An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Authors: Caroline Moore-Kochlacs, SRI International Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Ecol199310Cyc: Escherichia coli CFT073 Cellular Overview Connections between pathways are omitted for legibility. Peter D. Karp, SRI International succinate phosphate an apo-[c-type ferric-[N-(2,3- asp partially D-selenomethionine cytochrome] dihydroxybenzoyl) a proteinogenic glutathione 1,6- succinate D-fructofuranose deacetylated an ion N-acetyl-DL-methionine asp D-mannopyranose 6-phosphate L-alanyl-γ-D- with reduced -L-serine amino acid 2+ N-acetyl-D-mannosamine L-homoserine lactone D-cycloserine Zn cys L,L-homocystine anhydro- glycine nalidixate putrescine cadaverine L-tartrate D-tartrate succinate D-fructofuranose 6-phosphate melibionate trimer] complex poly-β-1,6- poly-β-1,6- β β an an an organosulfur compound L-methionine S-oxide putrescine D-mannitol glutamyl-meso- L-cysteine -D- -D- a proteinogenic + β thr 2+ O-acetyl-L-serine O-acetyl-L-serine β D-glucosamine α β α α an aromatic D-mannose an H 1-( -D thr cob(I)alamin gly Cd FAD D-cystine N-acetyl-D- N-acetyl- - betaine lys glutathione spermidine spermidine lys D-mannitol D-sorbitol asp fumarate fumarate L-glyceraldehyde 3-phosphate methyl -D-glucoside ala phosphate -D-cellobiose lactulose , - 2-dehydro- N-acetyl-D- N-acetyl-D- oligopeptide oligopeptide a dipeptide a short-chain carboxylate 4-hydroxybenzoate 2+ met AI-2 maltotriose ser succinate fumarate α phosphate diaminopimelate residues cellobiose cellobiose a proteinogenic amino acid shikimate L-homoserine (R)- Mn 2+ cys cys a long-chain (S)-2-hydroxybutanoate glycine cis-vaccenate acetate succinate cis-vaccenate non-specific ion/solute (S)-lactate -lactose D-galactarate D-galactarate β β N-acetyl-β-D-glucosamine(anhydrous)-N-acetylmuramate 5-dehydro-D-gluconate amino acid oligopeptide ribofuranosyl) L-homoserine D-alanine Fe 2+ FMN L-cystine muramate muramate lys D-sorbitol D-mannitol succinate (S)-malate (S)-malate D-glucopyranose 6-phosphate [+ 4 more] D-glucopyranose maltose D-glucosamine phosphate phosphate -D- N,N'-diacetylchitobiose 3-O- -D-galactopyranosyl-D-arabinose trehalose 3-deoxy-D- aldehydo-L- L-galactose glucosamine glucosamine N,N'- [+ 27 more] shikimate ammonium 2+ Fe preQ 2-oxoglutarate maltotetraose pyruvate choline thr fumarate fumarate D-glucopyranose glycolate D-gluconate D-gluconate α-lactose D-gluconate D-gluconate D-glucopyranose acetoacetate D-fructuronate D-galactonate predicted amino acid a dipeptide a dipeptide a dipeptide a dipeptide pantothenate Fe fatty acid 0 (R)-lactate betaine D-mannitol a 2,3,4-saturated fatty acid succinate fumarate a 2,3,4-saturated fatty acid maltose glycolate N-acetyl-D-glucosamine D-glucarate D-glucarate galactose melibiose GlcNAc-1,6-anhMurNAc-L-Ala-γ-D-Glu-DAP-D-Ala gluconate L-idonate iron- galactonate D-arabinose diacetylchitobiose nicotinamide [+ 3 more] glutathione S-sulfo-L-cysteine fumarate PTS system, ATP-driven L-methionine/ glycine spermidine mannitol- murein catecholate PTS system, PTS system, predicted putative Putative ATP synthase vitamin / L-cysteine N-acetylmuramic N-acetylmuramic putrescine glutathione multidrug/ sorbitol- mannose- glucose- phosphate mannitol N,N'- trehalose- transporter Putative oligopeptide dipeptide Shikimate D-methionine maltose ABC betaine ABC preferential specific maltose ABC tripeptide Sec Holo- outer cellobiose- cellobiose- transporter oligopeptide oligopeptide / thiamin ShiA AmtB AaeAB PnuC RhtA RhtB B ABC PanF CycA MntH FieF FeoB EnvC PspD YfeO YeeO YqjD HtpX ZapA ABC EamA EamB NapC RseA TcyP IgaA MreB FadL acid-specific acid-specific YhhQ TqsA ABC KgtP LldP BtsT LysP ProP BetT LysO ABC spermidine CadB MtlA specific PTS TdcC FadD TtdT SatP DcuB DauA DcuB DcuA DcuA DcuC DcuC UhpT specific PTS specific PTS BglF FadK LamB YghK LldP GntP NagE IdnT LacY SetB GntU GntT AlaE PitA PitB ABC YjbB GudP GarP (Cryptic)- GalP diacetylchitobiose- GalP LacY AtoE specific PTS AmpG KdgT IdnT GntP DgoT LgoT YagU HflD YoaE SafA FliL FucP HdeD PgaCD PgaA NfrB YhjT YeiH YddG ChiP complex of YhdW amino acid ABC DtpB DtpA DtpC DtpD ABC PhoE transporter 12 ABC transporter transporter, non- ABC PTS enzyme transporter ABC Translocon membrane specific IIB specific IIA complex of ABC ABC triphosphate transporter exporter PTS enzyme II PTS enzyme II exporter transporter efflux pump enzyme II enzyme II enzyme II transporter specific IIA specific PTS enzyme II enzyme II a standard antiporter transporter transporter transporter osmoregulatory transporter II CmtBA transporter transport component component D-mannose transporter transporter synthase CydDC component alpha 2+ β L-homoserine lactone Zn FAD α complex I poly- -1,6- partially an ion an ion an ion 4-hydroxybenzoate β thr 2+ 2+ O-acetyl-L-serine O-acetyl-L-serine -lactose β an apo-[c-type aldehydo-L- L-galactose an aromatic N,N'- amino acid 1-( -D thr (R)- D-cycloserine Mn Cd L,L-homocystine a long-chain AI-2 (S)-2-hydroxybutanoate glycine lys D-sorbitol 6-phosphate cis-vaccenoyl-CoA acetate asp asp fumarate succinate D-mannopyranose 6-phosphate D-glucopyranose cis-vaccenoyl-CoA non-specific ion/solute (S)-lactate D-glucosamine 6-phosphate ala phosphate D-galactarate D-galactarate -D- melibionate N-acetyl-β-D-glucosamine(anhydrous)-N-acetylmuramate 2-dehydro- 5-dehydro-D-gluconate N-acetyl-D- deacetylated an organosulfur compound an organosulfur compound an organosulfur compound shikimate ammonium L-homoserine Fe 2+ FMN cys cys preQ 2-oxoglutarate maltotriose pyruvate choline nalidixate ser succinate fumarate fumarate fumarate glycolate D-gluconate D-gluconate α-lactose D-gluconate D-gluconate D-glucopyranose acetoacetate D-fructuronate D-galactonate amino acid a proteinogenic a dipeptide a dipeptide a dipeptide a dipeptide OmpC ribofuranosyl) 2+ 2+ β 0 putrescine lys lys succinate D-fructofuranose 6-phosphate α maltose phosphate phosphate galactose β lactulose α α γ 3-deoxy-D- cytochrome] galactonate D-arabinose diacetylchitobiose shikimate L-homoserine pantothenate gly Fe Fe D-cystine fatty acid N-acetyl- - 1,6- (R)-lactate maltotetraose betaine spermidine D-mannitol 1-phosphate D-sorbitol 6-phosphate a 2,3,4-saturated fatty acyl CoA succinate D-tartrate (S)-malate fumarate D-fructofuranose 6-phosphate methyl -D-glucoside 6-phosphate 6-phosphate a 2,3,4-saturated fatty acyl CoA maltose glycolate N-acetyl-D-glucosamine 6-phosphate D-glucarate D-glucarate -D-cellobiose 6'-phosphate γ , - GlcNAc-1,6-anhMurNAc-L-Ala- -D-Glu-DAP-D-Ala L-idonate glucosamine poly-β-1,6- β β an a short-chain carboxylate a short-chain carboxylate a short-chain carboxylate cob(I)alamin D-selenomethionine glutathione glycine glutathione putrescine cadaverine D-mannitol thr L-tartrate succinate phosphate L-alanyl- -D- β with reduced -D- -D- amino acid a proteinogenic an an a dipeptide nicotinamide D-alanine L-cystine muramate 6- anhydro- D-mannitol 1-phosphate fumarate fumarate L-glyceraldehyde 3-phosphate N-acetyl-D-mannosamine 6-phosphate D-glucopyranose 6-phosphate D-mannitol N,N'-diacetylchitobiose 6'-phosphate 3-O- -D-galactopyranosyl-D-arabinose trehalose 6- gluconate N-acetyl-D- D-mannose oligopeptide H + [+ 27 more] [+ 27 more] [+ 27 more] N-acetyl-DL-methionine cys betaine spermidine 1-phosphate glutamyl-meso- L-cysteine ferric-[N-(2,3- cellobiose 6'- cellobiose 6'- amino acid oligopeptide oligopeptide [+ 3 more] S-sulfo-L-cysteine phosphate N-acetyl-β- (S)-malate asp D-glucopyranose 6-phosphate D-glucosamine 6-phosphate 1-phosphate melibiose phosphate glucosamine L-methionine S-oxide diaminopimelate residues dihydroxybenzoyl) phosphate phosphate a proteinogenic muramate succinate [+ 4 more] Co 2+ Co 2+ met -L-serine amino acid succinate 2+ 2+ phosphate trimer] complex Mn ZupT Mn an osmoregulated Aromatic Compound Zn 2+ Zn 2+ a phosphatidylglycerol periplasmic glucan Cofactor, Carrier, and Vitamin Biosynthesis Amine and Polyamine Biosynthesis Polymeric Degradation [+ 2 more] [+ 2 more] Compound 6 α NADH repair a mature peptidoglycan a peptidoglycan dimer an O - a [protein]- 1-myristoyl- 1-cis-vaccenoyl- methyl β-D-glucoside 3-oxo-(5Z)- a 5'-phospho- (S)-1-pyrroline- a [glutamine GDP- -D- Fermentation adenine 2503 in 23S rRNA a cis,cis-delta11,29- a cis- sn-glycerol a (3Z)-docos- an unsulfurated FAD NADH H + an N-modified palmitoyl-CoA H O ATP 34 ATP formate ATP biotin biosynthesis I superpathway of polyamine biosynthesis I pyruvate fermentation superpathway of glucose and xylose degradation Carbohydrate Degradation Degradation methylguanine sn-glycerol- 2,3- 2 synthetase]-O a cytidine mannose pro-interleukin-1β a malonyl-[acp] a protein superpathway of tetrahydrofolate biosynthesis and salvage parathion degradation (meso-diaminopimelate with pentapeptide L-cysteine a malonyl-[acp] sn-glycerol a palmitoleoyl-[acp] a myristoyl-[acp] a malonyl-[acp] cys ser a type IV prepilin 6-phosphate dodecenoyl-CoA [DNA] 5-carboxylate lys a protein 2+ 2+ superpathway of ubiquinol- superpathway of menaquinol-8 biosynthesis I phosphopantothenate biosynthesis I tetrahydromonapterin flavin biosynthesis I (bacteria and plants) molybdenum cofactor biosynthesis coenzyme A biosynthesis I (prokaryotic) prenylated FMNH biosynthesis thiamin salvage I cadaverine biosynthesis pyruvate fermentation to acetoin III trehalose degradation D-galactose degradation I (Leloir pathway) chitobiose degradation C48:2-[acp] vaccenoyl-[acp] 3-enoyl-[acp] [sulfur carrier] aminoacyl-[tRNA] Ile2 XTP Cu YbaR Cu thiamine superpathway of NAD de novo biosynthesis 2 glycine betaine to butanoate in DNA 3-phosphate 3-phosphate dihydroxybenzoate 4 -(5'-adenylyl) in tRNA Ap A biosynthesis NADH muropeptide containing) stems (meso- 3-phosphate fused DNA- Putative Putative 4 Putative thiamin ABC thiamin 8 biosynthesis (prokaryotic) demethylmenaquinol-8 biosynthesis I I (from aspartate) biosynthesis I (Gram- II (cytosolic) synthetase: 3-methyl-2- a 5,10- D-glucopyranose degradation diaminopimelate binding -L-tyrosine GDP- protease beta- protease transporter a malonyl-[acp] D-4'-phosphopantothenate arg negative bacteria) pyruvate β-D-galactose N,N'-diacetylchitobiose parathion Hypothetical methyl β-D- FAD 3-ketoacyl- acyl-CoA DNA 5' ATP XTPase: chorismate DMAPP thiamin lys pyruvate 6-phosphate containing) 6 β transcriptional lysU malonyl-CoA chorismate GTP oxobutanoate methylenetetrahydrofolate GTP cys α,α-trehalose 6'-phosphate γ peptidoglycan lytic O -alkylguanine- -ketoacyl [acyl- acyl-[acp]:1-acyl- 1-acylglycerol- acyl-acp:sn- β-ketoacyl L-cysteine Enterobactin Prepilin peptidyl- Secretion mannose ydgD ketoacyl- La IPP + L-Ala- -D-Glu- protein ygfB: ygfB glucoside 6- reductase: fre CoA thioesterase: adenylyl reductase: yjjX an ion an ion an OPG-6- GTP phosphopantothenoylcysteine asp thiamine choline NADP -dependent galactose-1- chitin endotransglycosylase: carrier protein] desulfurase: repressor glutamine hydrolase: precursor: ACP Ap A homolog: a 1,2-diacyl- methyltransferase: isochorismate ATP lysine decarboxylase: ldcC 2 DNA- sn-glycerol-3- 3-phosphate O- glycerol-3- [acyl-carrier synthetase peptidase phosphate tRNA monitor 4 synthetase: dfp glucose-6- disaccharide Putative meso-DAP-D-Ala 23S rRNA m A2503 Putative thiolase: yciA transferase: / proline nrdD synthetase: an organosulfur compound an organosulfur compound sn-glycerol (glycerophospho) D-xylose XylFGH D-xylose isochorismate 3-methyl-2-oxobutanoate GTP L-cysteine:[protein L-aspartate kinase: thiK lysine decarboxylase: cadA acetoin epimerase: mltD N-acetylmuramoyl- alkyltransferase: synthase: fabB phosphate 2-O- acyltransferase: phosphate 1-O- protein] sufS component dependent hydrolase: synthetase precursor: nudK c1990 synthase: c1091 OmpF bioC isopentenyl- synthase: menF GTP R-4'-phosphopantothenoyl- dimethylallyl arginine decarboxylase, trehalase: treF deacetylase: chbG lactose degradation III L,D- methyltransferase: glucohydrolase: flavin:NADH fadA acyl-CoA rtcA a short-chain carboxylate a short-chain carboxylate -D-glucose ∆ synthase: menF hydroxymethyltransferase: cyclohydrolase GTP cyclohydrolase molybdopterin- cysteine] oxidase: nadB cadaverine acetyl-CoA synthesis: phosphate galM N-monoacetylchitobiose phosphotriesterase- L-alanine ogt acyltransferase: yihG synthase: fabB E: c2433 protein A pth dehydrogenase deadenylase: yacA c1186 entE XDP a malonyl-[acp] methyl ester diphosphate - isochorismate cyclohydrolase L-cysteine diphosphate thiamin phosphate degradative: adiA (R)-NADHX carboxypeptidase: rlmN peptidoglycan lytic Putative beta- acyltransferase cysteine bglA Protease serine [+ 27 more] [+ 27 more] II: ribA synthase α-iminosuccinate acetoin dehydrogenase: related protein: c2495 reductase acetyl-CoA C- thioesterase: / 1-pyrroline- isomerase: idi isochorismate panB 7,8-dihydroneopterinI: folE sulfurtransferase: betaine aldehyde poxB 6'-phosphate endotransglycosylase: amidase: amiB ketoacyl-ACP plsC (glycerol-3- desulfurase: precursor: glnE Ile α degS Ap4A protease: synthase: entC I: folE 4'-phosphopantothenoylcysteine pyrophosphatase: arginine decarboxylase, acetyl-CoA synthesis: NADHX α-D-galactose α-lactose ldcA O-6-methylguanine- acyl-[acp]:1-acyl- Putative beta- enterobactin ycdH: c1144 acyltransferase: peptidyl- tesB an adenosine- tRNA - -D-mannose Putative β-ketoacyl [acyl- synthase: entC adenylyltransferase: iscS thiamine L-ornithine zwf α-D-glucose β-D-glucose mltC iscS ppdA 6-phospho- 5-carboxylate arg a peptide dATP lon triphosphate 2,5-diamino-6-(5-phospho-D- quinolinate nudF biosynthetic: speA acetyltransferase: epimerase: Entner-Doudoroff pathway I monoacetylchitobiose- L-alanyl-γ-D- DNA synthase: c1186 sn-glycerol-3- phosphate ketoacyl-ACP synthase: fadI tRNA 5'-diphospho- lysidine GMP 1-phosphate precursor: 3-oxoacyl- YeaL carrier protein] DMAPP 7,8-dihydroneopterin moeB decarboxylase: dfp monophosphate betaine aldehyde poxB 6-phospho a 2-methyladenine 2503 γ beta- dehydrogenase ATP synthase Ggt isochorismate dihydroneopterin ribosylamino)pyrimidin-4(3H)-one L-cysteine prenol atoB 6-phosphate diethylthiophosphate 4-nitrophenol glutamyl-meso- 5'-deoxyadenosine a peptidoglycan dimer L-alanyl- -D- methyltransferase: 1-myristoyl-2- phosphate 2-O- acyltransferase) synthase: entB entD [+ 4 isozymes] hydrolase: a [glutamine- synthetase: degS [ACP] a peptide isochorismate triphosphate 2-dehydropantoate a carboxy- synthase: dimethylallyl kinase: thiL dehydrogenase: Storage Compound Biosynthesis acetaldehyde acetoin (S)-NADHX nnr D-glucono- galactokinase: met glucosidase 5'-[DNA] PutA: putA / thiamin synthase: fabB D-glucopyranose hydrolase: chbF lactose in 23S rRNA with pentapeptide stem glutamyl-meso-2,6- : plsB + ADP synthetase]- mature pro- + + triphosphate 2'- diaminohydroxyphosphoribosylaminopyrimidine desulfurase: 4'-phosphopantetheine nadA synthesis: galK diaminopimelate a mature peptidoglycan a mature peptidoglycan ada palmitoleoyl- acyltransferase: c1186 entF entE FADH NAD arfB palmitate tilS synthase: H H geranyl Menaquinone adenylated GTP diphosphate ornithine betB acetoacetyl-CoA 1,5-lactone galactohydrolase: a cis,cis-delta13,31- a sulfurated bglA: c1955 2 β triphosphate Putative beta- dihydroneopterin 2-dehydropantoate epimerase: folX sufS agmatine SAM 6-phosphate N-acetyl-D-glucosamine with (L-alanyl-γ-D- strand (non- (meso-diaminopimelate diaminopimeloyl- sn-glycerol plsC ala an N-terminal (3Z)-dec-3- glt L-tyrosine interleukin-1 c1189 diphosphate biosynthesis Menaquinone deaminase: ribD [small subunit of isopentenol pyrophosphatase: thiamin diphosphate decarboxylase: speC polyhydroxybutanoate biosynthesis poxB acetyl-CoA a 3- synthase ketoacyl-ACP triphosphate an [L-cysteine pantetheine- quinolinate 6-phosphogluconolactonase: + α-D-galactose lacZ containing) D-alanyl-D-alanine 3-oxo-C50:2-[acp] [sulfur carrier] enoyl-CoA biosynthesis 2-reductase: panE glycine betaine NADP -dependent 6-phosphate glutamyl-meso-2,6- reducing terminus) 3-phosphate 1-myristoyl- L-phenylalanyl- 34 synthase: ispA protein 7,8-dihydromonapterin 5-amino-6-(5-phospho- molybdopterin kinase: thiM nudJ lys 3-hydroxyacyl-CoA acetoin UDP-α-D-glucose a [protein]-S- a peptide β a lysidine oxodocosanoyl- synthase: c1186 diphosphatase: desulfurase]-S- GTP 3',8'- phosphate ornithine pgl glucose-6- D-glucopyranose 1-phosphate a guanine in DNA a (5Z)-3-oxotetracos- enterobactin [type IV prepilin] -D-glucose an N-modified Lpp protein triphosphate agmatinase: speB diaminopimeloyl-D- 1,2-bis-cis- sn-glycerol methanol a tRNA Ile2 [acp] + + RsxB menD: menD nudB β-alanine D-ribosylamino)uracil synthase] sulfanyl-L-cysteine quinolinate decarboxylase: speF dehydrogenase: β β L-alanyl-D- methyl-L-cysteine 6-phosphate in tRNA H AtpI H geranyl menD: menD (R)-pantoate cyclase: adenylyltransferase: acetyl-CoA NADH D-gluconate phosphate -D-galactose -D-glucose diethylphosphate alanine) tetrapeptide vaccenoyl- 3-phosphate 5-enoyl-[acp] amino acid a 3-oxoglutaryl- 2-succinyl-5- 5-amino-6-(5- phosphoribosyltransferase lysine fadB glucokinase: glutamate diphosphate 2-succinyl-5- 7,8-dihydroneopterin moaA coaD prenyl phosphate glutathionylspermidine 6-phosphate dehydrogenase: phosphatidate [acp] methyl ester enolpyruvyl-6-hydroxy- phosphoribosylamino) molybdopterin (8S)-3',8-cyclo-7,8- (decarboxylating): nadC decarboxylase: ldcC acetyl-CoA [+ 2 isozymes] glk farnesyl enolpyruvyl-6-hydroxy- 3'-phosphate putrescine dAdoMet biosynthesis 6-phosphogluconate zwf kojibiose degradation L-Ala-D/ 3-oxo-glutaryl- 3-cyclohexene- pantothenate uracil reductase: ribD synthase dihydroguanosine 3'-dephospho-CoA lysine acetyltransferase: (S)-3- D-glucopyranose diphosphate 3-cyclohexene- flavin 6-phospho L-Glu H + PntAB H + synthetase: NaMN decarboxylase: cadA hydroxybutanoyl- dehydrogenase, 6 4 PqiB [acp] methyl ester 1-carboxylate 7,8-dihydromonapterin 5-amino-6-(5-phospho- sulfurtransferase: 5'-triphosphate glutathione spermidine atoB 6-phosphate epimerase: N -(3-methylbut- an inactive a [protein]- an O - a mechlorethamine a (3R)-3- salicin 6- poly-β-1,6- β-D-cellobiose a long-chain an oxidized queuosine at GDP-α-D- a trans-2- a [protein]-L- dTDP-2,3,6- synthase: ispA 1-carboxylate panC prenyltransferase: CoA decarboxylating: gnd D-glucono- a sulfurated a cis,cis-delta17,35- itaconate a (4Z)-hexadec- sn-glycerol a cis- sn-glycerol FMN NADH H + PPP H O stearoyl-CoA H O oleoyl-CoA H O hippurate ADP ATP HMP-PP (1R,6R)-2- ynjE dephospho-CoA kojibiose SAM methylthymine derived interstrand a malonyl-[acp] a malonyl-[acp] a palmitoyl-[acp] hydroxydocosanoyl- i 2 2 nitroaromatic position 34 2 mannose enoyl-[acyl- trideoxy-3-C- YidG reductase: fabG D-ribitylamino)uracil cyclic pyranopterin nicotinate- ubiX cadaverine 1,5-lactone melibiose degradation ycjG 2-en-1-yl)- ribonucleoside L-cysteine phosphate N-acetyl-D- 6'-phosphate fatty acyl-CoA glt GMP methionine ITP (1R,6R)-2- acetoacetyl-CoA D-ribulose kojibiose [sulfur carrier] 37 C54:2-[acp] 4-enoyl-[acp] 3-phosphate vaccenoyl-[acp] 3-phosphate Asp (2E,6E)-farnesyl succinyl-6- dihydromonapterin monophosphate kinase: coaE spermidine enoyl-CoA adenosine triphosphate in DNA DNA crosslink [acp] (3R)- glucosamine compound of a tRNA carrier protein] Peptide HMP-PP methyl-3-amino- a (3R)-3-hydroxyglutaryl- succinyl-6- chorismate 5-amino-6-(5- mononucleotide 6-phosphogluconolactonase: L-alanyl-L- NADPH- enoyl-[acyl- diphosphate hydroxy-2,4- 7,8-dihydroneopterin reductase: folM a thiocarboxylated synthase: moaC prenylated FMNH synthase: speE glutathionylspermidine hydratase: 5-phosphate phosphorylase: in tRNA reductase methionine hydrolase: 4-dehydro- glutamate / [acp] methyl ester (R)-pantothenate adenylyltransferase: 2 hydroxymyristoyl- GDP- carrier- hydroxy-2,4- phospho-D- coenzyme A aminopropylcadaverine pgl melibiose glutamate 4 Succinyl-CoA β FMN acyl-CoA acyl-CoA dependent acyl-CoA Putative Ap A cyclohexadiene- [small subunit of cyclic synthetase: gss fadJ ycjT O -methylthymine- 6-phospho- 6-phospho- - inorganic sulfoxide 3 cof α ITPase: all-trans- 4-amino-4- nadD β-D-glucose NM - β-ketoacyl [acyl- β [acyl carrier poly-β-1,6- mannose protein] -D-glucose asp aspartate asp YgiS cyclohexadiene- ribitylamino)uracil synthase: speE 5 -ketoacyl acyl-acp:sn- acyl-acp:sn- reductase: fre thioesterase: thioesterase: nitroreductase glutamyl-Q thioesterase: hippuricase: synthetase: 3-hydroxyglutaryl- chorismate 1-carboxylate dihydroneopterin tetrahydromonapterin D-ribulose 5-phosphate molybdopterin pyranopterin [+ 2 isozymes] ribulose- Ribose 5- D-gluconate isopentenyl- DNA synthetase alpha beta- D-glucosyl-(1- triphosphatase: GMP reductase yjjX ABC octaprenyl- deoxychorismate pantothenate phosphatase: yigB 1-phosphate alanylglutamate ribonucleoside interstrand carrier protein] [acyl-carrier glycerol-3- glycerol-3- protein] N-acetyl-D- NfsA: nfsA tRNA(Asp) mannosyl reductase: HMP-PP glt glt [acp] methyl ester synthase: menH 1-carboxylate aldolase: folB synthase] phosphate nicotinate adenine (R)-3- phosphate 3- phosphate 6-phosphate α-galactosidase: adenosine tRNA methyltransferase: ogt chain: c5037 glucosidase 4)-D-glucose Putative ygiF yciA yciA yciA c4924 msrA: msrA lysU diphosphate synthase: kinase: coaA spermidine aminopropylcadaverine glutathionylspermidine triphosphate DNA crosslink synthase: fabB dehydratase: fabZ glucosamine N nucleosidase: hydrolase: fabI hydrolase: transporter CadC dehydratase: fabZ chorismate (1R,6R)-6-hydroxy-2- synthase: menH 3,4-dihydroxy- 5-amino-6-(5- dinucleotide hydroxybutanoyl- poly-[(R)-3- crotonyl-CoA β-phosphoglucomutase: dipeptidase: pepD protein] phosphate 1-O- phosphate 1-O- bglA: c1955 glucohydrolase: NAD(P)H synthetase: dTDP-2,3,6- synthase: ispB 6-hydroxymethyl- pabA pabB epimerase: isomerase melA methylthiolase: Succinyl-CoA flavin:NADH inorganic acyl-CoA acyl-CoA acyl-CoA ppnN an acyl-[acyl- nudJ IDP 2-butanone- + + D-xylose phosphogluconate reductase O-4-methylthymine- repair -deacetylase: gmm protein- lyase: ubiC succinylcyclohexa-2,4- (1R,6R)-6-hydroxy-2- D-4'- phospho-D- molybdopterin NAD NAD CoA hydroxybutanoate] rpe ycjU Putative beta- synthetase beta synthase: fabB acyltransferase acyltransferase 3-hydroxydecanoyl- bglB thioesterase: nitroreductase: gluQ thioesterase: trideoxy-3-C- a (2E)-enoylglutaryl- all-trans- 7,8-dihydropterin Putative acyl-coa A: rpiA UDP-glucose miaB DNA salicin 6- pgaB reductase triphosphatase: thioesterase: carrier protein] methionine- succinylcyclohexa-2,4- 4-amino-4- phosphopantothenate 4-phosphate synthase: dehydratase: edd UDP-glucose:α- activase: nrdG glycosylase: ketoacyl-ACP Putative beta- (glycerol-3- (glycerol-3- [acyl-carrier- nfsB benzoate 5'Ap3A HMP-P methyl-3-amino- glt GltP glt OpgD [acp] methyl ester octaprenyl diene-1-carboxylate ribitylamino)uracil synthetase, synthetase, xylose 4-epimerase: β-D-glucose α β chain: c5036 phosphate [+ 2 isozymes] ycdH: c1144 ppa tesB tesB a hydroxylamino tesB gly 4-hydroxybenzoate 2-amino-4-hydroxy-6- deoxychorismate synthase: ribB dehydrogenase: ribose-5- -D-galactose -D-glucose glt ala 6 methyltransferase: ycaQ phosphate D-ribose 5- S-oxide 4-dehydro- diene-1-carboxylate phosphatase: ybjI moaE moaD glutamine NH - D-xylulose glycogen degradation I D-galactose- 6-phosphate 2-methylthio-N - synthase: c1186 ketoacyl-ACP phosphate protein] group-containing glutamyl- diphosphate o-succinylbenzoate superpathway of adenosylcobalamin salvage from cobinamide I 3 isomerase: phosphate galE glucohydrolase: D-mannose enoylglutaryl- hydroxymethyldihydropteridine c2464 KDGP 1-phosphate 5'-deoxyadenosine dimethylallyladenosine 37 met an unsulfurated an active ada synthase: acyltransferase) acyltransferase) partially queuosine at guanine phosphate GDP reductase: α-D-gulose o-succinylbenzoate aminodeoxychorismate 1-deoxy-L-glycero- dependent: dependent: xylA 5-phosphate dehydratase: fabA bglB compound [acp] methyl ester synthase: menC diphosphokinase: folK ARP acyl-CoA isomerase: UDP-glucose [sulfur carrier] 5'-deoxyadenosine : plsB : plsB a (2E)-docos- acetate β-D-glucose a long-chain msrB 4-hydroxybenzoate synthase: menC lyase: pabC tetrulose 4-phosphate nadE nadE poly-[(R)-3- a glycogen uridylyltransferase: in tRNA met ribonucleoside a DNA containing a mechlorethamine itaconyl-CoA GDP c1186 deacetylated poly- β-D-glucose FMNH NAD + stearate position 34 oleate a protein-L- glt glt EcnA molybdopterin rpiB 4-epimerase: phosphate 2 phosphate diphosphate reductase: fabI (2-amino-4-hydroxy- cob(II)inamide dehydrogenase: a [protein]-S- a cis,cis-delta19,37- 2-enoyl-[acp] β 6-phosphate fatty acid Asp octaprenyltransferase: 2-succinylbenzoate hydroxybutanoate] D-xylulose α-D-glucose galT triphosphate a thymine in DNA AP sites on derived bis- -1,6-N-acetyl- of a tRNA methionine- + α GadC FimC 2-succinylbenzoate 7,8-dihydropteridin-6- NAD fadE 2-keto-3- glycogen UDP- -D-galactosec2560 methyl-L-cysteine guanyl compound 3-oxo-C56:2-[acp] β-D-glucose D-glucosamine ubiA 4-aminobenzoate molybdopterin 1-phosphate trehalose degradation reductase opposing strands 1-cis-vaccenoyl- salicyl alcohol (R)-S-oxide a glutaryl-[acp] methyl ester yl)methyl diphosphate 6,7-dimethyl-8- xylulokinase: D-ribose 5- deoxygluconate phosphorylase: Degradation/Utilization/Assimilation - Other a (6Z)-3-oxooctadec- 1-palmitoylglycerol 6-phosphate 4-aminobutanoate 4-aminobutanoate o-succinylbenzoate--CoA superpathway of thiamine diphosphate biosynthesis I superpathway of pyridoxal 5'-phosphate biosynthesis and salvage adenylyltransferase: transketolase: VI (periplasmic) sn-glycerol- ribityllumazine butanoyl-CoA xylB phosphate 6-phosphate glgP 3-phosphate glt GltS glt ligase: menE o-succinylbenzoate--CoA mog tktA phosphoglucomutase: 6-enoyl-[acp] 3-phosphate 3-oxopimeloyl- 3-octaprenyl-4- dihydropteroate synthase: ribH Tetrapyrrole Biosynthesis aldolase: eda acrylonitrile ligase: menE D-erythrose molybdopterin [corrinoid adenosyltranferase]- D-xylulose D-sedoheptulose D-glyceraldehyde[+ 2 isozymes] α pgm α,α-trehalose Protein [acp] methyl ester hydroxybenzoate 4-(2'-carboxyphenyl) synthase: folP cys an -limit dextrin degradation I acetoacetate MreC 4-phosphate adenine cob(II)inamide 5-phosphate yobA synthase: fabF 3-octaprenyl-4- -4-oxobutyryl-CoA 4-(2'-carboxyphenyl) 7-phosphate 3-phosphate D-glyceraldehyde D-glucopyranose glucose and glucose-1-phosphate degradation degradation γ β 6,7-dimethyl-8-(1-D-ribityl)lumazine superpathway of heme b a [ribosomal an odd numbered a CcmE-[c-type a CcmG protein L-Ala-γ-D-Glu- a peptidoglycan L-alanyl- -D- a (3R)-3- a (3R,6Z)-3- 1-( -D L-glycero-L-galacto- a peptide with a [protein] a (3R,7Z,10Z L-glycero- dTDP-4-dehydro- dTDP-3-N,N- precursor -4-oxobutyryl-CoA D-erythrose- dinucleotide pyruvate trehalase: treF (to acetyl CoA) a sulfurated UDP-N-α-D- a cis,cis-delta15,27- a (7Z)-hexacos- an ADP-sugar a uracil in DNA a nucleoside ADP GDP Cr 6+ Conserved [+ 2 isozymes] hydroxybenzoate 1,4-dihydroxy- L-cysteine:[protein superpathway of heme biosynthesis from uroporphyrinogen-III 3-phosphate limit dextrin α-1,6- 6-phosphate acrylonitrile protein S12] straight chain 2,3,4- cytochrome-- with reduced a malonyl-[acp] an mRNA a malonyl-[acp] dimer (generic) glutamyl-L-lysyl- hydroxyicosanoyl- hydroxyoctadec- ribofuranosyl) 3-oxo-myristoyl-CoA octuluronate RNA an N-terminal C-terminal glt [DNA] ,13Z,16Z,19Z)-3- L-galacto- GDP 3-C-methyl- dimethylamino- 2'-AMP 7,8-dihydropteroate 4-phosphate molybdopterin biosynthesis from glutamate butanoyl Transaldolase α-D-glucose meso-DAP-D-Ala acetylmuramate C46:2-[acp] 7-enoyl-[acp] triphosphate GTP hypothetical decarboxylase: ubiD 1,4-dihydroxy- cysteine] glucohydrolase: acetoacetate [sulfur carrier] L-aspartate 89 saturated fatty acid CcmH disulfide] D-alanyl-D-alanine [acp] nicotinamide 1-phosphate L-methionine DNA hydroxydocosa- octuluronate nucleoside 2,6-dideoxy- a 3-oxopimeloyl- 2-naphthoyl- riboflavin dehydrogenase: molybdotransferase: phosphate Glyceraldehyde cysteine residues (3R)- 6-enoyl-[acp](3R)- L-glutamate L-glycero- formate 4-oxo-2,3,6- protein 2-naphthoyl- sulfurtransferase: A: talA 1-phosphate acetoacetyl-CoA α [acp] methyl ester CoA dihydrofolate synthase: ribC moeA [corrinoid adenosyltranferase]- uroporphyrinogen-III 3-phosphate glgX D-arabinose degradation I