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BMJ Open Is Committed to Open Peer Review. As Part of This Commitment We Make the Peer Review History of Every Article We Publish Publicly Available BMJ Open: first published as 10.1136/bmjopen-2020-038909 on 28 December 2020. Downloaded from BMJ Open is committed to open peer review. As part of this commitment we make the peer review history of every article we publish publicly available. When an article is published we post the peer reviewers’ comments and the authors’ responses online. We also post the versions of the paper that were used during peer review. These are the versions that the peer review comments apply to. The versions of the paper that follow are the versions that were submitted during the peer review process. They are not the versions of record or the final published versions. They should not be cited or distributed as the published version of this manuscript. BMJ Open is an open access journal and the full, final, typeset and author-corrected version of record of the manuscript is available on our site with no access controls, subscription charges or pay-per-view fees (http://bmjopen.bmj.com). If you have any questions on BMJ Open’s open peer review process please email [email protected] http://bmjopen.bmj.com/ on September 25, 2021 by guest. Protected copyright. BMJ Open BMJ Open: first published as 10.1136/bmjopen-2020-038909 on 28 December 2020. Downloaded from Which psychotherapy is effective in panic disorder? And which delivery formats are supported by the evidence? Study protocol for two systematic reviews and network meta-analyses. ForJournal: peerBMJ Open review only Manuscript ID bmjopen-2020-038909 Article Type: Protocol Date Submitted by the 30-Mar-2020 Author: Complete List of Authors: Papola, Davide; Università degli Studi di Verona, WHO Collaborating Centre for Research and Training in Mental Health and Service Evaluation; Department of Neuroscience, Biomedicine and Movement Sciences; Section of Psychiatry Ostuzzi, Giovanni; Università degli Studi di Verona, WHO Collaborating Centre for Research and Training in Mental Health and Service Evaluation; Department of Neuroscience, Biomedicine and Movement Sciences; Section of Psychiatry GASTALDON, CHIARA; Università degli Studi di Verona, WHO Collaborating Centre for Research and Training in Mental Health and Service Evaluation; Department of Neuroscience, Biomedicine and Movement Sciences; Section of Psychiatry http://bmjopen.bmj.com/ Purgato, Marianna; Universita degli Studi di Verona, WHO Collaborating Centre for Research and Training in Mental Health and Service Evaluation; Department of Neuroscience, Biomedicine and Movement Sciences Del Giovane, Cinzia; University of Bern, Institute of Primary Health Care (BIHAM) Pompoli, Alessandro; Psychiatric Rehabilitation Clinic Villa San Pietro Karyotaki, Eirini ; Vrije Universiteit Amsterdam, Department of Clinical, Neuro and Developmental Psychology, Amsterdam Public Health research on September 25, 2021 by guest. Protected copyright. institute Sijbrandij, Marit; Vrije Universiteit Amsterdam, Department of Clinical, Neuro and Developmental Psychology, Amsterdam Public Health research institute Furukawa, Toshi; Kyoto University, Departments of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine/School of Public Health Cuijpers, Pim; Vrije Universiteit Amsterdam, Department of Clinical, Neuro and Developmental Psychology, Amsterdam Public Health research institute Barbui, Corrado; University of Verona, WHO Collaborating Centre for Research and Training in Mental Health and Service Evaluation; Department of Neuroscience, Biomedicine and Movement Sciences Anxiety disorders < PSYCHIATRY, EPIDEMIOLOGY, Adult psychiatry < Keywords: PSYCHIATRY For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml Page 1 of 16 BMJ Open BMJ Open: first published as 10.1136/bmjopen-2020-038909 on 28 December 2020. 