Additional Table 1 Enriched pathways of upregulated DEGs by the phosphorylation deficient of CRMP2 (P <0.05, q <0.05) Database Description Ratio of DEGs Ratio of universe P -value P adjust q -value Gene name GO structural constituent of ribosome 77/880 170/11165 1.97E-40 1.30E-37 1.25E-37 Mrpl17/Gm10036/Rpl36- ps3/Gm10263/Mrpl11/Rps15a/Rps20/Mrpl51/Gm10073/Mrpl2/Mrpl52/Rpl22/M rpl54/Mrps34/Gm2000/Mrpl4/Mrps24/Mrpl36/Rpl28/Mrpl34/Mrpl55/Rpl29/Rpl 37rt/Rpl23a- ps3/Mrps18a/Mrpl12/Rpl23a/Rpl18/Rpl35a/Mrpl33/Mrpl41/Mrps12/Rps9/Rps1 8/Rps25/Rps5/Mrps18c/Rps27a/Rps26/Rplp2/Rpl14/Mrpl20/Rps3/Rps4x/Rps16 /Rpl37/Rpl37a/Rps8/Mrps21/Rpl36/Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rpl3 1/Rpl39/Rps13/Rps11/Rpl8/Fau/Rps21/Rps19/Rpl9/Rpl38/Rpl26/Rps15/Rpl13a/ Rpl41/Rpl24/Rpl19/Rps14/Ndufa7/Rps27/Rplp1/Rps29 GO ribosome 91/907 248/11442 2.51E-38 1.41E-35 1.29E-35 Malsu1/Mrpl17/Zfp622/Gm10036/Rpl36- ps3/Gm10263/Gm10269/Mrpl11/Mrps28/Gm9493/Rpl13- ps3/Rps15a/Mrpl58/Rps20/Mrpl51/Gm10073/Mrpl2/Mrpl52/Rpl22/Mrpl54/Mrp s34/Gm2000/Mrpl4/Mrps24/Mrpl36/Rpl28/Mrpl34/Mrpl55/Rpl29/Rpl37rt/Rpl23 a- ps3/Rack1/Mrps18a/Mrps33/Mrpl12/Rpl23a/Rpl18/Rpl35a/Aurkaip1/Mrpl33/Btf 3/Mrpl41/Mrps12/Rpl36a/Rps9/Rps18/Rps25/Rps5/Mrps18c/Rps27a/Rps26/Rpl p2/Rpl14/Mrpl20/Rps3/Ndufab1/Rps4x/Rps16/Rpl37/Rpl37a/Rps8/Mrps21/Rpl 36/Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rpl31/Rpl39/Rps13/Rps11/Rpl8/Fau/ Rps21/Rps19/Rpl9/Rpl38/Rpl26/Rps15/Rpl13a/Uba52/Rpl41/Rpl24/Rpl19/Rps1 4/Ndufa7/Rps27/Rplp1/Rps29 GO ribosomal subunit 84/907 215/11442 8.01E-38 2.26E-35 2.07E-35 Malsu1/Mrpl17/Zfp622/Gm10036/Rpl36- ps3/Gm10263/Gm10269/Mrpl11/Mrps28/Gm9493/Rpl13- ps3/Rps15a/Mrpl58/Rps20/Mrpl51/Gm10073/Mrpl2/Mrpl52/Rpl22/Mrpl54/Mrp s34/Mrpl4/Mrps24/Mrpl36/Rpl28/Mrpl34/Mrpl55/Rpl29/Rpl23a- ps3/Rack1/Mrps18a/Mrpl12/Rpl23a/Rpl18/Rpl35a/Mrpl33/Mrpl41/Mrps12/Rpl3 6a/Rps9/Rps18/Rps25/Rps5/Mrps18c/Rps27a/Rps26/Rplp2/Rpl14/Mrpl20/Rps3 /Ndufab1/Rps4x/Rps16/Rpl37/Rpl37a/Rps8/Mrps21/Rpl36/Rpl11/Rps7/Rps17/R pl35/Rpl27/Rps28/Rpl31/Rpl39/Rps13/Rps11/Rpl8/Fau/Rps21/Rps19/Rpl9/Rpl3 8/Rpl26/Rps15/Rpl13a/Uba52/Rpl24/Rpl19/Rps14/Rps27/Rplp1/Rps29 KEGG Ribosome 63/374 118/4117 3.60E-36 8.88E-34 8.82E-34 Mrpl17/Mrpl11/Rps15a/Rps20/Rpl34/Rpl34- ps1/Gm4705/Mrpl2/Rpl22/Rps27/Rps27rt/Mrpl4/Mrpl36/Rpl28/Mrpl34/Rpl29/ Gm8210/Rpl37/Rpl37rt/Mrps18a/Mrpl12/Rpl23a/Rpl18/Rpl35a/Mrpl33/Mrps12/ Rpl36a/Rpl36al/Rps9/Rps18/Rps25/Rps5/Mrps18c/Rps27a/Rps26/Rplp2/Rpl14/ Mrpl20/Rps3/Rps4x/Rps16/Rpl37a/Rps8/Mrps21/Rpl36/Rpl11/Rps7/Rps17/Rpl3 5/Rpl27/LOC108167922/Rps28/Rpl31/Rpl39/Rps13/Rps11/Rpl8/Fau/Rps21/Rps 19/Rpl9/Rpl38/Rpl26/Rpl13a/Uba52/Rpl41/Rpl24/Rps14/Rplp1/Rps29 Reactome SRP-dependent cotranslational 52/460 84/5641 2.25E-36 1.49E-33 1.30E-33 Rps15a/Rps20/Rpl34- protein targeting to membrane ps1/Rpl22/Rps27rt/Rpl28/Rpl29/Rpl37rt/Rpl23a/Rpl18/Rpl35a/Rpl36a/Rps9/Rps 18/Rps25/Rps5/Rps27a/Rps26/Rplp2/Rpl14/Rps3/Rps4x/Rps16/Rpl37/Rps8/Rpl 36al/Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rpl31/Rpl39/Rps13/Rps11/Rpl8/Sr p14/Rps21/Rps19/Rpl9/Rpl38/Rpl26/Rps15/Rpl13a/Uba52/Rpl24/Rpl19/Rps14/ Rps27/Rplp1/Rps29 Reactome Nonsense Mediated Decay (NMD) 52/460 85/5641 5.38E-36 1.78E-33 1.55E-33 Rps15a/Pabpc1/Rps20/Rpl34- independent of the Exon Junction ps1/Rpl22/Rps27rt/Rpl28/Rpl29/Rpl37rt/Rpl23a/Rpl18/Rpl35a/Rpl36a/Rps9/Rps Complex (EJC) 18/Rps25/Rps5/Rps27a/Rps26/Rplp2/Rpl14/Rps3/Rps4x/Rps16/Rpl37/Rps8/Rpl 36al/Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rpl31/Rpl39/Rps13/Rps11/Rpl8/Rp s21/Rps19/Rpl9/Rpl38/Rpl26/Rps15/Rpl13a/Uba52/Rpl24/Rpl19/Rps14/Rps27/ Rplp1/Rps29 GO mitochondrial protein complex 86/907 241/11442 3.63E-35 6.82E-33 6.23E-33 Malsu1/Mrpl17/Mrpl11/Mrps28/Mrpl58/Mtx2/Mrpl51/Sdhc/Mtx1/Timm10b/Mr pl2/Mrpl52/Mrpl54/Mrps34/Mrpl4/Bax/Etfb/Mrps24/Mrpl36/Dnajc19/Dmac1/T omm6/Mrpl34/Mrpl55/Uqcc3/Ndufa11/Pam16/Mrps18a/Mrpl12/Mrpl33/Timm 13/Timm10/Pink1/Tomm7/Mrpl41/Mrps12/Gm10250/Ndufb2/Mrps18c/Ndufa6 /Ndufb4/Mrpl20/Chchd6/Ndufab1/Ndufb11/Ndufb7/Ndufc1/Mrps21/Romo1/T omm5/Ndufs7/Ndufs6/Smdt1/Ndufa5/Ndufv3/Ndufb3/Ndufa8/Ndufb5/Park7/ Ndufa13/Atp5j2/Atp5l/Ndufb10/Uqcrq/Atp5e/Ndufa3/Ndufa7/Atp5k/Cox5a/At p5d/Ndufa2/Ndufa1/Atp5g3/Atp5o/Ndufb8/Ndufs5/Ndufa4/Ndufc2/Atp5h/Ch chd10/Uqcr10/Uqcrh/Ndufb6/Ndufb9/Cox4i1/Cox6a1 Reactome Translation 80/460 216/5641 2.47E-34 5.45E-32 4.73E-32 Mrpl17/Mrpl11/Trmt112/Mrps28/Eif2b2/Rps15a/Mrpl58/Pabpc1/Rps20/Mrpl51 /Rpl34- ps1/Mrpl2/Mrpl52/Rpl22/Mrpl54/Mrps34/Rps27rt/Mrpl4/Mrps24/Mrpl36/Rpl28 /Eif3f/Mrpl34/Mrpl55/Rpl29/Rpl37rt/Mrps18a/Mrps33/Mrpl12/Rpl23a/Rpl18/Rp l35a/Aurkaip1/Mrpl33/Mrpl41/Mrps12/Rpl36a/Rps9/Rps18/Rps25/Rps5/Mrps18 c/Rps27a/Rps26/Rplp2/Rpl14/Mrpl20/Rps3/Rps4x/Rps16/Rpl37/Rps8/Rpl36al/ Mrps21/Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rpl31/Rpl39/Rps13/Rps11/Rpl8 /Srp14/Rps21/Rps19/Rpl9/Rpl38/Rpl26/Rps15/Rpl13a/Uba52/Rpl24/Rpl19/Rps1 4/Rps27/Rplp1/Rps29 Reactome Formation of a pool of free 40S 52/460 93/5641 3.15E-33 5.23E-31 4.54E-31 Rps15a/Rps20/Rpl34- subunits ps1/Rpl22/Rps27rt/Rpl28/Eif3f/Rpl29/Rpl37rt/Rpl23a/Rpl18/Rpl35a/Rpl36a/Rps 9/Rps18/Rps25/Rps5/Rps27a/Rps26/Rplp2/Rpl14/Rps3/Rps4x/Rps16/Rpl37/Rps 8/Rpl36al/Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rpl31/Rpl39/Rps13/Rps11/Rpl 8/Rps21/Rps19/Rpl9/Rpl38/Rpl26/Rps15/Rpl13a/Uba52/Rpl24/Rpl19/Rps14/Rp s27/Rplp1/Rps29 GO cytosolic ribosome 60/907 132/11442 1.28E-31 1.80E-29 1.65E-29 Zfp622/Gm10036/Rpl36-ps3/Gm10263/Gm10269/Gm9493/Rpl13- ps3/Rps15a/Rps20/Gm10073/Rpl22/Rpl28/Rpl29/Rpl23a- ps3/Rack1/Rpl23a/Rpl18/Rpl35a/Rpl36a/Rps9/Rps18/Rps25/Rps5/Rps27a/Rps2 6/Rplp2/Rpl14/Rps3/Rps4x/Rps16/Rpl37/Rpl37a/Rps8/Rpl36/Rpl11/Rps7/Rps17 /Rpl35/Rpl27/Rps28/Rpl31/Rpl39/Rps13/Rps11/Rpl8/Fau/Rps21/Rps19/Rpl9/Rp