α-D-glucose β-D-glucose complex hydroxymyristoyl- hydroxymyristoyl- polymerase: 7,10,13,16,19- L-galacto- di- and -L-allose trideoxy-α- 2-octaprenylphenol CoA epd glt transaldolase: UDP-N-acetylmuramate:L- ribosome- Membrane-bound ADP-sugar uracil-DNA acetyl-CoA C- AMP 3-oxoacyl- chromate RseB MinE synthase: synthetase: folC iscS MoO - cob(I)inamide dehydrogenase acrylamide transferase: β β [acyl carrier [acyl carrier nicotinamide L-glycero- DNA- methionine polB pentaenoyl-[acp] octuluronate triphosphate D-glucose 3-oxo-pimeloyl- synthase: erythronate- 2 talB Glucose-1- protein short chain γ -ketoacyl [acyl- dependent -ketoacyl lytic murein D-alanyl-D-alanine diphosphatase: glycosylase: acyltransferase: ribosomal kinase reductase: menB L-cysteine riboflavin molybdopterin glutamate--tRNA a debranched atoA atoD alanyl- -D-glutamyl-meso directed RNA 3' to 5' [ACP] GTP hydrolase: 2-octaprenylphenol uroporphyrinogen A: c1843 maltotetraose D-arabinopyranose phosphoglucomutase: methylthiotransferase: acyl-CoA thiol:disulfide carrier protein] [acyl-carrier transglycosylase carboxypeptidase: nudE protein] protein] riboside ung L-galacto- aminopeptidase: protein S6 (GTP): adk yieF L-glycero-kinase: ydjH [acp] methyl ester menB 7,8-dihydrofolate 4-phosphate ligase: gltX α-limit dextrin phosphatase Putative acetoacetyl-CoA -diaminoheptanedioate- mRNA fadI polymerase: reductase: reductase: nudJ dTDP-4-dehydro- 6-hydroxylase: ubiI 1,4-dihydroxy-2- desulfurase: cofactor decarboxylase: hemE glyceraldehyde- rimO synthetase: fadK oxidoreductase: synthase: fabB protein] dacD dehydratase: fabZ dehydratase: fabZ phosphorylase: octuluronate- map modification: proofreading a (7Z,10Z,13Z,16Z reductase: fabG Glu n-butanoate D-erythrose pgm precursor: agp interferase: E: mltE ADP-sugar L-galacto- dTDP-3-N,N- adenosine (2E,6E)-farnesyl 1,4-dihydroxy-2- sufS erythronate- an L-glutamyl-[tRNA ] F6P D-arabinose amidase: D-alanine ligase: mpl 3-ketoacyl-CoA rpoC exonuclease: fabG nrdD 3-C-methyl- KefG 3-(all-trans naphthoyl-CoA riboflavin kinase: ribF 4-phosphate 3-phosphate maltodextrin acetyl-CoA fatty acyl-CoA ccmG Putative beta- synthase: fabB D-alanyl-D-alanine pyrophosphatase: 3-hydroxydecanoyl- 3-hydroxydecanoyl- xapA 1-phosphate rimK ,19Z)-3-oxodocosa- octuluronate dimethylamino- a (3R)-3-hydroxypimeloyl- diphosphate naphthoyl-CoA (2E,6E)-farnesyl a 5,10- an [L-cysteine 4-phosphate coproporphyrinogen III isomerase: fucI [+ 5 isozymes] ybeM yoeB Membrane-bound an AP (apurinic uracil thiolase: fadA rpoB rpoA GMP 2,6-dideoxy- YbiJ -octaprenyl) 1,4-dihydroxy- adenosylcobinamide dehydrogenase: glucokinase: acetyltransferase: a [ribosomal carboxypeptidase: nudF aldolase: ydjI AMP dnaQ 7,10,13,16,19- Cr 3+ superoxide 1-phosphate 4-oxo-2,3,6- Putative [acp] methyl ester diphosphate methenyltetrahydrofolate desulfurase]-S- dehydrogenase: phosphorylase: synthetase: fadD UDP-N-acetylmuramoyl- ketoacyl-ACP Putative beta- lytic murein [acyl-carrier- [acyl-carrier- or apyrimidinic) β-L-galactose benzene-1,2-diol all-trans- 1,4-dihydroxy- Glutamyl-tRNA Transketolase L-lyxose gapA glk Putative 5'-deoxyadenosine an unsulfurated GTP a nucleoside 5'- pentaenoyl-[acp] α citrate citrate citrate 2-naphthoyl- a [ThiS sulfur- FMN pdxB folate transformations I malP D-ribulose D-glucopyranose atoB met protein S12]-3- a c-type γ synthase: c1186 an RNase ketoacyl-ACP transglycosylase dacA protein] protein] α-D-ribose- site created met a peptide a [protein] C- trideoxy- - 3-hydroxypimeloyl- 2-octaprenyl-6- octaprenyl- 2-naphthoyl- all-trans- methenyltetrahydrofolate sulfanyl-L-cysteine cobinamide reductase: hemA 2: tktB degradation D-glucopyranose amidase: [sulfur carrier] a CcmH- a c-type L-alanyl-D- - an RNase product nicotinamide monophosphate permease CoA a 7,8-dihydrofolate cysteine :[Thil sulfur- carrier protein] coproporphyrinogen coproporphyrinogen III 6-phosphate methylsulfanyl- an odd numbered cytochrome product with synthase: A precursor: mltA dehydratase: fabA dehydratase: fabA 1-phosphate by glycosylic acetyl-CoA lauroyl-CoA aldehydo-L- terminal α-L- dGTP L-glucose [acp] methyl ester diphosphate CoA octaprenyl- cyclohydrolase: folD 2-oxo-3-hydroxy-4- kinase: cobU mixed acid fermentation transketolase: 13-DPG c2457 acetyl-CoA CcmG disulfide cytochrome glutamyl-meso-2,6- with a 5' OH an α-D-aldose a (2E,6Z)- DHAP RNA hydroxyphenol hydrolase: FMN III oxidase: hemF α D-ribulokinase: L-aspartate 89 AMP straight chain 2,3,4- diphosphate biogenesis γ AMP a (2E)-icos- glutamate-α- a protein TatABC a protein diphosphate protein cysteine] ThiS phosphobutanoate a tetrahydrofolate glutamate-1-semialdehyde dehydrogenase: hemN β-L-lyxopyranose -D-glucose maltotriose glucose diaminopimeloyl- a 3' phosphate c1186 L-alanyl- -D- 1-phosphate octadecadienoyl- bond cleavage arabinuronate dehydratase: fabZ methylase: ubiG menI synthase: ispB hydrolase: an N 10 - adenylyltransferase: tktA fucK protein CcmE a cis,cis-delta17,29- 2-enoyl-[acp] ZinT succinate succinate synthase: ispB sulfurtransferase: adenylyltransferase: adenosyl-cobinamide Putative oxygen L-lyxose 1-phosphate dehydrogenase: acrylate saturated fatty acyl CoA GlcNAc-1,6- glutamyl-L- D-alanine [acp] L-glutamate 2-methoxy- menI Dihydrofolate phosphohydroxythreonine 5,6-dimethylbenzimidazole phosphoglycerate D-alanine a (2E)-enoylpimeloyl- all-trans-octaprenyl formyltetrahydrofolate iscS thiF ribF D-glyceraldehyde pyruvate phosphate glutamate-1- independent phosphoenolpyruvate D-glyceraldehyde maltotriose gcd 3-oxo-C48:2-[acp] a lipid II lysyl-D-alanine CitT 6-(all-trans- 1,4-dihydroxy- all-trans-octaprenyl reductase: folA protoporphyrinogen IX isomerase: kinase: pgk D-ribulose 1-phosphate anhydro-MurNAc- [acp] methyl ester diphosphate 1,4-dihydroxy- a carboxy- aminotransferase: serC 3-phosphate semialdehyde 2,1- 3-phosphate glucosidase: a (9Z)-3-oxooctacos- citrate citrate octaprenyl)phenol 2-naphthoate a [ThiI sulfur- FAD nicotinate- coproporphyrinogen rhaA L-arabinose D-glucono- pentapeptide 2-naphthoate diphosphate dihydrofolate phosphoribosylglycinamide 4-phospho- cobinamide-P 3-phospho- malZ 9-enoyl-[acp] enoylpimeloyl- 2-octaprenyl-6- carrier protein]-S- adenylated-[ThiS nucleotide--dimethylbenzimidazole aminomutase: hemL III oxidase: chuW Glyceraldehyde L-xylulose degradation I 1,5-lactone CheB reductase: folM formyltransferase 1: purN 1-deoxy-D- guanylyltransferase: pyruvate kinase: pykA phosphoenolpyruvate D-glycerate phosphoglucomutase: YccA [acp] methyl ester 1,4-dihydroxy- sulfanyl-L-cysteine sulfur-carrier protein] hydroxy-L- phosphoribosyltransferase: cobT formyltetrahydrofolate HemY 3-phosphate D-ribulose- Eco methoxyphenol 4- cobU 5-amino-levulinate Pyruvate kinase I: pykF carboxylase: ppc L-xylulose maltose 2-naphthoate 1,4-dihydroxy- threonine xylulose-5- deformylase: purU protein: phosphoglycerate pgm phosphate L-arabinopyranose reductase: fabI hydroxylase: ubiH dehydrogenase a (2R)-2-hydroxy even α (R)-3- N,N'- a [protein disulfide 2-naphthoate adenylate:persulfide 4-hydroxythreonine- phosphate α-ribazole 5'-phosphate hemY protoporphyrinogen IX kinase: aldolase: fucA L-arabinose UDP-N-acetyl- -D-muramoyl-L- a [PTS enzyme phosphoenol a reduced DNA containing 1-chloro-2,4- sn-glycerol (2E,11Z)- a cis,cis- 2-methoxy-6-all octaprenyltransferase: a tetrahydrofolate adenosylcobinamide-GDP A: c1843 mutase: gpmA amylomaltase: 2,3- a holo-[EntB aryl- a cis,cis-delta15,33- a (5Z)-tetracos- hydroxybutanoyl- a purine glutathione L-selenocystathionine oxalate acetyl-CoA a ribonucleoside Rh an acyl-CoA H O an oligopeptide ATP salicylate propionamide 5'Ap3A O-phospho- octaprenyltransferase: transferase: thiF 4-phosphate synthase: gcv porphobilinogen pyruvate oxaloacetate lyxK isomerase: numbered straight chain alanyl-γ-D-glutamyl-meso-2,6- I]-L-histidine pyruvate a malonyl-[acp] NADP + H + ferredoxin [iron- a malonyl-[acp] H O a base with lesion dinitrobenzene DL-allothreonine diacetylchitobiose 2 trp octadecenoyl-CoA isomerase] delta19,31-3- a protein a pimeloyl-[acp] methyl ester trans-octaprenyl- menA adenosylcobalamin carrier protein] 2 3-phosphate diphosphate L-tyrosine D-glyceraldehyde protoporphyrinogen glyceraldehyde- 2-phospho- malQ D-gluconate 2,3,4-saturated fatty acid dihydroxybenzoate C52:2-[acp] sulfur] cluster 5-enoyl-[acp] CoA ribonucleoside CTP enoyl-CoA carrying a Putative menA salvage from cobalamin menaquinol-8 biosynthesis dehydrogenase: dxs system: synthase: hemB L-xylulose - araA diaminopimeloyl-D-alanyl-D-alanine ribonucleoside- hydroxyC50:2- ATP- 2-methoxy-1,4- 3-phosphate carboxy-adenylated- glycolaldehyde pdxA cobalamin 5'- gcvH lpdA dehydrogenase: hemG malate 3-phosphate D-glycerate DHAP diphosphate chitin hydratase: disulfide bondthiol- [acp] 3-oxoacyl- amidase: dependent YabI CpxP pimeloyl-[acp] benzoquinol tyr [ThiS sulfur- 5-phosphate D-glucopyranose L-ribulose Phosphoenolpyruvate- DNA glutathione S Cystathionine acetyl- Possible acyl-CoA peptidyl- Putative HlyB demethylmenaquinol-8 3-amino-1- 1-deoxy-D- gcvP gcvT 10 porphobilinogen D-lactate dehydrogenase: mdh dehydrogenase: Putative glycerol- fadB disulfide ybeM methyl ester 2-octaprenyl- cob(I)alamin 1-deoxy-D- phosphate an N - Pyruvate formate- enolase: glycolaldehyde short chain acyl-CoA muramoylpentapeptide 2,3- β-ketoacyl [acyl- ferredoxin- β-ketoacyl acyl-CoA allothreonine reductase: disaccharide dipeptidase: [ACP] HslVU demethylmenaquinol-8 carrier-protein] demethylmenaquinol-8 hydroxyacetone methionine dehydrogenase: ldhA gapA L-ribulose-5- protein containing -transferase: beta-lyase: metC CoA:oxalate hypoxanthine thioesterase: tryptophanase: salicyl- 6-methoxy-1,4- xylulose-5- xylulose 5- synthase: cobS a (6S)-5- protoporphyrin IX lyase 2 activating [+ 4 isozymes] eno L-rhamnose dehydrogenase: ribulokinase: carboxypeptidase: dacA carrier protein] NADP + thioesterase: purine nucleoside 3-phosphate acetaldehyde- nrdB nrdA deacetylase: enoyl-CoA exchange: reductase: Putative protease: esterase: bioH sulfurtransferase: thiI formyltetrahydrofolate hydroxymethylbilane phosphate 3- glucokinase: synthetase: fadK phosphotransferase dihydroxybenzoate- [acyl-carrier a base gstA CoA- oxidase tesB dcp tnaA AMP demethylmenaquinone phosphate 2-iminoacetate demethylmenaquinone 1-phosphate phosphate synthase: formyltetrahydrofolate enzyme: pflC degradation I araB yciA phosphorylase: Beta- cytidyltransferase: hydratase: a [protein disulfidedsbD a cis,cis-fabG amidase: benzoquinol 13-DPG epimerase: phosphoenol aldA fatty acyl-CoA muramoyl pentapeptide [aryl-carrier synthase: fabB reductase: protein] lyase (glycine- transferase: ribonucleoside- chbG xdhD: c3459 ligase: hslV hslU tyr methyltransferase: ubiE synthase: thiH methyltransferase: ubiE metH synthase: hemC ferrochelatase: siroheme biosynthesis (S)-malate glk ptsA: ptsA with lesion deoD glutathione S- cystathionase: c3696 acyl-CoA fadJ isomerase] a pimeloyl-[acp] methylase: synthase: dxs adenosylcobalamin methenyltetrahydrofolate (R)-lactate [+ 4 isozymes] L-ribulose 5- carboxypeptidase: dacC protein] ligase: entE Putative beta- fpr synthase: fabB (R)-3- forming): glyA diphosphate delta19,31-3- c2457 YceI cob(II)alamin AIR a thiocarboxy- pyridoxine pyridoxine 5'- hemH ulaE pyruvate α-L-rhamnose synthetase: fadD [+ 3 isozymes] hydrolase: transferase: c3407 yfdE thioesterase: (S)-3-hydroxy-(11Z) with reduced L- c2434 a peptide thiosulfate/ biotin BioP biotin ubiE 1-deoxy-D-xylulose menaquinol-8 5'-phosphate cyclohydrolase: folD fumarase A: fumA phosphoglycerate glycolate phosphate ketoacyl-ACP hydroxybutanoyl- reductase: N-acetyl-β-D- a dipeptide oxo-C50:2-[acp] propanoate 6-methoxy-3- menaquinol-8 2-iminoacetate [ThiS-Protein] phosphate hydroxymethylbilane [+ 2 isozymes] Putative pyruvate Putative beta- mug yfcF yciA a peptide indole pyruvate -octadecenoyl-CoA cysteine residues ADP AMP sulfate sulfate ABC sulfate 8-amino-7- 5-phosphate uroporphyrinogen-III L-rhamnose D-glucopyranose α-D-ribose- acetate phosphomethylpyrimidine adenosylcobalamin [+ 4 isozymes] kinase: pgk hexulose-6- kinase: L-ribulose-5- a (R)-2-hydroxy even UDP-N-acetylmuramoyl-L- a 2,3- synthase: c1186 an oxidized ketoacyl-ACP CoA CDP-glycerol a 2'- nrdF nrdE glucosaminyl- an alcohol superoxide transporter oxononanoate methyl-2-all- synthase: pyridoxamine a 5,10- Putative uroporphyrin-III C- formate acetyl-CoA AMP a [PTS enzyme 1-phosphate acetaldehyde salicylate- pyridoxine 5'-phosphate uroporphyrinogen- protoheme IX mutarotase: 6-phosphate phosphate 4- diphosphate numbered straight chain alanyl-D-γ-glutamyl-meso-2,6- π dihydroxybenzoyl- ferredoxin [iron- thioesterase: tesB a purine base seleno-L- gly acetate oxalyl-CoA (1->4)-D- trans-octaprenyl- synthase: thiC pdxJ methyltransferase: hemX 3-phospho- phosphate pykA D-alanine I]-N -phospho- pyruvate NADPH synthase: a DNA containing pyruvate deoxyribonucleoside adenylate synthase: bioF thiamin salvage II 1-deoxy-D-xylulose methenyltetrahydrofolate fumarate rhaM epimerase: 2,3,4-saturated fatty acyl CoA sulfur] cluster a modified 2,4-dinitrophenyl- glucosamine 1,4-benzoquinol cob(II)alamin- kinase: pdxK phosphatase: cobC III synthase: hemD D-glycerate isomerase: diaminopimeloyl-D-alanine L-histidine [EntB aryl- c1186 an apurinic/ homocysteine 5'-diphosphate a carboxylate YcdO RsxE 5-phosphate:thiol pyridoxal pyridoxamine S-adenosyl-L- Hydrogen Pyruvate β a cis,cis-delta17,35- nucleobase S-glutathione sulfate/ 8-amino-7-oxononanoate [corrinoid HMP-P methylenetetrahydrofolate formate hydrogenlyase phosphate acetaldehyde citrate synthase: gltA sgbU -L- araD carrier protein] (R)-3- apyrimidinic site 2-octaprenyl- sulfurtransferase: NAD salvage pathway I (PNC VI cycle) kinase: pdxK coenzyme B uroporphyrinogen-III methionine:uroporphyrinogen- Production fumarate reductase: Probable kinase 3-oxo-C54:2-[acp] thiosulfate hydroxymethylpyrimidine adenosyltranferase] pyridoxine 12 5,10-methylenetetrahydrofolate:glycine complex: hycE acetyltransferase: pta dehydrogenase: adhE rhamnopyranose [+ 2 isozymes] 3-methyl-6- dehydrogenase: folD III C-methyltransferase: cysG phosphoglycerate L-ribulose 5- I: pykF fucose degradation hydroxybutanoate sulfate sulfate 7,8- phosphomethylpyrimidine thiG pyridoxal 5'-phosphate pyridoxamine hydroxymethyltransferase: glyA hydrogen hycG hycF hycC phosphate acetaldehyde frdC frdA frdB frdD L-rhamnose 2-deoxy-D-ribose degradation I D-xylulose a (7Z)-3-oxohexacos- ABC methoxy-1,4- hydroxymethylpyrimidine uroporphyrinogen precorrin-1 citrate mutase 2: gpmB phosphate diaminopelargonic kinase: thiD + 5'-phosphate hycD hycB fdhF acetyltransferase: eutD pyruvate isomerase: 5-phosphate 7-enoyl-[acp] transporter benzoquinol 2-[(2R,5Z)-(2-carboxy- NAD kinase: production V dehydrogenase: eutE succinate Skp acid synthase: bioA kinase: thiD decarboxylase: hemE 2,3-bisphosphoglycerate- L-ribulose-5- rhaA β-L-fucopyranose hydroxylase: cob(I)alamin- 4-methylthiazol-5(2H)- pdxY pyridoxine 5'- Putative uroporphyrin-III C- citrate hydro-lyase (cis- 2-deoxy-D-ribose HMP-PP independent phosphate 4- sulfate CysZ sulfate CsrD hydroxymethylpyrimidine pyridoxal phosphate pyridoxamine a 5,10- methyltransferase: hemX formate 7,8-diaminopelargonate ubiF [corrinoid ylidene]ethyl phosphate citrate lyase activation coproporphyrinogen III CO H acetyl phosphate acetaldehyde aconitate-forming): acnA phosphoglycerate epimerase: keto-L-rhamnulose L-fucose an [RNA]-3'- core M-antigen bis(guanylyl (S)-3- a (3R)-3- a [protein]- a cis,cis- kinase: pdxK a 5-methyltetrahydrofolate 2 2 Putative bis-MGD cofactor a uridylylated 4-hydroxy- (2E,9Z)- 4-methyl-5-(β- adenosyltranferase] kinase: oxidase: 5'-phosphate methylenetetrahydrofolate S-adenosyl-L- citrate hydro-lyase: acnB mutarotase: fucU a uracil in DNA (I) a cis,cis-delta13,25- an acyl-[acyl- an aminopeptidase [DNA] ammonium ATP CO benzylbenzoate Tyr lauroyl-CoA H O citrate glyoxylate acetamide mutase: gpmM araD ribonucleoside- a cis,cis-delta7,25-C44:2-[acp] a malonyl-[acp] oligosaccharide- (variant) monomer a malonyl-[acp] molybdopterin) a malonyl-[acp] hydroxybutanoyl- H O hydroxyhexacosanoyl- 2 L-cystathionine 3-sulfinoalanine D-tyrosyl-tRNA 2 L-tyrosine hexadecenoyl-CoA a palmitoyl-[acp] delta13,31- an octanoyl-[acp] L-ornithine Putative 3-demethylubiquinol-8 cobalamin ethanol ribokinase: chaperone 2 PII protein L-threonine dIDP HMP-P hydroxyethyl)thiazole thiamine NAD + synthetase, pdxK pdxH oxidase: pdxH coproporphyrinogen methionine:precorrin-1 C- D-gulosides a 5'-hydroxy- 2',3'- GTP lipid A (E. coli undecaprenyl C44:2-[acp] carrier protein] CoA [acp] substrate phosphate enoyl-CoA 3-hydroxy glyoxylate Putative 3'-dephospho- 5,10- a reduced cis-aconitate 2-phospho- [+ 2 isozymes] D-allose c0331 α cofactor (3R)- protein-tyrosine enoyl-[acyl- Putative LdtB dethiobiotin adenosyltransferase: phosphate III oxidase: hemF methyltransferase: cysG acetate kinase: ackA dehydrogenase: adhE -L-fucopyranose conversion to ribonucleotide- amidase: 3-demethylubiquinone- hydroxyethylthiazole glutamine CoA D-glycerate D-xylulose cyclophosphate K-12 core type) diphosphate hydroxymyristoyl- hydratase: carrier- C50:2-[acp]3-oxoacyl- reductase: nucleoside synthetase: ynfK btuR synthase: thiE methylenetetrahydrofolate hydrogenase 3 [+ 2 isozymes] degradation 2-deoxy-D-ribose D-glucosides bifunctional Putative Carbamate carboxylesterase: acyl-CoA Citrate lyase: phosphatase: beta- ElyC 8 3-O- phosphomethylpyrimidine dependent: nadE triphosphoribosyl- D-threo-isocitrate 3'-[RNA] (no GlcNAc) fadB [ACP] ghrA ybeM kinase: thiM adenosylcob(III) nicotinate adenine dinucleotide NMN PLP reductase: metF protoporphyrinogen IX precorrin-2 5-phosphate L-rhamnulofuranose L-fucose β-ketoacyl [acyl-carrier β-ketoacyl [acyl- bis-MGD Putative beta- acyl-CoA [acyl carrier aminopeptidase: cystathionine PII-UMP cysteine sulfinate 4-hydroxy- Tyr pphA protein] ketoacyl- diphosphate NlpI dethiobiotin kinase: thiD N 10 -formyl-tetrahydrofolate biosynthesis enolase: 5-phosphate uracil DNA deoxyribonuclease kinase: arcC bioH D-Tyr-tRNA thioesterase: citE citF methyltransferase: ubiG 4-methyl-5-(2- alamin-[corrinoid dephospho-CoA hydrogenase: acetate ethanol hydro-lyase (cis- D-allopyranose isomerase: fucI a D-guloside protein] synthase: fabB carrier protein] cofactor ketoacyl-ACP thioesterase: protein] ypdF β-lyase: malY deuridylylation: desulfinase: csdA L-threonine enoyl-CoA reductase: reductase: ACP glyoxylate kinase: ndk Putative synthetase: bioD eno D-guloside 3- RNA glycosylase yjjV: yjjV Carbamate carboxylesterase: deacylase: dtd yciA [+ 2 isozymes] protein-tyrosine phosphonooxyethyl) adenosyltranferase] thiamin phosphate nicotinate- synthase: citG precorrin-2 hycB hycD aconitate-forming): acnA D-allose rhamnulokinase: M-antigen synthase: fabB chaperone: yciA dehydratase: fabZ [+ 2 isozymes] glnD aldolase: hydratase: fabI a cis,cis-fabG reductase: amidase: D-ornithine HMP-PP HemY protein: hemY deoxyribose- ligase: rtcB Putative beta-ketoacyl- (G:U synthase: aminopeptidase: Putative yjfP cysteine sulfinate acyl-CoA phosphatase: synthase: Ivy ubiquinol-8 mononucleotide 2'-(5''-triphospho- a tetrahydrofolate hycC hycF phosphoenol kinase: rhaB L-fuculose dehydrogenase: kinase: c5349 ltaE fadJ a (2E)-hexadec- delta13,31-3- ghrB dITP c2457 dethiobiotin thiazole dehydrogenase: cysG D-threo-isocitrate phosphate ACP synthase: c1186 specific): nth ligase: Putative beta- fdhD c1186 (S)-3- 3-hydroxydecanoyl- mtfA desulfinase: sufS pphB c1186 thiamine α-D-ribosyl)-3'- hycG hycE pyruvate ycjQ deoxyribonuclease thioesterase: (S)-3-hydroxy-(9Z) 2-enoyl-[acp] oxo-C50:2-[acp] adenylyltransferase: hydro-lyase: acnB alsK L-rhamnulose a 3-dehydro- waaL ketoacyl-ACP β hydroxybutanoyl- a [protein]- a 3-oxodecanoyl- glycolate acetate lactose aldehydo-D-allose aldolase: L-fuculokinase: -ketoacyl [acyl-carrier- ycfH: ycfH UMP Tyr tesB acetate oxaloacetate -hexadecenoyl-CoA biotin thiamine monophosphate nadD S-adenosyl-L-methionine cycle I dephospho-CoA protoporphyrin IX sirohydrochlorin pyruvate 1-phosphate D-guloside pyruvate D-tyrosine a tRNA L-tyrosine [acp] AcrZ glutathione biosynthesis Dihydrofolate reductase: folA H degradation II 6-phosphate deoC fucK α β synthase: c1186 [bis-MGD cofactor [acyl-carrier CoA protein] L-homocysteine benzoate benzyl alcohol a PII protein Aer kinase: thiL apo-citrate lyase methionine synthase: metH 2 pyruvate fermentation D-threo-isocitrate GMP a 5'-phospho- a [DNA]-3'- , - uracil carbamoyl-phosphate glycolaldehyde synthase: bioB phosphate coenzyme B NAD salvage pathway II (PNC IV cycle) kinase: 3-dehydro- di-trans,octa-cis chaperone]- thioesterase: tesB a proteinogenic sulfite gly 12 RNA a cis,cis-delta9,27-3-oxo-C46:2-[acp] unsaturated protein] dehydratase: fabA a peptide ala synthase: thiE NaMN nicotinamide phosphoribosyl- dihydrofolate ferrochelatase: hemH sirohydrochlorin to ethanol I pykA allose-6- [DNA] E. coli M amino acid YjfY lipoate glutathione-glutaredoxin Putative α-lactose Rhamnulose- D-glyceraldehyde L-fuculose 1-phosphate D-guloside 4- LPS -undecaprenyl bis-MGD synthase: fabB a (2E)-hexacos- a [DNA]-3'- a 5'-phospho- biotin thiamin diphosphate SAM dephospho-CoA reductase: folM [+ 2 isozymes] ferrochelatase: cysG isocitrate phosphate acetaldehyde aldehyde laurate cys glt + amidase: c2457 Pyruvate 1-phosphate 3-phosphate epimerase: diphosphate a cis,cis-delta15,27- 2-enoyl-[acp] hydroxyl [DNA] biosynthesis and redox reactions NAD transferase: citX pyruvate dehydrogenase: icd isomerase: (S)-3- kinase aldolase: rhaD ycjR 3-oxo-C46:2-[acp] incorporation II thiamin phosphate [+ 2 isozymes] a holo [citrate 5,10-methylenetetrahydrofolate:glycine a 5-methyltetrahydrofolategcv system: gcvH protoheme IX siroheme rpiB acetaldehyde L-fuculose- trehalose degradation I (low osmolarity) hydroxybutanoate S-adenosylmethionine a 7,8-dihydrofolate I: pykF YejM Hypothetical glutathione nicotinate lyase acyl- hydroxymethyltransferase: glyA lpdA gcvP gcvT 2-oxoglutarate 3'-ketolactose dehydrogenase: phosphate a 3-dehydro- a 3-oxoacyl-[acp] YegB octanoate glutamate--cysteine thioredoxin synthetase: c4547 Respiration D-allulose 6- protein yjhT thiamine oxidized phosphoribosyltransferase: carrier protein] Pyruvate DHAP L-lactaldehyde adhE D-glucoside octanoate- ligase: gshA pathway + pyruvate phosphate aldolase: fucA NAD methionine a (6S)-5-formyltetrahydrofolate formate-lyase D-glucoside 3- α,α-trehalose 6-phosphate precursor non- monophosphate glutaredoxin lipoate biosynthesis and incorporation I pncB citrate lyase acetaldehyde lipoate salvage I synthetase, adenosyltransferase: metK 2-oxoglutarate decarboxylation to succinyl-CoA 2 activating D-allulose-6- kinase: thiL nicotinate synthetase: dehydrogenase: ω lipoylated L-γ- a glutaredoxin dithiol an oxidized 5,10- β dehydrogenase: HypE a (3R)-3- an N-acylated microcin B17 precursor an N -(1- a cis,cis- UDP-2,3- glutamine met SAH enzyme: pflC Putative lactate D-lactate 3-keto- -D- phosphate 3- D-mannose DHAP L-lactaldehyde ycjS an apo-[c-type 3-oxo-(11Z)- a 5'-NAD- phosphoenol apo domain glutamylcysteine thioredoxin citC methylenetetrahydrofolate eutE trehalose-6-phosphate a 5'-hydroxy- 1-palmitoylglycerol a cis,cis-delta11,23- a cis,cis-delta19- carbamoyl- acetyl-CoA propanoate a glutamine N-methyl-L- a [protein] Ser/Thr an acetic ester H O ATP biotin thiamin diphosphate dependent: an octanoyl-[acp] thymidylate synthase: thyA methylenetetrahydrofolate a [2-oxoglutarate galactose epimerase: an [RNA]-3'- a cis,cis-delta5,17-C36:2-[acp] a malonyl-[acp] a cis-delta11-C30:1-[acp] a malonyl-[acp] a palmitoleoyl-[acp] a malonyl-[acp] cytochrome] a CcmH protein a malonyl-[acp] hydrogenase hydroxytetracosanoyl- aliphatic-L- capped-[RNA] peptide containing hydroxy-2- 2 an octanoyl-[acp] a hexanoyl-[acp] delta11,29- a butanoyl-[acp] diacetamido- a protein (R)-lipoate an acetyl-holo [+ 4 isozymes] dehydrogenase: dehydrogenase: degradation GTP 3-phosphate C42:2-[acp] 37-C56:2-[acp] octadecenoyl-CoA ATP synthetase ITP tryptophan pyruvate IDP EcnB LolA a [lipoyl-carrierligase: lplA glutathione glutaredoxin:protein folate polyglutamylation reductase: metF dehydrogenase: folD dehydrogenase alsE a D-glucoside hydrolase: treC ribonucleoside- ribonucleotide- with reduced L- with an internal phosphate maturation protein [acp] amino acid azole residues serine/ oxopropyl) 3-hydroxy 2,3-dideoxy-α- HtpG lipoate-ATP nicotinate adeninenadE NMN [citrate lyase acyl- c5039 ldhA acetyl-CoA (3R)- enoyl-[acyl- enoyl-[acyl- Putative 6 disulfide a 5,10-methylenetetrahydrofolate a 5,10-methenyltetrahydrofolate 6 fructose degradation D-mannopyranose 3'-[RNA] inosine triphosphate threonine -[protein]- protein] N - synthetase: dinucleotide octanoyl cobalamin-independent S-adenosylhomocysteine E2 protein] N Dihydrolipoamide 3'-phosphate cysteine residues disulfide bridge hydroxymyristoyl- carrier- carrier- C48:2-[acp]3-oxoacyl- beta- nucleoside D-glucuronate adenylate reductase: grxB Thioredoxin NMN carrier protein] acetyl-CoA formate F6P 6-phosphate acetyl-CoA C- Putative pyrophosphatase: rdgB RNA octanoyl-L-lysine gshB transferase: bis(guanylyl molybdenum homocysteine nucleosidase: mtn -lipoyl-L-lysine glucokinase: glk β β acyl-[acp]:1-acyl- β-ketoacyl [acyl- β carbamoyl- [acyl carrier Putative glutamine synthetase N-methyl-L- microcin B17 protein L-arginine acetylesterase: protein] protein] [ACP] ketoacyl- biotin-ATP diphosphate transferase: a tetrahydrofolate methenyltetrahydrofolate dehydrogenase: (R)-lactate β-D-fructofuranose mannose-6- D-glucopyranose 3'-PO4/5'- -ketoacyl [acyl-carrier -ketoacyl [acyl-carrier -ketoacyl [acyl- acyltransferase: propionate decapping lipoyl glutaredoxin: grxC reductase: amidohydrolase: cofactor) biosynthesis transmethylase: metE dihydrolipoate (S)-lactate β-D-galactose D-glucopyranose 6-phosphate hippuricase: nucleoside triphosphate tryptophan kinase: srkA aes reductase: ligase: birA lplA lipB cyclohydrolase: folD Metabolic Regulator Biosynthesis lpdA acetaldehyde 1-phosphate phosphate protein] synthase: fabB protein] synthase: fabB sn-glycerol-3- carrier protein] thiol:disulfide carrier protein] -[HypE] protein] CoA- adenylyltransferase: hydrolase: precursor reductase: reductase: ACP kinase: ndk synthase: glutathione trxB pncC Secondary Metabolite Biosynthesis dehydrogenase: OH RNA fadI pyrophosphohydrolase: a cis,cis- UDP-2,3- Spy lipoyl-adenylate NAD salvage a protein with reduced a [lipoyl-carrier protein] MoO - methionine synthase: metH 1-phosphofructokinase: isomerase: Putative beta-ketoacyl- Putative beta-ketoacyl- phosphate 2-O- synthase: fabB oxidoreductase: synthase: fabB ligase: hypF dehydratase: fabZ c4924 glnE oxidase: solA protease: protein protein fabI fabI fabG synthase: a peptide lipA nicotinate- 2 L-homocysteine S-ribosyl-L-homocysteine γ [+ 3 isozymes] dehydrogenase: ligase: rtcB 3-ketoacyl-CoA transferase: mazG nudC diacetamido- pathway IV (from 6 folylpoly- - 5,10-methylenetetrahydrofolate:glycine 10 c5035 kinase: yeaG a (2E)-oct- a (2E)-hex- delta11,29-3- ITP YqfA YggT L-cysteine residues N -octanoyl-L-lysine molybdopterin acyl carrier protein metabolism I an N -formyltetrahydrofolate adhE fruK manA ACP synthase: c1186 ACP synthase: c1186 acyltransferase: Putative beta- ccmH Putative beta- 3-hydroxydecanoyl- c5024 tldD tldE deglycase: c1186 a [lipoyl-carrier nicotinamide riboside) mononucleotide glutamate hydroxymethyltransferase: glyA ppGpp biosynthesis fructose 1,6- thiolase: fadA IMP a [protein] (L-serine/L- oxo-C48:2-[acp] biotinyl-5'- 2,3-dideoxy-α- lipoyl- 6 methylerythritol phosphate pathway I trehalose biosynthesis I Dihydrolipoamide plsC hchA acetate an alcohol pyruvate 2-enoyl-[acp] 2-enoyl-[acp] a 3-oxohexanoyl- protein]-N -[(R) 1-(β-D adenylyltransferase: cofactor bis(molybdenum acetaldehyde bisphosphate F6P ketoacyl-ACP ketoacyl-ACP a HypE [acyl-carrier- adenylyl- adenylate adenylate- a reduced synthetase: 10 autoinducer AI-2 biosynthesis I dehydrogenase: an aliphatic a carboxylate a 5'-phospho- formaldehyde threonine) phosphate [acp] D-mannuronate lipoyl cofactor) an N - GMP synthase: c1186 an apo-[c-type synthase: c1186 hydrogenase protein] [glutamine NMN trp -dihydrolipoyl]- ribofuranosyl) thioredoxin nadD folC a 5,10- D-glyceraldehyde pppGpp D-glucopyranose