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Calcium Acetate Capsules Type of Posting Revision Bulletin Posting Date 27–Dec–2019 Official Date 01–Jan–2020 Expert Committee Chemical Medicines Monographs 6 Reason for Revision Compliance In accordance with the Rules and Procedures of the 2015–2020 Council of Experts, the Chemical Medicines Monographs 6 Expert Committee has revised the Calcium Acetate Capsules monograph. The purpose for the revision is to add Dissolution Test 4 to accommodate FDA-approved drug products with different dissolution conditions and/or tolerances than the existing dissolution tests. • Dissolution Test 4 was validated using a YMC-Pack ODS-A C18 brand of L1 column. The typical retention time for calcium acetate is about 4.3 min. The Calcium Acetate Capsules Revision Bulletin supersedes the currently official monograph. Should you have any questions, please contact Michael Chang, Senior Scientific Liaison (301-230-3217 or [email protected]). C236679-M11403-CHM62015, rev. 00 20191227 Revision Bulletin Calcium 1 Official January 1, 2020 Calcium Acetate Capsules PERFORMANCE TESTS DEFINITION Change to read: Calcium Acetate Capsules contain NLT 90.0% and NMT · DISSOLUTION á711ñ 110.0% of the labeled amount of calcium acetate Test 1 (C4H6CaO4). Medium: Water; 900 mL IDENTIFICATION Apparatus 2: 50 rpm, with sinkers · A. The retention time of the calcium peak of the Sample Time: 10 min solution corresponds to that of the Standard solution, as Mobile phase, Standard solution, Chromatographic obtained in the Assay. system, and System suitability: Proceed as directed in · B. IDENTIFICATION TESTSÐGENERAL á191ñ, Chemical the Assay. Identification Tests, Acetate Sample solution: Pass a portion of the solution under test Sample solution: 67 mg/mL of calcium acetate from through a suitable filter of 0.45-µm pore size. Dilute with Capsule contents Medium to a concentration similar to the Standard Acceptance criteria: Meet the requirements for test B solution, if necessary. Analysis ASSAY Samples: Standard solution and Sample solution · PROCEDURE Calculate the percentage of the labeled amount of Solution A: 0.75 mM dipicolinic acid and 1.7 mM nitric acid calcium acetate (C4H6CaO4) dissolved at time point (i): in water. [NOTE—Warm water may be required to dissolve dipicolinic acid.] Resulti = (rU/rS) × CS × V × D × (1/L) × 100 Mobile phase: Acetone and Solution A (100:900). Pass through a suitable filter of 0.2-µm pore size. rU = peak response of calcium from the Sample solution Standard solution: 0.08 mg/mL of USP Calcium Acetate RS rS = peak response of calcium from the Standard in water solution Sample stock solution: Nominally 6.7 mg/mL of calcium CS = concentration of USP Calcium Acetate RS in the acetate prepared as follows. Transfer an appropriate Standard solution (mg/mL) portion of the contents of NLT 20 Capsules to a suitable V = volume of Medium, 900 mL volumetric flask. Add water to about 40% of the final D = dilution factor for the Sample solution, if needed volume of the flask and sonicate for 20 min with L = label claim (mg/Capsule) intermittent shaking. Dilute with water to volume. Pass through a suitable filter of 0.45-µm pore size. Tolerances: NLT 80% (Q) of the labeled amount of Sample solution: Nominally 0.08 mg/mL of calcium acetate calcium acetate (C4H6CaO4) is dissolved. in water from the Sample stock solution Test 2: If the product complies with this test, the labeling Chromatographic system indicates that it meets USP Dissolution Test 2. (See Chromatography á621ñ, System Suitability.) Medium: 0.1 N hydrochloric acid; 900 mL Mode: Ion chromatography Apparatus 1: 100 rpm Detector: Conductivity Time: 15 min Column: 4.0-mm × 15-cm; 5-µm packing L76 Blank: 0.2% (v/v) nitric acid Column temperature: 35° Standard solutions: 4.0, 5.0, 6.0, 7.0, and 8.0 µg/mL of Flow rate: 0.9 mL/min calcium [from commercially available, National Institute Injection volume: 10 µL of Standards and Technology (NIST) traceable standard Run time: NLT 1.5 times the retention time of the calcium solution for calcium] in Blank peak Sample solution: Pass a