Chemical UVR Absorbers

The names given in bold and used Diisopropyl methyl cinnamate Glyceryl ethyihexanoate dimethoxy- throughout this handbook are those of Empirical formula: cinnamate the International Nomenclature of C 6H22O2 Chemical names. Cosmetic Ingredients. Glyceryl octanoate dimethoxycinnamate; Chemical names: 2-propenoic acid, 3-(4-methoxyphenyl)-, 2-Propenoic acid, 3-12,4bis(1 diester with 1 ,3-dihydroxy-2-(2-ethyl-1 - methylethyphenyl-methyl ester; 2,5- oxohexyl)oxypropane diisopropyl methyl cinnamate _ lsoamyl-para-methoxycinnamate Ethyihexyl methoxycinnamate Empirical formula: Empirical formula: C151-12003 C 8H26O3 Chemical names: Cinnamates Chemical names: Amyl4-methoxycinnamate; isopentyl-4- 2-Ethylhexyl-4-methoxycin nam ate; methoxycinnamate; isopenlyl-para- 2-ethyl-hexyl-para-methoxycinnamate; methoxy-cinnamate; 3-(4-methoxyphenyl)- Empirical formula: para-methoxycinnamic acid, 2-ethylhexyl 2-propenoic acid, isopentyl ester Ci4HieO4 ester; 3-(4-methoxyphenyl)-2-propenoic acid, 2-ethylhexyl ester; octinoxate; octyl Trade names: Chemical names: methoxycinnamate; 2-propenoic acid, 3- Neo Heliopan type E 1000; Solarum AMC 2- Ethoxyothyl-para-methoxyci n nam ate; (4-methoxyphenyl)-2-ethylhexyl ester 2-propenoic acid, 3-(4-methoxyphery- para-A minobenzoic acids (PA BAs) 2-ethoxyethyl ester; 2-ethoxyethyl-4- Trade names: methoxycinnamate AEC ; Escalol Amyl dimethyl FABA 557; Eusolex 2292; Heliosol 3; Empirical formula: Trade names: Jeescreen OMC; Katoscreen OMC; Nec C14H21 NO2 Giv Tan F; Phiasol Heliopan, Type AV; Parsol MCX; Solarum OMC; Uvinul MC 80 Chemical names: DEA-methoxycinnamate Amyl para-N, N-dimethylaminobenzoate Empirical formula: Ethyl methoxycinnamate C14H21NO Empirical formula: Trade names: C12H1403 Escalol 506; Padimate A Chemical names: Diethanolamine salt of para-methoxyhy- Chemical names: Ethyl dihydroxypropyl PABA droxycinnamate; 2-propenoic acid, 3-(4- para-Methoxycinnamic acid, ethyl ester; Empirical formula: methoxyphenyl)-, conpd with 2,2'-imino- 3-(4-methoxyphenyl) -2-propenoic acid, C15H23N04 bis () ethyl ester