a [2-oxoglutarate a [2-oxoglutarate dehydrogenase: Inorganic Nutrient Metabolism L-amino acid adenosine-[RNA] -protein synthase: lipA formyltetrahydrofolate acyl-carrier protein lpdA RNA synthase] microcin B17 a peptide CybC L-lysine nicotinamide NaMN bis(molybdenumsynthase: mobA S-ribosylhomocysteine methylenetetrahydrofolate pyruvate guanosine-5'- UDP-α-D-glucose eutE a cis,cis-delta7,19-3-oxo-C38:2-[acp] a cis-delta13-3-oxo-C32:1-[acp] 1-palmitoyl-2-palmitoleoyl- cytochrome]-- maturation dehydratase: fabA acetyl-CoA palmitoleoyl-CoA acetate propionyl-CoA a [protein]- ligase: lplA NAD phosphorylation ribosylnicotinamide 10-formyl- acyl carrier protein 3-phosphate 6-phosphate dehydrogenase dehydrogenase a (2E)-tetracos- (R)-lactate cytidylyl molybdenum lyase: luxS SAM guanosine 3'-diphosphate triphosphate,3'-diphosphate 6 6 CcmH disulfide protein-S- L-arginine a [lipoyl-carrier and dephosphorylation kinase: nadR a [lipoyl-carrier cofactor) methylene- phosphodiesterase:4-phosphopantetheinyl E2 protein] N E2 protein] N -S- (aminomethyl)phosphonate degradation sn-glycerol 3-phosphate 2+ a tetrahydrofolate tetrahydrofolylpolyglutamate acetaldehyde oleate β-oxidation Fatty Acid and Lipid Degradation methylphosphonate a cis,cis-delta13,25- a cis,cis-delta21,39- carboxamide 2-enoyl-[acp] PspA SohB 6 cofactor biosynthesis 5'-deoxyadenosine sulfide(2-) 6 Fe an [Fe-S] cluster 5'-triphosphate 3'- phosphatase: gpp superpathway of sulfate assimilation and cysteine biosynthesis two-component alkanesulfonate monooxygenase protein]-N -[(R NMN protein]-N -[(R)- met bis(molybdenum tetrahydrofolylpolyglutamate synthetase: folC acpH transferase entD: entD 1-deoxy-D- trehalose-6- -dihydrolipoyl- succinyldihydrolipoyl- fatty acid β-oxidation I 3-oxo-C44:2-[acp] 3-oxo-C58:2-[acp] + scaffold protein an acyl- GTP degradation I )-lipoyl]-L-lysine NAD MoO - dihydrolipoyl]-L-lysine cofactor) synthetase: folC xylulose-5- diphosphatase: spoT phosphate L-lysine L-lysine ethanol 2 guanylyl molybdenum 10 [+carrier 2 isozymes] protein pyrophosphokinase: relA (aminomethyl)phosphonate NMN molybdopterin synthase: mobA an N - oleate PicU cofactor biosynthesis a 5,10- phosphate SAH synthase: otsA dehydrogenase: a (3Z)-alk-3- sulfate 3-phospho-D-glycerate an alkylsulfonate FMNH adenylyltransferase: bis(guanylyl formyltetrahydrofolate aminomethylphosphonate (methyl)phosphonate 2 cofactor molybdenum cofactor methylenetetrahydrofolate synthase: dxs adhE enoyl-CoA a pyrimidine base a single stranded a [ThiI sulfur- 1-myristoyl- DNA with adenine:7,8- a [protein]- a 5'-phospho- an S-(1-hydroxy- a [protein chain a cis,cis- a [protein]- nadR MoO - short chain N-acetyltransferase: phnO α-D-ribose 1- a cis,cis-delta17,29- FAD FMN NAD(P)H H + glyoxylate pyruvate a decanoyl-[acyl- a decanoyl-[acyl- cytidylyltransferase: 2 molybdopterin) GTP α,α-trehalose D-3-phosphoglycerate a cis,cis-delta3,15-C34:2-[acp] a cis-delta19-C38:1-[acp] a malonyl-[acp] DNA with ring- an N-terminal cys carrier protein]- sn-glycerol a myristoyl-[acp] dihydro-8- [DNA] a carboxylic ester L-allo-threonine ribonucleoside- CDP-glycerol 2-oxopropyl) elongation factor a dodecanoyl-[acp] a myristoyl-[acp] delta15,33- a protein pyridine nucleotide NAD molybdopterin S-adenosylhomocysteine ppGpp Dihydrolipoamide [+ 2 isozymes] acyl-CoA dodecenoyl- sulfate methylphosphonate lesion in DNA a malonyl-[acp] dGTP a malonyl-[acp] IMP L-threonine ATP 2'-deoxyguanosine L-histidine IMP taurine ABC cytidylyl cofactor (acetamidomethyl)phosphonate C48:2-[acp] 34 carrier protein] carrier protein] taurine taurine YhhN + mocA 1-deoxy-D-xylulose 6-phosphate dehydrogenase: serA opened apurinic/ L-cysteinyl- L-cysteine 3-phosphate oxoguanine mismatch [RNA] -[protein]- P]-L-lysine 3-hydroxy protein- transhydrogenase: kinase: NAD cofactor molybdenum cofactor nucleosidase: mtn dehydrogenase: synthetase: fadK CoA D- adenylyltransferase: 5-triphosphate enoyl-[acyl- enoyl-[acyl- enoyl-[acyl- Putative 3'-monophosphate transporter molybdenum an apo acyl- 5-phosphate ethanol apyrimidinic site L-cysteine EF-P-Lys34 histidine OpgG pntA pntB nadK trehalose-6- lpdA α-D-ribose-1-(2-N- cysD cysN synthase: phnH [YedK-protein] carrier- carrier- carrier- C52:2-[acp]3-oxoacyl- beta- GMP cofactor guanylyltransferase: carrier protein fatty acyl-CoA isomerase: 3-phospho-hydroxypyruvate bifunctional Exodeoxyribonuclease FAD:protein carboxylesterase: FMN 2-keto-4- hydroxylase: guanylyl S-ribosyl-L- GDP guanosine-3',5'- β β β cysteine adenine L-allo- RNA 5' [ACP] pros- reductase: mobA phosphate [+ 3 isozymes] synthetase: fadD fadJ acetamidomethylphosphonate) APS α-D-ribose-1-(methyl)phnL phnG phnI DNA -ketoacyl [acyl-carrier -ketoacyl [acyl-carrier -ketoacyl [acyl- acyl-[acp]:1-acyl- IX: exo FMN yjfP reductase: hydroxyglutarate epmC protein] protein] protein] ketoacyl- molybdenum homocysteine pyrophosphokinase: relA bis(diphosphate) 3'- phosphatase: FMN genome desulfurase: inosinate glycosylase: threonine adenylyl protein reductase: kinase: guaC GDP kinase: ndk ∆ 3 ∆ 2 -5-triphosphate synthase: phosphonate- glycosylase: protein] synthase: fabB protein] synthase: fabB dGTP carrier protein] sn-glycerol-3- transferase: fre aldolase: eda a [protein chain reductase: reductase: reductase: ACP GDP diphosphokinase: spoT diphosphatase: spoT superpathway of glycolysis and the Entner-Doudoroff pathway -cis- 3-phosphoserine nucleosidase: 3' -> 5' carboxylesterase: a cis,cis- cusS YfdV + cofactor otsB oleoyl-CoA phnH phnL phnG phnI alkanesulfonate reductase: triphosphohydrolase: dgt synthase: fabB maintenance iscS phosphate 2-O- mutY aldolase: ltaE transferase: deglycase: elongation factor fabI fabI fabI fabG a [protein]- NADP S-ribosylhomocysteine GDP kinase: adk -trans- adenylyl-sulfate aminotransferase: serC 5-triphosphate nei Putative beta-ketoacyl- Putative beta-ketoacyl- exonuclease: xthA ftp bioH synthase: a peptide YfcA MEP α-D-ribose 1- α monooxygenase: ssuE protein: yedK ppnN rtcA hchA EF-P]-N-(β-lysyl)-5- a (2E)-dodec- a (2E)-dec- a (2E)-tetradec- delta15,33-3- π GMP lyase: luxS α,α-trehalose enoyl-CoA kinase: cysC -D-ribose-1- ACP synthase: c1186 ACP synthase: c1186 Putative beta- acyltransferase: cytidine a 3- c1186 2'-deoxyguanosine N -phospho- MlaC Putative acyl-coa + (4S)-4-hydroxy- sn-glycerol 34 2-enoyl-[acp] 2-enoyl-[acp] 2-enoyl-[acp] oxo-C52:2-[acp] GDP D-glucopyranose 6-phosphate (acetamidomethylphosphonate) methylphosphonate- ssuD FMN ketoacyl-ACP a [ThiI sulfur- plsC FMNH NAD(P) hydroxy-L-lysine L-histidine (S)-4,5- isomerase: 3-phospho-L-serine a [DNA]- an apurinic site 2 3-phosphate oxododecanoyl- 2-C-methyl-D- dehydrogenase: 5-triphosphate a 5'-phospho- a modified D-ribofuranose a [protein]-FMN- 2-oxoglutarate acetaldehyde gly dihydroxypentan- fadB 3-hydroxybutyryl- PAPS 5-triphosphate reductase: fre nucleotide- 4-oxo-2-pentenal PPP synthase: c1186 a single stranded ala carrier protein]- adenine within DNA [DNA] a nucleoside 5'- AMP an alcohol a carboxylate a 5'-(5'- a [protein]- [acp] erythritol 4-phosphate c2464 α-D-ribose-1-(2-N- [DNA] nucleobase i L-threonine 2,3-dione diphosphatase: phnM a cis,cis-delta5,17-3-oxo-C36:2-[acp] a cis-delta21-3-oxo-C40:1-[acp] 2'-deoxyguanosine DNA-YedK S-sulfanyl- 1,2-dimyristoyl- 5-phosphate hypoxanthine monophosphate diphosphoadenosine)- (R)-lactate CoA phosphoadenosine α 3'-phosphate L-cysteine superpathway of L- Amino Acid Biosynthesis cytidylyltransferase: + acyl-CoA fatty a (2E)-2- acetamidomethylphosphonate) Phosphoserine -D-ribose-1- thiazolidine linkage L-cysteine (ribonucleoside)-[RNA] PspB superpathway of aromatic amino acid biosynthesis superpathway of L- superpathway of branched chain amino acid biosynthesis superpathway of L-lysine, L-threonine and L-methionine biosynthesis I superpathway of L-homoserine arginine biosynthesis I (via L-ornithine) NADP -dependent epimerase: fadJ sn-glycerol YbaV tryptophan biosynthesis superpathway of L- superpathway of L- ispD dehydrogenase: acyl-CoA enoyl-CoA -5-triphosphate phosphosulfate phosphatase: serB methylphosphonate a cis,cis-delta19,31- LapA isoleucine biosynthesis I and L-methionine biosynthesis glucose-6-phosphate 3-phosphate phenylalanine biosynthesis tyrosine biosynthesis 4-(cytidine 5'- fadE synthetase: 3-hydroxyacyl- diphosphatase: phnM reductase: cysH 5-phosphate 3-oxo-C50:2-[acp] D-erythrose D-erythrose (2R,4S)-2-methyl-2,4- dehydrogenase: zwf Putative α-D-ribose-1-(2-N- phosphoenolpyruvate D-erythrose pyruvate oxaloacetate diphospho)-2-C- fadD acyl-CoA CoA ser carbon- 4-phosphate 4-phosphate oxaloacetate phosphoenol D-erythrose thr glt glucose-6-phosphate crotonase: sulfite phosphoenolpyruvate asp methyl-D-erythritol dihydroxydihydrofuran- (2E,9Z)-octadecenoyl-CoA a 2,3,4-saturated epimerase: a 2,3,4- acetamidomethylphosphonate) phosphorous aspartate 4-phosphate pyruvate 4-phosphate isomerase: pgi short chain dehydrogenase: an aldehyde FMN 3-deoxy-7- Acetolactate aspartate 4-diphosphocytidyl- 3-one c5023 fadB saturated (3R)-3- 5-phosphate lyase: phnJ di-trans,octa-cis 3-O-β-D- 2-dehydro-3-deoxy- an unstable a cis,cis- QseG threonine Putative fatty acid acyl-CoA fadE assimilatory serine lipid A-core 3-oxo-(9Z)- 3-oxo-(7Z)- a thymine peptidoglycan D- D-ribofuranose an unfolded a [protein]- 3-deoxy-7- phosphoheptulonate transaminase: synthase transaminase: aspC aspartate 2-C-methyl- Putative 3- [+ 2 isozymes] hydroxyacyl-CoA Reactive Blue 5 -undecaprenyl a cis,cis-delta13,31- lysine within palmitoyl-CoA 1-butanesulfonate L-threo-3- NADH L-lactaldehyde RecA filament- a cis,cis-delta5,17-3- L-threonine 3- YcjF 3-deoxy-7- superpathway of L-methionine dehydratase: 6-phospho D-glucono-1,5-lactone carbon-phosphorous sulfite reductase 5-phospho-α-D-ribose a cis,cis-delta3,21-C40:2-[acp] a malonyl-[acp] a cis-delta17-C36:1-[acp] a malonyl-[acp] a malonyl-[acp] hexadecenoyl-CoA tetradecenoyl-CoA glycol in DNA alanyl-DAP crosslink 5-phosphate uracil galactopyranosyl- a lipoyl-[acp] D-arabinonate a mercapturate L-selenocysteine delta19,37- a hexanoyl-[acp] L-histidine pro YfbV phosphoheptulonate synthase: aroG aspC 3-deoxy-7- isozyme kinase: lysC tagatose-6- hydroxyacyl-CoA synthetase: Putative acyl-coa acetyltransferase: cysE C50:2-[acp] phenylserine hydroxyC36:2[acp] dGMP protein O-phosphate biosynthesis (transsulfuration) D-erythritol Polyprenyl Biosynthesis a 2,3,4- lyase: phnJ diphosphate D-arabinose gcv protein H Putative acyl-coa (S)- DNA complex 3-hydroxy- chaperonin protein- phosphoheptulonate phosphoheptulonate tdcB phosphate dehydrogenase: fadK a 2,3,4-saturateddehydrogenase: (NADPH): cysI cysJ 1,2-cyclic phosphate RecA filament- 3-oxoacyl- Putative synthase: aroG [+ 2 isozymes] asp II: ilvM ilvG [+ 2 isozymes] kinase: ispE 6-phosphogluconolactonase: saturated (3S)-3- dehydrogenase: lactaldehyde C56:2-[acp] histidine synthase: aroG synthase: aroG asp ketose/ c2464 α 2-dehydro- alkanesulfonate NADH DNA complex [ACP] 3-oxoacyl- beta- ATPase: [+ 2 isozymes] 3-deoxy-D-arabino- threonine 2-phospho-4-(cytidine pgl c2467 fatty acyl CoA 5-phospho- -D-ribose O-acetyl-L-serine 5-phospho-α-D-ribosyl dye- acetyl-CoA C- acetyl-CoA C- bifunctional peptidoglycan Ribosomal c2464 deoxyguanylate oxaloacetate [+ 2 isozymes] AI-2 polyisoprenoid biosynthesis (E. coli) hydroxyacyl-CoA hydrogen sulfide β-ketoacyl [acyl-carrier β-ketoacyl [acyl-carrier undecaprenyl- β-ketoacyl [acyl- galactoside- 3-deoxy-D- Putative reductase: stabilisation: reductase: [ACP] groL groS tele- heptulosonate- aspartate [+ 2 isozymes] [+ 2 isozymes] deaminase: L-aspartyl- aldose 5'-diphospho)-2-C- [+ 3 isozymes] Putative 3- 1,2-cyclic phosphate 1,2-cyclic phosphate phosphate decolorizing acyltransferase: acyltransferase: thymine DD- small subunit lipoyl-protein monooxygenase: phenylserine pyrophosphatase: selenocysteine kinase: gmk ketoacyl- YbhG aspartate F6P protein] synthase: fabB protein] synthase: fabB pyrophosphate carrier protein] arabinose pentonate acyl-CoA hippuricase: yahK recF fabG reductase: kinase: 3-deoxy-D-arabino- 7-phosphate kinase: lysC aspartate ilvA (S)-2-acetolactate 4-phosphate isomerase: methyl-D-erythritol D-gluconate 6-phosphate hydroxyacyl-CoA α phosphodiesterase: acquisition peroxidase: fadI fadI glycol DNA endopeptidase pseudouridine ligase: lipB ssuD aldolase: ltaE nudC lyase: sufS a cis,cis- ACP ATPase: 3-deoxy-D-arabino- kinase: lysC (S)-3-hydroxy-(9Z) 5-phospho- -D-ribosyl dehydrogenase: c4924 [+ 3 isozymes] a cis,cis-fabG cpxA heptulosonate- 3-deoxy- agaS O-acetylserine yfeX Putative beta-ketoacyl- Putative beta-ketoacyl- pyrophosphatase: synthase: fabB glycosylase: galactohydrolase: aldolase: yagE a stabilizedrecR recO delta5,17-3- synthase: ravA a [protein]- thr D-proline OsmB CheZ 3-dehydroquinate [+ 2 isozymes] transaminase: (2Z)-2-aminobut- aspartate- 2-C-methyl-D- IPP 6-phosphofructokinase: -octadecenoyl-CoA 3-ketoacyl- dehydrogenase: 1,2-cyclic phosphate phnP 3-ketoacyl-CoA 3-ketoacyl-CoA MepH: mepH synthase A: rsuA (S)-propane- D-arabino- heptulosonate- Ketol-acid [+ 2 isozymes] coenzyme A a phosphate lpxT lacZ fadE dGDP delta19,37-3- c1186 τ 7-phosphate aspC 2-enoate N-acetylglutamate erythritol 2,4- phosphogluconate fructose-1,6- c2467 phosphodiesterase: phnP sulfhydrylase: cysM α ACP synthase: c1186 ACP synthase: c1186 Putative beta- nth 1,2-diol RecA filament- oxo-C36:2-[acp] a protein N -phospho- synthase: aroB heptulosonate- 7-phosphate reductoisomerase: semialdehyde preQ biosynthesis pfkA 3-hydroxyacyl-CoA CoA -D-ribose 1,5- thiolase: fadA thiolase: fadA [+ 4 isozymes] a [glycine-cleavage (2E)- oxo-C56:2-[acp] a 3-oxooctanoyl- L-aspartyl- 0 dehydratase: edd bisphosphatase: fbp monoester ketoacyl-ACP butanal sulfite AMP NMNH DNA complex L-histidine 3-dehydroquinate dehydrogenase: synthase: argA cyclodiphosphate isopentenyl- thiolase: [+ 2 isozymes] O-acetylserine thiosulfate bisphosphate 3-[(4-amino-6-chloro- 6 hexadecenoyl-CoA benzaldehyde an L-cysteine- selenide RcsF 4-phosphate 7-phosphate 3-dehydroquinate ilvC L-aspartyl-4-phosphate [+ 2 isozymes] 6-phosphofructokinase: dehydrogenase: α 2,2'-disulfonyl di-trans,octa-cis pseudouridine complex H protein] N glycolaldehyde pyruvate gly acetate ala [acp] synthase: aroB asp synthase: ispF diphosphate ∆- -D-ribose 1,5-bisphosphate sulfhydrylase: cysK disproportionation 1,3,5-triazin-2-yl) phthalate lipid A-core 1- synthase: c1186 peptidoglycan β 3-dehydroquinate asd N-acetyl-L- pfkB fadB a 2,3,4-saturated fadA a 2,3,4-saturated azobenzene an apyrimidinic peptidoglycan 5'-phosphate D-arabinose -D-galactose -[(R)-lipoyl]-L-lysine S-conjugate 3-dehydroquinate synthase: aroB (R)-2,3-dihydroxy- KDGP amino]benzenesulfonate a cis,cis-delta5,23-3-oxo-C42:2-[acp] a cis-delta19-3-oxo-C38:1-[acp] -undecaprenyl diphosphate acetyl-CoA (7Z)-tetradecenoyl-CoA acetyl-CoA (5Z)-dodecenoyl-CoA thymine glycol aspartate- aspartate- glutamate 2-C-methyl-D-erythritol- isomerase: idi fatty acyl CoA acetyl-CoA C- 3-oxoacyl-CoA III (rhodanese) site in DNA tetrapeptide, tetrapeptide, 3-dehydroquinate synthase: aroB 3-methylbutanoate L-aspartate- GTP [+ 2 isozymes] phosphate phosphate 3-dehydroquinate semialdehyde aspartate 2-iminobutanoate 2,4-cyclodiphosphate fructose 1,6-bisphosphate glycan chain 1 glycan chain 2 AsmA DmsD 3-dehydroquinate semialdehyde semialdehyde GTP DMAPP triacylglycerol acyltransferase: cys thiosulfate a cis,cis-delta15,33- dehydratase: aroD dehydrogenase: kinase: lysC 2,3-dihydroxy- acetylglutamate Macromolecule Modification DHAP 3-oxo-(9Z)-octadecenoyl-CoA 3-dehydroquinate dehydrogenase: asd 1-hydroxy-2- cyclohydrolase 2-keto-3- degradation fadI 3-oxo-C52:2-[acp] PliG 3-dehydroquinate asd [+ 2 isozymes] isovalerate homoserine kinase: argB Putative dimethyl 3-dehydroquinate methyl-2-(E 7,8- I: folE geranyl deoxygluconate PRPP dehydratase: aroD 3-dehydroshikimate dehydratase: dehydrogenase: tRNA-uridine 2-thiolation and selenation (bacteria) aldolase: c4284 acetyl-CoA C- a triacyl-sn thiosulfate sulfoxide L-aspartate- 3-dehydroquinate dehydratase: aroD L-aspartyl- L-aspartate-semialdehyde N-acetylglutamyl- )-butenyl 4- dihydroneopterin diphosphate 6-phosphate ilvD thrA queuosine biosynthesis [+ 4 isozymes] triose-phosphate acyltransferase: -glycerol sulfurtransferase: degradation semialdehyde dehydratase: aroD triphosphate Putative adenine a [bis(guanylyl molybdopterin) a [chaperone- an apo-[c-type (1S,2R)-1- 2''-O-acetyl- a 3- a cis,cis- a [disulfide-bond Conserved 3-dehydroshikimate shikimate 4-phosphate phosphate diphosphate synthase: ispA aldolase: eda isomerase: tpiA fadI taurine degradation IV 37 (11Z)- a dipeptide with a a [protein]- guanosine 2'- 3-dehydroshikimate 2-oxobutanoate 3-methyl-2- glpE [bis-MGD cofactor a peptidoglycan an [oxidized an adenosine a D-aminoacyl- a peptide with a 5'-deoxyadenosine L-cysteinyl-glycine Apo-GcvH (R)-lipoate myristoyl-CoA D-lactaldehyde formate (2S, 3S)-3- LapB dehydrogenase: homoserine synthase: ispG lipase: phosphoribosyltransferase: apt dimethyl sulfoxide cofactor chaperone]- a cis,cis-delta5,23-C42:2-[acp] a malonyl-[acp] a cis-delta15-C34:1-[acp] a malonyl-[acp] ADP]-[disordered- cytochrome] ser C-(indol-3- DMAPP a tRNA precursor hexadecenoyl-CoA thr C-terminal L-proline ADP-ribose L-histidine oxodocosanoyl- CTP delta13,25-3- carrier protein] asp lys hypothetical homoserine geranyl cys 3-ketoacyl-CoA acetyl-CoA chaperone]-bis-MGD DsbA protein] in tRNA [tRNA] leader sequence monophosphate methylaspartate YraP shikimate 3-dehydroshikimate aspartate- oxobutanoate 4-hydroxy- homoserine dehydrogenase: N-acetylglutamylphosphate isopentenyl- preQ c4836 thiosulfate- S-sulfanyl-L-cysteine form scaffold with reduced L- yl)glycerol Putative acyl-coa Putative acyl-coa (R)- protein- [acp] hydroxyC44:2- with reduced L- protein aroE dehydrogenase: Acetolactate 1-hydroxy-2-methyl- 0 threonine 3-oxoacyl- Asparagine dehydrogenase: shikimate semialdehyde tetrahydrodipicolinate dehydrogenase: thrA metL reductase: argC diphosphate 7-cyano-7- D-glyceraldehyde 3-phosphate thiolase: fadA a 1,2-diacyl- sulfurtransferase: taurine dehydrogenase: dehydrogenase: lactaldehyde histidine cysteine residuesprotein thrA 2-(E)-butenyl diphosphate:NAD(P)+ diphosphate protein] complex cysteine residues 3-phosphate 2''-O-acetyl- [ACP] [acp] 3-oxoacyl- synthetase shikimate shikimate dehydrogenase: dehydrogenase: synthase 2-isopropylmalate valine synthase: dapA 6-carboxy-5,6,7,8- farnesyl L-cysteine:[protein sn-glycerol ygaP α-ketoglutarate- lysozyme: cysteinylglycine dehydratase: tdcB Xaa-Pro lipoate-apo- CTP disulfide aroE homoserine N-acetyl-L- 4-diphosphate oxidoreductase: ispH deazaguanine (7Z)-hexadecenoyl-CoA dimethyl sulfide β β tRNA D-aminoacyl- leader 5'-deoxyadenosine c2464 c2464 reductase: autokinase: [ACP] dehydrogenase: homoserine dehydrogenase: aroE isozyme synthase: leuA transaminase: tetrahydropterin cysteine] Glyceraldehyde dependent taurine bis-MGD cofactor -ketoacyl [acyl-carrier -ketoacyl [acyl-carrier rrrD RNase D threonine dipeptidase: GcvH protein ADP-ribose reductase: reductase: B [glutamine- shikimate asd dehydrogenase: metL L-homoserine glutamate 5- diphosphate reductase: queF inorganic tryptophan dimethylallyltransferase: peptidase: nucleosidase: mtn dipeptidase: pepN acyl-CoA acyl-CoA yahK envZ reductase: oxidase ydiB II: ilvM ilvG sulfurtransferase: 3-phosphate dioxygenase: tauD protein] synthase: fabB protein] synthase: fabB non- tRNA exonuclease: rnd deaminase: ilvA pepQ deacetylase: a (3R)-3-fabG hydrolyzing]: L-valine dehydrogenase: aroE shikimate ilvE (2S,4S)-4-hydroxy-2,3,4,5- semialdehyde synthase: ispA preQ Putative acyl-coa chaperone: fdhD synthase: [+ 3 isozymes] ligase: lplA nrdD (quinone) fluoride CrcB fluoride NapF val val dehydrogenase: L-aspartate- 1 pyrophosphatase: ppa thiocyanate sulfite chaperonin miaA deacylase: lepB dehydrogenase: dehydrogenase: ymdB [+ 3 isozymes] [+ 23 isozymes] a cis,cis-fabG asnB glt D-lysine exporter metL shikimate dehydrogenase: [+ 2 isozymes] tetrahydrodipicolinate IPP iscS dehydrogenase aminoacetaldehyde Putative beta-ketoacyl- Putative beta-ketoacyl- trpB trpA 2-oxobutanoate (R)-propane- a [protein]- hydroxydocosanoyl- a [disulfide-: dsbB guanosine ydiB shikimate semialdehyde (2S)-2-isopropylmalate N-acetylornithine (2E,6E)-farnesyl dehydrogenase: undecaprenyldiphospho- N-acetyl-D- dtd fadE fadE delta13,25-3- (S)-2-aceto-2- L-homoserine homoserine O- dimethylallyl- A: c1843 ACP synthase: c1186 ACP synthase: c1186 molecular N-phospho- [acp] bond carrier asn dehydrogenase: ydiB 4-hydroxy- aminotransferase: L-cysteine tRNA-guanine a 2-acylglycerol 6 5-deoxy-D-ribose (2E,11Z)-hexadec- a [glycine-cleavage (2E)-tetradec- 1,2-diol 7-carboxy-7- diphosphate c2464 phosphate sulfo-bis(guanylyl a [bis(guanylyl N-acetylmuramoyl-L- glucosamine chaperone N -(3-methylbut- a proteinogenic dCTP oxo-C44:2-[acp] shikimate shikimate L-homoserine ydiB homoserine hydroxybutanoate (2S)-2- val L-histidine biosynthesis succinyltransferase: diphosphate:NAD(P)+ desulfurase: sufS transglycosylase: tgt glyceraldehyde- D-glyceraldehyde adenine a nucleoside 5'- 2,11-dienoyl-CoA pro complex H protein] N 6 2-enoyl-CoA L-histidine protein] carrying tetrahydrodipicolinate argD isopentenyl- acyl-CoA molybdopterin) cofactor alanyl-γ-D-glutamyl-meso 2-en-1-yl)- a tRNA cys gly ADP-D-ribose shikimate dehydrogenase: metA oxidoreductase: ispH deazaguanine 3-phosphate molybdopterin) cofactor ATPase: hscA an apo-[c-type 3-phosphate trp a leader sequence a peptide monophosphate amino acid acetate a disulfide bond copper/ kinase: aroL Ketol-acid isopropylmalate reductase: dapB [+ 2 isozymes] an [L-cysteine desulfurase]- a 7-aminomethyl-7- a [reduced 37 an uncharged -[(R)-lipoyl]-L-lysine KpsE shikimate diphosphate ∆- 7-cyano-7- ditrans,polycis all-trans- dehydrogenase: chaperone]-L-cysteine -2,6-diaminopimeloyl- cytochrome] with adenosine Ag + silver Ag + PqqL homoserine shikimate thrA reductoisomerase: hydro-lyase (2- homoserine O- homoserine cys deazaguanosine 34 dehydrogenase: gapA a cis,cis-delta7,25-3-oxo-C44:2-[acp] a cis-delta17-3-oxo-C36:1-[acp] DsbA protein] a D-amino acid Shikimate shikimate ATP PRPP bicarbonate S-sulfanyl-L-cysteine tRNA + + kinase: aroL succinyltransferase: kinase: thrB N-acetyl-L- isomerase: idi deazaguanine -undecaprenyl- octaprenyl- fadE D-alanyl-D-alanine a dislufide bridge in tRNA Cu export Cu kinase I: aroK kinase: thrB homoserine ilvC isopropylmaleate- (S)-2,3,4,5-tetrahydrodipicolinate O-succinyl-L- in tRNA a [disordered- an [Fe-S cluster shikimate kinase: aroL ornithine synthase: queC diphosphate diphosphate IscS:TusA 13-DPG glycerol system Shikimate dehydrogenase: forming): leuC leuD metA carbamoyl superpathway of L-alanine biosynthesis tRNA preQ 34 S- (2E,7Z)-hexadecenoyl-CoA form [Fe-S] cluster biosynthesis kinase: Shikimate (R)-2,3-dihydroxy- homoserine sulfurtransferase: 1 kinase I: aroK O-phospho- ATP tetrahydrodipicolinate cys acetylornithine synthase [(2E synthase: ispB scaffold protein] chaperone]-ATP shikimate 3-phosphate aroL kinase I: aroK metL 3-methylpentanoate phosphate DMAPP preQ tusA adenosylmethionine L-homoserine phosphoribosyltransferase: succinylase: dapD O-phospho-L-homoserine 0 ,6E)-farnesyl- phosphoglycerate enoyl-CoA 2-isopropylmaleate deacetylase: 3-methyl-2- + + PqiC thr RhtC thr 2,3-dihydroxy-3- synthetase: all-trans- ribosyltransferase- Na ChaA Na shikimate 3-phosphate 3-phosphoshikimate 1- Shikimate L-homoserine hisG O-succinyl-L-homoserine O-succinylhomoserine(thiol) diphosphate a [TusA sulfur-carrier protein]- kinase: pgk hydratase: fadB threonine argE carB carA oxobutanoate octaprenyl isomerase: queA GMP-N-ε-(N-α-acetyl a [protein] N- a 2,3,4- 2-[(2R,5Z)- dTDP-4-dehydro- a [protein]- kinase shikimate 3-phosphate methylvalerate (2S)-2- N-succinyl-2-amino-6-ketopimelate threonine -lyase: metB cys specific]: uppS S-sulfanyl-L-cysteine a purine base an intra- a [protein chain RNase II poly-A hydrogen D-ribulose a supercoiled a cis,cis-delta9,21- a cis,cis- a mismatched carboxyvinyltransferase: synthase: valine 34 enoyl-CoA β MoO - F6P a [reduced a pectate a RNA-DNA hybrid palmitoleoyl-CoA β-aspartyl dipeptide a reduced formate 3-hydroxy- 3-phosphoshikimate 1- hydro-lyase: ilvD isopropylmalate carbamoyl- diphosphate an epoxyqueuosine 3-phospho-D-glycerate fatty acid -oxidation lesion in DNA a cis,cis-delta7,19-C38:2-[acp] a malonyl-[acp] a cis-delta13-C32:1-[acp] a malonyl-[acp] 2 protein disulfide lysine methyl ester) (R)-β-lysine elongation factor a PII protein terminal-formyl- saturated (3R)-3- a behenoyl-[acp] 5-phosphate duplex DNA 3-hydroxyC40:2- delta15,27-3- (2-carboxy-4- 2,6-dideoxy- S-hydroxy- aroA thrC I: aroK synthase: thrC L-ornithine TusA:TusD hydratase: fadJ GTP DsbD protein] dATP substrate mRNA peroxide thioredoxin UTP DNA base pair L-kynurenine 3-phosphoshikimate 1- 1-(5-phospho-β-D-ribosyl)-ATP N-succinyldiaminopimelate transaminase: in tRNA III (unsaturated, molybdopterin 5'-phosphoramidate 34 UTP L-methionine Putative acyl-coa hydroxyacyl-CoA D-ribulose 5- Replicative methylthiazol-5(2H α-D-threo- L-cysteine Hypothetical carboxyvinyltransferase: homoserine O- (S)-3-methyl-2- hydro-lyase (2- O-succinylhomoserine(thiol) phosphate di-trans,octa-cis sulfurtransferase: molybdopterin P]-L-lysine Putative 3- 2,3,4-saturated [acp] 3-oxoacyl- hydroxyC46:2- methyl- Na + MdfA Na + 5-enolpyruvyl- shikimate 3- carboxyvinyltransferase: aminotransferase: argD L-cystathionine ilvE Probable (S)-3-hydroxy-(7Z) odd number) cofactor pyrophosphohydrolase: dehydrogenase: phosphate 1- DNA )-ylidene]ethyl hexopyranose protein ygdQ aroA thr succinyltransferase: oxopentanoate isopropylmaleate- -lyase: metB L-cysteine:[protein -undecaprenyl tusB tusC tusD epoxyqueuosine DNA- Putative hydroxyacyl-CoA fatty acyl- [ACP] [acp] 3-oxoacyl- directed HdeB shikimate 3-phosphate phosphate aroA phosphoribosyl-ATP thr geranyl -hexadecenoyl-CoA Fructose-6- thiol- nudB isoaspartyl dehydrogenase: UTP forming): leuC leuD N-succinyldiaminopimelate ornithine pyruvate diphosphate phosphoglycerate phosphoglycerate a (3Z)-alk-3- β-ketoacyl [acyl-carrier β-ketoacyl [acyl-carrier exopolygalacturonate purine nucleoside EF-P-lysine [protein-PII] peptide RNase: c2464 exoribonuclease [acp]:NAD+ helicase: reductase: [ACP] mismatch phosphate 5-enolpyruvyl- metA isoleucine cysteine] val diphosphate a [TusD sulfur-carrier protein]- reductase: queG formamidopyrimidine phosphate dehydrogenase: dipeptidase: reductase: chorismate 3-phosphoshikimate 1- 5-enolpyruvyl- pyrophosphatase: hisI aminotransferase: serC undecaprenyl mutase 2: gpmB mutase: gpmA 3-hydroxyacyl-CoA enoyl-CoA bis(molybdenum disulfide phosphoramidase: deformylase: rnhB nucleoside triphosphate acyl-CoA II: rnb yajO dnaB reductase: repair: shikimate 3-phosphate threonine cys transaminase: (2R,3S)-3- carbamoyltransferase: sulfurtransferase: S-sulfanyl-L-cysteine 34 dodecenoyl- glycosylase: mutM protein] synthase: fabB protein] synthase: fabB lyase: c0323 lysyltransferase: uridylyltransferase: c2467 iadA oxidoreductase: 1-deoxy-D- a cis,cis-fabG a [protein]- Li + Li + carboxyvinyltransferase: L-cystathionine Cystathionine biosynthesis a queuosine dehydrogenase: cofactor) aldolase exchange: pyrophosphohydrolase: a 2,3,4-saturated nrdD dTDP-4-dehydro- 3-hydroxy- synthase: shikimate 3-phosphate argI pyrophosphate 2,3-bisphosphoglycerate- hinT glnD def dehydrogenase: fabI [+ 2 isozymes] a cis,cis-fabG mutL 2-(2-carboxy-4- + NhaA + dehydratase: ilvE isopropylmalate β glutamate--pyruvate iscS TusD:TusE in tRNA CoA D- Putative beta-ketoacyl- Putative beta-ketoacyl- 1: mipB epmA xylulose 5- delta9,21-3- L-cysteine Na Na chorismate aroA O-succinyl-L- 1-(5-phospho- -D-ribosyl)-AMP N-succinyl-L,L-2,6-diaminopimelate beta-lyase: metC independent fadB synthase: mobA dsbD mazG fadE 3-oxoacyl-CoA a (2E)-docos- a single delta15,27-3- mutS mutH 2,6-dideoxy- D-kynurenine aroC L-cysteine valine--pyruvate phosphatase: IPP isomerase: ACP synthase: c1186 ACP synthase: c1186 4-(4-deoxy- RNase II phosphate oxo-C40:2-[acp] a properly methylthiazol-5- FtsP synthase: tdcB 5-enolpyruvyl- chorismate homoserine 3-isopropylmalate [+ 2 isozymes] aminotransferase: alaA sulfurtransferase: a [DNA]- fructose-6- a nucleoside 5'- (2E,9Z)- stranded DNA β-L-galactose YobD