l38/Rpl26/Rps15/Rpl13a/Uba52/Rpl24/Rpl19/Rps14/Rps27/Rplp1/Rps29 Reactome L13a-mediated translational 53/460 103/5641 2.10E-31 2.79E-29 2.42E-29 Rps15a/Pabpc1/Rps20/Rpl34- silencing of Ceruloplasmin ps1/Rpl22/Rps27rt/Rpl28/Eif3f/Rpl29/Rpl37rt/Rpl23a/Rpl18/Rpl35a/Rpl36a/Rps expression 9/Rps18/Rps25/Rps5/Rps27a/Rps26/Rplp2/Rpl14/Rps3/Rps4x/Rps16/Rpl37/Rps 8/Rpl36al/Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rpl31/Rpl39/Rps13/Rps11/Rpl 8/Rps21/Rps19/Rpl9/Rpl38/Rpl26/Rps15/Rpl13a/Uba52/Rpl24/Rpl19/Rps14/Rp s27/Rplp1/Rps29 Reactome Nonsense-Mediated Decay 53/460 104/5641 3.97E-31 3.76E-29 3.27E-29 Rps15a/Pabpc1/Rps20/Rpl34- (NMD) ps1/Eif4a3/Rpl22/Rps27rt/Rpl28/Rpl29/Rpl37rt/Rpl23a/Rpl18/Rpl35a/Rpl36a/Rp s9/Rps18/Rps25/Rps5/Rps27a/Rps26/Rplp2/Rpl14/Rps3/Rps4x/Rps16/Rpl37/Rp s8/Rpl36al/Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rpl31/Rpl39/Rps13/Rps11/R pl8/Rps21/Rps19/Rpl9/Rpl38/Rpl26/Rps15/Rpl13a/Uba52/Rpl24/Rpl19/Rps14/R ps27/Rplp1/Rps29 Reactome Nonsense Mediated Decay (NMD) 53/460 104/5641 3.97E-31 3.76E-29 3.27E-29 Rps15a/Pabpc1/Rps20/Rpl34- enhanced by the Exon Junction ps1/Eif4a3/Rpl22/Rps27rt/Rpl28/Rpl29/Rpl37rt/Rpl23a/Rpl18/Rpl35a/Rpl36a/Rp Complex (EJC) s9/Rps18/Rps25/Rps5/Rps27a/Rps26/Rplp2/Rpl14/Rps3/Rps4x/Rps16/Rpl37/Rp s8/Rpl36al/Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rpl31/Rpl39/Rps13/Rps11/R pl8/Rps21/Rps19/Rpl9/Rpl38/Rpl26/Rps15/Rpl13a/Uba52/Rpl24/Rpl19/Rps14/R ps27/Rplp1/Rps29 GO inner mitochondrial membrane 54/907 108/11442 3.22E-31 3.63E-29 3.32E-29 Sdhc/Timm10b/Dnajc19/Dmac1/Uqcc3/Ndufa11/Pam16/Timm10/Gm10250/Nd protein complex ufb2/Ndufa6/Ndufb4/Chchd6/Ndufab1/Ndufb11/Ndufb7/Ndufc1/Romo1/Nduf s7/Ndufs6/Smdt1/Ndufa5/Ndufv3/Ndufb3/Ndufa8/Ndufb5/Park7/Ndufa13/Atp 5j2/Atp5l/Ndufb10/Uqcrq/Atp5e/Ndufa3/Ndufa7/Atp5k/Cox5a/Atp5d/Ndufa2/ Ndufa1/Atp5g3/Atp5o/Ndufb8/Ndufs5/Ndufa4/Ndufc2/Atp5h/Chchd10/Uqcr1 0/Uqcrh/Ndufb6/Ndufb9/Cox4i1/Cox6a1 Reactome Eukaryotic Translation Initiation 54/460 111/5641 2.26E-30 1.67E-28 1.45E-28 Eif2b2/Rps15a/Pabpc1/Rps20/Rpl34- ps1/Rpl22/Rps27rt/Rpl28/Eif3f/Rpl29/Rpl37rt/Rpl23a/Rpl18/Rpl35a/Rpl36a/Rps 9/Rps18/Rps25/Rps5/Rps27a/Rps26/Rplp2/Rpl14/Rps3/Rps4x/Rps16/Rpl37/Rps 8/Rpl36al/Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rpl31/Rpl39/Rps13/Rps11/Rpl 8/Rps21/Rps19/Rpl9/Rpl38/Rpl26/Rps15/Rpl13a/Uba52/Rpl24/Rpl19/Rps14/Rp s27/Rplp1/Rps29 Reactome Cap-dependent Translation 54/460 111/5641 2.26E-30 1.67E-28 1.45E-28 Eif2b2/Rps15a/Pabpc1/Rps20/Rpl34- Initiation ps1/Rpl22/Rps27rt/Rpl28/Eif3f/Rpl29/Rpl37rt/Rpl23a/Rpl18/Rpl35a/Rpl36a/Rps 9/Rps18/Rps25/Rps5/Rps27a/Rps26/Rplp2/Rpl14/Rps3/Rps4x/Rps16/Rpl37/Rps 8/Rpl36al/Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rpl31/Rpl39/Rps13/Rps11/Rpl 8/Rps21/Rps19/Rpl9/Rpl38/Rpl26/Rps15/Rpl13a/Uba52/Rpl24/Rpl19/Rps14/Rp s27/Rplp1/Rps29 Reactome GTP hydrolysis and joining of the 52/460 104/5641 5.11E-30 3.39E-28 2.94E-28 Rps15a/Rps20/Rpl34- 60S ribosomal subunit ps1/Rpl22/Rps27rt/Rpl28/Eif3f/Rpl29/Rpl37rt/Rpl23a/Rpl18/Rpl35a/Rpl36a/Rps 9/Rps18/Rps25/Rps5/Rps27a/Rps26/Rplp2/Rpl14/Rps3/Rps4x/Rps16/Rpl37/Rps 8/Rpl36al/Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rpl31/Rpl39/Rps13/Rps11/Rpl 8/Rps21/Rps19/Rpl9/Rpl38/Rpl26/Rps15/Rpl13a/Uba52/Rpl24/Rpl19/Rps14/Rp s27/Rplp1/Rps29 KEGG Oxidative phosphorylation 51/374 95/4117 1.98E-29 2.45E-27 2.43E-27 Sdhc/Ndufa11/Ndufb2/Atp6v1d/Ndufa6/Ndufb4/Ndufb4c/Ndufb4b/Ndufab1/ Ndufb11/Ndufb7/Ndufc1/Atp6v1g1/Cox17/Ndufs7/Ndufs6/Ndufv3/Ndufb3/N dufa8/Ndufb5/Ndufa13/Atp5j2/Atp5l/Ndufb10/Uqcrq/Atp6v1f/Atp5e/Cox7c/N dufa3/Ndufa7/Atp5k/Cox5a/Ndufa2/Ndufa1/Atp5g3/Uqcr11/Atp5o/Ndufs5/Nd ufa4/Ndufc2/Cox7b/Cox7a2/Atp6v0b/Atp5h/Uqcr10/Cox5b/Uqcrh/Ndufb6/Nd ufb9/Cox4i1/Cox6b1/Cox6a1/Cox8a GO respiratory chain 42/907 69/11442 3.32E-29 3.12E-27 2.86E-27 Sdhc/Dmac1/Uqcc3/Ndufa11/Ndufb2/Ndufa6/Ndufb4/Ndufab1/Ndufb11/Nduf b7/Ndufc1/Ndufs7/Ndufs6/Ndufa5/Ndufv3/Ndufb3/Ndufa8/Ndufb5/Park7/Nd ufa13/Ndufb10/Uqcrq/Ndufa3/Ndufa7/Cox5a/Ndufa2/Ndufa1/Uqcr11/Ndufb8 /Ndufs5/Ndufa4/Ndufc2/Cox7b/Cox7a2/Uqcr10/Uqcrh/Ndufb6/Ndufb9/Cox4i1 /Cox6b1/Cox6a1/Cox8a GO respiratory chain complex 40/907 63/11442 6.57E-29 5.29E-27 4.84E-27 Sdhc/Dmac1/Uqcc3/Ndufa11/Ndufb2/Ndufa6/Ndufb4/Ndufab1/Ndufb11/Nduf b7/Ndufc1/Ndufs7/Ndufs6/Ndufa5/Ndufv3/Ndufb3/Ndufa8/Ndufb5/Park7/Nd ufa13/Ndufb10/Uqcrq/Ndufa3/Ndufa7/Cox5a/Ndufa2/Ndufa1/Ndufb8/Ndufs5 /Ndufa4/Ndufc2/Cox7b/Uqcr10/Uqcrh/Ndufb6/Ndufb9/Cox4i1/Cox6b1/Cox6a 1/Cox8a GO mitochondrial membrane part 68/907 187/11442 1.61E-28 1.13E-26 1.04E-26 Mtx2/Sdhc/Mtx1/Pet100/Timm10b/Coq2/Dnajc19/Dmac1/Tomm6/Uqcc3/Nduf a11/Pam16/Timm10/Pink1/Tomm7/Gm10250/Ndufb2/Coa3/Ndufa6/Ndufb4/C hchd6/Ndufab1/Ndufb11/Ndufb7/Ndufc1/Romo1/Tomm5/Fis1/Ndufs7/Ndufs6 /Smdt1/Ndufa5/Ndufv3/Ndufb3/Mpc2/Ndufa8/Ndufb5/Park7/Ndufa13/Cisd1/ Atp5j2/Atp5l/Ndufb10/Uqcrq/Atp5e/Ndufa3/Ndufa7/Atp5k/Cox5a/Atp5d/Nduf a2/Ndufa1/Atp5g3/Atp5o/Ndufb8/Ndufs5/Ndufa4/Ndufc2/Cox7b/Cox7a2/Atp 5h/Chchd10/Uqcr10/Uqcrh/Ndufb6/Ndufb9/Cox4i1/Cox6a1 GO mitochondrial respiratory chain 39/907 64/11442 3.15E-27 1.98E-25 1.81E-25 Sdhc/Dmac1/Uqcc3/Ndufa11/Ndufb2/Ndufa6/Ndufb4/Ndufab1/Ndufb11/Nduf b7/Ndufc1/Ndufs7/Ndufs6/Ndufa5/Ndufv3/Ndufb3/Ndufa8/Ndufb5/Park7/Nd ufa13/Ndufb10/Uqcrq/Ndufa3/Ndufa7/Cox5a/Ndufa2/Ndufa1/Ndufb8/Ndufs5 /Ndufa4/Ndufc2/Cox7b/Cox7a2/Uqcr10/Uqcrh/Ndufb6/Ndufb9/Cox4i1/Cox6a Reactome Respiratory electron transport, 39/460 69/5641 2.45E-25 1.47E-23 1.28E-23 Timmdc1/Ndufaf7/Acad9/Etfb/Ndufaf2/Ndufaf3/Ndufb2/Ndufa6/Ndufb4/Nduf ATP synthesis by chemiosmotic ab1/Ndufb11/Ndufb7/Ndufc1/Ndufs7/Ndufs6/Ndufa5/Ndufv3/Ndufb3/Ndufa8 coupling, and heat production by /Ndufb5/Ndufa13/Atp5j2/Atp5l/Ndufb10/Atp5e/Ndufa3/Ndufa7/Atp5k/Atp5d/ uncoupling proteins. Ndufa2/Ndufa1/Atp5g3/Atp5o/Ndufb8/Ndufs5/Ndufc2/Atp5h/Ndufb6/Ndufb9 KEGG Parkinson disease 48/374 103/4117 3.83E-24 3.15E-22 3.13E-22 Gnai2/Sdhc/Ndufa11/Pink1/Ndufb2/Ndufa6/Ndufb4/Ndufb4c/Ndufb4b/Ndufa b1/Ndufb11/Ndufb7/Ndufc1/Ndufs7/Ndufs6/Ndufv3/Ndufb3/Ndufa8/Ndufb5/ Park7/Ndufa13/Ndufb10/Uqcrq/Atp5e/Cox7c/Ndufa3/Ndufa7/Cox5a/Ndufa2/ Ndufa1/Atp5g3/Uqcr11/Atp5o/Ndufs5/Uchl1/Ndufa4/Ndufc2/Cox7b/Cox7a2/A tp5h/Uqcr10/Cox5b/Uqcrh/Ndufb6/Ndufb9/Slc25a4/Cox4i1/Cox6b1/Cox6a1/C ox8a KEGG Huntington disease 55/374 138/4117 1.86E-23 1.15E-21 1.14E-21 Polr2a/Dlg4/Ift57/Polr2i/Polr2l/Sdhc/Bax/Polr2f/Polr2j/Ndufa11/Ndufb2/Ndufa 6/Ndufb4/Ndufb4c/Ndufb4b/Ndufab1/Ndufb11/Ndufb7/Ndufc1/Gpx1/Ap2s1/ Ndufs7/Ndufs6/Ndufv3/Ndufb3/Ndufa8/Ndufb5/Clta/Ndufa13/Ndufb10/Uqcrq /Atp5e/Cox7c/Ndufa3/Ndufa7/Cox5a/Ndufa2/Ndufa1/Atp5g3/Uqcr11/Atp5o/ Ndufs5/Ndufa4/Ndufc2/Cox7b/Cox7a2/Atp5h/Uqcr10/Cox5b/Uqcrh/Ndufb6/N dufb9/Slc25a4/Cox4i1/Cox6b1/Cox6a1/Cox8a Reactome Complex I biogenesis 30/460 46/5641 2.61E-22 1.44E-20 1.25E-20 Timmdc1/Ndufaf7/Acad9/Ndufaf2/Ndufaf3/Ndufb2/Ndufa6/Ndufb4/Ndufab1/ Ndufb11/Ndufb7/Ndufc1/Ndufs7/Ndufs6/Ndufa5/Ndufv3/Ndufb3/Ndufa8/Nd ufb5/Ndufa13/Ndufb10/Ndufa3/Ndufa7/Ndufa2/Ndufa1/Ndufb8/Ndufs5/Nduf c2/Ndufb6/Ndufb9 GO large ribosomal subunit 51/907 138/11442 5.09E-22 2.87E-20 2.62E-20 Malsu1/Mrpl17/Zfp622/Gm10036/Rpl36-ps3/Gm10269/Mrpl11/Rpl13- ps3/Mrpl58/Mrpl51/Gm10073/Mrpl2/Mrpl52/Rpl22/Mrpl54/Mrpl4/Mrpl36/Rpl2 8/Mrpl34/Mrpl55/Rpl29/Rpl23a- ps3/Mrps18a/Mrpl12/Rpl23a/Rpl18/Rpl35a/Mrpl33/Mrpl41/Rpl36a/Rplp2/Rpl1 4/Mrpl20/Ndufab1/Rpl37/Rpl37a/Rpl36/Rpl11/Rpl35/Rpl27/Rpl31/Rpl39/Rpl8/ Rpl9/Rpl38/Rpl26/Rpl13a/Uba52/Rpl24/Rpl19/Rplp1 GO mitochondrial inner membrane 86/907 354/11442 7.37E-22 3.78E-20 3.46E-20 Cpox/Slc25a28/Mrpl17/Slc25a16/Eci1/Slc25a33/Bdh1/Sdhc/Mtx1/Pet100/Timm 10b/Coq2/Dnajc19/Dmac1/Coq7/Ndufaf3/Uqcc3/Ndufa11/Pam16/Tmem126a/ Timm13/Timm10/Pink1/Gm10250/Ndufb2/Coa3/Ndufa6/Ndufb4/Chchd6/Rps3 /Ndufab1/Ndufb11/Ndufb7/Ndufc1/Mrps21/Romo1/Tmem256/Ndufs7/Ndufs6 /Smdt1/Ndufa5/Ndufv3/Uqcc2/Higd2a/Ndufb3/Mpc2/Ndufa8/Ndufb5/Park7/N dufa13/Atp5j2/Atp5l/Ndufb10/Uqcrq/Atp5e/Cox7c/Ndufa3/Ndufa7/Atp5k/Cox 5a/Atp5d/Ndufa2/Ndufa1/Atp5g3/Uqcr11/Atp5o/Ndufb8/Ndufs5/Ndufa4/Ndu fc2/Cox7b/Cox7a2/Atp5h/Timm8b/Chchd10/Uqcr10/Cox5b/Uqcrh/Ndufb6/Gp x4/Ndufb9/Slc25a4/Cox4i1/Cox6b1/Cox6a1/Cox8a Reactome Respiratory electron transport 31/460 51/5641 1.15E-21 5.86E-20 5.09E-20 Timmdc1/Ndufaf7/Acad9/Etfb/Ndufaf2/Ndufaf3/Ndufb2/Ndufa6/Ndufb4/Nduf ab1/Ndufb11/Ndufb7/Ndufc1/Ndufs7/Ndufs6/Ndufa5/Ndufv3/Ndufb3/Ndufa8 /Ndufb5/Ndufa13/Ndufb10/Ndufa3/Ndufa7/Ndufa2/Ndufa1/Ndufb8/Ndufs5/ Ndufc2/Ndufb6/Ndufb9 GO structural molecule activity 92/880 392/11165 2.10E-22 6.94E-20 6.63E-20 Cpox/Dlg3/Add3/Mrpl17/Gm10036/Rpl36- ps3/Krt12/Gm10263/Dlg4/Mrpl11/Tln1/Rps15a/Cldn10/Rps20/Add1/Mrpl51/N up88/Gm10073/Mrpl2/Mrpl52/Isca2/Rpl22/Mrpl54/Mrps34/Gm2000/Mrpl4/Mr ps24/Mrpl36/Rpl28/Mrpl34/Mrpl55/Rpl29/Rpl37rt/Rpl23a- ps3/Sptbn1/Mrps18a/Mrpl12/Rpl23a/Rpl18/Rpl35a/Mrpl33/Igfbp6/Mrpl41/Mrp s12/Rps9/Rps18/Rps25/Rps5/Mrps18c/Rps27a/Rps26/Rplp2/Rpl14/Mrpl20/Rps 3/Rps4x/Cryab/Rps16/Rpl37/Rpl37a/Rps8/Mrps21/Rpl36/Rpl11/Rps7/Rps17/Rp l35/Rpl27/Rps28/Rpl31/Rpl39/Rps13/Rps11/Rpl8/Clta/Fau/Rps21/Rps19/Rpl9/R pl38/Rpl26/Rps15/Rpl13a/Rpl41/Rpl24/Rpl19/Rps14/Ndufa7/Rps27/Myl6/Rplp1 /Rps29 GO mitochondrial respiratory chain 28/907 42/11442 1.82E-21 7.33E-20 6.70E-20 Dmac1/Ndufa11/Ndufb2/Ndufa6/Ndufb4/Ndufab1/Ndufb11/Ndufb7/Ndufc1/ complex I Ndufs7/Ndufs6/Ndufa5/Ndufv3/Ndufb3/Ndufa8/Ndufb5/Park7/Ndufa13/Nduf b10/Ndufa3/Ndufa7/Ndufa2/Ndufa1/Ndufb8/Ndufs5/Ndufc2/Ndufb6/Ndufb9 GO NADH dehydrogenase complex 28/907 42/11442 1.82E-21 7.33E-20 6.70E-20 Dmac1/Ndufa11/Ndufb2/Ndufa6/Ndufb4/Ndufab1/Ndufb11/Ndufb7/Ndufc1/ Ndufs7/Ndufs6/Ndufa5/Ndufv3/Ndufb3/Ndufa8/Ndufb5/Park7/Ndufa13/Nduf b10/Ndufa3/Ndufa7/Ndufa2/Ndufa1/Ndufb8/Ndufs5/Ndufc2/Ndufb6/Ndufb9 GO respiratory chain complex I 28/907 42/11442 1.82E-21 7.33E-20 6.70E-20 Dmac1/Ndufa11/Ndufb2/Ndufa6/Ndufb4/Ndufab1/Ndufb11/Ndufb7/Ndufc1/ Ndufs7/Ndufs6/Ndufa5/Ndufv3/Ndufb3/Ndufa8/Ndufb5/Park7/Ndufa13/Nduf b10/Ndufa3/Ndufa7/Ndufa2/Ndufa1/Ndufb8/Ndufs5/Ndufc2/Ndufb6/Ndufb9 Reactome Major pathway of rRNA 55/460 164/5641 3.22E-21 1.34E-19 1.16E-19 Riok3/Emg1/Rps15a/Rps20/Imp3/Rpl34- processing in the nucleolus and ps1/Rpp21/Rpl22/Rps27rt/Rpl28/Rpl29/Rpl37rt/Rpl23a/Rpl18/Rpl35a/Rpl36a/R cytosol ps9/Rps18/Rps25/Rps5/Rps27a/Rps26/Rplp2/Rpl14/Rps3/Rps4x/Rps16/Rpl37/R ps8/Rpl36al/Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rpl31/Rpl39/Rps13/Rps11/ Rpl8/Rps21/Rps19/Rpl9/Rpl38/Rpl26/Rps15/Rpl13a/Uba52/Rpl24/Rpl19/Rps14/ Rps27/Rplp1/Rps29 Reactome rRNA processing 55/460 164/5641 3.22E-21 1.34E-19 1.16E-19 Riok3/Emg1/Rps15a/Rps20/Imp3/Rpl34- ps1/Rpp21/Rpl22/Rps27rt/Rpl28/Rpl29/Rpl37rt/Rpl23a/Rpl18/Rpl35a/Rpl36a/R ps9/Rps18/Rps25/Rps5/Rps27a/Rps26/Rplp2/Rpl14/Rps3/Rps4x/Rps16/Rpl37/R ps8/Rpl36al/Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rpl31/Rpl39/Rps13/Rps11/ Rpl8/Rps21/Rps19/Rpl9/Rpl38/Rpl26/Rps15/Rpl13a/Uba52/Rpl24/Rpl19/Rps14/ Rps27/Rplp1/Rps29 Reactome rRNA processing in the nucleus 55/460 164/5641 3.22E-21 1.34E-19 1.16E-19 Riok3/Emg1/Rps15a/Rps20/Imp3/Rpl34- and cytosol ps1/Rpp21/Rpl22/Rps27rt/Rpl28/Rpl29/Rpl37rt/Rpl23a/Rpl18/Rpl35a/Rpl36a/R ps9/Rps18/Rps25/Rps5/Rps27a/Rps26/Rplp2/Rpl14/Rps3/Rps4x/Rps16/Rpl37/R ps8/Rpl36al/Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rpl31/Rpl39/Rps13/Rps11/ Rpl8/Rps21/Rps19/Rpl9/Rpl38/Rpl26/Rps15/Rpl13a/Uba52/Rpl24/Rpl19/Rps14/ Rps27/Rplp1/Rps29 GO mitochondrial membrane 103/907 490/11442 6.81E-21 2.56E-19 