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Chemical UVR Absorbers

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Chemical UVR Absorbers The names given in bold and used Diisopropyl methyl cinnamate Glyceryl ethyihexanoate dimethoxy- throughout this handbook are those of Empirical formula: cinnamate the International Nomenclature of C 6H22O2 Chemical names. Cosmetic Ingredients. Glyceryl octanoate dimethoxycinnamate; Chemical names: 2-propenoic acid, 3-(4-methoxyphenyl)-, 2-Propenoic acid, 3-12,4bis(1 diester with 1 ,3-dihydroxy-2-(2-ethyl-1 - methylethyphenyl-methyl ester; 2,5- oxohexyl)oxypropane diisopropyl methyl cinnamate _ lsoamyl-para-methoxycinnamate Ethyihexyl methoxycinnamate Empirical formula: Empirical formula: C151-12003 C 8H26O3 Chemical names: Cinnamates Chemical names: Amyl4-methoxycinnamate; isopentyl-4- 2-Ethylhexyl-4-methoxycin nam ate; methoxycinnamate; isopenlyl-para- Cinoxate 2-ethyl-hexyl-para-methoxycinnamate; methoxy-cinnamate; 3-(4-methoxyphenyl)- Empirical formula: para-methoxycinnamic acid, 2-ethylhexyl 2-propenoic acid, isopentyl ester Ci4HieO4 ester; 3-(4-methoxyphenyl)-2-propenoic acid, 2-ethylhexyl ester; octinoxate; octyl Trade names: Chemical names: methoxycinnamate; 2-propenoic acid, 3- Neo Heliopan type E 1000; Solarum AMC 2- Ethoxyothyl-para-methoxyci n nam ate; (4-methoxyphenyl)-2-ethylhexyl ester 2-propenoic acid, 3-(4-methoxyphery- para-A minobenzoic acids (PA BAs) 2-ethoxyethyl ester; 2-ethoxyethyl-4- Trade names: methoxycinnamate AEC Octyl Methoxycinnamate; Escalol Amyl dimethyl FABA 557; Eusolex 2292; Heliosol 3; Empirical formula: Trade names: Jeescreen OMC; Katoscreen OMC; Nec C14H21 NO2 Giv Tan F; Phiasol Heliopan, Type AV; Parsol MCX; Solarum OMC; Uvinul MC 80 Chemical names: DEA-methoxycinnamate Amyl para-N, N-dimethylaminobenzoate Empirical formula: Ethyl methoxycinnamate C14H21NO Empirical formula: Trade names: C12H1403 Escalol 506; Padimate A Chemical names: Diethanolamine salt of para-methoxyhy- Chemical names: Ethyl dihydroxypropyl PABA droxycinnamate; 2-propenoic acid, 3-(4- para-Methoxycinnamic acid, ethyl ester; Empirical formula: methoxyphenyl)-, conpd with 2,2'-imino- 3-(4-methoxyphenyl) -2-propenoic acid, C15H23N04 bis (ethanol) ethyl ester Trade name: Nipasorb D 175 IARC Handbooks of Cancer Prevention, Volume 5: Sunscreens Chemical names: PABA Chemical names: Benzoic acid, 4-[bis(2-hydroxypropyl)- Empirical formula: Benzoic acid, 2- hydroxy-2 -ethyl hexyl amino]ethyl ester (mixed isomers); ethyl- C7H7NO2 ester; 2-ethylbexyl 2-hydroxybenzoate; 4-bis(2-hyd roxypropyl)ami no ben zoate, 2-ethyihexyl salicylate; salicylic acid, 2- mixed isomers; ethyl dihydroxypropyl Chemical names. ethyihexyl ester; octisalate; octyl salicylate para-aminobenzoate, mixed isomers; N- Acid (PABA); aminobenzoic acid; 4- propoxylated-ethyl-4-aminobenzoate aminobenzoic acid; para-aminobenzoic Trade names: (mixed isomers) acid; aniline-4-carboxylic acid; benzoic Dermoblock (OS); Escall 587; Eusolex acid, 4-amino-; para-carboxyaniline; OS; Halibrite OS; Heliosol 2; Katoscreen Trade name: para-carboxyphenylamine OS; Neo Heliopan, Type OS; Neotan L; Amerscreen P Solarum OS; Sonnelan UV; Sunarome Trade names: WMO; Trivent OS; Uvinul 0-18 Ethyihexyl dimethyl PABA Amben; Pabacidum; Pabanol Empirical formula: Homosalate