succinyl- ybjG geranyl phosphoglycerate 3-hydroxyacyl-CoA a 5'-phospho- a modified α a pectate DNA dAMP a proteinogenic AMP 2-enoyl-[acp] an oxidized H O dUTP oxo-C46:2-[acp] yl)ethyl phosphate threonine synthase: ile dehydrogenase: phosphoribosyl-AMP Cystathionine glutamate--pyruvate desulfurase: aminotransferase: tusE fadJ nucleotide- 4-oxo-2-pentenal two reduced -D-galact-4- [a protein chain an N-terminal L- substrate with 2 matched aroC chorismate shikimate 3- L-citrulline diphosphate mutase: gpmM dehydrogenase: [DNA] nucleobase bis(guanylyl phosphate N-α-acetyl lysine a uridylylated formate monophosphate hexadecenoyl-CoA asp thioredoxin aroC cyclohydrolase: hisI diaminopimelate L-cysteine biosynthesis sufS avtA [+ 2 isozymes] ∆ 3 2 Secondary Metabolite Degradation an [oxidized enuronosyl)-D- elongation factor amino acid no poly-A tail DNA base pair deaminase: phosphate leuB beta-lyase: metC 2-aminoprop- aminotransferase: alaC a [TusE sulfur carrier -cis-∆ anhydromuropeptides recycling I 3'-phosphate aldolase: fsaB cysteine residues GMP methionyl-[protein] Na + NhaB Na + gln O-succinylhomoserine(thiol) desuccinylase: dapE VI (from L-methionine) di-trans,octa-cis synthase: ispA 34 fadJ 4-deoxy-L-threo-hex-4- superpathway of D-glucarate molybdopterin) methyl ester PII protein chorismate ilvA 1-(5-phospho-β-D-ribosyl)- [+ 2 isozymes] L-homocysteine geranyl a uridine in tRNA -trans- a cis,cis-delta9,21-3-oxo-C40:2-[acp] a cis-delta15-3-oxo-C34:1-[acp] DsbD protein] in a protein galacturonate EF-P]-N-(β-L- chorismate chorismate -lyase: metB (2S)-2-isopropyl- 2-enoate -undecaprenyl protein]-S-sulfanylcysteine N 6 -L-threonylcarbamoyladenosine 37 2-phospho-D-glycerate enopyranuronate degradation and D-galactarate degradation cofactor chorismate anthranilate Argininosuccinate 3-oxo-(7Z)- GlcNAc-1,6-anhMurNAc- lysyl)-L-lysine 34 (2Z)-2-aminobut- synthase: 3-oxosuccinate 5-[(5-phosphoribosylamino) diphosphate enoyl-CoA mutase: tyrA synthase: L,L-diaminopimelate synthase: argG ala phosphate -modified tRNA biosynthesis hexadecenoyl-CoA L-Ala-γ-D-Glu-DAP-D-Ala 4-deoxy-L-threo-hex- D-glyceraldehyde aroC methylideneamino]imidazole- met cobalamin- isomerase: dihydroxyacetone anthranilate trpE trpD 2-enoate chorismate tRNA-specific enolase: eno D-glucarate 3-phosphate Syd chorismate 4-carboxamide L-homocysteine 2-aminoprop-2-enoate S-adenosylmethionine independent methionine L-arginino- acetyl-CoA C- fadB 4-enopyranuronate Putative synthase: mutase: tyrA L-cystathionine 2-thiouridylase: a (2E)-2- mutase: pheA Putative chorismate diaminopimelate synthetase: c4547 synthase: thr acyltransferase: 1,6-anhydro-N- Na(+)/H(+) trpE trpD chorismate 1-(5-phosphoribosyl)-5- homocysteine 2-iminopropanoate succinate mnmA Na + Na + 4-methyl-2- epimerase: dapF metH fadI enoyl-CoA acetylmuramoyl- exchanger anthranilate [(5-phosphoribosylamino) cobalamin- methionine transmethylase: Fatty Acid and Lipid Biosynthesis threonylcarbamoyl- phosphoenolpyruvate Glucarate a 2-oxo N-acetyl-β- arbutin-6- a 2'- (7Z)- 32 an [RNA]-3'- a cis,cis-delta9,27- a cis,cis-delta7,25- a cis,cis- a DNA with D-myo- chorismate mutase: pheA argininosuccinate ketogluconate metabolism an organic a [protein]- + a uridine a dipetide with an N- 2-phospho- Putative synthase: Cystathionine oxopentanoate methionine adenosyltransferase: L-alanine a uridine in tRNA a 2,3,4-saturated 2- a 2,3,4-saturated H O ATP L-cysteine H bicarbonate RNA H O a 3-oxohexacosanoyl- ATP an mRNA yjcE prephenate methylideneamino]imidazole-4- independent metE AMP synthase: tsaC 3-ketoacyl-CoA 5-dehydro-4-deoxy- dehydratase SAM a cis,cis-delta9,27-C46:2-[acp] a malonyl-[acp] a cis-delta9-C28:1-[acp] a malonyl-[acp] carboxylate met 2 hydroperoxide L-cysteine neuraminate phosphate cys deoxyribonucleoside tetradecenoyl-CoA in tRNA terminal L-aspartate a cerotoyl-[acp] 2 2 ribonucleoside- 3-hydroxyC46:2- 3-hydroxyC44:2- delta11,23-3- unresolved a protein inositol (2,4,5) D-glycerate anthranilate 2-iminobutanoate mutase: tyrA lyase: argH a 2-thiouridine 34 in tRNA (L-threonylcarbamoyl) amidase: ampD D-galactarate fatty acyl-[acp] desulfurase [DNA] XTP [acp] c2419 prephenate beta-lyase: metC leucine carboxamide isomerase: hisA meso-diaminopimelate homocysteine synthase: metH metK pyruvate kinase: pykA thiolase: fadA D-glucuronate related lysophosphatidate 5'-triphosphate Putative acyl-coa 3'-phosphate [acp] [acp] hydroxyC42:2- recombinational trisphosphate synthase: chorismate 2-iminopropanoate methionine superpathway of fatty acids biosynthesis (E. coli) adenylate phosphoenolpyruvate 2,5-didehydro- tRNA Um32 2,3,4-saturated RNA 3'- 3-oxoacyl- 3-oxoacyl- 3-oxoacyl- Putative YbjL [+ 2 isozymes] transaminase: transmethylase: metE SAM superpathway of lipopolysaccharide biosynthesis cyclopropane biotin-carboxyl carrier Pyruvate protein: ygcY xanthosine triphosphate dehydrogenase: [acp] or Holliday Putative phosphoribulosylformimino- synthase: 6 synthetase: ppsA N-acetyl-β-D- γ D-gluconate 5-dehydro- N-acetylneuraminate methyltransferase: fatty acyl- terminal [ACP] [ACP] [ACP] 3-oxoacyl- disulfide c2419 prephenate prephenate mutase: pheA prephenate arg fatty acid (CFA) protein assembly 5-carboxymethylaminomethyluridine- N -L- kinase I: pykF (5Z)-tetradecenoyl-CoA L-Ala- -D-Glu- tRNA 3-amino-3- RNA lipid arbutin 6- carbonic pyrophosphatase: rdgB hydrogen:oxygen poly(A) Na(+)/H(+) ilvE pyruvate Glucarate methionine- cysteine DNA c2464 dipeptidase: Ribonuclease [ACP] junctions, + + anthranilate AICAR-P diaminopimelate methionine metH a (3R)-3- threonylcarbamoyladenine glucosamine(anhydrous) meso-DAP-D-Ala 4-deoxy-D- galactarate β-ketoacyl [acyl-carrier β-ketoacyl [acyl-carrier acyl-[acp]:1-acyl- lyase subunit: c3639 anhydrase: trmJ [acp]:NAD+ oxidoreductase: phosphate reductase: reductase: reductase: polymerase: isomerase: Na Na dehydratase: dehydrogenase: dehydrogenase: 2-aminoprop- acetyl-CoA biosynthesis a [carboxyl-carrier tRNA synthase: mnmE mnmG carboxypropyltransferase: oxo-acid helicase: dbpA hydroperoxide phosphate nucleoside triphosphate a 2'-O- pepE PH: rph exchanger prephenate proline biosynthesis I leucine decarboxylase: lysA synthase: metH acyl-CoA -N-acetylmuramate 2,5-diketo- 2,5-diketo- glucuronate dehydratase: dehydratase: protein] synthase: fabB protein] synthase: fabB sn-glycerol-3- β desulfurase: polymerase: acyl-CoA oxidoreductase: an [RNA]-3'-cyclase: rtcA fabG fabG fabG reductase: created by RecADNA c3787 D-myo- pheA tyrA tyrA L-homocysteine hydroxytetradecanoyl- UDP-N-acetyl- a [phospholipid] biotin carboxyl- 6 synthase: tsaD tsaB tsaE pyruvate L,D- tapT RNA peroxidase: tpx N-acetyl- - glucohydrolase: can pyrophosphohydrolase: 32 hyaC hyaB hyaA a (3R)-3- a cis,cis- a cis,cis- pcnB D-glycerate yjcE anthranilate 2-oxobutanoate 2-enoate protein dimer]-N a 5-carboxymethylaminomethyl- 6 ygcX transaminase: iscS dinB dehydrogenase: methyluridine a cis,cis-fabG helicase: Putative aminotransferase: imidazole glycerol met acetyl-CoA [acp] α-D-glucosamine carrier protein an N -L- dehydrogenase: glcNAc-1,6- D-gluconate D-gluconate isomerase: garD Putative beta-ketoacyl- Putative beta-ketoacyl- phosphate 2-O- neuraminate fabI ribonucleoside-2',3'- hydroxyhexacosanoyl- delta9,27-3- delta7,25-3- a peptide inositol (2,5) prephenate pyruvate olefinic fatty acid -carboxybiotinyl- 2-thiouridine 34 in tRNA carboxypeptidase: ybdL helicase: rhlB [+ 2 isozymes] bglA mazG in tRNA anthranilate 4-hydroxyphenylpyruvate tyrB phosphate lys met carboxyltransferase: cyclopropane biotin- threonylcarbamoyladenine 37 fadE anhMurNAcaminidase: reductase: reductase: kduI acyltransferase: fadE a (2E)-hexacos- cyclophosphate delta11,23-3- recG bisphosphate ACP synthase: c1186 ACP synthase: c1186 lyase: nanA [acp] oxo-C46:2-[acp] oxo-C44:2-[acp] a DNA segment + + Putative 2-oxo-3- Acetolactate dehydratase: cobalamin- glt L-lysine 5-aminomethyl- ldcA S-methyl-5'- a 3-[(3S)-3-amino- [+ 2 isozymes] XMP (2E,7Z)- a proteinogenic a nucleoside oxo-C42:2-[acp] Na YcgO Na UbiB 4-hydroxyphenylpyruvate synthase: synthase: hisF hisH SAH accD accA acyl-[acyl-carrier- fatty acyl [acetyl-CoA- in tRNA 2-trans,5-cis- nagZ dkgB c0417 c0414 5-dehydro-4- plsC an S-sulfanyl- CO H O RNA 2-enoyl-[acp] H O an mRNA phenylpropanoate methionine 3-deoxy-D-glycero- 3-carboxypropyl]- 2 2 asp 2 anthranilate c2419 synthase pheA tyrosine independent glutamate leu phospholipid carboxylase] 2-thiouridine L-alanyl-γ-D-glutamyl- deoxy-D-glucarate thioadenosine 2-oxo-4- an intra- [DNA] tetradecenoyl-CoA amino acid diphosphate synthase: D-ribulose 5-phosphate protein]--UDP-N- tetradecadienoyl-CoA 1,6-anhydro-N- 2,5-diketo- 2,5-hexodiulosonate uridine in tRNA a proteinogenic ADP H + an alcohol N-acetyl-β-D- ala [L-cysteine synthase: phenylalanine tyrosine isozyme aminotransferase: homocysteine 5-kinase: L-cysteine biosynthesis I malonyl-CoA ligase: birA synthase: mnmC meso-diaminopimelate methylthiobutanoate phosphate β-D-glucose anthranilate 2-oxo-3- 2-iminopropanoate D-erythro-imidazole- S-adenosylhomocysteine acetylglucosamine O- a [phospholipid]synthase: cfa a biotinylated acetyl-β-muramate α-dehydro- amino acid protein disulfide pyruvate desulfurase] c2419 II: ilvM ilvG aspC transmethylase: metH AICAR D-gluconate 2-keto-D-gluconate 2-keto-3-deoxy- a cis,cis-delta11,29-3-oxo-C48:2-[acp] a cis-delta11-3-oxo-C30:1-[acp] mannosamine benzene-1,4-diol 2+ 2+ transaminase: aminotransferase: proB D-arabinose ∆ 3 2 a 2,3,4-saturated 1,2-diacyl- 6-phosphate Co Co phosphoribosyl phenylpropanoate L-glutamate superpathway of L-aspartate glycerol-phosphate nucleosidase: mtn acyltransferase: lpxA fatty acid containing [BCCP monomer] a 5-(aminomethyl)-2- -cis-∆ -trans- enoyl-CoA β-deoxy-D CorA metE L-cysteine biosynthesis VII (from S-sulfo-L-cysteine) [acyl-carrier-protein] S anhydro-N- reductase: D-gluconate 2+ 2+ anthranilate aspC aspC [+ 2 isozymes] tyrosine selenocysteine 5-phosphate thiouridine 34 in tRNA sn-glycerol 3-phosphate Mg Mg indole Mtr indole transferase: trpD phenylalanine 5-phosphate and L-asparagine biosynthesis ser -malonyltransferase: cyclopropane enoyl-CoA hydratase: fadB acetylmuramic dkgA -glucarate phosphoribosyl [+ 2 isozymes] tyrosine (S)-2-aceto-2- aminotransferase: methionine imidazoleglycerol- superpathway of L-serine biosynthesis I (bacteria) S-ribosyl-L- isomerase: dehydrogenase: N-(5-phosphoribosyl) transaminase: fabD UDP-3-O-[(3R)-3- 5-methylaminomethyl- isomerase: fadB enoyl-CoA acid kinase: anmK 2,5-diketo- superpathway of hexuronide aldolase: garL transferase: trpD tyrB glutamate-5- phosphate and glycine biosynthesis I homocysteine gutQ kduD aminotransferase: hydroxybutanoate aspC synthase: ser serine hydroxymyristoyl]-N- 2-thiouridine-forming -anthranilate glt hydratase: fadJ D-gluconate and hexuronate degradation di-trans,octa-cis 2+ 2+ semialdehyde dehydratase: hisB β N-acetyl-muramoyl-(L- α ε α a palmitoyl-[acp a cis,cis-delta7,19- a cis,cis- UDP-2-acetamido- ω N-acetyl-D- N-(5-phosphoribosyl) phe tyrB Ketol-acid metH pyruvate fumarate 3-phospho- sec acetyl-α-D-glucosamine N-acetyl- -muramate 2-keto-L-gulonate 2-dehydro-3- tartronate semialdehyde UDP-α-D-glucose N ,N -diacetyl-lysyl- a [lipoyl-carrier a CDP- a [protein]- - 4 a siderophore- an aromatic a monocarboxylic 3-phospho- Co Co [+ 2 isozymes] ser a tRNA acetyltransferase: a malonyl-[acp] D-arabinose methyltransferase: 3-trans,5-cis- reductase: β a 5,10- a uridine 34 -undecaprenyl pristanate 1-palmitoylglycerol γ pyruvate (R)-lipoate ADP cis-vaccenoyl-CoA N -acetylcytidine L(or D)-O- a 3-oxotetracosanoyl- N - YbeX branched chain dehydrogenase: S-ribosylhomocysteine a biotinylated Metabolic Clusters 6-phosphate a -D- deoxy-D-gluconate gly a cis,cis-delta9,21-C40:2-[acp] a malonyl-[acp] a myristoyl-[acp] alanyl- -D-glutamyl-L- a tRNA precursor D-alanyl-D-alanine a peptide protein]-L-lysine diacylglycerol L-glutamate domain within a bound Fe(III) 3-hydroxyC38:2- delta17,35-3- acid amide 2,6-dideoxy- glucosamine D-glycerate Mg 2+ Mg 2+ ile ile -anthranilate reductoisomerase: tyr D-glycerate selenide serine cysE 5-phosphate UDP-3-O-acyl-N- mnmC tetradecadienoyl-CoA 3-phosphate IMP phosphoserine [acp] amino acid phosphocreatine proA imidazole acetol-phosphate D-3- lyase: luxS [BCCP dimer] acetyl-CoAbiotin 3-hydroxy-5-cis- ghrB glucuronoside tartronate methylenetetrahydrofolate in tRNA phosphate lysyl-D-alanyl-D-alanine) 2'-deoxyadenosine 5'- Putative acyl-coa chemotaxis protein fatty acid synthase] [acp] hydroxyC54:2- Putative β-L-arabino- 6-phosphate val amino acid / val tyr ilvC met acetyltransferase: acetylglucosamine N-acetylmuramic 2-keto-L- 2-dehydro-3- Putative beta- 3-oxoacyl- aromatic- 3-oxoacyl- phe aspartate aspartate phosphoglycerate Putative beta- isomerase: carboxyltransferase:carboxylase: a 5-[(methylamino)methyl]- acyl-CoA tetradecenoyl-CoA semialdehyde diphosphate:oxidized dehydrogenase: inosine-5'-phosphate Phosphoserine [acp] amidase: hex-4-ulose phenylalanine 1-(o- deacetylase: lpxC gulonate β-D- methyltransferase: 4 ketoacyl-ACP [ACP] [ACP] 3-oxoacyl- leu leu L-glutamate-5- L-serine:tRNASec selenide, cysE superpathway of fatty acid biosynthesis I (E. coli) 34 N-end rule pathway I (prokaryotic) acid 6-phosphate 2-keto-D- deoxygluconokinase: pyruvate- CDP-diacylglycerol N -acetylcytidine ferric-chelate amino-acid (R)-2,3-dihydroxy- transaminase: ammonia- histidinol-phosphate dehydrogenase: serA O-acetyl-L-serine hydrogen sulfide ketoacyl-ACP kdsD accDaccC accA 2-thiouridine in tRNA thioesterase: 3-hydroxyacyl-CoA reductase: garR short chain acyl-CoA D-alanyl-D-alanine lipoate--protein NrdH glutaredoxin-like c2464 phosphohydrolase: phosphatase: ybeM L-homocysteine UDP-3-O-(3- reductase: glucuronidase: 5-carboxymethylaminomethyluridine- β UDP- acyl-[acp]:1-acyl- D-alanyl-D-alanine proline cheR [ACP] 2+ 2+ phe ABC transporter phe carboxyphenylamino) semialdehyde aminotransferase: 3-phospho- ligase (AMP- water etherase: murQ gluconate kdgK -ketoacyl [acyl-carrier synthetase: fadK endoribonuclease flavodoxin carboxypeptidase: pyrophosphatase: amidohydrolase: synthase: reductase: serB reductase: transaminase: reductase: Mg MgtA Mg 1-(o- 3-methylpentanoate aspC lyase: aspA synthase: D-arabinose leucyl- fadM dehydrogenase: ligase A: lplA protein oxidoreductase: acyl-CoA a [protein]-L- yrfG reductase: Putative -1'-deoxyribulose hydroxypyruvate forming): serS dikinase: O-acetyl-L-serine hydroxymyristoyl) ghrB reductase: uidA tRNA synthase: mnmE mnmG protein] synthase: fabB glucose:undecaprenyl- sn-glycerol-3- carboxypeptidase: aminopeptidase: cdh yqfB a 3-oxooctadecanoyl-c1186 nfeF a (3R)-3-fabG tyrB a cis,cis-fabG N-acetyl-α-D- ammonia 2,3-dihydroxy-3- hisC thiosulfate c1186 5-phosphate acetyl-CoA N-acetyl-D-glucosamine D-glycerate fatty acyl-CoA BN: rbn oxidoreductase: dacD 5 [+ 3 isozymes] UDP-2-acetamido- D-glycerate carboxyphenylamino) -α-D-glucosamine tRNA--protein fadB phosphate glucose- phosphate 2-O- dacC pepP nrdF nrdE dehydrogenase: glutamate-O an aromatic a cis,cis-fabG amidase: assimilation cycle III 5'-phosphate L-serine biosynthesis I 3-phosphoserine selD O-acetylserine a [protein] (3E,5Z)-tetradecadienoate ghrB KDGP Putative beta-ketoacyl- ydbK [acp domain within serine hydroxytetracosanoyl- delta7,19-3- β creatine glucosamine -1'-deoxyribulose methylvalerate glutathione [+ 2 isozymes] transferase: aat 6-phosphate L-idonate D-glucopyranuronate synthetase: fadD [+ 2 isozymes] -methyl-ester 2-oxo-acid delta17,35-3- c2457 2,6-dideoxy- -L- L-histidinol-phosphate aminotransferase: UDP-3-O-(3- an N-terminal [+ 2 isozymes] glycerate 2- ACP synthase: c1186 1-phosphate acyltransferase: a [lipoyl-carrier fadE inosine a fatty acid synthase] [acp] oxo-C38:2-[acp] 1-phosphate leucine / L- hydro-lyase: ilvD L-glutamate asp an L-seryl- sulfhydrylase: cysM a 5-methylaminomethyl-2-(S- N-terminal L- galactitol degradation CMP dADP (2E,11Z)- cytidine lyxo-4-hexulose 5'-phosphate S-sulfo-L-cysteine hydroxymyristoyl) acetyl-CoA arginyl-[protein] N-acetylglucosamine- 34 transferase: wcaJ plsC 6 2+ oxo-C54:2-[acp] L-fucose FucP L-fucose leu leu 3-phospho- (S)-1-pyrroline- serC sec selenophosphate O-acetylserine acetyl-CoA:ACP geranyl)thiouridine 34 in tRNA leucyl-L-arginine 3-keto-5-cis- L-idonate 5- kinase: glxK a 5-carboxymethylaminomethyluridine N-acetyl-muramoyl-(L- a single-stranded protein]-N -[(R a phosphatidate acetate Fe a siderophore a monocarboxylate phenylalanine glt (S)-3-methyl-2- biosynthesis II [tRNA ] oxidized an acetoacetyl-[acp] 6-phosphate 2-keto-3- a 7,8-dihydrofolate α ε a proteinogenic octadecenoyl-CoA phe phe ammonium D-glycerate 5-carboxylate histidinol- L-cystathionine synthase: cysM D-arabinofuranose glucosamine N- transacylase: fabH carboxyltransferase: tetradecenoyl-CoA dehydrogenase: sulfoquinovose degradation I glycerate 2- in tRNA alanyl-γ-D-glutamyl- D-alanine mature tRNA oligoribonucleotide acetyl-CoA CO a reduced N ,N -diacetyl- a peptide )-lipoyl]-L-lysine ABC transporter D-3- Asparagine glutaredoxin sulfhydrylase: cysK AMP pristanoyl-CoA diphosphate 2 (1S,2R)-1-C-(indol-3- oxopentanoate 3-phospho- acyltransferase: accD accA deacetylase: nagA deoxygluconate galactitol lysyl-D-alanine D-alanine amino acid Pyrroline-5- synthetase phosphatase: hisB 5-phosphate 3-ketoacyl-CoA idnD kinase: garK a cis,cis-delta11,23-3-oxo-C42:2-[acp] α-D-glucopyranosyl- UMP L-lysyl-D-alanine) flavodoxin phosphoglycerate 2-oxoglutarate L-serine selenocysteine acetoacetyl- lpxD leucyl- 6-phosphate α 1-palmitoyl-2-myristoyl yl)glycerol 3-phosphate isoleucine thiolase: fadA aldehydo-D- aldehydo-D- 1-(6-sulfo- -D- diphosphoundecaprenol Putative (1S,2R)-1-C-(indol-3- glutamine dehydrogenase: serA Putative glutamate carboxylate B [glutamine- O-succinylhomoserine(thiol) [acp] 3-deoxy- UDP-2,3-bis[O-(3R)- tRNA--protein D-glucosamine 6-phosphate phosphatidate transaminase: alanine 3-phospho- histidinol Phosphoserine synthase: selA S-sulfo-L-cysteine a glutaredoxin dithiol cys an acetyl-[acp] a 5-methylaminomethyl- 5-dehydro-D-gluconate galacturonate glucuronate aldolase: eda quinovosyl)glycerol 2-phospho-D-glycerate phe PheP phe yl)glycerol 3-phosphate synthetase: glnA dehydrogenase: reductase: hydrolyzing]: asnB -lyase: metB reductase: D-manno- malonyl-CoA transferase: aat a [protein] acetyl-CoA C- L-fucose L-fucose L-fucose ilvE racemization phosphatase: 3-hydroxymyristoyl]- 2-(Se-phospho) an N-terminal D-glucuronate indoleglycerol hydroxypyruvate c0018 proC octulosonate N-terminal L- acyltransferase: phosphoglucosamine D-galacturonate permease asparagine an L- fabG α-D-glucosamine 34 D-glyceraldehyde galactitol 1- 3+ indoleglycerol phosphate 3-phosphoserine histidinol serB [acyl-carrier-protein] S selenouridine in tRNA tRNA processing L-lysyl-[protein] leucyl-L-lysine mutase: glmM isomerase: uxaC isomerase: ferric-[N-(2,3- a precursor of a 2'- Fe -[N-(2,3- a debranched a 5,6,7,8- (5Z)- an apo-[c-type D-erythrose a double- a cis,cis-delta5,23- a cis,cis- dTDP-4-dehydro- D-myo- glt synthetase: asnA selenocysteinyl- cys S-sulfo-L-cysteine 8-phosphate UDP-2,3- fadI 3-phosphate pyruvate an acyl-[acyl- a [disordered-form [Fe-S] an S-sulfanyl-[L- 1-cis-vaccenoyl-sn- an oxidized (R)-lactate 1-palmitoylglycerol a CcmH- formyl-CoA GDP-α-D-glucose GDP DHAP a dipeptide indole-3-acetamide an [oxidized maleate phosphate aldolase: trpA ile aminotransferase: dehydrogenase: hisD a (3R)-3- -malonyltransferase: 5-keto-D- uxaC phosphate a palmitoleoyl-[acp] a palmitoyl-[acp] dihydroxybenzoyl)-L- large subunit of deoxyribonucleoside dihydroxybenzoyl) oxalate α-limit dextrin cytochrome] with a malonyl-[acp] 4-phosphate a malonyl-[acp] 3-hydroxyC42:2- delta17,29-3- 6-deoxy-α-D- inositol (2,5) gln L-glutamate ala pro [tRNA sec ] reductase: grxA synthase: kdsA α a 1-lysophosphatidylethanolamine carrier protein] cluster scaffold protein] cysteine desulfurase] cytochrome c-553 CcmG disulfide [DNA] tetrahydropteridine dodecenoyl-CoA helix DNA DsbD protein] Ni 2+ Ni 2+ tyr AroP tyr aldolase: trpA glycine ser hydroxybutanoyl-[acp] diacylglucosamine a polycistronic 3-cis-dodecenoyl-CoA D-glucosamine 1-phosphate gluconate 5- D-tagaturonate 6-sulfo- -D-quinovose glycerol-3-phosphate 3-phosphate serine trimer] complex hydrogenase 3 5'-triphosphate -L-serine] complex 2'-deoxyguanosine 5'- dihydropteridine Putative acyl-coa a dislufide bridge DNA 3'-5' Putative glucopyranose bisphosphate RcnA ser alanine serC asn fabD galactitol-1- Putative beta- nonspecific [acp] 3-oxoacyl- hydroxyC48:2- thiol- 2+ 2+ biosynthesis III histidinal diphosphatase: lpxH reductase: D-fructuronate thiol:disulfide malonyl-ACP Co Co ser L-glutamate:NADP+ racemase: alr biosynthesis IV tRNA precursor N-acetylglucosamine phosphate 5- diphosphate:oxidized reductase: nfsB dehydrogenase: helicase: dipeptidase: [acp] 3-oxoacyl- amidase: (3R)- KDO-8P a 5-methylaminomethyl-2- ∆ 3 2 formyl-CoA GDP-glucose maltodextrin ketoacyl-ACP sedoheptulose [ACP] disulfide indole indole 3-phospho- 5,10-methylenetetrahydrofolate:glycine -cis-∆ -trans- glucosamine- idnO c2464 oxidoreductase: decarboxylase: uvrD ybeM oxidoreductase [+ 2 isozymes] a malonyl-[acp] 34 degradation II D-mannonate dehydrogenase: acyl-[acp]:1-acyl- Putative lactate acyl-[acp]:1-acyl- thiol:disulfide ferric-chelate hydrogenase DNA ferric-chelate glucosyl NrdH glutaredoxin-like phosphorylase: dihydropteridine synthase: pepD reductase: [ACP] exchange: 2-oxoglutarate L-serine L-asparaginase: histidinal cys hydroxymyristoyl- lipid X selenouridine in tRNA enoyl-CoA 2-acylglycerophosphoethanolamine scaffold transferase: ccmG bisphosphate fabB D-alanine hydroxymethyltransferase: glyA 1-phosphate Gluconate 5- gatD protein oxidoreductase: reductase: hmp acyl-CoA [+ 4 isozymes] reductase: Putative tyr TyrP tyr (transaminating) glutamate thr ansA [acyl carrier 3-deoxy- ribonuclease: N-acetyl-D- oxidoreductase: 6-sulfo-D-quinovose protein for iron- sn-glycerol-3- dehydrogenase: sn-glycerol-3- oxidoreductase reductase: 3 maturation polymerase: reductase: frc hydrolase: gmm malP an apo-[c-type c1186 aldolase: fbaA an unwound a proteinogenic a cis,cis-fabG dsbD dTDP-3-dehydro- Phosphoserine dehydrogenase: hisD Putative 3- Putative beta- isomerase: fadB acetyltransferase: dehydrogenase: acyltransferase: aas nrdF nrdE a 6,7- fumarate predicted tryptophan : gltB gltD dehydrogenase: tryptophan threonine protein] lipid A rne glucosamine D-altronate uxuB keto-D-tagatose sulfur cluster phosphate 2-O- c5039 phosphate 2-O- CcmG: ccmG nfeF protease: hycI dinB nfeF dehydrogenase: cytochrome] an acetoacetyl-[acp] an acetyl-[acp] double- amino acid a cis,cis-fabG amidase: a [reduced 6-deoxy-α-D- Ins(2)P D-manno- oxoacyl-[ACP] ketoacyl-ACP dodecenoyl-CoA glmU N-acetyl-D- dihydropteridine delta5,23-3- transporter synthase: trpB synthase: trpB phosphatase: aldolase: gly dehydratase: fabZ disaccharide ribonuclease: c0321 6-phosphate assembly: iscU acyltransferase: plsC acyltransferase: [+ 3 isozymes] fadE with reduced L- delta17,29-3- c2457 DsbD protein] galactopyranose fructose fructose gdhA asp octulosonate stearate biosynthesis α α-D-glucose stranded DNA oxo-C42:2-[acp] complex ile ile glt serB ltaE his synthase: lpxB synthase: c1189 synthase: c1186 a tRNA precursor rne D-isomerase: fadJ N-acetyl- -D- glucosamine D-mannonate GDP D-glucopyranose dGDP maltotriose (2E,5Z)- D-sedoheptulose oxo-C48:2-[acp] [+ 2 isozymes] 8-phosphate II (bacteria and plants) exoribonuclease plsC a CcmG protein a CcmH protein a C terminal N-(2,3- formate oxalyl-CoA 1-phosphate cysteine residues indole-3-acetate 3-hydroxydecanoyl- glucosamine 1-phosphate kinase: nagK D-altronate a phosphatidylethanolamine (2,3- 2+ 2+ dodecenoyl-CoA 1,7-bisphosphate of Fructose val BrnQ val gly [+ 3 isozymes] [+ 2 isozymes] with a 5' N-acetyl-D- 6-deoxy-6- pyruvate a reduced Fe 32 amino- a large subunit Fe dihydroxybenzoyl) trp glt trp ser [acyl-carrier- phosphatase: lipid A disaccharide II: rnb (2E)-dodec-2-enoyl-CoA dehydratase: an S-sulfanyl-[cysteine with an internal with reduced dihydroxybenzoylserine) sulfo-D-fructose 1-cis-vaccenoyl-2-palmitoleoyl- cytochrome c-553 3 of hydrogenase 3 leu leu extension and N-acetylglucosamine- glucosamine D-mannonate desulfurase]-[disordered-form disulfide bridge cysteine residues acid peptide [DNA] -L-serine protein] yrbI an acetoacetyl-[acp] a palmitoyl-[acp] [+ 2 isozymes] uxaA D-tagatofuranose sn-glycerol-3-phosphate dipalmitoyl predicted a long 3' trailer a tRNA precursor enoyl-CoA 1-phosphate 6-phosphate dehydratase: 6-deoxy-6- scaffold protein] complex dehydratase: fabA Putative beta- 6-phosphate phosphatidate transporter KDO with a 5' hydratase: fadJ uridyltransferase: N-acetylglucosamine- uxuA sulfofructose fructose fructose trp Mtr trp ketoacyl-ACP tagatose-6- complex a (2E)-but-2-enoyl-[acp] extension and a [+ 2 isozymes] glmU 6-phosphate D-gluconate kinase: yihV 3-deoxy-manno- lipid IV synthase: c1186 phosphate of Fructose A short 3' extension UDP-N-acetyl- deacetylase: nagA 6-deoxy-6-sulfo-D- a [ThiI sulfur- a [disulfide- a [50S ribosomal β 2-dehydro-3-deoxy- (11Z)-(S)-3- a HypE hydrogenase a [protein] a cis,cis- dTDP-4-dehydro- Aminoacyl-tRNA Charging tRNA charging a 3-oxooctadecanoyl-[acp] a protein with 2-oxo-3- + -D-fructofuranose 3-hydroxy, 6-trans a 2,3,4-saturated octulosonate (S)-3-hydroxydodecanoyl-CoA α D-gluconate kinase: pfkB a uracil in tRNA 2-oxoglutarate 1-ethyladenine 2-oxoglutarate ATP H O carbamoyl- NADP a reduced β-ketovaleryl-CoA an alkylated DNA DHAP a 3-oxoicosanoyl- FMN a [reduced α long chain Cu + -D-glucosamine D-glucosamine fructose 1-phosphate carrier protein]-S- reduced L- bond carrier phenylpropanoate met subunit protein 3-chloro-D-alanine 2 L-ornithine 1-phosphate L-rhamnonate hydroxyhexadec- an arachidoyl-[acp] 3'-AMP maturation protein- (L-serine/L- a protein fatty acid delta21,39-3- 6-deoxy- -D- phe phe crotonyl- cytidylyltransferase: 3-deoxy- a 3-oxoacyl-[acp] kinase: idnK thioglycolate flavodoxin -tridecenoyl-CoA [acp] DsbD protein] polyphosphate fructose FrwD fructose AroP RNase BN 6-phosphate D-galactonate degradation D-tagatofuranose L16]-L-arginine 81 phosphate 11-enoyl-CoA Putative 3- glycerol-3- FMN glucopyranose trp trp [acyl-carrier- 3-hydroxyacyl-CoA UDP-N-acetylglucosamine 2-dehydro- sulfanyl-L-cysteine cysteine residues protein] carrying 2,3,4-saturated adenosine 3'- S-carboxamide[HypE]-S- threonine) acyl-ACP 3-oxoacyl- hydroxyC58:2- thiol- Phe c3689 D-manno- 3-oxoacyl-[ACP] D-gluconate Putative 3- phe a tRNA ribonuclease: RNase D Ribonuclease 1-carboxyvinyltransferase: 1,6-bisphosphate a disulfide bond hydroxyacyl-CoA phosphate phosphate phosphate alanyl synthetase: [acp] 3-oxoacyl- phosphatase: protein] dehydrogenase: 3-deoxy-D- 6-deoxy-6- 1-ethyladenine 2-keto-3-deoxy- hydroxyacyl-CoA fatty acyl- carboxamide protein-serine/ [ACP] disulfide 3-deoxy-manno octulosonic reductase: fabG rbn exonuclease: P protein kinase: gntK D-galactonate methionine- protein- ATP acetyl-CoA C- Putative DNA-3- dehydrogenase: dehydrogenase: aminopeptidase: yigB reductase: fabI fadB murA gluconate sulfofructose- tRNA uridine 4- 3-chloro-D-alanine Ornithine flavodoxin- L-rhamnonate [acp]:NAD+ phosphohydrolase: dehydratase: threonine aas reductase: [ACP] exchange: -octulosonate acid component: D-gluconate demethylase: pyrophosphatase: + acyltransferase: fadI aldolase: c4484 methyladenine dehydrogenase: pepN 2+ 2+ lys a tRNA Lys a (3R)-3- RNase D rnd Ribonuclease UDP-N-acetyl-α-D- 1-phosphate Tagatose- sulfurtransferase: thiI protein disulfide oxo-acid arginine dehydrochlorinase: carbamoyltransferase NADP aldolase: yfaU c2467 umpG gpsA reductase: FMN Cd ZupT Cd trp TnaB trp transferase: [+ 2 isozymes] α-D-glucosamine 2-dehydro-3- alkB ycaO glycosylase: alkA c2467 oxidoreductase: a HypE hydrogenasehypE phosphatase: a 2,3,4-saturated a (3R)-3-fabG dsbD dTDP-3-dehydro- long chain 2+ ser Phenylalanyl-tRNA a butanoyl-[acp] cytidylyltransferase: rnpA 6-phosphate bisphosphate oxidoreductase: transaminase: oxygenase: 3-ketoacyl-CoA [+ 2 isozymes] 6-trans-3-oxo- sn-glycerol Cu ser a tRNA hydroxyoctadecanoyl-[acp] exonuclease: RNase T PH: rph glucosamine-enolpyruvate deoxygluconokinase: aldolase: yihT dcyD chain I: c5348 reductase: fabI pphC a peptide a cis,cis-fabG phosphatase: an [oxidized 6-deoxy-α-D- synthetase operon kdsB waaA 6-phosphate dnaJ thiolase: fadA [+ 3 isozymes] tridecenoyl-CoA adenosine maturation fatty acyl-[acp] hydroxyicosanoyl- polyphosphate Ile Pro Cys Leu Gln Asn Tyr Thr asp Arg Met Met glu His Trp Val Gly rnd exonuclease: 3-oxododecanoyl-CoA aldolase ybdL roxA fpr (2E,11Z)-hexadec- a (2E)-icos- 3-phosphate delta21,39-3- DsbD protein] ile a tRNA pro a tRNA cys a tRNA leu a tRNA gln a tRNA asn tRNA tyr a tRNA thr a tRNA tRNA asp arg a tRNA elongator tRNA met initiator tRNA met glt a tRNA his a tRNA trp a tRNA val a tRNA gly a tRNA polynucleotide UDP-N- kdgK protein-S-cyanate [+ 2 isozymes] [acp] ybjI glucopyranose lysine--tRNA leader peptide: pheM a tRNA Ala ala β-ketoacyl- 3-oxoacyl-[acyl- (3R)- glucosamine- gatY: c4018 an alkylated CMP-KDO α-Kdo-(2->6)-lipid IV rnt phosphorylase: a tRNA precursor acetylenolpyruvoylglucosamine 2-dehydro-3-deoxy- a [ThiI sulfur-carrier a 4-thiouracil in tRNA + D-glyceraldehyde L-lactaldehyde pyruvate 2,11-dienoyl-CoA 2-enoyl-[acp] a [protein] Ser/Thr oxo-C58:2-[acp] riboflavin val val A hydroxymyristoyl- 3-sulfolactaldehyde DHAP a [disulfide-bond acetaldehyde succinate AMP diphosphate H DHAP [DNA] chloride ClcB chloride L-serine:tRNASer ligase: lysU Phenylalanyl- ACP Putative beta- carrier protein] acetyl-CoA C- 6-phosphate protein]-L-cysteine 2-oxo-4- a [50S ribosomal S-carboxymethyl- nucleobase pnp with a short reductase: murB KDGP D-galactonate [+ 2 isozymes] a protein with adenine an oxidized + met met synthase: fabF [acyl carrier acyltransferase: deaminase: carrier protein] phe succinate L-citrulline NADPH H acetyl-CoA propionyl-CoA YjeH isoleucine--tRNA proline--tRNA cysteine--tRNA leucine--tRNA glutamine--tRNA ligase (AMP- asparagine--tRNA tyrosine--tRNA threonine--tRNA aspartate--tRNA arginine--tRNA methionine--tRNA methionine--tRNA glutamate--tRNA histidine--tRNA tryptophan--tRNA lysine--tRNA valine--tRNA tRNA synthetase glycine--tRNA ketoacyl-ACP reductase: fabG L-galactonate 2-dehydro-3- a disulfide bond methylthiobutanoate subunit protein L16]- D-cysteine leu leu protein] 3' extension α nagB with reduced L- flavodoxin ligase: proS ligase: leuS forming): serS ligase: hisS ligase: trpS alpha chain: pheS [+ 3 isozymes] synthase: c1186 fadI UDP-N- -D-acetylmuramate degradation D-glyceraldehyde (3R)-3-hydroxy- ile ile ligase: ileS ligase: cysS ligase: glnS ligase: asnS ligase: tyrS ligase: thrS ligase: aspS ligase: argS ligase: metG ligase: metG ligase: gltX ligase: lysS ligase: valS ligase: glyQ glyS deoxygalactonokinase: DHAP cysteine residues dehydratase: fabZ a tRNA 3-ketoacyl-CoA 2-keto-3- 3-phosphate L-arginine 81 chloride ClcA chloride [+ 3 isozymes] RNase D F6P mannitol aldehydo-L- dgoK YddB a 3-oxohexanoyl-[acp] precursor with UDP-N- a (3R)-3-hydroxyacyl- 3-hydroxydecanoyl- exonuclease: thiolase: fadA degradation I galactonate deoxygluconate 2-dehydro-3-deoxy- 2,3-dihydroxypropane pro ProP pro Ile Pro Cys Leu Gln ser Asn Tyr Thr asp Arg Met Met Glu His Trp Lys Val Phe Gly Ala a 2,3,4-saturated fatty acyl-[acp] acetylmuramate:L- D-sorbitol degradation II an L-isoleucyl-[tRNA ] an L-prolyl-[tRNA ] an L-cysteinyl-[tRNA ] an L-leucyl-[tRNA ] an L-glutaminyl-[tRNA ] an L-seryl-[tRNA ] an L-asparaginyl-[tRNA ] an L-tyrosyl-[tRNA ] an L-threonyl-[tRNA ] an L-aspartyl-[tRNA ] an L-arginyl-[tRNA ] an L-methionyl-[elongator tRNA ] an L-methionyl-[initiator tRNA ] an L-glutamyl-[tRNA ] an L-histidyl-[tRNA ] an L-tryptophanyl-[tRNA ] an L-lysyl-[tRNA ] an L-valyl-[tRNA ] an L-phenylalanyl-[tRNA ] a glycyl-[tRNA ] an L-alanyl-[tRNA ] KDO 3-hydroxydecanoyl-[acyl-carrier protein] [acyl-carrier- a 5' extension Ribonuclease L-galactonate 6-phosphate D-galactonate 1-sulfonate an oxidized rnd decanoyl-CoA alanyl-γ-D- D-mannitol an E. coli osmoregulated a 2-methyl branched (11Z)-3- trimethylamine (2E,7Z)- 3-hydroxy, 4-trans 3-hydroxyisovaleryl- a (7Z)-3- 1-deoxy- 5-fluoro-5- a [protein]- 3-oxoacyl- transferase: protein] PH: rph oxidoreductase: aldolase: eda a phosphatidylethanolamine 7-hydroxylaurate 2-oxoglutarate 1-methyl-dAMP glutathione 7,8-dihydroneopterin NAD(P)H H + a quinone 3-oxo-palmitoyl-CoA a reduced an adenine in DNA an aryl sulfate a phenol a 9S rRNA sn-glycerol RNA an aldose [acyl-carrier-protein] 6-phosphate nitroaromatic D-xylulose deoxy-D-ribose + + RNase T glutamyl-meso- 1-phosphate periplasmic glucan (OPG) 2,3,4-saturated fatty acid oxohexadecenoyl-CoA S-sulfo-L-cysteine triphosphate N-oxide tetradecenoyl-CoA -undecenoyl-CoA a lignoceroyl-[acp] a myristoyl-[acp] 3-phosphate a protein CoA lys oxohexacos- 2'-deoxyadenosine L-tyrosine K ChaA K [ACP] waaA dehydratase: fabA dehydratase: fabA lgoD D-sorbitol 6-phosphate TorC protein compound 3' -> 5' RNA 1-deoxy- ribonuclease: exonuclease: Putative acyl-coa diaminopimelate Mannitol-1- DNA adenine Putative 3- Putative 3- 2,3,4-saturated Putative beta- acyl-CoA:sn Putative 7-enoyl-[acp]3-oxoacyl- 3'-monophosphate 1-phosphate tyrosine pro PutP pro reductase: enoyl-[acyl- D-tagaturonate D-glyceraldehyde 2-dehydro-3-deoxy-6- D-glucitol-6-phosphate NAD(P)H Protease degS lysine 2,3- D-xylulose rnt dehydrogenase: phosphate 5- methyltransferase: hydroxyacyl-CoA hydroxyacyl-CoA exonuclease: fabG carrier-protein] (3R)- a (2E)-octadec-2-enoyl-[acp] rnpA ligase: mpl 3-phosphate pyruvate 1-methyl-dAMP fatty acyl- ketoacyl-ACP -glycerol-3- crotonase: [ACP] kinase: RcsF dehydrogenase: phosphogalactonate dehydrogenase: c4986 phosphoethanolamine short chain acyl-CoA short chain acyl-CoA acetyl-CoA C- Putative 6-pyruvoyl Quinone acetyl-CoA C- yhdJ ribonuclease: dehydrogenase: dehydrogenase: nitroreductase: tatD precursor: degS aminomutase: kinase: reductase: fabI hydroxymyristoyl- c2464 reduced [acp]:NAD+ synthase: phosphate 1-O- c5023 reductase: wzc a (3R)-3- UDP-N-acetylmuramoyl- mtlD aldolase: dgoA sorbitol-6-phosphate synthetase: fadK synthetase: fadK demethylase: acyltransferase: tetrahydrobiopterin oxidoreductase: acyltransferase: fadI nfsB [+ 4 isozymes] epmB xylB dequalinium dequalinium Nucleoside and Nucleotide Biosynthesis 2,3,4-saturated fatty [acyl carrier protein] acyl-CoA transferase: opgE glutaredoxin DNA adenine rne c2467 c2467 oxidoreductase: c1186 a hydroxylamino acyltransferase: [+ 2 isozymes] (E)-2- fabG 5-fluoro-5- a [protein]- 2,3,4-saturated γ F6P 2-dehydrogenase: srlD fatty acyl-CoA fatty acyl-CoA alkB fadI qor 3-ketoacyl-CoA 4-trans-3-oxo- a nucleoside 5'- a (3R,7Z)-3- 1-deoxy-D- an aldonate ethidium ethidium pro PPIII pro hydroxyhexanoyl-[acp] α α acyl-[acp]:NAD+ dehydratase: fabZ L-alanyl- -D-glutamyl- 1: grxA synthase: ygcM methyltransferase: [+ 3 isozymes] fabI a 3-oxohexadecanoyl- group-containing plsB methylcrotonoyl- β deoxy-D-ribulose L-tyrosine MdfA -Kdo-(2->4)- - a (3R)-3-hydroxydecanoyl-[acp] fatty acyl- dehydrogenase: D-glyceraldehyde keto-D-fructose 6-phosphate undecenoyl-CoA a peptide (R)- -lysine hydroxyhexacos- xylulose 5- a drug a drug 5-(methoxycarbonylmethoxy) meso-2,6-diaminopimelate synthetase: fadD synthetase: fadD 3-ketoacyl-CoA [+ 3 isozymes] thiolase: fadA dam (S)-3-hydroxy-(7Z) a (2E)-tetracos- [acp] 1-oleyl-2-lyso- monophosphate CoA phosphate (3R)- Kdo-(2->6)-lipid IV oxidoreductase: fabI fadE pyruvate compound 2'-deoxyadenosine 1-phosphate + + superpathway of purine nucleotides de novo biosynthesis I A [acp]:NAD+ 3-phosphate an E. coli osmoregulated 6 a single- 7-enoyl-[acp] phosphate K K uridine biosynthesis thiolase: fadA an N -methyladenine -tetradecenoyl-CoA 2-enoyl-[acp] phosphatidate Putative UMP biosynthesis III inosine-5'-phosphate superpathway of pyrimidine deoxyribonucleotides superpathway of pyrimidine hydroxymyristoyl- lauroyl (3R)- oxidoreductase: periplasmic glucan with a 1,2-diacyl-sn-glycerol formaldehyde succinate 6-pyruvoyl a phenol an aryl sulfate a 5S rRNA trans-∆ 2 -decenoyl-CoA PPP an oxidized trimethylamine in DNA stranded RNA biosynthesis I adenosine nucleotides de novo biosynthesis I hydroxymyristoyl- a 2-methyl branched 2,3,4- dAMP GSSG sulfite i pro ProY pro nucleobases salvage [acyl carrier cys tetrahydropterin + outer acyltransferase: fabI phosphotidylethanolamine substituent AMP diphosphate AMP 7-hydroxylauroyl-CoA diphosphate a quinol NAD(P) acetyl-CoA myristoyl-CoA TorC protein PRPP de novo biosynthesis I [acyl carrier protein] SAM saturated fatty acyl-CoA predicted membrane UDP CTP uracil protein] lpxL prephenate an uncharged enoyl-CoA acetyl-CoA (9Z)-tetradecenoyl-CoA gln bicarbonate AIR a trans-2-enoyl-[acyl-carrier protein]dehydratase: fabZ ATP-driven protein yieC UDP reductase: dehydratase: fabZ (KDO) -(lauroyl) fatty acid a stearoyl-[acp] hydratase: fadJ 5-(carboxyamino) uracil 2 tRNA K + transporter K + precursor met met amidophosphoribosyltransferase: purF IMP nrdB nrdA peptidoglycan biosynthesis I (meso-diaminopimelate containing) Cell Structure Biosynthesis -lipid IV activation 3-hydroxydecanoyl- LeuE asp phosphoribosyltransferase: upp 3-hydroxydecanoyl- A [+ 2 isozymes] complex leu leu imidazole ribonucleotide CDP [acyl-carrier-protein] carboxy-S- dUDP UMP 34 α β carbamoyl synthase: purK [acyl-carrier- myristoyl-acyl a long-chain a 3-methyl-branched a Chi-site containing a 2,3,4-saturated (Z)-2- peptidoglycan trimethylamine (S)-3-hydroxy-(11Z) (2E)-tetradec- a (1->4)- a long-chain (3S)- (S)-2- a (1->4)- a [protein]-L- a uridine type-1 GDP- -D- of K+ 5-phospho- - gly UDP-N-acetyl- dehydratase: fabA adenosyl-L- (S)-3-hydroxydecanoyl-CoA (KDO) -lipid A a phosphatidylethanolamine a single stranded DNA methyl red a reduced octanoate β-D-ribopyranose glyoxal Cu 2+ phosphate N5-CAIR ribonucleoside- protein] carrier protein- fatty acid L-lysine degradation I Amino Acid Degradation 2 double stranded RecA 1,2-diacyl-sn- methylureidoacrylate asp DAP-DAP -octadecenoyl-CoA 2-enoyl-CoA α-D-glucan 3-hydroxyacyl-CoA α-D-glucan a dodecanoyl-[acp] met proline (ω = 180) a protein a protein transmembrane mannose D-ribosylamine α-D-glucosamine isoleucine degradation I L-threonine degradation I 2,3,4-saturated fatty acid O-ureidohomoserine N-oxide hydroxyglutarate in tRNA GTP + + adenylosuccinate dUDP kinase: ndk UMP kinase: pyrH methionine arginine degradation L-threonine degradation IV L-threonine glycerol 3-phosphate CTP TorY protein Putative 3- peptidyl-prolyl D-ribose K KefB K synthetase: diphosphate dehydratase: fabA dependent 3-hydroxyacyl-CoA DNA with a blunt end crosslink 3-hydroxyacyl-CoA Putative 3- 2-oxoglutarate Putative beta- octanoul-ACP tRNA U34 periplasmic proteins glyoxalase NADH histidine synthetase: purA UDP-N-acetylglucosamine a (2E)-dec-2-enoyl-[acp] stearate synthase: lipoprotein posttranslational modification II (AST pathway) degradation II methionine- Protease degS pyranase: rhomboid carB carA 5 acyltransferase: dehydrogenase: hydroxyacyl-CoA hydroxyacyl-CoA reductase ((S)-2- cis-trans synthetase: III: elbB cupric BhsA phosphoribosylamine--glycine N -carboxyaminoimidazole dUTP reductase: UDP xanthine and xanthosine salvage 1-carboxyvinyltransferase: cellulose a long-chain cmoA dehydrogenase: Kdo2-lipid A (Z)-2- FMN dependent maltodextrin ketoacyl-ACP oxo-acid hydroxylase: diguanylate serine his ABC his a (2E)-hex-2-enoyl-[acp] lpxM lys short chain acyl-CoA exodeoxyribonuclease fadB dehydrogenase: dehydrogenase: hydroxyglutarate- isomerase: precursor: degS rbsD protease: reductase: ligase: purD ribonucleotide mutase: purE nrdF nrdE biosynthesis fatty acyl-CoA short chain fadB ile thr thr phosphoethanolamine CTP:2,3,4-saturated glucosidase: synthase: transaminase: aas trhO cyclase: dgcC endoprotease glyoxalase transporter dUTP UDP kinase: ndk murA trans-2-decenoyl- a [prolipoprotein]-L-cysteine lysine synthetase: fadK VII: xseA xseB exodeoxyribonuclease methylureidoacrylate Argininosuccinate NADH- [+ 2 isozymes] glpG β adenylo-succinate arg thr 3-hydroxyacyl-CoA c2467 c2467 forming): serA ppiB a 5- D-ribose III: yajL ndh GDP- -L- + + carbamoyl- asp CDP reductase: α acyl-CoA a 5- S-adenosyl-S- [+ 2 isozymes] threonine dehydratase: tdcB 7''-transferase: eptB V: recC recB recD L-phosphatidate peracid azoreductase: malZ c1186 ybdL [+ 5 isozymes] DegP: degP cleaved type-1 K KefC K diphosphatase: UDP-N-acetyl- - hexanoyl- (KDO) -lipid A ACP isomerase: fabA decarboxylase: ldcC threonine fatty acyl-CoA ssDNA-specific synthase: argG 34 + CAIR UDP kinase: adk cellulose 2 34 isoleucine dehydrogenase: [+ 3 isozymes] [+ 3 isozymes] 2-oxoglutarate a 3-oxotetradecanoyl- 2-oxo-4- [+ 4 isozymes] an octanoyl-[acp] hydroxyuridine pyranase: glycolate Cu galactose phosphate nrdB nrdA xanthosine synthetase: fadK hydroxyuridine carboxymethyl- threonine deaminase: ilvA cytidylyltransferase: amidohydrolase: rutB azoR (S)-3- a peptide c-di-GMP a peptide transmembrane GAR dut D-glucosamine- cellulose [acyl-carrier- phosphatidylglycerol--prolipoprotein lysine arginine N- dehydrogenase: synthetase: fadD exonuclease: recJ a long-chain (2E [acp] methylthiobutanoate a [protein]-L- in tRNA fucU Histidine adenylosuccinate UTP ADP-heptose:Kdo -lipid in tRNA L-homocystein 3-oxodecanoyl-CoA transaminase: (2Z)-2-aminobut-2-enoate threonine 7-O-[2-aminoethoxy(hydroxy) cdsA fadJ hydroxytetradecanoyl- a (1->4)- a (1->4)- proteins phosphoribosylaminoimidazole- [+ 2 isozymes] dCDP enolpyruvate protein] 2 a (3Z)-dec-3-enoyl-[acp] fatty acyl-CoA diacylglyceryl transferase: lgt decarboxylase: cadA succinyltransferase: tdh 3-oxo-(11Z)- maltohexaose )-2-enoyl-CoA α proline (ω = 0) ABC aspartate lyase: purB xanthosine synthase: A heptosyltransferase: ilvE aldolase: ltaE α a 1,2-diacyl-sn-glycerol a double stranded DNA peptidoglycan peptidoglycan α-D-glucan α -D-glucose β-D-ribofuranose his his succinocarboxamide reductase: fabI synthetase: fadD acetyl-CoA C- cadaverine phosphoryl]- -D-Kdo-(2->4) an oxidized CoA -D-glucan + + NfrA transport phosphoribosylglycinamide dCDP kinase: adk CTP synthetase: pyrG phosphorylase: xapA UDP-N- bcsB bcsA a [prolipoprotein]-S-1,2- astA L-threonine a 3-methyl-branched 2,3,4- a single-stranded with a RecA protein (Z)-2- canavaninosuccinate N,N-dimethyl-1,4- tetrapeptide, tripeptide, trimethylamine octadecenoyl-CoA K Kch K carbamoyltransferase: synthase: purC dUMP waaC tRNA U34 (S)-3-methyl-2- L-arginine degradation V -α-D-Kdo-(2->6)-lipid A AMP a ribonucleoside carbamate anthranilate formyltransferase 1: purN acetylenolpyruvoylglucosamine cellulose Putative 3- acyltransferase: 2 diphosphate a CDP-2,3,4-saturated- TorY protein system pyrB pyrI AMP dCDP kinase: ndk xanthosine stearoyl-CoA carboxymethyltransferase: diacyl-sn-glyceryl-L-cysteine oxopentanoate N -succinyl- (arginine deiminase pathway) dehydrogenase: saturated fatty acyl-CoA 5'-monophosphate oligodeoxyribonucleotide loaded 3' overhang methylaminoacrylate phenylenediamine glycan chain 2 glycan chain 1 thymidylate CTP reductase: murB a hexanoyl-[acp] heptosyl-Kdo -lipid A oxoacyl-[ACP] fadI cadaverine acetaldehyde gly diacylglycerol SAICAR phosphorylase: ppnP 2 cmoB L-arginine yiaY FGAR adenylate synthase: thyA dCTP xanthine ala UDP-N-α-D- synthase: c1189 aminotransferase: patA 2-oxo-3-methyl- 2-amino-3- D-allose prolipoprotein signal 3-ketoacyl-CoA 2-iminobutanoate + + β-ketoacyl- ADP-heptose--LPS isovalerate N-succinylarginine arg acetaldehyde oxobutanoate K Kup K D-allose ABC D-allose N-carbamoyl- 5'-phosphoribosyl-4-(N- kinase: adk acetylmuramate β-keto-cis-∆ 5 - thiolase: fadA α dTMP a 5-(carboxymethoxy) peptidase: lspA dehydrogenase: an (S-diacyl-sn- an alkylated an - RNase III mRNA 2552 a phosphorylated a (5Z)-3- D-myo-inositol phosphoribosylformylglycinamide L-aspartate adenine and xanthine glt ACP heptosyltransferase: 5-aminopentanal dehydrogenase: dihydrolase: astB an exoaminopeptidase melibionate (2R,3S)-3- uridine (R)-2- sn-glycerol 1-oleyl-2-lyso- D-gluconate a [protein]-L- 2'-UMP transporter succinocarboxamide)-5- dodecenoyl-[acp] 34 2-amino-3- a phosphatidylethanolamine glutathione 2-hydroxyethyldisulfide pentadecanoate H O decanoate hydroxylamine phytol glycolate ethylphosphate Ag43 uridine in tRNA adhE glyceryl)-L-cysteinyl- 2 adenine in DNA deoxyadenosine processing a peptide isocitrate L-kynurenine a protein PLP oxotetracos- (2,3,4,5) synthetase: purL ADP adenosine phosphoribosyltransferase: gpt UDP-N- synthase: fabF waaF octanoyl-CoA lpdA 2 Putative GTP substrate isopropylmalate in 23S rRNA hydroxyglutarate 3-phosphate phosphatidate methionine aminoimidazole lyase: purB dTMP kinase: tmk synthase: fabB 5 N -succinyl- ketobutyrate D-gluconate 5- dihydroorotase: glutamate tRNA cmo U34 an (S-diacyl-sn-glyceryl)-L- 5-aminopentanal arginine [apolipoprotein] in DNA substrate (2S)-2- 23S rRNA 2'-O 2-oxoglutarate acyl-CoA:sn dehydrogenase acyl-CoA:1-acyl- alcohol pyridoxal 5-enoyl-[acp] Peptide tetrakisphosphate Glycolate salvage V acetylmuramate--L- [+ 3 isozymes] (heptosyl) - phosphatidylglycerol biosynthesis I (plastidic) a lipoprotein signal peptide 2-methylbutanoyl- acetaldehyde isocitrate kynurenine- 3-oxoacyl- + + 2 cysteinyl-[apolipoprotein] L-ornithine L-cysteine CoA ligase: kbl isopropylmalate -ribose U2552 reductase ((R)-2- sn-glycerol-3- dehydrogenase: Protease degS dehydrogenase: methionine oxidase K TrkH K curli FGAM pyrC AICAR ADP reductase: alanine ligase: murC racemase: Kdo -lipid A methyltransferase: Putative acyl-coa dehydrogenase: patD deiminase: dehydrogenase: α -glycerol-3- dehydrogenase oxoglutarate phosphatase: [ACP] dTDP XMP 2 a (5Z)-3-oxododec-5-enoyl-[acp] CoA 2-oxobutanoate degradation II 2-hydroxyethyldisulfide short chain acyl-CoA short chain acyl-CoA DNA-3- -galactosidase: kduD precursor: degS secretion murI cmoM lipoprotein dehydrogenase: succinylornithine c5350 apolipoprotein N- hydroxylamine hydro-lyase (2- methyltransferase: hydroxyglutarate- phosphate 1-O- phosphate 2-O- adhE yigL sulfoxide subunit nrdB nrdA adenine peptidoglycan maturation (meso-diaminopimelate containing) a 3-oxooctanoyl-[acp] lipopolysaccharide apolipoprotein N- eutE gly reductase: yghU synthetase: fadK GTPase: synthetase: fadK metalloaminopeptidase: methyladenine endonuclease ribonuclease aminopeptidase: melA phosphatase: transaminase: reductase: phosphoribosylformylglycinamide (S)-dihydroorotate dTDP kinase: ndk DHAP signal peptide 5-aminopentanoate transaminase: astC reductase: hcp isopropylmaleate- rlmE forming): serA acyltransferase: [+ 2 isozymes] [+ 2 isozymes] [+ 2 isozymes] reductase glcD: glcD uridine CsgA and CsgA adenosine UDP-N- glucosyltransferase: 3-oxo-cis-∆ 5 - a 5-(methoxycarbonylmethoxy) acyltransferase: lnt c2464 Pyruvate formate-lyase acyltransferase: lnt hflX a 2'-O- acyltransferase: aceK aspC [+ 2 isozymes] fabG D-myo- AICAR transformylase: purH pyrimidine nucleobases salvage II 2 2-hydroxyethyldisulfide fatty acyl-CoA fatty acyl-CoA ypdE glycosylase I: tag IV: nfo III: rnc pepA a (3R,5Z)-3- dTDP kinase: adk undecaprenyldiphospho-N-acetyl- glycerol-3-phosphate 34 peptidase: rseP N -succinyl- cys acetyl-CoA forming): leuC leuD 2552 an isocitrate 4-(2-aminophenyl)- plsC 5-dehydro- msrA: msrA ethanol 2+ 2+ LpoB assembly cyclo-ligase: purM phosphorylase: acetylmuramoyl- D-glutamate 3-oxoacyl- waaG dodecenoyl-[acp] uridine in tRNA acyl-CoA 2 activating enzyme: pflC L-citrulline [+ 7 isozymes] methyluridine 2-oxoglutarate 1-C16:0-α,ωplsB- a peptide phytenal pyridoxal a protein-L- inositol (2,4,5) glyoxylate Mn MntP Mn an N-acyl-(S-diacyl-sn-glyceryl) reductase: yfcG synthetase: fadD synthetase: fadD (2S)-2- 2,4-dioxobutanoate 1-18:1-2-18:1- D-gluconate hydroxytetracos- complex dADP L-alanine (N-acetylglucosaminyl)muramoyl- [ACP] dehydrogenase: gpsA signal peptide dehydrogenase: 5-aminovalerate (E)-2- L-glutamate 5- L-cysteine glycine cleavage an N-acyl-(S-diacyl- in 23S rRNA dehydrogenase trisphosphate dTTP ppnP cytosine glucosyl-(heptosyl) reductase: fabG -L-cysteinyl-[lipoprotein] [+ 4 isozymes] α-D-galactose D-gluconate isopropylmalate dicaboxyl-2- phosphatidate 5-enoyl-[acp] methionine- AIR FAICAR L-alanyl-γ-D-glutamyl-meso-2,6- peptidase: sppA transaminase: gabT methylcrotonoyl- semialdehyde desulfhydrase: a 1-lysophosphatidylethanolamine an apurinic site a 5'-α- RNase III A ammonium H O reductase: sn-glycerol 3-phosphate fadE L-serine degradation sn-glyceryl)-L- a [DNA]-3'- a single- 2 a purine YbbY a purine adenosine -Kdo -lipid A GDP + 3-methyladenine lysophosphatidate S-oxide PRPP diaminopimeloyl-D-alanyl-D-alanine 2 2 a (3R,5Z)-3-hydroxydodec- ornithine a [glycine- H a proteinogenic within DNA a proteinogenic orotate cytosine deaminase: codA UDP-N- fabG CoA succinylglutamate propionyl-CoA malY cysteinyl-[lipoprotein] phosphate a peptide hydroxyl deoxyadenosine-5- processing stranded RNA a peptide phosphorylase: peptidoglycan lipopolysaccharide 5-enoyl-[acp] glutarate semialdehyde carbamoyltransferase: cleavage complex 2-mercaptoethanol GSSG AMP pentadecanoyl-CoA diphosphate AMP decanoyl-CoA diphosphate amino acid amino acid Ni 2+ CorA Ni 2+ dADP kinase: ndk acetylmuramoyl- acyl-acp:sn-glycerol- a peptide trans-oct-2-enoyl-CoA Putative semialdehyde [+ 4 isozymes] phosphate-[DNA] product mRNA IMP cyclohydrolase: purH deoD uracil glycosyltransferase: a (3R)-3- core heptose 2-aminoprop- H protein] N 6 -[(R L-alanine--D- 3-phosphate 1-O- crotonase: dehydrogenase: phosphate argI ser glycine orotate adenosine pbpC hydroxyoctanoyl-[acp] (I) kinase: waaP 3-hydroxydodecenoyl- enoyl-CoA glutarate-semialdehyde 2-enoate )-lipoyl]-L-lysine MliC predicted uracil glutamate acyltransferase: plsB c5023 astD propionyltransferase: pta decarboxylase: asp CAIR phosphoribosyltransferase: [acp] dehydrase: fabA dehydrogenase: sad serine transporter phosphoribosyltransferase: upp [+ 2 isozymes] glucosyl-(heptosyl) - periplasmic disulfide bond formation hydratase: fadJ 2-methyl-3- gcvP β 1 24-hydroxy-3- dATP ligase: murD (3R)- 2 2 carbamoyl- deaminase: Dihydrolipoamide a partially deacetylated poly- - an N - an apo-[c-type 3-hydroxybenzoyl- RNase E mRNA a PepB an [RNA]-3'- a non-methylated 34 a [lipoyl-carrier a 3,5,7,9,11,13,15- 2-deoxy-D- a (6Z)-3- a 3'-half-tRNA sorbose sorbose pyrE IMP adenosine a nascent peptidoglycan glutarate-semialdehyde N - maltoheptaose a cytidine 3-hydroxy-5-trans a ribonucleoside (2E,6E)-farnesyl phenoxy 2+ 4-nitrophenyl 2'CMP 2+ Ni(2+) ABC 2+ complex of Kdo -lipid A-phosphate a 2-lysophosphatidate [+ 2 isozymes] hydroxybutyryl- propanoyl phosphate L-ornithine 2-oxoglutarate arachidonate succinate a heme(III)-bound H O pimeloyl-CoA 6 oxocholest-4- an aldehyde Ins(1)P Fe Ni Ni UMP γ hydroxymyristoyl- 2 phosphate tdcG dehydrogenase: 1,6-N-acetyl-D-glucosamine I methyladenine a tRNA precursor cytochrome]-- CoA 2 ala processing aminopeptidase ribonucleoside- ribosomal protein]-N -[(R) hepta-oxo- glucose 6- oxooctadec- molecule with deaminase: with (L-alanyl- -D-glutamyl- a (2E,5Z)-dodeca-3,5-dienoyl-[acp] two reduced dehydrogenase: gabD CoA succinylglutamate ATP CcmE protein in tRNA -dodecenoyl-CoA 5'-monophosphate diphosphate radical VII phosphate transporter a sorbose phosphoribosylaminoimidazole- UDP-N- lipopolysaccharide core an [oxidized a [reduced an electron- in RNA CTP substrate 2',3'- protein L11 tRNA (cytidine- Putative 3- -dihydrolipoyl]- en-26-oyl-CoA hexadecanoyl-[PKS-acp] phosphate aldehyde a 5'-OH end non-heme meso-2,6-diaminopimeloyl-D- [acyl carrier acyl-[acp]:1-acyl-sn- cysteine residues superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass (S)-3-hydroxyoctanoyl-CoA carbamoyl [+ 3 isozymes] lpdA CcmH disulfide substrate ribosomal Putative 3- pyrimidine 5'- Putative 2-deoxyglucose- farnesyl inositol- 6-enoyl-[acp]3-oxoacyl- orotidine 5'- add acetylmuramoyl- DsbA protein] DsbB protein] transfer quinone propionate kinase: ackA 2-iminopropanoate 2-aminoprop- a [glycine- reductase: 2'-5' RNA succinocarboxamide protein] heptosyltransferase: 5 glutarate β cyclophosphate 2'-O)-ribose hydroxyacyl-CoA L-lysine diphosphate bacterial cystine YijE cystine phosphate superpathway of guanine and guanosine salvage meso- alanyl-D-alanine) pentapeptide cis-∆ -dodecenoyl- glycerol-3-phosphate 2- in a protein succinylglutamate phosphate 2-enoate a [glycine-cleavage endo-poly- -1,6- 3-hydroxybenzoyl- maltodextrin RNA 2',3'-cyclic protein L11 Dihydrolipoamide hydroxyacyl-CoA nucleotidase: aldo/keto 6-phosphate phosphate [ACP] synthase: purC L-alanyl-- waaQ propionate kinase: tdcD cleavage complex N1- short chain acyl-CoA Succinyl-CoA synthetase methyltransferase: dehydrogenase: yqhD ligase: ferritin: AcrZ diaminopimelate dehydratase: fabZ [acp]:NAD+ O-acyltransferase: plsC 3-hydroxyacyl-CoA desuccinylase: astE 6 D-glucosamine 8-amino-7- phosphorylase: methyltransferase: dehydrogenase: yjjG reductase: phosphatase: phosphatase: reductase: inosine D-glucopyranose 6-phosphate synthetase: 6 complex H protein] N - synthetase: fadK CCA tRNA alpha chain: c5037 holocytochrome CoA ribonuclease: aminopeptidase: phosphodiesterase: dehydrogenase: phosphatase: thpR predicted Orotidine 5- D-glutamate D-alanyl-D-alanine peptidoglycan DD- glucosyl-(heptosyl) - dehydrogenase: glutarate 2- H protein] N - methyladenine oxononanoate trmL c2467 bacA [+ 3 isozymes] 6-hydroxy-2- ftnA cytidine 3-hydroxydecanoyl- 3 oxidoreductase: fabI 2-methylacetoacetyl- hydrolase: pgaB malP prmA a 2'-O- 3,24- c2467 [+ 2 isozymes] c0413 suhB a (3R,6Z)-3-fabG ATP-driven propanoate carB carA dihydrolipoyl- aminomethyldihydrolipoyl- fatty acyl-CoA nucleotidyltransferase: cca Succinyl-CoA synthetase c synthase: ccmF thioesterase: entH rne pepB an [RNA]-3'-thpR a methylated 5-trans-3-oxo- a [lipoyl-carrierlpdA 9-hydroxy-3,5,7,11,13,15- hxpB (2E,6E)-farnesyl [FeO(OH) 4-nitrophenol phosphate carboxypeptidase: transpeptidase: mrdA Kdo -lipid A-phosphate a phosphatidate fadB hydroxylase: glaH CoA demethylase: synthase: bioF 34 2-deoxy- an alcohol myo-inositol (4-hydroxy- a ligated tRNA SAICAR guanosine [acyl-carrier- 2 glucose-6-phosphate L-lysine ribosomal methylcytidine 6 dioxocholest-4- a ribonucleoside hexaoxohexadecanoyl- hydroxyoctadec- ] monomer D-ribose transporter D-ribose superpathway of pyrimidine deoxyribonucleoside salvage UDP-N- succinate L-lysine alkB synthetase: fadD beta chain: c5036 ribunucleoside- dodecenoyl-CoA protein]-N -[(R D-glucose phosphate phenoxymethylene) decarboxylase: inosine dacD [+ 2 isozymes] a mature peptidoglycan with protein] lipopolysaccharide a (5Z)-dodec-5-enoyl-[acp] isomerase: pgi [+ 2 isozymes] glt carbamate pyruvate a partially deacetylated a partially deacetylated α protein L11 in tRNA en-26-oyl-CoA [PKS-acp] 6-enoyl-[acp] complex ZipA acetylmuramoyl- (S)-2-hydroxyglutarate 2-iminopropanoate -D-glucose 2'-phosphate )-lipoyl]-L-lysine 5'-phosphoribosyl-4-(N- pyrF kinase: gsk D-alanine [+ 5 isozymes] (L-alanyl-γ-D-glutamyl-meso- core heptose CTP:phosphatidate β β a tRNA a CcmE-[c-type RNase E a single- maltohexaose -benzofuran-3-one 2'-deoxycytidine dehydratase: fabA protein 3-oxooctanoyl-CoA poly- -1,6-N-acetyl-D- poly- -1,6-N-acetyl-D- 3-hydroxybenzoate 8-amino-7- a proteinogenic 1-phosphate of D-ribose succinocarboxamide) L-alanyl-D- a nascent peptidoglycan 2,6-diaminopimeloyl-D-alanyl- cytidyltransferase: cdsA F6P containing a cytochrome--CcmH coenzyme A processing a peptide UMP guanosine (II) kinase: waaY disulfide glutamate aminomethyltransferase: glucosamine (fragment 1) glucosamine (fragment 2) formaldehyde an adenine in RNA succinate AMP arachidonyl-CoA GDP succinyl-CoA oxononanoate stranded RNA amino acid Ag43 glutamate--2,6- a nascent peptidoglycan with D,D cross-links (meso- L-2-hydroxyglutarate diphosphate 3' CCA end phosphate disulfide] complex product mRNA Ribose -5-aminoimidazole D-alanine--D- D-alanine) pentapeptide a (2E)-oct-2-enoyl-[acp] glucosyl-(heptosyl) oxidase acetyl-CoA C- L-arginine degradation III dependent UMP biosynthesis II deoxycytidine IMP phosphorylase: diaminopimelate γ diaminopimelate containing) a CDP-diacylglycerol dehydrogenase: lhgD acetyl-CoA propionyl-CoA gcvT transport lyase: purB alanine with (L-alanyl- -D-glutamyl- -Kdo -lipid A- (quinone) 6-phosphofructokinase: acyltransferase: deaminase: cdd guanosine xapA ligase: murE 3 2 fructose-1,6- (arginine decarboxylase/ CO acid resistance meso-2,6-diaminopimeloyl- octanoyl- pfkA 2 D-ribose system D-ribose ligase: ddlA bisphosphate CDP-diacylglycerol--glycerol- : dsbB bisphosphatase: fbp fadI 2-oxoglutarate