Planck Presenting Einstein with the First Planck Gold Medal in 1929
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Paul Ehrlich
Paul Ehrlich Paul Ehrlich (geboren am 14. März 1854 in Strehlen, Regierungsbezirk Breslau, Provinz Schlesien; gestorben am 20. August 1915 in Bad Homburg vor der Höhe[1]) war ein deutscher Mediziner und Forscher. Durch seine Färbemethoden unterschied er verschiedene Arten von Blutzellen, wodurch die Diagnose zahlreicher Blutkrankheiten ermöglicht wurde. Mit seiner Entwicklung einer medikamentösen Behandlung der Syphilis begründete er die moderne Chemotherapie. Außerdem war er entscheidend an der Entwicklung des Heilserums gegen Diphtherie beteiligt, die üblicherweise Emil von Behring alleine zugeschrieben wird. Als Direktor des Instituts für experimentelle Therapie arbeitete er die Methoden für die Standardisierung („Wertbemessung“[2] bzw. Wertbestimmung) von Sera aus. 1908 erhielt er zusammen mit Ilja Metschnikow für seine auf dem Gebiet der Serumsforschung entwickelten Beiträge zur Immunologie den Nobelpreis für Physiologie oder Medizin. Paul Ehrlich (1915) Inhaltsverzeichnis Leben Herkunft Schule und Studium Berlin Frankfurt Werk Färbemethoden für die Hämatologie Serumforschung Freundschaft mit Robert Koch Erste Arbeiten zur Immunität Arbeit mit Behring an einem Diphtherieheilserum Die Wertbestimmung von Sera Die Seitenkettentheorie Krebsforschung Chemotherapie Die Vitalfärbung Methylenblau Die Suche nach einer „Chemotherapia specifica“ Nachwirkungen Spielfilm Briefmarken und Banknote Ehrlich als Namensgeber Ausstellungen Literatur Weblinks Einzelnachweise Leben Herkunft Paul Ehrlich wurde als zweites Kind jüdischer Eltern geboren. -
Warburg Effect(S)—A Biographical Sketch of Otto Warburg and His Impacts on Tumor Metabolism Angela M
Otto Cancer & Metabolism (2016) 4:5 DOI 10.1186/s40170-016-0145-9 REVIEW Open Access Warburg effect(s)—a biographical sketch of Otto Warburg and his impacts on tumor metabolism Angela M. Otto Abstract Virtually everyone working in cancer research is familiar with the “Warburg effect”, i.e., anaerobic glycolysis in the presence of oxygen in tumor cells. However, few people nowadays are aware of what lead Otto Warburg to the discovery of this observation and how his other scientific contributions are seminal to our present knowledge of metabolic and energetic processes in cells. Since science is a human endeavor, and a scientist is imbedded in a network of social and academic contacts, it is worth taking a glimpse into the biography of Otto Warburg to illustrate some of these influences and the historical landmarks in his life. His creative and innovative thinking and his experimental virtuosity set the framework for his scientific achievements, which were pioneering not only for cancer research. Here, I shall allude to the prestigious family background in imperial Germany; his relationships to Einstein, Meyerhof, Krebs, and other Nobel and notable scientists; his innovative technical developments and their applications in the advancement of biomedical sciences, including the manometer, tissue slicing, and cell cultivation. The latter were experimental prerequisites for the first metabolic measurements with tumor cells in the 1920s. In the 1930s–1940s, he improved spectrophotometry for chemical analysis and developed the optical tests for measuring activities of glycolytic enzymes. Warburg’s reputation brought him invitations to the USA and contacts with the Rockefeller Foundation; he received the Nobel Prize in 1931. -
Purges in Comparative Perspective: Rules for Exclusion and Inclusion in the Scientific Communityunder Political Pressure
