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Estonian Statistics on Medicines 2013 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day A ALIMENTARY TRACT AND METABOLISM 146,8152 A01 STOMATOLOGICAL PREPARATIONS 0,0760 A01A STOMATOLOGICAL PREPARATIONS 0,0760 A01AB Antiinfectives and antiseptics for local oral treatment 0,0760 A01AB09 Miconazole(O) 7139,2 g 0,2 g 0,0760 A01AB12 Hexetidine(O) 1541120 ml A01AB81 Neomycin+Benzocaine(C) 23900 pieces A01AC Corticosteroids for local oral treatment A01AC81 Dexamethasone+Thymol(dental) 2639 ml A01AD Other agents for local oral treatment A01AD80 Lidocaine+Cetylpyridinium chloride(gingival) 179340 g A01AD81 Lidocaine+Cetrimide(O) 23565 g A01AD82 Choline salicylate(O) 824240 pieces A01AD83 Lidocaine+Chamomille extract(O) 317140 g A01AD86 Lidocaine+Eugenol(gingival) 1128 g A02 DRUGS FOR ACID RELATED DISORDERS 35,6598 A02A ANTACIDS 0,9596 Combinations and complexes of aluminium, calcium and A02AD 0,9596 magnesium compounds A02AD81 Aluminium hydroxide+Magnesium hydroxide(O) 591680 pieces 10 pieces 0,1261 A02AD81 Aluminium hydroxide+Magnesium hydroxide(O) 1998558 ml 50 ml 0,0852 A02AD82 Aluminium aminoacetate+Magnesium oxide(O) 463540 pieces 10 pieces 0,0988 A02AD83 Calcium carbonate+Magnesium carbonate(O) 3049560 pieces 10 pieces 0,6497 A02AF Antacids with antiflatulents Aluminium hydroxide+Magnesium A02AF80 1000790 ml hydroxide+Simeticone(O) DRUGS FOR PEPTIC ULCER AND GASTRO- A02B 34,7001 OESOPHAGEAL REFLUX DISEASE (GORD) A02BA H2-receptor antagonists 3,5364 A02BA02 Ranitidine(O) 494352,3 g 0,3 g 3,5106 A02BA02 Ranitidine(P) 3589,5 g 0,3 g 0,0255 A02BA03 Famotidine(O) 6 g 0,04 g 0,0003 A02BC Proton pump inhibitors 31,1637 A02BC01 Omeprazole(O) 205509,8 g 0,02 g 21,8912 A02BC02 Pantoprazole(O) 97564,46 g 0,04 g 5,1963 A02BC03 Lansoprazole(O) 21,42 g 0,03 g 0,0015 A02BC05 Esomeprazole(O) 54668,04 g 0,03 g 3,8822 A02BC05 Esomeprazole(P) 2710,8 g 0,03 g 0,1925 DRUGS FOR FUNCTIONAL GASTROINTESTINAL A03 6,0070 DISORDERS DRUGS FOR FUNCTIONAL GASTROINTESTINAL A03A 4,9530 DISORDERS A03AA Synthetic anticholinergics, esters with tertiary amino group 0,7177 A03AA04 Mebeverine(O) 101070 g 0,3 g 0,7177 A03AD Papaverine and derivatives 4,2353 A03AD01 Papaverine hydrochloride(P) 68 g 0,1 g 0,0014 A03AD01 Papaverine hydrochloride(P, V) 20 g 0,1 g 0,0004 A03AD02 Drotaverine(O) 193996,8 g 0,1 g 4,1330 A03AD02 Drotaverine(P) 4715 g 0,1 g 0,1004 A03AX Other drugs for functional gastrointestinal disorders A03AX13 Simeticone(O) 378946,8774 g A03B BELLADONNA AND DERIVATIVES, PLAIN 0,1152 A03BA Belladonna alkaloids, tertiary amines 0,0907 1/44 Estonian Statistics on Medicines 2013 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day A03BA01 Atropine(O, P) 35,73 g 0,0015 g 0,0507 A03BA01 