2.34E-19 Cpox/Slc25a28/Foxo3/Plekhn1/Mrpl17/Slc25a16/Eci1/Miga1/Acad9/Slc25a33/B dh1/Mtx2/Snn/Sdhc/Mtx1/Pet100/Timm10b/Coq2/Bax/Wasf1/Dnajc19/Dmac1/ Coq7/Tomm6/Ndufaf3/Uqcc3/Ndufa11/Pam16/Tmem126a/Timm13/Timm10/P ink1/Tomm7/Gm10250/Ndufb2/Coa3/Nme2/Ndufa6/Ndufb4/Chchd6/Rps3/Nd ufab1/Ndufb11/Ndufb7/Ndufc1/Nme1/Mrps21/Romo1/Tmem256/Tomm5/Fis1 /Ndufs7/Ndufs6/Smdt1/Ndufa5/Ndufv3/Uqcc2/Higd2a/Ndufb3/Mpc2/Ndufa8/ Ndufb5/Park7/Ndufa13/Cisd1/Atp5j2/Atp5l/Ndufb10/Uqcrq/Nrgn/Atp5e/Cox7 c/Ndufa3/Ndufa7/Atp5k/Cox5a/Atp5d/Ndufa2/Ndufa1/Atp5g3/Uqcr11/Atp5o/ Ndufb8/Ndufs5/Ndufa4/Ndufc2/Cox7b/Cox7a2/Atp5h/Timm8b/Chchd10/Uqcr 10/Cox5b/Uqcrh/Ndufb6/Gpx4/Ndufb9/Slc25a4/Cox4i1/Cox6b1/Cox6a1/Cfl1/C ox8a GO organelle inner membrane 88/907 382/11442 1.10E-20 3.86E-19 3.53E-19 Cpox/Slc25a28/Lemd2/Mrpl17/Slc25a16/Eci1/Slc25a33/Bdh1/Sdhc/Mtx1/Ifi27/ Pet100/Timm10b/Coq2/Dnajc19/Dmac1/Coq7/Ndufaf3/Uqcc3/Ndufa11/Pam16 /Tmem126a/Timm13/Timm10/Pink1/Gm10250/Ndufb2/Coa3/Ndufa6/Ndufb4/ Chchd6/Rps3/Ndufab1/Ndufb11/Ndufb7/Ndufc1/Mrps21/Romo1/Tmem256/N dufs7/Ndufs6/Smdt1/Ndufa5/Ndufv3/Uqcc2/Higd2a/Ndufb3/Mpc2/Ndufa8/Nd ufb5/Park7/Ndufa13/Atp5j2/Atp5l/Ndufb10/Uqcrq/Atp5e/Cox7c/Ndufa3/Nduf a7/Atp5k/Cox5a/Atp5d/Ndufa2/Ndufa1/Atp5g3/Uqcr11/Atp5o/Ndufb8/Ndufs5 /Ndufa4/Ndufc2/Cox7b/Cox7a2/Atp5h/Timm8b/Chchd10/Uqcr10/Cox5b/Uqcr h/Ndufb6/Gpx4/Ndufb9/Slc25a4/Cox4i1/Cox6b1/Cox6a1/Cox8a Hallmark OXIDATIVE_PHOSPHORYLATION 62/277 196/3054 9.50E-21 4.56E-19 4.30E-19 Eci1/Mrpl11/Mtx2/Sdhc/Bax/Etfb/Polr2f/Mrpl34/Cyb5a/Timm13/Timm10/Mrps 12/Ndufb2/Atp6v1d/Ndufa6/Ndufb4/Ndufab1/Ndufb7/Ndufc1/Atp6v1g1/Cox1 7/Ndufs7/Ndufs6/Ndufa5/Ndufb3/Ndufa8/Ndufb5/Atp5j2/Atp5l/Uqcrq/Atp6v1 f/Atp5e/Cox7c/Ndufa3/Ndufa7/Atp5k/Cox5a/Atp5d/Ndufa2/Ndufa1/Atp5g3/U qcr11/Atp5o/Ndufb8/Ndufa4/Ndufc2/Cox7b/Cox7a2/Atp6v0b/Atp5h/Timm8b/ Uqcr10/Cox5b/Uqcrh/Ndufb6/Gpx4/Mdh1/Slc25a4/Cox4i1/Cox6b1/Cox6a1/Co x8a GO cytosolic part 68/907 248/11442 1.54E-20 5.11E-19 4.67E-19 Fbxo45/Zfp622/Gm10036/Rpl36- ps3/Gm10263/Gm10269/Ubqln4/Gm9493/Rpl13- ps3/Rps15a/Rps20/Gm10073/Eif4a3/Rpl22/Rpl28/Rpl29/Bloc1s2/Rpl23a- ps3/Bloc1s1/Rack1/Sncb/Rpl23a/Rpl18/Rpl35a/Psmc4/Rpl36a/Rps9/Rps18/Rps 25/Rps5/Rps27a/Rps26/Rplp2/Rpl14/Rps3/Rps4x/Rps16/Rpl37/Rpl37a/Rps8/Rp l36/Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rpl31/Rpl39/Rps13/Rps11/Rpl8/Fau/ Rps21/Rps19/Rpl9/Rpl38/Rpl26/Rps15/Rpl13a/Uba52/Rpl24/Rpl19/Rps14/Prkc b/Rps27/Rplp1/Rps29 KEGG Alzheimer disease 46/374 121/4117 1.03E-18 5.10E-17 5.07E-17 Adam10/Cdk5r1/Sdhc/Psenen/Ndufa11/Ndufb2/Ndufa6/Ndufb4/Ndufb4c/Ndu fb4b/Ndufab1/Ndufb11/Ndufb7/Ndufc1/Ndufs7/Ndufs6/Ndufv3/Ndufb3/Nduf a8/Ndufb5/Ndufa13/Ndufb10/Uqcrq/Atp5e/Cox7c/Ndufa3/Ndufa7/Cox5a/Ndu fa2/Ndufa1/Atp5g3/Uqcr11/Atp5o/Ndufs5/Ndufa4/Ndufc2/Cox7b/Cox7a2/Atp 5h/Uqcr10/Cox5b/Uqcrh/Ndufb6/Ndufb9/Cox4i1/Cox6b1/Cox6a1/Cox8a GO mitochondrial respiratory chain 36/888 75/11253 1.67E-20 6.71E-17 6.71E-17 Ndufaf7/Acad9/Slc25a33/Pet100/Ndufaf8/Dmac1/Ndufaf3/Uqcc3/Ndufa11/Sd complex assembly haf4/Ndufb2/Coa3/Ndufa6/Ndufab1/Ndufb11/Ndufb7/Ndufc1/Cox17/Ndufs7/ Cox14/Ndufa5/Uqcc2/Ndufb3/Ndufa8/Ndufb5/Ndufa13/Ndufb10/Ndufa3/Ndu fa2/Ndufa1/Ndufb8/Ndufs5/Ndufc2/Uqcr10/Ndufb6/Ndufb9 GO cytosolic small ribosomal subunit 28/907 51/11442 3.38E-18 1.06E-16 9.68E-17 Gm10263/Gm9493/Rps15a/Rps20/Rack1/Rps9/Rps18/Rps25/Rps5/Rps27a/Rps 26/Rps3/Rps4x/Rps16/Rps8/Rps7/Rps17/Rps28/Rps13/Rps11/Fau/Rps21/Rps19 /Rps15/Uba52/Rps14/Rps27/Rps29 KEGG Thermogenesis 53/374 160/4117 2.60E-18 1.07E-16 1.06E-16 Smarcd1/Ndufaf7/Sdhc/Ndufaf2/Ndufaf3/Ndufa11/Ndufb2/Coa3/Ndufa6/Nduf b4/Ndufb4c/Ndufb4b/Ndufab1/Ndufb11/Ndufb7/Ndufc1/Cox17/Ndufs7/Nduf s6/Cox14/Ndufv3/Ndufb3/Ndufa8/Ndufb5/Ndufa13/Atp5j2/Atp5l/Ndufb10/Uq crq/Atp5e/Cox7c/Ndufa3/Ndufa7/Atp5k/Cox5a/Ndufa2/Ndufa1/Atp5g3/Uqcr1 1/Atp5o/Ndufs5/Ndufa4/Ndufc2/Cox7b/Cox7a2/Atp5h/Uqcr10/Cox5b/Uqcrh/ Ndufb6/Ndufb9/Cox4i1/Cox6b1/Cox6a1/Cox8a KEGG Non-alcoholic fatty liver disease 41/374 101/4117 5.49E-18 1.94E-16 1.92E-16 Gsk3a/Sdhc/Bax/Ndufa11/Ndufb2/Ndufa6/Ndufb4/Ndufb4c/Ndufb4b/Ndufab1 (NAFLD) /Ndufb11/Ndufb7/Ndufc1/Ndufs7/Ndufs6/Ndufv3/Ndufb3/Ndufa8/Ndufb5/Nd ufa13/Ndufb10/Uqcrq/Cox7c/Ndufa3/Ndufa7/Cox5a/Ndufa2/Ndufa1/Uqcr11/ Ndufs5/Ndufa4/Ndufc2/Cox7b/Cox7a2/Uqcr10/Cox5b/Uqcrh/Ndufb6/Ndufb9/ Cox4i1/Cox6b1/Cox6a1/Cox8a GO small ribosomal subunit 35/907 82/11442 7.51E-18 2.23E-16 2.04E-16 Gm10263/Mrps28/Gm9493/Rps15a/Rps20/Mrps34/Mrps24/Rack1/Mrps18a/Mr ps12/Rps9/Rps18/Rps25/Rps5/Mrps18c/Rps27a/Rps26/Rps3/Rps4x/Rps16/Rps8 /Mrps21/Rps7/Rps17/Rps28/Rps13/Rps11/Fau/Rps21/Rps19/Rps15/Uba52/Rps 14/Rps27/Rps29 GO NADH dehydrogenase complex 27/888 44/11253 2.15E-19 2.88E-16 2.88E-16 Ndufaf7/Acad9/Ndufaf8/Dmac1/Ndufaf3/Ndufa11/Ndufb2/Ndufa6/Ndufab1/N assembly dufb11/Ndufb7/Ndufc1/Ndufs7/Ndufa5/Ndufb3/Ndufa8/Ndufb5/Ndufa13/Nd ufb10/Ndufa3/Ndufa2/Ndufa1/Ndufb8/Ndufs5/Ndufc2/Ndufb6/Ndufb9 GO mitochondrial respiratory chain 27/888 44/11253 2.15E-19 2.88E-16 2.88E-16 Ndufaf7/Acad9/Ndufaf8/Dmac1/Ndufaf3/Ndufa11/Ndufb2/Ndufa6/Ndufab1/N complex I assembly dufb11/Ndufb7/Ndufc1/Ndufs7/Ndufa5/Ndufb3/Ndufa8/Ndufb5/Ndufa13/Nd ufb10/Ndufa3/Ndufa2/Ndufa1/Ndufb8/Ndufs5/Ndufc2/Ndufb6/Ndufb9 GO oxidoreductase complex 35/907 86/11442 4.69E-17 1.32E-15 1.21E-15 Ogdhl/Sdhc/Etfb/Dmac1/Uqcc3/Ndufa11/Ndufb2/Ndufa6/Ndufb4/Ndufab1/N dufb11/Ndufb7/Ndufc1/Ndufs7/Ndufs6/Ndufa5/Ndufv3/Ndufb3/Ndufa8/Nduf b5/Park7/Ndufa13/Ndufb10/Uqcrq/Ndufa3/Ndufa7/Ndufa2/Ndufa1/Ndufb8/N dufs5/Ndufc2/Uqcr10/Uqcrh/Ndufb6/Ndufb9 GO cytosolic large ribosomal subunit 33/907 77/11442 5.71E-17 1.53E-15 1.40E-15 Zfp622/Gm10036/Rpl36-ps3/Gm10269/Rpl13- ps3/Gm10073/Rpl22/Rpl28/Rpl29/Rpl23a- ps3/Rpl23a/Rpl18/Rpl35a/Rpl36a/Rplp2/Rpl14/Rpl37/Rpl37a/Rpl36/Rpl11/Rpl3 