alanine agmatinase pathway) pyruvate AICAR dCMP kinase: gsk [+ 2 isozymes] 1 α YaiY guanine D-alanine) tetrapeptide [acyl-carrier- superpathway of (Kdo) -lipid A biosynthesis 6-phosphofructokinase: degradation I glt a 5,10- a 2-thiouridine 34 an N - an N-acetyl-β- a pyrimidine (11Z)-(S)-3- a cytidine 2498 a guanine 46 OPC4-3- a UDP-sugar an oxidized a 1,2-diacyl- a [protein]- d-biotin d UDP- -D- permease gln 2'-deoxyuridine UDP-N- D-alanine--D- 2 3-phosphate 3- [+ 2 isozymes] 3-ketoacyl-CoA a heme(III)-bound [DNA] octanoate H O ATP carbamoyl- a ribonucleoside maltopentaose an oligopeptide (E)-2-pentenol geranyl citrate syringaldazine a cis-delta11-3- D-ribofuranose pyridoxine bicarbonate 2-oxoglutarate methyladenine a CcmAB complex 2 D-hexosaminide ribonucleotide sn-glycerol 3- galactose protein rbsC dCMP phosphoribosyltransferase: gpt alanine a mature peptidoglycan protein] phosphatidyltransferase: pfkB arg glutamate methylenetetrahydrofolate in tRNA L-canaline formate triphosphate hydroxyhexadec- in 23S rRNA in tRNA hydroxyacyl-CoA hybrid- diphosphate L-arginine -sulfoxide 5'-phosphate AICAR acetylmuramoyl- L,D- L,D- L,D- thiolase: fadA CcmCDE complex phosphate AcnB: acnB oxo-C30:1-[acp] ribokinase: reductase: fabI D-ribulose in DNA 11-enoyl-CoA 23S rRNA 2'-O 7 Putative 3- cluster protein diphosphate aldehyde Putative biotin 2+ YddW transformylase: deoxyuridine kinase: guanine γ ligase: ddlB with D,D cross-links (meso- pgsA ala arginine decarboxylase 3-hydroxyacyl-CoA tRNA m G46 Protease degS diacylglycerol geranyl polyphenol 3-oxoacyl- Zn ABC guanine L-alanyl- -D- transpeptidase: ldtD carboxypeptidase: transpeptidase: ldtD galactosyl-glucosyl- fructose 1,6-bisphosphate NADH reductase: rbsK 2+ 2+ cmk phosphoribosyltransferase: hpt diaminopimelate containing) 5-phosphate DHAP hexanoyl-CoA glutamate β-N- pyrimidine- maltodextrin dehydrogenase: -ribose C2498 methyltransferase: hydroxyacyl-CoA precursor: degS diphosphate aconitate oxidase: arginine sulfoxide Zn Zn purH carbamoyl kinase: tdk glutamyl-meso-2,6- (heptosyl) -Kdo - alanine decarboxylase, B: gadB 5-aminomethyluridine- exodeoxyribonuclease short chain acyl-CoA RadD oxidoreductase: pyrophosphate [ACP] transporter L,D ldtD a mature peptidoglycan an octanoyl-[acp] 3 2 N1- ribonucleoside- methyltransferase: dehydrogenase: yahK hydratase Putative deiminase: reductase: phosphate D-alanyl-D-alanine D-arabinose a phosphatidylglycerophosphate glutamine degradation X racemase: alr degradative: adiA release of heme- acetylglucosaminidase: Ornithine 5'-nucleotide phosphorylase: fadB trmB [+ 2 isozymes] phosphatase: phosphatase: pgeF reductase: dCDP diaminopimelate a nascent peptidoglycan γ polymyxin resistance lipid A-bisphosphate Putative aldolase: c4284 asparagine glutamate tRNA synthase: I: sbcB synthetase: fadK ATPase: radD 7 hcr YohD FAICAR thymidine GMP transpeptidase: ldtE with (L-alanyl- -D-glutamyl- an intra- a [reduced an [oxidized an electron- Putative acyl-coa degradation I methyladenine bound CcmE: nagZ carbamoyltransferase nucleosidase: triphosphate malP rlmM an N - c2467 [+ 3 isozymes] nudI 1: acnA tetramethoxy ribokinase: c5350 bisC UDP-Galf synthetase: dUMP a nascent peptidoglycan with with (L-alanyl-γ-D-glutamyl- UDP-D- a (3R)-3- 5-phosphate triose-phosphate [+ 2 isozymes] arginine degradation I decarboxylase mnmE mnmG (11Z)-3- [+ 2 isozymes] a 2-O- pgpB a cis-delta11-3-fabG meso-2,6-diaminopimeloyl- β-ketoacyl- protein disulfide DsbA protein] DsbB protein] transfer quinol [+ 4 isozymes] dehydrogenase: demethylase: [+ 3 isozymes] fatty acyl-CoA ATPase: ychF reductase: nrdD methylguanine 46 OPC4-3- a reduced hybrid- a peptide geranyl azobismethylene c0331 a [protein]- pyridoxine carB carA dCDP γ UDP-α-D-glucuronate glucose:(glucosyl) hydroxytetradecanoyl- UDP-N-acetyl- isomerase: phosphatidylglycerophosphatase: isomerase: tpiA glt D-alanine ccmB ccmA chain I: c5348 ppnN oxohexadecenoyl- methylcytidine 2498 α a phosphatidate (E)-2-pentenal D-threo-isocitrate hydroxyC30:1- biotin Zn 2+ ABC D-alanyl- (L-alanyl- -D-glutamyl-meso- meso-2,6-diaminopimeloyl- decarboxylase, A: gadA synthetase: fadD ketoacyl-CoA an -D-aldose UMP L-citrulline 2+ 2+ IMP thymidylate thymidine a nascent peptidoglycan D-alanine) tetrapeptide ACP c2464 alkB in tRNA cluster protein monophosphate quinine D-ribofuranose Zn Zn kinase: adk D-alanine- LPS α-1,3- [acp] α-D-glucosamine gutQ pgpB gln Putative glutamate biosynthetic: speA 4-aminobutanoate an N-acetyl-β- α-D-glucose CoA in 23S rRNA 1-phosphate [acp] transporter cyclohydrolase: kinase: tdk with L,D cross links (meso- 2,6-diaminopimelate) tripeptide glycine) tetrapeptide UDP-glucuronate synthase: fabF asn a 5-(aminomethyl)-2- a 2'- maltotetraose 5-phosphate synthase: dCDP glucosyltransferase: [+ 2 isozymes] acyl-CoA glutaminase: dehydrogenase: D-alanine:quinone agmatine a 7,8-dihydrofolate + an alcohol D-hexosamine D-ribose 5- a 2'- carbamoyl- adding D-arabinose D-glyceraldehyde 3-phosphate 34 deoxyribonucleoside [DNA] ADP H a pyrimidine base 1-phosphate purH asp thyA diaminopimelate containing) dehydrogenase: arnA [+ 3 isozymes] dehydrogenase: L-asparaginase: thiouridine in tRNA a heme(III)-bound phosphate O-ureidohomoserine deoxyribonucleoside phosphate kinase: ndk adenine and adenosine salvage II enzyme: waaO acyl-[acyl-carrier- 5-phosphate glsB c0018 oxidoreductase an adenine in DNA formaldehyde succinate a CcmABCD complex AMP octanoyl-CoA phosphate β a phosphatidylglycerol CcmE protein 5'-monophosphate diphosphate adenine and adenosine salvage I UDP- -L-threo-pentapyranos-4-ulose protein]--UDP-N- fadE [+ 7 isozymes] 2-oxoglutarate (deaminating) agmatinase: ansA 5'-triphosphate 2+ 2+ YfhM dCTP murF a 3-oxodecanoyl-[acp] galactosyl-(glucosyl) isomerase: Glyceraldehyde Zn ZntB Zn IMP a mature peptidoglycan with a mature peptidoglycan -(heptosyl) -Kdo - acetylglucosamine O- 3-phosphate glt : dadA speB asp aspartate γ γ UDP-4-amino-4- 2 3 2 kdsD trans-hex-2-enoyl-CoA a mature peptidoglycan (L-alanyl- -D-glutamyl-meso- with (L-alanyl- -D-glutamyl- lipid A-bisphosphate acyltransferase: lpxA dehydrogenase A: c1843 Amine and Polyamine Degradation carbamoyltransferase: adenosine UDP-N-acetyl- deoxy-L-arabinose 3-oxoacyl- D-arabinose with L,D cross-links (meso- 2,6-diaminopimelate) tripeptide meso-2,6-diaminopimeloyl- pyruvate putrescine N-acetyl-D- UDP-N-acetyl- core oligosaccharide- ferric enterobactin 2251 1402 37 a negatively ∆ 2 ∆ 4 dTMP adenosine α-D-muramoyl- lipopolysaccharide glyceraldehyde- enoyl-CoA a 1-palmitoyl-2-acyl-sn guanosine a cytidine a guanine OPC8-3- 4-hydroxy- an isocitrate an organic trans- , cis- - trans-oct-2- a cis-delta17-3- L-methionine- cysteamine pyrB pyrI superpathway of 5-aminoimidazole aminotransferase: arnB [ACP] 5-phosphate α a primary alcohol linoleate paraoxon a 1-lysophosphatidylcholine a polypeptide PLP [DNA] histidinol selenate 2+ 2+ adenosine diaminopimelate containing) glycine) tetrapeptide glucosyltransferase: UDP-3-O-[(3R)-3- glucosamine -D-glucosamine lipid A (E. coli K-12 an oxidized azurin complex D-alanine in 23S rRNA in 16S rRNA in tRNA hydroxyacyl-CoA supercoiled DNA hydroperoxide D-cysteine decadienoyl-CoA enoyl-CoA D-serine Zn ZntA Zn inosine 5'- dTMP L-alanyl-γ-D- acyl-CoA hydrolysis 3-phosphate hydratase: fadJ allantoin degradation IV (anaerobic) -glycerol 3-phosphate dAMP L-threonine dehydrogenase oxo-C36:1-[acp] (S)-S-oxide S-phosphate ribonucleotide biosynthesis β reductase: superpathway of 4- 1 2,4-dienoyl- L-glutamine phosphorylase: ppnP UDP-4-amino-4-deoxy- -L-arabinopyranose waaJ hydroxymyristoyl]- allantoin degradation core type) (no GlcNAc) type I site-specific 23S rRNA 2'-O 16S rRNA 2'-O tRNA m G37 Putative 3- topoisomerase: histidinal/histidinol alkyl Putative methionine- selenate monophosphate superpathway of kinase: tmk glutamyl-meso-2,6- di-trans,octa-cis dehydrogenase: gapA [+ 2 isozymes] superpathway of N-acetylglucosamine, 5'-deoxynucleotidase: D-cysteine 3-oxoacyl- D-serine gln ABC gln fabG galactosyl-(glucosyl) N-acetyl-α-D- to glyoxylate III aminobutanoate degradation -ribose G2251 -ribose C1402 hydroxyacyl-CoA 4-hydroxythreonine isocitrate topA dehydrogenase: hydroperoxide CoA reductase: dehydrogenase: guanosine nucleotides N-carbamoyl- adenosine adenine diaminopimeloyl- -undecaprenyl UDP-4-amino-4- N-acetylmannosamine and N- ferric Putative alanyl deoxyribonuclease: methyltransferase: desulfhydrase, crotonase: [ACP] S-sulfoxide transporter dTDP PRPP -(heptosyl) -Kdo - glucosamine a 2,3,4-saturated fatty acyl CoA (S)-(+)-allantoin N-acetylglucosaminyltransferase: short chain acyl-CoA yfdR D-alanine methyltransferase: methyltransferase: dehydrogenase: dehydrogenase topoisomerase: reductase: reductase: deaminase: ynfG ynfE guaB de novo biosynthesis I L-aspartate phosphorylase: deoD deoxy-L-arabinose a (3R)-3- 3 3 2 D-arabinofuranose 13-DPG (S)-3-hydroxyhexanoyl-CoA acetylneuraminate degradation Putative alcohol hsdM c5425 c5423 trmD kinase: thrB hisD PLP-dependent: c5023 reductase: reductase: D-alanyl-D-alanine phosphate 4-aminobutanoate pgaC pgaD enterobactin synthetase: fadK phosphotriesterase- aminopeptidase: 1 kinase: aceK dsdA a heme ChuS a heme hydroxydecanoyl-[acp] lipid A-bisphosphate UDP-3-O-acyl-N- (S)-(+)-allantoin dehydrogenase: dAMP transaminase: a double stranded rlmB rsmI an N - c2467 topB ahpC ahpF fadH (S)-3- ynfF ynfH dTDP amidophosphoribosyltransferase: purF adenine formyltransferase: arnA 5-phosphate 2-O- a 2'-O- 4-phospho- a phosphorylated dcyD 2 fabG bisC dihydroorotase: allantoinase: N-acetylneuraminate 4-aminobutyrate esterase: fes fatty acyl-CoA related protein: c2495 pepN phosphohydrolase: 37 OPC8-3- trans-∆ - a cis-delta17-3- adenine acetylglucosamine 3-hydroxyacyl-CoA Aldehyde Degradation allantoinase: c0762 glyA DNA with 5'- 2251 1402 methylguanine hydroxy-L- a relaxed DNA his an alcohol hydroxyoctanoyl- pyruvate selenite cysteamine IMP kinase: ndk 5-phospho-β- Phospho-N- (3R)- 3-deoxy- acyl-CoA thioesterase: yciA phosphoglycerate N-acetylneuraminate methylguanosine methylcytidine isocitrate pyruvate hydroxyC36:1- met YdfJ pyrC phosphoribosyltransferase: apt UDP-4-deoxy-4-formamido- deacetylase: lpxC dehydrogenase: allB transaminase: β synthetase: fadD yfbR terminal phosphate in tRNA ketoacyl-CoA decenoyl-CoA CoA kinase: pgk allB poly- -1,6- UDP 3+ in 23S rRNA in 16S rRNA threonine dehydrogenase XMP dTDP D-ribosylamine acetylmuramoyl- β hydroxymyristoyl- UDP-3-O-(3- D-manno- acyl-CoA thioesterase: tesB lyase: nanA gabT Fe -[N-(2,3- N-(2,3- L-1-glycero-3- [acp] adenine -L-arabinopyranose fadB allantoate succinate N-acetyl-D- a hepta-acylated core a carboxylate 2'-deoxyadenosine (S)-dihydroorotate kinase: adk pentapeptide- [acyl carrier core oligosaccharide- hydroxymyristoyl) octulosonate superpathway of methylglyoxal degradation allantoate N-acetylneuraminate dihydroxybenzoyl) dihydroxybenzoyl) diethylphosphate 4-nitrophenol phosphocholine a polypeptide pyridoxamine inosine 5'- phosphoribosylamine--glycine phosphoribosyltransferase: apt AMP undecaprenyl-phosphate 3-phospho-D-glycerate [+ 2 isozymes] L-lactaldehyde semialdehyde glucosamine a 1-lysophosphatidate oligosaccharide lipid an aldehyde an L-amino acid pyruvate RseC xanthosine-5'- transferase: mraY protein] lipid A (E. coli K-12 α 8-phosphate a reduced azurin -L-serine] complex -L-serine AMP linoleoyl-CoA 5'-phosphate monophosphate dTTP ligase: purD 4-deoxy-4-formamido-L- - -D-glucosamine coenzyme A a 2,3,4-saturated fatty acid degradation allantoate N-acetyl-D-lyase subunit: c3639 allantoate A (E. coli K-12 type) diphosphate phosphate:L- AMP dehydratase: fabZ core type) (no GlcNAc) UDP-3-O-(3- synthase: kdsA 3-oxohexanoyl-CoA succinate succinate dehydrogenase: arabinose transferase: arnC Probable methylglyoxal L-lactaldehyde (anaerobic) amidohydrolase: mannosamine amidohydrolase: glutamine GAR undecaprenyldiphospho- hydroxymyristoyl) semialdehyde semialdehyde guaB 3-hydroxydecanoyl- phosphoglycerate phosphoglycerate allC allC NrfE amido- PRPP N-acetylmuramoyl-L- 4-deoxy-4-formamido-α-L-arabinopyranosyl glucosamine N- KDO-8P acetyl-CoA C- lactaldehyde L-lactaldehyde N-acetylmannosamine ethanolamine utilization dehydrogenase dehydrogenase orotate [acyl-carrier- mutase 2: gpmB mutase: gpmA 37 alanyl-γ-D-glutamyl-meso ditrans,octacis-undecaprenyl phosphate acyltransferase: methylglyoxal glyoxalase L-1,2-propanediol kinase: nanK (NAD + ): sad (NADP + ): gabD core oligosaccharide-lipid A (E. a 1-palmitoyl-2-acyl- an adenine a DNA containing an a [DNA]-nucleotide-3'- (2E,6E)-farnesyl 2-dehydro-3- UTP a guanine 527 an insertion sequence OPC6-3- D-glucose 1- an adenosine 34 a protein GDP-4-dehydro- a phosphate ligase (AMP- XMP phosphoribosylglycinamide protein] acyltransferase: dehydrogenase: S-ureidoglycine S-ureidoglycine an oxidized a primary alcohol 2-oxoglutarate 1-methyl-dATP O-succinyl-L- a tripeptide an acyl-[acyl- a nucleoside 3',5'- an oligopeptide a nucleoside a cis-delta21-3- hydrogenobyrinate -2,6-diaminopimeloyl- lipid A-core 2,3-bisphosphoglycerate- fadI reductase: yeaE I: gloA oxidoreductase: coli K-12 core type) (no GlcNAc) phosphatidylethanolamine in tRNA apurinic/apyrimidinic site phosphoglycolaldehyde protoheme IX deoxy-D-gluconate thr in 16S rRNA element IS30 hydroxyacyl-CoA cys phosphate mutated tRNA in [tRNA Arg2 ] with incorrect α-D-rhamnose YbgC forming): guaA adenine and adenosine salvage III formyltransferase 1: purN undecaprenyl lpxD 3-deoxy- aldA N-acetyl-D- cytochrome c550 homoserine diphosphate UTP carrier protein] bisphosphate diphosphate oxo-C40:1-[acp] monoester orotate dehydratase: fabA ethanolamine 7 Putative 3- tRNA pyrimidine D-alanyl-D-alanine independent [+ 4 isozymes] fucO mannosamine (S)-ureidoglycine succinate 16S rRNA m G527 Transposase: 3',5'-nucleoside sugar 3-oxoacyl- disulfide bondsPutative CobB phosphate-α-L-ara4FN UDP-2,3-bis[O-(3R)- 3-ketoacyl-CoA (S)-ureidoglycine pyrophosphatase: yhdE threonine phosphate cysteine oligopeptidase: RNase BN 34 nucleoside xanthosine-5'- phosphoribosyltransferase: ribonucleosides salvage I D-manno- phosphoglycerate (S)-lactate (S)-propane- hydroxyacyl-CoA phosphatase: adenosine FGAR thiolase: fadA S-lactoyl- aminohydrolase: 6-phosphate ethanolamine aminohydrolase: tRNA m 2 A37 1-methyl-dATP 2-dehydro-3- tripeptide dehydrogenase: tdh methyltransferase: c0072 bisphosphate diphosphate [ACP] disulfide protein: GMP asp phosphate:L- pyrE N-acetylglucosaminyl deformylase: arnD a (2E)-dec-2-enoyl-[acp] 3-hydroxymyristoyl]- octulosonate 1,2-diol apurinic/apyrimidinic heme O nucleoside triphosphate acyltransferase: transaminase: prlC ribonuclease: α mutase: gpmM glutathione N-acetylmannosamine- allE Putative alcohol 3'-phosphodiesterase: rsmG [+ 20 isozymes] dehydrogenase: phosphatase: hxpA deaminase: reductase: isomerase: cobB TufB cytidine transferase: murG -D-glucosamine 8-phosphate allE ammonia- methyltransferase: endonuclease: xthA demethylase: O-succinylhomoserine deoxygluconate aminopeptidase: pyrophosphohydrolase: L-threonine 7 plsX aspC rbn kinase: ndk glutamine adenine 4-amino-4-deoxy-α-L-arabinopyranosyl butanoyl-CoA acetol dehydrogenase: nfo synthase: an N - an insertion c2467 yciV [+ 3 isozymes] tadA GDP-3-dehydro- phosphoribosylformylglycinamide UDP-2,3- 6-phosphate lyase: eutB eutC rlmN alkB aldolase: yagE pepT 34 a cis-delta21-3-fabG a proteinc3787 hydrogenobyrinate adenylosuccinate amido- adenosine undecaprenyldiphospho- (KDO) -lipid A phosphatase: 2-phospho-D-glycerate S-ureidoglycolate endonuclease IV: nfo lyase: metB cyoE mazG dehydrogenase: yiaY 527 OPC6-3- a nucleoside 5'- a nucleoside 5'- an inosine a nucleoside 6-deoxy-α- an alcohol orotidine 5'- ditrans,octacis-undecaprenyl phosphate 2 S-ureidoglycolate c0762 methylguanine sequence IS30 with 3-mercaptopyruvate a peptide guanylate synthetase: purL superpathway of unsaturated diacylglucosamine L-1,2-propanediol hydroxyacylglutathione epimerase: nanE aminoacetone an acyl phosphate D-glucopyranose Arg2 hydroxyC40:1- with correct a,c-diamide synthetase: purA ligase (AMP- phosphorylase: ppnP cytidine cytidine N-acetyl-(N- decanoyl- trans-2- yrbI Putative acyl-coa UMP in 16S rRNA integrated transposon ketoacyl-CoA monophosphate monophosphate in [tRNA ] triphosphate D-mannose YeaQ kinase: gmk phosphate fatty acids biosynthesis (E. coli) diphosphatase: lpxH dehydrogenase: hydrolase: gloB N-acetyl-D- acetaldehyde a hepta-acylated core [acp] disulfide bonds forming): guaA kinase: udk deaminase: acetylglucosaminyl) [acyl-carrier- decenoyl-ACP dehydrogenase: ureidoglycolate a 1-lysophosphatidylethanolamine a 2- a [DNA]-3'- glycolaldehyde adenosine FGAM lipid IV 4-amino-4-deoxy-L- KDO enolase: eno [+ 2 isozymes] ureidoglycolate glucosamine oligosaccharide lipid a 5'-deoxyribose- D-glyceraldehyde a proteinogenic adenylo-succinate Orotidine 5- cdd A protein] isomerase: gldA L-lactaldehyde Ureidoglycolate lyase: allA 5'-deoxyadenosine met methyladenine 37 a [DNA]-3'-hydroxyl formaldehyde succinate 2-oxobutanoate hydroxyl phosphate pyruvate a dipeptide GDP phosphorylase: deoD muramoyl-L-alanyl- arabinosyltransferase: arnT lipid X c2464 (S)-lactate dehydrogenase: 6-phosphate A (E. coli K-12 type) an aldehyde a reduced dATP succinate ferroheme o amino acid CMP reductase: fabI fabA a (3R)-3-hydroxydecanoyl-[acp] degradation (aerobic) ethanol carnitine degradation I 5-phosphate-[DNA] YedA GMP phosphate adenosine phosphoribosylformylglycinamide γ-D-glutamyl-meso- 3-deoxy-manno- acyl-CoA (S)-propane- allD dehydrogenase: N-acetylglucosamine- acetaldehyde in tRNA cytochrome c550 adenylosuccinate decarboxylase: uridine α α α phosphoenolpyruvate 1,2-diol c3753 dehydrogenase: dehydrogenase: glyoxylate cyclo-ligase: purM 2,6-diaminopimeloyl- 4'- -L-Ara4N- -Kdo-(2->4)- - lipid A octulosonate dehydrogenase: (R)-lactate Ureidoglycolate 6-phosphate lyase: purB (3R)- L-lactaldehyde adhE pyrF uridine D-alanyl-D-alanine Kdo-(2->6)-[P4'-α-L-ara4N]-lipid A a decanoyl-[acyl- disaccharide cytidylyltransferase: fadE L-lactate deacetylase: nagA adhE L-carnitine guanylate adenosine a (3Z)-dec-3-enoyl-[acp] hydroxymyristoyl- phosphoenolpyruvate pyruvate kinase: pykA lactaldehyde dehydrogenase: YadS AIR kinase: udk carrier protein] synthase: lpxB c3689 dehydrogenase: D-glucosamine acetaldehyde [+ 2 isozymes] a DNA-3'- a guanine 1207 (S)-3- a guanine 966 L-glyceraldehyde RNase II D-glucosamine an (S)-2- a (9Z)-3- 5-nitro AMP UMP deaminase: add adenine and adenosine salvage IV D-lactate dehydrogenase: c3753 lipid A-core an N-terminal an L-phenylalanyl- an oxidized a primary alcohol an oxidized c- (R)-lactate glutathione bromoacetate a β-D glucoside an aryl dialkyl 7 thiamin 5-oxo-L-proline tellurite a cis-delta15-3- a nucleoside 5'- GDP kinase: gmk [acyl carrier protein] synthetase: ppsA Pyruvate kinase I: pykF crotonyl-CoA lldD dehydrogenase: carnitine--CoA a phosphatidylethanolamine methyl parathion glutathionylspermidine deoxyribose- hydroxyoctanoyl- m GTP degradation L-allo-threonine enterobactin oxooctacos- phosphocholine lipid A 6-phosphate arginyl-[protein] Phe in 16S rRNA in 16S rRNA 3-phosphate 6-phosphate hydroxycarboxylate benzisoxazole reductase: GDP UMP β-ketoacyl- Putative 3- dehydratase: fabZ 3-deoxy-manno dehydrogenase aldA [tRNA ] cytochrome c type cytochrome phosphate diphosphate oxo-C34:1-[acp] monophosphate eutE ligase: caiC L 5-phosphate 2 CoA 2 7 substrate mRNA sugar Glycolate tellurite 9-enoyl-[acp] HflC adenylate disaccharide -octulosonate (S)-lactate oxalurate ethanol 16S rRNA m G1207 3-hydroxyacyl-CoA 16S rRNA m G966 m GTP L-glyceraldehyde 5-oxoprolinase: 3-oxoacyl- 3-oxoacyl- Kemp nrdB nrdA kinase: ndk GDP ACP oxoacyl-[ACP] 3-hydroxydecanoyl- pyruvate enoyl-CoA (quionone): dld thiamin 3-hydroxy acid enterochelin reductase: inosine methyltransferase: methyltransferase: pyrophosphatase: 3-phosphate exoribonuclease pxpB phosphatase: oxidase [ACP] [ACP] eliminase: kinase: adk adenine synthase: fabF synthase: [acyl-carrier-protein] cytidylyltransferase: hydratase: fadJ phosphoethanolamine Putative bromoacetate dehydrogenase: pyrophosphate dehydrogenase esterase: fes GDP pyruvate L-lactate phenylalanyl- Putative alcohol Putative lactate glutathionylspermidine Putative rsmC rsmD yceF reductase: gpr II: rnb pxpC pxpA hxpA subunit narZ narY narV pdxI [+ 3 isozymes] c1189 kdsB [+ 2 isozymes] acetyl-CoA transferase: eptC phosphotriesterase- dehalogenase: 3'-phosphodiesterase: fadB hydrolase: nudJ reductase: reductase: kinase: adk GDP dehydratase: fabA dehydrogenase: α-D-glucosamine tRNA--protein amidase: gss phosphotriesterase- an N 2 - an N 2 - N 7 - YdfG: ydfG N-(2,3- glcD: glcD [+ 2 isozymes] Rbn ADP GDP pyrimidine inosine dehydrogenase dehydrogenase: dehydrogenase: sn-glycerol [+ 3 isozymes] fabG fabG 2-cyano-4- β ∆ 5 related protein: c2495 gstB nfo 1207 [+ 2 isozymes] 966 a 2-oxo a cis-delta15-3- a cis-delta9-3- kinase: ndk reductase: phosphorylase: xapA -keto-cis- lipid IV CMP-KDO lldD 6-phosphate L-carnitinyl-CoA transferase: aat related protein: c2495 methylguanine 3-oxooctanoyl- methylguanine methylguanosine thiamin phosphate a nucleoside 5'- aminoacetone glt dihydroxybenzoyl) 0 a nucleoside choline ribonucleosides a 3-oxododecanoyl-[acp] A multienzyme (S)-3-hydroxybutanoyl-CoA phosphate c0762 c5039 3-phosphate D-glucosamine Te hydroxyC34:1- hydroxyC28:1- nitrophenol ADP adenine adenine deaminase: adeD -dodecenoyl- a (2E)-dec-2-enoyl-[acp] glucosamine- Carnitinyl-CoA in 16S rRNA in 16S rRNA 5'-phosphate monophosphate -L-serine carboxylate GDP nrdB nrdA [+ 2 isozymes] complex: aceE carbamoyl- oxamate acetyltransferase: pta 4-aminobutyrate lipid A-core- a 1,2-diacyl- a non CoA GhoT salvage III phosphoribosyltransferase: apt CMP [acp] pyruvate pyruvate γ-butyrobetainyl- dehydratase: β-D-glucose [acp] [acp] dGDP reductase: kinase: adk 3-hydroxyacyl-CoA phosphate 6-phosphate phosphoethanolamine L-phenylalanyl-L- S-(acet-2-yl) glutathione spermidine 2-deoxy-D-ribose glucosylated D- a dialkyl cytidine phosphorylation 3-oxoacyl- 3-deoxy- phosphate degradation III caiD sn-glycerol Phe dimethylthiophosphate 4-nitrophenol bromide a [DNA]-3'- nrdB nrdA synthase: fabB trans-2-decenoyl- acetyl-CoA dehydrogenase: deaminase: CoA:carnitine a tRNA an aldehyde a reduced a reduced c- pyruvate -glutathione glucose acceptor a phenol cytidine hypoxanthine [ACP] D-manno- carbamoyl acetyltransferase: (hep I) arginyl-[protein] hydroxyl 5-phosphate phosphate CMP ACP isomerase: fabA fadB nagB CoA cytochrome c type cytochrome dGDP AMP hypoxanthine a (5Z)-3-oxododec- oxaloacetate eutD 4-aminobutanoate L RodZ GTP nucleosidase: rihA CMP reductase: octulosonic phosphate transferase: dGDP dADP GTP hypoxanthine 5-enoyl-[acp] [+ 2 isozymes] 4-aminobutyrate cytidine kinase: cmk fabG acid synthetase: F6P caiB kinase: adk dGDP phosphoribosyltransferase: gpt a (3Z)-dec-3-enoyl-[acp] citrate synthase: gltA transaminase: γ-butyrobetainyl- crotonobetainyl- nucleosidase: rihB hypoxanthine CDP 3-oxo-cis-∆ 5 - transferase: carB carA acetyl phosphate YhjD a (3R)-3- acetoacetyl-CoA core oligosaccharide-lipid A (E. a DNA containing UDP-N-acetylmuramoyl-L- an intrastrand non- 2-O-(α-D- 2445 (S)-3- 745 dGDP kinase: adk Hypoxanthine gabT CoA CoA a 1-palmitoyl-2-acyl- a [protein]- + a deoxyinosine uridine a single- a guanine a guanine a cytidine (2E,5Z)- a single cytosine phosphoribosyltransferase: gpt dodecenoyl- waaA γ amino-parathion NADPH NAD 5-hydroxytryptophol a primary alcohol hydroxypyruvate a sugar phosphate (E)-2-hexenol DNA with lesion n-butanol a cis-delta19-3- isoguanine benzaldehyde dADP CDP hydroxydodecanoyl-[acp] Putative 3- succinate coli K-12 core type) (no GlcNAc) S methyl alanyl-D- -glutamyl-meso-2,6- adjacent cyclobutane ν glucopyranosyl) stranded RNA hydroxyhexadecanoyl- 32 dodecenoyl-CoA Ap4A met kinase: ndk dGDP phosphoribosyltransferase: hpt Hypoxanthine malate acetyl-CoA carbamate acetate phosphatidylglycerol L-cysteine p h in DNA in 23S rRNA in 23S rRNA in tRNA oxo-C38:1-[acp] stranded DNA cytosine [acp] semialdehyde phosphotriester diaminopimeloyl-D-alanine thymidine dimer in DNA -D-glycerate 2 CoA 1 Putative alcohol hydroxypyruvate enoyl-CoA aldehyde Nucleotide aldehyde kinase: ndk kinase: adk (3R)- oxoacyl-[ACP] α acetyl-CoA malate:quinone 23S rRNA m G2445 Putative 3- 23S rRNA m G745 tRNA Cm32 Putative alcohol phosphosugar diadenosine 3-oxoacyl- methionine isoguanine DNA kinase: ndk phosphoribosyltransferase: hpt reductase: -Kdo-(2->6) dehydrogenase: mdh acetyltransferase: kinase: ackA uridine dehydrogenase: hydratase: reductase: reductase: MarC deaminase: codA synthase: c1189 oxidoreductase: mqo methyltransferase: hydroxyacyl-CoA methyltransferase: methyltransferase: dehydrogenase: reductase: ghrA phosphatase: excision [ACP] sulfoxide deaminase: primase: IMP CDP hydroxymyristoyl- fabG -lipid IV [+ 4 isozymes] atoB crotonobetainyl- Putative pyridine nucleotide nucleosidase: rihA polynucleotide tetraphosphatase: 5 A methylphosphotriester- L,D- deoxyribonuclease c0762 hydroxypyruvate yigL fadJ yahK repair: uvrA yahK dGTP dATP dGTP uracil IMP kinase: ndk [acyl carrier β-keto-cis-∆ - acetate CoA deoxyribodipyrimidine phosphotriesterase- transhydrogenase: glucosylglycerate phosphorylase: rlmL dehydrogenase: rlmA trmJ c0762 apaH reductase: reductase: codA dnaG a (3R,5Z)-3- KDO (S)-malate citrate DNA-protein-cysteine S V: nfi uridine an N 2 - an N 1 - a 2'-O- [+ 2 isozymes] [+ 2 isozymes] uvrB uvrC [+ 3 isozymes] LetB protein] dodecenoyl-[acp] malate synthase G: glcB acetyl-CoA reductase: caiA carboxypeptidase: c2467 5-hydroxyindole reductase: ghrB [+ 3 isozymes] [+ 3 isozymes] fabG msrB a short RNA transferase: photolyase: phr related protein: c2495 sthA phosphorylase: ycjM pnp 2445 745 32 a cis-delta19-3- xanthine salicylaldehyde CTP hydroxydodec- CO succinate methyltransferase: ada ldcA nucleosidase: rihB methylguanine 3-oxo- methylguanine methylcytidine an aldehyde D-glycerate (S)-3-hydroxy-(5Z) ADP (E)-2-hexenal DNA without butanal L-methionine- dehydratase: fabZ synthase: fabB malate synthase A: aceB 2 acetaldehyde a sugar hydroxyC38:1- segment 5-enoyl-[acp] waaA in 23S rRNA palmitoyl-CoA in 23S rRNA in tRNA -dodecenoyl-CoA lesion (R)-S-oxide a hepta-acylated core [acp] 3-hydroxydecanoyl- 3-hydroxydodecenoyl- α-Kdo-(2-> citrate hydro-lyase (cis- Carboxylate Degradation a 1-lysophosphatidylglycerol a DNA without a 5'-phospho- a deoxyinosine- a single- a (5Z)-3-oxododec-5-enoyl-[acp] oligosaccharide lipid a [protein]-S- UDP-N-acetylmuramoyl- a DNA with + α-D-glucose uracil a nucleoside RsxC [acyl-carrier- 4)-α-Kdo-(2- aconitate-forming): acnA S methyl 4-aminophenol diethylthiophosphate NADH NADP [DNA] [DNA]-3'-hydroxyl D-glycerate D-ribofuranose [acp] dehydrase: fabA A (E. coli K-12 type) p methyl-L-cysteine γ nonadjacent thymidines 1-phosphate diphosphate stranded RNA protein] D-alanine L-alanyl- -D-glutamyl- Aromatic Compound Biosynthesis 5 >6)-lipid IV fumarase A: fumA citrate hydro-lyase: acnB phosphotriester FetA 3-oxo-cis-∆ - A L-ascorbate meso-2,6-diaminopimelate Carbohydrate Biosynthesis dehydratase: fabA a (2E,5Z)-dodeca- L-ascorbate 2-methylcitrate cycle I citrate degradation pyruvate decarboxylation to acetyl CoA dodecenoyl-[acp] [+ 4 isozymes] degradation II 2-methylcitrate cycle II 3,5-dienoyl-[acp] degradation I enterobactin biosynthesis a (2E)-dodec- reductase: fabG palmitoleoyl fumarate cis-aconitate (bacterial, aerobic) an acetyl-holo Alcohol Degradation 5 a [pyruvate dehydrogenase a 2,3,4- gluconeogenesis I 2-enoyl-[acp] cis-∆ -dodecenoyl- lauroyl (bacterial, anaerobic) propanoate core oligosaccharide-lipid A (E. a 1-palmitoyl-2-acyl- an N-terminal a ring-opened 7- an aminated amino hydrogen a [DNA]-nucleotide- a 7,8-dihydro-8- a guanine 1835 adenine 1618 a uracil 1498 3-hydroxyadipyl- β-L-galactose D-mannitol β PRPP biosynthesis propanoate 6 an L-phenylalanyl- UDP-N-acetyl-D- ADP-L-glycero- -D-manno GDP-mannose biosynthesis glycogen biosynthesis I (from ADP-D-Glucose) a (3R,5Z)-3-hydroxydodec- acyltransferase: D-threo-isocitrate L-ascorbate L-ascorbate citrate [citrate lyase acyl- E2 protein] N -lipoyl-L-lysine vanillin glycerophosphoserine A(H2) maltose 4-guanidinobutyramide shikimate riboflavin n-propanol thiosulfate n-butanol saturated (3R)-3- a