New Alternative to Chlorinated Solvents Fisher Chemical Ethyl Acetate Ethanol 3:1 Solution

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Due to increasing environmental and health concerns associated with the use of chlorinated solvents, Fisher Chemical has formulated an Optima™ grade solvent for use in flash and normal phase chromatography. Choose Fisher Chemical Ethyl Acetate Ethanol 3:1 Solution as a replacement for dichloromethane (methylene chloride). Studies 1, 2 have demonstrated that binary eluents of ethyl acetate and alcohols are suitable chromatography substitutes for methylene chloride/methanol binary eluents.

Pre-mixed solution for convenience Replace dichloromethane with and consistency comparable or better results • Eliminates the need to purchase and mix • Eliminate the interference caused by multiple solvents the chemical stabilizers required for • Saves time and money dichloromethane • Reduces weighing and mixing errors • Published reports demonstrate that a 3:1 • Each batch tested to ensure consistent blend of ethyl acetate and ethanol is a suitable composition and purity replacement for dichloromethane without compromising chromatographic separation1 Decreased environmental and human health risks Typical Applications Significantly reduces toxicity, environmental • Purification of organic compounds such as pharmaceutical intermediates via flash hazards, containment and disposal costs chromatography associated with chlorinated solvents. • Procedures involving polar molecules • Thin layer chromatography (TLC) and normal phase HPLC

Product Description Size Cat. No. 1L E151-1 Ethyl Acetate Ethanol 3:1 Solution, Optima grade, Amber Glass Bottle 4L E151-4

1 Taygerly, J. P.; Miller, L. M.; Yee, A.; Peterson, E. A., A convenient guide to help select replacement solvents for dichloromethane in chromatography. Green Chem. 2014, 14, (11), 3020-3025. 2 MacMillan, D.S.; Murry, J., et al, Replacement of dichloromethane with chromatographic purification: a guide to alternative solvents. Green Chem. 2012, 14, 3016.

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