monophosphate sulfurtransferase: HMP-P methylguanine methylcytidine myo-inositol ADP thiamin phosphate RclC dihydrofolate kinase: oxidase: 5'-phosphate carbamoyl- oxamate glucosamine- glyoxylate prenyl phosphate methylphosphonate deoxyribonucleoside in 23S rRNA threonylcarbamoyladenosine 3-phosphate in tRNA a sugar D-sorbitol D-glucoside oxidase: nadB kinase: thiL ynjE GTP 3',8'- isomerase: fadB oleate β-oxidation in 23S rRNA in 16S rRNA ornithine biotin reductase: folA pdxK pdxH oxidase: pdxH 5-formyl- phosphate 6-phosphate phenylacetaldehyde 5-phosphate 37 in tRNA YbhQ NAD + α-iminosuccinate cyclase: dodecenoyl-CoA glucosyl-(heptosyl) -glucuronosyl- UDP methyl-p- a [protein]-S- a 5-(aminomethyl)-2- (S)-2- carbamoyltransferase: tetrahydrofolate deaminase: 3 GSSG [DNA] glyoxylate succinate synthase: bioB thiamin diphosphate a thiocarboxylated moaA carbamate dehydrogenase: feaB Kdo -lipid A-phosphate 34 tetrahydrofolate D-isomerase: fadJ 2-trans,5-cis- 2 hydroquinone methyl-L-cysteine thiouridine in tRNA hydroxyglutarate argI quinolinate [small subunit of cyclic kinase: ybcF nagB 3-hydroxyacyl- PLP tetradecadienoyl-CoA biotin synthase: molybdopterin pyranopterin carbamate phenylacetate adenosylcobalamin salvage from cobinamide I F6P a (2E)-2-enoyl-CoA CoA 1835 2030 747 46 38- 65 YjiJ nadA synthase] phosphate kinase: epimerase: fadB ∆ 3 ∆ 2 core oligosaccharide-lipid A (E. DNA containing hydrogen (S)-3-hydroxy-(9Z) adenine 1518 / a guanine adenine a uracil a guanine a uridine a uridine β-D-fructofuranose thymine β-D-glucose a single L-citrulline enoyl-CoA -cis- -trans- cellulose a phosphatidylethanolamine a 1-palmitoyl-2-acyl- menadiol glutarate semialdehyde γ-butyrobetaine a phosphatidylglycerol a ribonucleoside methylglyoxal L-tartrate acryloyl-CoA 4-hydroxyphenylacetatecellulose HpaX 4-hydroxyphenylacetate NMN ECB_03712 3-hydroxybutyryl- hydratase: enoyl-CoA coli K-12 core type) (no GlcNAc) phosphatidylserine a base with lesion peroxide -hexadecenoyl-CoA adenine 1519 in 16S rRNA in 23S rRNA in 23S rRNA in 23S rRNA in tRNA 40 in tRNA 5'-monophosphate in tRNA 1-phosphate thymine 6-phosphate stranded DNA quinolinate cobinamide enoyl-CoA 6 molybdopterin predicted 3-hydroxyacyl-CoA glutarate-semialdehyde 16S rRNA m lipid 23S rRNA m 2 G1835 23S rRNA m 6 A2030 23S rRNA m 5 U747 tRNA m 7 G46 tRNA tRNA fructose-1- sugar L(+)-tartrate acrylyl-CoA DNA CoA a 2,3,4-saturated (3R fadJ isomerase: 2 5'-nucleotidase: oxygenase: 5-formyltetrahydrofolate CO hydratase: fadJ 6 65 methylglyoxal argininosuccinate synthase: 2 enoyl-CoA dehydrogenase: fadJ dehydrogenase: sad A1518,m A1519 38- phosphatase: phosphatase: quinolinate cobinamide short chain epimerase: fadJ fadB celulose DNA containing a menadiol:hydrogen 2 γ-butyrobetaine kinase: methyltransferase: methyltransferase: methyltransferase: methyltransferase: pseudouridine umpG pseudouridine rutA dehydratase: reductase: primase: synthase: argG cyclo-ligase: fau a 2,3,4-saturated fatty acid )-3-hydroxyacyl-CoA enoyl-CoA glutarate-semialdehyde yqaB reductase: ydjG yigL tellurite ActP tellurite phosphoribosyltransferase moaE moaD acyl-CoA reductase: ydiO enoyl-CoA phosphoethanolamine 3-hydroxyacyl-CoA dimethyltransferase: yegS rlmG rlmJ rlmC trmB 40 synthase: truA synthase: truC (Z)-2- ttdB ttdA yhdH dnaG adenosyltransferase: tetrahydrofolate hydratase: base with lesion peroxide monooxygenase: 2 6 7 [+ 2 isozymes] CheZ hydratase: fadB dehydrogenase: fadB dehydrogenase: gabD rsmA an N - an N - 747 an N - 38- 65 L-arginino- (decarboxylating): nadC btuR synthetase: fadK acyl-CoA 3-trans,5-cis- transferase: bcsG hydrolase: mug oxidoreductase: ccp N 6 -dimethyladenine 1518 yeaW yeaX a 5-methyluracil a pseudouridine a pseudouridine [+ 4 isozymes] methylureidoacrylate [+ 3 isozymes] a short RNA a cellodextrin fadB a phosphatidylglycerophosphate 1835 2030 46 acetol oxaloacetate propanoyl-CoA 6 1519 methylguanine methyladenine methylguanine a ribonucleoside β β succinate nicotinamide molybdopterin [+ 2 isozymes] a 2,3,4-saturateddehydrogenase: a 2,3,4-saturated (3S tetradecadienoyl-CoA 3-oxo-(9Z)-hexadecenoyl-CoA glutarate /N -dimethyladenine in 23S rRNA 40 in tRNA in tRNA -D-fructofuranose peracid -D-glucose segment NaMN in 23S rRNA in 23S rRNA in tRNA adenosylcobinamide dihydrofolate methionine Polymeric Compound Degradation fatty acyl CoA fadE )-3-hydroxyacyl-CoA3-hydroxyacyl-CoA phosphoethanolamine a hepta-acylated core in 16S rRNA magnesium hydrogenphosphate magnesium hydrogenphosphate argininosuccinate NMN 3-hydroxy-5-cis- acyl-CoA a 1,2-diacyl- a 1-lysophosphatidylserine a DNA containing an succinate nicotinamidase: molybdopterin reductase: folM synthase: dehydrogenase: cellulose oligosaccharide lipid base with lesion menadione H O trimethylamine calcium hydrogenphosphate calcium hydrogenphosphate lyase: argH nicotinate- gcv system: tetradecenoyl-CoA thioesterase: sn-glycerol 2 PitA amidohydrolase: pncA cobinamide