cis-delta13-3- a signal peptide GSSG ATP dodecyl sulfate YhjX [acp]:NAD+ acyltransferase: glyoxylate coli K-12 core type) (no GlcNAc) phosphatidylserine L-lysyl-[protein] Phe methylguanine in DNA group donor peroxide 3'-phosphoglycolate oxoguanine in DNA in 23S rRNA in 23S rRNA in 16S rRNA CoA 1-phosphate 1-phosphate glucosamine biosynthesis I -heptose biosynthesis chorismate dodecanoyl- 5-enoyl-[acp] lpxP hydro-lyase (cis- carrier protein] pyruvate superpathway of glycol [tRNA ] dITP oxo-C32:1-[acp] oxidoreductase: lpxL 6-phosphate propionyl- ethanol degradation I glycerol degradation V 2 6 3 Putative Putative 3- flavin sugar Putative propanol alcohol mannitol-1- hydroxyacyl-CoA signal (S)-malate D-glucopyranose D-ribose 5- L-ascorbate- propionyl- Pyruvate metabolism and degradation ethanol degradation II 23S rRNA m G1835 23S rRNA m A1618 16S rRNA m U1498 shikimate thiosulfate Putative 3-oxoacyl- glutathione adenylate UspB D-glucopyranose [acyl-carrier- aconitate-forming): acnA CoA deoxyinosine triphosphate amidase: ybeM hydroxyacyl-CoA reductase: cysJ phosphatase: dehydrogenase: dehydrogenase: phosphatase: peptide D-glucopyranose D-sedoheptulose phosphate isochorismate fabI 3-hydroxydodecenoyl- 6-phosphate CoA dehydrogenase Pyruvate Putative DNA- methyltransferase: methyltransferase: methyltransferase: dehydrogenase: sulfurtransferase: [ACP] reductase: cyclase: 6-phosphate 6-phosphate protein] D-threo-isocitrate L-dehydro- synthetase: Citrate phenylalanyl- Formamidopyrimidine- glycerophosphoserine hydroperoxidase: 3'-phosphodiesterase: amylomaltase: pyrophosphatase: rdgB c4524 adhE crotonase: peptidase: 6-phosphate 7-phosphate glucose-6- ribose-phosphate synthase: menF [acp] dehydrase: fabA KDO - lactonase: synthetase: E1 component: dehydrogenase ethanol glycerol rlmG rlmF rsmE Putative ydiB dehydrogenase: riboflavin hxpA glpE hxpB reductase: gor cyaA glucose-6- reductase: fabI a (5Z)-dodec- 2 ascorbate lyase ethylene glycol ethanol aminotransferase: formamidopyrimidine malQ 2 6 3 c5023 Phosphoheptose phosphate phosphoglucomutase: diphosphokinase: prs hydro-lyase: acnB prpE tRNA--protein DNA glycosylase: mutM phosphodiesterase: ugpQ katG xthA nucleoside triphosphate an N - an N - an N - amidase: c2457 c2467 reductase: fre [+ 3 isozymes] [+ 2 isozymes] rseP phosphate isochorismate (KDO) -(lauroyl) (palmitoleoyl) ulaG prpE aceE E1 component: ethanol glycerol c1175 glycosylase: mutM [+ 3 isozymes] [+ 4 isozymes] a cis-delta13-3-fabG Putative PTS isomerase: gmhA 5-enoyl-[acp] 2 isocitrate lyase: aceA alpha ethanol transferase: aat pyrophosphohydrolase: 1835 1618 1498 3-dehydroshikimate sulfite glutathione cyclic-AMP 1-dodecanol D-glycero-D- isomerase: pgi pgm PRPP -lipid IV 3-keto-L-gulonate [+ 3 isozymes] aceE glycolaldehyde dehydrogenase: methylguanine methyladenine methyluracil 4-guanidinobutyrate 3-oxoadipyl-CoA reduced riboflavin L-galactopyranose propanal butanal D-mannitol a cis-2-enoyl-CoA isomerase: pgi synthase: entC a dodecanoyl-[acp] a (2E,5Z)-dodeca-3,5-dienoyl-[acp] A -lipid IV succinate D-threo-isocitrate [+ 3 isozymes] chain: citF Dihydrolipoamide dehydrogenase: adhE hydroxyC32:1- a peptide system IIC F6P A dehydrogenase: mazG in 23S rRNA in 23S rRNA in 16S rRNA manno-heptose α-D-glucose Putative beta- myristoyl-acyl 6-phosphate dehydrogenase: reductase: fucO [+ 2 isozymes] gldA a hepta-acylated core 2,6-diamino-4- [acp] component malate F6P myristoyl-acyl isocitrate propionyl-CoA citrate-ACP adhE a 1-lysophosphatidylserine an AP (apurinic or sn-glycerol a [DNA]-3'- D-glucopyranose maltotriose PpiD malate 7-phosphate isochorismate ketoacyl-ACP ∆ 5 propionyl-CoA dihydroxyacetone oligosaccharide lipid L-phenylalanyl- a deaminated A H O 2-phosphoglycolate 7,8-dihydro- an apurinic site dIMP dehydrogenase: 1-phosphate cis- -dodecenoyl- carrier protein- carrier protein- succinate dehydroascorbate 3-keto-L- lpdA acetaldehyde apyrimidinic) site hydroxy-5-(N-methyl) vanillylamine ser 2 ypdG mannose-6- succinyl-CoA dehydrogenase: icd transferase: [+ 2 isozymes] a tRNA Phe 3-phosphate hydroxyl malate dehydrogenase, L-glutamine--D- heptose 7- β synthase: (bicyclic form) a [pyruvate dehydrogenase a [pyruvate dehydrogenase glycolaldehyde A (E. coli K-12 type) L-lysyl-[protein] amino group donor 8-oxoguanine within DNA mdh phosphate glucose-1-phosphate -ketoacyl- [acp]:NAD+ dependent dependent synthetase: sucD sucC gulonate-6- 2-methylcitrate citE acetaldehyde dihydroxyacetone created by glycosylic formamidopyrimidine dehydrogenase: NAD-requiring: fructose-6- phosphate Hypothetical c1186 2-methylcitrate E2 protein] N 6 - 6 acetaldehyde [+ 4 isozymes] isomerase: adenylyltransferase: ACP oxidoreductase: fabI acyltransferase: acyltransferase: Succinyl-CoA phosphate synthase: prpC E2 protein] N -S- glycolaldehyde kinase: dhaM bond cleavage maeB maeA phosphate kinase: hldE isochorismatase ∆ synthase: prpC Pyruvate dehydrogenase: adhE β synthase: fabF 3-oxo-cis- 7- lpxM lpxM decarboxylase: dihydrolipoyl-L-lysine acetyldihydrolipoyl-L-lysine D-glycero- -D- manA glgC synthetase: c5037 c5036 a citryl-holo dehydrogenase dehydrogenase: dhaK c1657 3+ 3+ [+ 3 isozymes] aminotransferase: family protein laurate tetradecenoyl- a (5Z)-dodec-5-enoyl-[acp] (2S,3S)-2- (2S,3S)-2- acetaldehyde Fe FecD Fe manno-heptose a (1->4)- [+ 3 isozymes] (KDO) -lipid ulaD [citrate lyase acyl- aldA YhaV endonuclease D-myo-inositol D-mannopyranose yecD: yecD 2 E1 component: α-D-glucopyranosyl- a mature peptidoglycan 2/3-O-Ac-α-L- 1516 1402 β glmS ADP-α-D-glucose (KDO) -lipid A 2,3-dioxo- methylcitrate dehydrogenase: eutE β (n) an intra- a guanine a cytidine 3-hydroxy, 6-cis -D-fructofuranose D-sorbitol (S)-3-hydroxy- 2+ MrdB [acp] 2 methylcitrate DHAP GDP- -L-fucose GDP-L-fucose ATP glutathione maltose maltohexaose lactulose nitrite isethionate a [protein]-L-lysine a uridine in tRNA dihydrolipoamide a phenol sulfate DHAP enol-oxaloacetate a 23S rRNA Fe heme b 1,7-bisphosphate 6-phosphate α-D-glucan short chain A, cold adapted succinyl-CoA 2-oxoglutarate 3-keto-L- carrier protein] aceE diphosphoundecaprenol (meso-DAP containing) Fuc-(1->3)-α- cobinamide D-phenylhydantoin degradation L-homoserine (1,2,3,4,5)- D-glucosamine (2S,3S)-2,3- synthase: fabB Putative beta- L-gulonate 2-methylcitrate protein disulfide in 16S rRNA in 16S rRNA -tridecenoyl-CoA 1-phosphate 6-phosphate isobutanoyl-CoA D-glycero- glycogen Citrate glycolate acetate peptidyl-lysine N- tRNA- Putative substrate mRNA pentakisphosphate phosphomannomutase: dihydroxy-2,3- a 3-oxotetradecanoyl- acyl-CoA ketoacyl-ACP gulonate-6- dehydratase: acetyl-CoA D-Glc-PP-Und 16S rRNA m 2 G1516 16S rRNA m 4 C1402 Dihydrolipoamide Putative 3- fructose-1- oxaloacetate sorbitol-6- Putative heme d oxaloacetate 6-phosphate β 2,3-diketo- phenylhydantoinase: 16 methylglyoxal homoserine ferroxidase: -D-manno- cpsG synthase: dihydrobenzoate [acp] synthetase: a (7Z)-3-oxotetradec- phosphate lyase lactulose acetyltransferase: dihydrouridine dehydrogenase: hydroxyacyl-CoA sulfatase ydeN phosphatase: ribonuclease: keto-enol- phosphatase: crotonase: synthase: c1186 L-gulonate prpD Glycolate acetyl-CoA fucosyltransferase: peptidoglycan lytic cobinamide amylomaltase: nitrite reductase - hyuA isethionate methyltransferase: methyltransferase: racemase: synthase: CvpA phosphoglucosamine heptose-1,7- glgA fadK 7-enoyl-[acp] decarboxylase: alpha phnO synthase: dusC dehydrogenase: precursor: ydeN yqaB synthase: mgsA isomerase: hxpB bfr phosphomannomutase: 2,3-dihydro-2,3- 3-oxoacyl- 3-oxo-cis-∆7- reductase: 2-methyl-trans cis-2- oxidase synthetase (AMP- wcaI exotransglycosylase: mltD fucosyltransferase: adenosyltransferase: oxidized galactohydrolase: NADH dependent: monooxygenase: rsmJ rsmH lpdA yhaV c5023 katE a (1->4)- malQ 2 4 ygeA pyruvate mutase: glmM bisphosphate 7- dihydroxybenzoate ∆ 7 sgbH chain: citF glutaredoxin an N - an N - [+ 4 isozymes] [+ 2 isozymes] c2467 [+ 2 isozymes] [+ 4 isozymes] fumA [+ 4 isozymes] phosphoenol cpsG [ACP] fatty acyl-CoA 3-oxo-cis- - tetradecenoyl-[acp] 2-oxoglutarate yiaK -aconitate methylaconitate acetyl-CoA subunit forming): acs peptidoglycan lytic wcaE btuR lacZ nirD nirB N-carbamoyl-D- ssuD 6 D-myo-inositol 3+ YgjV α-D-glucan 1516 1402 a [protein]-N - a 5,6-dihydrouridine lipoamide 6-cis, 3-oxo- methylglyoxal methylacrylyl-CoA an rRNA fragment Fe heme d D-glucosamine phosphatase: α dehydrogenase: entA citryl-ACP methylguanine methylcytidine a phenol β-D-fructofuranose an mRNA fragment oxaloacetate D-sorbitol (2,3,4,5) pyruvate -D-mannose reductase: synthetase: tetradecenoyl- synthase: fabB dehydrogenase: L-xylulose - (2R,3S)-2- glcD: glcD exotransglycosylase: mltC phenylglycine acetyl-L-lysine tridecenoyl-CoA D-homoserine 1-phosphate gmhB 1,4-α- 3-keto-L-gulonate lyase: citE acetyl-CoA α in 16S rRNA in 16S rRNA in tRNA carboxykinase phosphoenolpyruvate β 1-phosphate 2,3- fabG fadD [acp] sucA sucB lpdA 5-phosphate -L-fucosyl-(1->3)- α-L-Fuc-(1->4) two reduced β tetrakisphosphate D-glycero- -D- glucan methylisocitrate glyoxylate GDP maltoheptaose -D-glucose D-fructofuranose β-D-galactose dihydroxybenzoate a (3R)-3- reductase: fabG β-D-glucopyranosyl- GDP GSSG + glycolaldehyde (ATP): pck synthetase: ppsA glucosamine- manno-heptose mannose-1-phosphate a (7Z)-3-oxotetradec-7-enoyl-[acp] superpathway of phospholipid biosynthesis I (bacteria) [+ 2 isozymes] L-ribulose-5- hydro-lyase: acnB oxaloacetate a mature peptidoglycan GlcNAc-1,6-anhMurNAc- -2/3-O-Ac-α-L- adenosylcobinamide PPP cysteine residues ammonium NAD H O sulfite branching lauroyl-CoA 3-keto-L- cis-2- (n) i 2 FtsK 1-phosphate hydroxytetradecanoyl- a (3R,7Z)-3- diphosphoundecaprenol Fuc-(1->3)-α- in a protein 1-phosphate guanylyltransferase: Enterobactin gulonate phosphate 3- (2R,3S)-2- (meso-DAP containing) L-Ala-γ-D-Glu-DAP-D-Ala enzyme: [acp] hydroxytetradec- 3-oxo-cis-∆ 7 - methylaconitate acetyltransferase: cpsB synthetase [EntB aryl- epimerase: glyoxylate malate D-Glc-PP-Und YegO phosphoenolpyruvate heptose 1-phosphate glgB DHAP kinase: (2R,3S)-2- methylisocitrate glmU component carrier protein] (3R)- 7-enoyl-[acp] tetradecenoyl-[acp] ulaE carboligase: synthase adenyltransferase: mannose-1-phosphate lyxK methylisocitrate N-acetyl-α-D- E: c2433 hydroxymyristoyl- reductase: fabG gcl G: glcB glycerol and glycerophosphodiester degradation hldE guanylyltransferase: a glycogen Enterobactin glycerol-3-phosphate Putative 2-methylisocitrate di-trans,octa-cis hydrogen N-acetyl-9-O- 1915 2069 2030 516 D-ribose 5- D-mannose 3-(4- enolase: eno glucosamine [acyl carrier 3-keto-L-gulonate hydro-lyase: acnB pyruvate fermentation to acetate and lactate II α-Kdo-(2->4)-α-Kdo-(2->6)-lipid IV (KDO) -lipid A a pyrimidine nucleoside maltohexaose a pseudouridine a guanine adenine (2-aminoethyl) a uridine a ribonucleoside a pyrimidine base a single- 2+ β a (3R,7Z)-3-hydroxytetradec- dehydrogenase: gpsA malate A a phosphatidylethanolamine L-1-glycerophosphorylethanolamine -undecaprenyl 2 menadiol glycerophosphoglycerol fumarate an acyl phosphate aminoacetone 13-DPG methylglyoxal L-tartrate Ins(1,2,3,4,5,6)P arsenate Cu ADP-D-glycero- - cpsB 2,3- synthetase hexulose-6- lyase: prpB peroxide acetylneuraminate asp phosphate 6-phosphate hydroxyphenyl) 6 1-phosphate protein] 6-phosphate (2R,3S)-2- tartronate in 23S rRNA in 23S rRNA in 23S rRNA phosphonate in 16S rRNA 3'-phosphate lesion in DNA stranded RNA D-manno-heptose dihydroxybenzoate- component 7-enoyl-[acp] phosphate synthase glycerol diphosphate 3 7 6 (2-aminoethyl) Ribosomal Glyceraldehyde bifunctional -3-hydroxy- OpgC a (2E,7Z)-tetradeca- 23S rRNA m Ψ1915 23S rRNA m G2069 23S rRNA m A2030 Putative D-aminopropanol sugar sugar L(+)-tartrate Arsenate cupric 2-phospho-D-glycerate N-acetylglucosamine- GDP-α-D-mannose dehydratase: fabZ 3-keto-L- methylisocitrate semialdehyde A: aceB a glycerophosphodiester 3-phosphate methylglyoxal ADP-L-glycero-D- [aryl-carrier E: c2433 2,7-dienoyl-[acp] sn-glycerol 3-phosphate isomerase: pyruvate ribosylpyrimidine methyltransferase: methyltransferase: methyltransferase: phosphonate N- dehydrogenase: small subunit 3'-nucleotidase: phosphatase: DNA phosphatase: dehydratase: propionyl-CoA reductase: reductase: YcaD 1-phosphate pyruvate succinate Kdo2-lipid VI menadiol:hydrogen maltohexaose N-acetyl-9-O- acylphosphatase: reductase: ydjG Putative mannoheptose 6- protein] ligase: entE [+ 3 isozymes] [EntF L-seryl- 3-hydroxydecanoyl- gulonate-6- sgbU tartronate A L-1-glycerophophorylethanolamine glycerophosphoglycerol nucleosidase: rihB L-aspartate acetyltransferase: pseudouridine dehydrogenase umpG hxpA glycosylase: hxpA ser 7 glycerol Kdo -lipid A rlmH rlmL rlmJ gldA ttdB ttdA arsC rclA Probable uridyltransferase: cis-∆ - 2-methylisocitrate phosphoethanolamine 2 peroxide glucosidase: malZ acetylneuraminate 3 7 6 c1106 crotonase: epimerase: rfaD UDP-α-D-glucose 2,3- carrier protein] [acyl-carrier- phosphate L-ribulose 5- semialdehyde phosphodiesterase: ugpQ phosphotransferase: phosphodiesterase: ugpQ an N - oxidase: an N - an N - phnO synthase A: rsuA A: c1843 [+ 3 isozymes] nth [+ 3 isozymes] D-myo-inositol phosphoglycerate a holo-[EntB aryl- lyase: prpB Putative lactate (S)-malate glycerophosphodiester kinase: oxidoreductase: ccp esterase: nanS (R)-1- c5023 + glmU dihydroxybenzoyl- protein] tetradecenoyl- acyl-CoA:sn-glycerol- acyl-acp:sn-glycerol- decarboxylase: reductase: glxR 7''-transferase: eptB 1915 nadB 2069 2030 (2-acetamidoethyl) a carboxylate a 16S rRNA D-glyceraldehyde a ribonucleoside acetol an apyrimidinic oxaloacetate an rRNA fragment arsenite Cu ADP-L-glycero-β- biosynthesis I a (2E,7Z)-tetradeca- phosphate phosphodiesterase: ugpQ glpK lpxT methylpseudouridine methylguanine methyladenine aminopropan-2-ol aldehydo-D-ribose D-mannose (1,2,3,4,5)- mutase 2: gpmB UDP-N-acetyl- carrier protein] [acp]:NAD+ 3-phosphate 1-O- 3-phosphate 1-O- ulaD dehydrogenase: a pyrimidine base phosphonate pseudouridine 516 3-phosphate site in DNA 4-coumaryl-CoA D-manno-heptose AMP dehydratase: fabA tartronate D-ribofuranose in 23S rRNA in 23S rRNA in 23S rRNA pentakisphosphate YbiO 2,3-bisphosphoglycerate- α-D-glucosamine D-glucopyranose oxidoreductase: 2,7-dienoyl-[acp] acyltransferase: plsB acyltransferase: plsB L-ribulose-5- c5039 7-O-[2-aminoethoxy(hydroxy)phosphoryl]- D-glucopyranose maltopentaose 3-keto-L- pyruvate succinate semialdehyde a 1,2-diacyl-sn-glycerol ethanolamine sn-glycerol glycerol sn-glycerol 6-phosphate a (2E)-tetradec- ∆ 7 phosphate 4- sn-glycerol α-D-Kdo-(2->4)-α-D-Kdo-(2->6)-lipid IV α-D-Kdo-(2->4)-α- menadione H O acetate N-acetylneuraminate α-iminosuccinate succinate YqaE independent 2,3- a holo-[EntF fabI cis- -tetradecenoyl- acetyl-CoA CO A 3-phosphate di-trans,octa-cis- 2 3-phosphate phosphoglucomutase: 2-enoyl-[acp] gulonate-6- pyruvate fermentation 2 reductase: garR D-Kdo-(2->6)-lipid phosphoglycerate dihydroxybenzoate- L-seryl-AMP L-seryl-carrier [acp]:NAD+ epimerase: 3-phosphate undecaprenyl phosphate pgm a (7Z)-tetradec- a 2-lysophosphatidate a 2-lysophosphatidate phosphate to acetate IV (S)-lactate A 1-diphosphate mutase: gpmM α-D-glucose protein] myristoyl- oxidoreductase: fabI araD phosphate D-glycerate [aryl-carrier 7-enoyl-[acp] decarboxylase: 1-phosphate protein] ligase: entE [acyl-carrier- [+ 2 isozymes] acetyltransferase: pta 3-phospho-D-glycerate enterobacterial common antigen biosynthesis ∆ a (7Z)-tetradec-7-enoyl-[acp] sgbH pyruvate glycerate protein] 3-oxo-cis- 9- acyl-CoA:1-acyl-sn- acyl-[acp]:1-acyl-sn- D-xylulose phosphate a 5'-deoxyribose- RNase R degradation 2-carboxymethyl-3- 3-[(3aS,4S,5R,7aS)-5- a guanosine 18 a uridine 2604 ethyl-2- D-glucose 6- (E) 1- D-glucopyranose D-galactaro- Psd UTP--glucose- L-xylulose - cellulose + an L-methionyl- maltoheptaose lipid IV 1,2-dipalmitoyl- a 2,3- reductase: fabI hexadecenoyl- 5-phosphate acetyltransferase: 2-kinase: a phosphatidylethanolamine (deoxynucleotides) NAD [DNA] 5-phosphate- (R)-phenyllactate (E)-cinnamoyl-CoA A hydroxy-7a-methyl-1-oxo- (S)-5-hydroxyisourate methionol 2-oxoglutaramate ser isovaleryl-CoA pantetheine DHAP a reduced flavin D-tartrate 3',5'-ADP glycerol-3-phosphate 2- glycerol-3-phosphate 2- DHAP (m) substrate RNA Met hydroxyphenylpropionyl-CoA in tRNA in 23S rRNA methylacetoacetate phosphate cys propenylsulfenate 6-phosphate 1,5-lactone YebO phosphoglycerate 1-phosphate 3-oxo-cis-∆9- 5-phosphate glxK [initiator tRNA ] phosphatidylserine α-D-glucose 1-phosphate dihydroxybenzoyl- a seryl-[EntF [acp] O-acyltransferase: plsC O-acyltransferase: plsC Pyruvate formate- eutD [DNA] Putative 3- octahydro-1H-inden-4-yl]- tRNA (Gm18) 2'-O- 23S rRNA Putative alcohol isovaleryl-CoA sugar β-keto ester Putative sugar D-tartrate 3'(2'),5'- kinase: pgk uridylyltransferase: a myristoyl-[acp] hexadecenoyl- 10-formyltetrahydrofolate:L- 5-hydroxyisourate 2-oxoglutaramate 3-hydroxy acid pantetheine L-cysteine [EntB aryl- L-seryl-carrier synthase: fabB L-ribulose-5- lyase 2 activating glycerate hydroxyacyl-CoA 3-hydroxypropanoyl-CoAPutative 3- 2604 phosphatase: flavin:NADH phosphatase: galU superpathway of acetate celulose fMet methyltransferase: pseudouridine dehydrogenase: dehydrogenase: reductase: dehydratase: desulfhydrase: bisphosphate UDP-N-acetyl-α-D-glucosamine dTDP-glucose carrier protein] protein] [acp] synthase: fabB phosphate 3- enzyme: pflC acetyl phosphate 2-kinase: DNA repair Flavodoxin methionyl-tRNA N- maltoheptaose dehydrogenase: hydroxyacyl-CoA hydrolase: hiuH amidase: yafV dehydrogenase kinase: coaA hxpA reductase hxpA 13-DPG β Putative beta- utilization and formation phosphoethanolamine DNA-5'-terminal RNase R: rnr trmH synthase: rluF c0762 aidB dkgA fumB malY nucleotidase: pyrophosphorylase: UTP--glucose- -ketoacyl- Putative beta- epimerase: garK protein radC: radC 1: fldA formyltransferase: fmt glucosidase: malZ c2467 dehydrogenase: (S)-2-oxo-4- a 2'-O- YdfG: ydfG ycdH: c1144 UDP-N- ketoacyl-ACP [+ 4 isozymes] deoxyribophosphodiesterase: an N-formyl- a pseudouridine 2604 3-methylcrotonyl- [+ 3 isozymes] ethyl-(2R)-methyl-(3S) [+ 3 isozymes] cysQ (Z)-propanethial D-galactaro- 1-phosphate ACP D-gluconate transferase: bcsG 18 [+ 4 isozymes] RcsD rffH ketoacyl-ACP ulaE acetate [+ 2 isozymes] mutM benzoylsuccinyl- 3-[(3aS,4S,5R,7ac2467S)-5- hydroxy-4-carboxy- methylguanosine 3-methylthiopropanal 2-oxoglutarate aminoacetaldehyde 4'-phosphopantetheine an oxidized flavin oxaloacetate F6P Glyceraldehyde acetylglucosamine synthase: acetate 2-phospho- L-methionyl- in 23S rRNA CoA dihydroxyacetone -hydroxybutanoate D-glucose pyruvate AMP S-oxide 1,4-lactone YeaY uridylyltransferase: synthase: fabF synthase: c1186 degradation kinase: ackA acetyl-CoA CoA hydroxy-7a-methyl-1-oxo- 5-ureidoimidazoline in tRNA 3-phosphate di-trans,octa-cis- 2-epimerase: wecB α c1186 a phosphatidate Putative D-glycerate [initiator tRNA met ] 2-palmitoyl- dTDP- -D-glucose galF an N-(2,3- [+ 3 isozymes] acetyl-CoA formate synthetase a 1,2-diacyl- phosphoethanolamine (R)-phenyllactyl- D-glucopyranose maltohexaose lipid IV octahydro-1H-inden-4- hexulose-6- trans-cinnamate a diribonucleotide a nucleoside 5'- sn-glycero-3- B dehydrogenase undecaprenyl phosphate UDP-N-acetyl-α-D-glucosamine α a (9Z)-3-oxohexadec- D-gluconate acetate (AMP- cellulose AMP (deoxynucleotides) NMN 4-hydroxy- UDP-N-acetyl- -D-mannosamine dihydroxybenzoyl)- a (9Z)-3-oxohexadec-9-enoyl-[acp] acetate sn-glycerol (m) a 5'-phospho- CoA yl]-3-oxopropanoyl-CoA A: c1843 dTDP-glucose 4,6- UDP-α-D-glucose a 3-oxohexadecanoyl- CTP:phosphatidate phosphate D-gluconate phosphate kinase: 2-pentenal- monophosphate phosphoserine seryl-[EntF L-seryl- 9-enoyl-[acp] forming): acs [DNA] UDP-N-acetyl-D- dehydratase: rffG [acp] 9 cytidyltransferase: cdsA isomerase: kinase: idnK acetyltransferase: pta ackA 5-phosphate glyceraldehyde- UDP-N-acetylglucosamine--undecaprenyl- 9 3-oxo-cis-∆ - carrier protein] 3-oxo-cis-∆ - sgbU YnaI triose- 3-phosphate phosphate N- mannosamine dTDP-4-dehydro-6- 3-oxoacyl- hexadecenoyl-[acp] D-gluconate phosphate RclC hexadecenoyl- a CDP-diacylglycerol dehydrogenase: deoxy-α-D-glucopyranose L-ribulose 5- acetyltransferase: acetyl phosphate acetyl-CoA 3 phosphate dehydrogenase: acetylglucosaminephosphotransferase: rfe [ACP] reductase: fabG kinase: gntK β α 2605 a medium-chain RNase G [acp] D-gluconate an N - ADP-L-glycero- - -Kdo-(2-> a dimer of adjacent 2'- (S)-3-hydroxy-(9Z) L-dehydro- a 23S rRNA 3-hydroxy- 5-cis, 7-trans uridine 2-methyl-1,4- D-glyceraldehyde a secondary α D-glucosamine α-D-glucose wecC phosphate eutD glycerophosphoglycerol a 1-lysophosphatidylethanolamine hν glutathione maltopentaose glutathione maltohexaose trans-aconitate N-ethylmaleimide an arylamine 2-methylbutanol -ribazole (S)-NADPHX xanthine diacetyl isomerase: gapA dTDP-4-dehydro- reductase: 2-oxoglutarate methylcytosine D-manno-heptose 4)-α-Kdo-(2- 1911/1915/1917 2,3,4-saturated degradation ser α reductase: fabG a (3R,9Z)-3-hydroxyhexadec- 6-phosphate deoxycytidines in DNA -hexadecenoyl-CoA ascorbate uridine -tetradecadienoyl-CoA in 23S rRNA benzoquinone 3-phosphate alcohol 5'-phosphate 6-phosphate 6-phosphate tpiA D-glyceraldehyde UDP-N-acetyl- -D- 6-deoxy-D-glucose fabG a (3R,9Z)-3- CDP-diacylglycerol--glycerol- phosphatidylserine L-ribulose-5- in DNA >6)-lipid IV 3-hydroxyacyl-CoA 23S rRNA Putative 3- fatty acyl CoA sugar substrate mRNA Possible DHAP lipid I enterobactin 9-enoyl-[acp] A trans-aconitate 2- 23S rRNA arylamine N- NAD(P)H:quinone Putative alcohol Putative alcohol α-ribazole-5'-P (S)-NADPHX serine diacetyl mannosaminouronate transaminase: wecE a (3R)-3- synthase: pssA acetyl phosphate 1911/ N-ethylmaleimide Putative acyl-coa 3-phosphate hydroxyhexadec- 3-phosphate 3- phosphate 4- dehydrogenase: fadB pseudouridine hydroxyacyl-CoA methyltransferase: pseudouridine 2605 oxidoreductase: dehydrogenase: phosphatase: ribonuclease: hypoxanthine reductase: glutathione-specific γ- maltopentaose maltodextrin acetyltransferase: dehydrogenase: dehydrogenase: phosphatase: dehydratase: deaminase: YfgM hydroxyhexadecanoyl- phosphatidyltransferase: epimerase: glycerophosphoglycerol N3- ADP-heptose:Kdo deoxyribodipyrimidine 3-hydroxyacyl-CoA oxidized 1915/1917 dehydrogenase: reductase: nemA hxpA oxidase RbbA dTDP-thomosamine 9-enoyl-[acp] phosphate 2 phosphorylase: tam synthase: rluB nhoA qorB c0762 c0762 rng cobC nnr tdcG ucpA UDP-N-acetyl-D- [acp] pgsA araD acyltransferase: pldB methylcytosine -lipid IV - glutamylcyclotransferase: glucosidase: malZ c2464 a phosphatidylserine acetate kinase: ackA acetyltransferase: pta A photolyase: phr dehydrogenase: fadJ glutaredoxin synthase: rluD malP c2467 (E)-3- a pseudouridine 2605 an N- methyl-1,4- [+ 3 isozymes] xdhD: c3459 D-galactosamine mannosaminuronic dTDP-4-amino-4,6- (3R)- demethylase: alkB heptosyltransferase: chaC a pseudouridine 1911/ 5-cis, 7-trans-3-oxo- N-ethylsuccinimide a medium-chain 2-methylbutanal a ketone a single- α-ribazole NADPH [+ 3 isozymes] (S)-acetoin F6P [+ 2 isozymes] phosphate 3-oxo-(9Z)-hexadecenoyl-CoA (methoxycarbonyl) in 23S rRNA acetylarylamine benzoquinol D-glyceraldehyde urate 6-phosphate acid transferase: rffM dideoxy-D-galactose hydroxymyristoyl- a (2E,9Z)-hexadeca- waaC 1915/1917 in 23S rRNA tetradecadienoyl-CoA (2E)-2-enoyl-CoA stranded RNA pyruvate Putative UDP-α-D-galactose D-xylulose acetyltransferase: pent-2-enedioate acyltransferase: rffC [acyl carrier 2,9-dienoyl-[acp] a phosphatidylglycerophosphate acetate two adjacent 2'- D-glucopyranose maltotetraose α-D-glucose aldolase: a (2E,9Z)-hexadeca- 5-phosphate eutD L-1-glycerophosphorylethanolamine a lysophosphatidylglycerol L-ascorbate GSSG maltopentaose biosynthesis protein] a cytosine in DNA formaldehyde succinate heptosyl- deoxycytidines in DNA 5-oxo-L-proline L-cysteinyl-glycine 1-phosphate c4284 lipid II dTDP-N-acetylthomosamine 2,9-dienoyl-[acp] palmitoleoyl- ADP MreD OpgH phosphatidylglycerophosphatase: Kdo -lipid IV α dehydratase: fabZ [acp]:NAD+ a phosphatidylethanolamine 2 A [+ 4 isozymes] UDP- -D-glucose palmitoleoyl- pgpB UDP-glucose 4- 3-hydroxydecanoyl- oxidoreductase: fabI TDP-N-acetylfucosamine:lipid II [acp]:NAD+ [+ 2 isozymes] [acyl-carrier- 3 6 epimerase: galE N-acetylfucosaminyltransferase: an N - 6 an N -L- a 2'- 1939 747 RNase E GDP-4-dehydro- dTDP-4-dehydro- oxidoreductase: superpathway of pyrimidine Nucleoside and Nucleotide Degradation an aminated amino 1-18:1-2-18:1- an N -(1-hydroxy-2- (S)-3-hydroxy-(7Z) a uracil a long-chain (3S)- a uracil (Z)-3- L-glyceraldehyde 3-hydroxyadipyl- D-galactopyranose α protein] a palmitoleoyl-[acp] uracil degradation III quercetin 2-oxoglutarate 2-oxobutanoate 37 a phosphatidylglycerol spermidine Ins(2)P hydroxypyruvate 3-methylbutanol isobutanal degradation estrone-sulfate riboflavin α α -D-glucose UDP-glucose 4- wecF fabI a phosphatidylglycerol deoxyribonucleosides degradation purine nucleotides degradation II (aerobic) methylcytosine group donor phosphatidylethanolamine oxopropyl)-[protein]-L-lysine -tetradecenoyl-CoA threonylcarbamoyladenine deoxyribonucleoside in 23S rRNA 3-hydroxyacyl-CoA in 23S rRNA peroxyaminoacrylate 3-phosphate CoA -D-rhamnose 6-phosphate 6-deoxy- -D- fructose 1,6- dehydratase: fabA dGMP GDP-L- epimerase: c2560 in RNA 3-hydroxyacyl-CoA in tRNA 5'-monophosphate lipid 5 3-hydroxyacyl-CoA 5 8 sugar substrate mRNA glucopyranose YjbA α 6 6 deoxyribonucleoside 23S rRNA m U1939 23S rRNA m U747 spermidine N - aminoacrylate inositol Putative alcohol isobutyraldehyde riboflavin Putative YdgO bisphosphate UDP- -D-galactose a palmitoleoyl-[acp] 2'-deoxycytidine uracil dehydrogenase: fadB tRNA m t A37 dGMP 5'-phosphate dehydrogenase: hydroxypyruvate phosphatase: Arylsulfatase: fucose lipid III a (2E)-hexadec- 3-oxo-cis-vaccenoyl- cardiolipin synthase: clsA AMP 2-oxobutanoate 5'-monophosphate kinase: methyltransferase: methyltransferase: acetyltransferase: peracid monophosphatase: dehydrogenase: reductase: ybbO ribonuclease: reductase: crotonase: cardiolipin synthase: clsC N3- protein deglycase: hchA methyltransferase: phosphohydrolase: fadB isomerase: hyi aslA synthase: fructose-1,6- 2-enoyl-[acp] quercetin 2,3- 3-hydroxyacyl-CoA yegS rlmD speG reductase: rutC c0762 hxpA [+ 3 isozymes] rne fre c5023 [acp] synthase: fabF cardiolipin synthase: clsB C1 Compound Utilization and Assimilation deoxycytidine aminotransferase: trmO phosphatase: yfbR umpG rlmC suhB bisphosphatase: fbp uracil oxygenase: rutA dioxygenase: yhhW methylcytosine protein deglycase: yajL 6 1939 747 8 2,3- fcl lipid III flippase: wzxE dehydrogenase: fadJ an N -methyl- a 5-methyluracil [+ 2 isozymes] a 5-methyluracil N - tartronate [+ 3 isozymes] D-tagatofuranose dTDP-4-dehydro- keto-D-fructose palmitoyl- [+ 2 isozymes] deaminase: cdd IMP avtA 5'-deoxynucleotidase: a phosphatidylglycerophosphate [+ 2 isozymes] a long-chain 3- aminoacrylate 3-methylbutanal isobutanol a single- estrone reduced riboflavin β [+ 2 isozymes] UDP-N-acetyl-D- 3-oxo-cis- palmitoleate demethylase: alkB 3-oxo-(7Z)-tetradecenoyl-CoA threonylcarbamoyladenosine in 23S rRNA in 23S rRNA acetylspermidine myo-inositol semialdehyde L-glyceraldehyde didehydroadipyl- GDP- -L-fucose 6-phosphate β-L-rhamnose [acyl-carrier- formaldehyde oxidation thymidine yfdR oxoacyl-CoA stranded RNA antimonous acid antimonous acid galactosamine UDP-α-D-glucuronate vaccenoyl- superpathway of purine deoxyribonucleosides degradation 37 in tRNA a 2'- 2'-deoxyguanosine CoA F6P lipid III protein] Ptd Gro II (glutathione-dependent) reductive formate 2'-deoxyuridine GMP inosine 5'- FMN-N5-oxide 3-ureidoacrylate 1-18:1- urea urea YbhQ biosynthesis I [acp] an (11Z)-3-oxooctadec- 2 a deaminated (R)-lactate deoxyribonucleoside GlpF biosynthesis (from reductase: fabI monocarboxylic oxidation thymidine 2-protocatechuoylphloroglucinolcarboxylate carbon monoxide succinate (S)-2- oleate a [protein]-L-lysine UDP-N-acetyl- palmitoleate synthase: fabF 11-enoyl-[acp] adenosine monophosphate formaldehyde a cytosine in RNA amino group donor lysophosphatidylethanolamine DL-glyceraldehyde DL-glyceraldehyde glucose-6- α UDP-glucose) acid cycle to CO phosphorylase: aminobutanoate -D-glucosamine phosphatidylglycerol formaldehyde 2 guanosine-5'- dehydrogenase: ureidoacrylate [+ 3 more] [+ 3 more] phosphate UDP-glucose UDP-α-D-glucose