CHM4670 – Bioinorganic Chemistry

UCC1: New Course Transmittal Form

Department Name and Number

Recommended SCNS Course Identi cation Pre x Level Course Number Lab Code Full Course Title Transcript Title (please limit to 21 characters)

Eective Term and Year Rotating Topic yes no

Amount of Credit Contact Hour: Base or Headcount S/U Only yes no

Repeatable Credit yes no If yes, total repeatable credit allowed

Variable Credit yes no If yes, minimum and maximum credits per semester

Course Description (50 words or less)

Prerequisites Co-requisites

Degree Type (mark all that apply) Baccalaureate Graduate Professional Other

Category of Instruction Introductory Intermediate Advanced

Rationale and place in curriculum

Department Contact Name Phone Email

College Contact Name Phone Email

Rev. 10/10 Comparison of CHM 6670 and proposed course CHM 3670

Classes will be held with a common lecture. Exams will be the same for both graduate and undergraduate students.

The course evaluation provides the main distinction between the graduate and undergraduate students.

CHM 3670 CHM 6670

Evaluation: Evaluation: Mid-term Exams (60%) Mid-Term Exams (40%) Final Exam/Research Paper (40%) Final Exam (35%) Research Paper (25%)

Rationale:

Undergraduate students can choose either to take the final exam or write a research paper as part of their evaluation. Graduate students are required to do both because critical reading and writing skills are essential to the training of graduate students. In addition, graduate students must demonstrate knowledge of the material and must be evaluated by all exams.

In contrast, undergraduate students, some of whom may be interested in pursuing advanced degrees in the chemical sciences, have the option of writing the research paper. This will require students becoming familiar with the research and researchers in a specific topic of their own choosing within bioinorganic chemistry. For those students interested in the material but uninterested in authoring a research paper, will be evaluated by a final exam. CHM 3670: Bioinorganic Chemistry Fall 2012 Location: TBA

Instructor: Prof. George Christou Email: [email protected] Office: CLB 408 Office Phone: 352-392-6737 Office Hours: XXX or by appointment

Course Description. The course will be an introduction to the structure and function of a variety of metalloproteins and metalloenzymes, concentrating on systems containing transition metals. Emphasis will be on the role of the metal ion(s) and the inorganic chemistry involved in the biomolecule’s function.

Course Objective. This course will fulfill an elective in the chemistry degree and biochemistry track of the chemistry degree and will introduce students to an active area of research with implications in medicine and renewable energy.

Course Objectives / Student Learning Outcomes Students will learn: • the essential role of metal ions in fundamental biological reactions • the data and type of information afforded by different physical methods, which are used to provide a complimentary picture of the chemistry of metal ions in biological systems • how synthetic chemistry contributes to understanding catalysis by metalloenzymes • to apply logical reasoning and critical thinking to interpret and synthesize scientific data

Required Text There is no required text. Handouts will be provided, supplemented by recommended reference texts and references to literature reviews and other sources.

Recommended Texts (freely available through the UF library website portal) 1. Special issue of Chemical Reviews, November 1996. 2. Special issue of Chemical Reviews, February 2004. 3. “Bioinorganic Chemistry: Inorganic Elements in the Chemistry of Life”, W. Kaim and B. Schwederski, Wiley: Chichester, England; 2001. 4. “Biological Inorganic Chemistry”, I. Bertini, H. B. Gray, E. I. Stiefel, J. S. Valentine; University Science Books: Mill Valley CA, 2006. 5. “Biochemistry”, L. Stryker; Freeman: New York.

Grades Grades will be based on two short exams during the semester (total 60%) and either a research paper or the final exam (either will be 40%). For information on UF's Grading Policy, see: http://www.registrar.ufl.edu/catalog/policies/regulationgrades.html http://www.isis.ufl.edu/minusgrades.html

Course grades will be assigned on a curve with the following percentages used for guidance:

100-90% A 89-83% B+ 82-78 % B 77-72% C+ 71-64% C 63-58% D+ 57-50% D 49-00% E

Research Paper If a student chooses to do the research paper, the chosen topic will be discussed with the teacher and the topic will be one that was not covered in the course. A list of suitable topics, including medical applications of inorganic compounds, will be made available by the instructor within the first six (6) weeks of the semester. Topics not on the list may also be chosen, with approval from the instructor. Students choosing to write a research paper in lieu of taking the final exam must notify the instructor within the first six (6) weeks of the semester.

Exams Exams cover all lectures and reading assignments. It is the student’s responsibility to ask questions (either during class or at office hours) if they do not understand lecture or reading materials. The final exam covers the entire semester, but will focus on material after the mid-term exam. Exams will be administered in class. Make-up exams will only be given by pre-arrangement (before the exam) or under extraordinary circumstances (e.g., medical emergencies) that must be documented.