portion of the solution under test System suitability through a suitable filter of 1.0-µm pore size. Dilute with Sample: Standard solution Blank to a concentration similar to 6.0-µg/mL Standard Suitability requirements solution, if necessary. Column efficiency: NLT 1000 theoretical plates Instrumental conditions Relative standard deviation: NMT 2.0% (See Atomic Absorption Spectroscopy á852ñ.) Analysis Mode: Atomic absorption spectrometry Samples: Standard solution and Sample solution Analytical wavelength: 422.8 nm Calculate the percentage of the labeled amount of calcium Lamp: Calcium hollow-cathode acetate (C4H6CaO4) in the portion of Capsules taken: Flame: Air–acetylene oxidizing flame System suitability Result = (rU/rS) × (CS/CU) × 100 Samples: Blank and Standard solutions Suitability requirements rU = peak response of calcium from the Sample solution Linearity: Use the Blank to set the instrument to zero. rS = peak response of calcium from the Standard Concomitantly determine the responses for each of the solution Standard solutions. Construct a linear calibration curve CS = concentration of USP Calcium Acetate RS in the by plotting the absorbance values of the Standard Standard solution (mg/mL) solutions versus their corresponding concentrations, in CU = nominal concentration of calcium acetate in the micrograms per milliliter. Sample solution (mg/mL) Correlation coefficient: NLT 0.995 Drift: Within ±2%, 7.0-µg/mL Standard solution. See Acceptance criteria: 90.0%–110.0% Atomic Absorption Spectroscopy á852ñ, Procedure, Analysis. Analysis Sample: Sample solution © 2019 The United States Pharmacopeial Convention All Rights Reserved. C236679-M11403-CHM62015, rev. 00 20191227 2 Calcium Revision Bulletin Official January 1, 2020 From the linear calibration curve, determine the Analysis concentration (C), in µg/mL, for calcium in the Sample Sample: Sample solution solution. From the quadratic calibration curve obtained from the Calculate the percentage of the labeled amount of Correlation coefficient, determine the concentration (C), calcium acetate (C4H6CaO4) dissolved: in µg/mL, for calcium acetate in the Sample solution. Calculate the percentage of the labeled amount of Result = C × V × F × D × (Mr1/Mr2) × (1/L) × 100 calcium acetate (C4H6CaO4) dissolved: C = concentration of calcium in the Sample solution Result = C × V × F × D × (1/L) × 100 determined (µg/mL) V = volume of Medium, 900 mL C = concentration of calcium acetate in the Sample F = equivalency factor, 0.001 mg/µg solution determined (µg/mL) D = dilution factor for the Sample solution, if needed V = volume of Medium, 900 mL Mr1 = molecular weight of calcium acetate, 158.17 F = equivalency factor, 0.001 mg/µg Mr2 = molecular weight of calcium, 40.08 D = dilution factor for the Sample solution, if needed L = label claim (mg/Capsule) L = label claim (mg/Capsule) Tolerances: NLT 85% (Q) of the labeled amount of Analytical procedure 2 Titrimetric system calcium acetate (C4H6CaO4) is dissolved. Test 3: If the product complies with this test, the labeling (See Titrimetry á541ñ.) indicates that it meets USP Dissolution Test 3. Mode: Complexometric titration Tier 1 Titrant: 0.005 M edetic acid (EDTA) Medium 1: Water; 900 mL Endpoint detection: Photometric at 610 nm Apparatus 2: 100 rpm, with sinkers Analysis: To an aliquot of the Sample stock solution Time: 15 min equivalent to about 7.4 mg of calcium acetate, add 60 Tier 2 mL of 0.1 N sodium hydroxide and 0.2 g of Medium 2: Simulated gastric fluid TS; 900 mL hydroxynaphthol blue indicator. Titrate with Titrant, Apparatus 2: 100 rpm, with sinkers determining the endpoint photometrically using a Time: 15 min suitable autotitrator. Determine the amount of calcium acetate dissolved using Calculate the percentage of the labeled amount of Analytical procedure 1 or Analytical procedure 2 for Tier 1 calcium acetate (C4H6CaO4) dissolved: and Analytical procedure 3 for Tier 2. Sample stock solution: Pass a portion of the solution Result = VS × M × F × (VM/VA) × (1/L) × 100 under test through a suitable filter of 0.45-µm pore size. Dissolution procedure: Perform the