Additional Table 1 Enriched pathways of upregulated DEGs by the phosphorylation deficient of CRMP2 (P <0.05, q <0.05) Database Description Ratio of DEGs Ratio of universe P -value P adjust q -value Gene name GO structural constituent of ribosome 77/880 170/11165 1.97E-40 1.30E-37 1.25E-37 Mrpl17/Gm10036/Rpl36- ps3/Gm10263/Mrpl11/Rps15a/Rps20/Mrpl51/Gm10073/Mrpl2/Mrpl52/Rpl22/M rpl54/Mrps34/Gm2000/Mrpl4/Mrps24/Mrpl36/Rpl28/Mrpl34/Mrpl55/Rpl29/Rpl 37rt/Rpl23a- ps3/Mrps18a/Mrpl12/Rpl23a/Rpl18/Rpl35a/Mrpl33/Mrpl41/Mrps12/Rps9/Rps1 8/Rps25/Rps5/Mrps18c/Rps27a/Rps26/Rplp2/Rpl14/Mrpl20/Rps3/Rps4x/Rps16 /Rpl37/Rpl37a/Rps8/Mrps21/Rpl36/Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rpl3 1/Rpl39/Rps13/Rps11/Rpl8/Fau/Rps21/Rps19/Rpl9/Rpl38/Rpl26/Rps15/Rpl13a/ Rpl41/Rpl24/Rpl19/Rps14/Ndufa7/Rps27/Rplp1/Rps29 GO ribosome 91/907 248/11442 2.51E-38 1.41E-35 1.29E-35 Malsu1/Mrpl17/Zfp622/Gm10036/Rpl36- ps3/Gm10263/Gm10269/Mrpl11/Mrps28/Gm9493/Rpl13- ps3/Rps15a/Mrpl58/Rps20/Mrpl51/Gm10073/Mrpl2/Mrpl52/Rpl22/Mrpl54/Mrp s34/Gm2000/Mrpl4/Mrps24/Mrpl36/Rpl28/Mrpl34/Mrpl55/Rpl29/Rpl37rt/Rpl23 a- ps3/Rack1/Mrps18a/Mrps33/Mrpl12/Rpl23a/Rpl18/Rpl35a/Aurkaip1/Mrpl33/Btf 3/Mrpl41/Mrps12/Rpl36a/Rps9/Rps18/Rps25/Rps5/Mrps18c/Rps27a/Rps26/Rpl p2/Rpl14/Mrpl20/Rps3/Ndufab1/Rps4x/Rps16/Rpl37/Rpl37a/Rps8/Mrps21/Rpl 36/Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rpl31/Rpl39/Rps13/Rps11/Rpl8/Fau/ Rps21/Rps19/Rpl9/Rpl38/Rpl26/Rps15/Rpl13a/Uba52/Rpl41/Rpl24/Rpl19/Rps1 4/Ndufa7/Rps27/Rplp1/Rps29 GO ribosomal subunit 84/907 215/11442 8.01E-38 2.26E-35 2.07E-35 Malsu1/Mrpl17/Zfp622/Gm10036/Rpl36- ps3/Gm10263/Gm10269/Mrpl11/Mrps28/Gm9493/Rpl13- ps3/Rps15a/Mrpl58/Rps20/Mrpl51/Gm10073/Mrpl2/Mrpl52/Rpl22/Mrpl54/Mrp s34/Mrpl4/Mrps24/Mrpl36/Rpl28/Mrpl34/Mrpl55/Rpl29/Rpl23a- ps3/Rack1/Mrps18a/Mrpl12/Rpl23a/Rpl18/Rpl35a/Mrpl33/Mrpl41/Mrps12/Rpl3 6a/Rps9/Rps18/Rps25/Rps5/Mrps18c/Rps27a/Rps26/Rplp2/Rpl14/Mrpl20/Rps3 /Ndufab1/Rps4x/Rps16/Rpl37/Rpl37a/Rps8/Mrps21/Rpl36/Rpl11/Rps7/Rps17/R