US 20110268678A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2011/0268678 A1 Armstrong (43) Pub. Date: Nov. 3, 2011

(54) VITAMIND FORMING SUNSCREEN A6IP35/00 (2006.01) A6IP3 L/16 (2006.01) (76) Inventor: Ernest T. Armstrong, Palm Desert, A6IP3/10 (2006.01) CA (US) A6IP3/04 (2006.01) A6IP 9/04 (2006.01) (21) Appl. No.: 13/143,180 A6IP 9/12 (2006.01) A6IP 9/10 (2006.01) A6IP 25/28 (2006.01) (86). PCT No.: PCT/B2009/055881 A61O 1704 (2006.01) A6IR 8/35 (2006.01) S371 (c)(1), A6IR 8/31 (2006.01) (2), (4) Date: Jul. 1, 2011 A6IR 8/37 (2006.01) Related U.S. Application Data A61K 8/46 (2006.01) (60) Provisional application No. 61/204,146, filed on Jan. (52) U.S. Cl...... 424/60; 424/59 5, 2009. (57) ABSTRACT Publication Classification A composition Suitable for providing protection against ultra (51) Int. Cl. violet radiation containing one or more active ultraviolet A6 IK 8/4I (2006.01) radiation absorber through which ultraviolet radiation in A6IP 9/00 (2006.01) approximately the 295 to 315 nanometer range is permitted to A6IP 9/10 (2006.01) enter the skin in an amount sufficient for the body to produce A6IP 9/08 (2006.01) a healthful and disease-opposing quantity of vitamin D and A6IP3/04 (2006.01) chemical precursors thereof. The composition is particularly A6IP3L/2 (2006.01) used in Sunscreens promoting on the one hand vitamin D. A6IP37/00 (2006.01) production, on the other hand protecting the skin against A6IP 29/00 (2006.01) harmful ultraviolet radiation. US 2011/0268678 A1 Nov. 3, 2011

VITAMIND FORMING SUNSCREEN terrestrial vertebrates, including humans, obtain most of their Vitamin D requirement from casual exposure to Sunlight. CROSS REFERENCE TO RELATED Application of a Sunscreen, increased skin pigmentation, APPLICATION aging, hair and clothing all reduce vitamin D production in the skin. 0001. This application claims the priority right from the 0009 Vitamin D is made in the body when a derivative of U.S. provisional patent application 61/204,146 that was filed cholesterol called 7-dehydrocholesterol is converted to pre on Jan.5, 2009, the content of which is herewith incorporated Vitamin D3 using the energy from radiation that has entered in its entirety by reference. Also, this application is a national the skin. Pre-vitamin D3 then spontaneously changes itself phase entry under 35 U.S.C. S371 based on PCT/IB2009/ into its isomer, vitamin D3. Vitamin D3 is then changed to 055881 filed on Dec. 21, 2009. 25-hydoxyvitamin D3 which circulates in the blood serum or is stored in the liver until needed. 25-hydroxyvitamin D3 is BACKGROUND OF THE INVENTION later changed in the kidneys or elsewhere into 1,25-dihydrox 0002 One aspect of the invention is directed to sunscreen yvitamin D3, the main biologically active form. formulations that protect the skin against the damaging 0010. Following are synonyms: pre-vitamin D3 is chole effects of sunlight while providing the health benefits of calciferol; 25-hydoxyvitamin D3 is 25(OH)D3 or calcidiol; increased vitamin D production by the body is disclosed. 1,25-dihydroxyvitamin D3 is 1,25(OH)2D3 or calcitriol. in Another aspect is directed to methods for applying Sun this patent vitamin D stands for vitamin D3, and is sometimes SCCS. used in a general sense. 0003. One example embodiment of the current invention 0011. The amount of sunscreen (or sunblock) applied to is a Sunscreen formulation with active ingredients that screen the skin can influence how much of the incoming UV radia as much of the damaging, cancer-causing ultraviolet radiation tion is absorbed, with a thicker layer generally absorbing as possible while at the same time permitting passage of light more radiation. The current invention eliminates certain in the wavelengths used by the body to synthesize vitamin D active ingredients which are known to be sticky or oily, espe and for tanning. cially in higher concentrations. One advantage of the current 0004 Sunscreens are widely known and used to prevent invention over traditional Sunscreen concoctions is, Surpris the harmful affects of sun exposure. Each different active ingly, overall better skin protection because the behavior of ingredient used in Sunscreens has a unique profile in regard to Sunscreen users is such that they tend to use larger quantities which wavelengths of ultraviolet (UV) radiation it can absorb and tend to re-apply more frequently when the ingredients are and what percentage of those wavelengths it can absorb. not as sticky or oily. Traditionally sunscreen formulators, in their zeal to protect 0012. The action spectrum of epidermal vitamin D photo people who are exposed to Sunlight from skin cancer and synthesis can be graphed in an absorbance curve showing that wrinkles, have combine complimentary active ingredients to the peak absorbance for vitamin D synthesis is at about 297 filter UV radiation in a spectral overlap that screens the broad nm, with large amounts produced between 295 and 305 nm, est spectrum of radiation possible. This broad spectrum and lesser amounts produced farther from the peak of the approach, unfortunately, also blocks the beneficial wave curve between 290 and 295 nm and between 305 and 315 nm. lengths of radiation in approximately the 295 to 315 nanom (Wavelengths between 270 and 290 nm will cause vitamin D eter range which are needed for vitamin D synthesis in the synthesis, but are for the most part filtered by the atmosphere, skin. and therefore generally do not reach the body.) As the wave 0005. There is broad agreement by vitamin D researchers lengths increase from 290 to 315 nm, so does the relative that getting quantities of vitamin D that are sufficient for intensity of UVB radiation reaching the earth's surface. optimum health from diet alone is difficult, that vitamin D is Therefore as a practical matter, it has been discovered that produced in Sufficient quantities when a sensible amount of although the absorbance by Vitamin D precursors is highest in Sunlight at lower latitudes penetrates the skin and that a large the 295 to 300 nm range, there is at the surface of the earth a percentage of the population would benefit from higher levels higher intensity of UVB radiation available to the skin of vitamin D. between 300 and 305 nm than is available between 295 to 300 0006 Vitamin D plays an essential role in the prevention of bone problems (of which one in twelve people living in 0013 An important consideration of the current invention higher latitudes is at risk), prevention of Some sixteen com is that although the range of radiation that is filtered by the mon cancers (which together are responsible for 30 times current invention's appropriate UV filter(s) may overlap part more deaths than skin cancer) and modulation of neuromus ofall of the absorption range needed for vitamin D production cular and immune function. Research also indicates that Suf (i.e. approximately 295 to 315 nm), the active ingredient(s) of ficient levels of vitamin D may prevent or reduce the inci the current invention permit the passage of Sufficient quantity dence of inflammation, multiple Sclerosis, rheumatoid and quality of radiation for the body to effectively produce arthritis, hypertension, lupus, cardiovascular disease, type 1 Vitamin D. The current invention discloses a Surprising diabetes and type 2 diabetes. Obesity is associated with lower improvement in Sunscreen formulation that teaches away circulating vitamin D levels. from mainstream full-spectrum screening approach. 