Attendance and Absence Policy Attendance is expected although not used as part of student assessment. Whenever possible, the instructor should be notified prior to the absence. When this is not possible, the instructor should be notified as soon as possible. In general, acceptable reasons for absence from class include illness, serious family emergencies, special curricular requirements (e.g., judging trips, field trips, professional conferences), military obligation, severe weather conditions, religious holidays and participation in official university activities such as music performances, athletic competition or debate. Absences from class for court-imposed legal obligations (e.g., jury duty or subpoena) must be excused. Further information can be found in the undergraduate catalog (https://catalog.ufl.edu/ugrad/current/regulations/).

Academic Honesty Students are required to be honest in their coursework, may not use notes during quizzes or exams, and must properly cite all sources that they have consulted for their projects. Any act of academic dishonesty will be reported to the Dean of Students, and may result in failure of the assignment in question and/or the course. For University of Florida’s honor code, see http://www.dso.ufl.edu/sccr/honorcodes/honorcode.php.

Accommodations for Students with Disabilities Students requesting classroom accommodation must first register with the Dean of Students Office. The Dean of Students Office will provide documentation to the student who must then provide this documentation to the Instructor when requesting accommodation. Contact the Disability Resources Center (http://www.dso.ufl.edu/drc/) for information about available resources for students with disabilities.

Counseling and Mental Health Resources Students facing difficulties completing the course or who are in need of counseling or urgent help should call the on-campus Counseling and Wellness Center (352-392-1575; http://www.counseling.ufl.edu/cwc/). Course Outline

I. Metallobiomolecules: General a) Metal-binding organic groups e) Metal substitution b) Metal structural types f) Synthetic analogues c) Elements of protein structure g) Mossbauer spectroscopy d) The entatic state hypothesis

II. Metallobiomolecules: Specific A detailed look at representative examples—as many as time will permit—and their synthetic analogues, where available. 1. Proteins: Oxygen carriers: hemoglobin/myoglobin, hemerythrin, hemocyanin Electron transfer: iron-sulfur proteins, blue copper proteins Metal transport/storage: ferritin, transferrin, metallothioneins 2. Enzymes: Hydrolases: carboxypeptidase, carbonic anhydrase Carbon metabolism: methane monooxygenase, cytochrome P-450 enzymes Oxygen metabolism: oxidases, oxygenases, superoxide dismutase, catalase Nitrogen fixation: nitrogenase Dioxygen production: water-oxidizing complex of photosynthesis

CHM 6670: Inorganic Biochemistry Fall 2010 Location: CLB 212

Instructor: Prof. George Christou Email: [email protected] Office: CLB 408 Office Phone: 352-392-6737 Office Hours: W, 2:00-4:00 pm, and by appointment

Required Text There is no required text. Handouts will be provided, supplemented by recommended reference texts and references to literature reviews and other sources.

Grades Grades will be based on the research paper (25%), two short exams during the semester (total 40%), and a final exam (35%). For information on UF's Grading Policy, see: http://www.registrar.ufl.edu/catalog/policies/regulationgrades.html http://www.isis.ufl.edu/minusgrades.html

Course grades will be assigned on a curve with the following percentages used for guidance:

100-93% A 92-88% B+ 87-83% B 82-78% C+ 77-73% C 72-68% D+ 67-63% D 62-00% E

Research Paper A research paper will be required from every student on a topic not covered in the course. A list of suitable topics, including medical applications of inorganic compounds, will be made available by the instructor within the first six (6) weeks of the semester. Topics not on the list may also be chosen, with approval from the instructor.

Exams Exams cover all lectures and reading assignments. It is the student’s responsibility to ask questions (either during class or at office hours) if they do not understand lecture or reading materials. The final exam covers the entire semester, but will focus on material after the mid-term exam. Exams will be administered in class. Make-up exams will only be given by pre-arrangement (before the exam) or under extraordinary circumstances (see attendance and absence policy) that must be documented.

I. Metallobiomolecules: General

a) Metal-binding organic groups e) Metal substitution b) Metal structural types f) Synthetic analogues c) Elements of protein structure g) Mossbauer spectroscopy d) The entatic state hypothesis

II. Metallobiomolecules: Specific

Detailed look at representative examples—as many as time will permit—and their synthetic analogues, where available.

1. Proteins: Oxygen carriers: hemoglobin/myoglobin, hemerythrin, hemocyanin Electron transfer: iron-sulfur proteins, blue copper proteins Metal transport/storage: ferritin, transferrin, metallothioneins

2. Enzymes: Hydrolases: carboxypeptidase, carbonic anhydrase Carbon metabolism: methane monooxygenase, cytochrome P-450 enzymes Oxygen metabolism: oxidases, oxygenases, superoxide dismutase, catalase Nitrogen fixation: nitrogenase Dioxygen production: water-oxidizing complex of photosynthesis