adenylyltransferase: metH 5,10-methylenetetrahydrofolate:glycine A (E. coli K-12 type) apurinic/apyrimidinic site semialdehyde zinc hydrogenphosphate zinc hydrogenphosphate mononucleotide dihydrofolate gcvT gcvH glycogen degradation I fadB fadM HokA pncC kinase: cobU mog hydroxymethyltransferase: glyA [+ 2 more] [+ 2 more] adenylyltransferase: 5,6-dimethylbenzimidazole NaMN dihydrofolate reductase: folA gcvP lpd coenzyme A 3-hydroxyacyl-CoA (3E,5Z)- arg nicotinate adenosyl- molybdopterin lys nadD synthetase: folC dehydrogenase: tetradecadienoate α-D-glucopyranosyl- UDP-N-acetyl- (S)-3-hydroxy-(7Z) a 5-(aminomethyl)-2- a guanine 1516 a guanosine 18 2,6- a guanine 37 7,8- a uridine 13 D-ribose 5- α-D-glucose N-acetyl-α- L-ornithine cobinamide adenine folate polyglutamylation 5-methyl- a glycogen glycerophosphoglycerol a 1-lysophosphatidylethanolamine GDP-β-L-fucose glutathione (7Z)-hexadecenoyl-CoA L-carnitine 2,3- 4-hydroxybutanoate isobutanal 8-oxo-dGTP D-tartrate nitric oxide ATP 7,8-dihydropteroate α-D-glucosamine 34 arginine nicotinate nicotinate adenine 7,8-dihydrofolate acetyl-CoA C- fadJ diphosphoundecaprenol -hexadecenoyl-CoA thiouridine in tRNA diaminopropanoate in 16S rRNA in tRNA dimethoxyphenol in tRNA dihydroneopterin in tRNA phosphate 6-phosphate neuraminate nicotinate- phosphate dinucleotide tetrahydrofolate 3-hydroxyacyl-CoA acyl-CoA ModF lysine decarboxylase, glycogen a 2,3,4-saturated acyltransferase: a 2,3,4-saturated 5-methylaminomethyl- 16S rRNA m 2 G1516 tRNA (Gm18) 2'-O- tRNA m 1 G37 succinate tRNA sugar isobutyraldehyde 8-oxo-dGTP sugar D-tartrate nitric oxide adenylate acyl carrier protein phosphoribosyltransferase: dinucleotide nucleotide--dimethylbenzimidazole cobinamide-P molybdopterin 2,3- dihydroneopterin ornithine tetrahydrofolate phosphorylase: fadI dehydrogenase: fadJ dehydrogenase: fadE 2-thiouridine-forming 13 phosphatase: phosphatase: decarboxylase: degradative: adiA pncB + + phosphoribosyltransferase: cobT molybdotransferase: thymidylate fatty acyl CoA 3-oxoacyl-CoA fucosyltransferase: N-acetylglucosaminyltransferase: glutathione-specific γ- carnitine methyltransferase: methyltransferase: methyltransferase: semialdehyde pseudouridine reductase: ybbO diphosphatase: dehydratase: dioxygenase: cyclase: YhjK metabolism I NAD NAD guanylyltransferase: glycerophosphoglycerol methyltransferase: diaminopropionate epimerase: folB SAM ldcC decarboxylase: glgP 3-ketoacyl-CoA wcaI 3-hydroxyacyl-CoA predicted enoyl- rsmJ trmH trmD reductase: yihU synthase: truD yigL [+ 3 isozymes] mutT yigL fumB hmp cyaA synthetase, synthetase, cobU moeA synthase: thyA pgaD pgaC glutamylcyclotransferase: monooxygenase: ammonia-lyase: ygeX 2 1 β agmatine acyltransferase: pldB mnmC an N - a 2'-O- an N - 13 N-acetyl- - lysine speF NaMN MoO - 5,10-methylenetetrahydrofolate:glycine thiolase: fadA dehydrogenase: fadB CoA reductase: ydiO a 5-[(methylamino) 3,3',5,5'- 7,8- succinate a pseudouridine [+ 3 isozymes] [+ 3 isozymes] glutamine NH - α-ribazole 2 an α-limit dextrin chaC yeaW yeaX 1516 18 37 acyl-carrier protein 3 adenosylcobinamide- 5,10- pyruvate methylguanine methylguanosine methylguanine isobutanol 8-oxo-dGMP α oxaloacetate nitrate cyclic-AMP neuraminateD-fructosyl- D-fructosyl- decarboxylase: ornithine molybdopterin hydroxymethyltransferase: glyA 3-oxo-(7Z)-hexadecenoyl-CoA (2E,7Z)-hexadecenoyl-CoA methyl]-2- tetramethoxydiphenoquinone dihydromonapterin semialdehyde in tRNA aldehydo-D-ribose -D-glucose FrlA nicotinate- dependent: dependent: 5'-phosphate GDP β in 16S rRNA in tRNA in tRNA cadA agmatinase: decarboxylase: cofactor methylenetetrahydrofolate methylenetetrahydrofolate α-L-fucosyl-(1->3)- poly- -1,6- UDP thiouridine 34 in tRNA L-lysine L-lysine mononucleotide nadE nadE 10-formyl- α GDP speC a tetrahydrofolate reductase: metF dehydrogenase: folD limit dextrin -1,6- L-1-glycerophosphorylethanolamine a lysophosphatidylglycerol β-D-glucopyranosyl- N-acetyl-D- L-malic NrfE speB 5,10- tetrahydrofolate 5,10- 5,10- 5-oxo-L-proline L-cysteinyl-glycine trimethylamine dAdoMet cadaverine adenylyltransferase: + cobalamin 5'- glucohydrolase: glucosamine semialdehyde holo-[acyl-carrier- NAD methylenetetrahydrofolate methylenetetrahydrofolate methenyltetrahydrofolate diphosphoundecaprenol nadD phosphate γ glgX acetyl-CoA protein] synthase: acpS folylpoly- - pseudouridine PsuT pseudouridine putrescine synthase: glutathione biosynthesis methenyltetrahydrofolate lipoate glutamate 6 holo-[acyl carrier nicotinate adenine dinucleotide S-adenosyl-L-methionine cycle I a debranched a partially deacetylated poly-β- (S)-3-hydroxy-(7Z) an N -L- 4-nitrobenzyl a guanine 2069 adenine 37 D-glucose 6- a double cobS synthetase: cyclohydrolase: folD lipid IV 1,2-dipalmitoyl- 32 2+ 3'-UMP biosynthesis and 10 maltotetraose quercetin a phosphatidylethanolamine a 5'-phosphopolynucleotide ATP palmitoleoyl-CoA 37 A trans-aconitate putrescine 5-aminopentanal cyclic-AMP a tRNA uridine