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Where the Submitting Author wishes to make the Work available on an Open Access basis (and 21 intends to pay the relevant APC), the terms of reuse of such Open Access shall be governed by a Creative 22 Commons licence – details of these licences and which Creative Commons licence will apply to this Work are set 23 out in our licence referred to above. 24 25 Other than as permitted in any relevant BMJ Author’s Self Archiving Policies, I confirm this Work has not been 26 accepted for publication elsewhere, is not being considered for publication elsewhere and does not duplicate 27 material already published. I confirm all authors consent to publication of this Work and authorise the granting 28 of this licence. 29 30 31 32 33 34 35 36 37 http://bmjopen.bmj.com/ 38 39 40 41 42 43 44 45 on September 25, 2021 by guest. Protected copyright. 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml Page 3 of 16 BMJ Open 1 2 3 BMJ Open: first published as 10.1136/bmjopen-2020-038909 on 28 December 2020. Downloaded from 4 5 6 Which psychotherapy is effective in panic disorder? And which delivery formats are 7 8 9 supported by the evidence? Study protocol for two systematic reviews and network meta- 10 11 analyses. 12 13 14 15 16 Davide Papola 1,§, Giovanni Ostuzzi1, Chiara Gastaldon1, Marianna Purgato1, Cinzia del Giovane2, Alessandro 17 18 Pompoli3, Eirini KaryotakiFor4, Marit Sijbrandij peer4, Toshi review A. Furukawa5, Pim only Cuijpers4, Corrado Barbui1. 19 20 21 22 1 WHO Collaborating Centre for Research and Training in Mental Health and Service Evaluation, Department 23 24 of Neuroscience, Biomedicine and Movement Science, Section of Psychiatry, University of Verona, Verona, 25 Italy; 26 27 2 28 Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland; 29 30 3 Psychiatric Rehabilitation Clinic Villa San Pietro, Trento, Italy; 31 32 4 Department of Clinical, Neuro and Developmental Psychology, Amsterdam Public Health research institute, 33 Vrije Universiteit Amsterdam, the Netherlands; 34 35 5 36 Departments of Health Promotion and Human Behavior, Kyoto University Graduate School of 37 Medicine/School of Public Health, Kyoto, Japan. http://bmjopen.bmj.com/ 38 39 40 41 42 43 § Corresponding author: 44 45 on September 25, 2021 by guest. Protected copyright. 46 Davide Papola, MD. WHO Collaborating Centre for Research and Training in Mental Health and 47 48 Service Evaluation Department of Neuroscience, Biomedicine and Movement Sciences; section of Psychiatry, 49 University of Verona. 50 51 52 Address: Policlinico Giambattista Rossi, Piazzale L.A. Scuro 10, 37134 Verona (Italy). 53 54 Tel. +39-045-8124063. 55 56 Email: [email protected] 57 58 59 60 Word count: 3379. 1 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml BMJ Open Page 4 of 16 1 2 3 BMJ Open: first published as 10.1136/bmjopen-2020-038909 on 28 December 2020. Downloaded from 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 For peer review only 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 http://bmjopen.bmj.com/ 38 39 40 41 42 43 44 45 on September 25, 2021 by guest. Protected copyright. 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 2 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml Page 5 of 16 BMJ Open 1 2 3 Abstract BMJ Open: first published as 10.1136/bmjopen-2020-038909 on 28 December 2020. Downloaded from 4 5 6 Introduction 7 8 Panic disorder is among the most prevalent anxiety diseases. It has been estimated that roughly 10% of people 9 10 11 around the world suffer from some degree of panic-related symptoms. Although psychotherapy is 12 13 recommended as first-line treatment for panic disorder, little is known about the relative efficacy of different 14 15 types of psychotherapies. Moreover, there is little evidence concerning the effectiveness of different formats 16 17 of major psychotherapeutic types, such as CBT. In this protocol, we present an overarching project consisting 18 For peer review only 19 of two systematic reviews and network meta-analyses to shed light on which psychotherapy and, specifically, 20 21 which cognitive behavioural therapy (CBT) delivery format should be considered most effective for panic 22 23 24 disorder with or without agoraphobia.
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