Purges in Comparative Perspective: Rules for Exclusion and Inclusion in the Scientific Communityunder Political Pressure Richard Beyler,Alexei Kojevnikov,and Jessica Wang* ABSTRACT During the intense political upheavalthat dominatedthe middle decades of the twentiethcentury, modem states intensifiedtheir drives to disciplinebroad sectors of society and ensuretheir political reliability.Subjected to such pressures,scien- tific institutionsfaced the challenge of admittingnew, officially mandatedcriteria into the regulationof scientificlife. We examinethe effects of these policies on the KaiserWilhelm Society in NationalSocialist Germany,the Max PlanckSociety in occupied Germanyafter 1945, the USSR Academy of Sciences throughoutthe Stalinera, and the NationalAcademy of Sciences in early cold warAmerica. In all these cases, while academicelites largelyaccepted the requiredradical changes in the rules for membershipin the scientificcommunity, they also soughtto manipu- late the processto theirown institutionaladvantage. INTRODUCTION The relationship between state power and professional autonomy has long constituted a major theme in the history of science. Throughout the eras of turmoil that defined their respective nations' politics from the 1930s through the 1950s, the states in Ger- many, the Soviet Union, and the United States became obsessively, at times para- noically, preoccupied with defining and adjudicating their citizens' political, ethnic, or moral acceptability. These concerns frequently resulted in purges from scientific institutions of persons deemed undesirable: "non-Aryans," communists, and social- ists in National Socialist Germany; "bourgeois experts" and "cosmopolites" in Stal- inist Russia; "communist sympathizers" and "subversives" in cold war America. Purges of this kind have often been understood as morality plays, with an under- standable emphasis on the victimization of the innocent by the repressive state. In what follows, we attempt to broaden the discussion by going beyond the phenomenon of purges as such. -
Der Pathologe
Band 36 · Sonderausgabe · November 2015 Der Pathologe Organ der Deutschen Abteilung der Internationalen Akademie für Pathologie, der Deutschen, der Österreichischen und der Schweizerischen Gesellschaft für Pathologie und des Bundesverbandes Deutscher Pathologen 99. Jahrestagung der Deutschen Gesellschaft für Pathologie e. V. Frankfurt am Main, 28. – 31. Mai 2015 Indexed in Science Citation Index Expanded and Medline Verhandlungen der Deutschen Gesellschaft für Pathologie e.V. www.DerPathologe.de www.springermedizin.de Der Pathologe Verhandlungen 2015 der Deutschen Gesellschaft für Pathologie e.V. Rudolf-Virchow-Preis Ausschreibung 2016 Der Preis wird laut Satzung der Rudolf-Virchow-Stiftung für Pathologie und der Deutschen Gesellschaft für Pathologie e.V. einem Pathologen unter Jahren für eine noch nicht ver öffentlichte oder eine nicht länger als ein Jahr vor der Bewerbung publizierte wissenschaftliche Arbeit verliehen. Die Verleihung des Preises erfolgt auf der . Jahrestagung der Deutschen Gesellschaft für Pathologie e.V. Zusammen mit einem Lebenslauf und einer Publikationsliste reichen Bewerber ihre Arbeit ein (bitte alle Unterlagen in doppelter Ausfertigung sowie elektronisch einreichen). Abgabetermin: bis . Dezember Einzureichen bei: Prof. Dr. med. Holger Moch Geschäftsführendes Vorstandsmitglied der Deutschen Gesellschaft für Pathologie e.V. UniversitätsSpital Zürich Institut für Klinische Pathologie Schmelzbergstrasse CH – Zürich [email protected] Die Satzung der Rudolf-Virchow-Stiftung für Pathologie sowie weitere Informationen -
René Dubos, Tuberculosis, and the “Ecological Facets of Virulence”
HPLS (2017) 39:15 DOI 10.1007/s40656-017-0142-5 ORIGINAL PAPER René Dubos, tuberculosis, and the “ecological facets of virulence” Mark Honigsbaum1 Received: 15 January 2017 / Accepted: 23 June 2017 / Published online: 4 July 2017 © The Author(s) 2017. This article is an open access publication Abstract Reflecting on his scientific career toward the end of his life, the French- educated medical researcher Rene´ Dubos presented his flowering as an ecological thinker as a story of linear progression—the inevitable product of the intellectual seeds planted in his youth. But how much store should we set by Dubos’s account of his ecological journey? Resisting retrospective biographical readings, this paper seeks to relate the development of Dubos’s ecological ideas to his experimental practices and his career as a laboratory researcher. In particular, I focus on Dubos’s studies of tuberculosis at the Rockefeller Institute in the period 1944–1956—studies which began with an inquiry into the tubercle bacillus and the physiochemical determinants of virulence, but which soon encompassed a wider investigation of the influence of environmental forces and host–parasite interactions on susceptibility and resistance to infection in animal models. At the same time, through a close reading of Dubos’s scientific papers and correspondence, I show how he both drew on and distinguished his ecological ideas from those of other medical researchers such as Theobald Smith, Frank Macfarlane Burnet, and Frank Fenner. However, whereas Burnet and Fenner tended to view ecological interactions at the level of populations, Dubos focused on the interface of hosts and parasites in the physio- logical environments of individuals. -