0007 Disclosed are significant, untapped health benefits 0014 Organic molecules known as UV filters (i.e. the and considerable commercial potential by the current inven active ingredients in Sunscreens) have multiple atoms which tion. can vibrate and rotate in relation to each other. Many closely 0008 Vitamin D is a fat-soluble vitamin that is naturally spaced energy transitions mean that instead of absorbing present in very few foods, added to others, available as a exact frequencies of radiation, molecules absorb groups of dietary supplement and produced when ultraviolet (UV) rays frequencies of radiation. The many closely spaced absorption from Sunlight (or tanning beds) enter the skin. Essentially all lines combine to make an absorption band. Sunscreens made US 2011/0268678 A1 Nov. 3, 2011

from organic molecules absorb different percentages of the from AVobenzone or Ecamsule and one or more active ingre radiation. These percentages of absorption can be graphed as dient that filters ultraviolet radiation in approximately the 295 an absorption curve, with a range (i.e. the shortest to longest to 315 nanometer range selected from Octocrylene, Oxyben wavelengths absorbed) and the peak absorption (i.e. the Zone, Octisalate, Sulisobenzone, Homosalate or Merdimate wavelength which is most highly absorbed). The absorption and mixtures thereof, and the weight of the total composition range and the peak absorption vary by organic molecule. AVobenzone from about 1% to about 5%, Ecamsule 1% to Different organic molecules have differences in how quickly about 10%, Octocrylene 0.5% to about 7%, Oxybenzone their absorption drops off (“fat curves as compared to 0.5% to about 6%, Octisalate 0.5% to about 6%, Sulisoben “skinny’ curves). Zone 0.5% to about 6%, Homosalate 0.5% to about 7% or 0015. It is important to realize that even within an organic Merdimate 0.5% to about 5% and mixtures thereof. molecule's absorption range, it does not absorb evenly and absorptions near the ends of the range are usually low. Sun DETAILED DESCRIPTION OF THE INVENTION screen manufacturers typically use several active ingredients 0022 Samples of vitamin D promoting sunscreen formu for screening different parts of the UV spectrum, thereby lations that were manufactured by the inventor in various providing protection from a broad spectrum of radiation. concentrations were measured using a photospectrometer for 0016 Factors can influence the determination of the their absorption spectra. absorbance maximum and other spectral curve data, both for 0023 Adult humans (two male and two female) have suc UV filters and vitamin D production, and it should be under cessfully applied the vitamin D promoting Sunscreen in vari stood that the overriding essence of the present invention is to ous concentrations to their skin prior to exposure to the Sun, permit vitamin D synthesis by the body while blocking out their initials are: NS, JT, EA, and AG. other harmful wavelengths of radiation. For example, 4-ami 0024. Recent research, in part by the inventor, has demon nobenzoic acid (PABA) has a maximum absorbance between strated that the body has defenses against the harmful effects 300 and 305 nm in its crystalline form, 289 nm when dis of radiation in the Vitamin D producing range. When using a solved in alcohol, and 278 nm when dissolved in water. Sunscreen with one of the current invention's formulations, Therefore, formulations presented in the current invention the user will be protected from unwanted or excess UVB which include or exclude UV filters based all or in part on the radiation for the following reasons: UV filter's absorbance maximum or other spectral curve data 0025. One surprising discovery of the current invention is are not definitive and are subject to change. that from a standpoint of protection from UVB radiation, the 0017. The color of human skin is principally determined pre-vitamin D3 absorbance range (i.e. 295 to 315 nm) has a by two factors: constitutive pigmentation (which is the safety advantage over other ranges of UV radiation absorp genetically-determined color of the skin) and facultative pig tion precisely because of the absorbance by pre-vitamin D3. mentation (which is an acquired tan). About 72 hours after the AS Such, pre-vitamin D3 can be viewed as not only a chemical skin has been exposed to UVB radiation in approximately the with important biological functions but also as a UV filter 295 to 315 nm range, a long-lasting base tan (facultative itself, protecting other biochemicals in its absorbance range. pigmentation) is most noticeable. This delayed tanning is an One critical and distinguishing feature of the current inven increase in melanin, through a process called melanogenesis. tion in regard to the prior art is that others, who are skilled in This invention is a Sunscreen that permits the passage of a the art of Sunscreenformulation, have consistently over many substantial portion of UVB light in the 295 to 315 nanometer years recommended overlapping, broad-spectrum active range, thereby permitting the acquisition of a long-lasting ingredients that effectively filter out radiation in the pre base tan while blocking other harmful wavelengths. The sun Vitamin D3 absorbance range. screen formulations of the current invention are Surprisingly 0026. Urocanic acid acts as a natural, endogenous Sun different from all other sunscreens in that those sunscreens screen or photoprotectant against UVB-induced DNA dam filter abroad-spectrum of light, thereby blocking one's ability age in humans. Urocanic acid is found predominantly in the to get a long-lasting base tan. stratum corneum of the skin. When exposed to UVB irradia 0018 Human exposure to UVA radiation has been associ tion, naturally occurring trans-urocanic acid is converted to ated with melanoma, premature aging, sagging, Wrinkling the cis isomer, which is known to activate Suppressor T cells. skin, Sun spots, tanning and immunologic effects. Formula The absorbance spectrum of trans-urocanic acid is high in the tions of the current invention provide Substantial screening 260 to 295 range, and moderate in the 295 to 315 nm range. across the UVA range. 