pl35/Rpl27/Rps28/Rpl31/Rpl39/Rps13/Rps11/Rpl8/Fau/Rps21/Rps19/Rpl9/Rpl3 8/Rpl26/Rps15/Rpl13a/Uba52/Rpl24/Rpl19/Rps14/Rps27/Rplp1/Rps29 KEGG Ribosome 63/374 118/4117 3.60E-36 8.88E-34 8.82E-34 Mrpl17/Mrpl11/Rps15a/Rps20/Rpl34/Rpl34- ps1/Gm4705/Mrpl2/Rpl22/Rps27/Rps27rt/Mrpl4/Mrpl36/Rpl28/Mrpl34/Rpl29/ Gm8210/Rpl37/Rpl37rt/Mrps18a/Mrpl12/Rpl23a/Rpl18/Rpl35a/Mrpl33/Mrps12/ Rpl36a/Rpl36al/Rps9/Rps18/Rps25/Rps5/Mrps18c/Rps27a/Rps26/Rplp2/Rpl14/ Mrpl20/Rps3/Rps4x/Rps16/Rpl37a/Rps8/Mrps21/Rpl36/Rpl11/Rps7/Rps17/Rpl3 5/Rpl27/LOC108167922/Rps28/Rpl31/Rpl39/Rps13/Rps11/Rpl8/Fau/Rps21/Rps 19/Rpl9/Rpl38/Rpl26/Rpl13a/Uba52/Rpl41/Rpl24/Rps14/Rplp1/Rps29 Reactome SRP-dependent cotranslational 52/460 84/5641 2.25E-36 1.49E-33 1.30E-33 Rps15a/Rps20/Rpl34- protein targeting to membrane ps1/Rpl22/Rps27rt/Rpl28/Rpl29/Rpl37rt/Rpl23a/Rpl18/Rpl35a/Rpl36a/Rps9/Rps 18/Rps25/Rps5/Rps27a/Rps26/Rplp2/Rpl14/Rps3/Rps4x/Rps16/Rpl37/Rps8/Rpl 36al/Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rpl31/Rpl39/Rps13/Rps11/Rpl8/Sr p14/Rps21/Rps19/Rpl9/Rpl38/Rpl26/Rps15/Rpl13a/Uba52/Rpl24/Rpl19/Rps14/ Rps27/Rplp1/Rps29 Reactome Nonsense Mediated Decay (NMD) 52/460 85/5641 5.38E-36 1.78E-33 1.55E-33 Rps15a/Pabpc1/Rps20/Rpl34- independent of the Exon Junction ps1/Rpl22/Rps27rt/Rpl28/Rpl29/Rpl37rt/Rpl23a/Rpl18/Rpl35a/Rpl36a/Rps9/Rps Complex (EJC) 18/Rps25/Rps5/Rps27a/Rps26/Rplp2/Rpl14/Rps3/Rps4x/Rps16/Rpl37/Rps8/Rpl 36al/Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rpl31/Rpl39/Rps13/Rps11/Rpl8/Rp s21/Rps19/Rpl9/Rpl38/Rpl26/Rps15/Rpl13a/Uba52/Rpl24/Rpl19/Rps14/Rps27/ Rplp1/Rps29 GO mitochondrial protein complex 86/907 241/11442 3.63E-35 6.82E-33 6.23E-33 Malsu1/Mrpl17/Mrpl11/Mrps28/Mrpl58/Mtx2/Mrpl51/Sdhc/Mtx1/Timm10b/Mr pl2/Mrpl52/Mrpl54/Mrps34/Mrpl4/Bax/Etfb/Mrps24/Mrpl36/Dnajc19/Dmac1/T omm6/Mrpl34/Mrpl55/Uqcc3/Ndufa11/Pam16/Mrps18a/Mrpl12/Mrpl33/Timm 13/Timm10/Pink1/Tomm7/Mrpl41/Mrps12/Gm10250/Ndufb2/Mrps18c/Ndufa6 /Ndufb4/Mrpl20/Chchd6/Ndufab1/Ndufb11/Ndufb7/Ndufc1/Mrps21/Romo1/T omm5/Ndufs7/Ndufs6/Smdt1/Ndufa5/Ndufv3/Ndufb3/Ndufa8/Ndufb5/Park7/ Ndufa13/Atp5j2/Atp5l/Ndufb10/Uqcrq/Atp5e/Ndufa3/Ndufa7/Atp5k/Cox5a/At p5d/Ndufa2/Ndufa1/Atp5g3/Atp5o/Ndufb8/Ndufs5/Ndufa4/Ndufc2/Atp5h/Ch chd10/Uqcr10/Uqcrh/Ndufb6/Ndufb9/Cox4i1/Cox6a1 Reactome Translation 80/460 216/5641 2.47E-34 5.45E-32 4.73E-32 Mrpl17/Mrpl11/Trmt112/Mrps28/Eif2b2/Rps15a/Mrpl58/Pabpc1/Rps20/Mrpl51 /Rpl34- ps1/Mrpl2/Mrpl52/Rpl22/Mrpl54/Mrps34/Rps27rt/Mrpl4/Mrps24/Mrpl36/Rpl28 /Eif3f/Mrpl34/Mrpl55/Rpl29/Rpl37rt/Mrps18a/Mrps33/Mrpl12/Rpl23a/Rpl18/Rp l35a/Aurkaip1/Mrpl33/Mrpl41/Mrps12/Rpl36a/Rps9/Rps18/Rps25/Rps5/Mrps18 c/Rps27a/Rps26/Rplp2/Rpl14/Mrpl20/Rps3/Rps4x/Rps16/Rpl37/Rps8/Rpl36al/ Mrps21/Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rpl31/Rpl39/Rps13/Rps11/Rpl8 /Srp14/Rps21/Rps19/Rpl9/Rpl38/Rpl26/Rps15/Rpl13a/Uba52/Rpl24/Rpl19/Rps1 4/Rps27/Rplp1/Rps29 Reactome Formation of a pool of free 40S 52/460 93/5641 3.15E-33 5.23E-31 4.54E-31 Rps15a/Rps20/Rpl34- subunits ps1/Rpl22/Rps27rt/Rpl28/Eif3f/Rpl29/Rpl37rt/Rpl23a/Rpl18/Rpl35a/Rpl36a/Rps 9/Rps18/Rps25/Rps5/Rps27a/Rps26/Rplp2/Rpl14/Rps3/Rps4x/Rps16/Rpl37/Rps 8/Rpl36al/Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rpl31/Rpl39/Rps13/Rps11/Rpl 8/Rps21/Rps19/Rpl9/Rpl38/Rpl26/Rps15/Rpl13a/Uba52/Rpl24/Rpl19/Rps14/Rp s27/Rplp1/Rps29 GO cytosolic ribosome 60/907 132/11442 1.28E-31 1.80E-29 1.65E-29 Zfp622/Gm10036/Rpl36-ps3/Gm10263/Gm10269/Gm9493/Rpl13- ps3/Rps15a/Rps20/Gm10073/Rpl22/Rpl28/Rpl29/Rpl23a- ps3/Rack1/Rpl23a/Rpl18/Rpl35a/Rpl36a/Rps9/Rps18/Rps25/Rps5/Rps27a/Rps2 6/Rplp2/Rpl14/Rps3/Rps4x/Rps16/Rpl37/Rpl37a/Rps8/Rpl36/Rpl11/Rps7/Rps17 /Rpl35/Rpl27/Rps28/Rpl31/Rpl39/Rps13/Rps11/Rpl8/Fau/Rps21/Rps19/Rpl9/Rp l38/Rpl26/Rps15/Rpl13a/Uba52/Rpl24/Rpl19/Rps14/Rps27/Rplp1/Rps29 Reactome L13a-mediated translational 53/460 103/5641 2.10E-31 2.79E-29 2.42E-29 Rps15a/Pabpc1/Rps20/Rpl34- silencing of Ceruloplasmin ps1/Rpl22/Rps27rt/Rpl28/Eif3f/Rpl29/Rpl37rt/Rpl23a/Rpl18/Rpl35a/Rpl36a/Rps