Trade name: Nipasorb D

175 IARC Handbooks of Cancer Prevention, Volume 5:

Chemical names: PABA Chemical names: Benzoic acid, 4-[bis(2-hydroxypropyl)- Empirical formula: Benzoic acid, 2- hydroxy-2 -ethyl hexyl amino]ethyl ester (mixed isomers); ethyl- C7H7NO2 ester; 2-ethylbexyl 2-hydroxybenzoate; 4-bis(2-hyd roxypropyl)ami no ben zoate, 2-ethyihexyl salicylate; , 2- mixed isomers; ethyl dihydroxypropyl Chemical names. ethyihexyl ester; octisalate; para-aminobenzoate, mixed isomers; N- Acid (PABA); aminobenzoic acid; 4- propoxylated-ethyl-4-aminobenzoate aminobenzoic acid; para-aminobenzoic Trade names: (mixed isomers) acid; aniline-4-carboxylic acid; benzoic Dermoblock (OS); Escall 587; Eusolex acid, 4-amino-; para-carboxyaniline; OS; Halibrite OS; Heliosol 2; Katoscreen Trade name: para-carboxyphenylamine OS; Neo Heliopan, Type OS; Neotan L; Amerscreen P Solarum OS; Sonnelan UV; Sunarome Trade names: WMO; Trivent OS; Uvinul 0-18 Ethyihexyl dimethyl PABA Amben; Pabacidum; Pabanol Empirical formula: C17H27NO2 PEG-25 PABA Empirical formula: 1 Empirical formula: G16 ­12203 Chemical names: C59H111 N027 Benzoic acid, 4-(dimethylamino)-, 2-eth- Chemical names: ylhexyl ester; benzoic acid, 4-(dimethyl- Chemical names: Benzoic acid, 2-hydroxy- 3,3,5-trimethyl- amino)-, octyl ester; 4-(dimethyl- 4-Bis(poJyelhoxy)-4-amino.izoic acid cyclohexyl ester; cyclobexanol, 3,3,5- amino)benzoic acid, 2-ethyl-hexyl ester; polyethoxyethyl ester; ethoxylated ethyl- trimethyl salicylate; homomenthyl salicy- 2-etliylhexyl-4-(dimethylamino)benzoate; para-aminobenzoic acid; ethoxylated late; metahomomenthyl salicylate; 3,3,5- 2-ethyihexyl para-dimethylamino ben- ethyl-4-aminobenzoate trimethylcyclohexy 2-hydroxybenzoate; zoate; octyldimethyl PABA; octyl 3,3,5-trimethyl cyclohexyl salicylate dimethyl para-aminobenzoate Trade names: Lusantan 25; Uvinul P-25 Trade names: Trade names: Eusolex HMS; Filtrosol A; Heliopan; Arlatone UVB; Escalol 507; Eusolex Salicylates Uniderm HOMSAL 6007; Katoscreen ODMP; ; Sunarome PLUS; Uvasorb DM0 Dipropylene glycol salicylate lsopropylbenzyl salicylate Empirical formula: Empirical formula: Ethyl PABA CH1804 C1 H16O2 Empirical formula: C9H1 NO2 Chemical names: Chemical names: 2-Hydroxybenzoic acid dipropylene gly- 4-lsopropylbenzyl salicylate; 2-hydroxy- Chemical names: col ester; 2-(2-hydroxypropyl)-1 -methyl- benzoic acid 4-isopropylbenzyl ester Anesthesin; ethyl para-aminobenzoate Trade name: Glyceryl PABA Ethylene glycol salicylate Megasol Empirical formula: Empirical formula: C10H13N04 C9H1005 Empirical formula: Chemical names: Chemical names: C8H803 1 -(4-Am inobenzoate)-1 ,2,3-propanetriol; 2-Hydroxybenzoic acid ethylene glycol 4-aminobenzoic acid glyceryl ester; glyc- ester; 1 ,2-ethanediol salicylate Chemical names: eryl-para-amirobenzoate; glycerol 1-(4- Benzoic acid, 2-hydroxy-, methyl ester; aminobenzoate); PABA monoglyceride; Ethyihexyl salicylate betula oil; ortho-hydroxybenzoic acid, propanetriol 1 -(4-aminobenzoate) Empirical formula: methyl ester; 2-(methoxycarbonyl)phenol; C1 5H2203 methyl ortho-hydroxybenzoate; methyl 2- Trade name: hydroxybenzoate; oil of wintergreen; sali- Escalol 106 cylic acid, methyl ester; teaberry oil

