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Diabetes

Drug Class Examples How the Works y decreases the ’s glucose production and q Glucophage, Glucophage XR – resistance in liver, muscle and fat cells q Other: ______y may also improve lipid (fat) levels

Sulfonylureas y stimulates the to produce and release q Glucotrol, Glucotrol XL – more insulin q Amaryl – y can be long-acting and may stay in the body up to q Other: ______72 hours, but most last 24 hours or less SGLT2 Inhibitors y lowers blood sugar by causing the kidneys to remove q Invokana – q Jardiance – sugar from the body through the urine q Farxiga – q Steglatro – DPP-4 Inhibitors y increases the body’s release of insulin in response to a rise q Januvia – q Onglyza – in glucose levels q Nesina – q Tradjenta – y prolongs action of gut hormornes q Other: ______y delays gastric (stomach) emptying TZDs – y increases insulin sensitivity in muscle and fat cells q Avandia – y helps decrease production of glucose in the liver and q Actos – improve blood lipid (fat) levels Alpha-glucosidase Inhibitors y slows down the digestion of certain , which q Precose – can help keep blood sugar levels from rising q Glyset –

Meglitinides (Can cause low blood sugar) y causes a burst of insulin to be released when you eat q Prandin – a meal q Starlix – y has a short time of action for mealtime use q Other: ______

Dopamine Receptor Agonists y helps lower blood sugar levels after a meal q Cycloset and Parlodel – BASs – Bile Acid Sequestrants y a cholesterol-lowering medication that also reduces blood q Welchol – colesevalam sugar levels in patients with

GLP1 – Mimetics (Injectable hormones) y increases insulin release with food, slows gastric emptying q Trulicity – and promotes feeling of fullness. Also helps suppress q Byetta – , Bydureon – exenatide XR glucose from being released by liver and can help with q Victoza – weight loss q Other: ______y regulates insulin production in the pancreas and the release of glucose in the bloodstream (These are versions of natural hormones.) y taken as injections

Insulin (Can cause low blood sugar) y regulates blood sugar if the pancreas can’t produce q Rapid-acting – NovoLog® – aspart, Humalog – lispro enough insulin q Regular or short-acting – Humulin R, Novolin R y usually taken by injection or pump q Intermediate-acting – NPH (Neutral Protamine Hagedom) y more than one type may need to be taken – isophane y rapid acting (bolus) insulin lowers after-meal blood sugar q Long-acting – Levemir – detemir, Lantus – glargine, y intermediate or long-acting (basal) insulin control blood Tresiba – degludec sugar between meal and overnight

This chart does not imply endorsement of any type or brand of . It does not list side effects, adverse reactions, interactions or precautions. Only a doctor can recommend or prescribe these medications. Medications in these classes can cause low blood sugar. The U.S. Food and Administration has approved the medications in this chart. Visit www.tricare.mil and www.express-scripts.com/tricare for current benefit and prescription information. Source: American Diabetes Association at https://professional.diabetes.org/sites/professional.diabetes.org/files/pel/source/medications.pdf and https://www.diabetes.org/diabetes/medication-management/oral-medication/what-are-my-options This document is for general information only and is not intended as a substitute for professional medical care. www.tricare-west.com

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