The Miracle of the Mould Howard Florey and Colleagues Overcame Great Obstacles to Isolate Penicillin
books and arts The miracle of the mould Howard Florey and colleagues overcame great obstacles to isolate penicillin. The Mould in Dr Florey’s Coat: The Remarkable True Story of the Penicillin Miracle by Eric Lax Little, Brown: 2004. 288 pp. £16.99 William Shaw HAAS/BETTMANN/CORBIS D. Well-researched and readable accounts of medical science and disease are always wel- come. The first thing to note about this new work by Eric Lax, whose earlier efforts have been a well-regarded biography of Woody Allen and an engaging account of cancer chemotherapy, is that its title prom- ises a great deal — and does so rather late in the day. There is little doubt that, after more than half a century of personal reflections and scholarship, the story of the emergence of penicillin as a life-saving medicine remains remarkable — not least for the obstacles overcome and for the personalities of the trio of Nobel laureates involved: Alexander Fleming, Howard Florey and Ernst Chain. But promise of a true story begs the question of what has been on offer since 1945. And was there a miracle? Well, nearly, at least in the sense that the small team assembled by Florey at the Sir William Dunn School of Norman Heatley (below left) oversaw the mass production of penicillin in 1940s America. Pathology in Oxford, UK, in the dark and difficult early honorary doctorate of medi- from farther afield, such as the Yale papers years of the Second World cine, the first non-medical of John Fulton, Florey’s close friend and War, hardly seemed like a person to be so honoured. -
The Making of a Biochemist
book reviews disappearance of kuru as an important In the late 1920s, he looked into the effect TION episode in our understanding of the risks of light on the inhibition by carbon monox- A associated with this type of infectious ide of respiration in living cells. This work process. Informing the wider community of encompassed considerations of photo- these risks may lead to a more helpful debate chemical processes in terms of quantum about the public health policies required chemistry, and the use of the manometer, NOBEL FOUND to minimize the chances of another BSE photoelectric cell and spectroscope. From epidemic. Books such as this are useful in the shape of the curve obtained by plotting this context. the effectiveness of light against its wave- Colin L. Masters is in the Department of Pathology, length, it was possible to deduce the resem- 8 The University of Melbourne, Parkville, Victoria, blance between the respiratory ferment and 3052, Australia. haemins. Warburg was awarded the Nobel prize for physiology or medicine in 1931 for his recognition of the haemin-type nature of the respiratory ferment and its underlying The making principles. The development of Warburg’s theoreti- of a biochemist cal thinking and experimental procedures are Otto Warburgs Beitrag zur ably chronicled in Petra Werner’s introducto- Atmungstheorie: Das Problem der ry essay. Her book is the first volume of an Sauerstoffaktivierung* edition of Warburg’s correspondence Brilliant but flawed: Warburg tended to pettiness. by Petra Werner deposited in the Berlin–Brandenburg Aca- Basilisken-Presse: 1996. Pp. 390. DM136 demy of Sciences. Regrettably, the 143 pub- 1950). -
Glycolysis and Gluconeogenesis