0027. One surprising discovery of the current invention is that from a standpoint of protection from UVB radiation, SUMMARY OF THE INVENTION Avobenzone's ability to absorb radiation in the 290 to 315 nm. 0019. It is an object of the present invention to create an range actually increases over time. Since avobenzone is a improved Sunscreen promoting tanning and vitamin D gen preferred ingredient, this means that as the Sunscreen user eration, while protecting the skin from damage. spends more time under the sun (i.e. after sufficient vitamin D 0020. This is achieved according to the present invention production has occurred) AVobenzone begins providing bet by a composition Suitable for providing protection against ter coverage in the 280 to 315 nm range. ultraviolet radiation containing one or more active ultraviolet 0028. “Inactive' ingredients can be a misnomer in that radiation absorber through which ultraviolet radiation in they provide UVB protection in minimal amounts. For approximately the 295 to 315 nanometer range is permitted to example, Polycrylene and Octofluorene can be added to the enter the skin in an amount sufficient for the body to produce formulation principally to photostabilize AVobenzone, but in a healthful and disease-opposing quantity of vitamin D and doing so provide some UVB protection. chemical precursors and products thereof. 0029. An unanticipated and surprising advantage of the 0021 Particularly, this composition may comprises one or current invention is that as the vitamin D precursor 1.25(OH) two active ingredient that is primarily a UVA filter selected 2D3 is produced by the body as a result of invention's formu US 2011/0268678 A1 Nov. 3, 2011

lation, that very 1.25(OH)2D3 protects primary human kera 0037. In one combination of the invention, Sulisobenzone, tinocytes against UVB-induced DNA damage. (De Haes P. et Homosalate and Octisalate are each used in lower concentra al., J. Photochem Photobiol B. 2005 February 1-; 78(2):141 tions (5 percent or less because they absorb minimal UVB 8.) radiation); and AVobenzone in a higher concentration (3 to 5 0030 DNA's absorbance spectrum shows high absorption percent, the maximum permitted by law). between 250 and 265 nm, moderate absorbance between 265 0038. In another combination, Homosalate and Octisalate and 290 nm and low to Zero absorbance between 290 and 308 are each used in lower concentrations (5 percent or less nm. In terms of the current invention's Sunscreen formula because they absorb minimal UVB radiation); and Avoben tions, those wavelengths permitted to penetrate the skin are Zone in a higher concentration (3 to 5 percent, the maximum generally in the 290 to 315 nm range, a range poorly absorbed permitted by law). by DNA and RNA. 0039. In another combination, Homosalate and Octisalate 0031 Research has shown that vitamin D has significant are each used in lower concentrations (5 percent or less protective effects against the development of cancer because because they absorb minimal UVB radiation); AVobenzone in it regulates cells growth, cell differentiation and cell death. a higher concentration (3 to 5 percent, the maximum permit Vitamin D works by binding to a receptor in cells. Research ted by law) and Ecamsule in a higher concentration (3 to 10 ers in Italy identified a possible link between melanoma and percent, the maximum permitted by law). a gene involved in vitamin D metabolism. (Cancer, Nov. 1, 004.0 Aspects of some embodiments of the current inven 2008) Genetic differences in the vitamin D receptor gene tion thereby teach away from the long-established mantra of BSmI mean that people may have different levels of vitamin D “broad-spectrum Sunlight blocking and achieve Surprising in their bodies, and some people may have more vitamin and valuable benefits. Some aspects of the current invention D-related protection against cancer than others. According to describe a safe, user-friendly and pragmatic Solution to the the study's authors, these findings indirectly support the problem of preventing vitamin D production in the skin by hypothesis that Sun exposure might have an anti-melanoma broad-spectrum Sunscreens. effect through activation of the vitamin D system. 0041. The appropriate UV filters considered acceptable 0032. The above safety considerations of the current for inclusion in examples of the current invention's formula invention's formulations are Surprising improvements over tions, either alone or in combination with any number of other broad-spectrum Sunscreen formulations. appropriate UV filters, include, but are not limited to, the 0033. It is a contention of the current invention that prior following examples of UV filters which absorb little or no UV art teachings and expectations regarding direct Sunlight are radiation in the vitamin D producing range: flawed and at best imperfect; and that the current invention provides a Surprising and unanticipated improvement overall Selected from the Class of Anthranilates: of this art. 0034 Some formulations of the current invention exclude EXAMPLE 1. active ingredients (UV filters) which block a high percentage 0042 Meradimate (also known as menthyl anthranilate, of those wavelengths of UV radiation used by the body to MA, methyl 2-aminobenzoate or carbomethoxyaniline, CAS manufacture vitamin D and include active ingredients which #: 134-09-8), is an ester of anthranilic acid. Meradimate has permit the passage of a high percentage of the UV radiation an absorption maximum (peak) between 336 and 340 nm, an used to manufacture vitamin D. In essence, Some embodi absorption range between 260 and 380 nm and a critical ments of the current invention anticipate an optimal balance wavelength (CW) of 363 nm. Because of its relative lack of of providing protection from the negative effects of Solar absorption in the vitamin D producing range, Meradimate is radiation or tanning bed radiation while permitting a Suffi cient amount of vitamin D production by the body, thus appropriate as an ingredient in the current invention. providing the best of both worlds. Selected from the Class of Benzophenones: 0035. One embodiment of the current invention using an actual product, one example commercial Sunscreen has four EXAMPLE 2 active ingredients: Homosalate, AVobenzone, Octinoxate and Octisalate. An example formulation of the current invention 0043. Sulisobenzone (also known as Benzophenone-4, would include as active ingredients only Homosalate, Escaiol 577, Uvinul MS 40 or 2-hydroxy-4-methoxyben Avobenzone and Octisalate (because they individually and in Zophenone-5-sulfonic acid, CAS #: 4065-45-6) is an ingre combination with one another block only a fraction of the UV dient in some Sunscreens. Sulisobenzone has an absorption radiation needed for vitamin D synthesis) but would substan range from 260 to 375 nm. Because of its minimal to some tially exclude Octinoxate (because Octinoxate itself blocks a what moderate absorption in the Vitamin D producing range, large percentage of the UV radiation needed for vitamin D Sulisobenzone is generally appropriate as an ingredient in the synthesis. However, trace amounts of Octinoxate may be current invention. present). 0036. Following are examples of combinations of active EXAMPLE 3 ingredients which are appropriate for different embodiments of the current invention (there are many more combinations 0044) Uvinul A Plus (also known as diethylamino possible, and this list is for purposes of demonstration only): hydroxybenzoyl hexyl benzoate or DHHB, CAS #302.776 Sulisobenzone, Avobenzone, Homosalate and Octisalate: 68-7) is used in sunscreens. Uvinul A AVobenzone, Homosalate and Octisalate; Sulisobenzone, 0045 Plus has absorption maxima at about 210 nm and in AVobenzone and Homosalate; Sulisobenzone, Avobenzone the 354 to 357 nm range. and Octisalate; Sulisobenzone and Avobenzone; AVobenzone 0046 Because of its relative lack of absorption in the and Homosalate; as well as AVobenzone and Octisalate. Vitamin D producing range, Uvinul US 2011/0268678 A1 Nov. 3, 2011