1 76 Chemical UVR absorbers

Phenyl salicylate Camphor benzalkonium methosulfate Ethyihexyl triazone Empirical formula: Chemical names: Empirical formula: C1 H10O3 Methyl-N,N,N-trimethyl-4-[(4,7,7-trmethyl- C49 H 96N90 3-oxobicyclo[2.2. 1 hept-2-ylidine) - Chemical name: methyl]anilinum sulfate; 3-(4'-trimethy- Chemical names: 2-Hydroxybenzoic acid phenyl ester ammonium berzylidene)-1-bornan -2- Octyl triazone; 2,4,6-tranilino-( para- one methyl sulfate; N,NNtri-mefhyl-4- carbo-2'-ethylhexyl- '-oxy)- 1,3,5 triazine Trade names: (2-oxoborn-3-ylidene methyl)-an] liniu m Salai; UVSAM-2142 methyl sulfate Trade name: Uvinul T-150 TEA salicylate Trade name: Empirical formula: Mexoryl SO 5-Methyl-2-phenylbenzoxazole C13H2106N Empirical formula: 4-Methylbenzylidene camphor C13H11N30 Chemical names: Empirical formula: Benzoic acid, 2-hydroxy-, compd with 01 8H 220 Chemical names: 2,2',2' -rlitrilotris[ethanol] (1:1); 2- 2-(2H-Benzotriol-2-yl)-para-cresol; 2-(2'- hydroxybenzoic acid, compd with Chemical names: hydroxy-5'-methylphenyl)benzotriazole 2,2 ,2"-nitrilotris[ethanol (1:1); trietha- 3-(4-Methylbenzylidene)borran-2-one; nolanine salicylate; 3-(4'-methylbenzylidene)-1 camphor; 1, Trade name: 7,7-trimethyl-3-(para-methylphenylmeth- Tinuvin P Trade names: ylene)-bicyclo[2.2.1 ] -heptane-2-one Katoscreen TES; Neo Heliopan, Type TS; Neotan W; Sunarome G; Sunarome W Trade names: Empirical formula: Eusolex 6300; Neo Heliopan, Type MBC; C24H27NO2 Camphor derivatives Parsol 5000; Solarum MBG; Uvinu MBC 95 Chemical names: 3-Benzylidene camphor 2-Cyano-3 ,3-diphenyl acrylic acid, 2-eth- Empirical formula: Polyacrylamidomethyl benzylidene ylhexyl ester; 2-ethylhexyl 2-cyaro-3 3- C17H190 camphor diphenylacrylate; 2-ethylhexyl 2-cyano- Chemical name: 3,3-diphenyl-2-propenoate; 2-ethylhexyl Chemical names: Polymer of N-(2 and 4)-[(2-oxoborn-3-yli- 2-cyano-3-phenylcinnamate; 2-propenoic 3-Benzylidenebornan-2-one; 1 ,7.7-trimethyl- done)methyl]benzyl]-acrylamide acid, 2-cyano-3,3-diphenyl-, 2-ethylhexyl 3-(phenylmethylene)bicylo-[2.2. 1 ]hep- ether tan-2-one Trade name: Mexoryl SW Trade names: Trade names: Escalol 597; Eusolex OCR; Nec Mexoryl SD; Ultracyd; Ultren BK Miscellaneous Heliopan, Type 303; Parsol 340; Solarum OCR; UV Absorber 3; Uvinul N-539T Benzylidene camphor sulfonic acid Diethythexylbutamido triazone Empirical formula: Chemical names: Phenylbenzimidazole sulfonic acid 1 Benzoic acid, 4,4'-[(-6-{[(1 ,1-dimethyl- Empirical formula: C17 ­1 1904 ethyl)-aminocarbonyl]-phenylamino}- C1 3H10N203S Chemical names: 1 ,3,5-triazine-2,4-diyl)-diimino]bis-, bis (2- c-(2-Oxoborn-3-ylidene)-foluene-4-sul- ethylhexyl) ether; dioctylbutamido triazone Chemical names: fonic acid; 3-(4 -sulfobenzylidene) camphor 2-Phenylbenzimidazol-5-sulfonic acid; 2- Trade name: phenyl-5-su lfobenzimidazole Trade name: Uvasorb HEB Mexoryl SL Trade names: ; Eusolex 232; Neo Heliopan, Type Hydro; Novantisol; Parsol HS