Atropine(P) 28,1 g 0,0015 g 0,0399 Belladonna alkaloids, semisynthetic, quaternary ammonium A03BB 0,0245 compounds A03BB01 Butylscopolamine(O) 83 g 0,06 g 0,0029 A03BB01 Butylscopolamine(P) 601 g 0,06 g 0,0213 A03BB01 Butylscopolamine(R) 6,1 g 0,06 g 0,0002 A03F PROPULSIVES 0,9389 A03FA Propulsives 0,9389 A03FA01 Metoclopramide(O) 10347,5 g 0,03 g 0,7348 A03FA01 Metoclopramide(P) 2225,8 g 0,03 g 0,1581 A03FA01 Metoclopramide(R) 0,55 g 0,03 g <0,0001 A03FA02 Cisapride(O) 4,2 g 0,03 g 0,0003 A03FA03 Domperidone(O) 642,6 g 0,03 g 0,0456 A03FA80 Itopride(O) 4 g A04 ANTIEMETICS AND ANTINAUSEANTS 0,1383 A04A ANTIEMETICS AND ANTINAUSEANTS 0,1383 A04AA Serotonin (5-HT3) antagonists 0,1254 A04AA01 Ondansetron(O) 43,68 g 0,016 g 0,0058 A04AA01 Ondansetron(P) 41,32 g 0,016 g 0,0055 A04AA02 Granisetron(O) 51,85 g 0,002 g 0,0552 A04AA02 Granisetron(P) 82,89 g 0,003 g 0,0589 A04AD Other antiemetics 0,0129 A04AD12 Aprepitant(O) 300,675 g 0,095 g 0,0067 A04AD81 Fosaprepitant(P) 273 g 0,095 g 0,0061 A05 BILE AND LIVER THERAPY 2,6052 A05A BILE THERAPY 0,4309 A05AA Bile acid preparations 0,4309 A05AA02 Ursodeoxycholic acid(O) 151700 g 0,75 g 0,4309 A05B LIVER THERAPY, LIPOTROPICS 2,1743 A05BA Liver therapy 2,1743 A05BA03 Silymarin(O) 3942080 pieces A05BA80 Essentsiaalsed fosfolipiidid(O) 3061770 pieces 3 pieces 2,1743 A05BA80 Essentsiaalsed fosfolipiidid(P) 3525 pieces A06 DRUGS FOR CONSTIPATION 13,9626 A06A DRUGS FOR CONSTIPATION 13,9626 A06AB Contact laxatives 7,0555 A06AB02 Bisacodyl(O) 16366,4 g 0,01 g 3,4867 A06AB02 Bisacodyl(R) 1018,3 g 0,01 g 0,2169 A06AB06 Senna glycosides(O) 17140 pieces 1 pieces 0,0365 A06AB08 Sodium picosulfate(O) 7780,8981 g 0,005 g 3,3153 A06AD Osmotically acting laxatives 6,2629 A06AD11 Lactulose(O) 19208421,6 g 6,7 g 6,1078 A06AD15 Macrogol(O) 728200 g 10 g 0,1551 Macrogol+Sodium citrate+Citric acid+Sodium A06AD80 600 ml chloride+Potassium chloride(O) Sodium sulphate, anhydrous+Potassium chloride+Sodium A06AD81 60836 pieces chloride+Macrogol+Sodium hydrogen carbonate(O) Macrogol+Potassium chloride+Sodium hydrogen A06AD84 18408 pieces carbonate+Sodium chloride(O) Sodium sulphate, anhydrous+magnesium sulfate A06AD85 13376 ml heptahydrate+Potassium sulphate(O) A06AG Enemas 0,6442 A06AG11 Laurilsulfate, incl. combinations+Sorbitol+Sodium citrate(R) 302380 pieces 1 pieces 0,6442 2/44 Estonian Statistics on Medicines 2013 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day A06AX Other drugs for constipation A06AX01 Glycerol(R) 300 pieces ANTIDIARRHEALS, INTESTINAL A07 3,5777 ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS A07A INTESTINAL ANTIINFECTIVES <0,0001 A07AA Antibiotics <0,0001 A07AA02 Nystatin(O) 10000000 U 1500000 U <0,0001 A07B INTESTINAL ADSORBENTS 0,5031 A07BC Other intestinal adsorbents 