DHAP a phenol sulfate 8-oxo-dGDP (S)-NADPHX Fe protein] synthase: acpT an N - α-limit dextrin 1,6-N-acetyl-D-glucosamine I -tetradecenoyl-CoA threonylcarbamoyladenine phosphatidylserine alcohol in 23S rRNA in tRNA val phosphate stranded DNA aminopropylcadaverine NAD + synthetase, a 5,10- folC 10-formyl- 1 spermidine incorporation I formyltetrahydrofolate 3-hydroxyacyl-CoA acyl-CoA in tRNA 7 6 sugar sugar an L- an L- RsxE cys glt glutathionylspermidine 6 6 4-nitrobenzaldehyde 23S rRNA m G2069 trans-aconitate 2- diamine N- tRNA m A37 5-aminopentanal cAMP tRNA acrylsulfatase- 8-oxo-dGDP (S)-NADPHX synthase: speE glutamine SAM adenosylcobalamin methylenetetrahydrofolate tetrahydrofolate tRNA m t A37 gyrase: ferroxidase: LysO synthase: 10-formyl- maltodextrin dehydrogenase: fadJ dehydrogenase: fadE 32 phosphatase: phosphatase: amino acid amino acid 5'-phosphate an octanoyl-[acp] a tetrahydrofolate biosynthesis reductase: dkgB methyltransferase: methyltransferase: acetyltransferase: methyltransferase: dehydrogenase: phosphodiesterase: pseudouridine like enzyme: diphosphatase: dehydratase: speE dependent: nadE methylene- quercetin 2,3- DNA 5' adenylyl methyltransferase: yigL gyrA gyrB bfr an acyl-carrier protein tetrahydrofolylpolyglutamate phosphorylase: 3-hydroxyacyl-CoA predicted enoyl- [+ 4 isozymes] rlmL tam speG yfiC patD cpdA synthase: rluA aslA mutT yigL nnr octanoyl tetrahydrofolylpolyglutamate formyltetrahydrofolate trmO 7 6 + methionine adenosylcobalamin glutamate--cysteine synthetase: folC malP Amino Acid Degradation dioxygenase: yhhW transferase: rtcA dehydrogenase: fadB CoA reductase: ydiO an N 6 -methyl- an N - (E)-3- an N - 32 [+ 3 isozymes] [+ 3 isozymes] uridine NAD transferase: glutathione spermidine superpathway of arginine and ornithine degradation a pseudouridine a negatively 3+ S-methyl-5'- 5'-phosphate ligase: gshA synthetase: folC deformylase: purU superpathway of threonine metabolism arginine degradation 4-nitrobenzaldehyde methylguanine 2069 (methoxycarbonyl) N-acetylputrescine methyladenine 37 5-aminopentanoate AMP a phenol 8-oxo-dGMP NADPH Fe glycine glycine aminopropylcadaverine spermidine adenosyltransferase: a [lipoyl-carrier 10 3-oxo-(7Z)-tetradecenoyl-CoA (2E,9Z)-hexadecenoyl-CoA threonylcarbamoyladenosine in tRNA dihydroxyacetone D-glucose supercoiled DNA copper/ ProP lipB an N - val thioadenosine phosphatase: cobC 6 α-D-glucose II (AST pathway) in 23S rRNA pent-2-enedioate in tRNA betaine betaine metK protein] N - a 5,10- a partially deacetylated a partially deacetylated 37 in tRNA 2-palmitoyl- 1 + silver + γ formyltetrahydrofolate glutathionylspermidine maltotriose a 5' adenylylated lipid IV Ag Ag L- - methylenetetrahydrofolate NAD phosphorylation and dephosphorylation I formate 1-phosphate arg 2-protocatechuoylphloroglucinolcarboxylate poly-β-1,6-N-acetyl-D- β a 1-lysophosphatidylethanolamine a fatty acid sn-glycero-3- B + + met SAH coenzyme B octanoyl-L-lysine tetrahydrofolate thr carbon monoxide poly- -1,6-N-acetyl-D- Cu export Cu 12 glutamylcysteine synthetase: gss polynucleotide lipoyl phosphoglucomutase: maltotriose arg glucosamine (fragment 1) glucosamine (fragment 2) phosphoserine system glycine glycine cytidylyl molybdenum L-ornithine BetU guanylyl molybdenum glutathione synthase: + + + glucosidase: arginine decarboxylase, betaine betaine cofactor biosynthesis NADP NADH NAD NADP pgm cofactor biosynthesis S-adenosylhomocysteine synthetase: malZ arginine N- lipA glutathionylspermidine degradative: adiA threonine 4-hydroxy-2,3- 1407 955/2504/ 746 516 35 threonine 6 + + MoO - α-D-glucose a dimer of adjacent 2'- an N -(1-hydroxy-2- (S)-3-hydroxy-(9Z) a cytosine uridine 7 uridine a uridine a uridine D-glyceraldehyde a 1,2-diacyl- D-mannose 2,3- 2 cobalamin-independent nucleosidase: mtn a [lipoyl-carrier ν a β-D glucoside L-idonate 2'CMP Cu CopA Cu MoO - gshB menaquinol-8 biosynthesis NAD dehydrogenase: deaminase: succinyltransferase: 3-mercaptopyruvate hydrogen cyanide a double stranded DNA h (S)-3-hydroxybutanoyl-CoA pentanedione a [protein]-L-histidine spermine m GTP reduced riboflavin phosphocholine molybdopterin 2 6 6-phosphate maltose ornithine deoxycytidines in DNA oxopropyl)-[protein]-L-lysine -octadecenoyl-CoA in 16S rRNA 2580 in 23S rRNA in 23S rRNA in 16S rRNA in tRNA 3-phosphate sn-glycerol 6-phosphate dihydroxybenzoate molybdopterin homocysteine protein]-N -[(R pyridine nucleotide kinase: agmatine threonine astA tdh ilvA 3-hydroxyacyl-CoA 3-hydroxyacyl-CoA 5-phosphate 5 23S rRNA protein-histidine 7 Tyr sugar L-idonate 5- sugar glycine cofactor molybdenum cofactor transmethylase: metE glutathione )-lipoyl]-L-lysine transhydrogenase: decarboxylase: speF 16S rRNA m C1407 diamine N- m GTP 23S rRNA 16S rRNA tRNA riboflavin cofactor molybdenum cofactor L-homocysteine S-ribosyl-L-homocysteine nadK amylomaltase: aldolase: L-threonine 3- N 2 -succinyl- dehydrogenase: fadJ dehydrogenase: fadJ (4S)-4-hydroxy-5- 