Anti-Nucleobindin-2 Monoclonal Antibody, Clone 22C4.2 (CABT-B1153) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

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Anti-Nucleobindin-2 monoclonal antibody, clone 22C4.2 (CABT-B1153) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Specificity Detects nucleobindin-2, but not nesfatin-1. Reactivity toward nesfatin-2 or nesfatin-3 has not been determined. Immunogen GST-tagged recombinant protein corresponding to human Nucleobindin-2. Isotype IgG1, κ Source/Host Mouse Species Reactivity Human, Mouse, Rat Clone 22C4.2 Purification Protein G Purified Conjugate Unconjugated Applications WB, IHC-P Molecular Weight ~ 50 kDa observed Format Liquid Concentration Please refer to lot specific datasheet. Size 100 μg Buffer 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Preservative 0.05% Sodium Azide Storage Stable for 1 year at 2-8°C from date of receipt. BACKGROUND Introduction Nucleobindin-2 (UniProt P80303; also known as DNA-binding protein NEFA, Epididymis secretory protein Li 109, Gastric cancer antigen Zg4, Nucleobinding 2, Prepronefastin, Prepronesfatin) is encoded by the NUCB2 gene (also known as HEL-S-109, NEFA) (Gene ID 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved 4925) in human. Nucleobindin-2 is initially translated as a 420 aa precursor protein. Cleavage of signal peptide (aa1-24) yields the 396 aa mature nucleobindin-2 with very high sequence homology among human, mouse, and rat species (> 85%). Post-translational processing by prohormone convertases (PC 1/3 and PC 2) cleaves nucleobindin-2 into nesfatin-1, nesfatin-2, and nesfatin-3 (aa1–82, aa85–163, and aa166–396, respectively, numbering based on mature sequence). Nesfatin-1 is a well recognized circulating anorexigenic peptide, whose production increases post-prandially. Nucleobinin-2 contains two calcium-binding EF-hand domains separated by an acidic amino acid-rich region, and a leucine zipper. NUCB2 is expressed in key hypothalamic nuclei and plays a role in energy homeostasis. It is also expressed in various human peripheral tissues, including the stomach, pancreas, reproductive organs, and adipose tissue, suggesting its roles in various metabolic functions. NUCB2 expression level is reported to be elevated in clear cell renal cell carcinoma (ccRCC), breast cancer, and prostate cancer (PCa) tissues. GENE INFORMATION Entrez Gene ID 4925 UniProt ID P80303 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.

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