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Here Will Be Over 100 Lectures and a Plenary Round Table Session, the Latter Focusing on the Hot Topic of the Mitochondrial Permeability Transition Pore

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Here Will Be Over 100 Lectures and a Plenary Round Table Session, the Latter Focusing on the Hot Topic of the Mitochondrial Permeability Transition Pore Welcome Address It is our great pleasure and honour to welcome you in Budapest, Hungary on the occasion of the 20th European Bioenergetics Conference. Bioenergeticists from the whole world – not only from Europe – gather every other year to present the most exciting developments from the molecular and atomic resolution details of the machinery involved in the chemiosmotic conversion of light and chemical energy to the physiology and pathology connected to the energy metabolism of cells, with mitochondria occupying the central stage. This year’s EBEC is organized and hosted by the medical school of Budapest, Semmelweis University – celebrating the 200th birthday of its denominator, Semmelweis Ignác in 2018 and the 250th anniversary of its foundation in 2019 – and co-organized by the Biological Research Centre of the Hungarian Academy of Sciences. The aim of the conference is to promote research in, and interaction between the diverse fields ranging from biophysics to medical sciences, and to encourage students and early career investigators to stay involved and build connections with colleagues and leading experts in bioenergetics. EBEC2018 will be attended by approximately 400 delegates. We are pleased to announce the Peter Mitchell Medal acceptance lecture by Etana Padan from the Hebrew University, Jerusalem, who was awarded this prestigious prize by the Mitchell medal committee formed by previous awardees. With nine plenary and sixteen parallel sessions organized, there will be over 100 lectures and a plenary round table session, the latter focusing on the hot topic of the mitochondrial permeability transition pore. Plenty of time will be allocated for viewing the over 250 posters presented by the delegates. We are grateful to members of the International Advisory Committee of EBEC for their suggestions for speakers and to session chairs for volunteering or accepting our invitation. We are also grateful to our sponsors and supporting organizations for their generous financial contributions, especially to assist the participation of students and young investigator. Last but not least, we are indebted to all of you, who bring the latest and most exciting science to EBEC2018! It only remains for us to wish you a successful conference and a memorable stay in Budapest, the capital city of Hungary. László Tretter László Zimányi Organizer of EBEC2018 Co-organizer of EBEC2018 Department of Medical Biochemistry Institute of Biophysics Biological Research Centre, Semmelweis University, Budapest Hungarian Academy of Sciences, Szeged PREVIOUS EUROPEAN BIOENERGETICS CONFERENCES NEXT EUROPEAN BIOENERGETICS CONFERENCE 1980 Urbino, Italy 1982 Lyon, France 2020 Marseille, France 1984 Hannover, Germany 1986 Prague, Czech Republic 1988 Aberystwyth, United Kingdom MITCHELL MEDAL AWARDEES 1990 Noordwijkerout, The Netherlands 1992 Helsinki, Finland 1994 P. Leslie DUTTON 1994 Valencia, Spain 1996 John