177 ARC Handbooks of Cancer Prevention, Volume 5: Sunscreens

Urocanic acid 3; Katoscreen B-3; Benzophenone-8 Empirical formula: Marsorb 24; Neo Heliopan, Type BB; Empirical formula: Protaphenone-3; Solarum B ZP3; C14H1204 C6H7N202 Spectra-Sorb UV-9; Syntase 82; Uvasorb MeT/C; Uvinul M-40; Uvistal 24 Chemical names: Chemical name: 2,2'-Dihydroxy-4-methoxybenzophenone; 3-(ImidazoI-4-yacryIic acid Benzophenone-4 ; (2-hydroxy-4-methoxy- Empirical formula: phenyl)(2-hydroxy-phenyl)-methanone; 014H 2068 methanone, (2-hydroxy-4-methoxy- phenyl) (2-hydroxyphenyl)- wil' Chemical names: Benzenesulfonic acid, 5-benzoyl-4- Trade name: hydroxy-2-methoxy-; 5-benzoyl-hydroxy-2- Spectra-Sorb UV-24 methcxybenzene-sulfonic acid; 5-benzoyl- Benzophenone-1 4-hydroxy-2-methoxybenzene sulfonic acid; Benzophenone-9 Empirical formula: 2-hydroxy-4-methoxybenzophenone-5- sul- Empirical formula: C13H1003 fonic acid; 1-phenol-4-sulfonic acid, 2-ben- C15H1201132.2Na zoyl-5-methoxy-; Chemical names: Chemical names: Benzoresorcinol; 2,4-dihydroxybenzo Trade names: Disodium-3,3'-carbonylbis4-hydroxy-6- phenone Aduvex 112; Escalol 577; Jeescreen methoxybenzenesulfonate]; sodium 2,2'- Benzophenone 4; Potaphenone-4: dihyd roxy-4 ,4'-d in ethoxy-5-suIf obe n- Trade names: Syntase 230; Uval; Uvasorb S5; Uvinul zophenone ASL-23; Syntase 100; Uvasorb 20H/G; MS-40; IJvistat 112 Uvinul 400; UVSAM-214 Trade name: Benzophenone-5 Uvinul DS-49 Benzophenone-2 Empirical formula: Empirical formula: C14H1206S.Na Benzophenone-10 C 3H10O5 Empirical formula: Chemical names: C 51-11403 Chemical names: Benzenesulfonic acid, 5-benzoyl-4- Bis(2,4-dhydroxyphenyI) methanone; hydroxy-2-methoxy-, monosodium salt; Chemical names: 2,2',4,4'-tetrahydroxybenzophenone sodium 2-hydroxy-4-methoxy-5-sulfoben- 2-Hydroxy-4-methoxy-4'-methylbenzo- zophenone; benzophenone-4 sodium salt phenone; (2-hydroxy-4-methoxyphenyl)- Trade name: (4-methylpheny-methanone Uvinul D-50 Trade name: ASL-24S Trade names: Benzophenone-3 Aduvex 2211; ; Uvistat 2211 Empirical formula: Benzophenone-6 C14H1203 Empirical formula: Camphor derivatives C15H1405 Chemical names: Terephthalylidene dicamphor 2-Benzyl-5-methoxyphenol; 2-hydroxy- Chemical names: sulfonic acid 4-methoxybenzophenone; (2-hydroxy-4- Bis(2-hydroxy-4-methoxyphenyl) me- Empirical formula: methoxyphenyl)phenylmethanone; metha- thanone; 22'-dihydroxy-4,4'-dimethoxy- C25H34O8S2 none (2-hydroxy-4-methoxphenyl)phenyI; benzophenone Chemical names: Trade name: 3,3-(1 ,4-Phenylenedimethylene)bis(7,7- Trade names: Uvinul D-49 dimethyl-2-oxo-bicyclo[2.2.1]hept-1 -yl- ASL 24; Cyasorb UV-9; Escalol 567; methanesulfonic) acid Eusolex 4360; EUSORB 228; Jeescreen

