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  • Supporting Materials for Reappointment of Rong Di for 2004
    CURRICULUM VITAE Rong Di Associate Research Professor Department of Plant Biology School of Environmental and Biological Sciences Rutgers University 222B Foran Hall, 59 Dudley Rd., New Brunswick, NJ 08901 Ph. (848)-932-6350, Fax (732)-932-9377 [email protected] http://plantbiology.rutgers.edu/faculty/di/Rong_Di.html July 2017 Appointments 2017-Present Associate Research Professor, Department of Plant Biology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 2011-2017 Assistant Research Professor, Department of Plant Biology and Pathology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 2014-Present Adjunct Professor, Hainan University, Hainan, China 2003-2011 Assistant Research Professor, Biotechnology Center for Agriculture and the Environment, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 1997- 2002 Research Associate, Biotechnology Center for Agriculture and the Environment, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 1992-1996 Postdoctoral Scholar, Dept. of Plant Pathology, and Dept. of Agronomy, University of Kentucky, Lexington, KY 1986-1992 Graduate Research Assistant, Dept. of Plant Pathology, Iowa State University, Ames, IA 1983-1985 Assistant Lecturer, Dept. of Plant Protection, South China College of Tropical Crops (SCCTC), Hainan, P. R. China Education Ph.D. 1992 Plant Virology, Iowa State University, Iowa (Advisor: W Allen Miller) M.S. 1989 Plant Virology, Iowa State University, Iowa (Advisor: John Hill) B.S. 1983 Plant Protection, South China College of Tropical Crops, Hainan, P.R. China Honors and Awards 1985 Selected as the only one among 45 graduates in the Dept. of Plant Protection from SCCTC China to study abroad.
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  • Natural Skin‑Whitening Compounds for the Treatment of Melanogenesis (Review)
    EXPERIMENTAL AND THERAPEUTIC MEDICINE 20: 173-185, 2020 Natural skin‑whitening compounds for the treatment of melanogenesis (Review) WENHUI QIAN1,2, WENYA LIU1, DONG ZHU2, YANLI CAO1, ANFU TANG1, GUANGMING GONG1 and HUA SU1 1Department of Pharmaceutics, Jinling Hospital, Nanjing University School of Medicine; 2School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210002, P.R. China Received June 14, 2019; Accepted March 17, 2020 DOI: 10.3892/etm.2020.8687 Abstract. Melanogenesis is the process for the production of skin-whitening agents, boosted by markets in Asian countries, melanin, which is the primary cause of human skin pigmenta- especially those in China, India and Japan, is increasing tion. Skin-whitening agents are commercially available for annually (1). Skin color is influenced by a number of intrinsic those who wish to have a lighter skin complexions. To date, factors, including skin types and genetic background, and although numerous natural compounds have been proposed extrinsic factors, including the degree of sunlight exposure to alleviate hyperpigmentation, insufficient attention has and environmental pollution (2-4). Skin color is determined by been focused on potential natural skin-whitening agents and the quantity of melanosomes and their extent of dispersion in their mechanism of action from the perspective of compound the skin (5). Under physiological conditions, pigmentation can classification. In the present article, the synthetic process of protect the skin against harmful UV injury. However, exces- melanogenesis and associated core signaling pathways are sive generation of melanin can result in extensive aesthetic summarized. An overview of the list of natural skin-lightening problems, including melasma, pigmentation of ephelides and agents, along with their compound classifications, is also post‑inflammatory hyperpigmentation (1,6).
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  • Comparison of the Effect of Oestrogen Plus Foeniculum Vulgare Seed and Oestrogen Alone on Increase in Endometrial Thickness in I
    DOI: 10.7860/JCDR/2018/30164.11020 Original Article Comparison of the Effect of Oestrogen Plus Foeniculum vulgare Section Seed and Oestrogen alone on Obstetrics and Gynaecology Increase in Endometrial Thickness in Infertile Women MAHNAZ YAVANGI1, SOGHRA RABIEE2, SARA NAZARI3, MARZIEH FARIMANI-SANOEE4, IRAJ AMIRI5, MARYAM BAHMANZADEH6, SAEID HEIDARI-SOURESHJANI7 ABSTRACT β-hCG level and increase in oestrogen dose were recorded in Introduction: Foeniculum vulgare seed is used to treat infertility a checklist. The data were analysed by independent t-test and because of phytoestrogenic properties. Chi-square in SPSS version 17.0. Aim: The present study was conducted to compare the effects Results: There were no significant differences in mean age, of F. vulgare plus oestrogen and oestrogen alone on Endometrial BMI, number of years of infertility, number of children, cause Thickness (ET) in infertile women. of infertility, positive β-hCG, failure to achieve adequate endometrial thickness, and increase in oestradiol dose between Materials and Methods: In this study, 92 people with infertility the treatment and control groups (p>0.05). The mean number were enrolled by convenience sampling and randomly divided of days to achieve ET of at least 8 mm was 13.1±3.2 in the into treatment case (45 women) and control (47 women) groups. treatment group and 14.2±3.5 in the control group with no Both groups were administered with oestradiol valerate 2 mg significant difference (p>0.05). tablet three times a day since the third day of the menstrual cycle. Treatment group was also administered with F. vulgare Conclusion: F.