955/ pros-kinase: cusS diacylglycerol glycine betaine ABC glycine cytidylyltransferase: demethylmenaquinol-8 L-threonine threonine methyltransferase: pseudouridine acetyltransferase: pyrophosphatase: pseudouridine 746 pseudouridine 516 pseudouridine 35 phosphatase: dehydrogenase: phosphatase: reductase: pntB pntA NAD + ornithine ltaE phosphonooxypentane- a long-chain a long-chain guanylyltransferase: + malQ O-phosphate L-arginine 3-mercaptopyruvate:cyanide 5' to 3' exonuclease: polA deoxyribodipyrimidine protein deglycase: yajL 2504/2580 kinase: dgkA betaine transporter, non- betaine cytidylyl mocA demethylmenaquinone NADP agmatinase: speB decarboxylase: speC dehydrogenase: dehydratase: 3-hydroxyacyl-CoA 3-hydroxyacyl-CoA rsmF protein-histidine speG yceF synthase: rluA synthase: rsuA synthase: rluF yigL idnD yigL fre FadL guanylyl mobA 2,3-dione isomerase: lsrG 7 fatty acid fatty acid osmoregulatory molybdenum yiaY tdcB sulfurtransferase: sseA DNA exonuclease: recE photolyase: phr protein deglycase: yhbO dehydrogenase: fadB dehydrogenase: fadB 1407 synthase: rluC pros-kinase: cpxA N - 746 35 [+ 3 isozymes] 5-dehydro- [+ 3 isozymes] cytidine methyltransferase: ubiE 2-amino-3- N-succinylarginine 3-hydroxy-2,4- a 5-methylcytosine 955/ π 1 a pseudouridine a 16S rRNA a pseudouridine molybdenum + D-glucopyranose a pseudouridine a [protein]-N - NAD NADPH N -acetylspermine methylguanosine 516 a phosphatidate riboflavin 2-carboxymuconate choline cofactor S-ribosylhomocysteine ketobutyrate dihydrolase: astB 3-oxo-(9Z)-octadecenoyl-CoA acetoacetyl-CoA pentadione in 16S rRNA in 23S rRNA pseudouridine in tRNA D-glyceraldehyde D-gluconate D-mannose cofactor menaquinol-8 putrescine 2504/2580 in 23S rRNA phospho-L-histidine (2Z)-2-aminobut- 5-phosphate a non 5'-phosphate lyase: luxS CoA ligase: kbl 2-amino-3- (R)-1-amino- N 2 -succinyl- two adjacent 2'- β-D-glucose acetaldehyde thiocyanate (R)-lactate a [protein]-L-lysine glucosylated D- sn-glycerol 3-phosphate YbiT gly oxobutanoate 2-enoate pyruvate a 5'-phosphomononucleotide a single stranded DNA 2-propanol O L-ornithine deoxycytidines in DNA glucose acceptor a glycerophosphodiester / glycerophosphodiester a glycerophosphodiester acetaldehyde β-D-glucose glutamate-putrescine -2-phosphate succinylornithine ABC transporter dehydrogenase: ligase: puuA transaminase: astC mhpF a [DNA]- 1915 1962 γ glucokinase: 2 + a dimer of adjacent (S)-3-hydroxy-(5Z) a pseudouridine a cytosine a 5' diphospho- a cytidine an aliphatic -butyrobetainyl- a ribonucleoside an aliphatic α 2'-UMP N -succinyl- a 2-lysophosphatidylethanolamine (deoxynucleotides) NAD [DNA] glycerol a phosphatidylethanolamine hν (7Z)-tetradecenoyl-CoA 1,3-propanediol crotonyl-CoA shikimate D-mannopyranose -ribazole (S)-NADHX (R)-NADPHX dodecyl sulfate L-carnitine L-carnitine glk [+ 2 isozymes] 2-iminobutanoate (m) thymidines in DNA -dodecenoyl-CoA nucleotide- in 23S rRNA in 23S rRNA [mRNA] 32 in tRNA α,ω-diamine CoA 3'-phosphate α,ω-diamine 5'-phosphate YhjV aminoacetone L-glutamate 5- γ 3-hydroxyacyl-CoA acyl-CoA 3'-phosphate 23S rRNA m 3 Ψ1915 23S rRNA m 5 C1962 1,3-propanediol acyl-CoA RNA tRNA Cm32 shikimate diamine N- diamine (S)-NADHX CaiT β-D-glucose -glutamyl-L-putrescine semialdehyde 3'-phosphomonoesterase: crotonobetainyl- mannokinase: α-ribazole-5'-P NADPHX putrescine acetyl-CoA dehydrogenase: fadJ dehydrogenase: fadE dehydrogenase: fadE dehydrogenase: 3'-nucleotidase: γ-butyrobetaine γ-butyrobetaine 6-phosphate aminoacetone xthA methyltransferase: methyltransferase: dehydrogenase: phosphohydrolase: methyltransferase: acetyltransferase: CoA mak transaminase: phosphatase: dehydratase: epimerase: aminotransferase: patA succinylglutamate DNA ligase: ligB predicted enoyl- γ-glutamylputrescine 1-acyl deoxyribodipyrimidine 3-hydroxyacyl-CoA predicted enoyl- rlmH rlmI yqhD rppH trmJ ydiB speG reductase: caiA umpG patA cobC nnr nnr a ribonucleoside NepI a ribonucleoside oxidase: tynA semialdehyde 3'-phosphomonoesterase: 3 lysophospholipase: pldB DNA ligase: ligA photolyase: phr dehydrogenase: fadB CoA reductase: ydiO an N - 1962 CoA reductase: ydiO a 2'-O- D-mannopyranose ω uridine oxidase: puuB nfo a 5-methylcytosine a 5'-phospho- an aliphatic N- crotonobetainyl- an aliphatic - 2-oxobutanoate dehydrogenase: methylpseudouridine 1915 3-hydroxypropionaldehyde methylcytidine 32 3-dehydroshikimate a ribonucleoside α-ribazole NADH (S)-NADPHX 1-dodecanol methylglyoxal 3-oxo-(5Z)-dodecenoyl-CoA (2E,7Z)-tetradecenoyl-CoA a [DNA]-3'- in 23S rRNA butanoyl-CoA [mRNA] acetyl-diamine CoA 6-phosphate aminoaldehyde HemY 4-(γ-glutamylamino)butanal astD hydroxyl in 23S rRNA in tRNA 2 two adjacent enterobactin EntS L-cysteine acetohydroxybutanoate N - a carboxylate L-1-glycerophosphorylethanolamine AMP (deoxynucleotides) NMN ethanolamine a phosphatidylglycerol enterobactin γ-glutamyl-γ- (m) thymidines in DNA degradation II synthase: ilvB ilvN succinylglutamate aminobutyraldehyde [+ 2 isozymes] dehydrogenase: puuC propanoyl-CoA succinylglutamate K + K + biotin BioP biotin 4-aminobutanal L-serine degradation α-D-Gal-(1->3)-α-L-Fuc- 4-methyl-5-(β- a uracil 1939 a supercoiled poly-[(R)-3- cytidine dCMP cys long chain 54 β glycerol 2- + + desuccinylase: astE a 1-lysophosphatidylethanolamine a phosphatidylethanolamine D-glucopyranose maltopentaose cis-vaccenoyl-CoA oleoyl-CoA cholate 34 met a uracil in tRNA an acyl phosphate aminoacetone L-quinate pantetheine an aldehyde -D-fructofuranose 8-oxo-GDP Na γ (S)-2-aceto-2- (1->4)-2/3-O-Ac-α-L-Fuc- hydroxyethyl)thiazole a cytidine in tRNA duplex DNA 2',3'-cyclic Na 4-(L- -glutamylamino)butanoate L-cysteine phosphate polyphosphate in 23S rRNA phosphate hydroxybutanoate] dCMP MdtM hydroxybutanoate (1->3)-α-D-Glc-PP-Und acyl-CoA acyl-CoA α 5 5 monophosphate a drug a drug γ desulfhydrase: galactosyl-(1->3)-L-fucosyl- 7- -hydroxysteroid 23S rRNA m U1939 Met tRNA(m U54) D-aminopropanol quinate aldehyde helicase: 8-oxo-GDP glycerol-2- kinase: -aminobutyraldehyde propionyltransferase: pta dehydrogenase: fadE dehydrogenase: fadE hydroxyethylthiazole tRNA cytidine pantetheine fructokinase: [+ 2 more] [+ 2 more] taurine ABC ser (R)-2,3-dihydroxy-3- glt succinate (1->4)-O-acetyl-L-fucosyl- dehydrogenase: methyltransferase: methyltransferase: acylphosphatase: dehydrogenase: dehydrogenase: dehydrogenase: dnaB diphosphatase: phosphatase: cmk taurine taurine γ-glutamyl-γ- dehydrogenase: patD cysM amylomaltase: exopolyphosphatase: ppx kinase: thiM acetyltransferase: kinase: coaA mak transporter L-serine propanoyl methylpentanoate:NADP + 2-acyl (1->3)-β-D-glucopyranosyl- predicted enoyl- predicted enoyl- hdhA rlmD trmA yccX gldA ydiB paoA paoC paoB [+ 2 isozymes] mutT suhB aminobutyrate aminobutyraldehyde 2-aminoprop-[+ 5 isozymes] malQ tmcA a lyso-cardiolipindCDP a lyso-cardiolipin deaminase: phosphate lysophospholipase: pldB diphosphoundecaprenol CoA reductase: ydiO CoA reductase: ydiO 4-methyl-5-(2- α α 1939 54 oxidoreductase long chain 3 ,12 -dihydroxy-7- a 5-methyluracil an N 4 -acetylcytidine 34 a 5-methyluracil (R)-1- F6P a single poly-[(R)-3- hydrolase: puuD dehydrogenase: puuC 2-enoate phosphonooxyethyl) a carboxylate 3-dehydroquinate 4'-phosphopantetheine a carboxylate 8-oxo-GMP glycerol 3'-cmp a lysophosphatidylglycerol LplT a lysophosphatidylglycerol sdaB (isomerizing): ilvC α acetyltransferase:α wcaB (2E,11Z)-octadecenoyl-CoA (2E,9Z)-octadecenoyl-CoA oxo-5β-cholan-24-oate in 23S rRNA met in tRNA aminopropan-2-ol stranded DNA hydroxybutanoate] cyanate CynX cyanate propionate 2-O-Ac- -D-Gal-(1->3)- - polyphosphate in [elongator tRNA ] a 1-lysophosphatidylethanolamine a 1-lysophosphatidylethanolamine [+ 3 isozymes] thiazole 2-aminoprop- kinase: ackA (R)-2,3-dihydroxy- maltose maltotetraose L-Fuc-(1->4)-2/3-O-Ac-α-L- 4-aminobutanoate a carboxylate L-1-glycerophosphorylethanolamine a 2-lysophosphatidylethanolamine a fatty acid 2-enoate propionate 3-methylpentanoate Fuc-(1->3)-α-D-Glc-PP-Und 2,3-dihydroxy-3- propanoate PutP propanoate cytosine CodB cytosine 4-aminobutyrate 2-iminopropanoate kinase: tdcD aminotransferase: puuE methylvalerate α propanoate a 2-methylthiocytosine 32 a mature peptidoglycan -D-ribose 1- a [protein]-L- 5,10- an N-hydroxy- D-gluconate dTTP hydro-lyase: ilvD 2-oxoglutarate (n) (5Z)-dodecenoyl-CoA a nucleoside a primary alcohol an mRNA tellurite N-ethylmaleimide 2-oxoglutaramate isovaleryl-CoA L-carnitinyl-CoA a polypeptide oxaloacetate 8-oxo-GTP glycerol 1- isoguanine nigerose 4-aminobutyrate (meso-DAP containing) (acetamidomethylphosphonate) β-isoaspartate arylamine 1-(β-D 1-(β-D 2-iminopropanoate (S)-3-methyl-2- in tRNA methenyltetrahydrofolate triphosphate 6-phosphate dTTP phosphate transaminase: gabT 5-triphosphate α acyl-CoA alcohol a polypeptide TatABC a polypeptide ribofuranosyl) PnuC ribofuranosyl) -D-ribose-1-(2-N- 5,10- nucleoside triphosphate N-hydroxyarylamine tellurite isovaleryl-CoA crotonobetainyl- alanyl pyrophosphatase: oxaloacetate 8-oxo-GTP- glycerol-3- isoguanine nigerose oxopentanoate L-isoaspartate protein dehydrogenase: fadE dehydrogenase: adhP RNase I 6-phosphogluconate N-ethylmaleimide 2-oxoglutaramate nicotinamide nicotinamide succinate semialdehyde peptidoglycan lytic acetamidomethylphosphonate) methenyltetrahydrofolate pyrophosphohydrolase: O-acetyltransferase: methyltransferase: dehydrogenase: CoA aminopeptidase: yhdE decarboxylase: diphosphatase: phosphatase: deaminase: hydrolase: pyruvate isoleucine 2-methylthiocytosine carboxylmethyltransferase: pcm predicted enoyl- alcohol endoribonuclease: rna phosphatase: yieH reductase: nemA amidase: yafV glutamine exotransglycosylase: mltA -5-triphosphate hydrolase: glyA mazG nhoA tehB aidB hydratase: caiD pepN eda mutT hxpA codA ygjK glycine cleavage transaminase: dethiomethylase: alkB a protein L-β- CoA reductase: ydiO dehydrogenase: adhE [+ 2 isozymes] succinate semialdehyde α-D-ribose-1-(2-N-diphosphatase: phnM 5-formyl- a single- an N- 3-methylcrotonyl- crotonobetainyl- 2'-deoxycytidine 2'-deoxycytidine ilvE degradation I [+ 2 isozymes] a nucleoside 5'- methanetelluronate D-gluconate N-ethylsuccinimide 2-oxoglutarate a polypeptide dTMP pyruvate 8-oxo-GMP glycerol xanthine α-D-glucose histidine succinate semialdehyde dehydrogenase pyruvate isoaspartate (2E,5Z)-dodecenoyl-CoA an aldehyde 2'-deoxyadenosine 2'-deoxyadenosine a [glycine- acetamidomethylphosphonate) tetrahydrofolate monophosphate stranded RNA acetoxyarylamine CoA CoA his ABC his NupC dehydrogenase (NAD + ): sad α-methyl ester 32 5-phosphate transporter thymidine thymidine + cleavage complex ile gln a 2-thiocytosine a mature peptidoglycan GlcNAc-1,6-anhMurNAc- (NADP ): gabD formaldehyde succinate (n) [+ 6 more] [+ 6 more] succinate-semialdehyde alanine degradation I H protein] N 6 -[(R glycine glutaminase: in tRNA (meso-DAP containing) L-Ala-γ-D-Glu-DAP-D-Ala dehydrogenase )-lipoyl]-L-lysine decarboxylase: ybaS xanthine xanthine + thiamine UacT (NAD ): puuC H-Gcv-protein- gcvP glutaminase urate urate α-L-fucosyl-(1->3)- a [release factor]- DNA containing methyl-1,4- a 3-dehydro- aldehydo- uridine 2'3'-cyclic thiamin ABC thiamin ala (dihydrolipoyl) B: yneH a double (KDO) -lipid A a 1-palmitoyl-2-acyl-sn- a double 3'-cmp β xylan 2 aminomethylphosphonate β glutathione 2-hydroxy-dATP a 23S rRNA 5-hydroxy-CTP spermidine an arylamine a quinone putrescine acetoin a -lactam monophosphate transporter glutamate succinate alanine stranded DNA glycero-3-phosphocholine -D-glucopyranosyl- stranded DNA L-glutamine a recognition site benzoquinone D-glucoside D-mannose lysine:NAD+ histidine degradation IV cytidine 3'-phosphate dependent racemase: dadX xanthosine-5'- diphosphoundecaprenol S-adenosyl-L- oxidized nucleoside protein-(glutamine-N 5 5-hydroxy-CTP type IV spermidine N 1 - arylamine N- NAD(P)H:quinone FMN dependent putrescine D-glucoside 3- predicted acetoin penicillinase: xylan α- mannose FMN FMN oxidoreductase: lpd α-L-fucosyl-(1->3)- YeeO acid resistance a [glycine- phosphate:L- aminomethylphosphonate exodeoxyribonuclease triphosphate RNase I phosphohydrolase: dehydrogenase: xylosidase: isomerase: FAD FAD D-serine [+ 3 isozymes] β-D-glucopyranosyl- methionine:glutathione ) methyltransferase: diphosphohydrolase: deoxyribonuclease: acetyltransferase: acetyltransferase: oxidoreductase: NADH:quinone aminotransferase: dehydrogenase: dacA ammonium AmtB ammonium a [glycine-cleavage glutamine N-acetyltransferase: phnO V: recC recB recD pyrophosphohydrolase: endoribonuclease: rna umpG ycjS yicI yihS D-alanine cleavage complex 6 methyltransferase: cheR prmC nudG mcrC mcrB speG nhoA qorB reductase,: azoR patA yohF [+ 2 isozymes] glt degradation complex H protein] N - his diphosphoundecaprenol 6 amido- nudG 5 cytidine 1 H protein] N - histidine-2- a [release factor]-N a single- N - an N- methyl-1,4- a D-glucoside a substituted α-D-xylopyranose keto-D-fructose 3'-UMP glutamate aminomethyldihydrolipoyl- 2-N-acetamidomethylphosphonate α O-acetyltransferase: wcaF a 5'-phosphooligonucleotide S-methylglutathione 5-hydroxy-CMP cleaved DNA a semiquinone 1-pyrroline diacetyl (R)- (R)- D-alanine:quinone dihydrolipoyl- ligase (AMP- 2/3-O-Ac- -L-Fuc- 2-hydroxy-dAMP -methyl-L-glutamine stranded RNA acetylspermidine acetylarylamine benzoquinol β-amino acid PanF D-serine L-lysine oxoglutarate pantothenate pantothenate decarboxylase oxidoreductase L-lysine forming): guaA hepta-acylated Kdo (1->3)-α-D-Glc-PP-Und asn AnsP asn aminotransferase 2 B: gadB (deaminating): dadA imidazole-pyruvate [+ 4 isozymes] a 5' phosphodinucleotide a 5'-phosphooligonucleotide a 1-lysophosphatidylcholine lipid A (E. coli) glutamate glt 4-hydroxybenzoate AaeAB 4-hydroxybenzoate decarboxylase D-serine pyruvate aminomethyltransferase: imidazol-pyruvate L-glutamine A: gadA ammonia- gcvT tryptophan reductase a 5-carboxymethylaminomethyluridine 34 [(R)-1- 3-phospho- 3-(3,4-dihydroxyphenyl) a cytosine 967 dCMP (3R)-3,4- UMP 2'-deoxycytidine cytidine 4-aminobutanoate lyase: dsdA lipid A-core 3-hydroxypropionaldehyde benzene-1,4-diol uroporphyrinogen-III rRNA 2-phosphoglycolate spermidine 5,6-dihydrouracil glycolaldehyde acetaldehyde an aldose α-lactose oxalyl-CoA gln ABC gln degradation II asparagine a phosphatidylethanolamine Leu 3'-monophosphate 2-dehydro- 2-dehydro- in tRNA aminoethyl]phosphonate hydroxypyruvate pyruvate in 16S rRNA dCMP dihydroxybutanal UMP transporter (via pyruvate) imidazole-lactate degradation I 5 8 aldehyde cytidine 3-deoxy-D- KdgT 3-deoxy-D- tRNA (5- (R)-1- hydroquinone:hydrogen uroporphyrinogen-III 16S rRNA m C967 phosphohydrolase: spermidine N - dihydropyrimidine D-3,4- acetaldehyde β oxalyl-CoA phosphatase: ammonium pyruvate 3-hydroxypropionaldehyde 3-phosphohydroxypyruvate hydroxyphenyllactate RNase I phosphoglycolate glycolaldehyde -galactosidase: kinase: udk glutamine carboxymethylaminomethyluridine) aminoethylphosphonate