expression 9/Rps18/Rps25/Rps5/Rps27a/Rps26/Rplp2/Rpl14/Rps3/Rps4x/Rps16/Rpl37/Rps 8/Rpl36al/Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rpl31/Rpl39/Rps13/Rps11/Rpl 8/Rps21/Rps19/Rpl9/Rpl38/Rpl26/Rps15/Rpl13a/Uba52/Rpl24/Rpl19/Rps14/Rp s27/Rplp1/Rps29 Reactome Nonsense-Mediated Decay 53/460 104/5641 3.97E-31 3.76E-29 3.27E-29 Rps15a/Pabpc1/Rps20/Rpl34- (NMD) ps1/Eif4a3/Rpl22/Rps27rt/Rpl28/Rpl29/Rpl37rt/Rpl23a/Rpl18/Rpl35a/Rpl36a/Rp s9/Rps18/Rps25/Rps5/Rps27a/Rps26/Rplp2/Rpl14/Rps3/Rps4x/Rps16/Rpl37/Rp s8/Rpl36al/Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rpl31/Rpl39/Rps13/Rps11/R pl8/Rps21/Rps19/Rpl9/Rpl38/Rpl26/Rps15/Rpl13a/Uba52/Rpl24/Rpl19/Rps14/R ps27/Rplp1/Rps29 Reactome Nonsense Mediated Decay (NMD) 53/460 104/5641 3.97E-31 3.76E-29 3.27E-29 Rps15a/Pabpc1/Rps20/Rpl34- enhanced by the Exon Junction ps1/Eif4a3/Rpl22/Rps27rt/Rpl28/Rpl29/Rpl37rt/Rpl23a/Rpl18/Rpl35a/Rpl36a/Rp Complex (EJC) s9/Rps18/Rps25/Rps5/Rps27a/Rps26/Rplp2/Rpl14/Rps3/Rps4x/Rps16/Rpl37/Rp s8/Rpl36al/Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rpl31/Rpl39/Rps13/Rps11/R pl8/Rps21/Rps19/Rpl9/Rpl38/Rpl26/Rps15/Rpl13a/Uba52/Rpl24/Rpl19/Rps14/R ps27/Rplp1/Rps29 GO inner mitochondrial membrane 54/907 108/11442 3.22E-31 3.63E-29 3.32E-29 Sdhc/Timm10b/Dnajc19/Dmac1/Uqcc3/Ndufa11/Pam16/Timm10/Gm10250/Nd protein complex ufb2/Ndufa6/Ndufb4/Chchd6/Ndufab1/Ndufb11/Ndufb7/Ndufc1/Romo1/Nduf s7/Ndufs6/Smdt1/Ndufa5/Ndufv3/Ndufb3/Ndufa8/Ndufb5/Park7/Ndufa13/Atp 5j2/Atp5l/Ndufb10/Uqcrq/Atp5e/Ndufa3/Ndufa7/Atp5k/Cox5a/Atp5d/Ndufa2/ Ndufa1/Atp5g3/Atp5o/Ndufb8/Ndufs5/Ndufa4/Ndufc2/Atp5h/Chchd10/Uqcr1 0/Uqcrh/Ndufb6/Ndufb9/Cox4i1/Cox6a1 Reactome Eukaryotic Translation Initiation 54/460 111/5641 2.26E-30 1.67E-28 1.45E-28 Eif2b2/Rps15a/Pabpc1/Rps20/Rpl34- ps1/Rpl22/Rps27rt/Rpl28/Eif3f/Rpl29/Rpl37rt/Rpl23a/Rpl18/Rpl35a/Rpl36a/Rps 9/Rps18/Rps25/Rps5/Rps27a/Rps26/Rplp2/Rpl14/Rps3/Rps4x/Rps16/Rpl37/Rps 