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  • Improvement of Resveratrol Permeation Through
    pharmaceutics Article Improvement of Resveratrol Permeation through Sublingual Mucosa: Chemical Permeation Enhancers versus Spray Drying Technique to Obtain Fast-Disintegrating Sublingual Mini-Tablets Giulia Di Prima 1,* , Giuseppe Angellotti 1,2 , Amalia Giulia Scarpaci 1, Denise Murgia 1 , Fabio D’agostino 3 , Giuseppina Campisi 2 and Viviana De Caro 1 1 Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), University of Palermo, Via Archirafi 32, 90123 Palermo, Italy; [email protected] (G.A.); [email protected] (A.G.S.); [email protected] (D.M.); [email protected] (V.D.C.) 2 Dipartimento di Discipline Chirurgiche, Oncologiche e Stomatologiche, Università degli Studi di Palermo, 90127 Palermo, Italy; [email protected] 3 Istituto per lo Studio degli Impatti Antropici e Sostenibilità dell’Ambiente Marino, Consiglio Nazionale delle Ricerche (IAS—CNR), Campobello di Mazara, 91021 Trapani, Italy; [email protected] * Correspondence: [email protected] Abstract: Resveratrol (RSV) is a natural polyphenol with several interesting broad-spectrum pharma- cological properties. However, it is characterized by poor oral bioavailability, extensive first-pass Citation: Di Prima, G.; Angellotti, G.; effect metabolism and low stability. Indeed, RSV could benefit from the advantage of the sublingual Scarpaci, A.G.; Murgia, D.; route of administration. In this view, RSV attitudes to crossing the porcine sublingual mucosa were D’agostino, F.; Campisi, G.; De Caro, evaluated and promoted both by six different chemical permeation enhancers (CPEs) as well as V. Improvement of Resveratrol Permeation through Sublingual by preparing four innovative fast-disintegrating sublingual mini-tablets by spray drying followed Mucosa: Chemical Permeation by direct compression.
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  • Chemical Structures of Lignans and Neolignans Isolated from Lauraceae
    Review Chemical Structures of Lignans and Neolignans Isolated from Lauraceae Ya Li 1,*, Shuhan Xie 2, Jinchuan Ying 1, Wenjun Wei 1 and Kun Gao 1,* 1 State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China; [email protected] (J.Y.); [email protected] (W.W.) 2 Lanzhou University High School, Lanzhou 730000, China; [email protected] * Correspondences: [email protected] (Y.L.); [email protected] (K.G.); Tel.: +86-931-8912500 (Y.L.) Academic Editor: David Barker Received: 09 November 2018; Accepted: 29 November 2018; Published: 30 November 2018 Abstract: Lauraceae is a good source of lignans and neolignans, which are the most chemotaxonomic characteristics of many species of the family. This review describes 270 naturally occurring lignans and neolignans isolated from Lauraceae. Keywords: lignans; neolignans; Lauraceae; chemical components; chemical structures 1. Introduction Lignans are widely distributed in the plant kingdom, and show diverse pharmacological properties and a great number of structural possibilities. The Lauraceae family, especially the genera of Machilus, Ocotea, and Nectandra, is a rich source of lignans and neolignans, and neolignans represent potential chemotaxonomic significance in the study of the Lauraceae. Lignans and neolignans are dimers of phenylpropane, and conventionally classified into three classes: lignans, neolignans, and oxyneolignans, based on the character of the C–C bond and oxygen bridge joining the two typical phenyl propane units that make up their general structures [1]. Usually, lignans show dimeric structures formed by a β,β’-linkage (8,8’-linkage) between two phenylpropanes units. Meanwhile, the two phenylpropanes units are connected through a carbon–carbon bond, except for the 8,8’-linkage, which gives rise to neolignans.