178 Chemical UVR absorbers

Trade names: Micro T; Micro MT- ; Mexoryl SX 500B; Micro Titanium Dioxide MT-I 50W; MTD-25; NanoGard AQ; Nana TZ; Dibenzoy!methanes Oxyde de Titane Organophile W 877; Miscellaneous Oxyde de Titane Standard; P25; Sicovit Butyl methoxydibenzoylmethane White E 171; SI-UF20-Z; SI-UFTR-Z; Empirical formula: Anisotriazine Spherititan; T102 09228 Blend; Ti02 C20H2203 Chemical name: D13; Ti-Sphere AA-1515; Ti-Sphere AA- 2,4-Bis[4-(2-ethylhexyloxy)-2-hydroxyl]- 1512-LL; Titanium Dioxide P 25; Titanium Chemical names: pheryl-6-(4-methoxyphenyl)-tetramethyl- Dioxide 10-34-PC-0082; Titanium Dioxide ; 4-tert-butyl-4'-methoxydiben- butyl)-phenol (1 ,3,5)-triazine 10-34-PC-0748; Titanium Dioxide, USP, zoylmethane; 1 -(4-tert-butylphenyl-3-(4- CTFA, Bacteria Controlled; UF-20; methoxyphenyl)propane-1 ,3-dione; 1-[4- UFTR; Uniwhite AO; Uniwhite KO; UV- (1,1 -dimethyIethyI)phenyI -3-(4-methoxy- Chemical name: Titan phenyl)-1 ,3-propanedione; 1,3-propane- Phenol, 2-(2H-benzotriazol-2-y-4-methyl- dione, 2-butyl-2-niethoxy-1 ,3-diphenyl-; 6-[2-m ethyl -3-[1 ,3,3,3-tetramethyl-1 -(tri- 1 ,3-propanedione, 1-[4-(1,1 -dimethyl- methylsilyl)oxy]disil-oxanyl)propyl Empirical formula: ethyphenyI]-3-(4-methoxyphenyl) ZnO Trade name: Trade names: Mexoryl XL Chemical names: Eusolex 9020; Neo Heliopan, Type MA; Low temperature burned zinc oxide; pig- Parsol 1789; Parsol A; Solarum BMBM; Methylene bisbenzotriazolyl tetra- ment white 4; zinc white Solarum MA methylbutylphenol Chemical names. Trade names: Anthranilates 2,2'-Methylene-bis-6-(2H-benzotriazol-2- Cl 77947; Finex-25; MZO-25; NanoGard yl)-4-( 1,1 ,3,3-ietramethylbutyl)phenol Zinc Oxide; Nano-TZ; Nanox; Nano-Zinc SL; Oxyde de Zinc Micropure; Unichem Empirical formula: ZO; USP 1; USP-2; Z-Cote; Zinc Oxide C17H25NO2 Neutral H&R (PN 104 702); Zinc Oxide USP 66 Chemical names: Cyclohexanol, 5-methyl-2-(l -methyl- Titanium dioxide ethyl) -2 -am inobe nzoate; menthyl-ortho- Empirical formula: aminobenzoate; meradimate Ti02

Trade names: Chemical names: Neo Heliopar MA; Trivent MA Amorphous titanium dioxide; micro parti- cle titanium dioxide; pigment white 6; titanium dioxide sol; titanium oxide Miscellaneous Trade names: Bisymidazylate A31 O Tudor Aspen; Atlas White Titanium Chemical name: Dioxide 09985; 047-5175 Cosmetic 2,2'-Bis(1 ,4-phenylene)-1 H-benzimida- White; Cl 77891; Kowet Titanium Dioxide zoIe-4,6-disuIonic acid, monosodium salt 09970; Kronos 1025; KIRONOS 2071-U;

179 Appendix 2 Definition of genetic test codes

End-Pointa Gode Definition

Non-mammalian systems Prokaryotic systems G SAC Salmonella typhimurium TA1 00, reverse mutation G SA2 Salmonella typhimurium TA1 02, reverse mutation G SA5 Salmonella typhimurium TAI 535, reverse mutation G SA7 Salmonella typhimurium TA1537, reverse mutation G SA8 Salmonella typhimurium TA1 538, reverse mutation G SA9 Salmonella typhimurium TA98, reverse mutation G ECW Escherichia cell WP2 uvrA, reverse mutation G EC2 Escherichia co/i WP2, reverse mutation

Lower eukaryotic systems D SSD Saccharomyces species, DNA repair-deficient strains, differential toxicity R SCG Saccharomyces cern visiae, gene conversion G SCR Saccharomyces core visiae, reverse mutation

Insect systems G DMM Drosophila melanogaster, somatic mutation G DMX Drosophila melanogaster, sex-linked recessive lethal mutations

Mammalian systems Animal ce/Is in vitro G G5T Gene mutatron, mouse lymphoma L5178Y cells, Tklocus G G51 Gene mutation, mouse lymphoma L5178Y cells, all other loci S 81G Sister chromatid exchange, Chinese hamster cells in vitro G GIG Chromosomal aberrations, Chinese hamster cells in vitro

Human cells in vitro D DIH DNA strand breaks, cross-links or related damage, human cells in vitro

Animals in vivo M MVR Micronucleus formation, rats in vivo G CBA Chromosomal aberrations, animal bore-marrow cells in vivo

Endpoints are grouped within each phylogenetic category as follows: C, chromosomal aberrations; D, DNA damage; G, gene mutation; M, micronuclei; R, mitotic recombination or gene conversion; S, sister chromatid exchange