0,5031 A07BC05 Diosmectidum(O) 2125560 g 9 g 0,5031 A07C ELECTROLYTES WITH CARBOHYDRATES A07CA Oral rehydration salt formulations Sodium chloride+Potassium chloride+Sodium A07CA80 38800 pieces citrate+Glucose(O) A07D ANTIPROPULSIVES 0,8627 A07DA Antipropulsives 0,8627 A07DA03 Loperamide(O) 4049,428 g 0,01 g 0,8627 A07E INTESTINAL ANTIINFLAMMATORY AGENTS 1,7814 A07EA Corticosteroids acting locally 0,0005 A07EA06 Budesonide(O) 2,1 g 0,009 g 0,0005 A07EA06 Budesonide(R) 1,939 g A07EB Antiallergic agents, excl.corticosteroids 0,0001 A07EB01 Cromoglicic acid(O) 40 g 0,8 g 0,0001 A07EC Aminosalicylic acid and similar agents 1,7808 A07EC01 Sulfasalazine(O) 870350 g 2 g 0,9271 A07EC02 Mesalazine(O) 554970 g 1,5 g 0,7882 A07EC02 Mesalazine(R) 46133 g 1,5 g 0,0655 A07F ANTIDIARRHEAL MICROORGANISMS 0,4304 A07FA Antidiarrheal microorganisms 0,4304 A07FA02 Saccharomyces boulardii(O) 202017,5 g 1 g 0,4304 A07X OTHER ANTIDIARRHEALS A07XA Other antidiarrheals A07XA04 Racecadotril(O) 994,76 g ANTIOBESITY PREPARATIONS, EXCL. DIET A08 0,0291 PRODUCTS ANTIOBESITY PREPARATIONS, EXCL. DIET A08A 0,0291 PRODUCTS A08AB Peripherally acting antiobesity products 0,0291 A08AB01 Orlistat(O) 4924,08 g 0,36 g 0,0291 A09 DIGESTIVES, INCL. ENZYMES 1,3290 A09A DIGESTIVES, INCL. ENZYMES 1,3290 A09AA Enzyme preparations 1,3288 A09AA02 Lipase+Amylase+Protease(O) 2494810 pieces 4 pieces 1,3288 A09AC Enzyme and acid preparations, combinations 0,0003 A09AC80 Pepsin+Betaine(O) 400 pieces 3 pieces 0,0003 A10 DRUGS USED IN DIABETES 56,1556 A10A INSULINS AND ANALOGUES 15,7880 A10AB Insulins and analogues for injection, fast-acting 5,9144 A10AB01 Insulin (human)(P) 1209000 U 40 U 0,0644 A10AB04 Insulin lispro(P) 23851500 U 40 U 1,2703 A10AB05 Insulin aspart(P) 74193000 U 40 U 3,9516 A10AB06 Insulin glulisine(P) 11793000 U 40 U 0,6281 A10AC Insulins and analogues for injection, intermediate-acting 0,2075 A10AC01 Insulin (human)(P) 3895500 U 40 U 0,2075 3/44 Estonian Statistics on Medicines 2013 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day Insulins and analogues for injection, intermediate-acting A10AD 2,0160 combined with fast-acting A10AD04 Insulin lispro(P) 13137000 U 40 U 0,6997 A10AD05 Insulin aspart(P) 24715500 U 40 U 1,3164 A10AE Insulins and analogues for injection, long-acting 7,6500 A10AE04 Insulin glargine(P) 75166500 U 40 U 4,0034 A10AE05 Insulin detemir(P) 68467500 U 40 U 3,6466 BLOOD GLUCOSE LOWERING DRUGS, EXCL. A10B 40,3676 INSULINS A10BA Biguanides 18,8116 A10BA02 Metformin(O) 17659980 g 2 g 18,8116 A10BB Sulfonamides, urea derivatives 17,3304 A10BB07 Glipizide(O) 2116,8 g 0,01 g 0,4510 A10BB09 Gliclazide(O) 270787,8 g 0,06 g 9,6149 A10BB12 Glimepiride(O) 6819,81 g 0,002 g 7,2645 A10BD Combinations of oral blood glucose lowering drugs 1,3893 