US 20110268678A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2011/0268678 A1 Armstrong (43) Pub. Date: Nov. 3, 2011 (54) VITAMIND FORMING SUNSCREEN A6IP35/00 (2006.01) A6IP3 L/16 (2006.01) (76) Inventor: Ernest T. Armstrong, Palm Desert, A6IP3/10 (2006.01) CA (US) A6IP3/04 (2006.01) A6IP 9/04 (2006.01) (21) Appl. No.: 13/143,180 A6IP 9/12 (2006.01) A6IP 9/10 (2006.01) A6IP 25/28 (2006.01) (86). PCT No.: PCT/B2009/055881 A61O 1704 (2006.01) A6IR 8/35 (2006.01) S371 (c)(1), A6IR 8/31 (2006.01) (2), (4) Date: Jul. 1, 2011 A6IR 8/37 (2006.01) Related U.S. Application Data A61K 8/46 (2006.01) (60) Provisional application No. 61/204,146, filed on Jan. (52) U.S. Cl. ............................................. 424/60; 424/59 5, 2009. (57) ABSTRACT Publication Classification A composition Suitable for providing protection against ultra (51) Int. Cl. violet radiation containing one or more active ultraviolet A6 IK 8/4I (2006.01) radiation absorber through which ultraviolet radiation in A6IP 9/00 (2006.01) approximately the 295 to 315 nanometer range is permitted to A6IP 9/10 (2006.01) enter the skin in an amount sufficient for the body to produce A6IP 9/08 (2006.01) a healthful and disease-opposing quantity of vitamin D and A6IP3/04 (2006.01) chemical precursors thereof. The composition is particularly A6IP3L/2 (2006.01) used in Sunscreens promoting on the one hand vitamin D. A6IP37/00 (2006.01) production, on the other hand protecting the skin against A6IP 29/00 (2006.01) harmful ultraviolet radiation. US 2011/0268678 A1 Nov. 3, 2011 VITAMIND FORMING SUNSCREEN terrestrial vertebrates, including humans, obtain most of their Vitamin D requirement from casual exposure to Sunlight. CROSS REFERENCE TO RELATED Application of a Sunscreen, increased skin pigmentation, APPLICATION aging, hair and clothing all reduce vitamin D production in the skin. 0001. This application claims the priority right from the 0009 Vitamin D is made in the body when a derivative of U.S. provisional patent application 61/204,146 that was filed cholesterol called 7-dehydrocholesterol is converted to pre on Jan.5, 2009, the content of which is herewith incorporated Vitamin D3 using the energy from radiation that has entered in its entirety by reference. Also, this application is a national the skin. Pre-vitamin D3 then spontaneously changes itself phase entry under 35 U.S.C. S371 based on PCT/IB2009/ into its isomer, vitamin D3. Vitamin D3 is then changed to 055881 filed on Dec. 21, 2009. 25-hydoxyvitamin D3 which circulates in the blood serum or is stored in the liver until needed. 25-hydroxyvitamin D3 is BACKGROUND OF THE INVENTION later changed in the kidneys or elsewhere into 1,25-dihydrox 0002 One aspect of the invention is directed to sunscreen yvitamin D3, the main biologically active form. formulations that protect the skin against the damaging 0010. Following are synonyms: pre-vitamin D3 is chole effects of sunlight while providing the health benefits of calciferol; 25-hydoxyvitamin D3 is 25(OH)D3 or calcidiol; increased vitamin D production by the body is disclosed. 1,25-dihydroxyvitamin D3 is 1,25(OH)2D3 or calcitriol. in Another aspect is directed to methods for applying Sun this patent vitamin D stands for vitamin D3, and is sometimes SCCS. used in a general sense. 0003. One example embodiment of the current invention 0011. The amount of sunscreen (or sunblock) applied to is a Sunscreen formulation with active ingredients that screen the skin can influence how much of the incoming UV radia as much of the damaging, cancer-causing ultraviolet radiation tion is absorbed, with a thicker layer generally absorbing as possible while at the same time permitting passage of light more radiation. The current invention eliminates certain in the wavelengths used by the body to synthesize vitamin D active ingredients which are known to be sticky or oily, espe and for tanning. cially in higher concentrations. One advantage of the current 0004 Sunscreens are widely known and used to prevent invention over traditional Sunscreen concoctions is, Surpris the harmful affects of sun exposure. Each different active ingly, overall better skin protection because the behavior of ingredient used in Sunscreens has a unique profile in regard to Sunscreen users is such that they tend to use larger quantities which wavelengths of ultraviolet (UV) radiation it can absorb and tend to re-apply more frequently when the ingredients are and what percentage of those wavelengths it can absorb. not as sticky or oily. Traditionally sunscreen formulators, in their zeal to protect 0012. The action spectrum of epidermal vitamin D photo people who are exposed to Sunlight from skin cancer and synthesis can be graphed in an absorbance curve showing that wrinkles, have combine complimentary active ingredients to the peak absorbance for vitamin D synthesis is at about 297 filter UV radiation in a spectral overlap that screens the broad