8/Rpl36al/Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rpl31/Rpl39/Rps13/Rps11/Rpl 8/Rps21/Rps19/Rpl9/Rpl38/Rpl26/Rps15/Rpl13a/Uba52/Rpl24/Rpl19/Rps14/Rp s27/Rplp1/Rps29 Reactome Cap-dependent Translation 54/460 111/5641 2.26E-30 1.67E-28 1.45E-28 Eif2b2/Rps15a/Pabpc1/Rps20/Rpl34- Initiation ps1/Rpl22/Rps27rt/Rpl28/Eif3f/Rpl29/Rpl37rt/Rpl23a/Rpl18/Rpl35a/Rpl36a/Rps 9/Rps18/Rps25/Rps5/Rps27a/Rps26/Rplp2/Rpl14/Rps3/Rps4x/Rps16/Rpl37/Rps 8/Rpl36al/Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rpl31/Rpl39/Rps13/Rps11/Rpl 8/Rps21/Rps19/Rpl9/Rpl38/Rpl26/Rps15/Rpl13a/Uba52/Rpl24/Rpl19/Rps14/Rp s27/Rplp1/Rps29 Reactome GTP hydrolysis and joining of the 52/460 104/5641 5.11E-30 3.39E-28 2.94E-28 Rps15a/Rps20/Rpl34- 60S ribosomal subunit ps1/Rpl22/Rps27rt/Rpl28/Eif3f/Rpl29/Rpl37rt/Rpl23a/Rpl18/Rpl35a/Rpl36a/Rps 9/Rps18/Rps25/Rps5/Rps27a/Rps26/Rplp2/Rpl14/Rps3/Rps4x/Rps16/Rpl37/Rps 8/Rpl36al/Rpl11/Rps7/Rps17/Rpl35/Rpl27/Rps28/Rpl31/Rpl39/Rps13/Rps11/Rpl 8/Rps21/Rps19/Rpl9/Rpl38/Rpl26/Rps15/Rpl13a/Uba52/Rpl24/Rpl19/Rps14/Rp s27/Rplp1/Rps29 KEGG Oxidative phosphorylation 51/374 95/4117 1.98E-29 2.45E-27 2.43E-27 Sdhc/Ndufa11/Ndufb2/Atp6v1d/Ndufa6/Ndufb4/Ndufb4c/Ndufb4b/Ndufab1/ Ndufb11/Ndufb7/Ndufc1/Atp6v1g1/Cox17/Ndufs7/Ndufs6/Ndufv3/Ndufb3/N dufa8/Ndufb5/Ndufa13/Atp5j2/Atp5l/Ndufb10/Uqcrq/Atp6v1f/Atp5e/Cox7c/N dufa3/Ndufa7/Atp5k/Cox5a/Ndufa2/Ndufa1/Atp5g3/Uqcr11/Atp5o/Ndufs5/Nd ufa4/Ndufc2/Cox7b/Cox7a2/Atp6v0b/Atp5h/Uqcr10/Cox5b/Uqcrh/Ndufb6/Nd ufb9/Cox4i1/Cox6b1/Cox6a1/Cox8a GO respiratory chain 42/907 69/11442 3.32E-29 3.12E-27 2.86E-27 Sdhc/Dmac1/Uqcc3/Ndufa11/Ndufb2/Ndufa6/Ndufb4/Ndufab1/Ndufb11/Nduf b7/Ndufc1/Ndufs7/Ndufs6/Ndufa5/Ndufv3/Ndufb3/Ndufa8/Ndufb5/Park7/Nd ufa13/Ndufb10/Uqcrq/Ndufa3/Ndufa7/Cox5a/Ndufa2/Ndufa1/Uqcr11/Ndufb8 /Ndufs5/Ndufa4/Ndufc2/Cox7b/Cox7a2/Uqcr10/Uqcrh/Ndufb6/Ndufb9/Cox4i1 /Cox6b1/Cox6a1/Cox8a GO respiratory chain complex 40/907 63/11442 6.57E-29 5.29E-27 4.84E-27 Sdhc/Dmac1/Uqcc3/Ndufa11/Ndufb2/Ndufa6/Ndufb4/Ndufab1/Ndufb11/Nduf