5/Rpl27/Rpl31/Rpl39/Rpl8/Rpl9/Rpl38/Rpl26/Rpl13a/Uba52/Rpl24/Rpl19/Rplp1 Reactome The citric acid (TCA) cycle and 40/460 113/5641 1.33E-16 5.20E-15 4.51E-15 Timmdc1/Ndufaf7/Acad9/Sdhc/Etfb/Ndufaf2/Ndufaf3/Ndufb2/Ndufa6/Ndufb4 respiratory electron transport /Ndufab1/Ndufb11/Ndufb7/Ndufc1/Ndufs7/Ndufs6/Ndufa5/Ndufv3/Ndufb3/N dufa8/Ndufb5/Ndufa13/Atp5j2/Atp5l/Ndufb10/Atp5e/Ndufa3/Ndufa7/Atp5k/A tp5d/Ndufa2/Ndufa1/Atp5g3/Atp5o/Ndufb8/Ndufs5/Ndufc2/Atp5h/Ndufb6/N dufb9 Reactome Metabolism of RNA 90/460 478/5641 3.00E-15 1.10E-13 9.58E-14 Polr2a/Mnat1/Nxt1/Hnrnpa0/Hnrnpl/Adarb1/Riok3/Snrnp40/Sf3b5/Wbp11/An p32a/Hnrnpm/Lsm5/Emg1/Rps15a/Polr2i/Pabpc1/Paip1/Rps20/Lsm6/Imp3/Pol r2l/Nup88/Snrpd2/U2af1/Rpl34- ps1/Snrnp27/Rpp21/Eif4a3/Rpl22/Rps27rt/Snrpg/Cwc15/Nxf1/Srsf5/Rpl28/Lsm 4/Polr2f/Srsf2/Gtf2h5/Lsm7/Gemin7/Rpl29/Pcbp1/Srsf11/Rpl37rt/Rpl23a/Rpl18/ Rpl35a/Zcrb1/Rpl36a/Rps9/Rps18/Rps25/Rps5/Rps27a/Rps26/Rplp2/Rpl14/Rps 3/Rps4x/Rps16/Rpl37/Rps8/Rpl36al/Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rpl 31/Rpl39/Rps13/Rps11/Rpl8/Rps21/Rps19/Rpl9/Rpl38/Rpl26/Rps15/Rpl13a/Ub a52/Rpl24/Rpl19/Rps14/Rps27/Rplp1/Rps29 Reactome Formation of the ternary complex, 25/460 50/5641 6.04E-15 2.11E-13 1.83E-13 Rps15a/Rps20/Rps27rt/Eif3f/Rps9/Rps18/Rps25/Rps5/Rps27a/Rps26/Rps3/Rps4 and subsequently, the 43S x/Rps16/Rps8/Rps7/Rps17/Rps28/Rps13/Rps11/Rps21/Rps19/Rps15/Rps14/Rps complex 27/Rps29 Reactome Translation initiation complex 26/460 57/5641 2.84E-14 9.42E-13 8.18E-13 Rps15a/Pabpc1/Rps20/Rps27rt/Eif3f/Rps9/Rps18/Rps25/Rps5/Rps27a/Rps26/R formation ps3/Rps4x/Rps16/Rps8/Rps7/Rps17/Rps28/Rps13/Rps11/Rps21/Rps19/Rps15/R ps14/Rps27/Rps29 Reactome Activation of the mRNA upon 26/460 58/5641 4.77E-14 1.51E-12 1.31E-12 Rps15a/Pabpc1/Rps20/Rps27rt/Eif3f/Rps9/Rps18/Rps25/Rps5/Rps27a/Rps26/R binding of the cap-binding ps3/Rps4x/Rps16/Rps8/Rps7/Rps17/Rps28/Rps13/Rps11/Rps21/Rps19/Rps15/R complex and eIFs, and ps14/Rps27/Rps29 subsequent binding to 43S Reactome Ribosomal scanning and start 25/460 57/5641 2.76E-13 8.31E-12 7.21E-12 Rps15a/Rps20/Rps27rt/Eif3f/Rps9/Rps18/Rps25/Rps5/Rps27a/Rps26/Rps3/Rps4 codon recognition x/Rps16/Rps8/Rps7/Rps17/Rps28/Rps13/Rps11/Rps21/Rps19/Rps15/Rps14/Rps 27/Rps29 GO mitochondrion organization 74/888 400/11253 2.26E-12 2.27E-09 2.27E-09 Fnip1/Gsk3a/Mrpl17/Miga1/Ndufaf7/Rb1cc1/Acad9/Slc25a33/Dnlz/Alkbh7/Apo pt1/Pet100/Wdr45/Ndufaf8/Bax/Fmc1/Dnajc19/Jtb/Dmac1/Pdcd5/Coq7/Dctn6 /Bloc1s2/Ndufaf3/Uqcc3/Ndufa11/Pam16/Sdhaf4/Timm13/Timm10/Pink1/Tom m7/Ndufb2/Coa3/Ndufa6/Chchd6/Ndufab1/Ndufb11/Gabarapl2/Ndufb7/Nduf c1/Cox17/Gpx1/Romo1/Tomm5/Fis1/Ndufs7/Ndufs6/Cox14/Ndufa5/Uqcc2/Hi gd2a/Ndufb3/Ndufa8/Ndufb5/Park7/Ndufa13/Ndufb10/Ndufa3/Atp5d/Ndufa2 /Ndufa1/Ndufb8/Map1lc3a/Ndufs5/Ndufc2/Cox7a2/Chchd10/Uqcr10/Ndufb6/ Ndufb9/Slc25a4/Chchd2/Atpif1 KEGG Retrograde endocannabinoid 32/374 105/4117 2.45E-10 7.57E-09 7.52E-09 Gnai2/Gng10/Ndufa11/Gnb2/Slc17a7/Ndufb2/Ndufa6/Ndufb4/Ndufb4c/Ndufb signaling 4b/Ndufab1/Ndufb11/Ndufb7/Ndufc1/Ndufs7/Ndufs6/Ndufv3/Gng13/Ndufb3/ Ndufa8/Ndufb5/Ndufa13/Ndufb10/Gng3/Ndufa3/Ndufa7/Prkcb/Ndufa2/Ndufa 1/Ndufs5/Ndufa4/Ndufc2/Ndufb6/Ndufb9 GO mitochondrial ATP synthesis 21/888 48/11253 1.57E-11 1.27E-08 1.27E-08 Sdhc/Coq7/Uqcc3/Pink1/Ndufs6/Ndufv3/Ndufa8/Park7/Uqcrq/Cox7c/Ndufa7/ coupled electron transport Cox5a/Ndufb8/Ndufc2/Uqcr10/Cox5b/Uqcrh/Ndufb6/Ndufb9/Cox4i1/Cox6a1 GO ATP synthesis coupled electron 21/888 49/11253 2.55E-11 1.71E-08 1.71E-08 Sdhc/Coq7/Uqcc3/Pink1/Ndufs6/Ndufv3/Ndufa8/Park7/Uqcrq/Cox7c/Ndufa7/ transport Cox5a/Ndufb8/Ndufc2/Uqcr10/Cox5b/Uqcrh/Ndufb6/Ndufb9/Cox4i1/Cox6a1 GO oxidative phosphorylation 26/888 75/11253 3.54E-11 2.04E-08 2.04E-08 Slc25a33/Sdhc/Coq7/Uqcc3/Pink1/Ndufs6/Ndufv3/Uqcc2/Ndufa8/Park7/Uqcrq /Cox7c/Ndufa7/Cox5a/Atp5o/Ndufb8/Ndufc2/Cox7a2/Chchd10/Uqcr10/Cox5b /Uqcrh/Ndufb6/Ndufb9/Cox4i1/Cox6a1 GO electron transport chain 24/888 69/11253 1.87E-10 9.38E-08 9.38E-08 Sdhc/Coq7/Ndufaf2/Uqcc3/Pink1/Ndufs6/Ndufa5/Ndufv3/Ndufb3/Ndufa8/Par k7/Uqcrq/Cox7c/Ndufa7/Cox5a/Ndufb8/Ndufc2/Uqcr10/Cox5b/Uqcrh/Ndufb6 /Ndufb9/Cox4i1/Cox6a1 GO polysome 22/907 69/11442 7.56E-09 1.94E-07 1.77E-07 Naa30/Rwdd1/Rpl29/Drg1/Rpl18/Btf3/Vbp1/Rps25/Rps26/Rps3/Rps4x/Naa38/ Rpl11/Rps28/Rpl31/Rpl39/Rpl8/Rps21/Rpl38/Rpl24/Rpl19/Rps29 GO respiratory electron transport 23/888 66/11253 4.28E-10 1.91E-07 1.91E-07 Sdhc/Coq7/Ndufaf2/Uqcc3/Pink1/Ndufs6/Ndufa5/Ndufv3/Ndufa8/Park7/Uqcrq chain /Cox7c/Ndufa7/Cox5a/Ndufb8/Ndufc2/Uqcr10/Cox5b/Uqcrh/Ndufb6/Ndufb9/ Cox4i1/Cox6a1 GO polysomal ribosome 14/907 30/11442 1.53E-08 3.75E-07 3.43E-07 Rpl29/Rpl18/Btf3/Rps26/Rpl11/Rps28/Rpl31/Rpl39/Rpl8/Rps21/Rpl38/Rpl24/Rp l19/Rps29 Reactome Mitochondrial translation 24/460 83/5641 2.02E-08 5.82E-07 5.06E-07 Mrpl17/Mrpl11/Mrps28/Mrpl58/Mrpl51/Mrpl2/Mrpl52/Mrpl54/Mrps34/Mrpl4/ elongation Mrps24/Mrpl36/Mrpl34/Mrpl55/Mrps18a/Mrps33/Mrpl12/Aurkaip1/Mrpl33/Mr pl41/Mrps12/Mrps18c/Mrpl20/Mrps21 GO organellar ribosome 25/907 92/11442 2.78E-08 6.28E-07 5.74E-07 Malsu1/Mrpl17/Mrpl11/Mrps28/Mrpl58/Mrpl51/Mrpl2/Mrpl52/Mrpl54/Mrps34/ Mrpl4/Mrps24/Mrpl36/Mrpl34/Mrpl55/Mrps18a/Mrpl12/Mrpl33/Mrpl41/Mrps1 2/Mrps18c/Mrpl20/Ndufab1/Mrps21/Ndufa7 GO mitochondrial ribosome 25/907 92/11442 2.78E-08 6.28E-07 5.74E-07 Malsu1/Mrpl17/Mrpl11/Mrps28/Mrpl58/Mrpl51/Mrpl2/Mrpl52/Mrpl54/Mrps34/ Mrpl4/Mrps24/Mrpl36/Mrpl34/Mrpl55/Mrps18a/Mrpl12/Mrpl33/Mrpl41/Mrps1 2/Mrps18c/Mrpl20/Ndufab1/Mrps21/Ndufa7 GO cytochrome complex 11/907 19/11442 3.06E-08 6.64E-07 6.07E-07 Uqcc3/Uqcrq/Cox5a/Ndufa4/Cox7b/Uqcr10/Uqcrh/Cox4i1/Cox6b1/Cox6a1/Co x8a GO ribosome biogenesis 51/888 265/11253 1.64E-09 6.58E-07 6.58E-07 Tfb1m/Fbll1/Nvl/Gar1/Malsu1/Zfp622/Gm10036/Riok3/Gm10263/Gm10269/Ng