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  • Selective Estrogen Receptor Modulators for BPH: New Factors on the Ground
    Prostate Cancer and Prostatic Disease (2013) 16, 226–232 & 2013 Macmillan Publishers Limited All rights reserved 1365-7852/13 www.nature.com/pcan REVIEW Selective estrogen receptor modulators for BPH: new factors on the ground M Garg1, D Dalela1, D Dalela1, A Goel1, M Kumar1, G Gupta2 and SN Sankhwar1 As the current management of BPH/lower urinary tract symptoms by traditionally involved pharmacological agents such as 5alpha- reductase inhibitors and a1-adrenoceptor antagonists is suboptimal, there is definite need of new therapeutic strategies. There is ample evidence in literature that suggests the role of estrogens in BPH development and management through the different tissue and cell-specific receptors. This article reviews the beneficial actions of selective estrogen receptor modulator (SERM) and ERb- selective ligands, which have been demonstrated through in vitro studies using human prostate cell lines and in vivo animal studies. SERMs have anti-proliferative, anti-inflammatory and pro-apoptotic mechanisms in BPH, and also act by inhibiting various growth factors, and thus represent a unique and novel approach in BPH management directed at estrogen receptors or estrogen metabolism. Prostate Cancer and Prostatic Disease (2013) 16, 226–232; doi:10.1038/pcan.2013.17; published online 18 June 2013 Keywords: selective estrogen receptors modulators; BPH; estradiol; estrogen receptor b INTRODUCTION relevant articles were selected for the discussion of role of SERMs in BPH in BPH is a common urological problem of aging males. It occurs in this review. about 10% of men below the age of 40 and increases to about 80% by 80 years of age.1 Clinical BPH is a benign enlargement of the prostate, which ESTROGENS AND ITS RECEPTORS: ROLE IN BPH results in voiding urinary difficulties that may, sometimes, Though BPH typically manifests in later stage of life when 2 significantly impair the quality of life in older patients.
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  • Redalyc.Chemical Constituents from Zanthoxylum Setulosum (Rutaceae)
    Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas ISSN: 0717-7917 [email protected] Universidad de Santiago de Chile Chile MORA, Soledad; CASTRO, Víctor; POVEDA, Luis; CHAVARRÍA, Max; MURILLO, Renato Chemical constituents from Zanthoxylum setulosum (Rutaceae) Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, vol. 10, núm. 2, marzo, 2011, pp. 155-158 Universidad de Santiago de Chile Santiago, Chile Available in: http://www.redalyc.org/articulo.oa?id=85617384009 How to cite Complete issue Scientific Information System More information about this article Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Journal's homepage in redalyc.org Non-profit academic project, developed under the open access initiative © 2011 The Authors © 2011 Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas 10 (2): 155 - 158 BLACPMA ISSN 0717 7917 Artículo Original | Original Article Chemical constituents from Zanthoxylum setulosum (Rutaceae) [Costituyentes químicos de Zanthoxylum setulosum (Rutaceae)] Soledad MORA1, Víctor CASTRO1, Luis POVEDA2, Max CHAVARRÍA1 & Renato MURILLO1 1Escuela de Química and CIPRONA, Universidad de Costa Rica, 2060, San José, Costa Rica. 2Escuela de Ciencias Ambientales, Facultad de Ciencias de la Tierra y el Mar, Universidad Nacional, 3000, Costa Rica. Contactos | Contacts: Max CHAVARRIA E-mail address [email protected] Abstract Following our phytochemical studies of Costa Rican plants, in this work we report the isolation and identification of eight compounds from aerial parts of Zanthoxylum setulosum (Rutaceae). They were identified as the alkaloid skimmianine, the lignans savinin, kusunokinin, sesamin, syringaresinol and the isopentenyl ether of pluviatol, the amide aurantiamide acetate, and the triterpen lupeol.
