The Fifth Cranial Nerve in Headaches J
Edvinsson et al. The Journal of Headache and Pain (2020) 21:65 The Journal of Headache https://doi.org/10.1186/s10194-020-01134-1 and Pain REVIEW ARTICLE Open Access The fifth cranial nerve in headaches J. C. A. Edvinsson1,2* , A. Viganò3, A. Alekseeva4, E. Alieva5, R. Arruda6, C. De Luca7,8,N.D’Ettore9, I. Frattale10, M. Kurnukhina11,12, N. Macerola13, E. Malenkova14, M. Maiorova15, A. Novikova16,P.Řehulka17, V. Rapaccini18,19,20, O. Roshchina4, G. Vanderschueren21, L. Zvaune22,23,24, A. P. Andreou25,26, K. A. Haanes1 and On behalf of the European Headache Federation School of Advanced Studies (EHF-SAS) Abstract The fifth cranial nerve is the common denominator for many headaches and facial pain pathologies currently known. Projecting from the trigeminal ganglion, in a bipolar manner, it connects to the brainstem and supplies various parts of the head and face with sensory innervation. In this review, we describe the neuroanatomical structures and pathways implicated in the sensation of the trigeminal system. Furthermore, we present the current understanding of several primary headaches, painful neuropathies and their pharmacological treatments. We hope that this overview can elucidate the complex field of headache pathologies, and their link to the trigeminal nerve, to a broader field of young scientists. Keywords: Fifth cranial nerve, Trigeminal ganglion, Headache, CGRP, Treatments, Migraine pathophysiology Introduction (TG). However, not all intracranial sensory fibers are tri- Considering that the classification of headache disorders geminal. For example, the posterior cranial fossa, is (ICHD-3) contains almost 300 different types of head- mainly innervated by the occipital nerves.
[Show full text]