test using the VS = volume of Titrant consumed by the aliquot of conditions under Tier 1. In the presence of cross-linking, Sample stock solution (mL) repeat the test with a new set of Capsules using the M = actual Titrant concentration, in molarity conditions under Tier 2. (mmol/mL) Analytical procedure 1 F = equivalency factor of calcium acetate, 158.17 Blank: 0.02 N nitric acid mg/mmol V = volume of Medium, 900 mL Standard solutions: 2.4, 3.2, 4.0, 4.8, and 5.6 µg/mL of M USP Calcium Acetate RS in Blank VA = volume of the aliquot taken for Analysis (mL) Sample solution: Nominally 3.7 µg/mL of calcium L = label claim (mg/Capsule) acetate from Sample stock solution, dilute with Blank if necessary Analytical procedure 3 Instrumental conditions Blank: Medium (See Atomic Absorption Spectroscopy á852ñ.) Titrimetric system Mode: Atomic absorption spectrometry (See Titrimetry á541ñ.) Analytical wavelength: 422.8 nm Mode: Complexometric titration Lamp: Calcium hollow-cathode Titrant: 0.005 M edetic acid (EDTA) Flame: Nitrous oxide–acetylene Endpoint detection: Visual Replicates: 4 Analysis: To an aliquot of the Sample stock solution System suitability equivalent to about 7.4 mg of calcium acetate, add 50 Samples: Blank, Standard solutions, and Sample solution mL of water, 10 mL of 0.1 N sodium hydroxide, and 0.2 Suitability requirements g of hydroxynaphthol blue indicator. Titrate with Titrant Relative standard deviation: NMT 3.0% in 4 to a blue endpoint while stirring using a magnetic replicate measurements, Standard solutions and stirring bar. Perform a Blank determination in the same Sample solution manner. Correlation coefficient: NLT 0.995, use the Blank to Calculate the percentage of the labeled amount of set the instrument to zero. Concomitantly determine calcium acetate (C4H6CaO4) dissolved: the responses for each of the Standard solutions.
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  • An Experimental and Numerical Model for the Release of Acetone from Decomposing EVA Containing Aluminium, Magnesium Or Calcium Hydroxide Fire Retardants

    An Experimental and Numerical Model for the Release of Acetone from Decomposing EVA Containing Aluminium, Magnesium Or Calcium Hydroxide Fire Retardants

    Article An experimental and numerical model for the release of acetone from decomposing EVA containing aluminium, magnesium or calcium hydroxide fire retardants Hewitt, Fiona, Rhebat, Diana Eid, Witkowski, Artur and Hull, T Richard Available at http://clok.uclan.ac.uk/16622/ Hewitt, Fiona, Rhebat, Diana Eid, Witkowski, Artur ORCID: 0000-0002-0005- 7520 and Hull, T Richard ORCID: 0000-0002-7970-4208 (2016) An experimental and numerical model for the release of acetone from decomposing EVA containing aluminium, magnesium or calcium hydroxide fire retardants. Polymer Degradation and Stability, 127 . pp. 65-78. ISSN 0141- 3910 It is advisable to refer to the publisher’s version if you intend to cite from the work. http://dx.doi.org/10.1016/j.polymdegradstab.2016.01.007 For more information about UCLan’s research in this area go to http://www.uclan.ac.uk/researchgroups/ and search for <name of research Group>. For information about Research generally at UCLan please go to http://www.uclan.ac.uk/research/ All outputs in CLoK are protected by Intellectual Property Rights law, including Copyright law. Copyright, IPR and Moral Rights for the works on this site are retained by the individual authors and/or other copyright owners. Terms and conditions for use of this material are defined in the policies page. CLoK Central Lancashire online Knowledge www.clok.uclan.ac.uk Fiona Hewitt, Diana Eid Rhebat, Artur Witkowski, T. Richard Hull, An experimental and numerical model for the release of acetone from decomposing EVA containing aluminium, magnesium or calcium hydroxide fire retardants, Polymer Degradation and Stability, Volume 127, 2016, Pages 65-78 An experimental and numerical model for the release of acetone from decomposing EVA containing aluminium, magnesium or calcium hydroxide fire retardants Authors: Fiona Hewitta, Diana Eid Rhebatb, Artur Witkowskia and T.