C17H27NO2 PEG-25 PABA Empirical formula: 1 Empirical formula: G16 ­12203 Chemical names: C59H111 N027 Benzoic acid, 4-(dimethylamino)-, 2-eth- Chemical names: ylhexyl ester; benzoic acid, 4-(dimethyl- Chemical names: Benzoic acid, 2-hydroxy- 3,3,5-trimethyl- amino)-, octyl ester; 4-(dimethyl- 4-Bis(poJyelhoxy)-4-amino.izoic acid cyclohexyl ester; cyclobexanol, 3,3,5- amino)benzoic acid, 2-ethyl-hexyl ester; polyethoxyethyl ester; ethoxylated ethyl- trimethyl salicylate; homomenthyl salicy- 2-etliylhexyl-4-(dimethylamino)benzoate; para-aminobenzoic acid; ethoxylated late; metahomomenthyl salicylate; 3,3,5- 2-ethyihexyl para-dimethylamino ben- ethyl-4-aminobenzoate trimethylcyclohexy 2-hydroxybenzoate; zoate; octyldimethyl PABA; octyl 3,3,5-trimethyl cyclohexyl salicylate dimethyl para-aminobenzoate Trade names: Lusantan 25; Uvinul P-25 Trade names: Trade names: Eusolex HMS; Filtrosol A; Heliopan; Arlatone UVB; Escalol 507; Eusolex Salicylates Uniderm HOMSAL 6007; Katoscreen ODMP; Padimate O; Sunarome PLUS; Uvasorb DM0 Dipropylene glycol salicylate lsopropylbenzyl salicylate Empirical formula: Empirical formula: Ethyl PABA CH1804 C1 H16O2 Empirical formula: C9H1 NO2 Chemical names: Chemical names: 2-Hydroxybenzoic acid dipropylene gly- 4-lsopropylbenzyl salicylate; 2-hydroxy- Chemical names: col ester; 2-(2-hydroxypropyl)-1 -methyl- benzoic acid 4-isopropylbenzyl ester Anesthesin; ethyl para-aminobenzoate ethyl salicylate Trade name: Glyceryl PABA Ethylene glycol salicylate Megasol Empirical formula: Empirical formula: C10H13N04 C9H1005 Methyl salicylate Empirical formula: Chemical names: Chemical names: C8H803 1 -(4-Am inobenzoate)-1 ,2,3-propanetriol; 2-Hydroxybenzoic acid ethylene glycol 4-aminobenzoic acid glyceryl ester; glyc- ester; 1 ,2-ethanediol salicylate Chemical names: eryl-para-amirobenzoate; glycerol 1-(4- Benzoic acid, 2-hydroxy-, methyl ester; aminobenzoate); PABA monoglyceride; Ethyihexyl salicylate betula oil; ortho-hydroxybenzoic acid, propanetriol 1 -(4-aminobenzoate) Empirical formula: methyl ester; 2-(methoxycarbonyl)phenol; C1 5H2203 methyl ortho-hydroxybenzoate; methyl 2- Trade name: hydroxybenzoate; oil of wintergreen; sali- Escalol 106 cylic acid, methyl ester; teaberry oil 1 76 Chemical UVR absorbers Phenyl salicylate Camphor benzalkonium methosulfate Ethyihexyl triazone Empirical formula: Chemical names: Empirical formula: C1 H10O3 Methyl-N,N,N-trimethyl-4-[(4,7,7-trmethyl- C49 H 96N90 3-oxobicyclo[2.2. 1 hept-2-ylidine) - Chemical name: methyl]anilinum sulfate; 3-(4'-trimethy- Chemical names: 2-Hydroxybenzoic acid phenyl ester ammonium berzylidene)-1-bornan -2- Octyl triazone; 2,4,6-tranilino-( para- one methyl sulfate; N,NNtri-mefhyl-4- carbo-2'-ethylhexyl- '-oxy)- 1,3,5 triazine Trade names: (2-oxoborn-3-ylidene methyl)-an] liniu m Salai; UVSAM-2142 methyl sulfate Trade name: Uvinul T-150 TEA salicylate Trade name: Empirical formula: Mexoryl SO 5-Methyl-2-phenylbenzoxazole C13H2106N Empirical formula: 4-Methylbenzylidene camphor C13H11N30 Chemical names: Empirical formula: Benzoic acid, 2-hydroxy-, compd with 01 8H 220 Chemical names: 2,2',2' -rlitrilotris[ethanol] (1:1); 2- 2-(2H-Benzotriol-2-yl)-para-cresol; 2-(2'- hydroxybenzoic acid, compd with Chemical names: hydroxy-5'-methylphenyl)benzotriazole 2,2 ,2"-nitrilotris[ethanol (1:1); trietha- 3-(4-Methylbenzylidene)borran-2-one; nolanine salicylate; trolamine salicylate 3-(4'-methylbenzylidene)-1 camphor; 1, Trade name: 7,7-trimethyl-3-(para-methylphenylmeth- Tinuvin P Trade names: ylene)-bicyclo[2.2.1 ] -heptane-2-one Katoscreen TES; Neo Heliopan, Type TS; Octocrylene Neotan W; Sunarome G; Sunarome W Trade names: Empirical formula: Eusolex 6300; Neo Heliopan, Type MBC; C24H27NO2 Camphor derivatives Parsol 5000; Solarum MBG; Uvinu MBC 95 Chemical names: 3-Benzylidene camphor 2-Cyano-3 ,3-diphenyl acrylic acid, 2-eth- Empirical formula: Polyacrylamidomethyl benzylidene ylhexyl ester; 2-ethylhexyl 2-cyaro-3 3- C17H190 camphor diphenylacrylate; 2-ethylhexyl 2-cyano- Chemical name: 3,3-diphenyl-2-propenoate; 2-ethylhexyl Chemical names: Polymer of N-(2 and 4)-[(2-oxoborn-3-yli- 2-cyano-3-phenylcinnamate; 2-propenoic 3-Benzylidenebornan-2-one; 1 ,7.7-trimethyl- done)methyl]benzyl]-acrylamide acid, 2-cyano-3,3-diphenyl-, 2-ethylhexyl 3-(phenylmethylene)bicylo-[2.2. 1 ]hep- ether tan-2-one Trade name: Mexoryl SW Trade names: Trade names: Escalol 597; Eusolex OCR; Nec Mexoryl SD; Ultracyd; Ultren BK Miscellaneous Heliopan, Type 303; Parsol 340; Solarum OCR; UV Absorber 3; Uvinul N-539T Benzylidene camphor sulfonic acid Diethythexylbutamido triazone Empirical formula: Chemical names: Phenylbenzimidazole sulfonic acid 1 Benzoic acid, 4,4'-[(-6-{[(1 ,1-dimethyl- Empirical formula: C17 ­1 1904 ethyl)-aminocarbonyl]-phenylamino}- C1 3H10N203S Chemical names: 1 ,3,5-triazine-2,4-diyl)-diimino]bis-, bis (2- c-(2-Oxoborn-3-ylidene)-foluene-4-sul- ethylhexyl) ether; dioctylbutamido triazone Chemical names: fonic acid; 3-(4 -sulfobenzylidene) camphor 2-Phenylbenzimidazol-5-sulfonic acid; 2- Trade name: phenyl-5-su lfobenzimidazole Trade name: Uvasorb HEB Mexoryl SL Trade names: Ensulizole; Eusolex 232; Neo Heliopan, Type Hydro; Novantisol; Parsol HS 177 ARC Handbooks of Cancer Prevention, Volume 5: Sunscreens Urocanic acid Benzophenone 3; Katoscreen B-3; Benzophenone-8 Empirical formula: Marsorb 24; Neo Heliopan, Type BB; Empirical formula: Protaphenone-3; Solarum B ZP3; C14H1204 C6H7N202 Spectra-Sorb UV-9; Syntase 82; Uvasorb MeT/C; Uvinul M-40; Uvistal 24 Chemical names: Chemical name: 2,2'-Dihydroxy-4-methoxybenzophenone; 3-(ImidazoI-4-yacryIic acid Benzophenone-4 dioxybenzone; (2-hydroxy-4-methoxy- Empirical formula: phenyl)(2-hydroxy-phenyl)-methanone; 014H 2068 methanone, (2-hydroxy-4-methoxy- phenyl) (2-hydroxyphenyl)- wil' Chemical names: Benzenesulfonic acid, 5-benzoyl-4- Trade name: Benzophenones hydroxy-2-methoxy-; 5-benzoyl-hydroxy-2- Spectra-Sorb UV-24 methcxybenzene-sulfonic acid; 5-benzoyl- Benzophenone-1 4-hydroxy-2-methoxybenzene sulfonic acid; Benzophenone-9 Empirical formula: 2-hydroxy-4-methoxybenzophenone-5- sul- Empirical formula: C13H1003 fonic acid; 1-phenol-4-sulfonic acid, 2-ben- C15H1201132.2Na zoyl-5-methoxy-; sulisobenzone Chemical names: Chemical names: Benzoresorcinol; 2,4-dihydroxybenzo Trade names: Disodium-3,3'-carbonylbis4-hydroxy-6- phenone Aduvex 112; Escalol 577; Jeescreen methoxybenzenesulfonate];