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  • Understanding and Managing the Transition Using Essential Oils Vs
    MENOPAUSE: UNDERSTANDING AND MANAGING THE TRANSITION USING ESSENTIAL OILS VS. TRADITIONAL ALLOPATHIC MEDICINE by Melissa A. Clanton A thesis submitted in partial fulfillment of the requirements for the Diploma of Aromatherapy 401 Australasian College of Health Sciences Instructors: Dorene Petersen, Erica Petersen, E. Joy Bowles, Marcangelo Puccio, Janet Bennion, Judika Illes, and Julie Gatti TABLE OF CONTENTS List of Tables and Figures............................................................................ iv Acknowledgments........................................................................................ v Introduction.................................................................................................. 1 Chapter 1 – Female Reproduction 1a – The Female Reproductive System............................................. 4 1b - The Female Hormones.............................................................. 9 1c – The Menstrual Cycle and Pregnancy....................................... 12 Chapter 2 – Physiology of Menopause 2a – What is Menopause? .............................................................. 16 2b - Physiological Changes of Menopause ..................................... 20 2c – Symptoms of Menopause ....................................................... 23 Chapter 3 – Allopathic Approaches To Menopausal Symptoms 3a –Diagnosis and Common Medical Treatments........................... 27 3b – Side Effects and Risks of Hormone Replacement Therapy ...... 32 3c – Retail Cost of Common Hormone Replacement
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  • Sephadex® LH-20, Isolation, and Purification of Flavonoids from Plant
    molecules Review Sephadex® LH-20, Isolation, and Purification of Flavonoids from Plant Species: A Comprehensive Review Javad Mottaghipisheh 1,* and Marcello Iriti 2,* 1 Department of Pharmacognosy, Faculty of Pharmacy, University of Szeged, Eötvös u. 6, 6720 Szeged, Hungary 2 Department of Agricultural and Environmental Sciences, Milan State University, via G. Celoria 2, 20133 Milan, Italy * Correspondence: [email protected] (J.M.); [email protected] (M.I.); Tel.: +36-60702756066 (J.M.); +39-0250316766 (M.I.) Academic Editor: Francesco Cacciola Received: 20 August 2020; Accepted: 8 September 2020; Published: 10 September 2020 Abstract: Flavonoids are considered one of the most diverse phenolic compounds possessing several valuable health benefits. The present study aimed at gathering all correlated reports, in which Sephadex® LH-20 (SLH) has been utilized as the final step to isolate or purify of flavonoid derivatives among all plant families. Overall, 189 flavonoids have been documented, while the majority were identified from the Asteraceae, Moraceae, and Poaceae families. Application of SLH has led to isolate 79 flavonols, 63 flavones, and 18 flavanones. Homoisoflavanoids, and proanthocyanidins have only been isolated from the Asparagaceae and Lauraceae families, respectively, while the Asteraceae was the richest in flavones possessing 22 derivatives. Six flavones, four flavonols, three homoisoflavonoids, one flavanone, a flavanol, and an isoflavanol have been isolated as the new secondary metabolites. This technique has been able to isolate quercetin from 19 plant species, along with its 31 derivatives. Pure methanol and in combination with water, chloroform, and dichloromethane have generally been used as eluents. This comprehensive review provides significant information regarding to remarkably use of SLH in isolation and purification of flavonoids from all the plant families; thus, it might be considered an appreciable guideline for further phytochemical investigation of these compounds.
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  • Absorption of Dietary Licorice Isoflavan Glabridin to Blood Circulation in Rats
    J Nutr Sci Vitaminol, 53, 358–365, 2007 Absorption of Dietary Licorice Isoflavan Glabridin to Blood Circulation in Rats Chinatsu ITO1, Naomi OI1, Takashi HASHIMOTO1, Hideo NAKABAYASHI1, Fumiki AOKI2, Yuji TOMINAGA3, Shinichi YOKOTA3, Kazunori HOSOE4 and Kazuki KANAZAWA1,* 1Laboratory of Food and Nutritional Chemistry, Graduate School of Agriculture, Kobe University, Rokkodai, Nada-ku, Kobe 657–8501, Japan 2Functional Food Ingredients Division, Kaneka Corporation, 3–2–4 Nakanoshima, Kita-ku, Osaka 530–8288, Japan 3Functional Food Ingredients Division, and 4Life Science Research Laboratories, Life Science RD Center Kaneka Corporation, 18 Miyamae-machi, Takasago, Hyogo 676–8688, Japan (Received February 19, 2007) Summary Bioavailability of glabridin was elucidated to show that this compound is one of the active components in the traditional medicine licorice. Using a model of intestinal absorption, Caco-2 cell monolayer, incorporation of glabridin was examined. Glabridin was easily incorporated into the cells and released to the basolateral side at a permeability coef- ficient of 1.70Ϯ0.16 cm/sϫ105. The released glabridin was the aglycone form and not a conjugated form. Then, 10 mg (30 ␮mol)/kg body weight of standard chemical glabridin and licorice flavonoid oil (LFO) containing 10 mg/kg body weight of glabridin were adminis- tered orally to rats, and the blood concentrations of glabridin was determined. Glabridin showed a maximum concentration 1 h after the dose, of 87 nmol/L for standard glabridin and 145 nmol/L for LFO glabridin, and decreased gradually over 24 h after the dose. The level of incorporation into the liver was about 0.43% of the dosed amount 2 h after the dose.