0047 A Plus is appropriate as an ingredient in the current Escalol 517, Neo Heliopan 357, Uvinul BMDM or butyl invention. methoxydibenzoylmethane, CAS #: 70356-09-1) is an ingre dient used in Sunscreens. It can exhibit photoinstability. EXAMPLE 4 Avobenzone has an absorption range between 320 and 390 0048 Benzophenone-9 (also known as 2,2'-dihydroxy-4, nm and a maximum absorption of radiation at 360 nm and a 4'-dimethoxybenzophenone-5,5-disodium sulfonate, 2,2'- critical wavelength (CW) of 383 nm. Because of its relative dihydroxy-4,4'-dfmethoxybenzophenone-5,5-disulfonic lack of absorption in the vitamin D producing range, AVoben acid sodium salt or Uvinul D 49, CAS #: 76656-36-5). Zone is appropriate as an ingredient in the current invention. Because of its relative lack of absorption in the vitamin D producing range, BenZophenone-9 is appropriate as an ingre EXAMPLE 10 dient in the current invention. 0054 Eusolex 8020 (also known as Eusolex-8020, 4-iso propyl-dibenzoylmethane, 4-isopropyldibenzoylmethane or EXAMPLE 5 propyl dibenzoylmethane, CAS #: 63250-25-9) is used in 0049. Oxybenzone (also known as 2-hydroxy-4-methoxy sunscreens. Some manufacturers have withdrawn it from the benzophenone, Benzophenone-3, Uvinul M 40, Eusolex market. Because of its relative lack of absorption in the vita 4360 or Escalol 567, CAS #: 131-57-7) is used in sunscreens. min D producing range. EuSolex 8020 is appropriate as an Oxybenzone has an absorption range of 270 to 350 nm and ingredient in the current invention. maxima absorption at 289 nm and at 329 nm. Oxybenzone Selected from Hybrids: has a critical wavelength (CW) of 361 nm. Because its absorption in the vitamin D producing range is minimal to EXAMPLE 11 moderate, Oxybenzone is marginally appropriate as an ingre 0055 Polysilicone-15 (also known as BMP, dimethico dient in the current invention. If included, a low concentration diethyibenzal malonate, dimethicodiethylbenzal malonate, is preferred. or Parsol SLX, CAS #: 207574-74-1) is used in sunscreens. Because of its relative lack of absorption in the vitamin D EXAMPLE 6 producing range, Polysilicone-15 is appropriate as an ingre 0050 Mexenon (also known as 2-hydroxy-4-methoxy-4'- dient in the current invention. methyl-benzophenone, Benzophenone-10 or Mexenone, Selected from the Class of Imidazoles: CAS #: 1641-17-4) is used in sunscreens. Because its absorp tion in the vitamin D producing range is minimal to moderate, EXAMPLE 12 Mexenon is appropriate as an ingredient in the current inven 0056 Bisdisulizole disodium (also known as Neo Helio tion. If included, a low concentration is preferred. pan AP, disodium phenyl dibenzimidazole tetrasulfonate, Selected from the Class of Camphors: bisimidazylate, DPDT or Bisymidazylate, CAS #: 180898 37-7) is added to sunscreens. Bisdisulizole disodium has an EXAMPLE 7 absorption range from 300 to 365 nm and a maximum absorp 0051 Ecamsule (also known as Mexoryi SX, tereph tion at 335 nm. Because of its relative lack of absorption in the thalylidene dicamphor sulfonic acid or TDSA, CAS #: Vitamin D producing range, Bisdisulizole disodium is appro 90457-82-2) is in sunscreens by L'Oreal. Ecamsule has a priate as an ingredient in the current invention. maximum absorbance at 345 nm, provides strong protection Selected from the Class of p-Aminobenzoic Acids: in the 320 to 340 nm range, and weak protection farther out in the fringes in the 290 to 400 nm range. Because it exhibits EXAMPLE 13 only minor absorption in the vitamin D producing range, 0057 PEG-25 PABA (also known as 4-Bis(polyethoxy) Ecamsule is appropriate as an ingredient in the current inven para-aminobenzoic acid polyethoxyethyl ester, p-Aminoben tion. zoic acidor Uvinul P 25, CAS #: 116242-27-4). Because of its Selected from the Class of Cinnamates: minimal absorption in the vitamin D producing range, PEG 25 PABA is appropriate as an ingredient in the current inven EXAMPLE 8 tion. 0052 Octocrylene (also known as Uvinul N 539 T, 2-eth 0058 Selected from the Class of Salicylates: ylhexyl alpha-cyano-beta-phenylcinnamate, alpha-cyano beta-phenylcinnamate or Parsol MCX, CAS #: 6197-30-4) is EXAMPLE 1.4 used as an ingredient in Sunscreens. Octocrylene can stabilize 0059 Homosalate (also known as 3,3,5-trimethylcyclo Avobenzone. Octocrylene has an absorption range from 250 hexyl salicylate, CAS #: 118-56-9) is used in sunscreens. to 360 nm and a maximumabsorption at 303 nm. Octocrylene Homosalate has higher absorption of ultraviolet radiation in has a critical wavelength (CW) of 356 nm. Because its the 300 to 312 nm range, and has a critical wavelength (CW) absorption in the vitamin D producing range is minimal to of 328 nm. Because its absorption in the vitamin D producing moderate, octocrylene is marginally appropriate as an ingre range is minimal to moderate, Homosalate is marginally dient in the current invention. If included, a low concentration appropriate as an ingredient in the current invention. If is preferred. included, a low concentration is preferred. Selected from the Class of Dibenzoylmethanes: EXAMPLE 1.5 EXAMPLE 9 0060 Octisalate (also known as Octyl Salicylate, Escalol 0053 Avobenzone (otherwise known as 4-tert-butyl-4- 587 or 2-ethylhexyl salicylate, CAS #: 118-60-5) is an ingre methoxy-dibenzoylmethane, Parsol 1789, Eusolex 9020, dient in Sunscreens. Octisalate has maximum absorption of US 2011/0268678 A1 Nov. 3, 2011

radiation between about 305 and 307 nm, an absorption range or ET, CAS #: 88122-99-0); Trolamine Salicylate (also between 280 and 320 nm, and a critical wavelength (CW) of known as triethanolamine salicylate or TEA salicylate, CAS 327 nm. Because its absorption in the vitamin D producing #: 002174-16-5); Drometrizole Trisiloxane (also known as range is minimal to moderate, Octisalate is marginally appro DTS, Mexoryl XL, CAS #: 155633-54-8); Bemotrizinol (also priate as an ingredient in the current invention. If included, a known as Tinosorb S, bis-ethylhexyloxyphenol methoxyphe low concentration is preferred. nyl triazine, bis(ethylhexyloxyphenol methoxyphenol) triaz 0061 The examples of UV filters (i.e. active sunscreen ine, BEMT or Anisotriazine, CAS #: 187393-00-6); Iscotriz ingredients) that are included as appropriate active ingredi inol (also known as Uvasorb HEB, diethylhexyl butamido ents are herein meant to be representative and certainly the triazone, dioctylbutamido triazone or DBT, CAS #: 154702 current invention contemplates the inclusion of any molecule 15-5); and Digalloyl trioleate (otherwise known as 5-(3.3-Di based on its ability to fully or partially permit the passage into methyl 2 norbornyliden)-3penten-2-one, CAS #17048-39-4). the skin of UV radiation in approximately