peroxide C-methyltransferase: methyltransferase: yfbR acetyltransferase: dehydrogenase: dihydroxybutanal dehydrogenase: dehydrogenase: decarboxylase: gluconate gluconate trp phosphoethanolamine dehydrogenase: puuC phosphatase: nudL endoribonuclease: rna phosphatase: gph reductase: yqhD lacZ umpH asn -ribose methyltransferase: trmL N-acetyltransferase: phnO dehydrogenase: hcxB oxidoreductase: ccp cysG rsmB speG preA preT reductase: yqhD aldB paoA paoC paoB oxc indole Mtr indole degradation II transferase: eptA 2'-deoxycytidine [+ 2 isozymes] CMP lysine degradation I L-asparaginase: a 5-carboxymethylaminomethyl- [(1R)-1- (R)-3-(3,4- a single- a 5-methylcytosine 967 N 8 - uracil an aldonate 2'-deoxycytidine 3-hydroxypropanoate hydroxypyruvate 1,4-benzoquinone precorrin-2 glycolate 1,3,4-butanetriol ethylene glycol acetate allolactose formyl-CoA uridine maltotetraose maltose ABC maltotetraose ansA 34 Leu gln tryptophanase: 2'-O-methyluridine in tRNA acetamidoethyl]phosphonate dihydroxyphenyl)lactate stranded RNA in 16S rRNA acetylspermidine maltotriose transporter maltotriose lipid A-core-1- N-acetyl-β- N-acetyl-β- L-glutamate:NADP+ tnaA L-asparaginase a 1,2-diacyl- NanC lys neuraminate neuraminate oxidoreductase II: ansB pyrophosphoethanolamine sn-glycerol asp succinate succinate lysine decarboxylase: ldcC (transaminating) indole pyruvate lysine decarboxylase: cadA : gltD gltB CitT α α 5,6- 5-fluorouridine 5'- 2'-deoxyuridine 3'- 2+ 2+ cadaverine UDP-α-D-galactose -L-Fuc-(1->4)-2/3-O-Ac- -L- a 5-(methoxycarbonylmethoxy) [(S)-1- a single a 5-(carboxymethoxy) a [ribosomal protein β-D-glucose CTP dUMP β CDP CMP uridine Zn Zn glt 11-deoxycorticosterone an mRNA coproporphyrinogen III a -D-galactoside dihydrothymine maltose monophosphate L-rhamnonate a D-guloside D-ribulose monophosphate citrate citrate Fuc-(1->3)-α-D-Glc-PP-Und 34 aminoethyl]phosphonate 34 L3]-L-glutamine 1-phosphate 2+ Mn 2+ 5-aminopentanoate 5-aminopentanoate uridine in tRNA stranded DNA uridine in tRNA nucleoside triphosphate dUMP putative UMP Mn ZupT GabP 5 galactoside O- dihydropyrimidine maltose O- 5-fluorouridine D-guloside 3- uridine 2+ 2+ 4-aminobutanoate 4-aminobutanoate tRNA (5- (S)-1- single stranded tRNA cmo U34 protein-glutamine N- RNA β pyrophosphohydrolase: phosphohydrolase: L-rhamnonate nucleoside (IDP) D-ribulokinase: phosphatase: Co Co galactosyltransferase: 11-deoxycorticosterone -phosphoglucomutase: porphyrinogen acetyltransferase: dehydrogenase: acetyltransferase: 5'-nucleotidase: dehydrogenase: kinase: udk methoxycarbonylmethoxyuridine) aminoethylphosphonate endodeoxyribonuclease: methyltransferase: methyltransferase: pyrophosphohydrolase: mazG yfbR dehydratase: diphosphatase: fucK umpH [+ 2 more] [+ 2 more] wcaC reductase: kduD ycjU peroxidase: yfeX lacA preA preT yjjG -ribose methyltransferase: trmL N-acetyltransferase: phnO recC recB recD cmoM prmB rppH maa rhmD ycjQ yibQ CMP 2'-deoxyuridine a 6-acetyl-β- thymine a 3-dehydro- [+ 2 isozymes] 2'-deoxyuridine UMP cadaverine CadB cadaverine a 5-(methoxycarbonylmethoxy) [(1S)-1- 4-pregnen- a 5-(methoxycarbonylmethoxy) a [ribosomal protein L3]- a 5'-phospho- β-D-glucose 2-dehydro-3-deoxy- D-ribulose thiosulfate thiosulfate a 5'-phosphooligonucleotide coproporphyrin III D-galactoside acetylmaltose 5-fluorouridine D-guloside CMP cytidine thiosulfate/ 34 20,21-diol-3-one 34 N 5 -methyl-L-glutamine 6-phosphate L-rhamnonate 1-phosphate sulfate α-D-Gal-(1->3)-α-L-Fuc-(1->4)-2/3-O UDP -2'-O-methyluridine in tRNA acetamidoethyl]phosphonate uridine in tRNA [mRNA] sulfate sulfate ABC α α selenite selenite -Ac- -L-Fuc-(1->3)- -D-Glc-PP-Und β-D-glucose 6-phosphate transporter D-selenomethionine ferric thiosulfate selenate selenate succinate L-glyceraldehyde 3-phosphate ferric D-methionine leu arg ferric enterobactin α-lactose 6'-phosphate sulfate YfgH cob(I)alamin lys phosphate F6P ferrichrome coprogen putrescine ferrichrome L-methionine S-oxide thiosulfate val L-ornithine sn-glycerol enterobactin complex sucrose 6-phosphate selenite ethidium deoxycholate molybdate thiosulfate cobinamide thymine D-glucosamine hydrophilic D-cycloserine (S)-malate met leu arg nalidixate α-lactose 6'-phosphate α-lactose 6'-phosphate α-lactose 6'-phosphate α-D-mannose 6-phosphate α-lactose 6'-phosphate ferric coprogen spermidine molybdate molybdate [+ 2 more] sulfate cobinamide glutathione cob(I)alamin hypoxanthine putrescine cadaverine 4-aminobutanoate ile putrescine agmatine hypoxanthine complex a sugar phosphate phosphate a dipeptide selenate nalidixate a drug tetraphenylphosphonium sulfate 6-phosphate asp asp asp asp leu 3-phosphate sn-glycerol adenine adenine carbonylcyanide m-chlorophenylhydrazone putrescine deoxycholate thiosulfate pro pro a quaternary ammonium compound pro guanine xanthine D-glucosamine D-galactarate D-galactarate maltose glycolate solute or β-D- β-alanine trp lys lys glt glt trp trp fumarate succinate val ser ser L-ornithine