CC7_Unit 2.3 Glycolysis and Gluconeogenesis Glucose occupies a central position in the metabolism of plants, animals and many microorganisms. In animals, glucose has four major fates as shown in figure 1. The organisms that do not have access to glucose from other sources must make it. Plants make glucose by photosynthesis. Non-photosynthetic cells make glucose from 3 and 4 carbon precursors by the process of gluconeogenesis. Glycolysis is the process of enzymatic break down of one molecule of glucose (6 carbon) into two pyruvate molecules (3 carbon) with the concomitant net production of two molecules of ATP. The complete glycolytic pathway was elucidated by 1940, largely through the pioneering cotributions of Gustav Embden, Otto Meyerhof, Carl Neuberg, Jcob Parnad, Otto Wrburg, Gerty Cori and Carl Cori. Glycolysis is also known as Embden-Meyerhof pathway. • Glycolysis is an almost universal central pathway of glucose catabolism. • Glycolysis is anaerobic process. During glycolysis some of the free energy is released and conserved in the form of ATP and NADH. • Anaerobic microorganisms are entirely dependent on glycolysis. • In most of the organisms, the pyruvate formed by glycolysis is further metabolised via one of the three catabolic routes. 1) Under aerobic conditions, glucose is oxidized all the way to C02 and H2O. 2) Under anaerobic conditions, the pyruvic acid can be fermented to lactic acid or to 3) ethanol plus CO2 as shown in figure 2. • Glycolytic breakdown of glucose is the sole source of metabolic energy in some mammalian tissues and cells (RBCs, Brain, Renal medulla and Sperm cell). Glycolysis occurs in TEN steps. -
DAVID NACHMANSOHN March 17, 1899-November 2, 1983
NATIONAL ACADEMY OF SCIENCES D A V I D N ACHMANSOHN 1899—1983 A Biographical Memoir by SEVERO OCHOA Any opinions expressed in this memoir are those of the author(s) and do not necessarily reflect the views of the National Academy of Sciences. Biographical Memoir COPYRIGHT 1989 NATIONAL ACADEMY OF SCIENCES WASHINGTON D.C. DAVID NACHMANSOHN March 17, 1899-November 2, 1983 BY SEVERO OCHOA AVID NACHMANSOHN'S scientific life path was strongly D influenced by his early studies on the biochemistry of muscle in Otto Meyerhof's laboratory. This experience led to an interest in the biochemistry of nerve activity, a field of study to which he would devote most of his scientific life. In so doing, he contributed—perhaps more than any other in- vestigator—to our understanding of the molecular basis of bioelectricity. David Nachmansohn was born in Jekaterinoslav, Russia (now Dnjetropetrowsk, USSR). His parents came from middle-class families among whom were many lawyers, phy- sicians, and other professionals. Before David and his two sisters reached school age, the family moved to Berlin where they had many relatives. Thus, David's background and edu- cation were essentially, if not exclusively, German. His college education was strongly humanistic, with Latin, Greek, liter- ature, and history as mainstays, some mathematics, and the rudiments of physics. Through his readings, perhaps pri- marily through his reading of the second part of Goethe's Faust when he was only seventeen years of age, he became interested in philosophy—so much so that he continued to attend courses and seminars in philosophy even while a med- ical student at Heidelberg in 1920. -
Speaker's Manuscript
Nobel Prize Lessons 2018 Speaker’s manuscript – the 2018 Medicine Prize The Nobel Prize in Physiology or Medicine • The Nobel Prize in Physiology or Medicine is one of the five prizes founded by Alfred Nobel and awarded on December 10 every year. Before Alfred Nobel died on December 10, 1896, he wrote in his will that the largest part of his fortune should be placed in a fund. The yearly interest on this fund would pay for a prize given to “those who, during the preceding year, shall have conferred the greatest benefit to humankind.” Who is rewarded with the Medicine Prize? • The Nobel Prize in Physiology or Medicine is thus awarded to people who have either made a discovery about how organisms work or have helped find a cure for a disease. • This is May-Britt Moser, 2014 Nobel Laureate in Medicine. In 2005 she and Edvard Moser discovered a type of cell in the brain that is important for determining one's position. They also found that those cells cooperate with different nerve cells in the brain that help us to navigate. You can say that the Laureates discovered and explained a kind of GPS system in the brain. • Other Medicine Laureates include: • Francis Crick, James Watson and Maurice Wilkins, who received the 1962 Prize for their discoveries and descriptions about the structure of DNA molecules. • Alexander Fleming, Ernst Chain and Howard Florey, who received the 1945 Prize for the discovery of penicillin and its curative effects on bacterial diseases. Medicine Prize 2018 • The 2018 Nobel Prize is about a new way of treating cancer. -