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    EWG Petitions CDC To Conduct Biomonitoring Studies for Common Sunscreen Chemicals May 22, 2019 To: U.S. Department of Health and Human Services Centers for Disease Control and Prevention National Center for Environmental Health Agency for Toxic Substances and Disease Registry 4770 Buford Hwy, NE Atlanta, GA 30341 Patrick Breysse, Ph.D., CIH Environmental Working Group (EWG), a nonprofit research and advocacy organization with headquarters in Washington, D.C., is petitioning the Centers for Disease Control and Prevention to add common sunscreen chemicals to the CDC’s Biomonitoring Program. EWG has been doing research on sunscreen ingredients since 2007, helping to educate the public about the importance of using sunscreens for health protection, as well as providing information about health risks that may be associated with certain ingredients used in sunscreen products. In response to a significant increase in the use of sunscreens in the United States and the associated increased potential for systemic exposure to the ingredients in these products, in February 2019, the Food and Drug Administration proposed a new rule for sunscreen products.1 The proposed rule would require sunscreen active ingredients to be assessed for their propensity to absorb through the skin and overall safety. Recently, the FDA completed tests on the absorbance of four common sunscreen active ingredients: avobenzone, oxybenzone, octocrylene, and ecamsule. As reported in a study published by the Journal of American Medical Association in May 2019,2 application of all four tested sunscreen ingredients resulted in plasma concentrations that exceeded the 0.5 ng/mL threshold proposed by the FDA for waiving systemic carcinogenicity studies as well as developmental and reproductive toxicity studies.
  • Sun Protection

    Sun Protection

    [ Oncology Watch] Sun Protection: What We and Our Patients Need to Know To preserve their health and the appearance of their skin, patients need straight- forward, practical advice on susncreen selection and protection strategies. By Jonathan Wolfe, MD rom preventing skin cancer to pre- measures protection against cutaneous burning. Even a FDA public education serving a youthful appearance, burning—the effects of UVB—and does piece states, “A higher number means it Fsunscreens play an important role not account for UVA radiation at all.5 As protects longer.”7 This is not a strictly in dermatologic care. However, some a result, a product with a high SPF could accurate interpretation of the SPF value confusion persists among patients and actually confer little or no protection and ignores the fact that unique proper- even some practitioners when it comes to against UVA. ties of the main sunscreen ingredients SPF, available chemical and physical sun- The somewhat esoteric description of (chemical or physical) and the formula- screens, and the best advice for sun SPF calculation is available online at the tion (waterproof, water resistant) influ- avoidance. In recognition of the AAD’s FDA website.6 Ultimately, the SPF num- ence duration of protection. Skin Cancer Detection and Prevention ber represents the ratio of the MED for Patients also often falsely assume that Month, I’ll review important patient protected skin (MED(PS)) to the MED the increase in SPF value is proportion- education points. for unprotected skin (MED(US)). Tests ate to the increase in UVB protection. It are conducted only in patients with skin is not.