A10BD07 Metformin+Sitagliptin(O) 1218728 pieces 2 pieces 1,2982 A10BD10 Metformin+Saxagliptin(O) 21060 pieces 2 pieces 0,0224 A10BD11 Metformin+Linagliptin(O) 64440 pieces 2 pieces 0,0686 A10BG Thiazolidinediones 0,1815 A10BG03 Pioglitazone(O) 2555,7 g 0,03 g 0,1815 A10BH Dipeptyl peptidase 4 (DPP-4) inhibitors 2,1917 A10BH01 Sitagliptin(O) 83330,1 g 0,1 g 1,7753 A10BH03 Saxagliptin(O) 59,85 g 5 mg 0,0255 A10BH05 Linagliptin(O) 917,55 g 5 mg 0,3910 A10BX Other blood glucose lowering drugs, excl. insulins 0,4631 A10BX04 Exenatide(P) 0,1449 g 0,286 mg 0,0011 A10BX07 Liraglutide(P) 260,244 g 1,2 mg 0,4620 A11 VITAMINS 14,1663 A11A MULTIVITAMINS, COMBINATIONS 1,4736 A11AA Multivitamins with minerals 1,4736 A11AA03 Multivitamins+Mineral elements(O) 691710 pieces 1 pieces 1,4736 A11B MULTIVITAMINS, PLAIN 0,0114 A11BA Multivitamins, plain 0,0114 A11BA80 Multivitamins(O) 53700 ml 10 ml 0,0114 VITAMIN A AND D, INCL.
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    EUROPEAN JOURNAL OF SCIENTIFIC EXPLORATION VOL 3 №2 2020 Determination of Oligomer Content in Benzonatate Drug Substance by HPLC Lakshmi Narasimha Rao Katakam 1 Santhosh Kumar Ettaboina 2 Thirupathi Dongala 2 1Saptalis Pharmaceuticals LLC, New York, USA 2Aurex Pharmaceuticals Inc, East Windsor, USA Abstract. A reverse-phase liquid chromatographic method has developed and validated to determine oligomer content in Benzonatate Drug substances. This method has a separation of relatively few monomer units, which constitutes an oligomer with a minimum adequate chromatographic resolution of 1.0 from each of the subject component peaks. The separation achieved using Phenomenex Luna C18 (250 X 4.6 mm) 5 µm column at a flow rate of 1.0 ml/min with an isocratic elution method. The mobile phase consisting of 0.25% Ammonium formate buffer and methanol in the ratio 350:650 (v/v), respectively. The Oligomer compounds detection carried out at UV 310 nm, and the LC method validated as per the current ICH Q2 guidelines. The method is effectively validated and proved to be precise, specific, linear, robust, and rugged to quantitate oligomer content in Benzonatate drug substance. Key words: benzonatate (BNZ), oligomers, HPLC, method validation. Introduction Benzonatate (BNZ) is an oral antitussive drug used to relieve and suppress cough in patients older than ten years of age (Oligomer Wikipedia, 2020). Currently, BNZ is the only non-narcotic antitussive available as a prescription drug. The chemical structure resembles that of the anesthetic agents in the para-amino-benzoic acid class (such as procaine and tetracaine), BNZ exhibits anesthetic or numbing action. BNZ also inhibits the transmission of impulses of the cough reflex in the medulla's vagal nuclei (Tessalon, 2020).