The Prime Cause, Prevention and Treatment of Cancer
International Science and Investigation Journal ISSN: 2251-8576 2016, 5(5) Journal homepage: www.isijournal.info The Prime Cause, Prevention and Treatment of Cancer Somayeh Zaminpira *1, Sorush Niknamian 2 *1 Ph.D. in Cellular and Molecular Biology, University of Cambridge, United Kingdom 2 Ph.D. in Cellular and Molecular Biology, University of Cambridge, United Kingdom 102 International Science and Investigation Journal Vol. 5(5) Abstract This meta-analysis research has gone through more than 200 studies from 1934 to 2016 to find the differences and similarities in cancer cells, mostly the cause. The most important difference between normal cells and cancer cells is how they respire. Normal cells use the sophisticated process of respiration to efficiently turn any kind of nutrient that is fat, carbohydrate or protein into high amounts of energy in the form of ATP. This process requires oxygen and breaks food down completely into harmless carbon dioxide and water. Cancer cells use a primitive process of fermentation to inefficiently turn either glucose from carbohydrates or the amino acid glutamine from protein into small quantities of energy in the form of ATP. This process does not require oxygen, and only partially breaks down food molecules into lactic acid and ammonia, which are toxic waste products. The most important result is that fatty acids or better told fats cannot be fermented by cells. This research mentions the role of ROS and inflammation in causing mitochondrial damage and answers the most important questions behind cancer cause and mentions some beneficial methods in preventing and treatment of cancer. Keywords Cancer, Respiration, Fermentation, ROS, Prevention Introduction 1. -
Die Frankfurter Universitätsmedizin Zwischen 1933 Und 1945
Udo Benzenhöfer Die Frankfurter Universitätsmedizin zwischen 1933 und 1945 Klemm + Oelschläger Münster/Ulm 2012 Bibliografische Information der Deutschen Nationalbibliothek. Die Deutsche Nationalbibliothek verzeichnet diese Publikation in der Deutschen Nationalbibliografie; detaillierte bibliografische Daten sind im Internet über http://dnb.d-nb.de abrufbar. 1. Auflage, 2012 Copyright beim Autor und beim Verlag Klemm + Oelschläger Alle Rechte vorbehalten! Umschlaggestaltung und Satz: Ralph Gabriel, Wien Druck und Bindung: CPI buchbücher.de, Birkach ISBN 978-3-86281-050-5 Inhalt Danksagung . 7 1. Einleitung . 9 2. Die Universitätsmedizin von 1933 bis zum Kriegsbeginn . 11 2.1. Allgemeines . 11 2.2. Entrechtungen . 17 2.3. Berufungen . 40 2.4. Kliniken und Institute . 57 3. Die Universitätsmedizin im Krieg . 65 3.1. Allgemeines . 65 3.2. Berufungen . 68 3.3. Kliniken und Institute . 74 4. Schandtaten und Verbrechen . 81 5. Opposition . 93 6. Quellen und Literatur . 97 Danksagung Mein Dank für Hilfen und Hinweise gebührt Monika Birkenfeld, M. A., Christa Eid, Christina Lorenz, M. A., und Dr. Katja Weiske vom Sen- ckenbergischen Institut für Geschichte und Ethik der Medizin in Frankfurt. Äußerst hilfreich für die Erstellung der Studie waren auch durch Werkverträge aus Institutsmitteln finanzierte Vorarbeiten von Dr. phil. Gisela Hack-Molitor (zu den Kliniks- und Institutsleitern von 1938 bis 1952 auf der Grundlage der Vorlesungsverzeichnisse) und von PD Dr. Ralf Forsbach (zum Fakultätsalbum). Prof. Dr. Dr. Udo Benzenhöfer Oktober 2012 7 1. Einleitung Das Buch ist in vier größere Teile aufgeteilt: Zunächst werden die wich- tigsten Entwicklungen in der Frankfurter Universitätsmedizin bis zum Kriegsbeginn verfolgt (Allgemeines, Entrechtungen, Berufungen, Kli- niken und Institute). Anschließend wird die Universitätsmedizin im Krieg beschrieben (Allgemeines, Berufungen, Kliniken und Institute).