dn/Mrpl11/Wbp11/Trmt112/Gm9493/Ipo4/Emg1/Frg1/Lsm6/Imp3/Nup88/Ddx 17/Nhp2/Mrpl36/Gtf2h5/Rpl23a- ps3/Pin4/Rpl23a/Rpl35a/Nop10/Pop5/Rps25/Rps5/Rpl14/Mrpl20/Rps16/Rps8/ Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rps21/Rps19/Rpl38/Rpl26/Rps15/Rpl24/ Rps14/Rps27 GO electron transfer activity 19/880 51/11165 3.85E-09 8.23E-07 7.87E-07 Glrx5/Glrx2/Sdhc/Etfb/Ndufaf2/Uqcrq/Cox7c/Sh3bgrl3/Cox5a/Uqcr11/Ndufa4/ Cox7b/Cox7a2/Uqcr10/Cox5b/Uqcrh/Cox4i1/Cox6a1/Cox8a GO rRNA binding 22/880 68/11165 4.98E-09 8.23E-07 7.87E-07 Mrpl11/Emg1/Imp3/Rpl37rt/Mrps18a/Rpl23a/Rps9/Rps18/Rps5/Mrps18c/Mrpl2 0/Rps3/Rps4x/Rpl37/Rpl37a/Rpl11/Rps13/Rps11/Rpl8/Rpl9/Rpl19/Rps14 Reactome Mitochondrial translation 24/460 85/5641 3.38E-08 9.33E-07 8.10E-07 Mrpl17/Mrpl11/Mrps28/Mrpl58/Mrpl51/Mrpl2/Mrpl52/Mrpl54/Mrps34/Mrpl4/ termination Mrps24/Mrpl36/Mrpl34/Mrpl55/Mrps18a/Mrps33/Mrpl12/Aurkaip1/Mrpl33/Mr pl41/Mrps12/Mrps18c/Mrpl20/Mrps21 Reactome Mitochondrial translation 24/460 86/5641 4.33E-08 1.15E-06 9.98E-07 Mrpl17/Mrpl11/Mrps28/Mrpl58/Mrpl51/Mrpl2/Mrpl52/Mrpl54/Mrps34/Mrpl4/ Mrps24/Mrpl36/Mrpl34/Mrpl55/Mrps18a/Mrps33/Mrpl12/Aurkaip1/Mrpl33/Mr pl41/Mrps12/Mrps18c/Mrpl20/Mrps21 GO cytoplasmic translation 24/888 85/11253 2.13E-08 7.78E-06 7.78E-06 Rpl36- ps3/Gm10073/Rwdd1/Rpl29/Drg1/Rpl18/Rpl35a/Rps26/Rpl36/Rpl11/Rps28/Rpl 31/Rpl39/Tma7/Rpl8/Rps21/Rpl9/Rpl38/Rpl26/Rpl13a/Rpl24/Rpl19/Rplp1/Rps2 9 GO cellular respiration 31/888 132/11253 2.45E-08 8.19E-06 8.19E-06 Ogdhl/Sdhc/Bax/Coq7/Ndufaf2/Uqcc3/Bloc1s1/Sdhaf4/Pink1/Ndufs7/Ndufs6/ Ndufa5/Ndufv3/Ndufa8/Park7/Cisd1/Uqcrq/Cox7c/Ndufa7/Cox5a/Atp5d/Nduf b8/Ndufc2/Uqcr10/Cox5b/Uqcrh/Ndufb6/Mdh1/Ndufb9/Cox4i1/Cox6a1 GO proton transmembrane transport 20/888 62/11253 2.69E-08 8.32E-06 8.32E-06 Slc4a10/Chp1/Slc17a7/Gm10250/Atp6v1g1/Cox17/Ndufs7/Park7/Atp5l/Atp6v1f /Atp5e/Atp5k/Atp5d/Atp5g3/Atp5o/Atp6v0b/Atp5h/Chchd10/Cox5b/Slc25a4 GO organellar large ribosomal 18/907 60/11442 4.90E-07 9.87E-06 9.02E-06 Malsu1/Mrpl17/Mrpl11/Mrpl58/Mrpl51/Mrpl2/Mrpl52/Mrpl54/Mrpl4/Mrpl36/M subunit rpl34/Mrpl55/Mrps18a/Mrpl12/Mrpl33/Mrpl41/Mrpl20/Ndufab1 GO mitochondrial large ribosomal 18/907 60/11442 4.90E-07 9.87E-06 9.02E-06 Malsu1/Mrpl17/Mrpl11/Mrpl58/Mrpl51/Mrpl2/Mrpl52/Mrpl54/Mrpl4/Mrpl36/M subunit rpl34/Mrpl55/Mrps18a/Mrpl12/Mrpl33/Mrpl41/Mrpl20/Ndufab1 GO proton transmembrane 21/880 72/11165 8.56E-08 1.13E-05 1.08E-05 Gm10250/Atp6v1d/Atp6v1g1/Atp5l/Atp6v1f/Atp5e/Cox7c/Atp5k/Cox5a/Atp5d transporter activity /Atp5g3/Atp5o/Ndufa4/Cox7b/Cox7a2/Atp6v0b/Atp5h/Cox5b/Cox4i1/Cox6a1/ Cox8a GO purine ribonucleoside 41/888 209/11253 3.79E-08 1.09E-05 1.09E-05 Rhoq/Slc25a33/Gphn/Sdhc/Coq7/Uqcc3/Pink1/Gm10250/Nme2/Nme1/Guk1/ triphosphate metabolic process Ndufs6/Ndufv3/Uqcc2/Ndufa8/Park7/Atp5j2/Atp5l/Uqcrq/Atp5e/Cox7c/Ndufa 7/Atp5k/Cox5a/Atp5d/Atp5g3/Atp5o/Ndufb8/Ndufc2/Cox7a2/Mif/Atp5h/Chch d10/Uqcr10/Cox5b/Uqcrh/Ndufb6/Ndufb9/Cox4i1/Cox6a1/Atpif1 GO mitochondrial matrix 42/907 239/11442 7.09E-07 1.38E-05 1.26E-05 Tfb1m/Foxo3/Glrx5/Malsu1/Mrpl17/H2- Ke6/Mrpl11/Mrps28/Tsfm/Alkbh7/Glrx2/Mrpl58/Mrpl51/Mrpl2/Mrpl52/Mrpl54/ Mrps34/Clpp/Mrpl4/Etfb/Mrps24/Mrpl36/Dnajc19/Mrpl34/Mrpl55/Pin4/Bloc1s1 /Pam16/Mrps18a/Mrpl12/Mrpl33/Mrpl41/Mrps12/Mrps18c/Mrpl20/Rps3/Nduf ab1/Mrps21/Hspe1/Uqcc2/Park7/Ndufa7 GO ribonucleoside triphosphate 41/888 213/11253 6.61E-08 1.77E-05 1.77E-05 Rhoq/Slc25a33/Gphn/Sdhc/Coq7/Uqcc3/Pink1/Gm10250/Nme2/Nme1/Guk1/ metabolic process Ndufs6/Ndufv3/Uqcc2/Ndufa8/Park7/Atp5j2/Atp5l/Uqcrq/Atp5e/Cox7c/Ndufa 7/Atp5k/Cox5a/Atp5d/Atp5g3/Atp5o/Ndufb8/Ndufc2/Cox7a2/Mif/Atp5h/Chch d10/Uqcr10/Cox5b/Uqcrh/Ndufb6/Ndufb9/Cox4i1/Cox6a1/Atpif1 GO purine nucleoside triphosphate 41/888 215/11253 8.66E-08 2.18E-05 2.18E-05 Rhoq/Slc25a33/Gphn/Sdhc/Coq7/Uqcc3/Pink1/Gm10250/Nme2/Nme1/Guk1/ metabolic process Ndufs6/Ndufv3/Uqcc2/Ndufa8/Park7/Atp5j2/Atp5l/Uqcrq/Atp5e/Cox7c/Ndufa 7/Atp5k/Cox5a/Atp5d/Atp5g3/Atp5o/Ndufb8/Ndufc2/Cox7a2/Mif/Atp5h/Chch d10/Uqcr10/Cox5b/Uqcrh/Ndufb6/Ndufb9/Cox4i1/Cox6a1/Atpif1 GO ATP metabolic process 37/888 185/11253 1.04E-07 2.47E-05 2.47E-05 Slc25a33/Sdhc/Coq7/Uqcc3/Pink1/Gm10250/Guk1/Ndufs6/Ndufv3/Uqcc2/Ndu fa8/Park7/Atp5j2/Atp5l/Uqcrq/Atp5e/Cox7c/Ndufa7/Atp5k/Cox5a/Atp5d/Atp5 g3/Atp5o/Ndufb8/Ndufc2/Cox7a2/Mif/Atp5h/Chchd10/Uqcr10/Cox5b/Uqcrh/ Ndufb6/Ndufb9/Cox4i1/Cox6a1/Atpif1 GO rRNA processing 36/888 178/11253 1.16E-07 2.58E-05 2.58E-05 Tfb1m/Fbll1/Nvl/Gar1/Riok3/Gm10263/Gm10269/Ngdn/Wbp11/Trmt112/Gm9 493/Emg1/Frg1/Lsm6/Imp3/Ddx17/Nhp2/Gtf2h5/Pin4/Rpl35a/Nop10/Pop5/Rpl 14/Rps16/Rps8/Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rps21/Rps19/Rpl26/Rps 15/Rps14 GO mitochondrial proton- 9/907 17/11442 1.61E-06 2.94E-05 2.68E-05 Gm10250/Atp5j2/Atp5l/Atp5e/Atp5k/Atp5d/Atp5g3/Atp5o/Atp5h transporting ATP synthase complex GO proton-transporting ATP synthase 9/907 17/11442 1.61E-06 2.94E-05 2.68E-05 Gm10250/Atp5j2/Atp5l/Atp5e/Atp5k/Atp5d/Atp5g3/Atp5o/Atp5h complex GO cytochrome-c oxidase activity 9/880 15/11165 3.66E-07 3.02E-05 2.89E-05 Cox7c/Cox5a/Ndufa4/Cox7b/Cox7a2/Cox5b/Cox4i1/Cox6a1/Cox8a GO heme-copper terminal oxidase 9/880 15/11165 3.66E-07 3.02E-05 2.89E-05 Cox7c/Cox5a/Ndufa4/Cox7b/Cox7a2/Cox5b/Cox4i1/Cox6a1/Cox8a activity GO oxidoreductase activity, acting on 9/880 15/11165 3.66E-07 3.02E-05 2.89E-05 Cox7c/Cox5a/Ndufa4/Cox7b/Cox7a2/Cox5b/Cox4i1/Cox6a1/Cox8a a heme group of donors, oxygen as acceptor GO respiratory chain complex IV 7/907 10/11442 1.87E-06 3.29E-05 3.01E-05 Cox5a/Ndufa4/Cox7b/Cox4i1/Cox6b1/Cox6a1/Cox8a GO proton-transporting two-sector 13/907 37/11442 2.65E-06 4.53E-05 4.14E-05 Gm10250/Atp6v1d/Atp6v1g1/Atp5j2/Atp5l/Atp6v1f/Atp5e/Atp5k/Atp5d/Atp5g ATPase complex 3/Atp5o/Atp6v0b/Atp5h