the 295 to 315 nm. Because of their absorption in the vitamin D producing range range. the compounds of the formula I as described in US Pub. No.: 0062. Note that the terms “excluded and "inappropriate 2004/0091433 A1 are also inappropriate as ingredients in the for inclusion' used herein are intended to mean that there is 0 current invention. percent concentration, or that there is some Small, trace, Sub 0063. The examples of UV filters that are excluded as stantially ineffective amount present—with examples includ inappropriate active ingredients (noting again that some ing less than 0.1% (wt.), less than 0.05% (wt.), less than Small, trace and ineffective amount may be present) are herein 0.01% (wt), less than 0.25% (wt), or less than 0.001% (wt). meant to be representative and certainly the current invention The inappropriate UV filters which are to be excluded from contemplates the exclusion of any molecule based on its the current invention's formulations, include, but are not lim ability to fully or amply block the passage into skin of UV ited to, the following UV filters demonstrating a high percent radiation in approximate the 295 to 315 nm range. Other UV age of the UV radiation absorption in the vitamin D producing filters are listed as substances in the CTFA International Cos range: Benzophenone (CAS #: 119-61-9); 2,4-Dihydroxy metic Ingredient Dictionary, or are approved by the appropri benzophenone (Benzophenone-1, CAS #: 131-56-6); 2.2.4. ate regulatory agencies in Australia, Canada, China, EU, 4'-Tetrahydroxybenzophenone (Benzophenone-2 or Uvinul Japan, Sweden, The Netherlands, UK or USA; or are cleared D50, CAS #: 131-55-5): 2,2'-Dihydroxy-4,4'-dimethoxyben by the US Cosmetic Ingredient Review (CIR) group, all of Zophenone (Benzophenone-6, CAS #: 131-54-4): 2,2'-Dihy which are which is incorporated in the current invention by droxy-4-methoxybenzophenone (Benzophenone-8, Dioxy way of reference. benzone, CAS #: 131-53-3); 2-Hydroxy-4-(Octyloxy) 0064. The following representative examples of ingredi Benzophenone (Benzophenone-12, Octabenzone, CAS #: ents may or may not be selected as appropriate for inclusion 1843-05-6): 4-Methylbenzylidene camphor (also known as in the present invention, with one determining factor being an 4-MBC, Uvinul MBC95, Enzacamene, Eusolex 6300, Parsol absorbance curve with an amplitude and breadth that permit 5000 or 3-(4-methylbenzyliden)camphor, CAS #:36861-47 Sufficient radiation in the vitamin D producing range (ap 9); Cinoxate (also known as 2-ethoxyethyl p-methoxycin proximately 295 to 315 nm) to enter the skin thereby produc namate, CAS #: 104-28-9); Octinoxate (also known as octyl ing a healthful, disease-opposing amount of vitamin D: 2-(2- methoxycinnamate, OMC, Uvinul MC 80, Neo Heliopan AV. Hydroxy-5-methyl-phenyl)Benzotriazole (Drometrizole, Parsol MCX or ethylhexylmethoxycinnamate, CAS #: 5466 CAS #: 2440-22-4); 2-Hydroxy-4-methoxybenzophenone-5- 77-3); Diethanolamine p-methoxycinnamate (also known as sulfonic Acid, Monosodium Salt (Benzophenone 5, CAS #: Diethanolamine methoxycinnamate or DEA methoxycin 6628-37-1): 2-Hydroxyethyl salicylate (CAS #: 87-28-5): namate, CAS #: 56265-46-4); Isoamyl p-methoxycinnamate 3-Benzylidene camphor, (also known as 3BC, CAS #15087 (also known as, Isopentenyl-4-methoxycinnamate, IMC, Neo 24-8): 3-2-(4-diethylaminophenyl)-2-oxoethylthiazolium Heliopan E1000 or Amiloxate, CAS #: 71617-10-2); Diben salt; 5-Chloro-2-hydroxybenzophenone (Benzophenone-7, Zoylmethane (also known as clibenzoyl methane, CAS #: CAS #: 85-19-8); Aesculetin (also known as esculetin, 6.7- 120-46-7); Bisoctrizole (also known as Tinosorb M. methyl dihydroxycoumarin and cichorigenin); Artemia salina plank ene bis-benzotriazolyl tetramethylbutyl phenol or MBBT. ton extract, BenZophenone-5 (also known as Benzene CAS #103597-45-1); Zinc oxide (also known as ZnO): Tita sulfonic acid, CASi6628-37-1); Benzyl salicylate (CAS #: nium dioxide (also known as titanium (IV) oxide, TiO2 or 118-58-1); Benzylidene Camphor Sulfonic Acid (CAS #: titania); Cerium(V) oxide (also known as ceria, cerium oxide 56039-58-8); Beta, 2-glucopyranoxy propyl hydroxy ben or CeO2); Ensulizole (also known as phenylbenzimidazole Zophenone; Bis(2.4-ihydroxyphenyi)Methanone (Benzophe Sulfonic acid, phenylbenzimidazole, 2-phenylbenzimida none-11, Benzophenone-n, Uvinul M 493,CAS if: 1341-54 Zole-5-Sufonic acid, PBSA, Parsoi HS, CAS #: 27503-81-7); 4); Bornelone (CAS #: 2226-11-1); Broccoli sprout extracts Aminobenzoic acid (also known as 4-aminobenzoic acid, including Sulforaphane; brown algae polyphenols (BAPs), p-aminobenzoic acid or PABA, CAS #: 150-13-0); Padi Camphorbenzalkonium methosulfate, (also known as Mexo mate-0 (otherwise known as Padimate O. Ethylhexyl dim ryl SO CASH52793-97-2); Dibenzoylmethane (CAS #: 120 ethyl PABA, 2-ethylhexyl 4-dimethylaminobenzoate, 46-7); Dibenzylideneacetone (also known as dibenzalacetone Escalol 507, octyl dimethyl PABA or OD-PABA, CAS #: or dba); Dihydroxyacetone; Diisopropyl methyl cinnamate 21245-02-3); Padimate-A (also known as amyl p-dimethy (CAS #32580-71-5); Dimethicodiethylbenzal mafonate: laminobenzoate, amyl paradimethylaminobenzoate or amyl Dimethoxyphenyl-1-(3,4)-4.4 dimethyl 1.3 pentanedione: dimethyl PABA, CAS #21245-01-2.); Glyceryl Aminoben Dipropylene glycol salicylate; Diurethane dimethacrylate Zoate (also known as glyceryl p-aminobenzoate, glyceryl (CAS #: 103597-45-1); Endocannabinoids; Ethyl 2-cyano-3, PABA, glyceryl 1-(4-aminobenzoate), monoglyceryl ester or 3-diphenylacrylate (Etocrilene, CAS #: 5232-99-5); Ethyl Lisadimate, CAS #: 136-44-7); Ethylhexyl Triazone (also 4-bis(hydroxyl propyl)aminobenzoate (also known as pro known as Octyl Triazone, ethylhexyl triazone, Uvinul T 150 poxylate of p-aminoethylbenzoate or Roxadimate, CAS #: US 2011/0268678 A1 Nov. 3, 2011

58882-17-0); Ethyl Cinnamate (CAS #: 103-36-6); Ethyl sunscreen that is only one forth of the recommended thick dihydroxypropyl PABA: Ethyl Diisopropylcinnamate (CAS ness. Generally the thickness is measured in layers 2, 1 and #: 32580-72-6); Ethyl Methoxycinnamate (CAS #: 99880 0.5 mg/cm2 deep. This thickness question could affect the 64-5); Ethyl PABA (also known as benzocaine); Ethyl Uro inclusion or exclusion decision. Such differences could con canate (CAS #: 27538-35-8); Ethylhexyl dimethoxy ben ceivably influence the decision to include or exclude the UV Zylidene dioxoimidazoline propionate; Ferulic acid; filter candidate, any Such change from the inclusionary list to Forskolin; Glyceryl ethylhexanoate dimethoxycinnamate: the exclusionary list (or vice-versa) is contemplated by the Glyceryl octanoate dimethoxycinnamate; Isopropylbenzyl current invention without detracting from the essence. For Salicylate (CAS #: 94134-93-7); Isopentyl trimethoxycin example, shifts in the absorbance curves for oxybenzone, namate trisiloxane: Isopropyl methoxycinnamate(CAS #: TDSA and Bisdisulizole disodium have been reported as a 5466-76-2); Lawsone; Magnesium aluminum silicate, Men result of the base (TEA or NaOH) used to neutralize the thyl salicylate (CAS #: 