L-canavanine arg a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA guanine a C4- + sucrose 6-phosphate sucrose 6-phosphate sucrose 6-phosphate phosphate phosphate phosphate sucrose 6-phosphate a tripeptide a tripeptide a tripeptide spermidine choline val cys cys xanthine xanthine N-acetylneuraminate N-acetylneuraminate maltose putrescine putrescine putrescine pyruvate glt glt glt glt pyruvate (S)-lactate (S)-lactate an acid an acid K a dipeptide L-arabinose a nucleoside 2-nitroimidazole glycine betaine norfloxacin pro uracil + acetate ala D-serine carbonylcyanide m-chlorophenylhydrazone asp val arg 3-phosphate + cis-vaccenoyl-CoA cis-vaccenoyl-CoA dicarboxylate deoxycholate phosphate a dipeptide a dipeptide L-arabinose O-acetyl-L-serine O-acetyl-L-serine sulfate uracil AI-2 AI-2 AI-2 K 6-phosphate D-glucarate D-glucarate formate formate ion < 600 Da galactose ala asp ile K a sugar phosphate a sugar phosphate a sugar phosphate a sugar phosphate a sugar a dipeptide a drug ferric choline a drug a drug ile ferric ferrichrome cobalamin lysine / lysine / iron(III) coprogen spermidine sulfate/ L-methionine/ sulfate/ branched chain ferric enterobactin N-acetyl- sulfate/ ArcB sensory multidrug/ putrescine outer thiosulfate/ molybdate tripartite thiosulfate/ outer vitamin glutathione vitamin mannose- putrescine arginine / arginine / L-arginine sn-glycerol 3-phosphate multidrug phosphate dipeptide hydroxamate outer preferential thiosulfate L-valine D-methionine thiosulfate maltose ABC amino acid / enterobactin outer galactosamine thiosulfate histidine kinase NimT spermidine ABC YdeA EmrE BetT membrane MdtK sulfate ABC ABC efflux pump EamA EamB sulfate ABC membrane B ABC ABC CysW B ABC PutP ProP PPIII ProY GhxQ XanP XanQ UraA RutG NanC NanT specific PTS YdeZ YneA TqsA MdfA NagE GudP GarP LamB FocA FocB ActP OmpN MglBAC ABC PuuP PlaP PotE AlaE CycA DsdX TnaB LysP CadB ornithine EmrD BtsT GltI GltP GltK GltJ GltS GadC 03566 AroP Mtr DcuA DauA YjeH BrnQ SstT SdaC PotE ornithine ArgO ABC AdiC / glycerophosphodiester GlpT AdeQ ChaA FadK FadD AdeP GhxP LldP GlcA 02827 02828 DcuB efflux pump Kch EIIAga AgaD AgaV PitA PitB UhpT YjbB ABC AgaB YcjV ABC DtpD DtpA DtpC DtpB AraE NupG YdhI ABC membrane ABC ABC exporter ABC ABC 12 12 transporter phenylalanine ABC membrane transporter ABC - asp576 efflux pump exporter transport transporter transporter EmrKY-TolC transporter transport transporter transporter transporter enzyme II transporter ABC ABC transporter ABC transporter EmrAB-TolC transporter transporter transporter transport transporter transporter transporter transporter ABC transporter transporter transport complex transporter phosphorylated complex complex transporter transporter complex thymine hydrophilic D-cycloserine leu complex α-lactose α-lactose α-lactose α-lactose a quaternary ammonium compound uracil D-glucosamine succinate L-canavanine a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a C4- L-arabinose ethidium choline deoxycholate hypoxanthine xanthine xanthine N-acetylneuraminate putrescine putrescine putrescine β pyruvate asp (S)-malate met hypoxanthine a nucleoside 2-nitroimidazole L-arabinose pro xanthine solute or -alanine lys carbonylcyanide m-chlorophenylhydrazone glt asp val ser ser arg sn-glycerol cis-vaccenate cis-vaccenate dicarboxylate sucrose sucrose sucrose sucrose D-selenomethionine D-glucosamine glt fumarate L-ornithine adenine adenine ferric α-lactose phosphate thiosulfate a drug ferrichrome nalidixate a drug tetraphenylphosphonium cobinamide guanine uracil ion < 600 Da ala D-serine a drug glt leu ile arg 3-phosphate guanine nalidixate a sugar a sugar a sugar phosphate a sugar putrescine deoxycholate cob(I)alamin enterobactin ferric sucrose sulfate ferric coprogen ferric spermidine glycine betaine ferrichrome norfloxacin D-methionine 4-aminobutanoate asp val putrescine agmatine carbonylcyanide m-chlorophenylhydrazone β-D-glucose 6-phosphate cobinamide lys complex coprogen choline a drug L-methionine S-oxide ile phosphate enterobactin deoxycholate a sugar L-glyceraldehyde 3-phosphate selenite [+ 2 more] β succinate complex F6P selenate putrescine thiosulfate thiosulfate thiosulfate D-galactarate D-galactarate glycolate -D- leu a tripeptide a tripeptide a tripeptide N-acetylneuraminate maltose maltose asp asp asp arbutin arg sn-glycerol + molybdate molybdate molybdate glutathione cob(I)alamin pro pro pro galactose putrescine trp trp trp val arg (S)-lactate (S)-lactate an acid an acid K phosphate phosphate α-D-mannose 6-phosphate a dipeptide a dipeptide spermidine cys cys sulfate sulfate sulfate + D-glucarate D-glucarate acetate 3-phosphate + a sugar a dipeptide a dipeptide a dipeptide val AI-2 AI-2 AI-2 K formate formate ala cadaverinelys glt glt glt L-ornithine K phosphate O-acetyl-L-serine O-acetyl-L-serine ile Copyright © 2011, SRI International. All rights reserved. This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.