GO nucleoside triphosphate 42/888 230/11253 2.12E-07 4.49E-05 4.49E-05 Rhoq/Slc25a33/Gphn/Dctpp1/Sdhc/Coq7/Uqcc3/Pink1/Gm10250/Nme2/Nme1 metabolic process /Guk1/Ndufs6/Ndufv3/Uqcc2/Ndufa8/Park7/Atp5j2/Atp5l/Uqcrq/Atp5e/Cox7c/ Ndufa7/Atp5k/Cox5a/Atp5d/Atp5g3/Atp5o/Ndufb8/Ndufc2/Cox7a2/Mif/Atp5h /Chchd10/Uqcr10/Cox5b/Uqcrh/Ndufb6/Ndufb9/Cox4i1/Cox6a1/Atpif1 GO oxidoreductase activity, acting on 9/880 16/11165 7.77E-07 5.71E-05 5.45E-05 Cox7c/Cox5a/Ndufa4/Cox7b/Cox7a2/Cox5b/Cox4i1/Cox6a1/Cox8a a heme group of donors GO mitochondrial proton- 7/907 11/11442 4.78E-06 7.70E-05 7.04E-05 Gm10250/Atp5j2/Atp5l/Atp5k/Atp5g3/Atp5o/Atp5h transporting ATP synthase complex, coupling factor F(o) GO proton-transporting ATP synthase 7/907 11/11442 4.78E-06 7.70E-05 7.04E-05 Gm10250/Atp5j2/Atp5l/Atp5k/Atp5g3/Atp5o/Atp5h complex, coupling factor F(o) GO purine nucleoside 38/888 207/11253 7.00E-07 0.000134068 0.000134068 Slc25a33/Sdhc/Aprt/Coq7/Uqcc3/Pink1/Gm10250/Guk1/Ndufs6/Ndufv3/Uqcc2 monophosphate metabolic /Ndufa8/Park7/Atp5j2/Atp5l/Uqcrq/Atp5e/Cox7c/Ndufa7/Atp5k/Cox5a/Atp5d/ process Atp5g3/Atp5o/Ndufb8/Ndufc2/Cox7a2/Mif/Atp5h/Chchd10/Uqcr10/Cox5b/Uq crh/Ndufb6/Ndufb9/Cox4i1/Cox6a1/Atpif1 GO purine ribonucleoside 38/888 207/11253 7.00E-07 0.000134068 0.000134068 Slc25a33/Sdhc/Aprt/Coq7/Uqcc3/Pink1/Gm10250/Guk1/Ndufs6/Ndufv3/Uqcc2 monophosphate metabolic /Ndufa8/Park7/Atp5j2/Atp5l/Uqcrq/Atp5e/Cox7c/Ndufa7/Atp5k/Cox5a/Atp5d/ process Atp5g3/Atp5o/Ndufb8/Ndufc2/Cox7a2/Mif/Atp5h/Chchd10/Uqcr10/Cox5b/Uq crh/Ndufb6/Ndufb9/Cox4i1/Cox6a1/Atpif1 GO ribosomal small subunit 18/888 62/11253 7.86E-07 0.000143636 0.000143636 Riok3/Gm10263/Ngdn/Gm9493/Lsm6/Rps25/Rps5/Rps16/Rps8/Rps7/Rps17/Rp biogenesis s28/Rps21/Rps19/Rpl38/Rps15/Rps14/Rps27 Reactome Formation of ATP by 8/460 15/5641 7.10E-06 0.000174224 0.000151307 Atp5j2/Atp5l/Atp5e/Atp5k/Atp5d/Atp5g3/Atp5o/Atp5h chemiosmotic coupling Reactome Cristae formation 8/460 15/5641 7.10E-06 0.000174224 0.000151307 Atp5j2/Atp5l/Atp5e/Atp5k/Atp5d/Atp5g3/Atp5o/Atp5h GO NADH dehydrogenase 9/880 18/11165 2.86E-06 0.00017174 0.000164096 Ndufaf2/Ndufb7/Ndufs7/Ndufa5/Ndufa13/Ndufa7/Ndufa2/Ndufb8/Ndufc2 (ubiquinone) activity GO NADH dehydrogenase (quinone) 9/880 18/11165 2.86E-06 0.00017174 0.000164096 Ndufaf2/Ndufb7/Ndufs7/Ndufa5/Ndufa13/Ndufa7/Ndufa2/Ndufb8/Ndufc2 activity GO ribonucleoprotein complex 60/888 402/11253 9.89E-07 0.000168834 0.000168834 Tfb1m/Fbll1/Nvl/Gar1/Malsu1/Celf5/Zfp622/Gm10036/Riok3/Gm10263/Gm102 biogenesis 69/Ngdn/Mrpl11/Wbp11/Trmt112/Gm9493/Ipo4/Emg1/Frg1/Lsm6/Imp3/Nup8 8/Snrpd2/Ddx17/Srpk2/Luc7l3/Sf3b1/Nhp2/Mrpl36/Psip1/Lsm4/Gtf2h5/Gemin 7/Rpl23a- ps3/Pin4/Rpl23a/Rpl35a/Nop10/Pop5/Rps25/Rps5/Rpl14/Mrpl20/Rps16/Rps8/ Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rps21/Rps19/Rpl38/Rpl26/Rps15/Rpl13 a/Rpl24/Rps14/Rps27 GO ribonucleoside monophosphate 38/888 210/11253 1.02E-06 0.000168834 0.000168834 Slc25a33/Sdhc/Aprt/Coq7/Uqcc3/Pink1/Gm10250/Guk1/Ndufs6/Ndufv3/Uqcc2 metabolic process /Ndufa8/Park7/Atp5j2/Atp5l/Uqcrq/Atp5e/Cox7c/Ndufa7/Atp5k/Cox5a/Atp5d/ Atp5g3/Atp5o/Ndufb8/Ndufc2/Cox7a2/Mif/Atp5h/Chchd10/Uqcr10/Cox5b/Uq crh/Ndufb6/Ndufb9/Cox4i1/Cox6a1/Atpif1 GO energy derivation by oxidation of 36/888 194/11253 1.05E-06 0.000168834 0.000168834 Gsk3a/Ogdhl/Rb1cc1/Sdhc/Bax/Ppp1r1a/Coq7/Ndufaf2/Uqcc3/Bloc1s1/Sdhaf4 organic compounds /Pink1/S100b/Ndufs7/Ndufs6/Ndufa5/Ndufv3/Ndufa8/Park7/Cisd1/Uqcrq/Cox 7c/Ndufa7/Cox5a/Atp5d/Ndufb8/Ndufc2/Mt3/Uqcr10/Cox5b/Uqcrh/Ndufb6/M dh1/Ndufb9/Cox4i1/Cox6a1 GO rRNA metabolic process 37/888 204/11253 1.33E-06 0.000205285 0.000205285 Tfb1m/Fbll1/Nvl/Gar1/Riok3/Gm10263/Gm10269/Ngdn/Wbp11/Trmt112/Gm9 493/Emg1/Frg1/Lsm6/Imp3/Trir/Ddx17/Nhp2/Gtf2h5/Pin4/Rpl35a/Nop10/Pop 5/Rpl14/Rps16/Rps8/Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rps21/Rps19/Rpl2 6/Rps15/Rps14 GO nucleoside monophosphate 38/888 215/11253 1.85E-06 0.000275091 0.000275091 Slc25a33/Sdhc/Aprt/Coq7/Uqcc3/Pink1/Gm10250/Guk1/Ndufs6/Ndufv3/Uqcc2 metabolic process /Ndufa8/Park7/Atp5j2/Atp5l/Uqcrq/Atp5e/Cox7c/Ndufa7/Atp5k/Cox5a/Atp5d/ Atp5g3/Atp5o/Ndufb8/Ndufc2/Cox7a2/Mif/Atp5h/Chchd10/Uqcr10/Cox5b/Uq crh/Ndufb6/Ndufb9/Cox4i1/Cox6a1/Atpif1 GO NADH dehydrogenase activity 9/880 20/11165 8.54E-06 0.000470586 0.000449641 Ndufaf2/Ndufb7/Ndufs7/Ndufa5/Ndufa13/Ndufa7/Ndufa2/Ndufb8/Ndufc2 GO proton-transporting two-sector 8/907 18/11442 3.22E-05 0.00050484 0.000461687 Gm10250/Atp5j2/Atp5l/Atp5k/Atp5g3/Atp5o/Atp6v0b/Atp5h ATPase complex, proton- transporting domain Hallmark MYC_TARGETS_V1 35/277 190/3054 2.25E-05 0.000540134 0.000509336 Apex1/Hddc2/Trim28/Pabpc1/Snrpd2/Acp1/U2af1/Rpl22/Cbx3/Serbp1/Snrpg/ Nhp2/Srsf2/Lsm7/Pcbp1/Uba2/Ranbp1/Rack1/Rpl18/Psmc4/Vbp1/Rps5/Rpl14/ Psma7/Psmb2/Rps3/Ndufab1/Nme1/Psmb3/Hspe1/Ywhaq/Ywhae/H2afz/Cox5 a/Ppia GO mitochondrial electron transport, 9/888 19/11253 5.10E-06 0.000683768 0.000683768 Pink1/Ndufs6/Ndufa8/Park7/Ndufa7/Ndufb8/Ndufc2/Ndufb6/Ndufb9 NADH to ubiquinone GO energy coupled proton transport, 9/888 19/11253 5.10E-06 0.000683768 0.000683768 Gm10250/Atp5l/Atp5e/Atp5k/Atp5d/Atp5g3/Atp5o/Atp5h/Cox5b down electrochemical gradient GO ATP synthesis coupled proton 9/888 19/11253 5.10E-06 0.000683768 0.000683768 Gm10250/Atp5l/Atp5e/Atp5k/Atp5d/Atp5g3/Atp5o/Atp5h/Cox5b transport KEGG Cardiac muscle contraction 15/374 51/4117 2.70E-05 0.000740633 0.000735425 Tnnc1/Atp1b3/Uqcrq/Cox7c/Cox5a/Uqcr11/Cox7b/Cox7a2/Uqcr10/Cox5b/Uqc rh/Cox4i1/Cox6b1/Cox6a1/Cox8a GO generation of precursor 44/888 278/11253 6.16E-06 0.000799391 0.000799391 Gsk3a/Ogdhl/Rb1cc1/Slc25a33/Sdhc/Bax/Ppp1r1a/Coq7/Ndufaf2/Uqcc3/Bloc1 metabolites and energy