E. WALKER 1996 Louvain-la-Neuve, Belgium 1998 Wolfgang JUNGE 1998 Göteborg, Sweden 2000 Mårten WIKSTRÖM 2000 Brighton, United Kingdom 2002 Horst WITT 2002 Arcachon, France 2004 Hartmut MICHEL 2004 Pisa, Italy 2006 Masasuke YOSHIDA 2006 Moscow, Russian Federation 2008 David G. NICHOLLS 2008 Dublin, Ireland 2010 Dieter OESTERHELT 2010 Warsaw, Poland 2012 H. Ronald KABACK 2012 Freiburg, Germany 2014 Robert B. GENNIS 2014 Lisbon, Portugal 2016 Peter RICH 2016 Riva del Garda, Italy 2018 Etana PADAN COMMITTEES AND ORGANISATION Carola HUNTE, Germany Local Organizing Committee Cesare INDIVERI, Italy László TRETTER, László ZIMÁNYI Amandine MARÉCHAL, UK Attila AMBRUS Anthony L. MOORE, UK Christos CHINOPOULOS Plácido NAVAS LLORET, Spain Andras EKE David G. NICHOLLS, USA Beata TOROCSIK Wolfgang NITSCHKE, France Artur OSYCZKA, Poland Scientific Committee Etana PADAN, Israel Paolo BERNARDI, Italy Manuela PEREIRA, Portugal Peter BRZEZINSKI, Sweden Eduardo RIAL, Spain Gary CECCHINI, USA Peter R. RICH, UK Andrei D. VINOGRADOV, Russia Barbara SCHOEPP-COTHENET, France P. Leslie DUTTON, USA Adam SZEWCZYK, Poland Thorsten FRIEDRICH, Germany László TRETTER, Hungary Robert GENNIS, USA Salvador URIBE-CARVAJAL, Mexico Alessandro GIUFFRÈ, Italy John E. WALKER, UK Erich B. GNAIGER, Austria Mårten WIKSTRÖM, Finland Joachim HEBERLE, Germany László ZIMÁNYI, Hungary INVITED SPEAKERS AND CHAIRS Wayne D. FRASCH USA Pia ÄDELROTH Sweden Christian FREZZA United Kingdom Ulrike ALEXIEV Germany Thorsten FRIEDRICH Germany Susanne ARNOLD The Netherlands Győző GARAB Hungary Peter BAI Hungary José J. GARCIA-TREJO Mexico Robert BALABAN USA Robert B. GENNIS USA Alessandra BARACCA Italy Akos GERENCSER Hungary Paolo BERNARDI Italy Christoph GERLE Japan Giancarlo A. BIAGINI Italy Erich GNAIGER Austria Juan Pedro BOLAÑOS Spain György HAJNOCZKY USA Michael BÖRSCH Germany Joachim HEBERLE Germany Ulrich BRANDT Germany Etienne HEBERT-CHATELAIN Canada Leonid S. BROWN Canada Judy HIRST United Kingdom Peter BRZEZINSKI Sweden Daniel Ken INAOKA Japan Karin B. BUSCH Germany Cesare INDIVERI Italy Susana CADENAS Spain Naotada ISHIHARA Japan Gary CECCHINI USA Petr JEŽEK Czech Republic Quan CHEN China Elizabeth Ann JONAS USA Christos CHINOPOULOS Hungary Frank JORDAN USA Stirling CHURCHMAN USA Ville R.I. KAILA Germany Vito DE PINTO Italy Hideki KANDORI Japan Norbert A. DENCHER Germany Pekka KATAJISTO Finland José FARALDO-GOMEZ USA Yuriy KIRICHOK USA Shelagh FERGUSON-MILLER USA Werner J.H. KOOPMAN The Netherlands David FERRICK USA Andrey V. KOZLOV Austria Giovanni FINAZZI France Werner KUEHLBRANDT Germany Edmund R.S. KUNJI United Kingdom Alberto SANZ United Kingdom Genji KURISU Japan Leonid SAZANOV Austria Petar H. LAMBREV Hungary Luca SCORRANO Italy Mei LI China Thomas N. SEYFRIED USA Wei LI China Jian-Ren SHEN Japan Michael P. LISANTI United Kingdom Keshav K. SINGH USA William MARTIN Germany Giancarlo SOLAINI Italy Hartmut MICHEL Germany Alexei A. STUCHEBRUKHOV USA Francis MILLET USA Ildikó SZABÓ Italy Anthony L. MOORE United Kingdom Adam SZEWCZYK Poland Jan NEDERGAARD Sweden Marten SZIBOR Finland Nathan NELSON Israel Ye TIAN China Richard NEUTZE Sweden László TRETTER Hungary David G. NICHOLLS USA Salvador URIBE-CARVAJAL Mexico Artur OSYCZKA Poland Rienk VAN GRONDELLE The Netherlands Etana PADAN Israel Andrei VINOGRADOV Russian Federtion Luigi PALMIERI