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  • Medicinal Properties of Selected Asparagus Species: a Review Polo-Ma-Abiele Hildah Mfengwana and Samson Sitheni Mashele
    Chapter Medicinal Properties of Selected Asparagus Species: A Review Polo-Ma-Abiele Hildah Mfengwana and Samson Sitheni Mashele Abstract Asparagus species are naturally distributed along Asia, Africa, and Europe and are known to have numerous biological properties. This review article was aimed to provide an organized summary of current studies on the traditional uses, phy- tochemistry, and pharmacological and toxicological studies of Asparagus laricinus Burch., Asparagus africanus Lam., Asparagus officinalis L., Asparagus racemosus Willd., and Asparagus densiflorus (Kunth) Jessop to attain and establish new insights for further researches. Information used in this review was obtained from electronic database including PubMed central, Google scholars, Science direct, Scopus, and Sabinet. Based on the present findings, the existing literature still presents some breaches about the mechanism of action of various constituents of these plants, and their relation to other plant compounds in poly-herbal formulations, as well as their long-term use and safety. More in-depth studies are still needed for active compounds and biological activities of Asparagus laricinus, Asparagus africanus, and Asparagus densiflorus. Therefore, innumerable opportunities and possibilities for investigation are still available in novel areas of these plants for future research stud¬ies. It can be concluded that all selected Asparagus species have tremendous potential to improve human health and the pharmacological activities of these plants can be attributed to bioactive phytochemicals they possess. Keywords: Asparagaceae, Asparagus africanus lam., Asparagus densiflorus (kunth) Jessop, Asparagus laricinus Burch., Asparagus officinalis L., Asparagus racemosus Willd., pharmacological actions, phytochemistry 1. Introduction Historically, plants were used for numerous purposes for mankind in general, inter alia, feeding and catering, culinary spices, medicine, various forms of cosmetics, symbols in worship and for a variety of ornamental goods.
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  • Influence of Licorice Root Feeding on Chemical-Nutritional Quality of Cow
    animals Article Influence of Licorice Root Feeding on Chemical-Nutritional Quality of Cow Milk and Stracciata Cheese, an Italian Traditional Fresh Dairy Product 1, 2, 1 3 1 Francesca Bennato y , Andrea Ianni y , Denise Innosa , Camillo Martino , Lisa Grotta , Francesco Pomilio 4, Micaela Verna 1 and Giuseppe Martino 1,* 1 Faculty of BioScience and Technology for Food, Agriculture and Environment, University of Teramo, Via Renato Balzarini 1, 64100 Teramo (TE), Italy; [email protected] (F.B.); [email protected] (D.I.); [email protected] (L.G.); [email protected] (M.V.) 2 Department of Medical, Oral and Biotechnological Sciences, “G. d’Annunzio” University Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy; [email protected] 3 Specialist Diagnostic Department, Istituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise “G. Caporale” Via Campo Boario, 64100 Teramo (TE), Italy; [email protected] 4 Food Hygiene Unit, NRL for L. monocytogenes, Istituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise “G. Caporale” Via Campo Boario, 64100 Teramo (TE), Italy; [email protected] * Correspondence: [email protected]; Tel.: +39-0861-266950 Francesca Bennato and Andrea Ianni equally contributed to this work. y Received: 20 November 2019; Accepted: 12 December 2019; Published: 16 December 2019 Simple Summary: The aim of this study was to investigate the effects of dietary licorice root supplementation on chemical and nutritional characteristics of cow milk and Stracciata cheese, an Italian traditional fresh dairy product. Our results suggest a positive role of licorice in improving the nutritional and organoleptic properties of dairy cow products, influencing various parameters such as fatty acid and volatile profiles.
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