89-46-3); p-Aminobenzoic Acid, 2,4- sample. dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanimide 0068. The concentrations of each of the active ingredients ester; Petrolatum jelly (CAS #: 8009-03-8); Phenylbenzimi in the current invention can vary, resulting in SPF numbers dazole; Phenylbenzimidazole Tea sulfonate (CAS #: 73705 from 2 to 50 plus reflecting the product’s ability to protect 00-7); Polyacrylamido methylbenzylidene camphor (CAS from Sunburn (erythema) and low, medium, high or highest #113783-61-2); QuickSun Clear and QuickSun Matte “Star” (or other rating) to reflect its ability to block UVA extracts; Salicylic acid; Sodium Phenylbenzimidazole sul radiation; the essential being that the concentrations permit fonate (CAS #: 5997-53-5); Sorbohydroxamic acid; Umbel the synthesis of at least ahealth-promoting amount of vitamin liferone (also known as 7-hydroxycoumarin); and Urocanic D. Acid (4-Imidazoleacrylic acid, CAS #: 104-98-3) and each of 0069. In addition to sunscreens, whose primary purpose is their respective metabolites, acids, hydroxyl groups, esters, medicinal Sunscreening (preventing UV radiation from harm salts, alcohols, acyl groups, related chemical species, phar ing the skin), the current invention can be applied to making maceutically-acceptable salts thereof and the like. the therapeutic claim that is does not prevent vitamin D pro 0065. Additional organic screening agents may be duction in cosmetic products including but not limited to hair selected for said inclusion especially from: the anthranilates, products, lip balms, creams, lotions, sprays, insect repellants benzylidenecamphors, benzimidazoles, benzotriazoles, cin and make-up which often also include a UV filter. namates, dibenzoylmethanes, imidazolines, PABAS, salicy 0070 There are wavelengths of radiation other than lates, triazines and nucleic acids including DNA and RNA. approximately 295 to 315 nm (those in the vitamin D range) 0066. In addition to the specific examples of UV filters which can be beneficial to the body as well. provided as appropriate or inappropriate for inclusion in the 0071. Depending on the formulation, the current patent present invention's formulations are each of their respective can include or exclude active ingredients in order to permit metabolites, acids, hydroxyl groups, esters, salts, alcohols, other health-enhancing wavelengths to enter the skin. acyl groups, related chemical species, pharmaceutically-ac 0072. In one embodiment of a method of the invention, a ceptable salts thereof and the like. Vitamin Denhancing Sunscreen with a formulation as per the 0067. There are various factors that one must consider current invention is applied to the skin first, and then, if the when selecting the appropriate active and inactive ingredients Sunscreen user desires to remain in the Sun for an extended for the current invention, remembering always that the guid exposure (i.e. long enough to potentially induce erythema), ing light in that decision is always a balance between making the person may then apply a second or third coat of Sunscreen it possible for the body to manufacture an adequate amount of which contains UVB blocking ingredients herein defined as Vitamin D and preventing excessive adverse effects to the skin inappropriate for vitamin D production. The result being that from the sun. Those factors involved in the selection of appro by the time of the second application, the body will have priate ingredients include, but are not limited to, the follow already produced sufficient vitamin D for proper health for ing. Study reports presenting the UV radiation absorbance the day. The period of time before applying the second Sun ranges and maxima (i.e. molar absorbance coefficients) for screen should be sufficient to allow an effective amount of the active ingredients, inactive ingredients and vitamin D Vitamin D to be absorbed. Examples include at least about 10 production can vary depending upon which solvent medium minutes, at least about 20 minutes, at least about 30 minutes, (e.g. water, methanol, acetonitrile, n-hexane) is used when the and at least about 1 hour. molecule's spectral data is collected, the type of the spectro 0073. In one embodiment, a vitamin D enhancing sun photometric measurements, the calibration of the instrumen screen with a formulation as per the current invention is tation, pollutants in the samples, the pH of the samples, water applied to certain areas of the body at the same time as an in-oil, oil-in-water, the examination in vivo or in vitro, the additional sunscreen which has UVB blocking ingredients concentration of the molecule, the length of time the molecule (and perhaps other inactive ingredients such as moisturizers) was been exposed to radiation, the presence or absence of herein defined as inappropriate is applied to other areas. For other molecules, the intensity of radiation to which the active example, a Sunscreen user may wish to use a Sunscreen with ingredient has been exposed, the degradation of the molecule, inappropriate ingredients on his or her face at the same time as skin types, the presence or absence of SPF boosters such as a Sunscreen with only appropriate ingredients on his or her glass beads, UV-Pearls and microcapsules or ingredients to arms and legs. improve photostability such as antioxidants and Triplet-Trip 0074 The current invention may be specially formulated let Quenches, and the interpretation of the data. The current for use on humans of differentages, with increased vitamin D invention acknowledges that not all people applying Sun production especially preferred in the elderly, and certain screen apply it as thickly as others, and that generally the considerations such as waterproof for children. thicker it is applied, the better the UV protection. It has been 0075. The current invention may be formulated for use on reported that Sunscreen users on average apply a layer of domestic animals such as horses, dogs and cats; and on farm US 2011/0268678 A1 Nov. 3, 2011

animals. Increasing vitamin D levels in farm animals such as based partially on their absorbance or non-absorbance of cows, pigs and goats provides health benefits to the farm radiation in the range that produces vitamin D: Acrylates; animals and, Surprisingly, increases the vitamin D content of C10-30 alkyl acrylate crosspolymer; alcohol (ethyl-, isobu their milk and meat, a health benefit to the humans who tyl-, isopropyl-, methyl-, prop-, and butyl-alcohol or other consume them. alcohols), allantoin; allantoin-p-aminobenzoic acid complex 0076 Some embodiments of the present invention are for p-aminobenzoic acid; aluminum; aloe Vera leaf juice; aloe adults, others for children and embodiments may be formu Vera, aloe barbadensis leaf juice; alumina; amyl acetate; amyl lated as a lotion, cream, gels, oil, spray, emulsion, Solution, dimethyl PABA; amyl para-dimethylaminobenzoate: amyi moisturizer, ointment, transdermal delivery system for other p-dimethylaminobenzoate; antibacterial agents; antifungal molecules, make-up, foundation, shampoo, Soap, spray, Stick, agents; antioxidants; aromatic