s1/Sdhaf4/Pink1/S100b/Cox17/Ndufs7/Ndufs6/Ndufa5/Ndufv3/Uqcc2/Ndufb3/ Ndufa8/Park7/Cisd1/Uqcrq/Cox7c/Ndufa7/Cox5a/Atp5d/Atp5o/Ndufb8/Ndufc 2/Mt3/Cox7a2/Mif/Chchd10/Uqcr10/Cox5b/Uqcrh/Ndufb6/Mdh1/Ndufb9/Cox 4i1/Cox6a1 GO ribosomal small subunit assembly 9/888 20/11253 8.63E-06 0.001084107 0.001084107 Gm10263/Rps25/Rps5/Rps28/Rps19/Rpl38/Rps15/Rps14/Rps27 GO ATPase activity, coupled to 10/880 28/11165 3.10E-05 0.001502026 0.001435171 Gm10250/Atp6v1d/Atp5l/Atp6v1f/Atp5e/Atp5d/Atp5g3/Atp5o/Atp6v0b/Atp5h transmembrane movement of ions, rotational mechanism GO cation-transporting ATPase 13/880 46/11165 3.64E-05 0.001502026 0.001435171 Cpox/Atp1b3/Gm10250/Atp6v1d/Atp6v1g1/Atp5l/Atp6v1f/Atp5e/Atp5d/Atp5g activity 3/Atp5o/Atp6v0b/Atp5h GO active ion transmembrane 13/880 46/11165 3.64E-05 0.001502026 0.001435171 Cpox/Atp1b3/Gm10250/Atp6v1d/Atp6v1g1/Atp5l/Atp6v1f/Atp5e/Atp5d/Atp5g transporter activity 3/Atp5o/Atp6v0b/Atp5h GO ATPase coupled ion 13/880 46/11165 3.64E-05 0.001502026 0.001435171 Cpox/Atp1b3/Gm10250/Atp6v1d/Atp6v1g1/Atp5l/Atp6v1f/Atp5e/Atp5d/Atp5g transmembrane transporter 3/Atp5o/Atp6v0b/Atp5h activity GO proton-transporting ATP synthase 7/880 14/11165 3.87E-05 0.001504014 0.001437071 Gm10250/Atp5l/Atp5e/Atp5d/Atp5g3/Atp5o/Atp5h activity, rotational mechanism GO proteasome core complex 7/907 16/11442 0.000116 0.001771626 0.001620188 Psmb10/Psma5/Psmb4/Psma7/Psmb2/Psmb3/Psmb6 GO mitochondrial intermembrane 15/907 65/11442 0.000131 0.001948053 0.001781534 Cpox/Timm10b/Arl2/Bloc1s1/Timm13/Timm10/Pink1/Ndufb7/Cox17/Uqcc2/Nd space ufa8/Park7/Timm8b/Chchd10/Chchd2 GO organelle envelope lumen 16/907 73/11442 0.000152 0.002192259 0.002004866 Cpox/Timm10b/Arl2/Bloc1s1/Cacybp/Timm13/Timm10/Pink1/Ndufb7/Cox17/U qcc2/Ndufa8/Park7/Timm8b/Chchd10/Chchd2 GO oxidoreductase activity, acting on 9/880 25/11165 7.25E-05 0.002660552 0.002542131 Ndufaf2/Ndufb7/Ndufs7/Ndufa5/Ndufa13/Ndufa7/Ndufa2/Ndufb8/Ndufc2 NAD(P)H, quinone or similar compound as acceptor GO threonine-type endopeptidase 7/880 16/11165 0.000112 0.003702519 0.003537721 Psmb10/Psma5/Psmb4/Psma7/Psmb2/Psmb3/Psmb6 activity GO threonine-type peptidase activity 7/880 16/11165 0.000112 0.003702519 0.003537721 Psmb10/Psma5/Psmb4/Psma7/Psmb2/Psmb3/Psmb6 GO ribosome assembly 16/888 65/11253 3.21E-05 0.003913397 0.003913397 Gm10036/Gm10263/Mrpl11/Rpl23a- ps3/Rpl23a/Rps25/Rps5/Mrpl20/Rpl11/Rps28/Rps19/Rpl38/Rps15/Rpl24/Rps14 /Rps27 Reactome Autodegradation of Cdh1 by 14/460 59/5641 0.000204 0.004835831 0.004199729 Psme2b/Psme2/Ube2d1/Anapc11/Psmb10/Psmc4/Psma5/Psmb4/Rps27a/Psma Cdh1:APC/C 7/Psmb2/Psmb3/Psmb6/Uba52 GO ribosomal large subunit 17/888 73/11253 3.97E-05 0.004692398 0.004692398 Nvl/Malsu1/Zfp622/Gm10036/Gm10269/Mrpl11/Nhp2/Rpl23a- biogenesis ps3/Rpl23a/Rpl35a/Rpl14/Mrpl20/Rpl11/Rpl35/Rpl38/Rpl26/Rpl24 Reactome Macroautophagy 17/460 82/5641 0.000258 0.005894759 0.005119366 Rb1cc1/Dynll2/Atg101/Wdr45/Tomm6/Lamtor4/Chmp2a/Pink1/Tomm7/Dynll1 /Rps27a/Lamtor2/Gabarapl2/Tomm5/Lamtor5/Uba52/Map1lc3a Reactome Mitochondrial biogenesis 8/460 23/5641 0.000301 0.006646787 0.005772474 Atp5j2/Atp5l/Atp5e/Atp5k/Atp5d/Atp5g3/Atp5o/Atp5h GO copper ion binding 9/880 28/11165 0.000197 0.00621424 0.005937644 S100a13/Commd1/Ccs/Sncb/Atox1/Cuta/Cox17/Park7/Mt1 Reactome UCH proteinases 16/460 78/5641 0.000442 0.009447599 0.008204869 Psme2b/Tfpt/H2afj/Psme2/Psmb10/Psmc4/Psma5/Psmb4/Rps27a/Psma7/Psmb 2/Psmb3/Nedd8/Psmb6/Uba52/Uchl1 GO outer mitochondrial membrane 6/907 15/11442 0.000654 0.009226022 0.008437385 Mtx2/Mtx1/Tomm6/Pink1/Tomm7/Tomm5 protein complex Reactome APC/C-mediated degradation of 14/460 64/5641 0.000503 0.010108311 0.008778671 Psme2b/Psme2/Ube2d1/Anapc11/Psmb10/Psmc4/Psma5/Psmb4/Rps27a/Psma cell cycle proteins 7/Psmb2/Psmb3/Psmb6/Uba52 Reactome Regulation of mitotic cell cycle 14/460 64/5641 0.000503 0.010108311 0.008778671 Psme2b/Psme2/Ube2d1/Anapc11/Psmb10/Psmc4/Psma5/Psmb4/Rps27a/Psma 7/Psmb2/Psmb3/Psmb6/Uba52 Reactome DNA Replication 18/460 95/5641 0.000549 0.010714303 0.009304952 Psme2b/Rpa3/Rfc2/Psme2/Ube2d1/Anapc11/Psmb10/Psmc4/Psma5/Psmb4/Rp s27a/Rbx1/Psma7/Psmb2/Psmb3/Psmb6/Skp1a/Uba52 Reactome CDT1 association with the 12/460 51/5641 0.000627 0.01159558 0.010070306 Psme2b/Psme2/Psmb10/Psmc4/Psma5/Psmb4/Rps27a/Psma7/Psmb2/Psmb3/P CDC6:ORC:origin complex smb6/Uba52 Reactome Regulation of RUNX2 expression 5/460 10/5641 0.00063 0.01159558 0.010070306 Rps27a/Rbx1/Stub1/Skp1a/Uba52 and activity GO purine ribonucleotide metabolic 45/888 319/11253 9.11E-05 0.010459578 0.010459578 Rhoq/Nppc/Slc25a33/Gphn/Sdhc/Aprt/Coq7/Uqcc3/Pink1/Gm10250/Nme2/N process me1/Guk1/Ndufs6/Ndufv3/Uqcc2/Mpc2/Ndufa8/Park7/Atp5j2/Atp5l/Uqcrq/At p5e/Cox7c/Ndufa7/Atp5k/Cox5a/Atp5d/Atp5g3/Hint1/Atp5o/Ndufb8/Ndufc2/ Cox7a2/Mif/Atp5h/Chchd10/Uqcr10/Cox5b/Uqcrh/Ndufb6/Ndufb9/Cox4i1/Co x6a1/Atpif1 GO inner mitochondrial membrane 9/888 26/11253 0.000104 0.011624527 0.011624527 Bax/Uqcc3/Timm13/Timm10/Pink1/Chchd6/Romo1/Ndufa13/Chchd10 organization GO ribose phosphate metabolic 47/888 343/11253 0.00013 0.014169215 0.014169215 Rhoq/Nppc/Slc25a33/Pgls/Gphn/Sdhc/Aprt/Taldo1/Coq7/Uqcc3/Pink1/Gm102 process 50/Nme2/Nme1/Guk1/Ndufs6/Ndufv3/Uqcc2/Mpc2/Ndufa8/Park7/Atp5j2/Atp 5l/Uqcrq/Atp5e/Cox7c/Ndufa7/Atp5k/Cox5a/Atp5d/Atp5g3/Hint1/Atp5o/Nduf b8/Ndufc2/Cox7a2/Mif/Atp5h/Chchd10/Uqcr10/Cox5b/Uqcrh/Ndufb6/Ndufb9 /Cox4i1/Cox6a1/Atpif1 Reactome Cellular responses to external 44/460 338/5641 0.001061 0.018863995 0.016382639 Hist1h4i/Map2k7/Rpa3/Rb1cc1/Hist1h2bc/Dynll2/Dync1i2/Ccs/Nup88/Rps19bp stimuli 1/H2afj/Hikeshi/Ube2d1/Atg101/Wdr45/Anapc11/Dctn6/Tomm6/Lamtor4/Mt2/ Chmp2a/Pink1/Tomm7/Dynll1/Rps27a/Rbx1/Lamtor2/Txn1/Gabarapl2/Cryab/G px1/Tomm5/Eloc