a palmitoyl-[acp] [+ 2 isozymes] deoA 2'-deoxyguanosine 3-oxo-cis-vaccenoyl- biosynthesis II (non-plastidic) acetyl-CoA formate phosphate guaB amidohydrolase: rutB isomerase: pgi 4-epimerase: adenosine UDP-glucose 6- [acp] reductase: fabG thymidine 2'-deoxyadenosine phosphohydrolase: molybdate molybdate c2560 FMN α-D-Gal-(1->3)-α-L-Fuc- a [DNA]- 1518 an N-terminal L- N-acetyl-α- 55 (R)-3- GDP-4-dehydro- UDP-6-deoxy- thiosulfate/ D-glucopyranose α dehydrogenase: ugd an (11Z)-3-oxooctadec- DHAP deaminase: add 1-18:1- + a dimer of adjacent (S)-3-hydroxy-(5Z) adenine / an N-hydroxy- 3-(4-hydroxyphenyl)-3- 2,6- (2R,3S)-3- a uridine D-glucopyranose 2-benzyl-2- a double UDP-N-acetyl- - S-hydroxymethylglutathione Uridine phosphorylase: yrfG XMP a 2-lysophosphatidylethanolamine NAD H O hν 2,3- spermidine indole-3-glycol 8-oxo-dGDP an mRNA D-tagaturonate thiosulfate thiosulfate WecH α glt 2 (1->4)-2/3-O-Ac-α-L-Fuc- nucleotide- 1519 alanyl-[S18 protein neuraminate L-dopa hydroxybutanoyl- α-D-rhamnose 5,6-ene-N-acetyl- sulfate ABC 6-phosphate D-galactosamine UDP- -D-glucuronate 11-enoyl-[acp] a (3R,11Z)-3-hydroxyoctadec- glycerol-3-phosphate Pyruvate phosphorylase: ppnP carbamate aminoacrylate lysophosphatidylethanolamine thymidines in DNA -dodecenoyl-CoA adenine in 16S rRNA diaminopropanoate arylamine hydroxy-propionyl-CoA dimethoxyphenol isopropylmalate in tRNA 6-phosphate hydroxybutanedioate stranded DNA selenite selenite deoxyguanosine [+ 3 isozymes] 6 N-acetylneuraminic 11-enoyl-[acp] CO (1->3)-α-D-Glc-PP-Und 3-hydroxyacyl-CoA 3'-phosphate 16S rRNA m of 30S ribosome] Putative 3- 1 sugar CoA D-glucosamine transporter dehydrogenase: gpsA S-(hydroxymethyl) formate-lyase 2 udp galactosyl-(1->3)-L-fucosyl- 3'-phosphomonoesterase: 2 ribosomal-protein- N-hydroxyarylamine spermidine N - 3-isopropylmalate tRNA Putative alcohol 8-oxo-dGDP mRNA selenate selenate 3-oxo-cis- formaldehyde phosphorylase: inosine 5'-nucleotidase: 6 2,3- acid outer 4,5-DOPA Putative gyrase: thymine deoxyadenosine aminoacrylate dehydrogenase: fadB A1518,m A1519 hydroxyacyl-CoA 55 phosphatase: palmitate (1->4)-O-acetyl-L-fucosyl- xthA 2 S18-alanine N- O-acetyltransferase: acetyltransferase: dehydrogenase: pseudouridine dehydrogenase: diphosphatase: interferase: vaccenoyl- (3R)- sn-glycerol 3-phosphate glutathione 2 activating oxidation uracil deaminase: add deoD guanosine umpG 1-acyl diaminopropionate membrane dioxygenase crotonase: gyrB gyrA hydrolase: rutD 1-acyl Putative glutamate (1->3)-β-D-glucopyranosyl- deoxyribodipyrimidine 3-hydroxyacyl-CoA dimethyltransferase: acetyltransferase: nhoA dehydrogenase: speG leuB synthase: truB c0762 hxpA mutT higB [acp] hydroxymyristoyl- dehydrogenase: frmA enzyme: pflC IV (thiol- phosphorylase: deoxyadenosine inosine [+ 2 isozymes] lysophospholipase: 3'-phosphomonoesterase: ammonia-lyase: ygeX channel: nanC extradiol: ygiD c5023 short chain lysophospholipase: pldB photolyase: phr 6 rsmA 1518 c2467 1 55 GDP-4-dehydro-6- phosphorylase: pldB dehydrogenase: diphosphoundecaprenol dehydrogenase: fadJ N -dimethyladenine an N-terminal N-acetyl-rimI an N- 3,3',5,5'- N - 4-methyl-2- β a pseudouridine indole-3- [+ 3 isozymes] 2-benzyl-3- a negatively UDP-6-deoxy- D-fructuronatemagnesium hydrogenphosphate magnesium hydrogenphosphate reductase: [acyl carrier protein] acyl-CoA:sn-glycerol- [+ 4 isozymes] independent) deoA phosphorylase: guanosine nfo 4-hydroxybenzoyl- N-acetyl- - 8-oxo-dGMP an mRNA fragment L-deoxygalactose YgiY acyl-CoA S-formylglutathione deoxyinosine CO malonate semialdehyde c0018 3-oxo-(5Z)-dodecenoyl-CoA a [DNA]-3'- 6 1519 pyruvate 4,5-seco-dopa crotonyl-CoA fabG dehydratase: fabZ formaldehyde deoD xanthosine 2 2-O-Ac-α-D-Gal-(1->3)-acetyltransferase:α- wcaB /N -dimethyladenine L-alanyl-[S18 protein acetoxyarylamine tetramethoxydiphenoquinone acetylspermidine oxopentanoate neuraminate in tRNA glycol aldehyde D-glucopyranose hydroxybutanedioate supercoiled DNA 5,6-ene-GalNAc calcium hydrogenphosphate calcium hydrogenphosphate synthetase: 3-phosphate 1-O- 2'-deoxyinosine phosphorylase: xapA phosphorylase: hydroxyl acetyl-CoA PitA a (3R,11Z)-3- 3-hydroxydecanoyl- acyltransferase: plsB malonic L-Fuc-(1->4)-2/3-O-Ac-α-L- two adjacent in 16S rRNA of 30S ribosome] zinc hydrogenphosphate zinc hydrogenphosphate fadK S-formylglutathione deoD [+ 2 isozymes] xapA a carboxylate L-1-glycerophosphorylethanolamine hydroxyoctadec- [acyl-carrier-protein] pyruvate semialdehyde L-1-glycerophosphorylethanolamine oleate Fuc-(1->3)-α-D-Glc-PP-Und thymidines in DNA [+ 2 more] [+ 2 more] hydrolase: frmB [+ 2 isozymes] 2-oxoglutarate ammonium NADH H + fatty acyl-CoA 11-enoyl-[acp] a 2-lysophosphatidate dehydratase: fabA S-formylglutathione formate 2-deoxy-α-D- hypoxanthine xanthosine reductase: ydfG synthetase: α (3R)- uracil 2-deoxy- - phosphorylase: malonic a nucleoside YegT a nucleoside fadD a (2E,11Z)-octadeca- acyl-CoA:1-acyl-sn- hydrolase: yeiG ribose 1-phosphate guanine YbjO hydroxymyristoyl- D-ribose 1- xapA semialdehyde 2,11-dienoyl-[acp] glycerol-3-phosphate 2- deoxyribose 1,5- 32 an [L-cysteine an N-terminal L- 967 65 α a 2'- UDP-4-dehydro- [acyl carrier formate phosphate pyrimidine a cytosine (3S,6Z,9Z,12Z,15Z,18Z,21Z)-3- long chain a nucleoside (2E,6Z,9Z,12Z,15Z,18Z,21Z) a cytosine a double-stranded 7,8- 2,3-diphospho- a uridine a 1,2-diacyl- -D-mannose OPC6-3- a (1->4)- N-acetyl-D- palmitoyl-CoA O-acyltransferase: plsC hypoxanthine xanthosine reductase: rutE a 1-lysophosphatidylethanolamine a 2'-deoxyribonucleotide (deoxynucleotides) D-glucopyranose maltopentaose isoprimeverose alanyl-[S5 protein putrescine 1,3-propanediol a quinone ethanol a β-lactam deoxyribonucleoside methylglyoxal α phosphomutase: (m) in tRNA desulfurase]-S- hydroxytetracosahexaenoyl-CoA -tetracosaheptaenoyl-CoA in 16S rRNA oligonucleotide dihydroneopterin D-glycerate sn-glycerol 1-phosphate hydroxyacyl-CoA α-D-glucan 6-deoxy- - mannosamine protein] cis-vaccen-2-enoyl- deoxyribose 1,5- ribonucleosides polyphosphate triphosphate in tRNA deoB hydroxylase: guanine phosphorylase: sulfanyl-L-cysteine 3-hydroxyacyl-CoA of 30S ribosome] 5 sugar 3'-monophosphate D-glucose dehydratase: fabZ a phosphatidate phosphomutase: degradation 3-hydroxypropanoate nucleoside triphosphate enoyl-CoA ribosomal-protein- 16S rRNA m C967 diamine N- 1,3-propanediol Probable tRNA FMN dependent Putative alcohol β-lactamase: Putative α [acp] reductase: fabI xdhC xdhA xdhB deaminase: guaD ppnP dehydrogenase: Oligoribonuclease: dihydroneopterin diacylglycerol glyoxalase: -amylase: Detoxification deoB cytidine 2-deoxy-D-ribose hydratase: fadJ S5-alanine N- methyltransferase: acetyltransferase: dehydrogenase: phosphoglycerate pseudouridine 65 NADH:quinone dehydrogenase: phosphatase: ampC crotonase: 3-hydroxydecanoyl- 32 amylomaltase: isoprimeverose exopolyphosphatase: ppx pyrophosphohydrolase: yjeR epimerase: folB kinase: dgkA hchA amyA 5-phosphate 2-acyl DNA repair tRNA cytosine 2- fadB [+ 2 isozymes] acetyltransferase: synthase: truC reductase,: azoR c0762 hxpA [+ 2 isozymes] c5023 FtsA [acyl-carrier- CTP:phosphatidate 2-deoxy-D-ribose cytidine malQ α-xylosidase: yicI mazG rsmB speG yqhD mutase 2: gpmB a cis-vaccenoyl-[acp] lysophospholipase: pldB protein radC: radC sulfurtransferase: 967 65 a (1->4)- N-acetyl-D- cytidyltransferase: cdsA reactive oxygen species degradation deaminase: cdd xanthine [+ 2 isozymes] (3S,6Z,9Z,12Z,15Z,18Z,21Z)-3- an N-terminal N-acetyl-rimJ a 5-methylcytosine a nucleoside 5'- 7,8- 3-phospho- a pseudouridine [+ 3 isozymes] a substituted OPC6-trans- UDP-4-dehydro- protein] 5-phosphate (6Z,9Z,12Z,15Z,18Z,21Z)-3- long chain a nucleoside 5'- N-acetylputrescine 3-hydroxypropanal a semiquinone acetaldehyde a phosphatidate a 2'- (R)-lactate α-D-glucan glucosamine 8-oxo-(d)GTP detoxification I arginine dependent uridine deoxyribose- ttcA hydroxytetracosahexaenoyl-CoA in 16S rRNA dihydromonapterin D-glycerate in tRNA D-mannose β-amino acid 2-enoyl-CoA β-L-rhamnose dehydratase: fabA oxotetracosahexaenoyl-CoA polyphosphate monophosphate L-alanyl-[S5 protein monophosphate deoxyribonucleoside a CDP-diacylglycerol acid resistance phosphate xanthine:NAD+ purine ribonucleosides degradation superoxide deoxyribose- Uridine maltose maltotetraose D-glucopyranose α-D-xylopyranose of 30S ribosome] a (2E,11Z)-octadeca- aldolase: deoC oxidoreductase: a carboxylate a 2-thiocytosine 32 an [L-cysteine phosphate phosphorylase: L-1-glycerophosphorylethanolamine a 2'-deoxyribonucleotide CDP-diacylglycerol--glycerol- dGTP in tRNA desulfurase]- 2,11-dienoyl-[acp] GTP arg udp xdhC xdhA xdhB IspZ cis-vaccenate 3-phosphate 3- superoxide dismutase: sodA aldolase: L-cysteine cis-vaccen-2- arginine decarboxylase, adenosine phosphatidyltransferase: superoxide dismutase: sodB deoC uridine acetaldehyde D-glyceraldehyde 3-phosphate urate enoyl-[acp] degradative: adiA pgsA phosphorylase: α reductase: fabI 8-oxo-dGTP 8-oxo-GTP acetaldehyde adenosine a 2-methylthiocytosine 32 glucosyl-(heptosyl) - UDP-α-D-glucuronate a [protein]-L- a double DNA combined with a cytidine 34 in a uridine 38- 3-β-hydroxyandrost- a uridine 13 an aliphatic GDP- -D- OPC4-3- 2,3- 2'-deoxycytidine β-1,4-D- hydrogen peroxide arginine decarboxylase, D-glyceraldehyde ppnP 3 β-D-glucose maltohexaose c-di-GMP glycolaldehyde chitin 2-oxoglutarate a phosphatidylethanolamine 2-hydroxy-dATP 4-aminobutanal exogenous DNA to form met tellurite spermine cyclic-AMP acetaldehyde mannose oxalyl-CoA (S)-NADHX 3'-monophosphate biosynthetic: speA acetaldehyde 3-phosphate dehydrogenase: deaminase: in tRNA Kdo -lipid A-phosphate β-isoaspartate stranded DNA [elongator tRNA ] 40 in tRNA 5-en-17-one 3-sulfate in tRNA α,ω-diamine hydroxyacyl-CoA dihydroxybenzoate mannobiose a phosphatidylglycerophosphate 2 GDP- a cis-vaccenoyl-[acp] 8-oxo-dGTP 8-oxo-GTP- agmatine uracil adhE xanthosine adenosine add c-di-GMP oxidized nucleoside a recombinational junction Met γ tRNA cytidine tellurite diamine N- tRNA cAMP tRNA glycolaldehyde acetaldehyde diamine oxalyl-CoA Putative (S)-NADHX YhfC catalase: katG diphosphatase: diphosphatase: acetaldehyde L-isoaspartate protein exodeoxyribonuclease phosphodiesterase: triphosphate -aminobutyraldehyde 38- Arylsulfatase: 13 mannose 4,6- phosphatidylglycerophosphatase: acetaldehyde pyrimidine deoxyribonucleotides dephosphorylation resolvasome: acetyltransferase: methyltransferase: acetyltransferase: pseudouridine phosphodiesterase: pseudouridine reductase: yqhD dehydrogenase: transaminase: decarboxylase: crotonase: dehydratase: [+ 2 isozymes] mutT mutT dehydrogenase: 2-methylthiocytosine carboxylmethyltransferase: pcm amylomaltase: V: recC recB recD pdeL pyrophosphohydrolase: dehydrogenase: patD aslA dehydratase: dehydrogenase: inosine guanosine ruvC ruvB ruvA tmcA tehB speG 40 synthase: truA cpdA synthase: truD aldB patA oxc c5023 nnr pgpB adhE dCTP β malQ gmd β dethiomethylase: alkB a protein L- - [+ 5 isozymes] nudG resolution of recombinational 4 34 38- 13 ω 2'-deoxycytidine -D-mannosyl- [+ 2 isozymes] H O hydroxyl radical 8-oxo-dGMP 8-oxo-GMP eutE xanthosine adenosine an N -acetylcytidine 1 a pseudouridine a pseudouridine ethylene glycol an aliphatic - GDP-4-dehydro- OPC4-trans- a chitodextrin 2 acetaldehyde pyrophosphohydrolase: nudI isoaspartate a 5'-phosphooligonucleotide 5'-phosphoguanylyl(3'->5') 4-aminobutanoate methanetelluronate N -acetylspermine dehydroepiandrosterone AMP acetate formyl-CoA NADH 2-carboxymuconate (1->4)-D-glucose O adenosine phosphorylase: phosphorylase: 2-hydroxy-dAMP junction formation in [elongator tRNA met ] 40 in tRNA in tRNA aminoaldehyde α-D-rhamnose 2-enoyl-CoA 2 guanosine cis-vaccenate a phosphatidylglycerol dehydrogenase: acetyl-CoA nucleoside triphosphate α-methyl ester nucleotides xapA ppnP inosine guanosine 32 glucosyl-(heptosyl) - of two intact strands a 2-thiocytosine 3 UDP maltopentaose maltose eutE pyrophosphohydrolase: formaldehyde succinate a 2-lysophosphatidylethanolamine a fatty acid YgiH degradation III xanthosine adenosine phosphorylase: phosphorylase: glucosyluronate-Kdo mazG in tRNA 2 xapA xapA -lipid A-phosphate acetyl-CoA AMP dCTP dCMP phosphorylase: phosphorylase: AMP ppnP deoD [+ 2 isozymes] [+ 2 isozymes] nucleosidase: dUTP diphosphatase: dut 1,N 6 - α-L-fucosyl-(1->3)- 3-phospho- a 5' triphospho- 3-methoxy-4- (S)-3- 4-(4-deoxy-α-D- a 5' diphospho- D-sedoheptulose OPC8-3- 2'-deoxyuridine 3'- S-methyl-5'-thioadenosine α-D-ribose- lipid A-core a phosphatidylethanolamine a phosphatidylethanolamine 2-oxoglutarate trans-dienelactone glutathione a cytosine in DNA 2-phenylethanol putrescine 13-DPG a tRNA uridine 32 a quinone L-idonate isobutanol D-glucosamine nitric oxide an mRNA D-altropyranose cellulose amn [+ 2 isozymes] ethenoadenine β-D-glucopyranosyl- hydroxypyruvate [mRNA] hydroxyphenylglycol hydroxytetradecanoyl- galact-4-enuronosyl) [mRNA] 7-phosphate hydroxyacyl-CoA monophosphate YijD degradation IV 1-phosphate dUTP dUMP in DNA Putative diphosphoundecaprenol S-adenosyl-L- Putative alcohol CoA -D-galacturonate DNA-cytosine RNA putrescine Probable tRNA sedoheptulose- Quinone L-idonate 5- Putative alcohol Putative nitric oxide AMP α-L-fucosyl-(1->3)- RNA 3-hydroxyacyl-CoA Putative Putative alcohol glucosamine S-methyl-5'- α-D-ribose 1,5- 3-phosphohydroxypyruvate 32 nucleosidase: carboxymethylenebutenolidase: β methionine:glutathione pyrophosphohydrolase: dehydrogenase: methyltransferase: phosphohydrolase: dehydrogenase: aminotransferase: phosphoglycerate pseudouridine 7-phosphate oxidoreductase: dehydrogenase: dehydrogenase: crotonase: dioxygenase: phosphoethanolamine 6 -D-glucopyranosyl- dehydrogenase: oligogalacturonide kinase: glk thioadenosine phosphomutase: 1,N - c4771 phosphatase: nudL methyltransferase: cheR c0762 dcm rppH patA mutase 2: gpmB synthase: rluA kinase: pfkA qor idnD c0762 c5023 hmp ppnN 5'-methylthioadenosine 5-hydroxy-CTP transferase: eptA diphosphoundecaprenol rppH fadB lyase: c0319 c0762 deoB ethenoadenine 32 D-glucosamine 2'-deoxyuridine nucleosidase: mtn diphosphohydrolase: nudG O-acetyltransferase: wcaF a 5'-phospho- 3-methoxy-4- 5-dehydro-4-deoxy- a 5-methylcytosine a 5'-phospho- 2,3-diphospho- a pseudouridine D-sedoheptulose 5-dehydro- OPC8-trans- D-psicose a cellodextrin adenine 5-hydroxy-CTP 5-hydroxy-CMP repair: alkB 2-maleylacetate α hydroxypyruvate S-methylglutathione [+ 2 isozymes] phenylacetaldehyde 4-aminobutanal a semiquinone isobutanal nitrate an mRNA fragment S-methyl-5- D-ribose 5- 2/3-O-Ac- -L-Fuc- [mRNA] hydroxyphenylglycolaldehyde 3-oxo- D-glucuronate in DNA [mRNA] D-glycerate in tRNA 1,7-bisphosphate D-gluconate 6-phosphate 2-enoyl-CoA (1->3)-α-D-Glc-PP-Und SanA thio-D-ribose phosphate lipid A-core- a 1,2-diacyl- myristoyl-CoA pyrophosphoethanolamine sn-glycerol a 1-lysophosphatidylethanolamine a fatty acid glyoxal an adenine in DNA succinate

β a double [(S)-1- 3-(3,4-dihydroxyphenyl) a [release factor]- uridine 955/2504/ D-ribulose uridine 746 (3R)-3,4- a uridine 35 5-fluorouridine 5'- uridine 2457 dCTP UDP-N-acetyl- - YqjA glycerol (KDO) -lipid A a 1-palmitoyl-2-acyl-sn- uroporphyrinogen-III 54 L-idonate xylan glycerol 2- α-maltose a phosphatidylethanolamine 2 11-deoxycorticosterone 4-nitrobenzaldehyde 2-phosphoglycolate a uracil in tRNA 4-tyrosol monophosphate O-phosphoethanolamine pyridoxine acryloyl-CoA L-pneumosamine glycero-3-phosphocholine stranded DNA aminoethyl]phosphonate pyruvate L-glutamine 2580 in 23S rRNA 5-phosphate in 23S rRNA dihydroxybutanal in tRNA phosphate in 23S rRNA dCTP uroporphyrinogen-III C- 5 23S rRNA 5 Tyr 5-fluorouridine L-idonate 5- xylan α- (S)-1- protein-(glutamine-N 4-nitrobenzaldehyde Probable tRNA(m U54) 23S rRNA D-3,4- Putative alcohol tRNA pyridoxine 4- glycerol-2- acrylyl-CoA deaminase: methyltransferase: cysG 11-deoxycorticosterone hydroxyphenyllactate 955/ phosphoglycolate 746 35 5'-nucleotidase: aminoethylphosphonate ) methyltransferase: reductase: dkgB pseudouridine phosphoribulokinase: methyltransferase: pseudouridine dihydroxybutanal dehydrogenase: pseudouridine dehydrogenase: dehydrogenase: xylosidase: phosphatase: reductase: DNA reductase: kduD dehydrogenase: hcxB phosphatase: gph yjjG dcd phosphatidylglycerol N-acetyltransferase: phnO Putative uroporphyrin-III C- prmC 2504/2580 prkB trmA synthase: rluA reductase: yqhD c0762 synthase: rluF idnD pdxI yicI yhdH exonuclease: [+ 4 isozymes] suhB dUTP UDP-N-acetyl- synthase: clsB methyltransferase: hemX 5 synthase: rluC 54 746 35 2457 [(1S)-1- 4-pregnen- (R)-3-(3,4- a [release factor]-N 4-nitrobenzyl 955/ D-ribulose-1,5- a 5-methyluracil a pseudouridine (4-hydroxyphenyl) a pseudouridine 5-dehydro- α-D-xylopyranose a pseudouridine α,α-trehalose recE a pseudouridine glycolate 1,3,4-butanetriol 5-fluorouridine ethanolamine pyridoxal glycerol propionyl-CoA β-L-fucosamine YegN precorrin-2 -methyl-L-glutamine bisphosphate in tRNA in 23S rRNA D-gluconate acetamidoethyl]phosphonate 20,21-diol-3-one dihydroxyphenyl)lactate alcohol 2504/2580 in 23S rRNA acetaldehyde in tRNA in 23S rRNA hepta-acylated Kdo ethanolamine a phosphatidylglycerol a 1-lysophosphatidylcholine 2 a single lipid A (E. coli) a 5'-phosphomononucleotide stranded DNA Electron transport UDP-N-acetyl-β- UDP-α-D- UDP-α-D-galactose α-L-Fuc-(1->4)-2/3-O-Ac-α-L- [(R)-1- a single dCMP CDP a cytosine 1407 dTTP a double D-gluconate an aliphatic thymine UMP uridine complex phosphatidylglycerophosphate an N 7 -methylguanine in DNA 3,4-dihydroxyphenylglycol cholate a β-D-galactoside L-arabinitol maltose L-rhamnonate ppGpp 8-oxo-GDP glycerol 1- α-D-glucose (R)-NADPHX Fuc-(1->3)-α-D-Glc-PP-Und 6-phosphate α ω L-rhamnosamine glucuronate protein rnfA (1-octadecenoyl(9Z), 2-palmitoyl) aminoethyl]phosphonate stranded DNA 5'-deoxynucleotidase: yfdR 2'-deoxycytidine in 16S rRNA dTTP stranded DNA , -diamine thymine 5'-nucleotidase: phosphate 16S rRNA m 5 C1407 7-α-hydroxysteroid galactoside O- aldehyde diamine N- maltose O- ppGpp 8-oxo-GDP uridine phosphatidylglycerophosphatase: (R)-1- single stranded dCMP Putative alcohol diphosphate:oxidized NrdH pyrophosphohydrolase: 6-phosphogluconate L-rhamnonate oxygenase: umpG glycerol-3- glucokinase: NADPHX galactosyltransferase: endonuclease acetyltransferase: reductase: yahK acetyltransferase: kinase: udk pgpC aminoethylphosphonate endodeoxyribonuclease: phosphohydrolase: yfbR dehydrogenase: glutaredoxin-like protein methyltransferase: dehydrogenase: nudI acetyltransferase: dehydratase: phosphohydrolase: rutA diphosphatase: [+ 2 isozymes] phosphatase: glk epimerase: wcaC DNA-N 7 -methyguanine I: endA phosphatase: yieH maa N-acetyltransferase: phnO recC recB recD c0762 rsmF hdhA lacA [+ 3 isozymes] speG rhmD nudG mutT hxpA nnr [+ 2 isozymes] 2'-deoxycytidine oxidoreductase: nrdF nrdE [+ 2 isozymes] a 6-acetyl-β- (Z)-2- uridine UMP UDP-N-acetyl-β- UDP-α-D- Probable glycosylase: ycaQ [(1R)-1- a 5-methylcytosine 1407 3α,12α-dihydroxy-7- an aliphatic N- 2-dehydro-3-deoxy- α-D-glucose 1-18:1-2-16:0- a 5'-phosphooligonucleotide 3,4-dihydroxyphenylglycolaldehyde dCDP dTMP a 5'-phosphooligonucleotide D-gluconate L-arabinopyranose acetylmaltose pGp methylureidoacrylate 8-oxo-GMP glycerol (S)-NADPHX L-quinovosamine galacturonate formate formate formate β D-galactoside L-rhamnonate 6-phosphate α-D-Gal-(1->3)-α-L-Fuc-(1->4)-2/3-O UDP phosphatidylglycerol acetamidoethyl]phosphonate in 16S rRNA oxo-5 -cholan-24-oate acetyl-diamine transporter 1 -Ac-α-L-Fuc-(1->3)-α-D-Glc-PP-Und a DNA containing an N 7 -methylguanine apurinic/apyrimidinic site

SecA an N 6 -L- 5,6- UDP-β-L- dTDP-α-D- a 5-carboxymethylaminomethyluridine 34 a 5-(methoxycarbonylmethoxy) a 5,10- dUMP UDP a cytosine 1962 CTP CMP uracil dTDP-4-dehydro- cytidine 37 cis-dienelactone benzene-1,4-diol 3-mercaptopyruvate coproporphyrinogen III 3'-cmp 5,6-dihydrouracil L-quinate glycerol xylitol pyrazinamide α-lactose 3'-UMP nigerose Leu 34 threonylcarbamoyladenine dihydrothymine 6-deoxy-α-D- arabinopyranose fucopyranose in tRNA uridine in tRNA methenyltetrahydrofolate 5'-deoxynucleotidase: yfdR 2'-deoxyuridine 5'- in 23S rRNA nucleoside triphosphate 5'-nucleotidase: uracil in tRNA 5 cytidine 3'-phosphate dihydropyrimidine aldehyde aldehyde glucopyranose cytidine tRNA (5- tRNA (5- Putative 5,10- dUMP hydroquinone:hydrogen diphosphate:oxidized NrdH 23S rRNA m C1962 3-mercaptopyruvate pyrophosphohydrolase: dihydropyrimidine quinate β-galactosidase: 3'-nucleotidase: umpG oxygenase: nigerose tRNA porphyrinogen phosphohydrolase: dehydrogenase: reductase: yahK reductase: yahK pyrazinamidase: kinase: udk carboxymethylaminomethyluridine) methoxycarbonylmethoxyuridine) carboxymethylenebutenolidase: methenyltetrahydrofolate phosphohydrolase: yfbR peroxide glutaredoxin-like protein methyltransferase: sulfurtransferase: mazG dehydrogenase: dehydrogenase: umpG [+ 2 isozymes] rutA hydrolase: threonylcarbamoyladenosine peroxidase: yfeX umpG preT preA pncA lacZ YcjV -ribose methyltransferase: trmL -ribose methyltransferase: trmL c4771 hydrolase: glyA oxidoreductase: ccp rlmI sseA preT preA ydiB [+ 3 isozymes] [+ 3 isozymes] ygjK dehydratase: tcdA 2'-deoxyuridine oxidoreductase: nrdF nrdE CMP cytidine CMP α dTDP-D-β- a 5-carboxymethylaminomethyl- a 5-(methoxycarbonylmethoxy) a cyclic N 6 -L- a (6S)-5- a 5-methylcytosine 1962 cytidine uracil thymine pyrazine-2- uridine 3-ureidoacrylate dTDP-4-dehydro-6- UDP- -D-xylose 2-maleylacetate 1,4-benzoquinone dUDP pyruvate coproporphyrin III 3-dehydroquinate L-glyceraldehyde D-xylopyranose allolactose D-glucopyranose fucofuranose 2'-O-methyluridine 34 in tRNA Leu -2'-O-methyluridine 34 in tRNA threonylcarbamoyladenosine formyltetrahydrofolate in 23S rRNA carboxylate deoxy-α-D-gulose undecaprenyldiphospho- 4-amino-4- 37 in tRNA N-acetyl-(N- deoxy-α-L- molybdate α ferric α-maltose 6'-phosphate L,L-homocystine acetylglucosaminyl) a ferric N-acetyl- -D- arabinopyranosyl ferric thiosulfate a nucleoside YddW phosphate 2'-deoxycytidine enterobactin D-glucose D-cystine hydroxamate galactosamine ditrans,octacis D-methionine an aliphatic nalidixate ferrichrome sn-glycerol enterobactin M-antigen ferrichrome selenite a quaternary muramoyl-L-alanyl- D-fructose hydrophilic hydrophilic deoxycholate putrescine L-ascorbate 2,3-dioxo- agmatine arg hypoxanthine hypoxanthine thymidine a lyso-cardiolipin γ-butyrobetaine ferric ferric complex nitrate nitrate acetate D-glucose magnesium hydrogenphosphate lanthionine γ complex α-D-galactofuranose 1-phosphate -undecaprenyl sulfonate L-arabinose carbonylcyanide m-chlorophenylhydrazone molybdate putrescine adenine adenine 3-phosphate sn-glycerol xanthosine a glycerophosphodiester cobinamide complex monomer ferric coprogen selenate a C4-dicarboxylate ammonium -D-glutamyl-meso- a peptide L-lyxopyranose a D- 1-phosphate D-glucuronate cefoperazone solute < solute or tetraphenylphosphonium L-ornithine deoxycholate asn 6-phosphate L-gulonate asp arg L-canavanine guanine guanine thymine ser ser 2'-deoxyuridine xanthine a lysophosphatidylglycerol enterobactin enterobactin E. coli O16 D-ribopyranose methyl-β-D-galactoside glycolate α-maltose 6'-phosphate calcium hydrogenphosphate [+ 3 more] phosphonate β-D-galactofuranose allantoin 3-phenylpropanoate cadaverine L-arabinose 5-aminopentanoate propanoate H O putrescine putrescine D-glycerate D-glycerate xanthine xanthine N-acetylneuraminate N-acetylneuraminate N-acetylneuraminate 4-aminobutanoate L-carnitine nitrite nitrite nitrite nitrite a tripeptide a tripeptide a tripeptide a nucleoside a nucleoside orotate cytosine 2,6-diaminopimeloyl- antibiotic deoxycholate phosphate non-specific non-specific non-specific norfloxacin 2-nitroimidazole deoxycholate a drug 2 arg uracil uracil 3-phosphate [+ 6 more] urate antigen monomer- undecaprenyl D-glucose enterobactin compound L-rhamnose glucoronoside D-galacturonate fosmidomycin 900 Da chloramphenicol ion < 600 Da L-arabinose a drug xanthine a 1-lysophosphatidylethanolamine complex complex D-galactopyranose a lipopolysaccharide tellurite arsenate D-alanyl-D-alanine fosfomycin ion/solute ion/solute ion/solute a drug a drug carbonylcyanide m-chlorophenylhydrazone diphosphoundecaprenol diphosphate PTS system, Nucleoside- Ferric iron(III) predicted L-methionine/ aliphatic iron(III) ferric iron(III) PTS system, maltose and sulfate/ specific fructose- undecaprenyl- ABC arabinose multidrug tripartite L-ascorbate molybdate 2,3-diketo-L- putrescine L-arginine sn-glycerol 3-phosphate sn-glycerol 3-phosphate vitamin enterobactin Conserved cystine ABC hydroxamate galactofuranose transporter D-methionine sulfonate hydroxamate enterobactin hydroxamate ribose ABC glucose- glucose- thiosulfate channel- DctA CodB YciC YgjT MgrB Uup YjiG hypothetical TrkA YqeG FxsA EntS FtsY DnaK PPIII MurJ SbmA PhnC RhaT UidB specific PTS ExuT Fsr MdtG phosphate-α-L- exporter OmpG MdtL YbbW HcaT MscK MscS MscL CadB OmpN YdeA ABC AraE MdtK NimT Bcr GabP PotE efflux pump efflux pump AnsP PutP specific PTS ABC EmrD gulonate:Na + GltP AqpZ ABC PlaP PotE AdiC ArgO ABC RutG AdeQ AdeP UraA GudP GarP / glycerophosphodiester GhxQ GhxP RutG XanP XanQ GlpT NanC NanT NanT SdaC SstT NupC XapB UacT LplT / glycerophosphodiester GabP CaiT B ABC FepE FepE transport RfbX WzxC MglBAC NarK NarK NirC NarU MsbA DtpB DtpA DtpC ActP DgcQ PqiA YgdR YieI YghB FtsN YbdG PspC YgfX ElaB YnaJ YtfL MalX PitB Tsx NupG transporter ABC ABC transporter complex of ABC ABC ABC 12 ABC ABC transporter specific IIBC specific ABC forming enzyme II Ara4N flippase YbhFSR transporter EmrAB-TolC EmrKY-TolC enzyme II transporter symporter transporter transporter ABC transporter ABC transporter transporter ATP-binding protein transporter CPD-3604 transporter transporter transporter transporter transporter component IIABC transporter protein tsx protein fepC β a C4-dicarboxylate cytosine a quaternary a peptide L-lyxopyranose a D- D-glucuronate α hydrophilic hydrophilic L-canavanine uracil uracil thymine 2'-deoxycytidine xanthine a lyso-cardiolipin ferric ferric methyl- -D-galactoside acetate maltose component magnesium hydrogenphosphate precursor L,L-homocystine phosphonate -D-galactofuranose allantoin 3-phenylpropanoate cadaverine L-arabinose 5-aminopentanoate propanoate H O putrescine putrescine D-glycerate D-glycerate xanthine xanthine N-acetylneuraminate N-acetylneuraminate N-acetylneuraminate 4-aminobutanoate E. coli O16 M-antigen nitrite nitrite a tripeptide a tripeptide a tripeptide a nucleoside a nucleoside orotate ammonium undecaprenyldiphospho- antibiotic L-rhamnose glucoronoside D-galacturonate deoxycholate solute < non-specific non-specific non-specific solute or deoxycholate 2-nitroimidazole asn a drug asp 2 arg hypoxanthine hypoxanthine xanthine sn-glycerol ser ser thymidine urate a lysophosphatidylglycerol enterobactin enterobactin D-ribopyranose D-galactopyranose glycolate D-glucose calcium hydrogenphosphate enterobactin D-cystine a ferric D-fructose fosmidomycin β-D-galactofuranose N-acetyl-α-D- chloramphenicol L-arabinose L-arabinose a drug 2,3-dioxo- adenine adenine sn-glycerol xanthosine L-carnitine ferric nitrite nitrite a lipopolysaccharide molybdate compound N-acetyl-(N- fosfomycin 4-amino-4- 900 Da an aliphatic ion/solute ion/solute ion/solute ion < 600 Da tetraphenylphosphonium a drug L-ornithine nalidixate L-ascorbate molybdate carbonylcyanide m-chlorophenylhydrazone putrescine arg arg guanine guanine 2'-deoxyuridine a 1-lysophosphatidylethanolamine a glycerophosphodiester cobinamide complex complex antigen monomer- monomer ferrichrome tellurite D-glucose arsenate ferrichrome L-gulonate 3-phosphate 3-phosphate ferric lanthionine hydroxamate galactosamine α D-methionine cefoperazone sulfonate norfloxacin putrescine carbonylcyanide m-chlorophenylhydrazone deoxycholate agmatine γ-butyrobetaine enterobactin diphosphoundecaprenol undecaprenyl ferric coprogen nitrate nitrate maltose thiosulfate acetylglucosaminyl) deoxy- -L- [+ 6 more] enterobactin a nucleoside [+ 3 more] complex complex diphosphate D-glucose selenite muramoyl-L-alanyl- arabinopyranosyl a drug deoxycholate phosphate complex γ-D-glutamyl-meso- ditrans,octacis selenate 2,6-diaminopimeloyl- -undecaprenyl D-alanyl-D-alanine phosphate Copyright © 2014, SRI International. All rights reserved. This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.