amino acids (such as phenyla lip balm and the like; can be made sticky, non-sticky, water lanine; tryptophan; and tyrosine); ascorbyl palmitate; Baobab proof water resistant, abrasion resistant or rub-proof, rinse pulp; beeswax; benzyl alcohol; BHA; BHT: 2-bromo-2-ni off, leave-on and the like; and can contain humectants, emul tropropane-1,3-diol; buffers such as PBS or HEPES; borage sifiers, emollients, preservatives and thickeners and the like. seed oil; carrot oil; camphor; caprylic/capric triglyceride; Other Sunscreen ingredients may include anti-irritants, and Carbomer 934; carboset; cellulose gum; cetyl alcohol; cetyl products which help cell communication (signaling), and palmitate, cetyl Stearylglycol, cetearyl alcohol; cetyl alcohol; which mimic the structure and function of the skin. cetyl PEG/PPG-10/1 dimethicone; cinoxate citric acid; clove 0077. The antioxidants or free-radical scavengers that oil; co-enzyme Q10; cocoa butter, coconut oil; collagen; may be used in the composition according to the invention colorants; controlled release agents; Coolact 10 (INCI: Men comprise, besides certain anti-pollution agents mentioned thoxypropanediol); creatine; dasheen root extract; dielectric above, vitamin E and its derivatives such as tocopheryl spheres; dihydroxyacetone (self-tanning ingredient); diaZo acetate; Vitamin C, panthenol (provitamin B5), retinyl palmi lidinyl urea; dibutyl adipate; disodium EDTA; dimethicone; tate (vitamin A palmitate), bioflavonoids; coenzyme Q10 or 5-(3: 3-dimethyl-2-norbornyliden)-3-penten2-one; 3: 4-dim ubiquinone; certain enzymes, for instance catalase, SuperoX ethylphenyl-glyoxylic acid sodium salt; dimethyl polysilox ide dismutase, lactoperoxidase, glutathione peroxidase and ane; dipropylene glycol salicylate; DMSO; dyes; edelweiss; quinone reductases; glutathione; benzylidenecamphor; ben elastin, emollients: Emu oil, Emulium Kappa; ethyl alcohol; Zylcyclanones; Substituted napthalenones; pidolates; phytan 2-ethylhexyl 4-phenylbenzophenone-2-carboxylic acid; eth etriol: gamma-ory Zanol; lignans; and melatonin as well as all ylhexyl palmitate; ethylenediamine; eucalyptus leafoil; feru of their respective salts, analogues and metabolites. lic soy glycerides (FSG); fruit extracts (such as guava; 0078. In one embodiment, Spectrasolv technology is used mango; papaya; passionflower); FD&C yellow No. 5: FD&C to formulate the dielectric constant of the oil phase to that at red No. 4; fragrances; galactoarabinan; glycerin; glyceryl which Avobenzone is made most stable. In one preferred PABA; glyceryl Stearate; hemp seed oil; hydroxyacetone embodiment, Avobenzone is photostabilized with Octofluo (self-tanning ingredient); isohexadecane; isopropyl rene by Hallstar or other manufacturer. At use levels of 1 to 2 myristate; isopropyi palmitate; jojoba oil; kukui nut (seed) percent, Octofluorene absorbs UV radiation in such minimal extract; lanolin; lanoilin alcohol; lanolin derivatives; lanolin amounts as not to affect SPF or vitamin D synthesis, and its oil; lawsone (2-hydroxy-1, 4-naphthoquinone); magnesium absorbance spectrum fits well in that most of its absorption is aluminum silicate; menthol; metallic pigments; microcap in the UVA range. In one preferred embodiment, AVobenzone sules such as UV-Pearls; microcrystalline titanium coated is photostabilized and made water resistant with Polycrylene mica platelets; microcrystalline wax, mircospheres; mineral (INCI Name: Polyester-8 and CAS: 862993-96-2) by Hallstar oil; neopentyl glycol; oleth-3; oleth-3-phosphate; C30-38 or other manufacturer. At use levels of 1 to 2 percent, Poly olefinfisopropyl maleate/MA copolymer; oZokerite; pan crylene absorbs UV radiation in Such minimal amounts as not thenol; parabens (ethyl-, isobutyl, isopropyl-, methyl-, prop-: to affect SPF or vitamin D synthesis. Polycrylene also and butyl-propylparabens); Padina extract; paraffin: PEG 2 improves the Substantivity of sunscreenformulations as mea Stearate; PEG-8; penetration enhancers (such as terpenes and sured by resistance to wash-off. In one preferred embodi terpenoids); perfumes; petrolatum: phenoxy-ethanol; phe ment, AVobenzone is photostabilized using Hawaiian Trop noxyethanol: 2-phenylbenzimidazole; photostability ic's SunSure proprietary combination of ingredients. improvers such as Corapan TQ (diethylhexyl 2: 6-naphtha 0079. In addition to the particular molecules presented in late) and Triplet-Triplet Quenches; polymers (including poly lists of UV filters (both appropriate and inappropriate); the mers to assist in dispersion and rheology); propylene glycol, current patent contemplates the inclusion or exclusion of their polyoxyl-40-Stearate; plumeria extract; polysorbate 60; pro respective metabolites, acids, hydroxyl groups, esters, salts, pellant 46; propellant 12/114; propoxylate of p-aminoethyl alcohols, acyl groups, pharmaceutically acceptable carriers, benzoate; propylparaben; propylene glycol; propylene glycol and other related chemical species thereof. Stearate; proteins (such as proteins which are rich in aromatic 0080. In one preferred embodiment, a UV booster for amino acids Such as keratin and albumin); Quaternium 15; red organic Sunscreen actives such as the citrate ester Trimollient petrolatum; retinoic acid; retinol; rice extract; rose petal BC (INCI: Tris PPG-3 benzylcitrate) provides benefits in sun extract; safflower seed oil (Hydresia): SD alcohol 40; SPF protection. boosters such as glass beads; sesame oil; shea butter, silaca 0081. Some ingredients which are somewhat erroneously Sodium carbomer, sodium ascorbyl phosphate; sodium cet referred to as “inactive' ingredients in sunscreens, for earyl Sulfate; sodium citrate; sodium chloride; sodium example unrefined shea butter, coconut oil and other oils, are hydroxide; sorbitan oleate; sorbitan stearate; sorbitol; stabi known to have mild UV blocking properties. The following lized aloeveragei; Stearic acid; Stearyl alcohol; Stearylhydro ingredients, (with others possible in keeping with the vitamin genated dimmer dilinoleate copolymer; Sunflower oil; Syn Denhancing teachings of the current invention), may or may thetic spermaceti; theobroma Cocao (cocoa) seed butter; not be included in the formulation of the current invention tocopheryl acetate; triethanolamine Stearate; Vitamins such as US 2011/0268678 A1 Nov. 3, 2011