Italy Carlo VISCOMI United Kingdom Manuela PEREIRA Portugal Sir John E. WALKER United Kingdom Nikolaus PFANNER Germany Douglas C. WALLACE USA Peter POHL Austria Mårten WIKSTRÖM Finland Richard PORTER Ireland Richard J. YOULE USA Zsolt RADAK Hungary László ZIMÁNYI Hungary Andrea RASOLA Italy Peter R. RICH United Kingdom Rodrigue ROSSIGNOL France Ann SAADA (REISCH) Israel SCIENTIFIC PROGRAM SCIENTIFIC PROGRAMME Saturday 25 August, 2018 16:30 OPENING CEREMONY 17:00 MITCHELL MEDAL PLENARY Chair: Robert B. Gennis The NhaA Na+/H+ antiporter, new insight into structural and functional dynamics Etana Padan Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, Israel 18:00 OPENING PLENARY Chair: László Zimányi Sixty-five years of the mitochondrial permeability transition: Past, present and future Paolo Bernardi Department of Biomedical Sciences, University of Padova, and Consiglio Nazionale delle Ricerche, Institute of Neuroscience, Padova, Italy 19:00 WELCOME RECEPTION SCIENTIFIC PROGRAM Sunday 26 August, 2018 08:20 PLENARY IV.A. MITOCHONDRIA AND CANCER Chair: László Tretter 08:20 Metabolic management of Glioblastoma (30+10’) Thomas N. Seyfried Department of Biology, Boston College, Chestnut Hill, Massachusetts, United States 09:00 PLENARY I. MACROMOLECULAR STRUCTURE AND FUNCTION 1 Chair: Thorsten Friedrich 09:00 Cryo-EM structures of complex I from mouse heart mitochondria in biochemically-defined states (30+10’) Judy Hirst MRC Mitochondrial Biology Unit, University of Cambridge, United Kingdom 09:40 Structure of the alternative complex III in a supercomplex with cytochrome oxidase (30+10’) Robert B. Gennis Department of Biochemistry, University of Illinois, Urbana, USA 10:20 Regulation, functional analysis and assembly of dimeric ATP synthases in mitochondria (30+10’) John E. Walker MRC Mitochondrial Biology Unit, Cambridge, United Kingdom 11:00 Coffee Break 11:30 PLENARY II. MACROMOLECULAR STRUCTURE AND FUNCTION 2 Chair: Peter Pohl 11:30 Cytochrome c oxidase – a molecular machine (30+10’) Mårten Wikström Institute of Biotechnology, University of Helsinki, Finland SCIENTIFIC PROGRAM 12:10 Terminal oxidases of the heme-copper and bd oxidase type, a structural and functional comparison (30+10’) Hartmut Michel Department of Molecular Membrane Biology, Max Planck Institute of Biophysics, Frankfurt am Main, Germany 12:50 CryoEM structures of ATP synthase (30+10’) Werner Kühlbrandt Max Planck Institute of Biophysics, Department of Structural Biology, Frankfurt am Main, Germany 13:30 LUNCH and POSTER VIEWING 1. ROOM "A" ROOM "B" 15:00 1A. QUINONE REDUCTASES 15:00 1B. OXIDATIVE STRESS Chair: Alexei A. Stuchebrukhov Chair: Andrei Vinogradov 15:00 Tweaking the gearbox: the mechanism and 15:00 Human 2-oxo acid dehydrogenase multienzyme complexes: regulation of mitochondrial complex I (20+5’) experimental observation of the thiamin diphosphate- Ulrich Brandt enamine radical species and its contribution to generation of Radboud University Medical Center, Nijmegen, superoxide and hydrogen peroxide in vitro (20+5’) Netherlands; University of Cologne, Germany Frank Jordan Department of Chemistry, Rutgers University, Newark, New Jersey 07102-1811, USA 15:25 Coupling mechanism of complex I (20+5’) 15:25 Site-specific ROS signalling during ageing (20+5’) Leonid
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