nm, with large amounts produced between 295 and 305 nm, est spectrum of radiation possible. This broad spectrum and lesser amounts produced farther from the peak of the approach, unfortunately, also blocks the beneficial wave curve between 290 and 295 nm and between 305 and 315 nm. lengths of radiation in approximately the 295 to 315 nanom (Wavelengths between 270 and 290 nm will cause vitamin D eter range which are needed for vitamin D synthesis in the synthesis, but are for the most part filtered by the atmosphere, skin. and therefore generally do not reach the body.) As the wave 0005. There is broad agreement by vitamin D researchers lengths increase from 290 to 315 nm, so does the relative that getting quantities of vitamin D that are sufficient for intensity of UVB radiation reaching the earth's surface. optimum health from diet alone is difficult, that vitamin D is Therefore as a practical matter, it has been discovered that produced in Sufficient quantities when a sensible amount of although the absorbance by Vitamin D precursors is highest in Sunlight at lower latitudes penetrates the skin and that a large the 295 to 300 nm range, there is at the surface of the earth a percentage of the population would benefit from higher levels higher intensity of UVB radiation available to the skin of vitamin D. between 300 and 305 nm than is available between 295 to 300 0006 Vitamin D plays an essential role in the prevention of bone problems (of which one in twelve people living in 0013 An important consideration of the current invention higher latitudes is at risk), prevention of Some sixteen com is that although the range of radiation that is filtered by the mon cancers (which together are responsible for 30 times current invention's appropriate UV filter(s) may overlap part more deaths than skin cancer) and modulation of neuromus ofall of the absorption range needed for vitamin D production cular and immune function. Research also indicates that Suf (i.e. approximately 295 to 315 nm), the active ingredient(s) of ficient levels of vitamin D may prevent or reduce the inci the current invention permit the passage of Sufficient quantity dence of inflammation, multiple Sclerosis, rheumatoid and quality of radiation for the body to effectively produce arthritis, hypertension, lupus, cardiovascular disease, type 1 Vitamin D. The current invention discloses a Surprising diabetes and type 2 diabetes. Obesity is associated with lower improvement in Sunscreen formulation that teaches away circulating vitamin D levels. from mainstream full-spectrum screening approach. 0007 Disclosed are significant, untapped health benefits 0014 Organic molecules known as UV filters (i.e. the and considerable commercial potential by the current inven active ingredients in Sunscreens) have multiple atoms which tion. can vibrate and rotate in relation to each other. Many closely 0008 Vitamin D is a fat-soluble vitamin that is naturally spaced energy transitions mean that instead of absorbing present in very few foods, added to others, available as a exact frequencies of radiation, molecules absorb groups of dietary supplement and produced when ultraviolet (UV) rays frequencies of radiation. The many closely spaced absorption from Sunlight (or tanning beds) enter the skin. Essentially all lines combine to make an absorption band. Sunscreens made US 2011/0268678 A1 Nov. 3, 2011 from organic molecules absorb different percentages of the from AVobenzone or Ecamsule and one or more active ingre radiation. These percentages of absorption can be graphed as dient that filters ultraviolet radiation in approximately the 295 an absorption curve, with a range (i.e. the shortest to longest to 315 nanometer range selected from Octocrylene, Oxyben wavelengths absorbed) and the peak absorption (i.e. the Zone, Octisalate, Sulisobenzone, Homosalate or Merdimate wavelength which is most highly absorbed). The absorption and mixtures thereof, and the weight of the total composition range and the peak absorption vary by organic molecule. AVobenzone from about 1% to about 5%, Ecamsule 1% to Different organic molecules have differences in how quickly about 10%, Octocrylene 0.5% to about 7%, Oxybenzone their absorption drops off (“fat curves as compared to 0.5% to about 6%, Octisalate 0.5% to about 6%, Sulisoben “skinny’ curves). Zone 0.5% to about 6%, Homosalate 0.5% to about 7% or 0015. It is important to realize that even within an organic Merdimate 0.5% to about 5% and mixtures thereof. molecule's absorption range, it does not absorb evenly and absorptions near the ends of the range are usually low. Sun DETAILED DESCRIPTION OF THE INVENTION screen manufacturers typically use several active ingredients 0022 Samples of vitamin D promoting sunscreen formu for screening different parts of the UV spectrum, thereby lations that were manufactured by the inventor in various providing protection from a broad spectrum of radiation.