A. C. E.; D: B3; B6; B12: water; watermelon (Citrullus lana balm, insect repellant, make-up, waterproof agent, penetra tus), wax, wheat (triticum Vulgare); Wolfberry (goji berry); tion enhancer, encapsulated, emulsion, liquid solvent, emol germ oil: X-TendTM 226 (a polar ester with high-solubilizing lient, organic chemical stabilizer, and mixtures thereof. capacity for Oxybenzone and AVobenzone); Xanthan gum, 12. The composition of claim 1 wherein the composition is and each of their respective metabolites, acids, hydroxyl a Sunscreen that is applied one or more times in a safe and groups, esters, salts, alcohols, acyl groups, related chemical effective amount to the skin prior to, during, or prior to and species, pharmaceutically-acceptable salts thereof and the during exposure to light from the Sun or tanning bed. like. 13. The composition of claim 1 wherein the composition is 0082. When considering the various embodiments of the a Sunscreen that is applied to the skin of humans; companion invention described herein, those knowledgeable in the art animals such as dogs and cats; and farm animals such as will appreciate that these are illustrative only. Such embodi horses, cows, pigs and goats. ments do not limit the scope of the invention. Those knowl 14. (canceled) edgeable in the art involved will appreciate that many varia 15. The composition of claim 1 wherein the composition is tions, Substitutions, equivalents, and like modifications may used alone, with Vitamin D. Supplementation, with Vitamin be made within the scope of the present invention. D. Supplementation, or mixtures thereof. What is claimed is: 16. The composition of claim 1 wherein the composition is 1. A composition Suitable for providing protection against used on part, or essentially all of the body. ultraviolet radiation containing one or more active ultraviolet 17. The composition of claim 1 wherein the composition is radiation absorber through which ultraviolet radiation in applied on part of the body while a full-spectrum Sunscreenis approximately the 295 to 315 nanometer range is permitted to applied on other parts of the body. enter the skin in an amount sufficient for the body to produce 18. The composition of claim 1 wherein the composition is a healthful and disease-opposing quantity of vitamin D and applied first and then after a period of between about 5 min chemical precursors thereof. utes and 12 hours a full spectrum Sunscreen is applied. 2. The composition of claim 1 wherein the composition is 19. The composition of claim 1, wherein all active ultra a Sunscreen that further comprises one or more ultraviolet violet radiation absorbers are eliminated. radiation absorber, wherein the one or more ultraviolet radia 20. The composition of claim 19, wherein the composition tion absorber is applied in the amounts of between 0.01 and eliminates one or more ultraviolet radiation absorber, 50 milligrams of lotion per square centimeter of skin. wherein the one or more ultraviolet radiation absorber is 3. The composition of claim 1 wherein the composition is Selected from the group consisting of BenZophenone, 2,4- a Sunscreen that further comprises one or more ultraviolet Dihydroxybenzophenone, 2,2,4,4'-Tetrahydroxybenzophe radiation absorber, wherein the one or more ultraviolet radia none, 2,2'-Dihydroxy-4,4'-dimethoxybenzophenone, 2,2'- tion absorber is selected from the group consisting of Meradi Dihydroxy-4-methoxybenzophenone, 2-Hydroxy-4- mate, Sulisobenzone, Uvinul A Plus, BenZophenone-9, Oxy (Octyloxy)Benzophenone, 4-Methyibenzylidene camphor, benZone, Mexenon, Ecamsule, Octocrylene, AVobenzone, Cinoxate, Octinoxate, Diethanolamine p-methoxycin Eusolex 8020, Polysilicone-15, Bisdisulizole disodium, namate, Isoamyl p-methoxycinnamate, Dibenzoylmethane, PEG-25 PABA, Homosalate, Octisalate, and mixtures, phar Bisoctrizole, Zinc oxide, Titanium dioxide, Cerium(IV), maceutically-acceptable salts, and metabolites thereof. Ensulizole, Aminobenzoic acid, Padimate-O, Padimate-A, 4. (canceled) Glyceryl Aminobenzoate, Ethylhexyl Triazone, Trolamine 5. (canceled) Salicylate, Drometrizole Trisiloxane, Bemotrizinol, Iscotriz 6. The composition of claim 3 which comprises based on inol, Digalloyl trioleate, and mixtures, pharmaceutically-ac the weight of the total composition Avobenzone from about ceptable salts, and metabolites thereof. 1% to about 5%, Octisalate from about 1.1% to about 4.2%, 21. (canceled) and Oxybenzone from about 0.9% to about 3.6%. 22. (canceled) 7. (canceled) 23. (canceled) 8. (canceled) 24. (canceled) 9. The composition of claim 1 wherein said healthful and 25. (canceled) disease-opposing quantity of vitamin D and chemical pre 26. (canceled) cursors thereof raises the serum 25-hydroxyvitamin D. by 27. A method for promoting formation of vitamin D and between 1 and 100 ng/mL for each minimal erythemal dose of chemical precursors thereof comprising the steps of applying skin exposure to ultraviolet radiation. a lotion to the skin that includes one or more ultraviolet 10. The composition of claim 1 wherein said healthful and radiation absorber selected from the group consisting of disease-opposing quantity of vitamin D and chemical pre Meradimate, Sulisobenzone, Uvinul A Plus, Benzophenone cursors thereofraises vitamin D levels sufficiently to prevent 9. Oxybenzone, Mexenon, Ecamsule, Octocrylene, Avoben or treat osteopenia, osteoporosis, osteomalacia, rickets, bac Zone, Eusolex 8020, Polysilicone-15, Bisdisulizole diso terial infections, viral infections, multiple Sclerosis, rheuma dium, PEG-25 PABA, Homosalate, Octisalate, and mixtures toid arthritis, breast cancer, ovarian cancer, colorectal cancer, thereof; and that contains substantially Zero ultraviolet radia prostate cancer, non-Hodgkin's lymphoma, Hodgkin's lym tion absorber selected from the group consisting of Ben phoma, influenza, type 1 diabetes mellitus, type 2 diabetes Zophenone, 2,4-Dihydroxybenzophenone, 2.2',4,4'-Tetrahy mellitus, obesity, lupus, hypertension, stroke, myocardial inf droxybenzophenone, 2,2'-Dihydroxy-4,4'- arction, periodontitis, and dementia. dimethoxybenzophenone, 2,2'-Dihydroxy-4- 11. The composition of claim 1 wherein the composition is methoxybenzophenone, 2-Hydroxy-4-(Octyloxy) a Sunscreen that is applied to the skin in conjunction with a Benzophenone, 4-Methylbenzylidene camphor, Cinoxate, cosmetically and pharmaceutically carrier Suitable for topical Octinoxate, Diethanolamine p-methoxycinnamate, Isoamyl application Such as a lotion, cream, spray, moisturizer, gel, lip p-methoxycinnamate, Dibenzoylmethane, Bisoctrizole, Zinc US 2011/0268678 A1 Nov. 3, 2011

oxide, Titanium dioxide, Cerium(IV), Ensulizole, Ami violet radiation absorber is applied in the amounts of between nobenzoic acid, Padimate-O, Padimate-A, Glyceryl Ami 0.01 and 50 milligrams of lotion per square centimeter of nobenzoate, Ethylhexyl Triazone, Trolamine Salicylate, skin. Drometrizole Trisiloxane, Bemotrizinol, Iscotrizinol, Digal 29. (canceled) loyl trioleate, and mixtures, pharmaceutically-acceptable 30. (canceled) salts, and metabolites thereof. 31. (canceled) 28. A composition Suitable for providing protection against 32. (canceled) ultraviolet radiation containing one or more active ultraviolet 33. The composition of claim 28 which comprises based on radiation absorber through which ultraviolet radiation in the weight of the total composition Avobenzone from about approximately the 295 to 315 nanometer range is permitted to 1% to about 5%, Octisalate from about 1.1% to about 4.2%, enter the skin in an amount sufficient for the body to produce and Oxybenzone from about 0.9% to about 3.6%. noticeable facultative pigmentation (tanning), wherein the 34. (canceled) composition is a Sunscreen that further comprises one or more ultraviolet radiation absorber, wherein the one or more ultra