  • (12) Patent Application Publication (10) Pub. No.: US 2017/0209462 A1 Bilotti Et Al

    (12) Patent Application Publication (10) Pub. No.: US 2017/0209462 A1 Bilotti Et Al

    US 20170209462A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2017/0209462 A1 Bilotti et al. (43) Pub. Date: Jul. 27, 2017 (54) BTK INHIBITOR COMBINATIONS FOR Publication Classification TREATING MULTIPLE MYELOMA (51) Int. Cl. (71) Applicant: Pharmacyclics LLC, Sunnyvale, CA A 6LX 3/573 (2006.01) A69/20 (2006.01) (US) A6IR 9/00 (2006.01) (72) Inventors: Elizabeth Bilotti, Sunnyvale, CA (US); A69/48 (2006.01) Thorsten Graef, Los Altos Hills, CA A 6LX 3/59 (2006.01) (US) A63L/454 (2006.01) (52) U.S. Cl. CPC .......... A61 K3I/573 (2013.01); A61K 3 1/519 (21) Appl. No.: 15/252,385 (2013.01); A61 K3I/454 (2013.01); A61 K 9/0053 (2013.01); A61K 9/48 (2013.01); A61 K (22) Filed: Aug. 31, 2016 9/20 (2013.01) (57) ABSTRACT Disclosed herein are pharmaceutical combinations, dosing Related U.S. Application Data regimen, and methods of administering a combination of a (60) Provisional application No. 62/212.518, filed on Aug. BTK inhibitor (e.g., ibrutinib), an immunomodulatory agent, 31, 2015. and a steroid for the treatment of a hematologic malignancy. US 2017/0209462 A1 Jul. 27, 2017 BTK INHIBITOR COMBINATIONS FOR Subject in need thereof comprising administering pomalido TREATING MULTIPLE MYELOMA mide, ibrutinib, and dexamethasone, wherein pomalido mide, ibrutinib, and dexamethasone are administered con CROSS-REFERENCE TO RELATED currently, simulataneously, and/or co-administered. APPLICATION 0008. In some aspects, provided herein is a method of treating a hematologic malignancy in a subject in need 0001. This application claims the benefit of U.S.
  • Tonsillopharyngitis - Acute (1 of 10)

    Tonsillopharyngitis - Acute (1 of 10)

    Tonsillopharyngitis - Acute (1 of 10) 1 Patient presents w/ sore throat 2 EVALUATION Yes EXPERT Are there signs of REFERRAL complication? No 3 4 EVALUATION Is Group A Beta-hemolytic Yes DIAGNOSIS Streptococcus (GABHS) • Rapid antigen detection test infection suspected? (RADT) • roat culture No TREATMENT EVALUATION No A Supportive management Is GABHS confi rmed? B Pharmacological therapy (Non-GABHS) Yes 5 TREATMENT A EVALUATE RESPONSEMIMS Supportive management TO THERAPY C Pharmacological therapy • Antibiotics Poor/No Good D Surgery, if recurrent or complicated response response REASSESS PATIENT COMPLETE THERAPY & REVIEW THE DIAGNOSIS© Not all products are available or approved for above use in all countries. Specifi c prescribing information may be found in the latest MIMS. B269 © MIMS Pediatrics 2020 Tonsillopharyngitis - Acute (2 of 10) 1 ACUTE TONSILLOPHARYNGITIS • Infl ammation of the tonsils & pharynx • Etiologies include bacterial (group A β-hemolytic streptococcus, Haemophilus infl uenzae, Fusobacterium sp, etc) & viral (infl uenza, adenovirus, coronavirus, rhinovirus, etc) pathogens • Sore throat is the most common presenting symptom in older children TONSILLOPHARYNGITIS 2 EVALUATION FOR COMPLICATIONS • Patients w/ sore throat may have deep neck infections including epiglottitis, peritonsillar or retropharyngeal abscess • Examine for signs of upper airway obstruction Signs & Symptoms of Sore roat w/ Complications • Trismus • Inability to swallow liquids • Increased salivation or drooling • Peritonsillar edema • Deviation of uvula